Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PMEL	6490	broad.mit.edu	37	12	56351416	56351416	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr12:56351416G>A	ENST00000548747.1	-	6	1333	c.671C>T	c.(670-672)gCc>gTc	p.A224V	PMEL_ENST00000536427.1_Missense_Mutation_p.A224V|PMEL_ENST00000550464.1_Missense_Mutation_p.A138V|PMEL_ENST00000550447.1_Intron|PMEL_ENST00000449260.2_Missense_Mutation_p.A224V|PMEL_ENST00000539511.1_Missense_Mutation_p.A138V|PMEL_ENST00000548493.1_Missense_Mutation_p.A224V|PMEL_ENST00000552882.1_Missense_Mutation_p.A224V|PMEL_ENST00000360714.4_Missense_Mutation_p.A224V			P40967	PMEL_HUMAN	premelanosome protein	224					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TCCATCCAAGGCCCGCAACTG	0.577000													79	98					0	0	1	0	0
FBL	2091	broad.mit.edu	37	19	40331067	40331067	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:40331067C>T	ENST00000221801.3	-	3	383	c.270G>A	c.(268-270)ccG>ccA	p.P90P		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	90					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CATGCCGATGCGGCTCCACCA	0.622000													5	535					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104048420	104048420	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:104048420A>T	ENST00000374874.3	+	4	726	c.287A>T	c.(286-288)aAa>aTa	p.K96I	LPPR1_ENST00000395056.2_Missense_Mutation_p.K96I	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		96						integral to membrane	catalytic activity										TATTTCATAAAATCAACAAGA	0.388000													52	149					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505814	195505814	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr3:195505814C>T	ENST00000463781.3	-	2	13096	c.12637G>A	c.(12637-12639)Gac>Aac	p.D4213N	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D4213N	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D4213N(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGTGTCGGTGACAGGA	0.597000													3	15					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													4	85					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	24					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28956707	28956707	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr8:28956707T>C	ENST00000524189.1	-	36	4305	c.4267A>G	c.(4267-4269)Ata>Gta	p.I1423V	KIF13B_ENST00000404075.3_5'UTR	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1423					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GCAGGAGCTATTCCTCTGGAA	0.428000													137	80					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110300977	110300977	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr6:110300977C>T	ENST00000414000.2	+	3	946	c.707C>T	c.(706-708)cCg>cTg	p.P236L	GPR6_ENST00000275169.3_Missense_Mutation_p.P221L			P46095	GPR6_HUMAN	G protein-coupled receptor 6	221						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GTGGTGCGCCCGCTGGCGCGC	0.697000													13	16					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53859939	53859939	+	Missense_Mutation	SNP	G	G	A	rs139577103		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr16:53859939G>A	ENST00000471389.1	+	3	509	c.287G>A	c.(286-288)cGc>cAc	p.R96H	FTO_ENST00000394647.3_Intron	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	96	Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						CCGGTATCTCGCATCCTCATT	0.498000													4	148					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51192618	51192618	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:51192618G>A	ENST00000391813.1	-	1	43	c.44C>T	c.(43-45)cCg>cTg	p.P15L	SHANK1_ENST00000359082.3_Intron|SHANK1_ENST00000293441.1_Intron|SHANK1_ENST00000391814.1_Intron			Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1193					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TCCCCCACCCGGCAACCCAGA	0.572000													10	31					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71709086	71709086	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:71709086G>A	ENST00000258104.3	+	3	499	c.222G>A	c.(220-222)acG>acA	p.T74T	DYSF_ENST00000394120.2_Silent_p.T75T|DYSF_ENST00000409582.3_Silent_p.T74T|DYSF_ENST00000410041.1_Silent_p.T75T|DYSF_ENST00000409651.1_Silent_p.T75T|DYSF_ENST00000410020.3_Silent_p.T75T|DYSF_ENST00000409762.1_Silent_p.T74T|DYSF_ENST00000413539.2_Silent_p.T74T|DYSF_ENST00000429174.2_Silent_p.T74T|DYSF_ENST00000409744.1_Silent_p.T75T|DYSF_ENST00000409366.1_Silent_p.T75T	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	74	C2 1.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ACCATGAGACGATGGGGAGGA	0.552000													22	24					0	0	1	0	0
ZMYND19	116225	broad.mit.edu	37	9	140477531	140477531	+	Silent	SNP	C	C	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:140477531C>G	ENST00000298585.2	-	5	670	c.444G>C	c.(442-444)cgG>cgC	p.R148R		NM_138462.2	NP_612471.1	Q96E35	ZMY19_HUMAN	zinc finger, MYND-type containing 19	148						Golgi apparatus|plasma membrane	zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CATTATAATACCGGGTCACAT	0.478000													202	298					0	0	1	0	0
SPIN4	139886	broad.mit.edu	37	X	62570231	62570231	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:62570231G>A	ENST00000374884.2	-	1	992	c.414C>T	c.(412-414)taC>taT	p.Y138Y	SPIN4_ENST00000335144.3_Silent_p.Y156Y|SPIN4-AS1_ENST00000451979.1_RNA			Q56A73	SPIN4_HUMAN	spindlin family, member 4	156					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						GATCTTTCTCGTAGGTGATGT	0.448000													6	234					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25265131	25265131	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr13:25265131G>A	ENST00000218548.6	+	8	1162	c.829G>A	c.(829-831)Ggc>Agc	p.G277S	ATP12A_ENST00000381946.3_Missense_Mutation_p.G271S	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	271					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CACTGTCACCGGCATGGTTAT	0.562000													4	252					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	47000104	47000104	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr10:47000104G>C	ENST00000374314.4	+	1	2179	c.1224G>C	c.