Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GKN2	200504	broad.mit.edu	37	2	69173459	69173459	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:69173459T>G	ENST00000481498.1	-	5	467	c.449A>C	c.(448-450)aAg>aCg	p.K150T	GKN2_ENST00000328895.4_Missense_Mutation_p.K150T			Q86XP6	GKN2_HUMAN	gastrokine 2	150	BRICHOS.					extracellular region		p.K150T(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	15						CACTTCCCCCTTATACAAAGG	0.453000													27	63					0	0	0.693898	0	0
CD163L1	283316	broad.mit.edu	37	12	7526177	7526177	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:7526177C>G	ENST00000313599.3	-	14	3526	c.3469G>C	c.(3469-3471)Gaa>Caa	p.E1157Q	CD163L1_ENST00000416109.2_Missense_Mutation_p.E1167Q|CD163L1_ENST00000396630.1_Missense_Mutation_p.E1157Q			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1157	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity	p.E1157Q(1)		breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TAGAAGACTTCCAATCTCCCA	0.488000													20	135					0	0	0.667858	0	0
TRIM58	25893	broad.mit.edu	37	1	248039632	248039632	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:248039632C>G	ENST00000366481.3	+	6	1350	c.1302C>G	c.(1300-1302)taC>taG	p.Y434*	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	434	B30.2/SPRY.					intracellular	zinc ion binding	p.Y434*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTTATATCTACACATTCAACC	0.433000													87	122					0	0	0.870114	0	0
PARPBP	55010	broad.mit.edu	37	12	102569349	102569349	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:102569349G>A	ENST00000327680.2	+	8	1130	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K	PARPBP_ENST00000543784.1_Intron|PARPBP_ENST00000392911.2_Missense_Mutation_p.E223K|PARPBP_ENST00000378128.3_Intron|PARPBP_ENST00000358383.5_Missense_Mutation_p.E304K|PARPBP_ENST00000541394.1_Missense_Mutation_p.E381K|PARPBP_ENST00000535811.1_Intron	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	304					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding	p.E304K(1)|p.E223K(1)		endometrium(1)|lung(8)|urinary_tract(2)	11						AGCAATAGAGGAAGTTGCTCA	0.398000													23	37					0	0	0.654019	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723793	140723793	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:140723793C>T	ENST00000253812.6	+	1	193	c.193C>T	c.(193-195)Cgc>Tgc	p.R65C	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.R65C(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTCCGCATCGTCTC	0.617000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	113					0	0	0.278610	0	0
EGF	1950	broad.mit.edu	37	4	110914495	110914495	+	Missense_Mutation	SNP	C	C	T	rs144527372		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr4:110914495C>T	ENST00000265171.5	+	19	3272	c.2827C>T	c.(2827-2829)Cgc>Tgc	p.R943C	EGF_ENST00000503392.1_Intron|EGF_ENST00000509793.1_Missense_Mutation_p.R901C	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	943	EGF-like 8; calcium-binding (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity	p.R943C(2)		breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTGTGCTGGACGCCTGTCTGA	0.527000													17	64					0	0	0.520397	0	0
TENM2	57451	broad.mit.edu	37	5	167671581	167671581	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:167671581G>A	ENST00000519204.1	+	25	5432	c.5314G>A	c.(5314-5316)Gtg>Atg	p.V1772M	TENM2_ENST00000403607.2_Missense_Mutation_p.V1717M|TENM2_ENST00000518659.1_Missense_Mutation_p.V1893M|TENM2_ENST00000520394.1_Missense_Mutation_p.V1654M|TENM2_ENST00000545108.1_Missense_Mutation_p.V1892M					teneurin transmembrane protein 2									p.V1893M(1)|p.V1772M(1)|p.V1726M(1)									AGCTGTCAACGTGTCATACTT	0.597000													3	51					0	0	0.115264	0	0
