Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBN2	254048	broad.mit.edu	37	7	138946218	138946218	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr7:138946218A>T	ENST00000473989.3	+	6	1126	c.1126A>T	c.(1126-1128)Agc>Tgc	p.S376C	UBN2_ENST00000288561.8_Missense_Mutation_p.S293C	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2											NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						AAATCTGAGCAGCGGTGATCC	0.478000													42	49					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30735046	30735046	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr16:30735046C>T	ENST00000262518.4	+	25	4686	c.4301C>T	c.(4300-4302)cCa>cTa	p.P1434L	SRCAP_ENST00000344771.4_Missense_Mutation_p.P1276L|SRCAP_ENST00000395059.2_Missense_Mutation_p.P1372L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1434	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GTCTCAGTTCCATTGTCATCT	0.582000													5	197					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	69					0	0	1	0	0
MIR27A	407018	broad.mit.edu	37	19	13947327	13947327	+	RNA	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr19:13947327C>T	ENST00000385073.1	-	0	4					NR_029501.1																						AGCCCTGCTCCTCAGGCCAGG	0.657000													8	11					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481346	142481346	+	RNA	SNP	T	T	C	rs137999173	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr7:142481346T>C	ENST00000603901.1	+	0	420					NR_001296.3																						CCGAGTGCCTTATCTCCGGCT	0.567000													3	21					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182359504	182359504	+	Nonsense_Mutation	SNP	C	C	G			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:182359504C>G	ENST00000397033.2	+	12	1734	c.1304C>G	c.(1303-1305)tCa>tGa	p.S435*		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	435					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CAGTCTATATCAGGACAAATT	0.308000													4	129					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													5	53					0.0477658	0.0488272	1	1	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	34					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141986794	141986794	+	Silent	SNP	A	A	G			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:141986794A>G	ENST00000389484.3	-	6	1779	c.808T>C	c.(808-810)Tta>Cta	p.L270L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	270					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCATCTGTTAATCCTCCTGCT	0.313000										TSP Lung(27;0.18)			5	81					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004293	248004293	+	Silent	SNP	T	T	C			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr1:248004293T>C	ENST00000355784.2	-	1	961	c.906A>G	c.(904-906)agA>agG	p.R302R		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCATGACCTTTCTAACAGCTT	0.373000													25	48					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36841171	36841171	+	RNA	SNP	A	A	G			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr14:36841171A>G	ENST00000557188.1	+	0	802																											CTATGCTAGTATAGACTATAC	0.323000													3	30					0	0	1	0	0
GOLGA6L3	100133220	broad.mit.edu	37	15	83014106	83014106	+	Silent	SNP	T	T	C			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr15:83014106T>C	ENST00000557886.1	-	6	576	c.477A>G	c.(475-477)gtA>gtG	p.V159V															p.V159V(12)		endometrium(6)|kidney(5)|prostate(1)	12						GTAGCTGCTCTACCTTAGATG	0.498000													4	1					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97157052	97157052	+	Silent	SNP	G	G	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr8:97157052G>A	ENST00000287020.5	-	2	1206	c.1107C>T	c.(1105-1107)gaC>gaT	p.D369D		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	369					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					TAATCCAGTCGTCCCAGCCCA	0.637000													7	17					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													4	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466815	179466815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:179466815G>A	ENST00000589042.1	-	284	55407	c.55183C>T	c.(55183-55185)Cag>Tag	p.Q18395*	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.Q16754*|TTN_ENST00000460472.2_Nonsense_Mutation_p.Q9330*|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q9522*|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.Q15827*|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.Q9455*|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16754	Fibronectin type-III 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCTAATCTGTGAGCCAGCT	0.413000													10	72					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148701035	148701035	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr7:148701035C>T	ENST00000286091.4	-	10	2021	c.1789G>A	c.(1789-1791)Gtg>Atg	p.V597M		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	597	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			AAGCCCTCCACCTTATAGCGG	0.552000													14	31					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								19	42					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													3	13					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17199374	17199374	+	Silent	SNP	A	A	G			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr21:17199374A>G	ENST00000285681.2	+	14	1914	c.1545A>G	c.(1543-1545)agA>agG	p.R515R	USP25_ENST00000400183.2_Silent_p.R515R|USP25_ENST00000285679.6_Silent_p.R515R|USP25_ENST00000351097.5_Intron	NM_001283042.1	NP_001269971.1	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	515					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TTTCATCGAGATCAGTAATAC	0.468000													31	70					0	0	1	0	0
