Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:153907309C>T	ENST00000361217.4	-	18	3118	c.2700G>A	c.(2698-2700)caG>caA	p.Q900Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.							p.Q788Q(1)|p.Q900Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.642000													4	59					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46543102	46543102	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr13:46543102C>T	ENST00000242848.4	-	14	3925	c.3577G>A	c.(3577-3579)Ggg>Agg	p.G1193R	ZC3H13_ENST00000282007.3_Missense_Mutation_p.G1193R|ZC3H13_ENST00000378921.2_Missense_Mutation_p.G149R			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1193	Ser-rich.						nucleic acid binding|zinc ion binding	p.G1193W(1)		cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CGATTGCTCCCGAGGCTGCTG	0.507000													7	184					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57947418	57947418	+	Missense_Mutation	SNP	T	T	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr14:57947418T>A	ENST00000216445.3	-	5	686	c.550A>T	c.(550-552)Agt>Tgt	p.S184C	C14orf105_ENST00000422976.2_Missense_Mutation_p.S183C|C14orf105_ENST00000534126.1_Missense_Mutation_p.S183C	NM_001283057.1|NM_018168.2	NP_001269986.1|NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	184										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						TCCCTTGGACTTTGCTTATTA	0.403000													10	74					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213981	3213981	+	RNA	SNP	A	A	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr17:3213981A>C	ENST00000573491.1	-	0	359																											TATGACCGCTATCTGGCCATC	0.562000													31	66					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185988674	185988674	+	Splice_Site	SNP	T	T	G			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:185988674T>G	ENST00000271588.4	+	35	5701	c.5472T>G	c.(5470-5472)gtT>gtG	p.V1824V	HMCN1_ENST00000367492.2_Splice_Site_p.V1824V	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1824					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TAAATATAGTTCCTCCAACAA	0.403000													10	58					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57947420	57947420	+	Missense_Mutation	SNP	T	T	G			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr14:57947420T>G	ENST00000216445.3	-	5	684	c.548A>C	c.(547-549)cAa>cCa	p.Q183P	C14orf105_ENST00000422976.2_Missense_Mutation_p.Q182P|C14orf105_ENST00000534126.1_Missense_Mutation_p.Q182P	NM_001283057.1|NM_018168.2	NP_001269986.1|NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	183										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						CCTTGGACTTTGCTTATTAAT	0.393000													10	73					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57259302	57259302	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr11:57259302G>A	ENST00000278426.3	-	9	1260	c.905C>T	c.(904-906)cCc>cTc	p.P302L	SLC43A1_ENST00000533515.1_5'UTR|SLC43A1_ENST00000528450.1_Missense_Mutation_p.P302L	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	302					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CAGGAAAGTGGGGGAGCAGAG	0.602000											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	47					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50484310	50484310	+	Silent	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr22:50484310G>A	ENST00000266182.6	-	5	482	c.483C>T	c.(481-483)acC>acT	p.T161T	TTLL8_ENST00000440475.1_Silent_p.T161T					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GCTCACTCTCGGTGCAGAGGC	0.617000													4	9					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17488042	17488042	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr19:17488042C>T	ENST00000252590.4	-	1	117	c.56G>A	c.(55-57)cGg>cAg	p.R19Q		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	19						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCAGCAGCCCCGAGAGCTGCC	0.622000													44	76					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66641820	66641820	+	Missense_Mutation	SNP	T	T	G			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr12:66641820T>G	ENST00000261233.4	+	12	2081	c.1660T>G	c.(1660-1662)Tta>Gta	p.L554V	IRAK3_ENST00000457197.2_Missense_Mutation_p.L493V	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	554					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		ATCCCAGGACTTAAGGCCCTA	0.458000													57	81					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56699384	56699384	+	Silent	SNP	A	A	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr8:56699384A>T	ENST00000260129.5	+	4	1404	c.927A>T	c.(925-927)acA>acT	p.T309T		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	309					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GCTCTGGTACAAGTGATAAGG	0.343000													15	35					0	0	1	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32521666	32521666	+	RNA	SNP	T	T	C	rs117454723	by1000genomes	TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr6:32521666T>C	ENST00000411500.1	-	0	817					NR_001298.1																						AACAGCCCTGTCCCAAGGAAG	0.507000													3	20					0	0	1	0	0