FOXP2	93986	broad.mit.edu	37	7	114282647	114282647	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:114282647C>A	ENST00000393500.3	+	13	1553	c.733C>A	c.(733-735)Cag>Aag	p.Q245K	FOXP2_ENST00000378237.3_Missense_Mutation_p.Q320K|FOXP2_ENST00000403559.4_Missense_Mutation_p.Q337K|FOXP2_ENST00000393494.2_Missense_Mutation_p.Q320K|FOXP2_ENST00000350908.4_Missense_Mutation_p.Q320K|FOXP2_ENST00000408937.3_Missense_Mutation_p.Q345K|FOXP2_ENST00000360232.4_Missense_Mutation_p.Q320K|FOXP2_ENST00000393498.2_Missense_Mutation_p.Q299K|FOXP2_ENST00000393489.3_Missense_Mutation_p.Q228K|FOXP2_ENST00000390668.3_Missense_Mutation_p.Q344K|FOXP2_ENST00000393491.3_Missense_Mutation_p.Q228K			O15409	FOXP2_HUMAN	forkhead box P2	320	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q345K(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AGTGAATGGACAGTCTTCAGT	0.388000													8	74					0.00448238	0.00502027	0.307466	1	0
GRID1	2894	broad.mit.edu	37	10	87487760	87487760	+	Missense_Mutation	SNP	C	C	T	rs149107262		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:87487760C>T	ENST00000327946.7	-	10	1470	c.1385G>A	c.(1384-1386)cGc>cAc	p.R462H	GRID1_ENST00000536331.1_Missense_Mutation_p.R33H	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	462						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.R462H(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CCCTTTGTAGCGCTTGGGCTG	0.488000										Multiple Myeloma(13;0.14)			11	100					0	0	0.387290	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56807778	56807778	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:56807778C>T	ENST00000413728.2	-	2	724	c.181G>A	c.(181-183)Gtg>Atg	p.V61M	ARHGEF3_ENST00000338458.4_Missense_Mutation_p.V87M|ARHGEF3_ENST00000498517.1_5'UTR|ARHGEF3_ENST00000497267.1_Missense_Mutation_p.V26M|ARHGEF3_ENST00000496106.1_Missense_Mutation_p.V61M|ARHGEF3_ENST00000495373.1_Missense_Mutation_p.V55M|ARHGEF3_ENST00000296315.3_Missense_Mutation_p.V55M	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	55					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity	p.V55M(2)|p.V87M(1)		cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GTGGCCTTCACGGGCGGGATG	0.478000													3	12					0	0	0.184627	0	0
NAT10	55226	broad.mit.edu	37	11	34153690	34153690	+	Silent	SNP	T	T	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:34153690T>C	ENST00000257829.3	+	15	1745	c.1539T>C	c.(1537-1539)gaT>gaC	p.D513D	NAT10_ENST00000531159.2_Silent_p.D441D|NAT10_ENST00000527971.1_Intron	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	513						nucleolus	ATP binding|N-acetyltransferase activity|protein binding	p.D513D(1)		endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TTAATAGAGATACCCTCTTTT	0.458000													52	298					0	0	0.870114	0	0
RYR1	6261	broad.mit.edu	37	19	38951104	38951104	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:38951104G>A	ENST00000355481.4	+	20	2581	c.2450G>A	c.(2449-2451)cGa>cAa	p.R817Q	RYR1_ENST00000360985.3_Missense_Mutation_p.R817Q|RYR1_ENST00000359596.3_Missense_Mutation_p.R817Q	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	817					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R817Q(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGCTCCCTCGAGAGCGACTC	0.632000													22	69					0	0	0.681144	0	0
CFH	3075	broad.mit.edu	37	1	196706690	196706690	+	Silent	SNP	G	G	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:196706690G>C	ENST00000367429.4	+	17	2922	c.2682G>C	c.(2680-2682)ggG>ggC	p.G894G		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	894	Sushi 15.				complement activation, alternative pathway	extracellular space		p.G894G(1)		NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ATGCACATGGGACTAAATTGA	0.383000													14	18					0	0	0.435327	0	0
GRID1	2894	broad.mit.edu	37	10	87487669	87487669	+	Silent	SNP	G	G	A	rs149876378		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:87487669G>A	ENST00000327946.7	-	10	1561	c.1476C>T	c.(1474-1476)taC>taT	p.Y492Y	GRID1_ENST00000536331.1_Silent_p.Y63Y	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	492						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.Y492Y(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCTGGTGACCGTACCTGCCAT	0.557000										Multiple Myeloma(13;0.14)			23	53					0	0	0.681144	0	0
