Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RTCB	51493	broad.mit.edu	37	22	32804799	32804799	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr22:32804799T>C	ENST00000216038.5	-	2	213	c.115A>G	c.(115-117)Aat>Gat	p.N39D	RTCB_ENST00000451746.2_Missense_Mutation_p.N39D	NM_014306.4	NP_055121.1			RNA 2',3'-cyclic phosphate and 5'-OH ligase																		AGAGCATCATTCACATAGAAA	0.438000													3	60					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196973838	196973838	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr1:196973838A>G	ENST00000367414.5	+	9	1506	c.1450A>G	c.(1450-1452)Acc>Gcc	p.T484A	CFHR5_ENST00000256785.4_Missense_Mutation_p.T460A	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	460	Sushi 8.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						CAATGGAGATACCACCTCATT	0.408000													35	63					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118909856	118909856	+	Missense_Mutation	SNP	A	A	G	rs147312682		TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr3:118909856A>G	ENST00000264234.3	+	5	522	c.373A>G	c.(373-375)Atg>Gtg	p.M125V	UPK1B_ENST00000497685.1_Missense_Mutation_p.M45V|UPK1B_ENST00000460625.1_Missense_Mutation_p.M117V	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	125					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		CCTGAAGCAGATGCTAGAGAG	0.453000													13	405					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65838061	65838061	+	Missense_Mutation	SNP	A	A	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr11:65838061A>C	ENST00000320580.4	+	1	137	c.104A>C	c.(103-105)cAg>cCg	p.Q35P		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	35	Gly-rich.|Poly-Gln.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						ccgccgccgcagcagcagcag	0.796000													2	3					0	0	1	0	0
ODF2L	57489	broad.mit.edu	37	1	86826179	86826179	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr1:86826179T>C	ENST00000359242.3	-	12	1465	c.1184A>G	c.(1183-1185)gAa>gGa	p.E395G	ODF2L_ENST00000317336.7_Missense_Mutation_p.E395G|ODF2L_ENST00000370566.3_Missense_Mutation_p.E366G|ODF2L_ENST00000394731.1_Missense_Mutation_p.E235G|ODF2L_ENST00000524695.1_5'UTR|ODF2L_ENST00000294678.2_Missense_Mutation_p.E366G|ODF2L_ENST00000370567.1_Missense_Mutation_p.E366G	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like	395						centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		GAGTTCATTTTCAACAGATAC	0.303000													13	16					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108719067	108719067	+	Silent	SNP	C	C	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chrX:108719067C>A	ENST00000218006.2	-	2	390	c.99G>T	c.(97-99)ctG>ctT	p.L33L		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	33					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						ACAAGCACCACAGGAACTTGG	0.567000											OREG0019905	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	54					1.62957e-23	1.702e-23	1	1	0
ZNF518B	85460	broad.mit.edu	37	4	10445618	10445618	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:10445618T>C	ENST00000326756.3	-	3	2773	c.2335A>G	c.(2335-2337)Agg>Ggg	p.R779G		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TTAAGAACCCTCAACACAGCC	0.473000													20	45					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414470	29414470	+	Missense_Mutation	SNP	A	A	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chrX:29414470A>C	ENST00000378993.1	+	4	1131	c.458A>C	c.(457-459)aAa>aCa	p.K153T	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.K153T	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	153	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TATTTTGAAAAAGCTGAACTT	0.393000													6	97					0	0	1	0	0
CTBP1	1487	broad.mit.edu	37	4	1206203	1206203	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:1206203G>A	ENST00000382952.3	-	10	1499	c.1115C>T	c.(1114-1116)cCg>cTg	p.P372L	CTBP1_ENST00000290921.6_Missense_Mutation_p.P383L	NM_001012614.1	NP_001012632.1	Q13363	CTBP1_HUMAN	C-terminal binding protein 1	383					interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		CACCACGCCCGGAGGGTACCT	0.721000													4	2					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406859	75406859	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr10:75406859G>A	ENST00000394810.2	-	4	2700	c.2551C>T	c.(2551-2553)Cgg>Tgg	p.R851W	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.R627W	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	851	Pro-rich.					cytoplasm|cytoskeleton	actin binding	p.R627W(2)|p.R851W(1)		breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GGCTGATGCCGCATAAAATCT	0.577000													4	122					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43619143	43619143	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr10:43619143G>A	ENST00000355710.3	+	17	3058	c.2826G>A	c.(2824-2826)tgG>tgA	p.W942*	RET_ENST00000340058.5_Nonsense_Mutation_p.W942*	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	942	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCCTGCTGTGGGAGATCGTGA	0.602000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				4	170					0	0	1	0	0