POP1	10940	broad.mit.edu	37	8	99142398	99142398	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr8:99142398A>G	ENST00000401707.2	+	5	760	c.679A>G	c.(679-681)Aca>Gca	p.T227A	POP1_ENST00000349693.3_Missense_Mutation_p.T227A	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	227					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GGAGAGGCCAACAGTCAAGAG	0.498000													5	70					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162769603	162769603	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:162769603G>A	ENST00000367917.3	+	5	586	c.518G>A	c.(517-519)aGt>aAt	p.S173N	HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000254521.3_Missense_Mutation_p.S173N			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	173					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity	p.S173N(4)		endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TCATCTCGCAGTGCAAGGAAA	0.458000													3	46					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160741690	160741690	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr2:160741690G>T	ENST00000263636.4	-	6	1055	c.1028C>A	c.(1027-1029)cCa>cAa	p.P343Q	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.P343Q|LY75_ENST00000554112.1_Missense_Mutation_p.P343Q|LY75_ENST00000553424.1_Missense_Mutation_p.P343Q|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.P343Q	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		ATTATTTAATGGTTTCCTGCA	0.398000													34	52					6.90743e-12	7.87125e-12	1	1	0
DOCK11	139818	broad.mit.edu	37	X	117744241	117744241	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chrX:117744241C>T	ENST00000276204.6	+	28	3030	c.2956C>T	c.(2956-2958)Cga>Tga	p.R986*	DOCK11_ENST00000276202.7_Nonsense_Mutation_p.R986*			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	986					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TCAGCTTCCCCGAGGCCAGAG	0.383000													35	49					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37306396	37306396	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr2:37306396G>A	ENST00000233099.5	-	3	300	c.205C>T	c.(205-207)Cga>Tga	p.R69*	HEATR5B_ENST00000354531.2_Nonsense_Mutation_p.R69*	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	69							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				AATAATTTTCGTGTAGGTGGT	0.313000													13	27					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46652877	46652877	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr22:46652877C>A	ENST00000253255.5	-	1	6342	c.6343G>T	c.(6343-6345)Gaa>Taa	p.E2115*		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2115					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TAGTTCCATTCATGCTGACCA	0.443000													3	33					1	1	1	1	0
BGN	633	broad.mit.edu	37	X	152773797	152773797	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chrX:152773797G>A	ENST00000331595.4	+	8	1187	c.1001G>A	c.(1000-1002)gGc>gAc	p.G334D	BGN_ENST00000480756.1_3'UTR	NM_001711.4	NP_001702.1	P21810	PGS1_HUMAN	biglycan	334						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TACTACAACGGCATCAGCCTC	0.577000													4	173					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102600	22102600	+	Missense_Mutation	SNP	C	C	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr14:22102600C>A	ENST00000542433.1	-	1	496	c.399G>T	c.(397-399)caG>caT	p.Q133H		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGTGCAGGGGCTGACATATTG	0.552000													16	7					2.23348e-06	2.43202e-06	1	1	0
PHKA2	5256	broad.mit.edu	37	X	18936876	18936876	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chrX:18936876C>T	ENST00000379942.4	-	19	2725	c.2060G>A	c.(2059-2061)cGc>cAc	p.R687H		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	687					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					GAAGACATGGCGGTCTTCTGT	0.448000													43	76					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189045	50189045	+	Silent	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr12:50189045G>A	ENST00000335999.6	-	8	2799	c.2598C>T	c.(2596-2598)ggC>ggT	p.G866G		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	862	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						GGTCAGTGGGGCCAGGTACTA	0.637000													4	93					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								19	24					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10672385	10672385	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr19:10672385G>A	ENST00000312962.6	-	6	483	c.464C>T	c.(463-465)tCg>tTg	p.S155L	KRI1_ENST00000361821.5_Missense_Mutation_p.S151L|KRI1_ENST00000537964.1_5'UTR	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	155	Glu-rich.									NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			ACTTTGCGACGATGTCTCCTG	0.607000													6	140					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30938455	30938455	+	Silent	SNP	T	T	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr11:30938455T>C	ENST00000597505.1	-	24	3413	c.3414A>G	c.(3412-3414)aaA>aaG	p.K1138K	DCDC1_ENST00000339794.5_Silent_p.K217K|DCDC1_ENST00000406071.2_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction			p.K217K(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					CAAAGAGCCCTTTTTCCGTTT	0.413000													3	53					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185988673	185988673	+	Splice_Site	SNP	T	T	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:185988673T>A	ENST00000271588.4	+	35	5700	c.5471T>A	c.