Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DLEC1	9940	broad.mit.edu	37	3	38080913	38080913	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:38080913T>A	ENST00000308059.6	+	1	218	c.197T>A	c.(196-198)cTc>cAc	p.L66H	DLEC1_ENST00000346219.3_Missense_Mutation_p.L66H|DLEC1_ENST00000452631.2_Missense_Mutation_p.L66H			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	66					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCCCGCCGCCTCACGCAGCTT	0.672000													11	27					0	0	0.018920	0	0
PAX1	5075	broad.mit.edu	37	20	21689905	21689905	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:21689905G>A	ENST00000398485.2	+	4	1159	c.1105G>A	c.(1105-1107)Gcc>Acc	p.A369T	PAX1_ENST00000444366.2_Missense_Mutation_p.A345T|PAX1_ENST00000460221.1_3'UTR	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	369					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CCCCGCCTGCGCCTACCCGGC	0.711000													17	22					0	0	0.034045	0	0
IGF2R	3482	broad.mit.edu	37	6	160485539	160485539	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:160485539C>T	ENST00000356956.1	+	28	4141	c.3993C>T	c.(3991-3993)ttC>ttT	p.F1331F		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1331					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CCATCTTCTTCTACTGTGACC	0.522000													21	49					0	0	0.055883	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47121403	47121403	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:47121403G>A	ENST00000290341.3	+	11	1609	c.1275G>A	c.(1273-1275)ggG>ggA	p.G425G	IGF2BP1_ENST00000431824.2_Silent_p.G286G	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	425	KH 3.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GCAAGAAGGGGCAGCACATCA	0.587000													48	55					0	0	0.048971	0	0
PPFIA2	8499	broad.mit.edu	37	12	81768424	81768424	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:81768424C>T	ENST00000550584.2	-	10	1550	c.1255G>A	c.(1255-1257)Gcc>Acc	p.A419T	PPFIA2_ENST00000552948.1_Missense_Mutation_p.A419T|PPFIA2_ENST00000549325.1_Missense_Mutation_p.A401T|PPFIA2_ENST00000443686.3_Missense_Mutation_p.A320T|PPFIA2_ENST00000333447.7_Missense_Mutation_p.A401T|PPFIA2_ENST00000407050.4_Missense_Mutation_p.A345T|PPFIA2_ENST00000548586.1_Missense_Mutation_p.A419T|PPFIA2_ENST00000550359.2_Missense_Mutation_p.A266T|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549396.1_Missense_Mutation_p.A419T	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	345										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TTGGTTAGGGCTGCAATTCTC	0.418000													45	65					0	0	0.048971	0	0
CSMD1	64478	broad.mit.edu	37	8	2876020	2876020	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:2876020C>T	ENST00000602557.1	-	53	8566	c.8011G>A	c.(8011-8013)Ggc>Agc	p.G2671S	CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000520002.1_Missense_Mutation_p.G2671S|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2670S|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000400186.3_Intron			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2671	Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTTCGCTGCCGCTCCAGAGC	0.463000													144	177					0	0	0.048971	0	0
C14orf28	122525	broad.mit.edu	37	14	45369750	45369750	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:45369750G>T	ENST00000325192.3	+	2	387	c.112G>T	c.(112-114)Ggc>Tgc	p.G38C	RP11-857B24.5_ENST00000555157.1_RNA|C14orf28_ENST00000557112.1_Missense_Mutation_p.G38C	NM_001017923.1	NP_001017923.1	Q4W4Y0	CN028_HUMAN	chromosome 14 open reading frame 28	38										endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(2)	11						TATCAAAGCTGGCCGCAAAGC	0.363000													9	25					7.03913e-09	8.78333e-09	0.013537	1	0
CEP290	80184	broad.mit.edu	37	12	88478385	88478385	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:88478385C>G	ENST00000552810.1	-	35	5025	c.4682G>C	c.(4681-4683)cGt>cCt	p.R1561P	CEP290_ENST00000309041.7_Missense_Mutation_p.R1563P|CEP290_ENST00000547691.2_Missense_Mutation_p.R621P|CEP290_ENST00000397838.3_Missense_Mutation_p.R621P	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1561					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						TTCTAGAAGACGTTGATACTT	0.299000													16	47					0	0	0.038395	0	0
KLRC2	3822	broad.mit.edu	37	12	10586496	10586496	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:10586496T>C	ENST00000381902.2	-	4	383	c.377A>G	c.(376-378)aAc>aGc	p.N126S	NKG2-E_ENST00000539033.1_Intron|KLRC2_ENST00000536833.2_Missense_Mutation_p.N67S|KLRC2_ENST00000381901.1_Missense_Mutation_p.N126S	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	126	C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						ATAACAACTGTTGGAATATGT	0.348000													65	15					0	0	0.048971	0	0
ENPEP	2028	broad.mit.edu	37	4	111470770	111470770	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:111470770G>T	ENST00000265162.5	+	16	2654	c.2312G>T	c.(2311-2313)tGg>tTg	p.W771L		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	771					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TTTGAGCAGTGGCTAAATGGG	0.403000													31	43					2.47316e-13	3.58269e-13	0.059317	1	0
MUC16	94025	broad.mit.edu	37	19	9083754	9083754	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:9083754G>T	ENST00000397910.4	-	1	8264	c.8061C>A	c.(8059-8061)acC>acA	p.T2687T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2687	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCTGACATGGTCAGGGTAG	0.473000													40	11					7.63091e-17	1.20443e-16	0.030466	1	0
DNASE2B	58511	broad.mit.edu	37	1	84878197	84878197	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:84878197T>A	ENST00000370665.3	+	5	746	c.713T>A	c.(712-714)cTc>cAc	p.L238H	DNASE2B_ENST00000370662.3_Missense_Mutation_p.L30H	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	238					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		CAAAAATTCCTCCATTTTGCA	0.483000													24	58					0	0	0.027356	0	0
PTPN13	5783	broad.mit.edu	37	4	87687592	87687592	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:87687592C>T	ENST00000436978.1	+	27	4746	c.4266C>T	c.(4264-4266)cgC>cgT	p.R1422R	PTPN13_ENST00000511467.1_Silent_p.R1422R|PTPN13_ENST00000427191.2_Silent_p.R1398R|PTPN13_ENST00000316707.6_Silent_p.R1226R|PTPN13_ENST00000411767.2_Silent_p.R1417R	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1417	PDZ 2.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TAGGTGATCGCGTCCTAGCTG	0.378000													16	31					0	0	0.033300	0	0
SPTA1	6708	broad.mit.edu	37	1	158623138	158623138	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:158623138C>A	ENST00000368148.3	-	22	3294	c.3114G>T	c.(3112-3114)gaG>gaT	p.E1038D	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1038D	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1038					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCATCGGGAACTCATCGTGGG	0.567000													18	24					3.41278e-10	4.44187e-10	0.033300	1	0
OR8H1	219469	broad.mit.edu	37	11	56058181	56058181	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:56058181C>G	ENST00000313022.2	-	1	385	c.358G>C	c.(358-360)Gat>Cat	p.D120H		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					ACGTAGCGATCATAGGCCATT	0.443000													72	11					0	0	0.048971	0	0
ADAM10	102	broad.mit.edu	37	15	58902605	58902605	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:58902605C>T	ENST00000260408.3	-	14	2359	c.1916G>A	c.(1915-1917)tGt>tAt	p.C639Y	ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Missense_Mutation_p.C338Y	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	639	Cys-rich.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		GAAAACATCACAGTAACCTCT	0.458000													29	35					0	0	0.034045	0	0
GOSR2	9570	broad.mit.edu	37	17	45017938	45017938	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:45017938C>T	ENST00000225567.4	+	7	632	c.601C>T	c.(601-603)Cag>Tag	p.Q201*	GOSR2_ENST00000439730.2_Intron|RP11-156P1.2_ENST00000571841.1_Intron	NM_054022.2	NP_473363.1	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2	0					cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			kidney(1)|large_intestine(2)|liver(1)|lung(1)|ovary(1)|skin(1)	7			BRCA - Breast invasive adenocarcinoma(9;0.102)			AGGATCCTGCCAGACAGCACA	0.567000											OREG0024493	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	43					0	0	0.030466	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913915	77913915	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:77913915C>A	ENST00000321110.1	-	2	298	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	1							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						AGTCCTCCACCATCTTTTGAG	0.458000													15	0					8.60227e-14	1.25475e-13	0.028581	1	0
PCSK6	5046	broad.mit.edu	37	15	101971606	101971606	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:101971606C>A	ENST00000348070.1	-	5	572	c.573G>T	c.(571-573)agG>agT	p.R191S	PCSK6_ENST00000344273.2_Missense_Mutation_p.R191S|PCSK6_ENST00000398181.2_Missense_Mutation_p.R191S|PCSK6_ENST00000331826.7_Missense_Mutation_p.R26S|PCSK6_ENST00000358417.3_Missense_Mutation_p.R191S|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	192	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTGTGTAGCCCCTCTTCCACG	0.517000													13	21					2.5808e-16	4.02833e-16	0.038395	1	0
DDX59	83479	broad.mit.edu	37	1	200635398	200635398	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:200635398C>A	ENST00000447706.2	-	2	622	c.471G>T	c.(469-471)gaG>gaT	p.E157D	DDX59_ENST00000367348.3_Missense_Mutation_p.E157D|DDX59_ENST00000331314.6_Missense_Mutation_p.E157D			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	157						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						GAGACTCTGGCTCAGAATCAG	0.408000													52	32					1.07234e-20	1.80001e-20	0.048971	1	0
ZNF536	9745	broad.mit.edu	37	19	31039049	31039049	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:31039049C>A	ENST00000355537.3	+	4	2670	c.2523C>A	c.(2521-2523)gcC>gcA	p.A841A		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	841					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGAGGGGGGCCTTCAAGGGTC	0.592000													26	31					1.38267e-23	2.38722e-23	0.027356	1	0
AK5	26289	broad.mit.edu	37	1	78001542	78001542	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:78001542C>A	ENST00000344720.5	+	13	2387	c.1361C>A	c.(1360-1362)cCa>cAa	p.P454Q	AK5_ENST00000478255.1_5'UTR|AK5_ENST00000354567.2_Missense_Mutation_p.P480Q	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	480					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						ATTGGAGACCCACAGTTGGTG	0.562000													4	16					0.014758	0.0153382	0.014758	1	0
NMBR	4829	broad.mit.edu	37	6	142409565	142409565	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:142409565G>T	ENST00000258042.1	-	1	371	c.231C>A	c.(229-231)gtC>gtA	p.V77V	RP11-137J7.2_ENST00000454401.1_RNA	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	77					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AGATGTTGGGGACGCTCCTCA	0.592000													6	14					2.7689e-08	3.3851e-08	0.029380	1	0
CDCA7	83879	broad.mit.edu	37	2	174230312	174230312	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:174230312C>T	ENST00000306721.3	+	7	1130	c.1027C>T	c.(1027-1029)Cgt>Tgt	p.R343C	CDCA7_ENST00000392567.2_Missense_Mutation_p.R264C|CDCA7_ENST00000347703.3_Missense_Mutation_p.R264C|CDCA7_ENST00000410019.3_Missense_Mutation_p.R222C|CDCA7_ENST00000410101.3_Missense_Mutation_p.R299C	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	264	Mediates transcriptional activity.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			GATATATAACCGTTCACTGGT	0.468000													6	16					0	0	0.021553	0	0
BAGE2	85319	broad.mit.edu	37	21	11039311	11039311	+	RNA	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:11039311T>A	ENST00000470054.1	-	0	892									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAATGTTTTCTGTCACTTCCA	0.383000													8	222					0	0	0.008291	0	0
LOC283299	283299	broad.mit.edu	37	11	7846582	7846582	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:7846582C>A	ENST00000527565.1	-	0	542																											TAACTAGTTTCATCAAGAAAA	0.348000													9	7					7.48243e-07	8.89064e-07	0.058154	1	0
CD207	50489	broad.mit.edu	37	2	71062642	71062642	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:71062642A>T	ENST00000410009.3	-	2	215	c.170T>A	c.(169-171)gTc>gAc	p.V57D		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	57					defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						CTGCAGCAGGACGGAGGCGAC	0.602000													10	14					0	0	0.010729	0	0
CDH18	1016	broad.mit.edu	37	5	19473541	19473541	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:19473541C>T	ENST00000507958.1	-	15	3157	c.2167G>A	c.(2167-2169)Gca>Aca	p.A723T	CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.A723T|CDH18_ENST00000274170.4_Missense_Mutation_p.A723T			Q13634	CAD18_HUMAN	cadherin 18, type 2	723					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCTAGGTCTGCTTCTGCCAGT	0.488000													18	156					0	0	0.038395	0	0
BLMH	642	broad.mit.edu	37	17	28614853	28614853	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:28614853C>A	ENST00000261714.6	-	4	608	c.434G>T	c.(433-435)gGc>gTc	p.G145V	BLMH_ENST00000394819.3_Missense_Mutation_p.G58V	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	145					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						ATCCCATTGGCCACCATCATT	0.428000													16	23					5.01169e-05	5.59353e-05	0.033300	1	0
OR56A4	120793	broad.mit.edu	37	11	6023495	6023495	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:6023495G>A	ENST00000330728.4	-	1	929	c.884C>T	c.(883-885)aCg>aTg	p.T295M		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAACCACACGTGCTCAAGGC	0.488000													9	29					0	0	0.058154	0	0
PTGER4	5734	broad.mit.edu	37	5	40681904	40681904	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:40681904T>A	ENST00000302472.3	+	2	1833	c.809T>A	c.(808-810)aTg>aAg	p.M270K		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	270					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GAGATCCAGATGGTCATCTTA	0.692000													17	23					0	0	0.043863	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316933	39316933	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:39316933G>T	ENST00000390661.3	-	1	50	c.11C>A	c.(10-12)tCc>tAc	p.S4Y		NM_032524.1	NP_115913.1	Q9BYR3	KRA44_HUMAN	keratin associated protein 4-4	4						keratin filament				kidney(1)|large_intestine(1)|lung(5)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GCCACAACAGGAGTTGACCAT	0.587000													53	90					5.5144e-22	9.33037e-22	0.048971	1	0
TTN	7273	broad.mit.edu	37	2	179475105	179475105	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:179475105G>T	ENST00000589042.1	-	271	51372	c.51148C>A	c.(51148-51150)Cca>Aca	p.P17050T	TTN_ENST00000460472.2_Missense_Mutation_p.P7985T|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P8110T|TTN_ENST00000342992.6_Missense_Mutation_p.P14482T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P15409T|TTN_ENST00000342175.6_Missense_Mutation_p.P8177T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15409	Ig-like 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P14482S(2)|p.P8110S(1)|p.P8177S(1)|p.P7985S(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTGCATGGTCCAGGTAGG	0.353000													18	42					1.56452e-12	2.17695e-12	0.043863	1	0
C17orf77	146723	broad.mit.edu	37	17	72588122	72588122	+	Splice_Site	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:72588122G>T	ENST00000392620.1	+	3	299		c.e3-1		C17orf77_ENST00000328023.2_Splice_Site|CD300LD_ENST00000375352.1_Intron	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77							extracellular region				breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						TGTTTCTGCAGCATCTAACAC	0.383000													33	45					1.08312e-15	1.68441e-15	0.041601	1	0
MTMR7	9108	broad.mit.edu	37	8	17228593	17228593	+	Missense_Mutation	SNP	C	C	A	rs148455057		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:17228593C>A	ENST00000180173.5	-	3	297	c.263G>T	c.(262-264)aGa>aTa	p.R88I	MTMR7_ENST00000521857.1_Missense_Mutation_p.R88I	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	88							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		GTGGCAATCTCTTTCCTGAGG	0.468000													35	46					6.02846e-25	1.05811e-24	0.059317	1	0
CSMD1	64478	broad.mit.edu	37	8	3165275	3165275	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:3165275A>T	ENST00000602557.1	-	26	4450	c.3895T>A	c.(3895-3897)Tat>Aat	p.Y1299N	CSMD1_ENST00000602723.1_Missense_Mutation_p.Y1299N|CSMD1_ENST00000520002.1_Missense_Mutation_p.Y1299N|CSMD1_ENST00000537824.1_Missense_Mutation_p.Y1298N|CSMD1_ENST00000539096.1_Missense_Mutation_p.Y1298N|CSMD1_ENST00000542608.1_Missense_Mutation_p.Y1298N|CSMD1_ENST00000400186.3_Missense_Mutation_p.Y1299N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1299	CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTGTTGTCATACGGAGCTGGA	0.463000													112	142					0	0	0.048971	0	0
NEBL	10529	broad.mit.edu	37	10	21134261	21134261	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:21134261C>A	ENST00000377122.4	-	12	1549	c.1153G>T	c.(1153-1155)Gga>Tga	p.G385*	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	385					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GATGACCTTCCTTTAATCTCC	0.328000													27	35					5.77227e-19	9.39104e-19	0.037714	1	0
ADCY1	107	broad.mit.edu	37	7	45743309	45743309	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:45743309G>T	ENST00000297323.7	+	16	2704	c.2682G>T	c.(2680-2682)ctG>ctT	p.L894L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	894					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	TGGAGTGTCTGCGGCTTCTCA	0.587000													52	91					1.75667e-42	3.24485e-42	0.048971	1	0