RBFOX2	23543	broad.mit.edu	37	22	36177682	36177682	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr22:36177682G>A	ENST00000405409.2	-	3	732	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C	RBFOX2_ENST00000397303.2_Missense_Mutation_p.R102C|RBFOX2_ENST00000416721.2_Missense_Mutation_p.R121C|RBFOX2_ENST00000359369.4_Missense_Mutation_p.R101C|RBFOX2_ENST00000414461.2_Missense_Mutation_p.R121C|RBFOX2_ENST00000262829.7_Missense_Mutation_p.R121C|RBFOX2_ENST00000449924.2_Missense_Mutation_p.R121C|RBFOX2_ENST00000438146.2_Missense_Mutation_p.R192C	NM_001031695.2|NM_001082576.1|NM_001082577.1|NM_014309.2	NP_001026865.1|NP_001076045.1|NP_001076046.1|NP_055124.1	O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	131	RRM.	Interaction with RNA (By similarity).			estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						TCCCGGAAGCGGAAAGGAATA	0.448000													5	267					0	0	1	0	0
TMEM86A	144110	broad.mit.edu	37	11	18723300	18723300	+	Missense_Mutation	SNP	T	T	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr11:18723300T>G	ENST00000280734.2	+	3	563	c.467T>G	c.(466-468)tTc>tGc	p.F156C		NM_153347.1	NP_699178.1	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	156						integral to membrane				endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	11						CTTATCGGCTTCATGGGCTGG	0.627000													13	19					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41513608	41513608	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr22:41513608C>T	ENST00000263253.7	+	2	1731	c.512C>T	c.(511-513)gCg>gTg	p.A171V		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	171					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GGGATGAATGCGGGCATGAAT	0.502000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				3	50					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170476964	170476964	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:170476964C>T	ENST00000439128.2	-	17	2109	c.1469G>A	c.(1468-1470)gGg>gAg	p.G490E	NEK1_ENST00000511633.1_Intron|NEK1_ENST00000512193.1_Intron|NEK1_ENST00000507142.1_Missense_Mutation_p.G490E|NEK1_ENST00000510533.1_Intron	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	490					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		ACCTGCAGCCCCATAAGGAAA	0.413000													21	47					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								7	50					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366669	248366669	+	Silent	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr1:248366669A>G	ENST00000456743.1	+	1	338	c.300A>G	c.(298-300)caA>caG	p.Q100Q		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGCCACACAAATTTTCTTCT	0.488000													35	290					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53276924	53276924	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr16:53276924A>G	ENST00000566029.1	+	13	3259	c.3050A>G	c.(3049-3051)aAt>aGt	p.N1017S	CHD9_ENST00000398510.3_Missense_Mutation_p.N1017S|CHD9_ENST00000564845.1_Missense_Mutation_p.N1017S|CHD9_ENST00000447540.1_Missense_Mutation_p.N1017S			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1017	Helicase ATP-binding.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AAACTCATGAATCTGGTAAGT	0.279000													3	57					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8616093	8616093	+	Silent	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:8616093C>T	ENST00000429646.2	+	7	2988	c.195C>T	c.(193-195)tcC>tcT	p.S65S	CPZ_ENST00000360986.4_Silent_p.S457S|CPZ_ENST00000382480.2_Silent_p.S320S|CPZ_ENST00000315782.6_Silent_p.S446S			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	457	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CAGGCATGTCCGATTTCAACT	0.612000													33	29					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								17	37					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	155860969	155860969	+	Translation_Start_Site	SNP	T	T	C			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr3:155860969T>C	ENST00000471742.1	+	1	219	c.2T>C	c.(1-3)aTg>aCg	p.M1T	KCNAB1_ENST00000389636.5_Intron|KCNAB1_ENST00000490337.1_Intron	NM_003471.3	NP_003462.2	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTTTGAAACATGCATCTGTAT	0.458000													9	16					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53603147	53603147	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr13:53603147G>A	ENST00000219022.2	+	1	254	c.176G>A	c.(175-177)aGc>aAc	p.S59N		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	59	Ser-rich.				cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		tccagccgcagcTTAGGCAGC	0.572000													27	72					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	101					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160061405	160061405	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr5:160061405C>T	ENST00000327245.5	-	12	2183	c.1337G>A	c.