SPAM1	6677	broad.mit.edu	37	7	123594255	123594255	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:123594255C>T	ENST00000340011.5	+	3	988	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W	SPAM1_ENST00000402183.2_Missense_Mutation_p.R211W|SPAM1_ENST00000439500.1_Missense_Mutation_p.R211W|SPAM1_ENST00000223028.7_Missense_Mutation_p.R211W|SPAM1_ENST00000460182.1_Missense_Mutation_p.R211W	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	211					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity	p.R211W(2)		breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AAAATTACTTCGGCCAAATCA	0.378000													8	69					0	0	0.278610	0	0
NCOR2	9612	broad.mit.edu	37	12	124840077	124840077	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:124840077G>A	ENST00000356219.3	-	25	3458	c.3303C>T	c.(3301-3303)ccC>ccT	p.P1101P	NCOR2_ENST00000397355.1_Silent_p.P1085P|NCOR2_ENST00000405201.1_Silent_p.P1094P|NCOR2_ENST00000429285.2_Silent_p.P1084P|NCOR2_ENST00000404621.1_Silent_p.P1084P|NCOR2_ENST00000404121.2_Silent_p.P655P	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1102					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.P1094P(1)|p.P1101P(1)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGGCAGGACGGGCCGGGCAG	0.667000													12	19					0	0	0.387290	0	0
LAMA5	3911	broad.mit.edu	37	20	60889674	60889674	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:60889674G>A	ENST00000252999.3	-	61	8370	c.8304C>T	c.(8302-8304)ggC>ggT	p.G2768G		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2768	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding	p.G2768G(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGCTCTGGGCCCTGCAGGT	0.647000													10	47					0	0	0.361761	0	0
MARCO	8685	broad.mit.edu	37	2	119752091	119752091	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:119752091G>A	ENST00000541757.1	+	18	1704	c.1324G>A	c.(1324-1326)Gtc>Atc	p.V442I	MARCO_ENST00000327097.4_Missense_Mutation_p.V520I			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	520	SRCR.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.V520I(3)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GGAGTGCAGCGTCTGACCCGG	0.602000													13	44					0	0	0.539581	0	0
SCAF4	57466	broad.mit.edu	37	21	33073368	33073368	+	Silent	SNP	T	T	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr21:33073368T>C	ENST00000286835.7	-	7	1099	c.717A>G	c.(715-717)acA>acG	p.T239T	SCAF4_ENST00000434667.3_Silent_p.T224T|SCAF4_ENST00000399804.1_Silent_p.T239T	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	239						nucleus	nucleotide binding|RNA binding	p.T239T(1)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CAGATGGTTGTGTAGGAGTTG	0.448000													8	30					0	0	0.335167	0	0
PHKB	5257	broad.mit.edu	37	16	47549445	47549445	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr16:47549445C>T	ENST00000455779.1	+	7	691	c.506C>T	c.(505-507)tCa>tTa	p.S169L	PHKB_ENST00000323584.5_Missense_Mutation_p.S176L|PHKB_ENST00000566044.1_Missense_Mutation_p.S169L|PHKB_ENST00000567402.1_3'UTR|PHKB_ENST00000299167.8_Missense_Mutation_p.S176L			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	176					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity	p.S176L(2)|p.S169L(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AATGCAGTGTCACTTTATCTC	0.313000													9	26					0	0	0.335167	0	0
SLC25A10	1468	broad.mit.edu	37	17	79687107	79687107	+	Nonstop_Mutation	SNP	A	A	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:79687107A>C	ENST00000331531.5	+	11	1011	c.891A>C	c.(889-891)tgA>tgC	p.*297C	SLC25A10_ENST00000541223.1_Nonstop_Mutation_p.*443C|SLC25A10_ENST00000571730.1_Nonstop_Mutation_p.*443C|SLC25A10_ENST00000350690.5_Nonstop_Mutation_p.*288C|SLC25A10_ENST00000545862.1_Nonstop_Mutation_p.*245C	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding	p.*288C(1)		endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGCCATCCTGACCAGCCGTGG	0.607000													7	27					0	0	0.435327	0	0
TTLL9	164395	broad.mit.edu	37	20	30522516	30522516	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:30522516C>T	ENST00000375938.4	+	12	1082	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C	TTLL9_ENST00000375922.4_Missense_Mutation_p.R219C|TTLL9_ENST00000375921.2_Intron|TTLL9_ENST00000375934.4_Silent_p.S244S|TTLL9_ENST00000310998.4_Missense_Mutation_p.R242C|TTLL9_ENST00000535842.1_Missense_Mutation_p.R277C			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	277	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity	p.R277C(1)|p.R266C(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GACGCTGCAGCGCTTCCGGCA	0.607000													4	15					0	0	0.217242	0	0