SNCG	6623	broad.mit.edu	37	10	88719864	88719864	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:88719864C>T	ENST00000348795.4	+	3	390	c.322C>T	c.(322-324)Cac>Tac	p.H108Y	SNCG_ENST00000483064.1_3'UTR|SNCG_ENST00000372017.3_Silent_p.V90V			O76070	SYUG_HUMAN	synuclein, gamma (breast cancer-specific protein 1)	0						microtubule organizing center|perinuclear region of cytoplasm|spindle	protein binding			endometrium(1)|skin(1)	2						ACATCGCGGTCACCTCCGGGG	0.667000													5	6					0	0	0.014758	0	0
ARGFX	503582	broad.mit.edu	37	3	121305147	121305147	+	Silent	SNP	G	G	T	rs145252171		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:121305147G>T	ENST00000334384.3	+	4	658	c.648G>T	c.(646-648)tcG>tcT	p.S216S		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	216						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		TGGTGGCCTCGGTTCCTGCTT	0.458000													55	54					2.30037e-20	3.8159e-20	0.048971	1	0
NOP16	51491	broad.mit.edu	37	5	175811104	175811104	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:175811104A>T	ENST00000510123.1	-	5	796	c.574T>A	c.(574-576)Tta>Ata	p.L192I	NOP16_ENST00000507413.1_3'UTR|NOP16_ENST00000389158.5_3'UTR	NM_001256539.1|NM_001256540.1|NM_016391.5	NP_001243468.1|NP_001243469.1|NP_057475.2	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein	0						nucleolus				central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	8						CGTGTGTGTAACCTTCTGATT	0.572000													7	4					0	0	0.047766	0	0
KCNN2	3781	broad.mit.edu	37	5	113831781	113831781	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:113831781G>T	ENST00000512097.3	+	9	2660	c.1642G>T	c.(1642-1644)Gac>Tac	p.D548Y	KCNN2_ENST00000503706.1_Missense_Mutation_p.D200Y|RP11-492A10.1_ENST00000514115.1_RNA|KCNN2_ENST00000264773.3_Missense_Mutation_p.D548Y			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	548						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GGAGAGCTACGACAAGCACGT	0.552000													46	79					8.86878e-18	1.41566e-17	0.048971	1	0
OOEP	441161	broad.mit.edu	37	6	74078998	74078998	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:74078998G>A	ENST00000370363.1	-	3	628	c.136C>T	c.(136-138)Cgt>Tgt	p.R46C	OOEP_ENST00000370359.5_Missense_Mutation_p.R101C			A6NGQ2	OOEP_HUMAN	oocyte expressed protein	101						cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						TTCTGTACACGGGGCCGCCCG	0.557000													14	8					0	0	0.024245	0	0
IFI35	3430	broad.mit.edu	37	17	41158983	41158983	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:41158983G>A	ENST00000415816.2	+	1	242	c.19G>A	c.(19-21)Gcc>Acc	p.A7T	IFI35_ENST00000536969.1_3'UTR|IFI35_ENST00000438323.2_Missense_Mutation_p.A7T	NM_005533.4	NP_005524.2	P80217	IN35_HUMAN	interferon-induced protein 35	7	Leucine-zipper.				response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		CCCACTGGATGCCGTAAGTGA	0.557000													51	60					0	0	0.048971	0	0
ZUFSP	221302	broad.mit.edu	37	6	116972826	116972826	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:116972826C>A	ENST00000368576.3	-	7	1468	c.1225G>T	c.(1225-1227)Ggg>Tgg	p.G409W		NM_145062.2	NP_659499.2	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	409						intracellular	zinc ion binding			NS(1)|endometrium(2)|kidney(6)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		TGAGAGGCCCCCTGAGGATCA	0.398000													11	33					4.36969e-10	5.66987e-10	0.016723	1	0
OSGEP	55644	broad.mit.edu	37	14	20922834	20922834	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:20922834C>T	ENST00000206542.4	-	1	430	c.9G>A	c.(7-9)gcG>gcA	p.A3A	OSGEP_ENST00000556252.1_5'UTR	NM_017807.3	NP_060277.1	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	3					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(4)|stomach(1)	11	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		AACCCAGCACCGCCGGCATGG	0.652000													49	25					0	0	0.048971	0	0
BAZ1B	9031	broad.mit.edu	37	7	72891240	72891240	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:72891240G>C	ENST00000339594.4	-	7	2889	c.2551C>G	c.(2551-2553)Caa>Gaa	p.Q851E	BAZ1B_ENST00000404251.1_Missense_Mutation_p.Q851E	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	851					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTCTTAGCTTGAATGGCAAGC	0.393000													77	28					0	0	0.048971	0	0
SNHG14	104472715	broad.mit.edu	37	15	25442626	25442626	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:25442626C>A	ENST00000424208.1	+	0	1602				SNHG14_ENST00000424333.1_RNA|SNHG14_ENST00000456576.1_RNA	NR_003305.1																						AGCTCAGGCCCTTCCTGATGC	0.597000													9	5					1.12685e-05	1.28479e-05	0.047766	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16824567	16824567	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:16824567C>A	ENST00000355661.3	-	15	2119	c.2109G>T	c.(2107-2109)agG>agT	p.R703S	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.R703S|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.R703S			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	703					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						CCTGGAGGACCCTGTCTTGTT	0.463000													43	21					1.46156e-29	2.6086e-29	0.048971	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140710332	140710332	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:140710332G>T	ENST00000517417.1	+	1	81	c.81G>T	c.(79-81)ggG>ggT	p.G27G	PCDHGA1_ENST00000378105.3_Silent_p.G27G	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGCTGGGGCTGGGAATA	0.532000													41	78					6.57855e-14	9.69591e-14	0.036044	1	0
CSTF3	1479	broad.mit.edu	37	11	33129503	33129503	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:33129503C>A	ENST00000323959.4	-	5	441	c.302G>T	c.(301-303)tGg>tTg	p.W101L	CSTF3_ENST00000524827.1_Missense_Mutation_p.W133L	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	101					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ATAACACTTCCATAAATCAAT	0.338000													10	28					4.68919e-08	5.65107e-08	0.008291	1	0
LAMB2	3913	broad.mit.edu	37	3	49162900	49162900	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:49162900C>A	ENST00000418109.1	-	20	2670	c.2506G>T	c.(2506-2508)Gag>Tag	p.E836*	LAMB2_ENST00000464891.1_5'UTR|LAMB2_ENST00000305544.4_Nonsense_Mutation_p.E836*	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	836	Laminin EGF-like 7.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGTGCCCCCTCGTGGCTGCAC	0.642000													4	3					0.00024832	0.00027072	0.009096	1	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720749	31720749	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:31720749C>A	ENST00000334160.4	-	1	175	c.176G>T	c.(175-177)gGa>gTa	p.G59V		NM_181624.1	NP_853655.1	A1A580	KR231_HUMAN	keratin associated protein 23-1	59						intermediate filament				large_intestine(1)|lung(4)|prostate(1)	6						CAGCAAGTCTCCTGAAAGCCC	0.612000													27	39					7.26314e-15	1.10119e-14	0.034045	1	0
PDE3A	5139	broad.mit.edu	37	12	20523096	20523096	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:20523096G>C	ENST00000359062.3	+	1	918	c.878G>C	c.(877-879)aGc>aCc	p.S293T	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	293					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGGCGGTCCAGCTCCGTCGTG	0.627000													7	5					0	0	0.038147	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656261	40656261	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:40656261G>T	ENST00000406785.1	-	2	1349	c.1160C>A	c.(1159-1161)gCa>gAa	p.A387E	SLC8A1_ENST00000542024.1_Missense_Mutation_p.A387E|SLC8A1_ENST00000408028.2_Missense_Mutation_p.A387E|SLC8A1_ENST00000405269.1_Missense_Mutation_p.A387E|SLC8A1_ENST00000332839.4_Missense_Mutation_p.A387E|SLC8A1_ENST00000542756.1_Missense_Mutation_p.A387E|SLC8A1_ENST00000403092.1_Missense_Mutation_p.A387E|SLC8A1_ENST00000406391.2_Missense_Mutation_p.A387E|SLC8A1_ENST00000405901.3_Missense_Mutation_p.A387E|SLC8A1_ENST00000402441.1_Missense_Mutation_p.A387E			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	387					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGCCTTCCTTGCTTGGTCAGC	0.453000													16	29					4.7546e-09	5.96795e-09	0.028581	1	0
GPIHBP1	338328	broad.mit.edu	37	8	144297260	144297260	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:144297260G>T	ENST00000330824.2	+	4	497	c.422G>T	c.(421-423)tGg>tTg	p.W141L		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	141	UPAR/Ly6.				cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTCCCACCCTGGCAAAGCTCC	0.667000													7	0					1.76689e-08	2.16637e-08	0.058154	1	0
PCDHB11	56125	broad.mit.edu	37	5	140580573	140580573	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:140580573T>C	ENST00000354757.3	+	1	1226	c.1226T>C	c.(1225-1227)cTg>cCg	p.L409P	PCDHB11_ENST00000536699.1_Missense_Mutation_p.L44P	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		409	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAGACCACTGGACAGAGAG	0.488000													52	68					0	0	0.048971	0	0
CDH9	1007	broad.mit.edu	37	5	26902619	26902619	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:26902619C>T	ENST00000231021.4	-	7	1391	c.1219G>A	c.(1219-1221)Gca>Aca	p.A407T		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	407	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GGATCGTATGCTGTAACCTGT	0.333000													22	88					0	0	0.055883	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233364	125233364	+	RNA	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:125233364T>A	ENST00000439075.1	-	0	1381					NR_026876.1																						CTATATTTGCTATTTCACTGA	0.368000													11	14					0	0	0.010729	0	0
GPR98	84059	broad.mit.edu	37	5	89953780	89953780	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:89953780G>T	ENST00000405460.2	+	21	4533	c.4437G>T	c.(4435-4437)ctG>ctT	p.L1479L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1479					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTACAGGTCTGATGCAGGATG	0.413000													62	81					5.10652e-33	9.23102e-33	0.048971	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995704	57995704	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:57995704G>T	ENST00000316770.2	-	1	686	c.644C>A	c.(643-645)cCc>cAc	p.P215H		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				GAGCAGGAAGGGGATGGTCAG	0.637000													26	8					1.80694e-10	2.38855e-10	0.041601	1	0
ZNF236	7776	broad.mit.edu	37	18	74640002	74640002	+	Missense_Mutation	SNP	G	G	T	rs76679748	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:74640002G>T	ENST00000253159.8	+	25	4726	c.4528G>T	c.(4528-4530)Gct>Tct	p.A1510S	ZNF236_ENST00000320610.9_Missense_Mutation_p.A1512S	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1510					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GGCACAGGCCGCTGGGCCCAC	0.542000													23	32					3.1745e-13	4.5519e-13	0.037714	1	0
SCN11A	11280	broad.mit.edu	37	3	38926863	38926863	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:38926863A>G	ENST00000302328.3	-	17	3178	c.2980T>C	c.(2980-2982)Tgt>Cgt	p.C994R	SCN11A_ENST00000456224.3_Missense_Mutation_p.C956R|SCN11A_ENST00000444237.2_Missense_Mutation_p.C994R|SCN11A_ENST00000450244.1_Missense_Mutation_p.C994R	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	994					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATGGTGCTACATTCTGATAGT	0.428000													41	51					0	0	0.036044	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128505565	128505565	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:128505565A>G	ENST00000492758.1	+	3	378	c.377A>G	c.(376-378)tAt>tGt	p.Y126C	ATP6V1F_ENST00000249289.4_Missense_Mutation_p.Y98C	NM_001198909.1	NP_001185838.1	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	98					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			lung(1)|ovary(1)|prostate(1)	3						GAGCACCCATATGACGCCGCC	0.632000													6	1					0	0	0.021553	0	0
DPP6	1804	broad.mit.edu	37	7	154379486	154379486	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:154379486C>A	ENST00000406326.1	+	6	1157	c.754C>A	c.(754-756)Ctt>Att	p.L252I	DPP6_ENST00000427557.1_Intron|DPP6_ENST00000404039.1_Intron|DPP6_ENST00000332007.3_Intron|DPP6_ENST00000377770.3_Intron			P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	363					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			caccatgtctcTTCCTCTTCA	0.478000													6	17					5.4927e-09	6.874e-09	0.047766	1	0
THSD7A	221981	broad.mit.edu	37	7	11452302	11452302	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:11452302G>T	ENST00000423059.3	-	18	3914	c.3663C>A	c.(3661-3663)caC>caA	p.H1221Q	AC004538.3_ENST00000445839.1_RNA|AC004160.4_ENST00000425837.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1221	TSP type-1 12.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TATAATCATAGTGGTAGCAGT	0.423000										HNSCC(18;0.044)			32	22					8.4185e-14	1.23219e-13	0.050027	1	0
UBR4	23352	broad.mit.edu	37	1	19518753	19518753	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:19518753G>A	ENST00000375267.2	-	11	1326	c.1323C>T	c.(1321-1323)gcC>gcT	p.A441A	UBR4_ENST00000375226.2_Silent_p.A441A|UBR4_ENST00000375217.2_Silent_p.A441A|UBR4_ENST00000375254.3_Silent_p.A441A			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	441					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGACTCGGAGGGCAGCCAGTG	0.493000													6	45					0	0	0.021553	0	0
TGM7	116179	broad.mit.edu	37	15	43571883	43571883	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:43571883C>A	ENST00000452443.2	-	10	1622	c.1618G>T	c.(1618-1620)Ggt>Tgt	p.G540C		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	540					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGGTACCACCCCCATGCAGC	0.642000													83	57					2.36867e-37	4.35629e-37	0.048971	1	0
NRXN3	9369	broad.mit.edu	37	14	79432671	79432671	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:79432671A>G	ENST00000554719.1	+	9	2071	c.1580A>G	c.(1579-1581)aAg>aGg	p.K527R	NRXN3_ENST00000335750.5_Missense_Mutation_p.K527R	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	118					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTCCAGTTCAAGACCACCTCA	0.493000													88	58					0	0	0.048971	0	0
COL17A1	1308	broad.mit.edu	37	10	105817909	105817909	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:105817909G>C	ENST00000353479.5	-	16	1552	c.1262C>G	c.(1261-1263)aCt>aGt	p.T421S	COL17A1_ENST00000369733.3_Missense_Mutation_p.T421S	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	421	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCCACCTGCAGTGGTGGTCTT	0.542000													17	19					0	0	0.033300	0	0
DLG4	1742	broad.mit.edu	37	17	7097798	7097798	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:7097798C>T	ENST00000399510.2	-	14	2299	c.1447G>A	c.(1447-1449)Gac>Aac	p.D483N	DLG4_ENST00000399506.2_Missense_Mutation_p.D440N|DLG4_ENST00000302955.6_Missense_Mutation_p.D437N	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	440	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TTGGTCTTGTCGTAATCAAAC	0.607000													9	0					0	0	0.058154	0	0
NPRL2	10641	broad.mit.edu	37	3	50387112	50387112	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:50387112T>G	ENST00000232501.3	-	3	761	c.323A>C	c.(322-324)tAt>tCt	p.Y108S		NM_006545.4	NP_006536.3	Q8WTW4	NPRL2_HUMAN	nitrogen permease regulator-like 2 (S. cerevisiae)	108	Interaction with PDPK1.				negative regulation of kinase activity		protein binding|protein kinase activity	p.Y108S(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	11						TGTGGTCAGATAGCCAGCCAG	0.557000													9	6					0	0	0.010729	0	0
FLJ26245	400533	broad.mit.edu	37	16	34981003	34981003	+	RNA	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:34981003G>T	ENST00000516136.1	+	0	110																											tggggagatcggggctggagg	0.622000													11	8					0.010729	0.0112615	0.010729	1	0
CPA3	1359	broad.mit.edu	37	3	148596236	148596236	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:148596236T>G	ENST00000296046.3	+	4	330	c.278T>G	c.(277-279)aTt>aGt	p.I93S	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	93					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			AGAATCTTGATTCATGATCTA	0.353000													38	36					0	0	0.042209	0	0
TRHDE	29953	broad.mit.edu	37	12	72680485	72680485	+	Silent	SNP	G	G	T	rs143921572	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:72680485G>T	ENST00000261180.4	+	2	900	c.804G>T	c.(802-804)tcG>tcT	p.S268S		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	268					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CTCAGTTTTCGCCTACACATG	0.358000													40	35					4.67007e-22	7.93348e-22	0.033182	1	0
BIN2	51411	broad.mit.edu	37	12	51693012	51693012	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:51693012C>A	ENST00000267012.4	-	7	638	c.577G>T	c.(577-579)Gag>Tag	p.E193*	BIN2_ENST00000604560.1_Nonsense_Mutation_p.E166*|BIN2_ENST00000544402.1_Nonsense_Mutation_p.E167*|BIN2_ENST00000452142.2_Nonsense_Mutation_p.E161*	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	193	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						GGCAGCTCCTCTAGTAGTTCT	0.418000													15	28					2.62699e-14	3.91273e-14	0.024245	1	0