(1222-1224)caG>caC	p.Q408H	GPRIN2_ENST00000374317.1_Missense_Mutation_p.Q408H			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	408										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						TGGCCATCCAGAAGCACCTGG	0.672000													4	39					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147830775	147830775	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:147830775G>A	ENST00000354217.2	-	7	1300	c.1137C>T	c.(1135-1137)gaC>gaT	p.D379D	HTR4_ENST00000314512.6_3'UTR|HTR4_ENST00000521735.1_3'UTR|HTR4_ENST00000521530.1_Silent_p.D379D			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	0					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GGGATTCTGGGTCATTGTGTA	0.473000													82	136					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124942	31124942	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr7:31124942G>A	ENST00000304166.4	+	9	843	c.554G>A	c.(553-555)cGc>cAc	p.R185H	ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.R185H|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.R185H|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.R164H	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	185					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CACTGCACACGCAACTTCATC	0.542000													5	407					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183273417	183273417	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr3:183273417C>T	ENST00000341319.3	-	1	60	c.25G>A	c.(25-27)Gcc>Acc	p.A9T		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	9								p.A9T(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ATGGTCCAGGCGCCCCTTTGT	0.587000													131	129					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100284293	100284293	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr7:100284293G>A	ENST00000275732.5	-	7	1882	c.673C>T	c.(673-675)Cgc>Tgc	p.R225C	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	225										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GAGCGCCAGCGGTCGCCGTCT	0.687000													56	212					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1248558	1248558	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr11:1248558C>T	ENST00000447027.1	+	6	655	c.597C>T	c.(595-597)taC>taT	p.Y199Y	MUC5B_ENST00000529681.1_Silent_p.Y199Y			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	199	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ATCCCAAATACGCCAACCAGA	0.637000													9	19					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119677613	119677613	+	Nonsense_Mutation	SNP	T	T	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:119677613T>A	ENST00000371322.5	-	8	1286	c.1225A>T	c.(1225-1227)Aga>Tga	p.R409*	CUL4B_ENST00000404115.3_Nonsense_Mutation_p.R427*|CUL4B_ENST00000336592.6_Nonsense_Mutation_p.R414*	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	427					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTAATAAGTCTGTCTGCTTCT	0.353000													82	102					0	0	1	0	0
LZTS1	11178	broad.mit.edu	37	8	20110916	20110916	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr8:20110916G>A	ENST00000381569.1	-	3	883	c.526C>T	c.(526-528)Cgg>Tgg	p.R176W	LZTS1_ENST00000522290.1_Missense_Mutation_p.R176W|LZTS1_ENST00000265801.6_Missense_Mutation_p.R176W			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	176					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		ATGGAGTTCCGGCCGGAGTCT	0.672000													4	67					0	0	1	0	0
LPAR2	9170	broad.mit.edu	37	19	19737465	19737465	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:19737465C>T	ENST00000542587.1	-	5	1531	c.629G>A	c.(628-630)cGc>cAc	p.R210H	LPAR2_ENST00000586703.1_Missense_Mutation_p.R210H|LPAR2_ENST00000407877.3_Missense_Mutation_p.R210H			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	210					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						GAAGAAAATGCGGGTGTACAC	0.622000													24	120					0	0	1	0	0
DZANK1	55184	broad.mit.edu	37	20	18429670	18429670	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr20:18429670C>A	ENST00000357236.4	-	8	904	c.245G>T	c.(244-246)aGc>aTc	p.S82I	DZANK1_ENST00000358866.6_Missense_Mutation_p.S196I|DZANK1_ENST00000487128.1_5'UTR|DZANK1_ENST00000262547.5_Missense_Mutation_p.S196I|DZANK1_ENST00000329494.5_Missense_Mutation_p.S198I			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1	23						intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						TATCTCCGTGCTTGTCAAACA	0.368000													4	195					1	1	1	1	0
HTR6	3362	broad.mit.edu	37	1	19992358	19992358	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr1:19992358G>A	ENST00000289753.1	+	1	579	c.112G>A	c.(112-114)Gcg>Acg	p.A38T		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	38					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CGTGGTCATCGCGCTGACGGC	0.731000													14	11					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37107434	37107434	+	Splice_Site	SNP	C	C	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr3:37107434C>A	ENST00000421307.1	-	24	1989		c.e24-1		LRRFIP2_ENST00000354379.4_Splice_Site|LRRFIP2_ENST00000336686.4_Splice_Site|LRRFIP2_ENST00000421276.2_Splice_Site|LRRFIP2_ENST00000440230.1_Splice_Site|LRRFIP2_ENST00000396428.2_Splice_Site	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2						Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						AGCCATGTTTCTGCAGGGGGG	0.493000													84	81					2.00703e-41	2.15491e-41	1	1	0
SLC35G3	146861	broad.mit.edu	37	17	33520509	33520509	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:33520509G>A	ENST00000297307.5	-	1	903	c.818C>T	c.(817-819)gCg>gTg	p.A273V		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	273	DUF6 2.					integral to membrane											CTTGGTGACCGCATAGCCCAC	0.592000													5	267					0	0	1	0	0
EPHX4	253152	broad.mit.edu	37	1	92528675	92528675	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr1:92528675C>T	ENST00000370383.4	+	7	1019	c.921C>T	c.(919-921)gaC>gaT	p.D307D		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	307						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						GAGAGAATGACGCATTCATGG	0.418000													21	270					0	0	1	0	0
