Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TP53	7157	broad.mit.edu	37	17	7577115	7577115	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr17:7577115A>G	ENST00000420246.2	-	8	955	c.823T>C	c.(823-825)Tgt>Cgt	p.C275R	TP53_ENST00000455263.2_Missense_Mutation_p.C275R|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.C275R|TP53_ENST00000445888.2_Missense_Mutation_p.C275R|TP53_ENST00000269305.4_Missense_Mutation_p.C275R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	275	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.C275G(7)|p.C275R(7)|p.C275fs*31(2)|p.?(2)|p.C275fs*20(1)|p.L265_K305del41(1)|p.R273_C275delRVC(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.C275fs*70(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGACAGGCACAAACACGCACC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	2					0	0	1	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32527349	32527349	+	RNA	SNP	T	T	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr13:32527349T>C	ENST00000428783.1	+	0	1049																											GCGGGGGGCCTCCAAGCTGGT	0.632000													3	26					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202915646	202915646	+	Silent	SNP	G	G	A			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr1:202915646G>A	ENST00000340990.5	-	4	649	c.351C>T	c.(349-351)ccC>ccT	p.P117P	ADIPOR1_ENST00000436244.1_Silent_p.P117P|ADIPOR1_ENST00000367254.3_Silent_p.P117P	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	117					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGGAGGGCATGGGAGGTCTAT	0.512000													3	52					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76533486	76533486	+	Silent	SNP	C	C	T			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr17:76533486C>T	ENST00000389840.5	-	19	2878	c.2754G>A	c.(2752-2754)gtG>gtA	p.V918V	DNAH17_ENST00000585328.1_Silent_p.V915V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GATCTGAGCCCACCTCCAGGG	0.602000													6	17					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58467639	58467639	+	Silent	SNP	T	T	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr20:58467639T>C	ENST00000357552.3	-	23	2136	c.1911A>G	c.(1909-1911)ggA>ggG	p.G637G	SYCP2_ENST00000371001.2_Silent_p.G637G			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	637					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCAATGTGTCTCCTGACGAAG	0.313000													3	38					0	0	1	0	0
MOAP1	64112	broad.mit.edu	37	14	93649977	93649977	+	Missense_Mutation	SNP	C	C	G			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr14:93649977C>G	ENST00000556883.1	-	2	1095	c.611G>C	c.(610-612)aGg>aCg	p.R204T	MOAP1_ENST00000298894.4_Missense_Mutation_p.R204T			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	204	RASSF1-binding.				activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		tagcaatcgccttctcttctc	0.463000													5	65					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740801	71740801	+	Silent	SNP	G	G	A			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr18:71740801G>A	ENST00000269500.5	-	10	1535	c.1200C>T	c.(1198-1200)caC>caT	p.H400H	FBXO15_ENST00000419743.2_Silent_p.H476H|FBXO15_ENST00000580806.1_5'UTR	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	400										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		CCAGCTCCACGTGCACTCTTC	0.502000													85	90					0	0	1	0	0
ZNF581	51545	broad.mit.edu	37	19	56156055	56156055	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr19:56156055G>A	ENST00000587252.1	+	2	391	c.118G>A	c.(118-120)Gga>Aga	p.G40R	ZNF581_ENST00000270451.5_Missense_Mutation_p.G40R|ZNF581_ENST00000588537.1_Missense_Mutation_p.G40R			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	40					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CTCCTCCATCGGATCTCCCCA	0.612000													10	4					0	0	1	0	0
CTSA	5476	broad.mit.edu	37	20	44523724	44523724	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr20:44523724G>A	ENST00000372484.3	+	11	1376	c.1094G>A	c.(1093-1095)cGg>cAg	p.R365Q	CTSA_ENST00000191018.5_Missense_Mutation_p.R347Q|CTSA_ENST00000354880.5_Missense_Mutation_p.R348Q|CTSA_ENST00000372459.2_Missense_Mutation_p.R347Q	NM_000308.2|NM_001127695.1	NP_000299.2|NP_001121167.1	P10619	PPGB_HUMAN	cathepsin A	347					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CCGTACGTGCGGAAGGCCCTC	0.612000													17	22					0	0	1	0	0