CSF3R	1441	broad.mit.edu	37	1	36932904	36932904	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:36932904T>C	ENST00000373103.1	-	16	2514	c.1967A>G	c.(1966-1968)aAt>aGt	p.N656S	CSF3R_ENST00000418048.2_Missense_Mutation_p.N656S|CSF3R_ENST00000361632.4_Missense_Mutation_p.N656S|CSF3R_ENST00000331941.5_Missense_Mutation_p.N656S|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000373106.1_Missense_Mutation_p.N656S|CSF3R_ENST00000373104.1_Missense_Mutation_p.N656S|CSF3R_ENST00000338937.5_Missense_Mutation_p.I625V|CSF3R_ENST00000440588.2_Missense_Mutation_p.N656S	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	656					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity	p.N656S(2)		central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCAGAGGGGATTCTTCCTGCT	0.592000													54	67					0	0	0.870114	0	0
PROKR2	128674	broad.mit.edu	37	20	5283319	5283319	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr20:5283319G>A	ENST00000546004.1	-	3	768	c.522C>T	c.(520-522)atC>atT	p.I174I	PROKR2_ENST00000217270.3_Silent_p.I174I			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	174						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.I174I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						AGACCAAGGCGATCAGGAAGG	0.488000										HNSCC(71;0.22)			5	76					0	0	0.184627	0	0
KRT7	3855	broad.mit.edu	37	12	52639248	52639248	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr12:52639248C>T	ENST00000331817.5	+	7	1220	c.1037C>T	c.(1036-1038)gCg>gTg	p.A346V	KRT7_ENST00000552322.1_3'UTR|RP3-416H24.1_ENST00000546686.1_RNA	NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	346	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity	p.A346V(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		GGGGAGCTGGCGCTCAAGGAT	0.647000													6	23					0	0	0.248553	0	0
CBWD6	644019	broad.mit.edu	37	9	69247529	69247529	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr9:69247529G>A	ENST00000377457.5	-	5	588	c.483C>T	c.(481-483)taC>taT	p.Y161Y	CBWD6_ENST00000382399.4_Intron|CBWD6_ENST00000377449.1_Silent_p.Y125Y	NM_001085457.1	NP_001078926.1	Q4V339	CBWD6_HUMAN	COBW domain containing 6	161							ATP binding	p.Y161Y(1)		lung(4)	4						TACCATCAAGGTAAATATCAC	0.299000													3	18					0	0	0.115264	0	0
CIRBP	1153	broad.mit.edu	37	19	1270962	1270962	+	Silent	SNP	T	T	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:1270962T>G	ENST00000589710.1	+	2	177	c.30T>G	c.(28-30)gtT>gtG	p.V10V	CIRBP_ENST00000589235.1_Silent_p.V10V|CIRBP_ENST00000588030.1_Silent_p.V10V|CIRBP_ENST00000587896.1_Silent_p.V10V|CIRBP_ENST00000591935.1_Silent_p.V10V|CIRBP_ENST00000588090.1_Silent_p.V10V|CIRBP_ENST00000586472.1_Silent_p.V10V|CIRBP_ENST00000444172.2_5'UTR|CIRBP_ENST00000320936.5_Silent_p.V10V|CIRBP_ENST00000586773.1_Silent_p.V10V|CIRBP_ENST00000587323.1_Silent_p.V10V|CIRBP_ENST00000589660.1_Silent_p.V10V|CIRBP_ENST00000585630.1_Silent_p.V10V|CIRBP_ENST00000589686.1_Silent_p.V10V|CIRBP_ENST00000413636.2_Silent_p.V10V|CIRBP_ENST00000588230.1_Silent_p.V10V			Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	10	RRM.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity	p.V10V(1)		endometrium(1)|large_intestine(1)|lung(3)	5		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		aactttttgttggagggctga	0.557000													13	140					0	0	0.435327	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													6	15					0	0	0.248553	0	0
CCSER1	401145	broad.mit.edu	37	4	91549259	91549259	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr4:91549259C>A	ENST00000509176.1	+	6	2096	c.1808C>A	c.(1807-1809)gCg>gAg	p.A603E	CCSER1_ENST00000333691.8_Missense_Mutation_p.A603E|CCSER1_ENST00000432775.2_Missense_Mutation_p.A603E	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1									p.A603E(2)|p.A605E(1)									AGTCCATCTGCGGATTGGCCT	0.443000													3	37					0.115264	0.121788	0.115264	1	0