CD72	971	broad.mit.edu	37	9	35615999	35615999	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:35615999T>C	ENST00000396757.1	-	6	793	c.629A>G	c.(628-630)gAg>gGg	p.E210G	CD72_ENST00000490239.1_5'UTR|CD72_ENST00000259633.4_Missense_Mutation_p.E210G			P21854	CD72_HUMAN	CD72 molecule	210					axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity			large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAGCTTCTGCTCCAAGGCCCT	0.582000													120	137					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115818156	115818156	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:115818156G>A	ENST00000343348.6	-	11	1865	c.1078C>T	c.(1078-1080)Cga>Tga	p.R360*	SEMA6A_ENST00000257414.8_Nonsense_Mutation_p.R360*|CTB-118N6.3_ENST00000514214.1_RNA|CTB-118N6.3_ENST00000508640.1_RNA|SEMA6A_ENST00000510263.1_Nonsense_Mutation_p.R360*|CTB-118N6.3_ENST00000510682.1_RNA	NM_020796.3	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	360	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TTAGGAACTCGTTCATCAGGA	0.423000													20	24					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129649474	129649474	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr6:129649474C>T	ENST00000421865.2	+	29	4277	c.4228C>T	c.(4228-4230)Cct>Tct	p.P1410S		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1410	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGCCGCACCCCTGGACCAAC	0.507000													14	237					0	0	1	0	0
JAGN1	84522	broad.mit.edu	37	3	9934907	9934907	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr3:9934907G>A	ENST00000307768.4	+	2	567	c.398G>A	c.(397-399)gGc>gAc	p.G133D		NM_032492.3	NP_115881.3	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1 (Drosophila)	133						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|lung(3)|ovary(1)	10	Medulloblastoma(99;0.227)					TACCGCCATGGCAAGGCCTAC	0.527000													4	261					0	0	1	0	0
RNF128	79589	broad.mit.edu	37	X	105937249	105937249	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:105937249G>T	ENST00000324342.3	+	1	182	c.17G>T	c.(16-18)aGg>aTg	p.R6M		NM_024539.3	NP_078815.3	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	0						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						CAGGAGAATAGGTCCAGTTTT	0.348000													15	135					2.48551e-13	2.61362e-13	1	1	0
ROR1	4919	broad.mit.edu	37	1	64644134	64644134	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr1:64644134G>A	ENST00000371079.1	+	9	2785	c.2410G>A	c.(2410-2412)Ggt>Agt	p.G804S	ROR1_ENST00000545203.1_Missense_Mutation_p.G255S	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	804	Pro-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						CCAGATTGCTGGTTTCATTGG	0.512000													10	178					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86839366	86839366	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:86839366C>T	ENST00000237455.4	-	3	1366	c.398G>A	c.(397-399)gGc>gAc	p.G133D	AC015971.2_ENST00000597638.1_RNA|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000439077.1_RNA|RNF103-CHMP3_ENST00000604011.1_Intron|CHMP3_ENST00000439940.2_Intron|RNF103_ENST00000477307.1_5'UTR|AC015971.2_ENST00000424788.1_RNA	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	133					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						GTGAATTTTGCCCACCAAGGG	0.388000													4	205					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73399070	73399070	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:73399070G>A	ENST00000377110.3	-	7	1342	c.1099C>T	c.(1099-1101)Cgg>Tgg	p.R367W	TRPM3_ENST00000396280.5_Missense_Mutation_p.R214W|TRPM3_ENST00000377101.1_Missense_Mutation_p.R214W|TRPM3_ENST00000408909.2_Missense_Mutation_p.R214W|TRPM3_ENST00000358082.3_Missense_Mutation_p.R239W|TRPM3_ENST00000361823.5_Missense_Mutation_p.R214W|TRPM3_ENST00000377111.2_Missense_Mutation_p.R367W|TRPM3_ENST00000357533.2_Missense_Mutation_p.R369W|TRPM3_ENST00000396285.1_Missense_Mutation_p.R214W|TRPM3_ENST00000423814.3_Missense_Mutation_p.R394W|TRPM3_ENST00000396283.1_Missense_Mutation_p.R239W|TRPM3_ENST00000396292.4_Missense_Mutation_p.R239W|TRPM3_ENST00000360823.2_Missense_Mutation_p.R239W|TRPM3_ENST00000377106.1_Missense_Mutation_p.R239W|TRPM3_ENST00000377105.1_Missense_Mutation_p.R214W			Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3							integral to membrane	calcium channel activity	p.R239W(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TCCGATGCCCGTCCACTCCCA	0.532000													69	83					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140012294	140012294	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:140012294C>T	ENST00000302014.6	-	2	904	c.275G>A	c.(274-276)cGg>cAg	p.R92Q	CD14_ENST00000401743.2_Missense_Mutation_p.R92Q	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	92					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGAGCCGCCGCACGCGGAG	0.647000													18	71					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69769714	69769714	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:69769714A>T	ENST00000409085.4	-	5	851	c.475T>A	c.(475-477)Tgt>Agt	p.C159S	AAK1_ENST00000409068.1_Missense_Mutation_p.C159S|AAK1_ENST00000470281.1_5'UTR|AAK1_ENST00000406297.3_Missense_Mutation_p.C159S	NM_014911.3	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	159	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						ACAGCTTCACAGGTATCACAA	0.493000													4	192					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123372928	123372928	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr4:123372928G>A	ENST00000226730.4	-	4	725	c.441C>T	c.(439-441)agC>agT	p.S147S		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	147					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TTGAGATGATGCTTTGACAAA	0.303000			T	TNFRSF17	intestinal T-cell lymphoma								17	61					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82337427	82337427	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:82337427A>G	ENST00000376520.4	+	19	2972	c.2144A>G	c.