Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MSLNL	401827	broad.mit.edu	37	16	830799	830799	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr16:830799T>G	ENST00000293892.3	-	3	201	c.202A>C	c.(202-204)Acc>Ccc	p.T68P	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						TGTGCACGGGTAGGTGACAGC	0.592000													5	237					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302544	123302544	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr7:123302544C>T	ENST00000458573.2	+	2	1061	c.904C>T	c.(904-906)Cgt>Tgt	p.R302C	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	302						cytoskeleton	actin binding|tropomyosin binding										CACGGAGCTGCGTTTCCATAA	0.537000													5	147					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72316192	72316192	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr11:72316192C>T	ENST00000334456.5	-	4	558	c.313G>A	c.(313-315)Ggg>Agg	p.G105R	PDE2A_ENST00000540345.1_Missense_Mutation_p.G96R|PDE2A_ENST00000544570.1_Missense_Mutation_p.G98R|PDE2A_ENST00000376450.3_Missense_Mutation_p.G98R|PDE2A_ENST00000540380.1_5'UTR|PDE2A_ENST00000444035.2_Missense_Mutation_p.G96R|PDE2A_ENST00000418754.2_Intron	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	105					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CGGACTTTCCCCTCCTGGGGC	0.572000													23	46					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108409780	108409780	+	Silent	SNP	A	A	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr11:108409780A>G	ENST00000265843.4	-	3	524	c.414T>C	c.(412-414)acT>acC	p.T138T	EXPH5_ENST00000525344.1_Silent_p.T131T|EXPH5_ENST00000428840.1_Silent_p.T62T	NM_015065.2	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5	138					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GAAGCTTTGAAGTCTCCTTTC	0.443000													84	119					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68274236	68274236	+	Silent	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr14:68274236C>T	ENST00000347230.4	-	5	903	c.765G>A	c.(763-765)cgG>cgA	p.R255R	ZFYVE26_ENST00000555452.1_Silent_p.R255R	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	255					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCCGCTCCTCCCGCAGGGGAC	0.622000													33	42					0	0	1	0	0
PDS5A	23244	broad.mit.edu	37	4	39911877	39911877	+	Silent	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr4:39911877C>T	ENST00000303538.8	-	10	1613	c.1074G>A	c.(1072-1074)gcG>gcA	p.A358A	PDS5A_ENST00000503396.1_Silent_p.A358A	NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	358					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						TGAGATCCTTCGCTAAATCTG	0.343000													3	9					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													5	114					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3424149	3424149	+	RNA	SNP	C	C	T	rs112841660		TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr11:3424149C>T	ENST00000529482.1	+	0	808																											TCATAGAGGACGAAGACTTCT	0.562000													3	46					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197791237	197791237	+	Missense_Mutation	SNP	T	T	C	rs149238260		TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:197791237T>C	ENST00000354764.4	-	1	218	c.104A>G	c.(103-105)aAt>aGt	p.N35S	PGAP1_ENST00000409475.1_Missense_Mutation_p.N35S|PGAP1_ENST00000409188.1_Intron|PGAP1_ENST00000485830.1_Intron	NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						ACTGCACTTATTCTCCTCGAA	0.522000													6	460					0	0	1	0	0
PPIC	5480	broad.mit.edu	37	5	122361500	122361500	+	Silent	SNP	A	A	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr5:122361500A>G	ENST00000306442.4	-	4	604	c.489T>C	c.(487-489)ttT>ttC	p.F163F		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	163	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	TGACTTTTCCAAACACCACAT	0.403000													60	73					0	0	1	0	0
DNM1L	10059	broad.mit.edu	37	12	32884346	32884346	+	Silent	SNP	G	G	A			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr12:32884346G>A	ENST00000452533.2	+	11	1421	c.1257G>A	c.(1255-1257)cgG>cgA	p.R419R	DNM1L_ENST00000547312.1_Silent_p.R419R|YARS2_ENST00000551673.1_Intron|DNM1L_ENST00000266481.6_Silent_p.R419R|DNM1L_ENST00000549701.1_Silent_p.R419R|DNM1L_ENST00000381000.4_Silent_p.R432R|DNM1L_ENST00000553257.1_Silent_p.R432R|DNM1L_ENST00000358214.5_Silent_p.R432R|DNM1L_ENST00000414834.2_Silent_p.R216R	NM_012062.3|NM_012063.2	NP_036192.2|NP_036193.2	O00429	DNM1L_HUMAN	dynamin 1-like	419	Middle domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGGTGAAGCGGCAAATCAAAC	0.418000													4	200					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37229591	37229591	+	Silent	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:37229591C>T	ENST00000233099.5	-	32	5270	c.5175G>A	c.(5173-5175)cgG>cgA	p.R1725R	HEATR5B_ENST00000354531.2_Intron	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1725							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GTGGCATATGCCGTACTAAAA	0.478000													5	232					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209165737	209165737	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:209165737A>G	ENST00000264380.4	+	9	1285	c.1127A>G	c.(1126-1128)tAc>tGc	p.Y376C	PIKFYVE_ENST00000308862.6_Missense_Mutation_p.Y290C|PIKFYVE_ENST00000407449.1_Missense_Mutation_p.Y376C|PIKFYVE_ENST00000392202.3_Missense_Mutation_p.Y279C	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	376	DEP.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GATCACCGCTACTGGTTGAGA	0.438000													64	86					0	0	1	0	0