(1336-1338)cGa>cAa	p.R446Q	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	446					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTGCAACGTCGGAACACCAT	0.502000													24	78					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322596	79322596	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr9:79322596C>T	ENST00000428286.1	-	8	4717	c.3517G>A	c.(3517-3519)Gac>Aac	p.D1173N	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D1532N			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1532					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTATCTCTGTCAAAATTTCCA	0.448000													4	11					0	0	1	0	0
WDR31	114987	broad.mit.edu	37	9	116080790	116080790	+	Missense_Mutation	SNP	T	T	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr9:116080790T>A	ENST00000374193.4	-	10	1154	c.908A>T	c.(907-909)gAt>gTt	p.D303V	WDR31_ENST00000374195.3_Missense_Mutation_p.D178V|WDR31_ENST00000341761.4_Missense_Mutation_p.D302V|WDR31_ENST00000461942.1_5'UTR	NM_001012361.2|NM_145241.3	NP_001012361.1|NP_660284.1	Q8NA23	WDR31_HUMAN	WD repeat domain 31	303										NS(1)|large_intestine(1)|lung(2)|prostate(2)	6						CACCTTGCAATCATGTGATGA	0.423000													16	73					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30534025	30534025	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr17:30534025G>A	ENST00000358365.3	+	17	1740	c.1513G>A	c.(1513-1515)Gaa>Aaa	p.E505K	RHOT1_ENST00000581094.1_Missense_Mutation_p.E505K|RHOT1_ENST00000394692.2_Missense_Mutation_p.E505K|RHOT1_ENST00000583994.1_Missense_Mutation_p.E378K|RHOT1_ENST00000354266.3_Missense_Mutation_p.E484K|RHOT1_ENST00000333942.6_Missense_Mutation_p.E505K|RHOT1_ENST00000545287.2_Missense_Mutation_p.E505K	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	505	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding	p.E505Q(1)		NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				CAAATCCTTTGAATACTGTGC	0.373000													37	75					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377747	50377747	+	Silent	SNP	C	C	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chrX:50377747C>A	ENST00000376020.2	-	4	1351	c.1326G>T	c.(1324-1326)ggG>ggT	p.G442G	SHROOM4_ENST00000289292.7_Silent_p.G442G|SHROOM4_ENST00000460112.3_Silent_p.G326G	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	442					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TCCACTGGTGCCCATCCTGTA	0.577000													19	35					8.34094e-07	8.34094e-07	1	1	0
ARHGEF15	22899	broad.mit.edu	37	17	8215685	8215685	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr17:8215685C>T	ENST00000361926.3	+	2	438	c.328C>T	c.(328-330)Cca>Tca	p.P110S	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.P110S	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	110	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.P110T(1)		breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CTCCGCCTCCCCAGAACCTGC	0.672000													4	158					0	0	1	0	0
PRPF19	27339	broad.mit.edu	37	11	60665317	60665317	+	Splice_Site	SNP	C	C	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr11:60665317C>G	ENST00000227524.4	-	15	1623		c.e15+1			NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19						DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						CCAGCCTCTACCTGTAAAGTG	0.527000													3	92					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16040277	16040277	+	Silent	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr19:16040277G>A	ENST00000402119.4	-	2	759	c.333C>T	c.(331-333)acC>acT	p.T111T	CYP4F11_ENST00000326742.8_Silent_p.T111T|CYP4F11_ENST00000248041.8_Silent_p.T111T	NM_021187.3	NP_067010.3	Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CTGAGGCACTGGTGATAGGCC	0.582000													61	101					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7533275	7533275	+	Silent	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:7533275G>A	ENST00000507866.2	+	3	676	c.567G>A	c.(565-567)acG>acA	p.T189T	SORCS2_ENST00000511199.1_3'UTR|SORCS2_ENST00000329016.9_Silent_p.T17T	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	189						integral to membrane	neuropeptide receptor activity	p.T39T(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						ATTTCGGGACGTCCTACACCA	0.602000													7	13					0	0	1	0	0