CHRNA6	8973	broad.mit.edu	37	8	42611340	42611340	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:42611340C>T	ENST00000276410.2	-	5	1357	c.1002G>A	c.(1000-1002)acG>acA	p.T334T	CHRNA6_ENST00000534622.1_Silent_p.T319T	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	334						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.T334T(1)		endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCATTGTGTGCGTGGTTGGGG	0.552000													36	57					0	0	0.019004	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76555966	76555966	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:76555966T>A	ENST00000307431.8	+	18	2949	c.2564T>A	c.(2563-2565)gTg>gAg	p.V855E	CNTNAP4_ENST00000476707.1_Missense_Mutation_p.V859E|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.V807E|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.V783E	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	856	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TCATTTGATGTGGGGAATGGG	0.463000													132	244					0	0	0.048971	0	0
OR13C8	138802	broad.mit.edu	37	9	107332204	107332204	+	Silent	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:107332204T>C	ENST00000335040.1	+	1	756	c.756T>C	c.(754-756)taT>taC	p.Y252Y		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						TTATATTCTATGGAACCATCT	0.438000													21	39					0	0	0.062417	0	0
IL5RA	3568	broad.mit.edu	37	3	3139640	3139640	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:3139640C>T	ENST00000446632.2	-	7	1197	c.623G>A	c.(622-624)cGt>cAt	p.R208H	IL5RA_ENST00000311981.8_Missense_Mutation_p.R208H|IL5RA_ENST00000383846.1_Missense_Mutation_p.R208H|IL5RA_ENST00000430514.2_Missense_Mutation_p.R208H|IL5RA_ENST00000456302.1_Missense_Mutation_p.R208H|IL5RA_ENST00000438560.1_Missense_Mutation_p.R208H|IL5RA_ENST00000418488.2_Missense_Mutation_p.R208H|IL5RA_ENST00000256452.3_Missense_Mutation_p.R208H|IL5RA_ENST00000445864.2_Intron	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	208					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AAGCCAGTCACGCCCTTTGCT	0.502000													20	19					0	0	0.016522	0	0
INPP5B	3633	broad.mit.edu	37	1	38353938	38353938	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:38353938C>A	ENST00000373023.2	-	10	1209	c.1116G>T	c.(1114-1116)caG>caT	p.Q372H	INPP5B_ENST00000467066.1_5'UTR|INPP5B_ENST00000458109.2_Missense_Mutation_p.Q55H|INPP5B_ENST00000373027.1_Missense_Mutation_p.Q128H|INPP5B_ENST00000373026.1_Missense_Mutation_p.Q372H|INPP5B_ENST00000373024.3_Missense_Mutation_p.Q292H	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	372					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CATCTGGGGCCTGGATACCAT	0.488000													41	51					7.90463e-13	1.11828e-12	0.048971	1	0
OR2M4	26245	broad.mit.edu	37	1	248402846	248402846	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:248402846A>T	ENST00000306687.1	+	1	616	c.616A>T	c.(616-618)Atg>Ttg	p.M206L		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTGTGTGGTAATGCTAATCTT	0.438000													15	70					0	0	0.020292	0	0
ATP1B1	481	broad.mit.edu	37	1	169094246	169094246	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:169094246G>T	ENST00000367816.1	+	4	880	c.351G>T	c.(349-351)caG>caT	p.Q117H	ATP1B1_ENST00000367813.3_Missense_Mutation_p.Q109H|ATP1B1_ENST00000367815.3_Missense_Mutation_p.Q117H|ATP1B1_ENST00000499679.3_Missense_Mutation_p.Q61H|ATP1B1_ENST00000494797.1_3'UTR			P05026	AT1B1_HUMAN	ATPase, Na+/K+ transporting, beta 1 polypeptide	117					ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	14	all_hematologic(923;0.208)					ATTCAGCCCAGAGGGATGACA	0.388000													35	34					4.34086e-07	5.21643e-07	0.023175	1	0
OR10P1	121130	broad.mit.edu	37	12	56031458	56031458	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:56031458C>G	ENST00000309675.2	+	1	815	c.783C>G	c.(781-783)atC>atG	p.I261M		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I261I(1)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TCACCTACATCCGGCCGCAGG	0.582000													56	52					0	0	0.048971	0	0
DLG5	9231	broad.mit.edu	37	10	79565530	79565530	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:79565530C>A	ENST00000372391.2	-	27	5062	c.5057G>T	c.(5056-5058)cGg>cTg	p.R1686L	DLG5_ENST00000372388.2_Missense_Mutation_p.R1346L|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1686					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AAAAAAGGACCGGCGTGCAGC	0.547000													35	34					3.03874e-20	5.02104e-20	0.059317	1	0
USP35	57558	broad.mit.edu	37	11	77907354	77907354	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:77907354G>T	ENST00000529308.1	+	2	324	c.63G>T	c.(61-63)ctG>ctT	p.L21L	USP35_ENST00000530535.1_Intron|USP35_ENST00000530267.1_Intron	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	21					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			AGCAGGGGCTGGTTCGGCGCG	0.716000													10	2					4.68919e-08	5.65107e-08	0.008291	1	0
BDP1	55814	broad.mit.edu	37	5	70837343	70837343	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:70837343G>C	ENST00000358731.4	+	29	6348	c.6085G>C	c.(6085-6087)Gat>Cat	p.D2029H	BDP1_ENST00000380675.2_Missense_Mutation_p.D165H	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2029					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.D2029H(1)		NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTCTAGCCTAGATAATGTAAA	0.308000													23	25					0	0	0.018920	0	0
SYT16	83851	broad.mit.edu	37	14	62542009	62542009	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:62542009G>A	ENST00000430451.2	+	3	1090	c.893G>A	c.(892-894)cGc>cAc	p.R298H	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_Missense_Mutation_p.R298H	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	298										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		AGCCTCAGGCGCCAATCCACA	0.547000													4	150					0	0	0.009096	0	0
CEP192	55125	broad.mit.edu	37	18	13040877	13040877	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:13040877G>A	ENST00000506447.1	+	14	1938	c.1858G>A	c.(1858-1860)Gcc>Acc	p.A620T	CEP192_ENST00000325971.8_Missense_Mutation_p.A24T|CEP192_ENST00000430049.2_Missense_Mutation_p.A145T	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	215										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						AGAACCTATTGCCTTAATAAG	0.318000													47	66					0	0	0.048971	0	0
ANO1	55107	broad.mit.edu	37	11	70028779	70028779	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:70028779G>C	ENST00000355303.5	+	24	2880	c.2575G>C	c.(2575-2577)Gtg>Ctg	p.V859L	ANO1_ENST00000530676.1_Missense_Mutation_p.V713L|ANO1_ENST00000531349.1_Missense_Mutation_p.V568L|ANO1_ENST00000398543.2_Missense_Mutation_p.V713L|ANO1_ENST00000538023.1_Missense_Mutation_p.V859L|ANO1_ENST00000525494.1_3'UTR	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	859					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						GGGCTACGAGGTGCAGATCTG	0.582000													13	14					0	0	0.016723	0	0
GRIK2	2898	broad.mit.edu	37	6	102483249	102483249	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:102483249G>T	ENST00000369138.1	+	14	2609	c.2119G>T	c.(2119-2121)Gcc>Tcc	p.A707S	GRIK2_ENST00000421544.1_Missense_Mutation_p.A707S|GRIK2_ENST00000369137.3_Missense_Mutation_p.A631S|GRIK2_ENST00000318991.6_Missense_Mutation_p.A707S|GRIK2_ENST00000413795.1_Missense_Mutation_p.A707S|GRIK2_ENST00000369134.4_Missense_Mutation_p.A658S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	707					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CAAAATGTGGGCCTTTATGAG	0.388000													26	41					4.26978e-12	5.88311e-12	0.018920	1	0
GRM7	2917	broad.mit.edu	37	3	6903353	6903353	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:6903353C>A	ENST00000486284.1	+	1	552	c.278C>A	c.(277-279)cCc>cAc	p.P93H	GRM7_ENST00000402647.2_Missense_Mutation_p.P93H|GRM7_ENST00000403881.1_Missense_Mutation_p.P93H|GRM7_ENST00000389336.4_Missense_Mutation_p.P93H|GRM7_ENST00000357716.4_Missense_Mutation_p.P93H	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	93					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AACAGTGATCCCAACCTACTG	0.607000													12	15					3.07112e-06	3.57874e-06	0.010729	1	0
TRAPPC10	7109	broad.mit.edu	37	21	45509756	45509756	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:45509756G>A	ENST00000291574.4	+	18	2987	c.2812G>A	c.(2812-2814)Gca>Aca	p.A938T	TRAPPC10_ENST00000483973.1_3'UTR	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	938					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						CACAGTCATCGCACTGACCTT	0.602000													3	18					0	0	0.004672	0	0
FMO6P	388714	broad.mit.edu	37	1	171121269	171121269	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:171121269G>T	ENST00000236166.3	+	6	1158	c.1048G>T	c.(1048-1050)Gtt>Ttt	p.V350F																								AAACAATGAGGTTACCTTGTT	0.478000													12	18					4.3838e-07	5.25311e-07	0.016723	1	0
MT-ND5	4540	broad.mit.edu	37	MT	13412	13412	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrM:13412T>C	ENST00000361567.2	+	1	1076	c.1076T>C	c.(1075-1077)aTa>aCa	p.I359T				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	359					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TATTCGAAAAATAGGAGGACT	0.443000													234	13					0	0	0.048971	0	0
PAPOLA	10914	broad.mit.edu	37	14	97003388	97003388	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:97003388A>T	ENST00000216277.8	+	12	1326	c.1106A>T	c.(1105-1107)cAa>cTa	p.Q369L	PAPOLA_ENST00000392990.2_Missense_Mutation_p.Q369L	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	369					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AACTTCTTTCAAAAGTACAAG	0.338000													4	23					0	0	0.009096	0	0
EXOC6	54536	broad.mit.edu	37	10	94688135	94688135	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:94688135A>T	ENST00000371552.4	+	9	942	c.913A>T	c.(913-915)Aga>Tga	p.R305*	EXOC6_ENST00000371547.4_Nonsense_Mutation_p.R326*|EXOC6_ENST00000260762.6_Nonsense_Mutation_p.R310*|EXOC6_ENST00000443748.2_Nonsense_Mutation_p.R287*	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	310					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TCGAAAACAAAGAAAGAAACA	0.343000													33	41					0	0	0.064281	0	0
TPSB2	64499	broad.mit.edu	37	16	1278579	1278579	+	RNA	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:1278579T>A	ENST00000430512.2	-	0	947				TPSB2_ENST00000445910.1_RNA|TPSB2_ENST00000339687.6_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				GCCACCTGGGTAGGAAGCAGT	0.627000													3	0					0	0	0.014758	0	0
TMX3	54495	broad.mit.edu	37	18	66378620	66378620	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:66378620T>A	ENST00000299608.2	-	3	438	c.122A>T	c.(121-123)gAt>gTt	p.D41V	TMX3_ENST00000562706.1_Missense_Mutation_p.D41V|TMX3_ENST00000443099.2_Missense_Mutation_p.D41V	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	41	Thioredoxin.				cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						CCAAATGTCATCATTTCGATT	0.289000													18	19					0	0	0.062417	0	0
UBBP4	23666	broad.mit.edu	37	17	21731111	21731111	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:21731111A>T	ENST00000584755.1	+	2	810	c.413A>T	c.(412-414)cAg>cTg	p.Q138L	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.Q138L																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TACAACATCCAGAAAGAGTCG	0.552000													39	12					0	0	0.039052	0	0
IRGC	56269	broad.mit.edu	37	19	44223594	44223594	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:44223594T>A	ENST00000244314.5	+	2	1083	c.884T>A	c.(883-885)aTc>aAc	p.I295N		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	295						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				GCGTTGCTCATCCACTCACTG	0.647000													8	18					0	0	0.024245	0	0
BIRC6	57448	broad.mit.edu	37	2	32730166	32730166	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:32730166C>T	ENST00000421745.2	+	50	9728	c.9594C>T	c.(9592-9594)tcC>tcT	p.S3198S		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3198					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CTGCTTGGTCCTACATCTTTC	0.512000													5	20					0	0	0.021553	0	0
RFT1	91869	broad.mit.edu	37	3	53156497	53156497	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:53156497G>A	ENST00000296292.3	-	4	410	c.349C>T	c.(349-351)Cct>Tct	p.P117S	RFT1_ENST00000394738.3_Missense_Mutation_p.P78S	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	117					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GCATAGTGAGGGACAACATTA	0.502000													18	38					0	0	0.043863	0	0
ROBO1	6091	broad.mit.edu	37	3	78763601	78763601	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:78763601C>G	ENST00000436010.2	-	6	1871	c.874G>C	c.(874-876)Gtt>Ctt	p.V292L	ROBO1_ENST00000464233.1_Missense_Mutation_p.V331L|ROBO1_ENST00000467549.1_Missense_Mutation_p.V292L|ROBO1_ENST00000495273.1_Missense_Mutation_p.V292L			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	331	Ig-like C2-type 3.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding	p.V308L(2)		breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTTTCTGCAACACAAGTGTAT	0.403000													19	46					0	0	0.027356	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29417342	29417342	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:29417342G>T	ENST00000378993.1	+	5	1293	c.620G>T	c.(619-621)aGa>aTa	p.R207I	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.R207I	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	207	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity	p.R207I(2)		biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AGAGAAGTCAGAGAAGATGAC	0.338000													36	1					1.60099e-16	2.50821e-16	0.021022	1	0
SOX14	8403	broad.mit.edu	37	3	137483968	137483968	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:137483968C>T	ENST00000306087.1	+	1	390	c.342C>T	c.(340-342)gcC>gcT	p.A114A		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	114					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						CCGTGGGGGCCTCCGACGGCC	0.697000													16	14					0	0	0.018920	0	0
COL11A1	1301	broad.mit.edu	37	1	103488444	103488444	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:103488444C>G	ENST00000358392.2	-	8	1452	c.1135G>C	c.(1135-1137)Ggc>Cgc	p.G379R	COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000353414.4_Missense_Mutation_p.G328R|COL11A1_ENST00000370096.3_Missense_Mutation_p.G367R	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	367	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GAATCCCTGCCGTCTATTTCT	0.343000													6	16					0	0	0.021553	0	0
KCNA5	3741	broad.mit.edu	37	12	5154211	5154211	+	Missense_Mutation	SNP	G	G	A	rs148708451	byFrequency	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:5154211G>A	ENST00000252321.3	+	1	1127	c.898G>A	c.(898-900)Ggc>Agc	p.G300S		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	300			G -> S (in a breast cancer sample; somatic mutation).			Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.G300S(2)		NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TGGGGCCAACGGCAGCGGGGT	0.706000													15	1					0	0	0.033300	0	0
DENND2A	27147	broad.mit.edu	37	7	140287451	140287451	+	Splice_Site	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:140287451A>T	ENST00000275884.6	-	3	1541		c.e3+1		DENND2A_ENST00000492720.1_Splice_Site|DENND2A_ENST00000496613.1_Splice_Site|DENND2A_ENST00000537639.1_Splice_Site			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A											breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					GTGGCTTCTTACCTAGAATGT	0.547000													27	35					0	0	0.027356	0	0
CTNND2	1501	broad.mit.edu	37	5	11346664	11346664	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:11346664G>A	ENST00000304623.8	-	9	1637	c.1448C>T	c.(1447-1449)gCg>gTg	p.A483V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.A483V|CTNND2_ENST00000503622.1_Missense_Mutation_p.A146V|CTNND2_ENST00000458100.2_Missense_Mutation_p.A50V|CTNND2_ENST00000511377.1_Missense_Mutation_p.A392V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	483					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAAGGTGGCCGCGGCGGCATT	0.632000													8	35					0	0	0.038147	0	0
DOCK4	9732	broad.mit.edu	37	7	111398697	111398697	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:111398697T>C	ENST00000428084.1	-	41	4584	c.4312A>G	c.(4312-4314)Aaa>Gaa	p.K1438E	DOCK4_ENST00000437633.1_Missense_Mutation_p.K1429E|DOCK4_ENST00000494651.2_Missense_Mutation_p.K312E			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1429	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TCATTCTCTTTATCTTTTGTG	0.428000													23	18					0	0	0.021523	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149210434	149210434	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:149210434G>T	ENST00000309241.5	+	4	602	c.570G>T	c.(568-570)cgG>cgT	p.R190R	PPARGC1B_ENST00000403750.1_Intron|PPARGC1B_ENST00000360453.4_Intron|PPARGC1B_ENST00000394320.3_Silent_p.R190R	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	190					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AAAGTCAACGGCCTTGTGTTA	0.552000													20	28					5.35356e-11	7.25819e-11	0.016522	1	0
LONP2	83752	broad.mit.edu	37	16	48330040	48330040	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:48330040G>T	ENST00000285737.4	+	9	1591	c.1498G>T	c.(1498-1500)Gcc>Tcc	p.A500S	LONP2_ENST00000535754.1_Missense_Mutation_p.A456S	NM_031490.2	NP_113678.2	Q86WA8	LONP2_HUMAN	lon peptidase 2, peroxisomal	500					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CATTCCAGCTGCCTTGTTGGA	0.378000													57	59					2.31391e-43	4.29291e-43	0.048971	1	0
ANK1	286	broad.mit.edu	37	8	41554090	41554090	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:41554090G>T	ENST00000396942.1	-	26	2834	c.2751C>A	c.(2749-2751)ttC>ttA	p.F917L	ANK1_ENST00000352337.4_Missense_Mutation_p.F917L|ANK1_ENST00000347528.4_Missense_Mutation_p.F917L|ANK1_ENST00000379758.2_Missense_Mutation_p.F917L|ANK1_ENST00000265709.8_Missense_Mutation_p.F958L|ANK1_ENST00000289734.7_Missense_Mutation_p.F917L|ANK1_ENST00000396945.1_Missense_Mutation_p.F917L			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	917	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGTCAACCATGAAGCTCACCA	0.652000													10	8					2.17888e-05	2.46435e-05	0.058154	1	0