(2143-2145)aAt>aGt	p.N715S	TLE4_ENST00000376534.4_Missense_Mutation_p.N320S|TLE4_ENST00000376552.2_Missense_Mutation_p.N683S|TLE4_ENST00000265284.6_Missense_Mutation_p.N658S|TLE4_ENST00000376544.3_Missense_Mutation_p.N614S|TLE4_ENST00000376537.4_Missense_Mutation_p.N715S	NM_001282748.1	NP_001269677.1	O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GAGAACAGCAATGTGGAAGTT	0.483000													28	65					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576343	33576343	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:33576343G>A	ENST00000504830.1	-	19	4123	c.3788C>T	c.(3787-3789)aCg>aTg	p.T1263M	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.T1178M	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1263	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.T1263M(2)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ACGGTTTGCCGTCTTTCCTGA	0.502000										HNSCC(64;0.19)			161	211					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237891	140237891	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:140237891G>A	ENST00000307360.5	+	1	2258	c.2258G>A	c.(2257-2259)cGg>cAg	p.R753Q	PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018901.2	NP_061724.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGAGGCGGCAGAGGGTG	0.672000													22	29					0	0	1	0	0
ARMCX5	64860	broad.mit.edu	37	X	101858274	101858274	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:101858274C>A	ENST00000604957.1	+	1	3827	c.1205C>A	c.(1204-1206)tCt>tAt	p.S402Y	ARMCX5_ENST00000372742.1_Missense_Mutation_p.S402Y|ARMCX5_ENST00000541409.1_Missense_Mutation_p.S402Y|RP4-769N13.6_ENST00000476910.2_RNA|ARMCX5_ENST00000537008.1_Missense_Mutation_p.S402Y|ARMCX5_ENST00000246174.2_Missense_Mutation_p.S402Y|ARMCX5_ENST00000536530.1_Missense_Mutation_p.S402Y|RP4-769N13.7_ENST00000602441.1_RNA	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	402							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						GGCATAATCTCTTGCCCCTTG	0.423000													15	195					1.37285e-15	1.45866e-15	1	1	0
RFX3	5991	broad.mit.edu	37	9	3257179	3257179	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:3257179G>A	ENST00000382004.3	-	15	1937	c.1626C>T	c.(1624-1626)tgC>tgT	p.C542C	RFX3_ENST00000302303.1_Silent_p.C542C|RFX3_ENST00000358730.2_Silent_p.C542C	NM_001282116.1|NM_134428.1	NP_001269045.1|NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	542					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CATCACACTGGCACACCCAGG	0.483000													4	126					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417287	105417287	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr14:105417287G>A	ENST00000333244.5	-	7	4620	c.4501C>T	c.(4501-4503)Ccg>Tcg	p.P1501S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1501						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGAACGACGGCATCTTGAAC	0.602000													5	612					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130341194	130341194	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr11:130341194C>G	ENST00000299164.2	+	7	1994	c.1994C>G	c.(1993-1995)tCc>tGc	p.S665C		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	665	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AACCTGGGCTCCAAGAAGAGA	0.577000													36	33					0	0	1	0	0
IER3	8870	broad.mit.edu	37	6	30712191	30712191	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr6:30712191G>A	ENST00000376377.2	-	1	134	c.105C>T	c.(103-105)atC>atT	p.I35I	IER3_ENST00000259874.5_Silent_p.I35I			P46695	IEX1_HUMAN	immediate early response 3	35					anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding			NS(1)	1						CGAAGGTGAAGATCTCAGGAC	0.736000													4	13					0	0	1	0	0
GH2	2689	broad.mit.edu	37	17	61957710	61957710	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:61957710G>A	ENST00000423893.2	-	5	686	c.625C>T	c.(625-627)Cgc>Tgc	p.R209C	GH2_ENST00000456543.2_Silent_p.A207A|GH2_ENST00000449787.2_Missense_Mutation_p.R194C|GH2_ENST00000332800.7_3'UTR			P01242	SOM2_HUMAN	growth hormone 2	209						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						TCCACAGAGCGGCACTGCACG	0.607000													24	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650719	179650719	+	Silent	SNP	G	G	A	rs151025677		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:179650719G>A	ENST00000589042.1	-	14	2450	c.2226C>T	c.(2224-2226)tcC>tcT	p.S742S	TTN_ENST00000591111.1_Silent_p.S742S|TTN_ENST00000359218.5_Silent_p.S696S|TTN_ENST00000360870.5_Silent_p.S742S|TTN_ENST00000342992.6_Silent_p.S742S|TTN_ENST00000460472.2_Silent_p.S696S|TTN_ENST00000342175.6_Silent_p.S696S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	742							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.S696S(3)|p.S742S(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTTGCGGCGGAAATGCGTT	0.547000													20	152					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717979	142717979	+	Missense_Mutation	SNP	C	C	T	rs142699085	byFrequency	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:142717979C>T	ENST00000381779.4	-	2	1171	c.946G>A	c.(946-948)Gtt>Att	p.V316I	SLITRK4_ENST00000356928.1_Missense_Mutation_p.V316I|SLITRK4_ENST00000338017.4_Missense_Mutation_p.V316I	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	316						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTGCCTGCAACGATTCCAGAG	0.473000													112	197					0	0	1	0	0
BORA	79866	broad.mit.edu	37	13	73320715	73320715	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr13:73320715C>T	ENST00000390667.5	+	10	1045	c.948C>T	c.(946-948)atC>atT	p.I316I	BORA_ENST00000377815.3_Silent_p.I246I	NM_024808.2	NP_079084.2	Q6PGQ7	BORA_HUMAN	bora, aurora kinase A activator	316					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										ATCCGTGTATCAGAAGTCCTT	0.398000													7	206					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61649048	61649048	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr18:61649048G>A	ENST00000397985.2	+	4	656	c.400G>A	c.(400-402)Gac>Aac	p.D134N	SERPINB8_ENST00000542677.1_5'UTR|SERPINB8_ENST00000397988.3_Missense_Mutation_p.D134N|SERPINB8_ENST00000353706.2_Missense_Mutation_p.D134N	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	134					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				GCATATAAATGACTGGGTGGC	0.438000													50	189					0	0	1	0	0