(5470-5472)gTt>gAt	p.V1824D	HMCN1_ENST00000367492.2_Splice_Site_p.V1824D	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1824					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTAAATATAGTTCCTCCAACA	0.403000													10	58					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101627180	101627180	+	Silent	SNP	T	T	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr5:101627180T>C	ENST00000310954.6	-	2	772	c.486A>G	c.(484-486)gtA>gtG	p.V162V		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	162					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CAAAGAATGATACAAATAAAG	0.398000													5	27					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46793156	46793156	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr6:46793156T>C	ENST00000230588.4	+	8	713	c.704T>C	c.(703-705)tTt>tCt	p.F235S		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	235	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATCCCTGAGTTTAACTCCATT	0.428000													18	39					0	0	1	0	0
CXorf38	159013	broad.mit.edu	37	X	40495933	40495933	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chrX:40495933G>A	ENST00000378426.1	-	4	893	c.296C>T	c.(295-297)cCc>cTc	p.P99L	CXorf38_ENST00000440784.2_Missense_Mutation_p.P133L|CXorf38_ENST00000327877.5_Missense_Mutation_p.P218L|CXorf38_ENST00000378421.1_Missense_Mutation_p.P99L			Q8TB03	CX038_HUMAN	chromosome X open reading frame 38	218										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	12						ATCTTCCTCGGGGATGTGAAC	0.423000													9	13					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27303351	27303351	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr8:27303351G>T	ENST00000397501.1	+	29	3063	c.2255G>T	c.(2254-2256)aGc>aTc	p.S752I	PTK2B_ENST00000397497.4_Intron|PTK2B_ENST00000517339.1_Intron|PTK2B_ENST00000544172.1_Missense_Mutation_p.S752I|PTK2B_ENST00000346049.5_Missense_Mutation_p.S752I|PTK2B_ENST00000420218.2_Intron|PTK2B_ENST00000338238.4_Intron	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	752	Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		ACGCTCACCAGCCCTATGGAG	0.542000													5	137					1.23904e-05	1.29177e-05	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185988675	185988675	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:185988675C>T	ENST00000271588.4	+	35	5702	c.5473C>T	c.(5473-5475)Cct>Tct	p.P1825S	HMCN1_ENST00000367492.2_Missense_Mutation_p.P1825S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1825					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AAATATAGTTCCTCCAACAAT	0.403000													10	58					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	98943528	98943528	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr8:98943528G>T	ENST00000254898.5	+	3	721	c.490G>T	c.(490-492)Gtc>Ttc	p.V164F	MATN2_ENST00000524308.1_Missense_Mutation_p.V164F|MATN2_ENST00000521689.1_Missense_Mutation_p.V164F|MATN2_ENST00000522025.2_Intron|MATN2_ENST00000520016.1_Missense_Mutation_p.V164F	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	164	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGTGCCACGGGTCATAATGAT	0.607000													12	23					4.36969e-10	4.86625e-10	1	1	0
KIAA1407	57577	broad.mit.edu	37	3	113724396	113724396	+	Missense_Mutation	SNP	C	C	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr3:113724396C>A	ENST00000295878.3	-	10	1973	c.1827G>T	c.(1825-1827)aaG>aaT	p.K609N	KIAA1407_ENST00000545063.1_Missense_Mutation_p.K440N	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	609										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTCTCTGGGCTTTGACAGCA	0.502000													7	82					5.18039e-06	5.51824e-06	1	1	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	60					0	0	1	0	0
TBC1D27	96597	broad.mit.edu	37	17	16829265	16829265	+	RNA	SNP	G	G	A			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr17:16829265G>A	ENST00000261651.2	-	0	3115																											GATTTCTTTGGGGACAGCAGG	0.582000													3	6					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95556791	95556791	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr10:95556791T>C	ENST00000371418.4	+	8	1165	c.905T>C	c.(904-906)cTg>cCg	p.L302P	LGI1_ENST00000371413.3_Intron|LGI1_ENST00000542308.1_Missense_Mutation_p.L254P	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	302					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				GTGGCCCAGCTGTTTGGTGGC	0.393000													41	73					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148009497	148009497	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:148009497C>T	ENST00000369219.1	-	16	1826	c.1810G>A	c.(1810-1812)Gat>Aat	p.D604N				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	604	NBPF 7.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					TCTTTCTCATCCAACAGCTCC	0.478000													20	164					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24199150	24199150	+	Silent	SNP	G	G	A	rs145453785	byFrequency	TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr8:24199150G>A	ENST00000265769.4	+	16	1820	c.1710G>A	c.(1708-1710)tcG>tcA	p.S570S	RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000397649.3_Silent_p.S317S|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	570	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding	p.S570S(1)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AAGGTGGGTCGGATAATTTGC	0.413000													7	108					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27088645	27088646	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:27088645_27088646delTA	ENST00000324856.7	+	7	2625_2626	c.2254_2255delTA	c.(2254-2256)tatfs	p.Y752fs	ARID1A_ENST00000457599.2_Frame_Shift_Del_p.Y752fs|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.Y369fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	752					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACAAATAGGTTATATGCAGAGG	0.480			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	66	---	---	---	---					