OR14C36	127066	broad.mit.edu	37	1	248512712	248512712	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:248512712C>A	ENST00000317861.1	+	1	636	c.636C>A	c.(634-636)atC>atA	p.I212I		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TCATCTTTATCATCAGGTCTT	0.512000													30	53					2.08457e-15	3.19483e-15	0.045705	1	0
CSMD1	64478	broad.mit.edu	37	8	2808759	2808759	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:2808759C>A	ENST00000602557.1	-	67	10636	c.10081G>T	c.(10081-10083)Ggg>Tgg	p.G3361W	CSMD1_ENST00000602723.1_Missense_Mutation_p.G3184W|CSMD1_ENST00000520002.1_Missense_Mutation_p.G3361W|CSMD1_ENST00000537824.1_Missense_Mutation_p.G3360W|CSMD1_ENST00000542608.1_Missense_Mutation_p.G3183W|CSMD1_ENST00000400186.3_Missense_Mutation_p.G3184W			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3361						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCATAATACCCCTTCCACAGT	0.438000													10	11					0.000442599	0.000478822	0.058154	1	0
PDE11A	50940	broad.mit.edu	37	2	178762914	178762914	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:178762914C>A	ENST00000286063.5	-	4	1490	c.1173G>T	c.(1171-1173)gaG>gaT	p.E391D	PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Missense_Mutation_p.E33D|PDE11A_ENST00000409504.1_Missense_Mutation_p.E33D|PDE11A_ENST00000358450.4_Missense_Mutation_p.E141D	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	391					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CATTAACCACCTCTAGCAAAG	0.348000									Primary Pigmented Nodular Adrenocortical Disease, Familial				44	21					6.5261e-18	1.04566e-17	0.033182	1	0
BCORL1	63035	broad.mit.edu	37	X	129148380	129148380	+	Silent	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:129148380C>G	ENST00000540052.1	+	3	1676	c.1632C>G	c.(1630-1632)gtC>gtG	p.V544V	BCORL1_ENST00000359304.2_Silent_p.V544V|BCORL1_ENST00000218147.7_Silent_p.V544V|BCORL1_ENST00000303743.5_Silent_p.V544V	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	544	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CCGATGGGGTCCCTGGGCCTT	0.617000													28	56					0	0	0.064281	0	0
EPHA5	2044	broad.mit.edu	37	4	66189926	66189926	+	Missense_Mutation	SNP	C	C	T	rs145811811		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:66189926C>T	ENST00000273854.3	-	18	3620	c.3020G>A	c.(3019-3021)cGg>cAg	p.R1007Q	EPHA5_ENST00000354839.4_Missense_Mutation_p.R985Q|EPHA5_ENST00000432638.2_Missense_Mutation_p.R844Q	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	1007	SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.R1007L(1)|p.R1007Q(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CACTCCAAGCCGTCTCAAATC	0.433000										TSP Lung(17;0.13)			23	23					0	0	0.014323	0	0
SRCAP	10847	broad.mit.edu	37	16	30722385	30722385	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:30722385G>T	ENST00000262518.4	+	10	1679	c.1294G>T	c.(1294-1296)Gag>Tag	p.E432*	SRCAP_ENST00000395059.2_Nonsense_Mutation_p.E432*|SRCAP_ENST00000344771.4_Nonsense_Mutation_p.E432*	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	432	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCATGCCATGGAGCTGAGCGA	0.468000													10	16					4.68919e-08	5.65107e-08	0.008291	1	0
CRHBP	1393	broad.mit.edu	37	5	76259266	76259266	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:76259266C>T	ENST00000274368.4	+	6	1214	c.792C>T	c.(790-792)tgC>tgT	p.C264C	CRHBP_ENST00000514258.1_3'UTR	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	264					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		CTGATCTCTGCTACCCCTTTC	0.443000													8	156					0	0	0.047766	0	0
LRFN5	145581	broad.mit.edu	37	14	42368154	42368154	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:42368154G>T	ENST00000298119.4	+	5	3322	c.2133G>T	c.(2131-2133)caG>caT	p.Q711H	LRFN5_ENST00000554171.1_3'UTR|LRFN5_ENST00000554120.1_Intron	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	711						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGATTGTCCAGGAAACACAGG	0.279000										HNSCC(30;0.082)			13	50					7.93312e-07	9.34738e-07	0.020292	1	0
VWC2L	402117	broad.mit.edu	37	2	215301440	215301440	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:215301440C>A	ENST00000312504.5	+	3	1280	c.478C>A	c.(478-480)Cca>Aca	p.P160T	AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA|VWC2L_ENST00000427124.1_Intron	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	160	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						GTGTGTCAACCCAGTCTATGA	0.453000													13	41					1.3612e-06	1.59941e-06	0.024245	1	0
LOC440040	440040	broad.mit.edu	37	11	49598262	49598262	+	RNA	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:49598262C>G	ENST00000527477.1	+	0	866																											GTTCTGTAGCCATTCAGGTCC	0.483000													17	4					0	0	0.038395	0	0
EOMES	8320	broad.mit.edu	37	3	27759021	27759021	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:27759021C>A	ENST00000295743.4	-	6	1804	c.1601G>T	c.(1600-1602)aGt>aTt	p.S534I	EOMES_ENST00000537516.1_Missense_Mutation_p.S258I|EOMES_ENST00000449599.1_Missense_Mutation_p.S553I			O95936	EOMES_HUMAN	eomesodermin	534					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						TTCATAGGAACTGATGTCTAG	0.532000													31	50					1.99505e-19	3.25833e-19	0.050027	1	0
ZEB2	9839	broad.mit.edu	37	2	145157219	145157219	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:145157219C>A	ENST00000558170.2	-	8	2719	c.1535G>T	c.(1534-1536)gGt>gTt	p.G512V	ZEB2_ENST00000303660.4_Missense_Mutation_p.G512V|ZEB2_ENST00000539609.3_Missense_Mutation_p.G488V|ZEB2_ENST00000409487.3_Missense_Mutation_p.G512V	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	512						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TACCGGAAGACCGACAGGCGG	0.418000													27	28					1.17739e-12	1.65461e-12	0.027356	1	0
CSMD2	114784	broad.mit.edu	37	1	34071053	34071053	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:34071053A>T	ENST00000373381.4	-	42	6537	c.6361T>A	c.(6361-6363)Tgc>Agc	p.C2121S	CSMD2_ENST00000373380.1_Missense_Mutation_p.C994S|CSMD2_ENST00000373388.2_Missense_Mutation_p.C220S|CSMD2_ENST00000373377.1_Missense_Mutation_p.C220S	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2123	Sushi 12.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGGTCTGGGCACTCTTGAAGT	0.512000													6	14					0	0	0.021553	0	0
CCDC132	55610	broad.mit.edu	37	7	92978026	92978026	+	Silent	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:92978026A>G	ENST00000544910.1	+	25	2341	c.2121A>G	c.(2119-2121)gtA>gtG	p.V707V	CCDC132_ENST00000535481.1_Silent_p.V457V|CCDC132_ENST00000541136.1_Silent_p.V548V|CCDC132_ENST00000305866.5_Silent_p.V737V|CCDC132_ENST00000474412.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	737										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CCTTTAGGGTATTCTTGGCTG	0.398000													14	27					0	0	0.028581	0	0
JAK3	3718	broad.mit.edu	37	19	17949164	17949164	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:17949164T>A	ENST00000458235.1	-	11	1576	c.1477A>T	c.(1477-1479)Agc>Tgc	p.S493C	JAK3_ENST00000527670.1_Missense_Mutation_p.S493C|JAK3_ENST00000534444.1_Missense_Mutation_p.S493C|JAK3_ENST00000526008.1_5'UTR	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	493					B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.S493R(2)|p.S493C(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GTGGGTGGGCTGTGACCTCTC	0.512000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								22	47					0	0	0.018920	0	0
CD207	50489	broad.mit.edu	37	2	71058894	71058894	+	Silent	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:71058894T>A	ENST00000410009.3	-	5	819	c.774A>T	c.(772-774)gcA>gcT	p.A258A		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	258	C-type lectin.				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						CTTCCATCCCTGCTTTAGTCA	0.552000													24	63					0	0	0.021523	0	0
PRPF4B	8899	broad.mit.edu	37	6	4032299	4032299	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:4032299G>C	ENST00000337659.6	+	2	648	c.548G>C	c.(547-549)cGa>cCa	p.R183P	PRPF4B_ENST00000538861.1_Missense_Mutation_p.R169P	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	183	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ACAAAGAAACGAAGTAAAAGC	0.353000													85	86					0	0	0.048971	0	0
LRP1B	53353	broad.mit.edu	37	2	141114028	141114028	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:141114028A>T	ENST00000389484.3	-	75	12384	c.11413T>A	c.(11413-11415)Tgt>Agt	p.C3805S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3805	EGF-like 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATCTTCACAGGTATATTCA	0.318000										TSP Lung(27;0.18)			17	32					0	0	0.033300	0	0
AFF1	4299	broad.mit.edu	37	4	88029317	88029317	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:88029317A>T	ENST00000307808.6	+	10	1782	c.1362A>T	c.(1360-1362)ccA>ccT	p.P454P	AFF1_ENST00000544085.1_Silent_p.P92P|AFF1_ENST00000395146.4_Silent_p.P461P	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	454						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCAGTGCTCCACAGTCCCTTC	0.493000													50	74					0	0	0.048971	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91467469	91467469	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:91467469T>C	ENST00000261991.3	-	2	311	c.138A>G	c.(136-138)atA>atG	p.I46M	RPS6KA5_ENST00000536315.2_De_novo_Start_InFrame|RPS6KA5_ENST00000418736.2_Missense_Mutation_p.I46M	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	46					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CAAAATTTTCTATTCCCACCT	0.358000													10	55					0	0	0.020292	0	0
CNTN5	53942	broad.mit.edu	37	11	100061912	100061912	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:100061912C>A	ENST00000524871.1	+	14	1925	c.1635C>A	c.(1633-1635)gaC>gaA	p.D545E	CNTN5_ENST00000418526.2_Missense_Mutation_p.D471E|CNTN5_ENST00000528682.1_Missense_Mutation_p.D545E|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.D545E|CNTN5_ENST00000527185.1_Missense_Mutation_p.D545E	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	545	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCAAATCAGACGAGGGAAAGT	0.383000													53	16					1.38909e-20	2.31334e-20	0.048971	1	0
CABIN1	23523	broad.mit.edu	37	22	24509555	24509555	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr22:24509555C>T	ENST00000398319.2	+	27	4525	c.4140C>T	c.(4138-4140)gcC>gcT	p.A1380A	CABIN1_ENST00000263119.5_Silent_p.A1380A|CABIN1_ENST00000405822.2_Silent_p.A1301A	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1380					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACAGCACAGCCGTAGCACTCT	0.557000													13	40					0	0	0.013537	0	0
BIRC6	57448	broad.mit.edu	37	2	32730165	32730165	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:32730165C>T	ENST00000421745.2	+	50	9727	c.9593C>T	c.(9592-9594)tCc>tTc	p.S3198F		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3198					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GCTGCTTGGTCCTACATCTTT	0.507000													5	20					0	0	0.021553	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998043	27998043	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:27998043G>A	ENST00000441525.1	-	1	1523	c.1409C>T	c.(1408-1410)tCc>tTc	p.S470F		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	470										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						GATGATCTGGGAGGATGATTT	0.493000													24	2					0	0	0.016522	0	0
PIK3R5	23533	broad.mit.edu	37	17	8790535	8790535	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:8790535G>T	ENST00000447110.1	-	12	1907	c.1783C>A	c.(1783-1785)Ctg>Atg	p.L595M	PIK3R5_ENST00000584803.1_Missense_Mutation_p.L595M|PIK3R5_ENST00000581552.1_Missense_Mutation_p.L595M	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	595					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GTGGTGCCCAGCTCCTAGGGC	0.612000													16	2					6.49762e-13	9.22313e-13	0.038395	1	0
ZFPM2	23414	broad.mit.edu	37	8	106814331	106814331	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:106814331G>A	ENST00000407775.2	+	8	2271	c.2021G>A	c.(2020-2022)aGt>aAt	p.S674N	RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S542N|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S542N|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S405N|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520594.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	674					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAAAATCCCAGTGTCCCCTTA	0.443000													21	22					0	0	0.014323	0	0
DLAT	1737	broad.mit.edu	37	11	111921968	111921968	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:111921968G>T	ENST00000280346.6	+	11	2068	c.1409G>T	c.(1408-1410)gGg>gTg	p.G470V	DLAT_ENST00000537636.1_Missense_Mutation_p.G241V|DLAT_ENST00000393051.1_Missense_Mutation_p.G365V	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	470	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ATATTAGAAGGGAGAAGCAAA	0.333000													28	54					1.45844e-13	2.11999e-13	0.054565	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144930944	144930944	+	Silent	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:144930944T>C	ENST00000529945.1	-	1	1204	c.765A>G	c.(763-765)caA>caG	p.Q255Q	PDE4DIP_ENST00000369354.3_Intron|PDE4DIP_ENST00000313431.9_Silent_p.Q255Q|PDE4DIP_ENST00000369351.3_Intron|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369349.3_Intron|PDE4DIP_ENST00000479408.2_Intron|PDE4DIP_ENST00000369359.4_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1458					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CATCTTTCTGTTGTGGAGGGC	0.512000			T	PDGFRB	MPD								16	69					0	0	0.033300	0	0
SLC35D1	23169	broad.mit.edu	37	1	67513052	67513052	+	Splice_Site	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:67513052T>A	ENST00000235345.5	-	7	619		c.e7-2		SLC35D1_ENST00000506472.2_Splice_Site	NM_015139.2	NP_055954.1	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1						chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	AAGTCAGAGCTGCAAAACATA	0.308000													3	16					0	0	0.004672	0	0
KCNU1	157855	broad.mit.edu	37	8	36763324	36763324	+	Splice_Site	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:36763324T>A	ENST00000399881.3	+	20	2143		c.e20+2			NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1							voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GTGACTCTGGTAGGTGATCTT	0.413000													45	71					0	0	0.045515	0	0
NAV2	89797	broad.mit.edu	37	11	20070731	20070731	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:20070731C>T	ENST00000396085.1	+	15	4721	c.4360C>T	c.(4360-4362)Ctg>Ttg	p.L1454L	NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000311043.8_Silent_p.L540L|NAV2_ENST00000533917.1_Silent_p.L540L|NAV2_ENST00000527559.2_Silent_p.L1406L|NAV2_ENST00000360655.4_Silent_p.L1390L|NAV2_ENST00000396087.3_Silent_p.L1477L|NAV2_ENST00000349880.4_Silent_p.L1454L|NAV2_ENST00000540292.1_Silent_p.L1408L	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1477	Ser-rich.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GAAGACCACACTGTCAGAAAG	0.498000													64	70					0	0	0.048971	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464048	38464048	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:38464048C>A	ENST00000322350.5	+	22	3336	c.2990C>A	c.(2989-2991)gCc>gAc	p.A997D	EGFLAM_ENST00000506135.1_Missense_Mutation_p.A140D|EGFLAM_ENST00000397210.3_Missense_Mutation_p.A140D|EGFLAM_ENST00000354891.3_Missense_Mutation_p.A1005D|EGFLAM_ENST00000336740.6_Missense_Mutation_p.A763D|EGFLAM_ENST00000397202.2_Missense_Mutation_p.A363D|EGFLAM_ENST00000514476.1_Missense_Mutation_p.A140D|CTD-2263F21.1_ENST00000510469.1_RNA	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	1005	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GTGGAAGATGCCGTGGATGGG	0.517000													21	69					5.35047e-06	6.13347e-06	0.018920	1	0
ARSI	340075	broad.mit.edu	37	5	149677693	149677693	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:149677693G>T	ENST00000328668.7	-	2	1373	c.794C>A	c.(793-795)gCc>gAc	p.A265D		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	265						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTCACCATGGCCGCGTACTT	0.577000													12	13					0.00010058	0.000111084	0.013537	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21329791	21329791	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:21329791T>G	ENST00000256958.2	+	5	537	c.441T>G	c.(439-441)atT>atG	p.I147M		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	147					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTAATCAAATTTTATCACTCA	0.284000													42	11					0	0	0.030466	0	0
IFNGR2	3460	broad.mit.edu	37	21	34793812	34793812	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:34793812G>T	ENST00000290219.6	+	3	880	c.232G>T	c.(232-234)Gac>Tac	p.D78Y	IFNGR2_ENST00000405436.1_5'UTR|IFNGR2_ENST00000381995.1_Missense_Mutation_p.D97Y	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	78	Fibronectin type-III 1.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	GTTCACGGCCGACATCATGTC	0.458000													13	30					2.23348e-06	2.61707e-06	0.028581	1	0