TMX4	56255	broad.mit.edu	37	20	7982176	7982176	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr20:7982176C>T	ENST00000246024.2	-	3	520	c.305G>A	c.(304-306)cGc>cAc	p.R102H	TMX4_ENST00000530935.1_5'UTR	NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	102	Thioredoxin.				cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						GACAAAGAAGCGGCCACTCAA	0.323000													11	21					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76784828	76784828	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr10:76784828A>G	ENST00000287239.4	+	17	3974	c.3485A>G	c.(3484-3486)aAc>aGc	p.N1162S	KAT6B_ENST00000372711.1_Missense_Mutation_p.N979S|KAT6B_ENST00000372724.1_Missense_Mutation_p.N870S|KAT6B_ENST00000372714.1_Missense_Mutation_p.N870S|KAT6B_ENST00000372725.1_Missense_Mutation_p.N870S|RP11-77G23.2_ENST00000413431.1_RNA|KAT6B_ENST00000490365.1_3'UTR	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1162					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CCCTTTGACAACTCAGATGAA	0.483000													46	36					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791718	42791718	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr19:42791718C>T	ENST00000572681.2	+	6	3399	c.3331C>T	c.(3331-3333)Cgg>Tgg	p.R1111W	CIC_ENST00000575354.2_Missense_Mutation_p.R202W|CIC_ENST00000160740.3_Missense_Mutation_p.R202W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	202	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R202W(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CCACATCCGGCGGCCCATGAA	0.622000			"""Mis, F, S"""		oligodendroglioma								39	28					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55399014	55399014	+	Missense_Mutation	SNP	G	G	A	rs150268416		TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr18:55399014G>A	ENST00000536015.1	-	2	145	c.26C>T	c.(25-27)aCg>aTg	p.T9M	RP11-35G9.5_ENST00000588925.1_RNA|RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.T9M	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	9					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				GTCAAATGTCGTTTCTGAGTC	0.428000													6	329					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197791240	197791240	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:197791240T>C	ENST00000354764.4	-	1	215	c.101A>G	c.(100-102)gAg>gGg	p.E34G	PGAP1_ENST00000409475.1_Missense_Mutation_p.E34G|PGAP1_ENST00000409188.1_Intron|PGAP1_ENST00000485830.1_Intron	NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						GCACTTATTCTCCTCGAAGCC	0.522000													6	462					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													6	117					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72663998	72663998	+	RNA	SNP	T	T	G			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr7:72663998T>G	ENST00000425256.1	-	0	902																											ATAGCCGGGGTCCTTGAATAC	0.488000													4	109					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								60	81					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122817533	122817533	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr12:122817533C>T	ENST00000358808.2	-	14	2989		c.e14+1		CLIP1_ENST00000545889.1_Splice_Site|CLIP1_ENST00000361654.4_Splice_Site|CLIP1_ENST00000540338.1_Splice_Site|CLIP1_ENST00000302528.7_Splice_Site|CLIP1_ENST00000537178.1_Splice_Site	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1						mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GTCACATATACCTTTCTTTCA	0.393000													27	51					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96525717	96525718	+	Frame_Shift_Ins	INS	-	-	T	rs77057279	by1000genomes	TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr2:96525717_96525718insT	ENST00000456556.1	-	61	3871_3872	c.3787_3788insA	c.(3787-3789)ctgfs	p.L1263fs	ANKRD36C_ENST00000419039.2_Frame_Shift_Ins_p.L290fs|ANKRD36C_ENST00000420871.2_Frame_Shift_Ins_p.L514fs					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						CTTATTTTTCAGTTTTCGAATT	0.282													4	7	---	---	---	---					
ANKRD30A	91074	broad.mit.edu	37	10	37418878	37418881	+	Frame_Shift_Del	DEL	AGAC	AGAC	-			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr10:37418878_37418881delAGAC	ENST00000374660.1	+	2	210_213	c.111_114delAGAC	c.(109-114)gtagacfs	p.VD37fs	ANKRD30A_ENST00000361713.1_Frame_Shift_Del_p.VD37fs|ANKRD30A_ENST00000602533.1_Frame_Shift_Del_p.VD37fs			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	93						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CATTTCTGGTAGACAGAAAGTGCC	0.456													24	59	---	---	---	---					
VWCE	220001	broad.mit.edu	37	11	61049329	61049329	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A6WE-01A-12D-A33T-08	TCGA-S9-A6WE-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc116e35-9224-47ce-a37e-a8adbf2b3be5	fdf5aabf-afa2-401d-a368-15b5ad44eb7c	g.chr11:61049329delT	ENST00000335613.5	-	7	1102	c.716delA	c.(715-717)aacfs	p.N239fs		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	239	EGF-like 4; calcium-binding (Potential).					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GCCCACGGTGTTGTGGCAGGA	0.627													52	102	---	---	---	---					