GNAI3	2773	broad.mit.edu	37	1	110121875	110121876	+	Frame_Shift_Ins	INS	-	-	G			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr1:110121875_110121876insG	ENST00000369851.4	+	4	463_464	c.353_354insG	c.(352-357)gtcatgfs	p.M119fs		NM_006496.3	NP_006487.1	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	119					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		GAAGAAGGAGTCATGACTCCAG	0.446													7	55	---	---	---	---					
ARIH2	10425	broad.mit.edu	37	3	49004696	49004701	+	In_Frame_Del	DEL	GGCGTG	GGCGTG	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr3:49004696_49004701delGGCGTG	ENST00000356401.4	+	6	865_870	c.526_531delGGCGTG	c.(526-531)ggcgtgdel	p.GV180del	ARIH2_ENST00000490095.1_3'UTR|ARIH2_ENST00000449376.1_In_Frame_Del_p.GV180del	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	180					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		CGTCAAGGACGGCGTGGGCGTGGGTG	0.476													7	60	---	---	---	---					
SERPINB9	5272	broad.mit.edu	37	6	2900835	2900836	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr6:2900835_2900836delAG	ENST00000380698.4	-	2	99_100	c.10_11delCT	c.(10-12)cttfs	p.L4fs		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	4					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TGCATTAGAAAGAGTTTCCATG	0.436													16	161	---	---	---	---					
KANK1	23189	broad.mit.edu	37	9	712394	712397	+	Frame_Shift_Del	DEL	AAAC	AAAC	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr9:712394_712397delAAAC	ENST00000382303.1	+	7	2280_2283	c.1628_1631delAAAC	c.(1627-1632)gaaacafs	p.ET543fs	KANK1_ENST00000382293.3_Frame_Shift_Del_p.ET385fs|KANK1_ENST00000382297.2_Frame_Shift_Del_p.ET543fs|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	543					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		ACCTCCGTGGAAACAAACAGTGTA	0.515													7	90	---	---	---	---					
CBX5	23468	broad.mit.edu	37	12	54651393	54651393	+	Frame_Shift_Del	DEL	T	T	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr12:54651393delT	ENST00000209875.4	-	2	178	c.42delA	c.(40-42)tcafs	p.S14fs	CBX5_ENST00000550411.1_Frame_Shift_Del_p.S14fs|CBX5_ENST00000439541.2_Frame_Shift_Del_p.S14fs	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5	14	Poly-Ser.				blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						CCTCATCCTCTGAAGAAGAAC	0.502													40	81	---	---	---	---					
NAA16	79612	broad.mit.edu	37	13	41943360	41943362	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr13:41943360_41943362delGAA	ENST00000379406.3	+	15	2212_2214	c.1888_1890delGAA	c.(1888-1890)gaadel	p.E634del	NAA16_ENST00000497143.1_3'UTR	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	634					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding	p.E630D(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						aaaaagagatgaagaagaagaag	0.345													17	49	---	---	---	---					
MAP3K14	9020	broad.mit.edu	37	17	43344891	43344893	+	RNA	DEL	CTC	CTC	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr17:43344891_43344893delCTC	ENST00000344686.2	-	0	2311_2313				MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000586450.1_RNA|MAP3K14-AS1_ENST00000585351.1_RNA|MAP3K14-AS1_ENST00000585780.1_RNA|MAP3K14-AS1_ENST00000588504.1_RNA			Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						ACATCCCAGACTCCTCCTTGCTC	0.611													7	10	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42795197	42795198	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chr19:42795197_42795198delTG	ENST00000572681.2	+	11	5072_5073	c.5004_5005delTG	c.(5002-5007)actgtcfs	p.V1669fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.V760fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.V760fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	760					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CGCCTGCCACTGTCACTAACCT	0.668			"""Mis, F, S"""		oligodendroglioma								17	17	---	---	---	---					
ARMCX2	9823	broad.mit.edu	37	X	100910841	100910844	+	Frame_Shift_Del	DEL	ATAG	ATAG	-			TCGA-P5-A77W-01A-11D-A32B-08	TCGA-P5-A77W-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0d366d4-b18f-44b3-9e4e-fc49e38c5601	5e92215f-5cb4-459d-91fa-0b0026d14be5	g.chrX:100910841_100910844delATAG	ENST00000328766.5	-	5	2184_2187	c.1731_1734delCTAT	c.(1729-1734)atctatfs	p.IY577fs	ARMCX2_ENST00000330154.2_Frame_Shift_Del_p.IY577fs|ARMCX2_ENST00000356824.4_Frame_Shift_Del_p.IY577fs	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	577						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						TGAGATTGTCATAGATAATCTCAA	0.348													9	108	---	---	---	---					