C17orf74	201243	broad.mit.edu	37	17	7330299	7330299	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:7330299G>A	ENST00000333870.3	+	3	1063	c.989G>A	c.(988-990)cGg>cAg	p.R330Q	C17orf74_ENST00000574034.1_3'UTR|RP11-104H15.7_ENST00000575310.1_RNA	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	330						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				TCGGTGTCCCGGAACGCCCGG	0.687000													6	7					0	0	0.058154	0	0
ZEB1	6935	broad.mit.edu	37	10	31810697	31810697	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:31810697C>A	ENST00000446923.2	+	7	2777	c.2386C>A	c.(2386-2388)Ccc>Acc	p.P796T	ZEB1_ENST00000560721.2_Missense_Mutation_p.P792T|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Missense_Mutation_p.P812T|ZEB1_ENST00000542815.3_Missense_Mutation_p.P745T|ZEB1_ENST00000361642.5_Missense_Mutation_p.P813T	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	812					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGCCCAGTTACCCACAATCGT	0.468000													50	63					1.83081e-24	3.1739e-24	0.048971	1	0
NT5C1B	93034	broad.mit.edu	37	2	18745158	18745158	+	Silent	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:18745158G>C	ENST00000304081.4	-	9	1657	c.1557C>G	c.(1555-1557)ccC>ccG	p.P519P	NT5C1B_ENST00000359846.2_Silent_p.P579P|NT5C1B-RDH14_ENST00000532967.1_Silent_p.P579P|NT5C1B_ENST00000600945.1_Silent_p.P579P	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AGAAGATGTGGGGCCGGATCT	0.502000													35	29					0	0	0.025465	0	0
OVOL2	58495	broad.mit.edu	37	20	18005392	18005392	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:18005392C>A	ENST00000278780.6	-	4	958	c.716G>T	c.(715-717)gGc>gTc	p.G239V	OVOL2_ENST00000483661.1_5'UTR	NM_021220.2	NP_067043.2	Q9BRP0	OVOL2_HUMAN	ovo-like zinc finger 2	239					negative regulation of keratinocyte differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription by competitive promoter binding|regulation of cell cycle|regulation of keratinocyte proliferation|transcription, DNA-dependent	nucleus	DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(3)	6						AAACGAGCTGCCCGGATGGGC	0.577000													15	4					1.52009e-12	2.12913e-12	0.024245	1	0
ZNF540	163255	broad.mit.edu	37	19	38103085	38103085	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:38103085A>G	ENST00000592533.1	+	5	1236	c.904A>G	c.(904-906)Aaa>Gaa	p.K302E	ZNF540_ENST00000589117.1_Missense_Mutation_p.K270E|ZNF540_ENST00000316433.4_Missense_Mutation_p.K302E|ZNF540_ENST00000343599.5_Missense_Mutation_p.K302E	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTATGAATGTAAAGAATGTGG	0.299000													15	23					0	0	0.024245	0	0
CEP152	22995	broad.mit.edu	37	15	49048215	49048215	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:49048215C>T	ENST00000380950.2	-	20	3417	c.3230G>A	c.(3229-3231)tGt>tAt	p.C1077Y	CEP152_ENST00000399334.3_Missense_Mutation_p.C1077Y|CEP152_ENST00000325747.5_Missense_Mutation_p.C984Y	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1077					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TTTTGAAGAACAAGTCGACAT	0.403000													27	93					0	0	0.027356	0	0
HECW1	23072	broad.mit.edu	37	7	43400571	43400571	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:43400571G>T	ENST00000395891.1	+	6	1152	c.547G>T	c.(547-549)Gca>Tca	p.A183S	HECW1_ENST00000453890.1_Missense_Mutation_p.A183S	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	183					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CAAAAACTCGGCAGCTCCTGT	0.478000													16	36					3.45872e-05	3.89106e-05	0.028581	1	0
WDTC1	23038	broad.mit.edu	37	1	27630166	27630166	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:27630166G>A	ENST00000319394.3	+	14	2058	c.1523G>A	c.(1522-1524)cGc>cAc	p.R508H	WDTC1_ENST00000361771.3_Missense_Mutation_p.R507H	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	508							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		AGCACGAGCCGCAAGGACTCC	0.587000													3	64					0	0	0.004672	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178699950	178699950	+	Missense_Mutation	SNP	G	G	T	rs149308698		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:178699950G>T	ENST00000251582.7	-	3	751	c.650C>A	c.(649-651)aCg>aAg	p.T217K	ADAMTS2_ENST00000274609.5_Missense_Mutation_p.T217K	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	217					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGGAGGGGACGTGGGTGGCCG	0.672000													9	7					2.74318e-10	3.59246e-10	0.058154	1	0
TRAV8-6	28680	broad.mit.edu	37	14	22447181	22447181	+	RNA	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:22447181G>T	ENST00000390443.3	+	0	382																											ATCTCTTCTGGTATGTGCAAT	0.478000											OREG0022573	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	274					2.165e-29	3.83178e-29	0.048971	1	0
KCTD3	51133	broad.mit.edu	37	1	215793797	215793797	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:215793797G>T	ENST00000259154.4	+	18	2579	c.2285G>T	c.(2284-2286)gGa>gTa	p.G762V	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	762						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TTTGAAGGGGGAGGATTCCTT	0.418000													71	55					2.42712e-22	4.15657e-22	0.048971	1	0
TRHR	7201	broad.mit.edu	37	8	110099765	110099765	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:110099765A>T	ENST00000518632.1	+	2	375	c.24A>T	c.(22-24)gaA>gaT	p.E8D	TRHR_ENST00000311762.2_Missense_Mutation_p.E8D			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	8						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CAGTCAGTGAACTGAACCAAA	0.453000													44	49					0	0	0.048971	0	0
CDH11	1009	broad.mit.edu	37	16	65026938	65026938	+	Splice_Site	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:65026938C>A	ENST00000394156.3	-	5	977		c.e5-1		CDH11_ENST00000268603.4_Splice_Site|CDH11_ENST00000566827.1_Splice_Site			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)						adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.?(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTGACGTTCCTTAAAAGTGA	0.368000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			37	58					1.22674e-20	2.05104e-20	0.033182	1	0
NUP205	23165	broad.mit.edu	37	7	135262700	135262700	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:135262700C>T	ENST00000285968.6	+	6	831	c.805C>T	c.(805-807)Ctg>Ttg	p.L269L	NUP205_ENST00000440390.2_Silent_p.L63L	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	269					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TGCAGTGAATCTGGCTCTTCT	0.423000													29	31					0	0	0.037714	0	0
NTRK2	4915	broad.mit.edu	37	9	87549120	87549120	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:87549120G>C	ENST00000376214.1	+	17	2615	c.1677G>C	c.(1675-1677)gaG>gaC	p.E559D	NTRK2_ENST00000277120.3_Missense_Mutation_p.E559D|NTRK2_ENST00000323115.4_Missense_Mutation_p.E543D|NTRK2_ENST00000376213.1_Missense_Mutation_p.E543D	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	543	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity	p.E559D(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TGAAAAGGGAGCTAGGCGAAG	0.448000										TSP Lung(25;0.17)			25	26					0	0	0.018920	0	0
BRD9	65980	broad.mit.edu	37	5	881275	881275	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:881275C>T	ENST00000323510.4	-	6	700	c.701G>A	c.(700-702)gGg>gAg	p.G234E	BRD9_ENST00000388890.4_Missense_Mutation_p.G214E|BRD9_ENST00000483173.1_Missense_Mutation_p.G277E|BRD9_ENST00000435709.2_Intron|BRD9_ENST00000467963.1_Missense_Mutation_p.G330E|BRD9_ENST00000494422.1_Intron			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	330							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCTCCCGTCCCCGTTCCTCTT	0.597000													9	44					0	0	0.058154	0	0
ASPHD1	253982	broad.mit.edu	37	16	29916211	29916211	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:29916211G>A	ENST00000308748.5	+	2	1240	c.988G>A	c.(988-990)Ggt>Agt	p.G330S	ASPHD1_ENST00000483405.1_Missense_Mutation_p.G49S	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	330					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						GGTGGTCGGCGGTGAGCCCCA	0.617000													10	10					0	0	0.016723	0	0
FBN2	2201	broad.mit.edu	37	5	127645716	127645716	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:127645716G>A	ENST00000508053.1	-	46	6133	c.5159C>T	c.(5158-5160)cCa>cTa	p.P1720L	FBN2_ENST00000262464.4_Missense_Mutation_p.P1720L			P35556	FBN2_HUMAN	fibrillin 2	1720	EGF-like 28; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GTACTCAGGTGGGCAAATGCA	0.463000													35	61					0	0	0.059317	0	0
JADE1	79960	broad.mit.edu	37	4	129783000	129783000	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:129783000G>A	ENST00000226319.6	+	9	1403	c.1123G>A	c.(1123-1125)Gag>Aag	p.E375K	PHF17_ENST00000413543.2_Missense_Mutation_p.E375K|PHF17_ENST00000512960.1_Missense_Mutation_p.E375K|PHF17_ENST00000511647.1_Missense_Mutation_p.E375K|PHF17_ENST00000452328.2_Missense_Mutation_p.E363K	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		375					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TAGGAAACCCGAGGAGAGTCT	0.562000													81	122					0	0	0.048971	0	0
ABCC1	4363	broad.mit.edu	37	16	16173268	16173268	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:16173268G>A	ENST00000399408.2	+	16	2223	c.2048G>A	c.(2047-2049)gGa>gAa	p.G683E	ABCC1_ENST00000345148.5_Missense_Mutation_p.G683E|ABCC1_ENST00000351154.5_Missense_Mutation_p.G683E|ABCC1_ENST00000346370.5_Missense_Mutation_p.G683E|ABCC1_ENST00000349029.5_Missense_Mutation_p.G683E|ABCC1_ENST00000399410.3_Missense_Mutation_p.G683E			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	683	ABC transporter 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTGGGCTGCGGAAAGTCGTCC	0.612000													13	15					0	0	0.016723	0	0
STAB2	55576	broad.mit.edu	37	12	104086627	104086627	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:104086627A>G	ENST00000388887.2	+	31	3539	c.3335A>G	c.(3334-3336)gAc>gGc	p.D1112G		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1112	FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTCGATGGGGACAACGCAGCC	0.453000													11	9					0	0	0.016723	0	0
ZNF8	7554	broad.mit.edu	37	19	58805982	58805982	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:58805982G>T	ENST00000196548.5	+	4	939	c.808G>T	c.(808-810)Gca>Tca	p.A270S	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TAACCATAACGCACACCTCAC	0.493000													21	26					1.96292e-10	2.58665e-10	0.055883	1	0
CSDE1	7812	broad.mit.edu	37	1	115280655	115280655	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:115280655C>G	ENST00000438362.2	-	4	754	c.376G>C	c.(376-378)Ggg>Cgg	p.G126R	CSDE1_ENST00000369530.1_Missense_Mutation_p.G126R|CSDE1_ENST00000261443.5_Missense_Mutation_p.G80R|CSDE1_ENST00000530886.1_5'UTR|CSDE1_ENST00000358528.4_Missense_Mutation_p.G80R|CSDE1_ENST00000534699.1_Missense_Mutation_p.G80R|CSDE1_ENST00000339438.6_Missense_Mutation_p.G80R	NM_001242891.1	NP_001229820.1	O75534	CSDE1_HUMAN	cold shock domain containing E1, RNA-binding	80					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			NS(1)|breast(4)|endometrium(11)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	51	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGGGTTTCCCAGTCCGTCGG	0.353000													21	24					0	0	0.016522	0	0
FAM133A	286499	broad.mit.edu	37	X	92964468	92964468	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:92964468C>A	ENST00000538690.1	+	5	611	c.50C>A	c.(49-51)gCc>gAc	p.A17D	FAM133A_ENST00000355813.5_Missense_Mutation_p.A17D|FAM133A_ENST00000332647.4_Missense_Mutation_p.A17D|FAM133A_ENST00000322139.4_Missense_Mutation_p.A17D	NM_001171110.1	NP_001164581.1	Q8N9E0	F133A_HUMAN	family with sequence similarity 133, member A	17										breast(2)|endometrium(2)|large_intestine(8)|lung(7)|upper_aerodigestive_tract(1)	20						ATAGCAATGGCCAGATGGAGA	0.463000													13	6					4.14922e-12	5.73568e-12	0.028581	1	0
TRPM1	4308	broad.mit.edu	37	15	31327786	31327786	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:31327786G>T	ENST00000542188.1	-	20	3027	c.2714C>A	c.(2713-2715)tCc>tAc	p.S905Y	RP11-348B17.1_ENST00000558755.1_RNA|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000397795.2_Missense_Mutation_p.S866Y|TRPM1_ENST00000256552.6_Missense_Mutation_p.S888Y	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	866					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CACGATGTAGGAGATGACGAT	0.542000													16	21					3.41278e-10	4.44187e-10	0.033300	1	0
NLRP3	114548	broad.mit.edu	37	1	247599354	247599354	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:247599354T>C	ENST00000336119.3	+	6	3327	c.2581T>C	c.(2581-2583)Tat>Cat	p.Y861H	NLRP3_ENST00000366496.2_Intron|NLRP3_ENST00000391827.2_Missense_Mutation_p.Y804H|NLRP3_ENST00000348069.2_Intron|NLRP3_ENST00000391828.3_Missense_Mutation_p.Y861H|NLRP3_ENST00000366497.2_Intron	NM_001127462.2|NM_001243133.1|NM_004895.4	NP_001120934.1|NP_001230062.1|NP_004886.3	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	861			Y -> C (in CINCA).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACCAGACTCTATGTGGGGGA	0.488000													23	105					0	0	0.019004	0	0
TIAM1	7074	broad.mit.edu	37	21	32554806	32554806	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:32554806G>T	ENST00000286827.3	-	16	3290	c.2819C>A	c.(2818-2820)cCg>cAg	p.P940Q	TIAM1_ENST00000541036.1_Missense_Mutation_p.P880Q	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	940					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCGGTGGGGCGGGCTTTCCAG	0.637000													4	9					0.0215528	0.0223451	0.021553	1	0
MEIS2	4212	broad.mit.edu	37	15	37329140	37329140	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:37329140C>A	ENST00000338564.5	-	9	1221	c.775G>T	c.(775-777)Gta>Tta	p.V259L	MEIS2_ENST00000424352.2_Missense_Mutation_p.V259L|MEIS2_ENST00000444725.1_Missense_Mutation_p.V259L|MEIS2_ENST00000561208.1_Missense_Mutation_p.V259L|MEIS2_ENST00000557796.2_Missense_Mutation_p.V246L|MEIS2_ENST00000397620.2_Missense_Mutation_p.V171L|MEIS2_ENST00000559085.1_Missense_Mutation_p.V246L|MEIS2_ENST00000559561.1_Missense_Mutation_p.V259L|MEIS2_ENST00000340545.5_Missense_Mutation_p.V246L|MEIS2_ENST00000397624.3_Missense_Mutation_p.V171L|MEIS2_ENST00000219869.9_Missense_Mutation_p.V113L|MEIS2_ENST00000382766.2_Missense_Mutation_p.V259L	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	259	Asp/Glu-rich (acidic).				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		GGTGAAGCTACACTGTTGTCT	0.413000													37	37					5.71845e-15	8.7011e-15	0.023175	1	0
HRNR	388697	broad.mit.edu	37	1	152193090	152193090	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:152193090C>T	ENST00000368801.2	-	3	1090	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	339					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAGACTCATAATGGCCA	0.582000													16	19					0	0	0.033300	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450946	85450946	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:85450946G>T	ENST00000393217.2	+	8	2436	c.2375G>T	c.(2374-2376)tGg>tTg	p.W792L		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	792								p.W792L(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TGTGGCCCTTGGGATACTTTA	0.318000													134	136					3.29933e-67	6.25837e-67	0.048971	1	0
EIF1AD	84285	broad.mit.edu	37	11	65767113	65767113	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:65767113C>T	ENST00000312234.2	-	4	564	c.230G>A	c.(229-231)gGa>gAa	p.G77E	EIF1AD_ENST00000526451.1_Missense_Mutation_p.G77E|EIF1AD_ENST00000525767.1_Missense_Mutation_p.G25E|EIF1AD_ENST00000527249.1_Missense_Mutation_p.G77E|EIF1AD_ENST00000533544.1_Missense_Mutation_p.G77E	NM_001242481.1|NM_001242482.1|NM_001242483.1|NM_032325.3	NP_001229410.1|NP_001229411.1|NP_001229412.1|NP_115701.2	Q8N9N8	EIF1A_HUMAN	eukaryotic translation initiation factor 1A domain containing	77	S1-like.					nucleus	translation initiation factor activity			lung(5)	5						CACCTTTTCTCCCTCTTCAAT	0.493000													30	58					0	0	0.054565	0	0
DIRC2	84925	broad.mit.edu	37	3	122598179	122598179	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:122598179G>T	ENST00000261038.5	+	9	1789	c.1391G>T	c.(1390-1392)aGg>aTg	p.R464M		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	464					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		CTGTGCTTCAGGGAATCCTAT	0.438000													109	183					4.10022e-50	7.6743e-50	0.048971	1	0
XIRP2	129446	broad.mit.edu	37	2	167760302	167760302	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:167760302C>T	ENST00000409195.1	+	2	399	c.310C>T	c.(310-312)Cgg>Tgg	p.R104W	XIRP2_ENST00000295237.9_Missense_Mutation_p.R104W|XIRP2_ENST00000420519.1_Missense_Mutation_p.R104W|XIRP2_ENST00000409728.1_Missense_Mutation_p.R104W|XIRP2_ENST00000409756.2_Missense_Mutation_p.R104W|XIRP2_ENST00000409043.1_Missense_Mutation_p.R104W	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CCTGAGCAGTCGGCGCAGGAT	0.517000													36	22					0	0	0.054565	0	0
PLCD4	84812	broad.mit.edu	37	2	219498867	219498867	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:219498867G>A	ENST00000450993.2	+	12	1985	c.1646G>A	c.(1645-1647)cGt>cAt	p.R549H	PLCD4_ENST00000417849.1_Missense_Mutation_p.R549H|PLCD4_ENST00000432688.1_Missense_Mutation_p.R581H	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	549	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CAGTTAAGCCGTGTGTATCCC	0.552000													8	6					0	0	0.047766	0	0
TMEM87A	25963	broad.mit.edu	37	15	42525442	42525442	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:42525442G>T	ENST00000389834.4	-	11	1295	c.1031C>A	c.(1030-1032)tCt>tAt	p.S344Y	TMEM87A_ENST00000448392.1_Missense_Mutation_p.S283Y	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	344						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		TTCCATGCCAGAGAACAAAAG	0.433000													55	42					7.91745e-34	1.44357e-33	0.048971	1	0