ALX4	60529	broad.mit.edu	37	11	44297153	44297153	+	Silent	SNP	C	C	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:44297153C>A	ENST00000329255.3	-	2	625	c.522G>T	c.(520-522)ggG>ggT	p.G174G		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	174					hair follicle development			p.G174G(1)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						TGCTGTCCATCCCCACAGTGT	0.587000													34	52					1.22384e-17	1.45819e-17	0.769981	1	0
GARNL3	84253	broad.mit.edu	37	9	130027251	130027251	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr9:130027251G>A	ENST00000373387.4	+	1	447	c.95G>A	c.(94-96)gGc>gAc	p.G32D	GARNL3_ENST00000435213.2_Missense_Mutation_p.G10D|GARNL3_ENST00000314904.5_Missense_Mutation_p.G32D	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	32					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity	p.G14D(1)		NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						GAAGACCTAGGCTGTAGACGT	0.408000													20	122					0	0	0.639603	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430990	37430990	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr10:37430990G>T	ENST00000374660.1	+	7	1096	c.997G>T	c.(997-999)Gaa>Taa	p.E333*	ANKRD30A_ENST00000602533.1_Nonsense_Mutation_p.E333*|ANKRD30A_ENST00000361713.1_Nonsense_Mutation_p.E333*			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	389						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.E333*(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGAGAAAAAAGAAGACACACC	0.428000													14	33					1.52009e-12	1.77344e-12	0.479597	1	0
CENPN	55839	broad.mit.edu	37	16	81056432	81056432	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr16:81056432G>T	ENST00000299572.5	+	7	1340	c.604G>T	c.(604-606)Gct>Tct	p.A202S	CENPN_ENST00000428963.2_Intron|CENPN_ENST00000393335.3_Intron|CENPN_ENST00000439957.3_Intron|RP11-303E16.3_ENST00000562315.1_RNA|CENPN_ENST00000305850.5_Intron	NM_018455.5	NP_060925.2	Q96H22	CENPN_HUMAN	centromere protein N	0					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm		p.A202S(1)		breast(1)|large_intestine(5)|lung(4)	10						AATGAAGAAAGCTTGCAATTA	0.333000													3	46					0.115264	0.121788	0.115264	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													3	53					0	0	0.115264	0	0
SYNE3	161176	broad.mit.edu	37	14	95932465	95932465	+	Silent	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr14:95932465G>A	ENST00000334258.5	-	3	444	c.430C>T	c.(430-432)Ctg>Ttg	p.L144L	SYNE3_ENST00000553340.1_Silent_p.L144L|SYNE3_ENST00000557275.1_Silent_p.L144L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3									p.L144L(3)		breast(1)|endometrium(2)|lung(25)	28						TTCAGGCCCAGCTGGAGCTCG	0.637000													32	41					0	0	0.750413	0	0
EHF	26298	broad.mit.edu	37	11	34668230	34668230	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:34668230C>G	ENST00000527935.1	+	2	346	c.342C>G	c.(340-342)aaC>aaG	p.N114K	EHF_ENST00000531728.1_Missense_Mutation_p.N114K|EHF_ENST00000533754.1_Splice_Site_p.N114_splice|EHF_ENST00000530286.1_Splice_Site_p.N114_splice|EHF_ENST00000531794.1_Splice_Site_p.N136_splice|EHF_ENST00000450654.2_Splice_Site_p.N114_splice|EHF_ENST00000257831.3_Splice_Site_p.N114_splice			Q9NZC4	EHF_HUMAN	ets homologous factor	114	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.N114K(1)	NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TGAAGTGGAACGGTGACTCTC	0.557000													26	107					0	0	0.729181	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503027	140503027	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr5:140503027G>A	ENST00000194152.1	+	1	1447	c.1447G>A	c.(1447-1449)Gcc>Acc	p.A483T		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		483	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding	p.A483T(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCACCAACGCCCAGGTCAC	0.657000													16	61					0	0	0.575678	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651781	121651781	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr7:121651781G>A	ENST00000393386.2	+	12	3092	c.2681G>A	c.(2680-2682)aGt>aAt	p.S894N	PTPRZ1_ENST00000483028.1_Intron|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	894					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.S894N(2)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GAATTTGGTAGTGAATCTGGT	0.478000													16	30					0	0	0.500413	0	0