SLC43A3	29015	broad.mit.edu	37	11	57182153	57182153	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr11:57182153G>A	ENST00000395123.2	-	11	1299	c.995C>T	c.(994-996)gCc>gTc	p.A332V	SLC43A3_ENST00000529554.1_Missense_Mutation_p.A332V|SLC43A3_ENST00000395124.1_Missense_Mutation_p.A332V|SLC43A3_ENST00000352187.1_Missense_Mutation_p.A332V|SLC43A3_ENST00000533524.1_Missense_Mutation_p.A345V	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	332					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						ATTCCAGGGGGCACACAGCAC	0.542000													5	284					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75648839	75648839	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:75648839G>A	ENST00000361470.2	+	1	794	c.516G>A	c.(514-516)acG>acA	p.T172T		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	172	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						GTGAGGGAACGAGCACCTCCG	0.682000													40	47					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159394	18159394	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr11:18159394C>T	ENST00000396275.2	+	3	1006	c.645C>T	c.(643-645)taC>taT	p.Y215Y		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	215						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.Y215Y(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CCAGGCTGTACGTGACCATCC	0.562000													39	30					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35835785	35835785	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:35835785G>A	ENST00000085219.5	+	10	2155	c.2089G>A	c.(2089-2091)Gcc>Acc	p.A697T	CD22_ENST00000419549.2_Missense_Mutation_p.A525T|CD22_ENST00000270311.6_Missense_Mutation_p.A577T|CD22_ENST00000594250.1_Missense_Mutation_p.A520T|CD22_ENST00000536635.2_Missense_Mutation_p.A609T|CD22_ENST00000544992.2_Missense_Mutation_p.A697T|CD22_ENST00000341773.6_Missense_Mutation_p.A520T	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	697					cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GTCCTGCCTCGCCATCCTCAT	0.627000													132	200					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110875	106110875	+	RNA	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr14:106110875C>T	ENST00000390545.2	-	0	252																											TTGTGATCTACGTTGCAGGTG	0.612000													110	106					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14865794	14865794	+	Missense_Mutation	SNP	G	G	A	rs146763976		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:14865794G>A	ENST00000315576.3	-	14	2013	c.1562C>T	c.(1561-1563)gCc>gTc	p.A521V	EMR2_ENST00000353876.1_Missense_Mutation_p.A428V|EMR2_ENST00000594076.1_Missense_Mutation_p.A428V|EMR2_ENST00000601345.1_Missense_Mutation_p.A510V|EMR2_ENST00000346057.1_Missense_Mutation_p.A472V|EMR2_ENST00000392964.3_Silent_p.C185C|EMR2_ENST00000596991.2_Missense_Mutation_p.A510V|EMR2_ENST00000595839.1_Missense_Mutation_p.A379V|EMR2_ENST00000392967.2_Missense_Mutation_p.A510V|EMR2_ENST00000353005.1_Missense_Mutation_p.A379V|EMR2_ENST00000392965.3_Intron|EMR2_ENST00000594294.1_Missense_Mutation_p.A472V	NM_013447.3	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	521	GPS.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.A521V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CATGAGGACGGCAAAGCTGCT	0.572000													4	189					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644511	53644511	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:53644511G>C	ENST00000452676.2	-	5	1999	c.1573C>G	c.(1573-1575)Caa>Gaa	p.Q525E	ZNF347_ENST00000334197.7_Missense_Mutation_p.Q524E|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.Q525E	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TGTGAATTTTGAGTGAAGACC	0.408000													11	428					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130963555	130963555	+	Nonsense_Mutation	SNP	G	G	A	rs138967663		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr12:130963555G>A	ENST00000261655.4	-	3	167	c.4C>T	c.(4-6)Cga>Tga	p.R2*	RIMBP2_ENST00000536002.1_5'UTR|RIMBP2_ENST00000535703.1_5'UTR	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	2						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCCGCCTCTCGCATATGCTGT	0.617000													39	39					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6302235	6302235	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr8:6302235G>A	ENST00000344683.5	+	8	1068	c.992G>A	c.(991-993)cGt>cAt	p.R331H	MCPH1_ENST00000522905.1_Missense_Mutation_p.R283H|MCPH1_ENST00000519480.1_Missense_Mutation_p.R331H	NM_024596.3	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin 1	331						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GAGAAGTATCGTTTGTCTCCT	0.418000													42	23					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82474624	82474624	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr7:82474624G>C	ENST00000333891.9	-	13	14346	c.14009C>G	c.(14008-14010)tCc>tGc	p.S4670C	PCLO_ENST00000423517.2_Missense_Mutation_p.S4670C|PCLO_ENST00000426442.2_5'UTR	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CACTGAGGGGGACCCTGGTTG	0.502000													32	72					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740480	50740480	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr6:50740480C>T	ENST00000008391.3	+	8	1490	c.1262C>T	c.(1261-1263)gCg>gTg	p.A421V		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	421							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					GGCGGAGCGGCGGATTCTGGC	0.498000													43	49					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176824890	176824890	+	Missense_Mutation	SNP	C	C	T	rs148272921		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:176824890C>T	ENST00000324417.5	+	13	1614	c.1523C>T	c.(1522-1524)aCg>aTg	p.T508M	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	508					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGAAACGCACGGCCAAGTAC	0.597000													62	94					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622800	74622800	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:74622800G>A	ENST00000156626.7	-	5	1443	c.1244C>T	c.