SLC25A27	9481	broad.mit.edu	37	6	46637948	46637948	+	Silent	SNP	C	C	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr6:46637948C>A	ENST00000371347.5	+	7	1033	c.781C>A	c.(781-783)Cga>Aga	p.R261R	SLC25A27_ENST00000411689.2_Intron|SLC25A27_ENST00000452689.2_Silent_p.R175R	NM_001204051.1|NM_004277.4	NP_001190980.1|NP_004268.3	O95847	UCP4_HUMAN	solute carrier family 25, member 27	261					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane				central_nervous_system(1)|kidney(1)|lung(4)|prostate(1)|urinary_tract(1)	8			Lung(136;0.192)			GAATCAACCACGAGATAAACA	0.328000													3	30					1	1	1	1	0
PADI3	51702	broad.mit.edu	37	1	17594365	17594365	+	Missense_Mutation	SNP	C	C	T	rs146396025		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr1:17594365C>T	ENST00000375460.3	+	6	600	c.560C>T	c.(559-561)aCg>aTg	p.T187M		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	187					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GTCCTGCGGACGCAGGGCCCT	0.577000													23	37					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641152	99641152	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr14:99641152G>A	ENST00000345514.2	-	3	2074	c.1808C>T	c.(1807-1809)gCg>gTg	p.A603V	BCL11B_ENST00000357195.3_Missense_Mutation_p.A674V|BCL11B_ENST00000443726.2_Missense_Mutation_p.A480V	NM_001282238.1|NM_022898.1	NP_001269167.1|NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	674	Gly-rich.					nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGCAGCGGCGCGGGCTTGCG	0.776000			T	TLX3	T-ALL								11	8					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46629478	46629478	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr17:46629478C>A	ENST00000470495.1	-	1	1806	c.359G>T	c.(358-360)gGc>gTc	p.G120V	HOXB3_ENST00000485909.2_Intron|HOXB3_ENST00000476342.1_Missense_Mutation_p.G120V|HOXB3_ENST00000489475.1_Missense_Mutation_p.G47V|HOXB3_ENST00000311626.4_Missense_Mutation_p.G120V|HOXB3_ENST00000472863.1_Missense_Mutation_p.G47V|HOXB3_ENST00000490677.1_Intron|HOXB3_ENST00000498678.1_Missense_Mutation_p.G120V|HOXB3_ENST00000460160.1_Intron|HOXB-AS3_ENST00000465846.2_RNA			P14651	HXB3_HUMAN	homeobox B3	120					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GGAGTTGGTGCCGGGACCGCA	0.597000													151	202					3.7336e-74	3.90331e-74	1	1	0
PARD3	56288	broad.mit.edu	37	10	34558691	34558691	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr10:34558691T>C	ENST00000374789.3	-	22	3647	c.3322A>G	c.(3322-3324)Atg>Gtg	p.M1108V	PARD3_ENST00000374790.3_Missense_Mutation_p.M1048V|PARD3_ENST00000374794.3_Missense_Mutation_p.M996V|PARD3_ENST00000545693.1_Missense_Mutation_p.M1092V|PARD3_ENST00000374788.3_Missense_Mutation_p.M1105V|PARD3_ENST00000545260.1_Missense_Mutation_p.M1018V|PARD3_ENST00000350537.4_Missense_Mutation_p.M1062V|PARD3_ENST00000346874.4_Missense_Mutation_p.M1071V	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1108					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TTGAGAGCCATGGAACCTTCA	0.473000													11	32					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13114159	13114159	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr18:13114159G>A	ENST00000506447.1	+	42	7278	c.7198G>A	c.(7198-7200)Gca>Aca	p.A2400T	CEP192_ENST00000325971.8_Missense_Mutation_p.A1804T|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Missense_Mutation_p.A1925T	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1995										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCCTGAAAACGCATGCCTTTC	0.388000													4	179					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													5	52					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	T	C	rs121912666		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr17:7578190T>C	ENST00000420246.2	-	6	791	c.659A>G	c.(658-660)tAt>tGt	p.Y220C	TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.Y220C|TP53_ENST00000455263.2_Missense_Mutation_p.Y220C|TP53_ENST00000413465.2_Missense_Mutation_p.Y220C|TP53_ENST00000359597.4_Missense_Mutation_p.Y220C|TP53_ENST00000445888.2_Missense_Mutation_p.Y220C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	220	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(278)|p.Y127C(24)|p.Y220S(12)|p.?(11)|p.0?(8)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.Y127S(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*2(1)|p.V218fs*26(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	10					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103465909	103465909	+	Missense_Mutation	SNP	C	C	T	rs147856179	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr14:103465909C>T	ENST00000361246.2	-	5	877	c.589G>A	c.(589-591)Gtg>Atg	p.V197M		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	197	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TACCTGTGCACGTAATGAAGC	0.463000													44	60					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166987180	166987180	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr1:166987180A>T	ENST00000367872.4	+	10	1269	c.1025A>T	c.(1024-1026)gAt>gTt	p.D342V	MAEL_ENST00000367870.2_Missense_Mutation_p.D311V|MAEL_ENST00000491055.1_3'UTR	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	342					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GTTGTATTGGATGCAGGGCGT	0.458000													7	67					0	0	1	0	0