BMP15	9210	broad.mit.edu	37	X	50659038	50659038	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chrX:50659038C>T	ENST00000252677.3	+	2	610	c.610C>T	c.(610-612)Cga>Tga	p.R204*		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	204					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity	p.R204*(2)		NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					CAGGATCCTACGACTCCGTTT	0.438000													16	25					0	0	0.520397	0	0
TMX2	51075	broad.mit.edu	37	11	57480103	57480103	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr11:57480103G>C	ENST00000278422.4	+	1	25	c.13G>C	c.(13-15)Gca>Cca	p.A5P	TMX2-CTNND1_ENST00000528395.1_Missense_Mutation_p.A5P|TMX2_ENST00000378312.4_Missense_Mutation_p.A5P	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	5					cell redox homeostasis	integral to membrane		p.A5P(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						GGCGGTCTTGGCACCTCTAAT	0.597000													5	15					0	0	0.217242	0	0
SMAD4	4089	broad.mit.edu	37	18	48604655	48604655	+	Missense_Mutation	SNP	G	G	A	rs121912578		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr18:48604655G>A	ENST00000342988.3	+	12	2015	c.1477G>A	c.(1477-1479)Gat>Aat	p.D493N	SMAD4_ENST00000588745.1_Missense_Mutation_p.D397N|SMAD4_ENST00000586253.1_3'UTR|SMAD4_ENST00000398417.2_Missense_Mutation_p.D493N	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	493	MH2.		D -> H (in pancreatic carcinoma; dbSNP:rs28936392).		BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)|p.D493N(2)|p.D493H(1)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		AATTGGTGTTGATGACCTTCG	0.463000													11	19					0	0	0.435327	0	0
FPR1	2357	broad.mit.edu	37	19	52249869	52249869	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr19:52249869C>T	ENST00000595042.1	-	3	520	c.379G>A	c.(379-381)Gtc>Atc	p.V127I	FPR1_ENST00000304748.4_Missense_Mutation_p.V127I	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	127					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.V127I(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGATGCAGGACGCAAACACAG	0.557000													15	35					0	0	0.575678	0	0
LOC645752	645752	broad.mit.edu	37	15	78212618	78212618	+	RNA	SNP	A	A	G			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr15:78212618A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TGTAACCGCCACTGGAGGACC	0.562000													3	35					0	0	0.115264	0	0
STAT1	6772	broad.mit.edu	37	2	191873763	191873763	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:191873763G>A	ENST00000361099.3	-	4	586	c.199C>T	c.(199-201)Caa>Taa	p.Q67*	STAT1_ENST00000392322.3_Nonsense_Mutation_p.Q67*|STAT1_ENST00000540176.1_Nonsense_Mutation_p.Q67*|STAT1_ENST00000392323.2_Nonsense_Mutation_p.Q69*|STAT1_ENST00000409465.1_Nonsense_Mutation_p.Q67*	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	67					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity	p.Q67*(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	CGACTATATTGATCATCCAGC	0.388000													8	20					0	0	0.307466	0	0
MGAT5B	146664	broad.mit.edu	37	17	74921106	74921106	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:74921106G>A	ENST00000569840.2	+	9	1658	c.1084G>A	c.(1084-1086)Gac>Aac	p.D362N	MGAT5B_ENST00000301618.4_Missense_Mutation_p.D362N|MGAT5B_ENST00000428789.2_Missense_Mutation_p.D373N	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	362						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding	p.D362N(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTGCCCTTCGACCTCATCTA	0.617000													15	62					0	0	0.500413	0	0
PXDN	7837	broad.mit.edu	37	2	1653369	1653369	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:1653369C>T	ENST00000252804.4	-	17	2233	c.2183G>A	c.(2182-2184)cGc>cAc	p.R728H		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	728					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity	p.R728H(1)		breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTTGTTCACGCGCCGGTGGGC	0.602000													4	61					0	0	0.150653	0	0
IGHM	3507	broad.mit.edu	37	14	106320511	106320511	+	RNA	SNP	G	G	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr14:106320511G>A	ENST00000390559.2	-	0	1298																											TGGGTTTACCGGTGGACTTGT	0.647000													7	58					0	0	0.278610	0	0