(1243-1245)gCc>gTc	p.A415V		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	415					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CAGGGAGAAGGCGGTAAAGCC	0.537000													268	334					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128608864	128608864	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr4:128608864T>G	ENST00000335251.6	+	8	1394	c.1291T>G	c.(1291-1293)Ttg>Gtg	p.L431V		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein											breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TGTTCCTCGTTTGGATCATTT	0.443000													10	310					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179196082	179196082	+	Missense_Mutation	SNP	G	G	A	rs144664410	by1000genomes	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:179196082G>A	ENST00000292599.3	+	3	2226	c.1963G>A	c.(1963-1965)Gcg>Acg	p.A655T	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	655					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCACCTTCTCGCGGAACAGGT	0.512000													21	114					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1827422	1827422	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:1827422G>A	ENST00000170168.4	-	2	1460	c.1366C>T	c.(1366-1368)Cgg>Tgg	p.R456W		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	456						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGGCCGCCGCGCTGGCCGG	0.736000													3	20					0	0	1	0	0
ATIC	471	broad.mit.edu	37	2	216198162	216198162	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:216198162G>A	ENST00000435675.1	+	8	1292	c.901G>A	c.(901-903)Gca>Aca	p.A301T	ATIC_ENST00000236959.9_Missense_Mutation_p.A302T|ATIC_ENST00000540518.1_Missense_Mutation_p.A243T			P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	302					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	large_intestine(2)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	8		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CATCTCAGCGGCATATGCAAG	0.403000			T	ALK	ALCL								4	176					0	0	1	0	0
SREBF1	6720	broad.mit.edu	37	17	17718610	17718610	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:17718610C>T	ENST00000355815.4	-	14	2676	c.2507G>A	c.(2506-2508)cGg>cAg	p.R836Q	SREBF1_ENST00000261646.5_Missense_Mutation_p.R806Q|SREBF1_ENST00000338854.5_Missense_Mutation_p.R806Q|SREBF1_ENST00000395757.1_Missense_Mutation_p.R552Q	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	806					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						GAGATGTTCCCGGAATAGCTG	0.617000													56	75					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													4	91					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52695806	52695806	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr12:52695806T>A	ENST00000293525.5	+	1	158	c.106T>A	c.(106-108)Tcc>Acc	p.S36T	KRT86_ENST00000423955.2_Missense_Mutation_p.S36T|KRT86_ENST00000544024.1_Missense_Mutation_p.S36T	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	36	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCGTGGCATCTCCTGCTACCG	0.726000													39	47					0	0	1	0	0
KRT25	147183	broad.mit.edu	37	17	38907516	38907516	+	Silent	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:38907516G>A	ENST00000312150.4	-	4	792	c.732C>T	c.(730-732)ccC>ccT	p.P244P		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	244	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				GGTCCACCCCGGGGGCTGCGT	0.577000													49	79					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451307	155451307	+	Missense_Mutation	SNP	G	G	A	rs146734733		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr6:155451307G>A	ENST00000461783.3	+	6	2223	c.950G>A	c.(949-951)cGc>cAc	p.R317H	TIAM2_ENST00000529824.2_Missense_Mutation_p.R317H|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000456144.1_Missense_Mutation_p.R317H|TIAM2_ENST00000360366.4_Missense_Mutation_p.R317H|TIAM2_ENST00000318981.5_Missense_Mutation_p.R317H			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	317					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TCAGGTATCCGCCTTTCTGAT	0.572000													69	50					0	0	1	0	0
EIF5A	1984	broad.mit.edu	37	17	7214424	7214424	+	Nonsense_Mutation	SNP	A	A	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:7214424A>T	ENST00000336458.8	+	3	654	c.253A>T	c.(253-255)Aaa>Taa	p.K85*	EIF5A_ENST00000416016.2_Nonsense_Mutation_p.K85*|EIF5A_ENST00000571955.1_Nonsense_Mutation_p.K85*|EIF5A_ENST00000572815.1_Nonsense_Mutation_p.K85*|EIF5A_ENST00000419711.2_Nonsense_Mutation_p.K85*|EIF5A_ENST00000576930.1_Nonsense_Mutation_p.K85*|EIF5A_ENST00000336452.7_Nonsense_Mutation_p.K115*|EIF5A_ENST00000573542.1_Nonsense_Mutation_p.K85*	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	85	DOHH-binding.			K -> R (in Ref. 3; AAD14095).	induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						CCCCAACATCAAAAGGAATGA	0.468000													4	222					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012658	6012658	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:6012658T>G	ENST00000259569.5	-	1	2960	c.2950A>C	c.(2950-2952)Ata>Cta	p.I984L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	984					protein transport	cytoplasm|nucleus	binding	p.I984L(4)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTCCCTATTGCTGAGATA	0.363000													4	221					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15695278	15695278	+	Missense_Mutation	SNP	G	G	A	rs139248677	byFrequency	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr9:15695278G>A	ENST00000380701.3	+	11	1589	c.1261G>A	c.(1261-1263)Gtg>Atg	p.V421M	CCDC171_ENST00000297641.3_Missense_Mutation_p.V421M	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	421																	TGAAAATAACGTGAAAGAATT	0.383000													92	136					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947385	237947385	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr1:237947385G>A	ENST00000366574.2	+	90	12690	c.12373G>A	c.