MOAP1	64112	broad.mit.edu	37	14	93650096	93650096	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr14:93650096C>G	ENST00000556883.1	-	2	976	c.492G>C	c.(490-492)aaG>aaC	p.K164N	MOAP1_ENST00000298894.4_Missense_Mutation_p.K164N			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	164					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		acactctcagctttttatact	0.517000													27	67					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132270106	132270106	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr5:132270106A>C	ENST00000265343.5	-	3	1030	c.651T>G	c.(649-651)gaT>gaG	p.D217E	AFF4_ENST00000491831.1_5'UTR|AFF4_ENST00000378595.3_Missense_Mutation_p.D217E	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	217	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAGTTTGCATCAGGGTCCC	0.463000													4	80					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													5	55					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24240178	24240178	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:24240178C>T	ENST00000338315.4	+	5	494	c.494C>T	c.(493-495)gCg>gTg	p.A165V	MFSD2B_ENST00000406420.3_Missense_Mutation_p.A165V			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	165					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						CCCTACACAGCGCTCACCATG	0.667000													2	2					0	0	1	0	0
COMMD9	29099	broad.mit.edu	37	11	36302379	36302379	+	Silent	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr11:36302379C>T	ENST00000263401.5	-	2	76	c.60G>A	c.(58-60)tcG>tcA	p.S20S	COMMD9_ENST00000532705.1_Silent_p.S20S|COMMD9_ENST00000452374.2_Intron	NM_014186.3	NP_054905.2	Q9P000	COMD9_HUMAN	COMM domain containing 9	20										kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	5	all_lung(20;0.211)	all_hematologic(20;0.107)				CAACATCTTTCGAGGAGGCCT	0.383000													19	20					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56743287	56743287	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr12:56743287G>C	ENST00000314128.4	-	15	1287	c.1264C>G	c.(1264-1266)Cta>Gta	p.L422V	STAT2_ENST00000418572.2_Missense_Mutation_p.L418V|STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000557235.1_Missense_Mutation_p.L418V			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	422					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						GTCACACCTAGTGGCCCCTGG	0.527000													7	159					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23383131	23383131	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr16:23383131C>T	ENST00000343070.2	+	7	1255	c.1079C>T	c.(1078-1080)cCg>cTg	p.P360L	SCNN1B_ENST00000307331.5_Missense_Mutation_p.P405L|SCNN1B_ENST00000568085.1_Intron|SCNN1B_ENST00000568923.1_Missense_Mutation_p.P333L	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	360					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CCCTACAGCCCGTGCACCGTG	0.587000													34	85					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37902419	37902419	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr17:37902419C>T	ENST00000309185.3	+	13	1578	c.1328C>T	c.(1327-1329)gCc>gTc	p.A443V	GRB7_ENST00000394209.2_Silent_p.C472C|GRB7_ENST00000445327.2_Silent_p.C495C|GRB7_ENST00000394211.3_Silent_p.C472C|GRB7_ENST00000394204.1_Missense_Mutation_p.A443V|GRB7_ENST00000309156.4_Silent_p.C472C			Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	0	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity	p.C472C(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCTCTTTGTGCCACCTGCAGA	0.587000													5	129					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89083951	89083951	+	RNA	DEL	A	A	-	rs111608027		TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr2:89083951delA	ENST00000393525.3	+	0	576																											CTTTTTTTTCAGTGTATTTCT	0.348													2	4	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028117	55028118	+	Frame_Shift_Ins	INS	-	-	T			TCGA-S9-A6TU-01A-12D-A32B-08	TCGA-S9-A6TU-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d474edd0-517b-42c3-bc4a-25ed1a5ab460	1cf5eb20-7436-43b2-99c7-321917c0c0b6	g.chr17:55028117_55028118insT	ENST00000240316.4	-	2	519_520	c.485_486insA	c.(484-486)aacfs	p.N162fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	162						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTTTTCTCTTGTTTTTTTTGCT	0.366													9	206	---	---	---	---					