PSMA2	5683	broad.mit.edu	37	7	42966160	42966160	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr7:42966160A>G	ENST00000442788.1	-	3	241	c.226T>C	c.(226-228)Tac>Cac	p.Y76H	PSMA2_ENST00000445517.1_Intron|PSMA2_ENST00000223321.4_Missense_Mutation_p.Y76H|PSMA2_ENST00000538645.1_5'UTR			P25787	PSA2_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 2	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(2)	10						ATGCCACTGTACACCAAACCT	0.373000													3	45					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25475834	25475834	+	RNA	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr15:25475834G>A	ENST00000453082.2	+	0	1429					NR_003343.1																						GACTTCTGTCGGCCTCGCTTT	0.617000													3	24					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122396945	122396945	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr12:122396945G>T	ENST00000288912.4	+	13	2932	c.2078G>T	c.(2077-2079)aGa>aTa	p.R693I	WDR66_ENST00000397454.2_Missense_Mutation_p.R693I	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	693							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		AAATATTCCAGAACCAGTGTG	0.423000													8	152					1.06961e-07	1.09287e-07	1	1	0
ETNPPL	64850	broad.mit.edu	37	4	109675776	109675776	+	Splice_Site	SNP	C	C	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:109675776C>G	ENST00000296486.3	-	5	655	c.501G>C	c.(499-501)gtG>gtC	p.V167V	ETNPPL_ENST00000411864.2_Splice_Site_p.V161V|ETNPPL_ENST00000512646.1_Splice_Site_p.V109V|ETNPPL_ENST00000510706.1_Splice_Site_p.V127V	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase																		AGACACTTACCACATGTACAA	0.348000													9	26					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47545900	47545900	+	Missense_Mutation	SNP	G	G	A	rs145450812		TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr21:47545900G>A	ENST00000300527.4	+	26	2275	c.2171G>A	c.(2170-2172)cGt>cAt	p.R724H	COL6A2_ENST00000397763.1_Missense_Mutation_p.R724H|COL6A2_ENST00000310645.5_Missense_Mutation_p.R724H|COL6A2_ENST00000357838.4_Missense_Mutation_p.R724H|COL6A2_ENST00000409416.1_Missense_Mutation_p.R724H	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	724	Nonhelical region.|VWFA 2.		R -> C.		axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CAGAAGACACGTGTGTTTGCG	0.642000													15	61					0	0	1	0	0
IKBKG	8517	broad.mit.edu	37	X	153780226	153780226	+	Silent	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chrX:153780226G>A	ENST00000393549.2	+	2	132	c.9G>A	c.(7-9)agG>agA	p.R3R	IKBKG_ENST00000369609.5_Silent_p.R71R|IKBKG_ENST00000369601.3_Silent_p.R3R|IKBKG_ENST00000369606.4_Silent_p.R3R|IKBKG_ENST00000455588.2_Silent_p.R3R|IKBKG_ENST00000263518.6_Silent_p.R3R|IKBKG_ENST00000470142.1_Silent_p.R3R|IKBKG_ENST00000369602.3_Silent_p.R3R|IKBKG_ENST00000369607.1_Silent_p.R3R			Q9Y6K9	NEMO_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	3					activation of MAPK activity|induction of apoptosis|innate immune response|interspecies interaction between organisms|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	metal ion binding|protein domain specific binding|signal transducer activity			endometrium(1)|lung(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGATGAATAGGCACCTCTGGA	0.577000													12	177					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55984889	55984889	+	Silent	SNP	G	G	A	rs141577956	by1000genomes	TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr4:55984889G>A	ENST00000263923.4	-	3	535	c.240C>T	c.(238-240)agC>agT	p.S80S		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	80	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGAGGCCATCGCTGCACTCAG	0.502000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			11	49					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170027173	170027173	+	Silent	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr2:170027173G>A	ENST00000263816.3	-	59	11553	c.11268C>T	c.(11266-11268)ccC>ccT	p.P3756P		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3756	LDL-receptor class A 31.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGCACTCCCGGGGAGCTGGAA	0.552000													29	38					0	0	1	0	0
LINC00359	100887754	broad.mit.edu	37	13	97600364	97600364	+	RNA	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr13:97600364C>T	ENST00000442322.1	-	0	153																											CTTCTTTTTCCAAGTATATAC	0.403000													5	6					0	0	1	0	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													4	105					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								6	58					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32445757	32445757	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr2:32445757A>G	ENST00000282587.5	+	14	1398	c.1361A>G	c.(1360-1362)aAt>aGt	p.N454S	SLC30A6_ENST00000406369.1_Missense_Mutation_p.N380S|SLC30A6_ENST00000379343.2_Missense_Mutation_p.N494S|SLC30A6_ENST00000538303.1_Missense_Mutation_p.N425S|SLC30A6_ENST00000357055.3_Missense_Mutation_p.N257S|SLC30A6_ENST00000435660.1_Missense_Mutation_p.N431S	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	454				N -> S (in Ref. 4; AAH66903).		Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGAACTAATAATAGAATTGGA	0.353000													5	48					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78433848	78433851	+	Splice_Site	DEL	CAGT	CAGT	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr1:78433848_78433851delCAGT	ENST00000370767.1	-	3	335_338	c.248_251delACTG	c.(247-252)gactgt>gt	p.DC83fs	FUBP1_ENST00000370768.2_Splice_Site_p.DC83fs|FUBP1_ENST00000436586.2_Splice_Site_p.DC104fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	83					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding	p.?(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						GGAATACTTACAGTCATTTTGAGG	0.319			"""F, N"""		oligodendroglioma								16	16	---	---	---	---					