(12373-12375)Gtc>Atc	p.V4125I	RYR2_ENST00000609119.1_3'UTR|RYR2_ENST00000542537.1_Missense_Mutation_p.V4109I|RYR2_ENST00000360064.6_Missense_Mutation_p.V4131I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4125					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.V4123I(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCAGAGAGCGTCCTGAATTA	0.512000													48	75					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505813	195505813	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr3:195505813T>C	ENST00000463781.3	-	2	13097	c.12638A>G	c.(12637-12639)gAc>gGc	p.D4213G	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D4213G	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D4213G(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGAGGAAGTGTCGGTGACAGG	0.592000													3	16					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28842379	28842379	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr16:28842379C>A	ENST00000336783.4	+	10	1474	c.1307C>A	c.(1306-1308)cCa>cAa	p.P436Q	ATXN2L_ENST00000395547.2_Missense_Mutation_p.P436Q|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000564304.1_Missense_Mutation_p.P436Q|ATXN2L_ENST00000325215.6_Missense_Mutation_p.P436Q|ATXN2L_ENST00000382686.4_Missense_Mutation_p.P436Q|ATXN2L_ENST00000340394.8_Missense_Mutation_p.P436Q|ATXN2L_ENST00000570200.1_Missense_Mutation_p.P436Q	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	436						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACTTCTGTTCCACCTCCTCCT	0.473000													3	36					1	1	1	1	0
P2RY4	5030	broad.mit.edu	37	X	69478764	69478764	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:69478764C>T	ENST00000374519.2	-	1	890	c.711G>A	c.(709-711)tcG>tcA	p.S237S		NM_002565.3	NP_002556.1	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 4	237					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(2)|endometrium(2)|large_intestine(8)|lung(6)	18						GGCGAGAAGACGACTGTGCAG	0.577000													44	27					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576872	28576872	+	Missense_Mutation	SNP	C	C	T	rs138126171		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr18:28576872C>T	ENST00000434452.1	-	15	2532	c.2378G>A	c.(2377-2379)cGg>cAg	p.R793Q	DSC3_ENST00000360428.4_Missense_Mutation_p.R793Q	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	793					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CCCAGCCCCCCGGCAGGATTC	0.507000													37	59					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41865285	41865285	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr15:41865285G>A	ENST00000263798.3	+	16	2185	c.1961G>A	c.(1960-1962)cGa>cAa	p.R654Q	TYRO3_ENST00000559066.1_Missense_Mutation_p.R609Q	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	654	Protein kinase.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TTCATCCACCGAGACCTGGCT	0.582000													38	54					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27688692	27688692	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr2:27688692C>G	ENST00000260570.3	-	17	1853	c.1750G>C	c.(1750-1752)Ggt>Cgt	p.G584R		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	584					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTAGTCACACCTTCCATCACC	0.517000													312	439					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123516546	123516546	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:123516546T>C	ENST00000422452.2	-	31	7477	c.7414A>G	c.(7414-7416)Aaa>Gaa	p.K2472E	TENM1_ENST00000371130.3_Missense_Mutation_p.K2465E|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TCTTGAGTTTTTGTCTGAAGC	0.363000													131	233					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89592756	89592756	+	Missense_Mutation	SNP	G	G	A	rs147673636		TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr16:89592756G>A	ENST00000268704.2	+	5	653	c.638G>A	c.(637-639)cGa>cAa	p.R213Q	SPG7_ENST00000341316.2_Missense_Mutation_p.R213Q	NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	213					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		TTGATGTACCGAATGCAGGTT	0.532000													4	244					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86199652	86199652	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr12:86199652G>A	ENST00000361228.3	-	2	504	c.136C>T	c.(136-138)Cgc>Tgc	p.R46C		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	46	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAGGTGGTGCGTTTAGTCAGC	0.453000													94	103					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134989501	134989501	+	Nonsense_Mutation	SNP	G	G	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chrX:134989501G>T	ENST00000535938.1	+	9	1074	c.907G>T	c.(907-909)Gag>Tag	p.E303*	SAGE1_ENST00000370709.3_Nonsense_Mutation_p.E303*|SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000324447.3_Nonsense_Mutation_p.E303*	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	303										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					TGTCTGTGAAGAGAAGATGGA	0.428000													5	272					0.0215528	0.0222059	1	1	0
CDHR2	54825	broad.mit.edu	37	5	175995743	175995743	+	Silent	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr5:175995743C>T	ENST00000510636.1	+	4	463	c.189C>T	c.(187-189)agC>agT	p.S63S	CDHR2_ENST00000506348.1_Silent_p.S63S|CDHR2_ENST00000261944.5_Silent_p.S63S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	63	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ATGGGATGAGCGGCCCCAATG	0.612000													4	142					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659536	24659536	+	RNA	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr22:24659536C>T	ENST00000414583.2	+	0	3061					NR_003714.1																						GATCTCATCGCGGACACCACT	0.512000													6	44					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28883967	28883967	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr16:28883967C>T	ENST00000337120.5	+	7	5129	c.1838C>T	c.