SLC17A9	63910	broad.mit.edu	37	20	61598073	61598073	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:61598073G>T	ENST00000370349.3	+	13	1322	c.1118G>T	c.(1117-1119)gGg>gTg	p.G373V	SLC17A9_ENST00000370351.4_Missense_Mutation_p.G379V|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	379					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						AACACAGCCGGGGCCTTGGCA	0.652000													4	12					0.000442599	0.000478822	0.058154	1	0
TRIM15	89870	broad.mit.edu	37	6	30138770	30138770	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:30138770C>A	ENST00000376694.4	+	6	1334	c.865C>A	c.(865-867)Ctg>Atg	p.L289M	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	289	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GGCGCATCATCTGGAAATAGA	0.423000													60	84					5.10652e-33	9.23102e-33	0.048971	1	0
APOB	338	broad.mit.edu	37	2	21234284	21234284	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:21234284A>T	ENST00000233242.1	-	26	5583	c.5456T>A	c.(5455-5457)cTg>cAg	p.L1819Q		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1819					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGCAGCTTCAGGGGTTCTAG	0.418000													63	63					0	0	0.048971	0	0
STOX1	219736	broad.mit.edu	37	10	70645139	70645139	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:70645139G>T	ENST00000298596.6	+	3	1670	c.1587G>T	c.(1585-1587)aaG>aaT	p.K529N	STOX1_ENST00000399169.4_Missense_Mutation_p.K529N|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.K419N	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	529						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CAAAGGAAAAGCCTTTCCAAA	0.438000													21	18					5.26018e-13	7.51708e-13	0.062417	1	0
CECR2	27443	broad.mit.edu	37	22	18021558	18021558	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr22:18021558C>A	ENST00000262608.8	+	14	1852	c.1852C>A	c.(1852-1854)Ctg>Atg	p.L618M	CECR2_ENST00000400573.4_Missense_Mutation_p.L617M|CECR2_ENST00000400585.2_Missense_Mutation_p.L476M	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	659					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		ATTTGGCCCTCTGCGAGGATC	0.552000													10	42					1.76689e-08	2.16637e-08	0.058154	1	0
LILRP2	79166	broad.mit.edu	37	19	55221659	55221659	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:55221659C>A	ENST00000413439.1	+	0	1415																											CAGGTTCAGTCAGGGACCCAC	0.652000													9	13					0.00448238	0.00477594	0.047766	1	0
APOB	338	broad.mit.edu	37	2	21225226	21225226	+	Silent	SNP	A	A	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:21225226A>C	ENST00000233242.1	-	29	13195	c.13068T>G	c.(13066-13068)ctT>ctG	p.L4356L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4356					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAACTTATGAAGATTAAGGC	0.313000													4	23					0	0	0.021553	0	0
SGIP1	84251	broad.mit.edu	37	1	67091582	67091582	+	Missense_Mutation	SNP	C	C	A	rs149425441		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:67091582C>A	ENST00000371037.4	+	2	140	c.63C>A	c.(61-63)gaC>gaA	p.D21E	SGIP1_ENST00000371035.3_Missense_Mutation_p.D21E|SGIP1_ENST00000371036.3_Missense_Mutation_p.D20E|SGIP1_ENST00000371039.1_Missense_Mutation_p.D21E|SGIP1_ENST00000237247.6_Missense_Mutation_p.D21E|SGIP1_ENST00000468286.1_3'UTR	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	21					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AAGAAAAGGACACTGATTCTA	0.403000													11	47					1.41608e-15	2.19414e-15	0.016723	1	0
CPEB1	64506	broad.mit.edu	37	15	83221331	83221331	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:83221331C>A	ENST00000563800.1	-	8	2905	c.1180G>T	c.(1180-1182)Gtc>Ttc	p.V394F	CPEB1_ENST00000568757.1_Missense_Mutation_p.V292F|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000568128.1_Missense_Mutation_p.V367F|CPEB1_ENST00000564522.1_Missense_Mutation_p.V292F|CPEB1_ENST00000562019.1_Missense_Mutation_p.V372F|CPEB1_ENST00000261723.6_Missense_Mutation_p.V370F|RP11-152F13.10_ENST00000562833.1_Silent_p.L101L|CPEB1_ENST00000450751.2_Missense_Mutation_p.V292F|CPEB1_ENST00000423133.2_Missense_Mutation_p.V292F|CPEB1_ENST00000398591.2_Missense_Mutation_p.V297F|CPEB1_ENST00000398592.2_Missense_Mutation_p.V141F			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	372	Necessary for stress granule assembly and correct localization in dcp1 bodies.|RRM 1.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			AAGGATCGGACAGACTTCTCT	0.493000													29	102					4.74835e-14	7.02292e-14	0.045705	1	0
DSC3	1825	broad.mit.edu	37	18	28604434	28604434	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:28604434T>C	ENST00000434452.1	-	6	810	c.656A>G	c.(655-657)gAt>gGt	p.D219G	DSC3_ENST00000360428.4_Missense_Mutation_p.D219G	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	219	Cadherin 1.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TGAATATCCATCTGCAGTTGA	0.398000													16	18					0	0	0.038395	0	0
C8orf46	254778	broad.mit.edu	37	8	67422390	67422390	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:67422390C>T	ENST00000305454.3	+	4	781	c.340C>T	c.(340-342)Ctg>Ttg	p.L114L	C8orf46_ENST00000521495.1_Silent_p.L114L|C8orf46_ENST00000480005.1_Silent_p.L114L|C8orf46_ENST00000482608.2_3'UTR|C8orf46_ENST00000522977.1_Intron	NM_152765.3	NP_689978.2	Q8TAG6	CH046_HUMAN	chromosome 8 open reading frame 46	114										endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|skin(2)	6			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TGGAAAATCTCTGGTAAGTAA	0.408000													9	14					0	0	0.058154	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144297261	144297261	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:144297261G>T	ENST00000330824.2	+	4	498	c.423G>T	c.(421-423)tgG>tgT	p.W141C		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	141	UPAR/Ly6.				cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TCCCACCCTGGCAAAGCTCCC	0.672000													7	0					1.76689e-08	2.16637e-08	0.058154	1	0
SYNE1	23345	broad.mit.edu	37	6	152716805	152716805	+	Splice_Site	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:152716805A>T	ENST00000367255.5	-	51	8159	c.7556_splice	c.e51-1	p.F2520_splice	SYNE1_ENST00000341594.5_Splice_Site_p.F2559_splice|SYNE1_ENST00000448038.1_Splice_Site_p.F2527_splice|SYNE1_ENST00000265368.4_Splice_Site_p.F2520_splice|SYNE1_ENST00000423061.1_Splice_Site_p.F2527_splice	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2520					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGATCTTCAAAGCTAAGGGAA	0.348000										HNSCC(10;0.0054)			11	26					0	0	0.010729	0	0
SEC61G	23480	broad.mit.edu	37	7	54826849	54826849	+	Splice_Site	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:54826849A>G	ENST00000415949.1	-	2	361		c.e2+1		SEC61G_ENST00000352861.4_Splice_Site|SEC61G_ENST00000450622.1_5'UTR|SEC61G_ENST00000395535.3_Intron			P60059	SC61G_HUMAN	Sec61 gamma subunit						protein targeting to ER	endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|lung(5)	6	Esophageal squamous(2;7.55e-08)|Breast(14;0.0654)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)			GAAGAAACTCACCTACCCAAC	0.667000													14	19					0	0	0.038395	0	0
NMNAT2	23057	broad.mit.edu	37	1	183387385	183387385	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:183387385C>A	ENST00000287713.6	-	1	352	c.18G>T	c.(16-18)aaG>aaT	p.K6N		NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	6					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						TAACGTGGGTCTTGGTGGTCT	0.567000													21	121					9.57634e-11	1.2819e-10	0.018920	1	0
IGHV3OR16-8	388255	broad.mit.edu	37	16	33020936	33020936	+	RNA	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:33020936G>T	ENST00000565407.2	+	0	344				RP11-19N8.2_ENST00000567619.1_RNA																							GTGTATTACTGTGTGAAACAC	0.572000													71	83					2.51111e-31	4.51999e-31	0.048971	1	0
LRRC66	339977	broad.mit.edu	37	4	52861973	52861973	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:52861973C>A	ENST00000343457.3	-	4	1221	c.1215G>T	c.(1213-1215)tgG>tgT	p.W405C		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	405						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ACTTTTTTTGCCACAGTCTGT	0.562000													34	37					1.836e-18	2.97559e-18	0.064281	1	0
NPY6R	4888	broad.mit.edu	37	5	137144163	137144163	+	RNA	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:137144163G>C	ENST00000510937.1	+	0	711					NR_002713.3																						TGTGTGTCATGTGCATCCATT	0.433000													34	36					0	0	0.023175	0	0
PCDH15	65217	broad.mit.edu	37	10	55892655	55892655	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:55892655C>A	ENST00000373965.2	-	16	2312	c.1918G>T	c.(1918-1920)Gct>Tct	p.A640S	PCDH15_ENST00000414778.1_Missense_Mutation_p.A638S|PCDH15_ENST00000395438.1_Missense_Mutation_p.A633S|PCDH15_ENST00000320301.6_Missense_Mutation_p.A633S|PCDH15_ENST00000395445.1_Missense_Mutation_p.A640S|PCDH15_ENST00000409834.1_Missense_Mutation_p.A244S|PCDH15_ENST00000373957.3_Missense_Mutation_p.A611S|PCDH15_ENST00000395432.2_Missense_Mutation_p.A596S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.A633S|PCDH15_ENST00000361849.3_Missense_Mutation_p.A633S|PCDH15_ENST00000395446.1_Missense_Mutation_p.A633S|PCDH15_ENST00000395433.1_Missense_Mutation_p.A611S|PCDH15_ENST00000373955.1_Missense_Mutation_p.A633S|PCDH15_ENST00000437009.1_Intron|PCDH15_ENST00000395440.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	633	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AATAAAACAGCACCAACCCTC	0.393000										HNSCC(58;0.16)			15	27					3.52763e-06	4.09942e-06	0.033300	1	0
TRIM48	79097	broad.mit.edu	37	11	55032720	55032720	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:55032720T>A	ENST00000417545.2	+	2	475	c.389T>A	c.(388-390)cTg>cAg	p.L130Q		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	114						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CTCTGTTTGCTGTGCTCCAGC	0.517000													16	8					0	0	0.033300	0	0
NPY2R	4887	broad.mit.edu	37	4	156135259	156135259	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:156135259C>A	ENST00000329476.3	+	2	657	c.168C>A	c.(166-168)gcC>gcA	p.A56A	NPY2R_ENST00000506608.1_Silent_p.A56A	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	56					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				TCATATTGGCCTACTGCTCCA	0.463000													38	43					1.30998e-17	2.08317e-17	0.023175	1	0
GABRA5	2558	broad.mit.edu	37	15	27182421	27182421	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:27182421C>A	ENST00000335625.5	+	8	1558	c.670C>A	c.(670-672)Cag>Aag	p.Q224K	GABRA5_ENST00000355395.5_Missense_Mutation_p.Q224K|GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000400081.3_Missense_Mutation_p.Q224K	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	224					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGACTGAACCAGTACCACCT	0.597000													6	25					3.59834e-05	4.03739e-05	0.021553	1	0
FLRT2	23768	broad.mit.edu	37	14	86088719	86088719	+	Silent	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:86088719A>G	ENST00000330753.4	+	2	1628	c.861A>G	c.(859-861)caA>caG	p.Q287Q	FLRT2_ENST00000554746.1_Silent_p.Q287Q	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	287					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CCAACAACCAACTGCGGATGC	0.458000													78	235					0	0	0.048971	0	0
SPAG16	79582	broad.mit.edu	37	2	214878756	214878756	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:214878756C>A	ENST00000331683.5	+	13	1577	c.1482C>A	c.(1480-1482)ctC>ctA	p.L494L	SPAG16_ENST00000374309.3_Silent_p.L400L	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	494					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ATACTCTTCTCACAAGCTCTG	0.373000													33	33					9.62906e-15	1.45468e-14	0.025465	1	0
CERS6	253782	broad.mit.edu	37	2	169574413	169574413	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:169574413A>T	ENST00000305747.6	+	8	1357	c.770A>T	c.(769-771)cAg>cTg	p.Q257L	CERS6_ENST00000392687.4_Missense_Mutation_p.Q257L	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	257	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GCCAAGTTTCAGAAAATGTGT	0.363000													13	18					0	0	0.013537	0	0
ZNF536	9745	broad.mit.edu	37	19	31039059	31039059	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:31039059C>A	ENST00000355537.3	+	4	2680	c.2533C>A	c.(2533-2535)Ctc>Atc	p.L845I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	845					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.L845V(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTTCAAGGGTCTCCCTGGAAT	0.572000													27	28					1.13719e-10	1.51745e-10	0.037714	1	0
OR52E4	390081	broad.mit.edu	37	11	5906249	5906249	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:5906249G>T	ENST00000316987.2	+	1	749	c.727G>T	c.(727-729)Ggt>Tgt	p.G243C		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAATACCTGTGGTTCTCATGT	0.408000													21	73					6.44725e-10	8.28932e-10	0.014323	1	0
RABEPK	10244	broad.mit.edu	37	9	127996228	127996228	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:127996228A>G	ENST00000373538.3	+	8	1398	c.1088A>G	c.(1087-1089)tAt>tGt	p.Y363C	RABEPK_ENST00000394125.4_Missense_Mutation_p.Y363C|RABEPK_ENST00000259460.8_Missense_Mutation_p.Y312C|RABEPK_ENST00000394124.4_3'UTR	NM_005833.3	NP_005824.2	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	363					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						GGGGAAATCTATGACGATTGT	0.383000													70	67					0	0	0.048971	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000431	73000431	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:73000431G>T	ENST00000322038.5	+	2	3518	c.2934G>T	c.(2932-2934)ctG>ctT	p.L978L	TSHZ1_ENST00000580243.1_Silent_p.L1023L	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	1023						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACAAAACTCTGGGCCCACTGG	0.517000													27	37					2.46105e-21	4.14751e-21	0.045705	1	0
KLK7	5650	broad.mit.edu	37	19	51480936	51480936	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:51480936C>A	ENST00000391807.1	-	6	719	c.618G>T	c.(616-618)ggG>ggT	p.G206G	KLK7_ENST00000595820.1_Silent_p.G206G|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000336317.4_Silent_p.G93G|KLK7_ENST00000597707.1_Silent_p.G134G	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	206	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		CCAACGGTCCCCCTGAGTCAC	0.517000													5	3					0.014758	0.0153382	0.014758	1	0
HMCN1	83872	broad.mit.edu	37	1	186086595	186086595	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:186086595A>T	ENST00000271588.4	+	77	11917	c.11688A>T	c.(11686-11688)ccA>ccT	p.P3896P	HMCN1_ENST00000367492.2_Silent_p.P3896P	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3896					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTTTAGTTCCACCTTCCATAG	0.403000													36	25					0	0	0.023175	0	0
SI	6476	broad.mit.edu	37	3	164700808	164700808	+	Silent	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:164700808T>A	ENST00000264382.3	-	46	5291	c.5229A>T	c.(5227-5229)gtA>gtT	p.V1743V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1743	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATTAAATTGTACAGATAAAT	0.323000										HNSCC(35;0.089)			10	20					0	0	0.008291	0	0
HRNR	388697	broad.mit.edu	37	1	152192588	152192588	+	Missense_Mutation	SNP	C	C	T	rs140120787	byFrequency	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:152192588C>T	ENST00000368801.2	-	3	1592	c.1517G>A	c.(1516-1518)cGa>cAa	p.R506Q	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	506					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATCCTTGTCGTTCACCCCT	0.562000													30	69					0	0	0.041601	0	0
ZNF620	253639	broad.mit.edu	37	3	40557709	40557709	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:40557709G>A	ENST00000314529.6	+	5	773	c.624G>A	c.(622-624)atG>atA	p.M208I	ZNF620_ENST00000418905.1_Missense_Mutation_p.M94I	NM_175888.3	NP_787084.1	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(1)|urinary_tract(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		TCATTCAAATGGCAGACTTCC	0.368000													19	40					0	0	0.049695	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379344	114379344	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:114379344T>A	ENST00000312719.5	-	5	1306	c.118A>T	c.(118-120)Att>Ttt	p.I40F	RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|HS3ST5_ENST00000411826.1_Missense_Mutation_p.I40F|RP3-399L15.3_ENST00000523087.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	40					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		ATGGGGCAAATGGGTTGTAGC	0.502000													7	7					0	0	0.029380	0	0
ZNF620	253639	broad.mit.edu	37	3	40558265	40558265	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:40558265T>C	ENST00000314529.6	+	5	1329	c.1180T>C	c.(1180-1182)Tgt>Cgt	p.C394R	ZNF620_ENST00000418905.1_Missense_Mutation_p.C280R	NM_175888.3	NP_787084.1	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(1)|urinary_tract(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		ACCTTATGAGTGTAAAGTGTG	0.453000													31	37					0	0	0.037714	0	0
MYBL2	4605	broad.mit.edu	37	20	42331376	42331376	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:42331376G>T	ENST00000217026.4	+	8	1325	c.1198G>T	c.(1198-1200)Ggc>Tgc	p.G400C	MYBL2_ENST00000396863.4_Missense_Mutation_p.G376C	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	400						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.G400C(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGAAGTCGGGGGCTCTGGCAT	0.632000													22	28					6.44725e-10	8.28932e-10	0.014323	1	0