COL6A3	1293	broad.mit.edu	37	2	238280738	238280738	+	Missense_Mutation	SNP	G	G	A	rs140330124		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr2:238280738G>A	ENST00000295550.4	-	9	4374	c.3922C>T	c.(3922-3924)Cgg>Tgg	p.R1308W	COL6A3_ENST00000392003.2_Missense_Mutation_p.R901W|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1102W|COL6A3_ENST00000472056.1_Missense_Mutation_p.R701W|COL6A3_ENST00000353578.4_Missense_Mutation_p.R1102W|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1107W|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1108W|COL6A3_ENST00000392004.3_Missense_Mutation_p.R1102W	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1308	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R1102W(1)|p.R1308W(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGATCTGCCGCCCTCCCTTG	0.617000													4	42					0	0	0.184627	0	0
KLHL21	9903	broad.mit.edu	37	1	6655560	6655561	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr1:6655560_6655561insA	ENST00000377663.3	-	3	1667_1668	c.1484_1485insT	c.(1483-1485)accfs	p.T495fs	KLHL21_ENST00000463043.1_Frame_Shift_Ins_p.T128fs|KLHL21_ENST00000377658.4_Frame_Shift_Ins_p.T495fs|KLHL21_ENST00000467612.1_Frame_Shift_Ins_p.T128fs			Q9UJP4	KLH21_HUMAN	kelch-like family member 21	495					anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|prostate(2)	8	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		TCATGGACGGGATCTTGTCCCA	0.554													9	23	---	---	---	---					
DNAJC13	23317	broad.mit.edu	37	3	132182659	132182662	+	Splice_Site	DEL	TAGG	TAGG	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:132182659_132182662delTAGG	ENST00000260818.6	+	17	2138_2140	c.1892_splice	c.e17+1	p.K630_splice	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	630							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TGCTTACAAATAGGTAGGTGATTT	0.353													10	77	---	---	---	---					
SLC35G2	80723	broad.mit.edu	37	3	136573486	136573486	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr3:136573486delA	ENST00000446465.2	+	2	812	c.184delA	c.(184-186)aafs	p.K64fs	RP11-85F14.5_ENST00000474250.1_RNA|SLC35G2_ENST00000393079.3_Frame_Shift_Del_p.K64fs|RP11-85F14.5_ENST00000461864.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	64						Golgi apparatus|integral to membrane											GAGTGAAATGAAAAAAAAAGG	0.413													8	139	---	---	---	---					
ZDHHC14	79683	broad.mit.edu	37	6	157803062	157803064	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr6:157803062_157803064delCGG	ENST00000359775.5	+	1	898_900	c.9_11delCGG	c.(7-12)ccc>cc	p.PG3del	ZDHHC14_ENST00000414563.2_In_Frame_Del_p.PG3del			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	3						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGATGCCTCCCGGCGGCGGCGGG	0.754													2	4	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32077916	32077917	+	RNA	INS	-	-	TTTT	rs139112308	by1000genomes	TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr16:32077916_32077917insTTTT	ENST00000566806.1	-	0	499																											ATGGAAAACGGTTATTTTTTTG	0.421													2	4	---	---	---	---					
RNF43	54894	broad.mit.edu	37	17	56440903	56440904	+	Frame_Shift_Ins	INS	-	-	AT	rs151209912		TCGA-05-5429-01A-01D-1625-08	TCGA-05-5429-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37d0cf1b-1743-4852-8073-372b16b5c17d	feaed996-83e7-46af-9e74-3d70b303ea6a	g.chr17:56440903_56440904insAT	ENST00000584437.1	-	3	2388_2389	c.433_434insAT	c.(433-435)agcfs	p.S145fs	RNF43_ENST00000583753.1_Frame_Shift_Ins_p.S104fs|RNF43_ENST00000577716.1_Frame_Shift_Ins_p.S145fs|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000577625.1_Frame_Shift_Ins_p.S18fs|RNF43_ENST00000581868.1_Frame_Shift_Ins_p.S18fs|RNF43_ENST00000500597.2_Frame_Shift_Ins_p.S104fs|RNF43_ENST00000407977.2_Frame_Shift_Ins_p.S145fs			Q68DV7	RNF43_HUMAN	ring finger protein 43	145						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding	p.R145*(1)		NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCAGCAGCTCGATCCTCAGTG	0.594													16	152	---	---	---	---					