ZNF710	374655	broad.mit.edu	37	15	90611149	90611149	+	Silent	SNP	T	T	G			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr15:90611149T>G	ENST00000268154.4	+	2	1031	c.780T>G	c.(778-780)ggT>ggG	p.G260G		NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			ACACGGCGGGTTCGACCGTGG	0.652000													5	45					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43223344	43223344	+	Missense_Mutation	SNP	G	G	T			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr6:43223344G>T	ENST00000259750.4	+	8	780	c.697G>T	c.(697-699)Gca>Tca	p.A233S	TTBK1_ENST00000304139.5_Missense_Mutation_p.A182S	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	233	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGTGGAGTTTGCAGTGGGCCA	0.632000													6	7					4.096e-09	4.45217e-09	1	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								17	23					0	0	1	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768408	31768408	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr21:31768408T>C	ENST00000355459.2	+	1	17	c.4T>C	c.(4-6)Tcc>Ccc	p.S2P		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	2						intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CATCAACATGTCCTACAACTG	0.522000													69	15					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18550345	18550345	+	Silent	SNP	T	T	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr18:18550345T>C	ENST00000399799.2	-	23	3724	c.2784A>G	c.(2782-2784)agA>agG	p.R928R		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1		Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TAATCTCTTGTCTATTTCTTG	0.368000													16	29					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91994297	91994297	+	Silent	SNP	T	T	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr9:91994297T>C	ENST00000450295.1	-	16	2687	c.1911A>G	c.(1909-1911)caA>caG	p.Q637Q	SEMA4D_ENST00000339861.4_Intron|SEMA4D_ENST00000343780.4_Intron|SEMA4D_ENST00000438547.2_Silent_p.Q637Q|SEMA4D_ENST00000420987.1_Intron|SEMA4D_ENST00000422704.2_Silent_p.Q637Q|SEMA4D_ENST00000455551.2_Intron|SEMA4D_ENST00000356444.2_Silent_p.Q637Q			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	637					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						TGGCGACCACTTGGAAGACCG	0.517000													6	233					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	10					0.004672	0.004672	1	1	0
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cacfs	p.H479fs	FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													2	4	---	---	---	---					
FOXQ1	94234	broad.mit.edu	37	6	1313791	1313791	+	Frame_Shift_Del	DEL	C	C	-			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr6:1313791delC	ENST00000296839.2	+	1	1117	c.852delC	c.(850-852)cgcfs	p.R285fs		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	285	Pro-rich.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TCCGCAGCCGCCGCCTCAGGG	0.776													2	4	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150816	65150816	+	RNA	DEL	A	A	-			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr7:65150816delA	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCC	0.463													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													2	4	---	---	---	---					
CHTF18	63922	broad.mit.edu	37	16	838678	838678	+	Frame_Shift_Del	DEL	G	G	-			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr16:838678delG	ENST00000317063.6	+	2	585	c.585delG	c.(583-585)gcgfs	p.A195fs	CHTF18_ENST00000455171.2_5'UTR|CHTF18_ENST00000262315.9_5'UTR			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				TCGGGCTCGCGGACGGTATGG	0.721													2	4	---	---	---	---					
PSMB6	5694	broad.mit.edu	37	17	4699584	4699584	+	Frame_Shift_Del	DEL	C	C	-			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr17:4699584delC	ENST00000270586.3	+	1	146	c.95delC	c.(94-96)tccfs	p.S32fs		NM_001270481.1|NM_002798.2	NP_001257410.1|NP_002789.1	P28072	PSB6_HUMAN	proteasome (prosome, macropain) subunit, beta type, 6	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(3)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11						CGAGAAGTTTCCACTGGGGTG	0.607													2	4	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028117	55028118	+	Frame_Shift_Ins	INS	-	-	T			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chr17:55028117_55028118insT	ENST00000240316.4	-	2	519_520	c.485_486insA	c.(484-486)aacfs	p.N162fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	162						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTTTTCTCTTGTTTTTTTTGCT	0.366													8	208	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76920179	76920180	+	Frame_Shift_Ins	INS	-	-	C			TCGA-R8-A6YH-01A-21D-A32B-08	TCGA-R8-A6YH-10B-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	869ec76d-1e6f-40c1-9bd6-9d26bfd543ad	34cd7573-262b-451f-a866-4540450147b3	g.chrX:76920179_76920180insC	ENST00000373344.5	-	11	4111_4112	c.3897_3898insG	c.(3895-3900)gggaaafs	p.K1300fs	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Frame_Shift_Ins_p.K1262fs	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1300					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	GTTCTTTTTTTCCCTTCTTCTG	0.371			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						37	7	---	---	---	---					