ZNF586	54807	broad.mit.edu	37	19	58290168	58290168	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:58290168G>A	ENST00000396150.4	+	2	233	c.86G>A	c.(85-87)cGt>cAt	p.R29H	ZNF586_ENST00000599802.1_Intron|ZNF586_ENST00000391702.3_Silent_p.T28T|ZNF586_ENST00000396154.2_Silent_p.T71T|ZNF586_ENST00000598885.1_Intron|ZNF586_ENST00000598183.1_Intron	NM_001077426.2	NP_001070894.1	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)	15		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGCAGAGCACGTGTATACATA	0.438000													9	36					0	0	0.013537	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215064	140215064	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:140215064G>T	ENST00000525929.1	+	1	1096	c.1096G>T	c.(1096-1098)Ggt>Tgt	p.G366C	PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.G366C	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCAACCAGGTACCGTCAT	0.502000													23	45					1.22574e-08	1.51604e-08	0.014323	1	0
ADAMTSL4	54507	broad.mit.edu	37	1	150531856	150531856	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:150531856T>A	ENST00000271643.4	+	17	3093	c.2857T>A	c.(2857-2859)Tgt>Agt	p.C953S	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.C953S|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.C976S	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	953	TSP type-1 5.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TCCGAGCAACTGTTCTCACCT	0.597000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	7					0	0	0.016723	0	0
RANBP3L	202151	broad.mit.edu	37	5	36265170	36265170	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:36265170C>A	ENST00000296604.3	-	6	856	c.371G>T	c.(370-372)aGa>aTa	p.R124I	RANBP3L_ENST00000515759.1_Missense_Mutation_p.R124I|RANBP3L_ENST00000502994.1_Missense_Mutation_p.R149I	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	124					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			AATAGCAGGTCTAATAACATG	0.313000													16	49					6.72482e-11	9.05924e-11	0.024245	1	0
PHIP	55023	broad.mit.edu	37	6	79770483	79770483	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:79770483C>A	ENST00000275034.4	-	5	409	c.242G>T	c.(241-243)cGa>cTa	p.R81L		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	81					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AGGTCCTAGTCGATGACATAT	0.348000													31	42					6.90743e-12	9.4865e-12	0.064281	1	0
REG3G	130120	broad.mit.edu	37	2	79253249	79253249	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:79253249G>A	ENST00000272324.5	+	2	214	c.30G>A	c.(28-30)gtG>gtA	p.V10V	REG3G_ENST00000393897.2_Silent_p.V10V|REG3G_ENST00000409471.1_Silent_p.V10V	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	10					acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGCCCAGTGTGTCCTGGATGC	0.542000													18	20					0	0	0.014323	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965765	88965765	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:88965765A>T	ENST00000333190.4	+	4	4078	c.3469A>T	c.(3469-3471)Aaa>Taa	p.K1157*		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1157						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CGAAATAGATAAATATAAGAT	0.428000										HNSCC(36;0.09)			39	48					0	0	0.025465	0	0
UROC1	131669	broad.mit.edu	37	3	126226902	126226902	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:126226902C>A	ENST00000290868.2	-	5	501	c.448G>T	c.(448-450)Gag>Tag	p.E150*	UROC1_ENST00000383579.3_Nonsense_Mutation_p.E150*	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	150					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		GTCTGCTCCTCTGTCATCTTC	0.587000													25	34					1.77063e-15	2.73349e-15	0.027356	1	0
CTNND2	1501	broad.mit.edu	37	5	11022947	11022947	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:11022947G>C	ENST00000304623.8	-	17	3122	c.2933C>G	c.(2932-2934)gCc>gGc	p.A978G	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.A920G|CTNND2_ENST00000503622.1_Missense_Mutation_p.A641G|CTNND2_ENST00000458100.2_Missense_Mutation_p.A545G|CTNND2_ENST00000511377.1_Missense_Mutation_p.A887G	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	978					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TAAGGCCTTGGCGTTCTCCAT	0.512000													36	137					0	0	0.064281	0	0
ASTN2	23245	broad.mit.edu	37	9	119582938	119582938	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:119582938A>T	ENST00000313400.4	-	12	2265	c.2165T>A	c.(2164-2166)cTg>cAg	p.L722Q	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.L718Q|ASTN2_ENST00000361209.2_Missense_Mutation_p.L671Q			O75129	ASTN2_HUMAN	astrotactin 2	722	EGF-like 3.					integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						ATCGTAGGGCAGGGGCAGCGT	0.582000													31	57					0	0	0.059317	0	0
DOCK2	1794	broad.mit.edu	37	5	169122824	169122824	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:169122824C>G	ENST00000256935.8	+	10	941	c.861C>G	c.(859-861)gaC>gaG	p.D287E		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	287					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAACAAAGACCTCAACAGGG	0.418000													48	55					0	0	0.048971	0	0
SLIT2	9353	broad.mit.edu	37	4	20543212	20543212	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:20543212G>T	ENST00000504154.1	+	20	2365	c.2113G>T	c.(2113-2115)Gtg>Ttg	p.V705L	SLIT2_ENST00000503823.1_Missense_Mutation_p.V697L|SLIT2_ENST00000273739.5_Missense_Mutation_p.V709L|SLIT2_ENST00000503837.1_Missense_Mutation_p.V701L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	705	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CATCCAGGATGTGGCCATTCA	0.438000													18	23					1.56452e-12	2.17695e-12	0.043863	1	0
MAP7D1	55700	broad.mit.edu	37	1	36645329	36645329	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:36645329G>C	ENST00000316156.4	+	14	2632	c.2179G>C	c.(2179-2181)Gag>Cag	p.E727Q	MAP7D1_ENST00000373148.4_Missense_Mutation_p.E301Q|MAP7D1_ENST00000373150.4_Missense_Mutation_p.E732Q|MAP7D1_ENST00000373151.2_Missense_Mutation_p.E765Q			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	765						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				GCAGAAAGAGGAGCCCATCCC	0.652000													3	1					0	0	0.004672	0	0
TRPA1	8989	broad.mit.edu	37	8	72973926	72973926	+	Nonsense_Mutation	SNP	G	G	T	rs141174965		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:72973926G>T	ENST00000262209.4	-	7	1085	c.878C>A	c.(877-879)tCg>tAg	p.S293*		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	293						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AGAATAGGACGATATCATCAG	0.428000													36	45					1.56738e-10	2.08491e-10	0.019004	1	0
GRID1	2894	broad.mit.edu	37	10	87628808	87628808	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:87628808G>T	ENST00000327946.7	-	6	995	c.910C>A	c.(910-912)Ctg>Atg	p.L304M		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	304						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.L304M(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCGCAGAGCAGGGAGGAGATG	0.577000										Multiple Myeloma(13;0.14)			31	57					8.4185e-14	1.23219e-13	0.050027	1	0
NPL	80896	broad.mit.edu	37	1	182785877	182785877	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:182785877G>T	ENST00000367554.3	+	6	654	c.336G>T	c.(334-336)gtG>gtT	p.V112V	NPL_ENST00000367552.2_Silent_p.V131V|NPL_ENST00000258317.2_Silent_p.V131V|NPL_ENST00000367555.1_Silent_p.V131V|NPL_ENST00000463899.1_3'UTR|NPL_ENST00000367553.1_Silent_p.V131V	NM_001200050.1	NP_001186979.1	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	131					carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(1)|stomach(1)	15						TAAAGGAAGTGGCTGCTGCCG	0.428000													10	8					0.000978159	0.00105283	0.010729	1	0
INPP4A	3631	broad.mit.edu	37	2	99180085	99180085	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:99180085G>T	ENST00000074304.5	+	19	2421	c.2028G>T	c.(2026-2028)gtG>gtT	p.V676V	INPP4A_ENST00000409540.3_Silent_p.V637V|INPP4A_ENST00000545415.1_Silent_p.V637V|INPP4A_ENST00000523221.1_Silent_p.V676V|INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000409851.3_Silent_p.V671V|INPP4A_ENST00000409016.3_Silent_p.V637V	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	676					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						GCCGTGACGTGGTCTTCTGCC	0.607000													6	2					2.17888e-05	2.46435e-05	0.058154	1	0
USP13	8975	broad.mit.edu	37	3	179481954	179481954	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:179481954A>T	ENST00000263966.3	+	18	2728	c.2257A>T	c.(2257-2259)Acg>Tcg	p.T753S	USP13_ENST00000496897.1_Missense_Mutation_p.T688S	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	753	UBA 2.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			ACTACGAGCAACGGTGAGCAT	0.448000													23	38					0	0	0.024334	0	0
RAB22A	57403	broad.mit.edu	37	20	56929224	56929224	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:56929224G>T	ENST00000244040.3	+	6	671	c.390G>T	c.(388-390)gaG>gaT	p.E130D		NM_020673.2	NP_065724.1	Q9UL26	RB22A_HUMAN	RAB22A, member RAS oncogene family	130					endocytosis|endosome organization|protein transport|small GTPase mediated signal transduction	early endosome|endosome membrane|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|pancreas(1)	6	all_epithelial(3;5.09e-14)|Lung NSC(12;0.000122)|all_lung(29;0.00042)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;4.73e-08)|all cancers(14;4.83e-07)			AAGTCATGGAGAGAGATGCAA	0.393000													12	18					2.31682e-05	2.61338e-05	0.024245	1	0
SGCD	6444	broad.mit.edu	37	5	155771558	155771558	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:155771558G>A	ENST00000435422.3	+	2	547	c.60G>A	c.(58-60)caG>caA	p.Q20Q	SGCD_ENST00000337851.4_Silent_p.Q21Q|SGCD_ENST00000447401.1_Silent_p.Q21Q|SGCD_ENST00000517913.1_Silent_p.Q21Q	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	20					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGGGCCACAGGTATACAAGG	0.498000													36	36					0	0	0.033182	0	0
OR4C46	119749	broad.mit.edu	37	11	51515365	51515365	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:51515365G>T	ENST00000328188.1	+	1	84	c.84G>T	c.(82-84)gtG>gtT	p.V28V		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						TATTTGTTGTGTTTTTTGTCA	0.428000													65	68					5.00936e-31	8.97863e-31	0.048971	1	0
SPOCK3	50859	broad.mit.edu	37	4	167810365	167810365	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:167810365C>T	ENST00000357154.3	-	7	651	c.514G>A	c.(514-516)Gga>Aga	p.G172R	SPOCK3_ENST00000512681.1_Missense_Mutation_p.G74R|SPOCK3_ENST00000506886.1_Missense_Mutation_p.G172R|SPOCK3_ENST00000511269.1_Missense_Mutation_p.G169R|SPOCK3_ENST00000421836.2_Missense_Mutation_p.G121R|SPOCK3_ENST00000511531.1_Missense_Mutation_p.G172R|SPOCK3_ENST00000504953.1_Missense_Mutation_p.G169R|SPOCK3_ENST00000541637.1_Missense_Mutation_p.G74R|SPOCK3_ENST00000541354.1_Missense_Mutation_p.G52R|SPOCK3_ENST00000535728.1_Missense_Mutation_p.G80R|SPOCK3_ENST00000502330.1_Missense_Mutation_p.G172R|SPOCK3_ENST00000534949.1_Missense_Mutation_p.G76R|SPOCK3_ENST00000510741.1_Missense_Mutation_p.G169R|SPOCK3_ENST00000357545.4_Missense_Mutation_p.G169R|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000512648.1_Missense_Mutation_p.G169R	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	172	Kazal-like.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		ATCTGTTTTCCTAAGACACAT	0.328000													32	47					0	0	0.050027	0	0
KALRN	8997	broad.mit.edu	37	3	124351421	124351421	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:124351421G>T	ENST00000360013.3	+	35	5458	c.5331G>T	c.(5329-5331)cgG>cgT	p.R1777R	KALRN_ENST00000428018.2_Silent_p.R80R|KALRN_ENST00000291478.4_Silent_p.R80R|KALRN_ENST00000393496.1_Silent_p.R150R	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1777					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTGTGCGTCGGCTTAACAGCG	0.562000													19	23					0.000132079	0.000145493	0.049695	1	0
TMEM132B	114795	broad.mit.edu	37	12	126135489	126135489	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:126135489C>T	ENST00000299308.3	+	7	1897	c.1889C>T	c.(1888-1890)aCc>aTc	p.T630I	TMEM132B_ENST00000535886.1_Missense_Mutation_p.T142I	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	630						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCGGGAATAACCACGGTGCAG	0.567000													20	26					0	0	0.016522	0	0
OR8J1	219477	broad.mit.edu	37	11	56128532	56128532	+	Silent	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:56128532T>A	ENST00000303039.3	+	1	842	c.810T>A	c.(808-810)acT>acA	p.T270T		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T270T(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					CACTGGATACTGATGATAAGA	0.418000													56	8					0	0	0.048971	0	0
MCOLN3	55283	broad.mit.edu	37	1	85488055	85488055	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:85488055A>G	ENST00000370589.2	-	10	1176	c.1124T>C	c.(1123-1125)aTa>aCa	p.I375T	MCOLN3_ENST00000341115.4_Missense_Mutation_p.I319T|WDR63_ENST00000370596.1_Intron|MCOLN3_ENST00000474447.1_5'UTR	NM_018298.10	NP_060768.8	Q8TDD5	MCLN3_HUMAN	mucolipin 3	375						integral to membrane	ion channel activity			endometrium(6)|kidney(3)|large_intestine(9)|lung(12)|prostate(3)|skin(1)	34				all cancers(265;0.00957)|Epithelial(280;0.0254)		CCCAAGAAGTATGCTACAGAC	0.388000													10	12					0	0	0.016723	0	0
MARCH11	441061	broad.mit.edu	37	5	16177940	16177940	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:16177940A>C	ENST00000332432.8	-	2	787	c.588T>G	c.(586-588)caT>caG	p.H196Q	MARCH11_ENST00000505509.1_5'UTR	NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	196						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						GGCACAGCTGATGTGTATACC	0.418000													6	98					0	0	0.038147	0	0
SORCS1	114815	broad.mit.edu	37	10	108377961	108377961	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:108377961G>C	ENST00000263054.6	-	21	2873	c.2866C>G	c.(2866-2868)Cag>Gag	p.Q956E	SORCS1_ENST00000369698.1_Missense_Mutation_p.Q491E|SORCS1_ENST00000344440.6_Missense_Mutation_p.Q956E|SORCS1_ENST00000478809.2_5'UTR	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	956						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCTGAGACCTGCACTGTGATG	0.468000													43	54					0	0	0.048971	0	0
OR8H1	219469	broad.mit.edu	37	11	56058177	56058177	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:56058177C>A	ENST00000313022.2	-	1	389	c.362G>T	c.(361-363)cGc>cTc	p.R121L		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					AGCTACGTAGCGATCATAGGC	0.443000													74	11					8.73484e-25	1.52051e-24	0.048971	1	0
NUTM1	256646	broad.mit.edu	37	15	34648891	34648891	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:34648891C>A	ENST00000537011.1	+	8	3064	c.2682C>A	c.(2680-2682)ctC>ctA	p.L894L	NUTM1_ENST00000438749.3_Silent_p.L884L|NUTM1_ENST00000333756.4_Silent_p.L866L					NUT midline carcinoma, family member 1																		AAGGCAATCTCCTTATCATGG	0.517000													36	39					1.60099e-16	2.50821e-16	0.021022	1	0
TLR4	7099	broad.mit.edu	37	9	120474728	120474728	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:120474728A>G	ENST00000355622.6	+	3	423	c.322A>G	c.(322-324)Ata>Gta	p.I108V	TLR4_ENST00000394487.4_Missense_Mutation_p.I68V|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	108					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTCTACCTTAATATTGACAGG	0.423000													24	37					0	0	0.030593	0	0
EXOC2	55770	broad.mit.edu	37	6	497487	497487	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:497487C>T	ENST00000230449.4	-	25	2574	c.2439G>A	c.(2437-2439)gtG>gtA	p.V813V	EXOC2_ENST00000448181.3_Silent_p.V408V	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	813					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AAATGGTGAACACCTGGTTTG	0.393000													51	81					0	0	0.048971	0	0
RFT1	91869	broad.mit.edu	37	3	53156498	53156498	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:53156498G>A	ENST00000296292.3	-	4	409	c.348C>T	c.(346-348)gtC>gtT	p.V116V	RFT1_ENST00000394738.3_Silent_p.V77V	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	116					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		CATAGTGAGGGACAACATTAG	0.502000													19	38					0	0	0.049695	0	0
NPL	80896	broad.mit.edu	37	1	182785878	182785878	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:182785878G>C	ENST00000367554.3	+	6	655	c.337G>C	c.(337-339)Gct>Cct	p.A113P	NPL_ENST00000367552.2_Missense_Mutation_p.A132P|NPL_ENST00000258317.2_Missense_Mutation_p.A132P|NPL_ENST00000367555.1_Missense_Mutation_p.A132P|NPL_ENST00000463899.1_3'UTR|NPL_ENST00000367553.1_Missense_Mutation_p.A132P	NM_001200050.1	NP_001186979.1	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	132					carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(1)|stomach(1)	15						AAAGGAAGTGGCTGCTGCCGC	0.428000													10	8					0	0	0.010729	0	0
LAMA2	3908	broad.mit.edu	37	6	129785486	129785486	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:129785486T>A	ENST00000421865.2	+	50	7093	c.7044T>A	c.(7042-7044)taT>taA	p.Y2348*		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2348	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGAAGGTTATGCATTGGTCA	0.438000													27	39					0	0	0.034045	0	0
RNF38	152006	broad.mit.edu	37	9	36356416	36356416	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:36356416G>A	ENST00000357058.3	-	6	1150	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S	RNF38_ENST00000259605.6_Missense_Mutation_p.P265S|RNF38_ENST00000350199.4_Missense_Mutation_p.P182S|RNF38_ENST00000377877.4_Missense_Mutation_p.P189S|RNF38_ENST00000353739.4_Missense_Mutation_p.P215S|RNF38_ENST00000377885.2_Missense_Mutation_p.P182S|RNF38_ENST00000491349.1_5'UTR	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	265							zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			GAAATAAGGGGTGGGAATGCA	0.423000													17	44					0	0	0.062417	0	0