EXOG	9941	broad.mit.edu	37	3	38548446	38548449	+	Frame_Shift_Del	DEL	TAGT	TAGT	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr3:38548446_38548449delTAGT	ENST00000287675.5	+	5	728_731	c.632_635delTAGT	c.(631-636)atagttfs	p.IV211fs	EXOG_ENST00000422077.2_Frame_Shift_Del_p.IV161fs|EXOG_ENST00000358249.2_Frame_Shift_Del_p.IV71fs	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	211						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						GGAAAGAAAATAGTTAGTTACCAG	0.353													11	46	---	---	---	---					
C5orf42	65250	broad.mit.edu	37	5	37154027	37154030	+	Frame_Shift_Del	DEL	ATAG	ATAG	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr5:37154027_37154030delATAG	ENST00000274258.7	-	41	8304_8307	c.4717_4720delCTAT	c.(4717-4722)ctattgfs	p.LL1573fs	C5orf42_ENST00000508244.1_Frame_Shift_Del_p.LL2675fs|C5orf42_ENST00000425232.2_Frame_Shift_Del_p.LL2675fs			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2675										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CGTTTCCACAATAGATAATCTTCT	0.431													23	53	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32523362	32523363	+	RNA	INS	-	-	GATA	rs142676080	by1000genomes	TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr6:32523362_32523363insGATA	ENST00000411500.1	-	0	458					NR_001298.1																						AAAGCAATGTGGATAAAGGGAC	0.431													3	6	---	---	---	---					
ADAT2	134637	broad.mit.edu	37	6	143771733	143771735	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr6:143771733_143771735delCTC	ENST00000237283.8	-	1	75_77	c.61_63delGAG	c.(61-63)gagdel	p.E21del	ADAT2_ENST00000367593.1_5'UTR	NM_182503.2	NP_872309.2	Q7Z6V5	ADAT2_HUMAN	adenosine deaminase, tRNA-specific 2	21					tRNA processing		hydrolase activity|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)	8				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		ACTTTTCGGTCTCCTCTGCCGAC	0.665													43	177	---	---	---	---					
LATS1	9113	broad.mit.edu	37	6	150001374	150001376	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr6:150001374_150001376delGAA	ENST00000543571.1	-	5	2775_2777	c.2228_2230delTTC	c.(2227-2232)cttcga>cga	p.L743del	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_In_Frame_Del_p.L743del	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	743	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ACTTGATTTCGAAGAAGAACATC	0.384													23	112	---	---	---	---					
FAM84B	157638	broad.mit.edu	37	8	127568724	127568726	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr8:127568724_127568726delTCC	ENST00000304916.3	-	2	1364_1366	c.909_911delGGA	c.(907-912)gaggac>gac	p.E303del		NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	303						cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			TGCCTCTCCGTCCTCCTCCTCGG	0.700													2	4	---	---	---	---					
RPLP0P2	113157	broad.mit.edu	37	11	61405251	61405252	+	RNA	INS	-	-	A			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr11:61405251_61405252insA	ENST00000496593.1	+	0	1855_1856					NR_002775.2																						agaaagaaaagaaaaaaaaaat	0.366													2	4	---	---	---	---					
USP28	57646	broad.mit.edu	37	11	113704275	113704276	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr11:113704275_113704276delTT	ENST00000003302.4	-	7	693_694	c.625_626delAA	c.(625-627)aagfs	p.K209fs	USP28_ENST00000537706.1_Frame_Shift_Del_p.K209fs|USP28_ENST00000545540.1_Frame_Shift_Del_p.K84fs|USP28_ENST00000542033.1_5'UTR|USP28_ENST00000260188.5_Frame_Shift_Del_p.K209fs	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	209					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GATATTTCTCTTTTCCTGTAGA	0.332													26	39	---	---	---	---					
TAS2R31	259290	broad.mit.edu	37	12	11183257	11183258	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr12:11183257_11183258delTT	ENST00000390675.2	-	1	748_749	c.677_678delAA	c.(676-678)aaafs	p.K226fs	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	226					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						TTTGCAAAGCTTTTATGTGGAC	0.396													34	149	---	---	---	---					
HDGFRP3	50810	broad.mit.edu	37	15	83876152	83876152	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr15:83876152delC	ENST00000299633.4	-	1	618	c.15delG	c.(13-15)cggfs	p.R5fs	RP11-382A20.4_ENST00000565495.1_RNA	NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		5					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						ACTCGCGGGGCCGCGGACGCG	0.756													2	4	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546140	3546141	+	RNA	INS	-	-	AA	rs74546027		TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr16:3546140_3546141insAA	ENST00000574423.2	+	0	111																											gactccgtctcaaaaaaaaaaa	0.559													2	4	---	---	---	---					