(1837-1839)tCg>tTg	p.S613L	SH2B1_ENST00000545570.1_Missense_Mutation_p.S303L|SH2B1_ENST00000395532.4_Missense_Mutation_p.S613L|SH2B1_ENST00000563674.1_Intron|SH2B1_ENST00000359285.5_Missense_Mutation_p.S613L|SH2B1_ENST00000538342.1_Missense_Mutation_p.S277L|SH2B1_ENST00000322610.8_Missense_Mutation_p.S613L	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	613	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						CCTTTGGAGTCGGGAGGCTCC	0.612000													61	59					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27682984	27682984	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr1:27682984C>T	ENST00000374040.3	-	25	3768	c.3508G>A	c.(3508-3510)Gaa>Aaa	p.E1170K	MAP3K6_ENST00000493901.1_Missense_Mutation_p.E1178K|MAP3K6_ENST00000357582.2_Missense_Mutation_p.E1178K			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1178					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCCAGGATTTCGCGCAGCCTG	0.627000													25	28					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24771352	24771352	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr8:24771352C>T	ENST00000221166.5	+	1	828	c.46C>T	c.(46-48)Cgg>Tgg	p.R16W	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000518131.1_Missense_Mutation_p.R16W|GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000437366.2_Missense_Mutation_p.R16W			P07197	NFM_HUMAN	neurofilament, medium polypeptide	16	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CGCCTACCGGCGGGTAACCGA	0.701000													13	14					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195264	19195264	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr16:19195264G>A	ENST00000562034.1	+	3	4361	c.563G>A	c.(562-564)cGc>cAc	p.R188H	SYT17_ENST00000568115.1_Missense_Mutation_p.R188H|SYT17_ENST00000562711.2_Missense_Mutation_p.R245H|SYT17_ENST00000355377.2_Missense_Mutation_p.R249H			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	249	C2 1.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GGGGTCAAACGCAAGACCCAG	0.592000													52	159					0	0	1	0	0
BORA	79866	broad.mit.edu	37	13	73319293	73319293	+	Nonsense_Mutation	SNP	C	C	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr13:73319293C>G	ENST00000390667.5	+	8	783	c.686C>G	c.(685-687)tCa>tGa	p.S229*	BORA_ENST00000377815.3_Nonsense_Mutation_p.S159*	NM_024808.2	NP_079084.2	Q6PGQ7	BORA_HUMAN	bora, aurora kinase A activator	229	Ser-rich.				cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										ATGTTTTATTCAATAGATTTG	0.443000													4	227					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38902218	38902218	+	Frame_Shift_Del	DEL	A	A	-			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr7:38902218delA	ENST00000310301.4	-	4	227	c.173delT	c.(172-174)ttgfs	p.L58fs	VPS41_ENST00000395969.2_Frame_Shift_Del_p.L58fs	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	58					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						GCCCAATGCCAAAAACTGTAA	0.308													8	325	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	844731	844732	+	RNA	INS	-	-	G			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr8:844731_844732insG	ENST00000524139.1	+	0	151				ERICH1-AS1_ENST00000578889.1_RNA|ERICH1-AS1_ENST00000577187.1_RNA|ERICH1-AS1_ENST00000522092.1_RNA																							GGTGGCTGGCAGGGCAGGGTGG	0.713													4	2	---	---	---	---					
KIAA0195	9772	broad.mit.edu	37	17	73482037	73482039	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:73482037_73482039delTGC	ENST00000314256.7	+	4	624_626	c.230_232delTGC	c.(229-234)gtgctg>gtg	p.L81del	KIAA0195_ENST00000375248.5_In_Frame_Del_p.L91del|KIAA0195_ENST00000579208.1_Intron	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	81					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTACTGGCCGTGCTGCTGCTGCT	0.675													7	282	---	---	---	---					
LLGL2	3993	broad.mit.edu	37	17	73569700	73569701	+	Frame_Shift_Ins	INS	-	-	G	rs112393371	byFrequency	TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:73569700_73569701insG	ENST00000392550.3	+	21	2981_2982	c.2864_2865insG	c.(2863-2868)ccgagcfs	p.S956fs	LLGL2_ENST00000167462.5_Frame_Shift_Ins_p.S956fs|LLGL2_ENST00000577200.1_Frame_Shift_Ins_p.S956fs	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	956					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AAGAAGGCCCCGAGCCGAGCCA	0.668													9	521	---	---	---	---					
SAP30BP	29115	broad.mit.edu	37	17	73702109	73702109	+	Frame_Shift_Del	DEL	A	A	-			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr17:73702109delA	ENST00000584667.1	+	10	939	c.682delA	c.(682-684)aaafs	p.K229fs	SAP30BP_ENST00000355423.3_Frame_Shift_Del_p.K213fs	NM_013260.6	NP_037392.1	Q9UHR5	S30BP_HUMAN	SAP30 binding protein	229	Thr-rich.				apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)	17	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GACGGGCACCAAAAAAGGcac	0.572													7	545	---	---	---	---					
MYOM1	8736	broad.mit.edu	37	18	3168873	3168873	+	Frame_Shift_Del	DEL	A	A	-			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr18:3168873delA	ENST00000400569.3	-	9	1614	c.1281delT	c.(1279-1281)cgtfs	p.R427fs	MYOM1_ENST00000356443.4_Frame_Shift_Del_p.R427fs|MYOM1_ENST00000261606.7_Frame_Shift_Del_p.R427fs			P52179	MYOM1_HUMAN	myomesin 1	427	Ig-like C2-type 2.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TGATGACAACACGACAGCCTA	0.428													34	53	---	---	---	---					
BTBD3	22903	broad.mit.edu	37	20	11899098	11899100	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-S9-A6WM-01A-12D-A33T-08	TCGA-S9-A6WM-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe1567be-1cc2-4ee2-a3fa-44c4a4d5b643	7710113a-645a-4c0c-a3a4-48eb1885b66d	g.chr20:11899098_11899100delAAG	ENST00000405977.1	+	2	800_802	c.175_177delAAG	c.(175-177)aagdel	p.K61del	RP4-742J24.2_ENST00000439529.1_RNA|BTBD3_ENST00000378226.2_In_Frame_Del_p.K61del|BTBD3_ENST00000254977.3_5'UTR|BTBD3_ENST00000399006.2_5'UTR	NM_001282550.1|NM_001282552.1|NM_001282554.1	NP_001269479.1|NP_001269481.1|NP_001269483.1	Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	61										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						GAAGACTAAAAAGAAGAAGATGG	0.453													129	300	---	---	---	---					