ATAD5	79915	broad.mit.edu	37	17	29220737	29220740	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr17:29220737_29220740delAAAG	ENST00000321990.4	+	21	5244_5247	c.4866_4869delAAAG	c.(4864-4869)acaaagfs	p.TK1622fs		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1622					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ATCCAGAGACAAAGAAATCTATTC	0.392													45	73	---	---	---	---					
LRRC37A2	474170	broad.mit.edu	37	17	44630791	44630793	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr17:44630791_44630793delAAG	ENST00000576629.1	+	12	5330_5332	c.4835_4837delAAG	c.(4834-4839)caagaa>caa	p.E1613del	ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000445552.2_Intron|ARL17A_ENST00000337845.7_Intron|LRRC37A2_ENST00000333412.3_In_Frame_Del_p.E1613del|ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000570550.1_Intron			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1613						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AGGTCATTACAAGAAGATGAAGA	0.369													23	243	---	---	---	---					
CACNA1G	8913	broad.mit.edu	37	17	48653584	48653584	+	Frame_Shift_Del	DEL	A	A	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr17:48653584delA	ENST00000352832.5	+	8	2193	c.1821delA	c.(1819-1821)ctafs	p.L607fs	CACNA1G_ENST00000515165.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000354983.4_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000512389.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000502264.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000514181.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000507336.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000442258.2_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000514079.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000513689.2_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000359106.5_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000507609.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000514717.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000515765.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000513964.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000503485.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000507510.2_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000358244.5_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000416767.4_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000510366.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000360761.4_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000429973.2_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000505165.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000515411.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000510115.1_Frame_Shift_Del_p.L607fs|CACNA1G_ENST00000507896.1_Frame_Shift_Del_p.L607fs	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	607					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGAAGGCACTAGTAGAGGTGG	0.637													2	4	---	---	---	---					
MATK	4145	broad.mit.edu	37	19	3785085	3785086	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr19:3785085_3785086delCA	ENST00000310132.6	-	2	446_447	c.48_49delTG	c.(46-51)tgtgatfs	p.CD16fs	MATK_ENST00000585778.1_Frame_Shift_Del_p.CD16fs|MATK_ENST00000395045.2_Intron|MATK_ENST00000395040.2_Intron	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	16					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGCAGAATCACAGCCGTGAA	0.619													23	43	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42795543	42795544	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr19:42795543_42795544delAA	ENST00000572681.2	+	11	5418_5419	c.5350_5351delAA	c.(5350-5352)aaafs	p.K1784fs	CIC_ENST00000160740.3_Frame_Shift_Del_p.K875fs|CIC_ENST00000575354.2_Frame_Shift_Del_p.K875fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	875					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CACCAACGGCAAAGTCCTGGCT	0.683			"""Mis, F, S"""		oligodendroglioma								21	19	---	---	---	---					
BIRC7	79444	broad.mit.edu	37	20	61867458	61867458	+	Frame_Shift_Del	DEL	A	A	-			TCGA-P5-A77X-01A-11D-A32B-08	TCGA-P5-A77X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a1b13a0-7298-4022-915f-dd2acdfd704f	6fb29fc2-6fba-49f9-ba3f-4404eb6eea1b	g.chr20:61867458delA	ENST00000217169.3	+	1	224	c.10delA	c.(10-12)aaafs	p.K4fs	BIRC7_ENST00000342412.6_Frame_Shift_Del_p.K4fs	NM_139317.1	NP_647478.1	Q96CA5	BIRC7_HUMAN	baculoviral IAP repeat containing 7	4					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)	12	all_cancers(38;2.72e-09)					CATGGGACCTAAAGACAGTGC	0.627													2	4	---	---	---	---					