MROH2B	133558	broad.mit.edu	37	5	41010047	41010047	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:41010047T>G	ENST00000399564.4	-	31	3720	c.3270A>C	c.(3268-3270)ttA>ttC	p.L1090F	MROH2B_ENST00000506092.2_Missense_Mutation_p.L645F	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GAGGCTTCTGTAAAAGGTTGA	0.448000													41	144					0	0	0.036044	0	0
PSORS1C2	170680	broad.mit.edu	37	6	31105978	31105978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:31105978C>T	ENST00000259845.4	-	2	484	c.161G>A	c.(160-162)tGg>tAg	p.W54*	PSORS1C1_ENST00000547221.1_Intron|PSORS1C1_ENST00000259881.9_Intron	NM_014069.2	NP_054788.2	Q9UIG4	PS1C2_HUMAN	psoriasis susceptibility 1 candidate 2	54						extracellular region				NS(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TGCCCCTGGCCAAGGGTCACC	0.677000													27	16					0	0	0.030593	0	0
DPP10	57628	broad.mit.edu	37	2	116572433	116572433	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:116572433A>T	ENST00000410059.1	+	20	2245	c.1765A>T	c.(1765-1767)Att>Ttt	p.I589F	DPP10_ENST00000409163.1_Missense_Mutation_p.I539F|DPP10_ENST00000310323.8_Missense_Mutation_p.I582F|DPP10_ENST00000393147.2_Missense_Mutation_p.I593F	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	589					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TTCCGTACTCATTGACATGGA	0.423000													44	20					0	0	0.048971	0	0
NTNG2	84628	broad.mit.edu	37	9	135073796	135073796	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:135073796C>A	ENST00000393229.3	+	3	1433	c.657C>A	c.(655-657)ttC>ttA	p.F219L	NTNG2_ENST00000360670.3_Missense_Mutation_p.F219L|NTNG2_ENST00000393228.4_Missense_Mutation_p.F219L|NTNG2_ENST00000372179.3_Missense_Mutation_p.F219L	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	219	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GGGACCGCTTCGCCATCTTTG	0.657000													9	12					7.48243e-07	8.89064e-07	0.058154	1	0
TEX15	56154	broad.mit.edu	37	8	30699628	30699628	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:30699628G>T	ENST00000256246.2	-	1	6980	c.6906C>A	c.(6904-6906)aaC>aaA	p.N2302K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2302										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGATGTTTTTGTTTATGCACT	0.338000													15	14					7.93312e-07	9.34738e-07	0.020292	1	0
PCDHB5	26167	broad.mit.edu	37	5	140515335	140515335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:140515335C>T	ENST00000231134.5	+	1	536	c.319C>T	c.(319-321)Cag>Tag	p.Q107*		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		107	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTGCATTTCCAGCTCTTACT	0.448000													34	39					0	0	0.059317	0	0
SPEN	23013	broad.mit.edu	37	1	16255645	16255645	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:16255645A>T	ENST00000375759.3	+	11	3114	c.2910A>T	c.(2908-2910)gcA>gcT	p.A970A		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	970			A -> V (in dbSNP:rs848208).		interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGCAGCCTGCAGATGGGGTAA	0.488000													44	29					0	0	0.045515	0	0
NUSAP1	51203	broad.mit.edu	37	15	41667974	41667974	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:41667974G>A	ENST00000260359.6	+	9	1290	c.1026G>A	c.(1024-1026)gtG>gtA	p.V342V	NUSAP1_ENST00000559596.1_Silent_p.V357V|NUSAP1_ENST00000560747.1_Silent_p.V355V|NUSAP1_ENST00000450318.1_Intron|NUSAP1_ENST00000450592.2_Intron|NUSAP1_ENST00000414849.2_Silent_p.V356V|NUSAP1_ENST00000560177.1_Silent_p.V356V|NUSAP1_ENST00000558123.1_Intron	NM_001243142.1|NM_001243143.1|NM_016359.4|NM_018454.7	NP_001230071.1|NP_001230072.1|NP_057443.2|NP_060924.4	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	357	Interaction with microtubules (By similarity).				cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	13		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		AGAAACCAGTGTTTGATCTTA	0.403000													11	29					0	0	0.016723	0	0
NEK7	140609	broad.mit.edu	37	1	198225544	198225544	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:198225544A>T	ENST00000367383.1	+	4	469	c.285A>T	c.(283-285)ctA>ctT	p.L95L	NEK7_ENST00000367385.4_Intron|NEK7_ENST00000538004.1_Intron			Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	95	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						CTGAGAGCCTACAGTATATGG	0.363000													19	48					0	0	0.049695	0	0
DAB1	1600	broad.mit.edu	37	1	57756695	57756695	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:57756695G>C	ENST00000371236.2	-	2	271	c.8C>G	c.(7-9)aCt>aGt	p.T3S	DAB1_ENST00000371231.1_Missense_Mutation_p.T3S|DAB1_ENST00000371234.4_Missense_Mutation_p.T3S|DAB1_ENST00000371230.1_Missense_Mutation_p.T3S|DAB1_ENST00000414851.2_Missense_Mutation_p.T3S|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000420954.2_Missense_Mutation_p.T3S|DAB1_ENST00000439789.2_Missense_Mutation_p.T3S			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	3					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TTCTGTCTCAGTTGACATCCT	0.463000													42	37					0	0	0.039052	0	0
ODF1	4956	broad.mit.edu	37	8	103572954	103572954	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:103572954G>T	ENST00000285402.3	+	2	751	c.595G>T	c.(595-597)Gag>Tag	p.E199*	ODF1_ENST00000518835.1_Intron	NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	199					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			TGTCAAGATCGAGTCTCCTTG	0.572000													5	17					0.014758	0.0153382	0.014758	1	0
PIGR	5284	broad.mit.edu	37	1	207109005	207109005	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:207109005C>A	ENST00000356495.4	-	5	1387	c.1204G>T	c.(1204-1206)Gag>Tag	p.E402*		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	402	Ig-like V-type 4.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						ACCCACCCCTCGCTGTCCACC	0.627000											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	9					4.68919e-08	5.65107e-08	0.008291	1	0
DGKI	9162	broad.mit.edu	37	7	137374668	137374668	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:137374668T>C	ENST00000424189.2	-	2	711	c.482A>G	c.(481-483)aAg>aGg	p.K161R	DGKI_ENST00000288490.5_Missense_Mutation_p.K161R|DGKI_ENST00000453654.1_Intron|DGKI_ENST00000446122.1_Missense_Mutation_p.K161R			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	161					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						TCTGGGCTCCTTGGCTGGACC	0.512000													6	17					0	0	0.038147	0	0
PCSK6	5046	broad.mit.edu	37	15	101971605	101971605	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:101971605C>A	ENST00000348070.1	-	5	573	c.574G>T	c.(574-576)Ggc>Tgc	p.G192C	PCSK6_ENST00000344273.2_Missense_Mutation_p.G192C|PCSK6_ENST00000398181.2_Missense_Mutation_p.G192C|PCSK6_ENST00000331826.7_Missense_Mutation_p.G27C|PCSK6_ENST00000358417.3_Missense_Mutation_p.G192C|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	193	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCTGTGTAGCCCCTCTTCCAC	0.517000													13	20					4.75885e-15	7.26712e-15	0.033300	1	0
C4orf21	55345	broad.mit.edu	37	4	113510861	113510861	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:113510861G>A	ENST00000309071.5	-	11	3271	c.3146C>T	c.(3145-3147)gCt>gTt	p.A1049V	C4orf21_ENST00000505019.1_Intron			Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	1049										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AGATATTAGAGCAATGTGGTA	0.353000													28	52					0	0	0.034045	0	0
LAMC2	3918	broad.mit.edu	37	1	183204723	183204723	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:183204723G>T	ENST00000264144.4	+	16	2379	c.2314G>T	c.(2314-2316)Gcc>Tcc	p.A772S	LAMC2_ENST00000493293.1_Missense_Mutation_p.A772S	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	772	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CGTTGAGTCAGCCAGTAACAT	0.478000											OREG0014042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	27					0.000151284	0.000166216	0.016723	1	0
TBC1D32	221322	broad.mit.edu	37	6	121434319	121434319	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:121434319C>A	ENST00000275159.6	-	29	3180	c.3181G>T	c.(3181-3183)Ggc>Tgc	p.G1061C	TBC1D32_ENST00000398212.2_Missense_Mutation_p.G1020C|TBC1D32_ENST00000398197.2_5'UTR					TBC1 domain family, member 32																		AGGAATTTGCCATACCTATAT	0.333000													10	26					0.00621372	0.006571	0.058154	1	0
NPAP1	23742	broad.mit.edu	37	15	24922227	24922227	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:24922227G>T	ENST00000329468.2	+	1	1687	c.1213G>T	c.(1213-1215)Gtg>Ttg	p.V405L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTCCCAACCTGTGCAGACCAC	0.537000													20	46					3.5997e-14	5.34271e-14	0.014323	1	0
PLA2G2F	64600	broad.mit.edu	37	1	20466690	20466690	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:20466690G>T	ENST00000375102.3	+	2	250	c.148G>T	c.(148-150)Gtg>Ttg	p.V50L		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	7					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity	p.V50L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GTTCTTCACCGTGGCCATCCT	0.592000													21	23					9.57634e-11	1.2819e-10	0.018920	1	0
WHSC1	7468	broad.mit.edu	37	4	1954929	1954929	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:1954929C>T	ENST00000382888.3	+	2	578	c.60C>T	c.(58-60)gcC>gcT	p.A20A	WHSC1_ENST00000508803.1_Intron|WHSC1_ENST00000382891.5_Intron|WHSC1_ENST00000382895.3_Intron|WHSC1_ENST00000382892.2_Intron|WHSC1_ENST00000482415.2_Intron			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	0					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAACAGGGCCAGGTGCTTTA	0.488000			T	IGH@	MM								7	3					0	0	0.029380	0	0
UNC13C	440279	broad.mit.edu	37	15	54307916	54307916	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:54307916A>G	ENST00000545554.1	+	1	2816	c.2816A>G	c.(2815-2817)aAt>aGt	p.N939S	UNC13C_ENST00000260323.11_Missense_Mutation_p.N939S|UNC13C_ENST00000537900.1_Missense_Mutation_p.N939S			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	939					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAACCCTTAAATGAAACATCA	0.408000													17	41					0	0	0.028581	0	0
CNKSR2	22866	broad.mit.edu	37	X	21609190	21609190	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:21609190C>A	ENST00000425654.2	+	14	2098	c.1618C>A	c.(1618-1620)Cgt>Agt	p.R540S	CNKSR2_ENST00000379510.3_Missense_Mutation_p.R570S|CNKSR2_ENST00000279451.4_Missense_Mutation_p.R570S|CNKSR2_ENST00000485012.1_3'UTR|CNKSR2_ENST00000543067.1_Missense_Mutation_p.R521S	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	570					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AGATCTTGGCCGTGGTGACTG	0.408000													96	13					1.9358e-47	3.60724e-47	0.048971	1	0
NSD1	64324	broad.mit.edu	37	5	176638954	176638954	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:176638954G>T	ENST00000439151.2	+	5	3599	c.3554G>T	c.(3553-3555)tGt>tTt	p.C1185F	NSD1_ENST00000347982.4_Missense_Mutation_p.C916F|NSD1_ENST00000354179.4_Missense_Mutation_p.C916F|NSD1_ENST00000361032.4_Missense_Mutation_p.C1082F	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1185					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AACTCTGAGTGTGCCTTTAGG	0.478000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			28	56					3.1745e-13	4.5519e-13	0.037714	1	0
LAMB4	22798	broad.mit.edu	37	7	107746440	107746440	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:107746440G>T	ENST00000388781.3	-	8	775	c.692C>A	c.(691-693)aCc>aAc	p.T231N	LAMB4_ENST00000414450.2_Missense_Mutation_p.T231N|LAMB4_ENST00000388780.3_Missense_Mutation_p.T231N|LAMB4_ENST00000205386.4_Missense_Mutation_p.T231N	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	231	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GTGGAGCTTGGTAAAGTTTAT	0.413000													28	37					1.16021e-09	1.46937e-09	0.034045	1	0
PRMT10	90826	broad.mit.edu	37	4	148601524	148601524	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:148601524C>A	ENST00000322396.6	-	2	530	c.288G>T	c.(286-288)ctG>ctT	p.L96L	PRMT10_ENST00000541232.1_Intron	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	96						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						CATCAGGAAACAGTTCCAAGG	0.393000													22	34					1.10923e-09	1.40902e-09	0.016522	1	0
PMS1	5378	broad.mit.edu	37	2	190742055	190742055	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:190742055C>G	ENST00000441310.2	+	13	2925	c.2692C>G	c.(2692-2694)Caa>Gaa	p.Q898E	PMS1_ENST00000432292.3_Missense_Mutation_p.Q722E|PMS1_ENST00000447232.2_Missense_Mutation_p.Q736E|PMS1_ENST00000418224.3_Missense_Mutation_p.Q722E|PMS1_ENST00000409823.3_Missense_Mutation_p.Q859E	NM_000534.4	NP_000525.1	P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	898					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AGAGGACATCCAAGACATTAT	0.393000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					12	41					0	0	0.016723	0	0
SPATS1	221409	broad.mit.edu	37	6	44329629	44329629	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:44329629C>T	ENST00000288390.2	+	4	821	c.474C>T	c.(472-474)taC>taT	p.Y158Y	SPATS1_ENST00000323108.8_Silent_p.Y158Y			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	158										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCACACCTACCACGTCGGAA	0.488000													54	70					0	0	0.048971	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81444712	81444712	+	RNA	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:81444712C>T	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							GTGCAAGGTCCACGTGCTGGC	0.577000													8	6					0	0	0.047766	0	0
NETO1	81832	broad.mit.edu	37	18	70417314	70417314	+	Silent	SNP	G	G	A	rs144601570	byFrequency	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:70417314G>A	ENST00000327305.6	-	9	2181	c.1524C>T	c.(1522-1524)caC>caT	p.H508H	NETO1_ENST00000583169.1_Silent_p.H508H|NETO1_ENST00000299430.2_Silent_p.H507H	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	508					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CGGCTTTATCGTGTCTGGACA	0.438000													14	62					0	0	0.028581	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454840	84454840	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr13:84454840T>A	ENST00000377084.2	-	1	1688	c.803A>T	c.(802-804)gAt>gTt	p.D268V		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	268						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAGACTAGAATCCACTCGGTT	0.557000													7	5					0	0	0.029380	0	0
PSAPL1	768239	broad.mit.edu	37	4	7435644	7435644	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:7435644C>T	ENST00000319098.4	-	1	1056	c.963G>A	c.(961-963)ctG>ctA	p.L321L	SORCS2_ENST00000507866.2_Intron|SORCS2_ENST00000329016.9_Intron|SORCS2_ENST00000511199.1_Intron	NM_001085382.1	NP_001078851.1	Q6NUJ1	SAPL1_HUMAN	prosaposin-like 1 (gene/pseudogene)	321	Saposin B-type 3.				sphingolipid metabolic process	extracellular region|lysosome				lung(4)	4						ACACGCGCTCCAGGGCATGGG	0.567000													15	32					0	0	0.055883	0	0
MGST3	4259	broad.mit.edu	37	1	165623519	165623519	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:165623519A>T	ENST00000367889.3	+	5	693	c.253A>T	c.(253-255)Ata>Tta	p.I85L	MGST3_ENST00000404549.1_Missense_Mutation_p.I99L|MGST3_ENST00000367885.1_Missense_Mutation_p.I99L|MGST3_ENST00000367888.4_Missense_Mutation_p.I85L|MGST3_ENST00000367886.2_Missense_Mutation_p.I99L|MGST3_ENST00000367883.1_Missense_Mutation_p.I99L|MGST3_ENST00000367884.1_Missense_Mutation_p.I85L	NM_004528.3	NP_004519.1	O14880	MGST3_HUMAN	microsomal glutathione S-transferase 3	85					leukotriene biosynthetic process|leukotriene production involved in inflammatory response|signal transduction|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glutathione peroxidase activity|glutathione transferase activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	6	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Glutathione(DB00143)	TTCTTAGCGTATAGCTTCTGG	0.383000													29	49					0	0	0.045705	0	0
FRYL	285527	broad.mit.edu	37	4	48622683	48622683	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:48622683C>T	ENST00000358350.4	-	6	891	c.287G>A	c.(286-288)aGg>aAg	p.R96K	FRYL_ENST00000503238.1_Missense_Mutation_p.R96K|FRYL_ENST00000507711.1_Missense_Mutation_p.R96K|FRYL_ENST00000537810.1_Missense_Mutation_p.R96K|FRYL_ENST00000264319.7_5'UTR	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGACCGAGGCCTATATTCATA	0.428000													46	63					0	0	0.048971	0	0
FAM179A	165186	broad.mit.edu	37	2	29222072	29222072	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:29222072C>T	ENST00000379558.4	+	4	516	c.165C>T	c.(163-165)gcC>gcT	p.A55A	FAM179A_ENST00000403861.2_Silent_p.A55A	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	55			A -> T (in dbSNP:rs13009279).				binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGCCAAGAGCCCTGCTGAACA	0.622000													16	60					0	0	0.043863	0	0
HGF	3082	broad.mit.edu	37	7	81346574	81346574	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:81346574G>T	ENST00000222390.5	-	11	1605	c.1379C>A	c.(1378-1380)cCt>cAt	p.P460H	HGF_ENST00000457544.2_Missense_Mutation_p.P455H	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	460	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						ATAATCCCAAGGAATGAGTGG	0.388000													48	73					2.79147e-13	4.03e-13	0.048971	1	0
SIGLEC6	946	broad.mit.edu	37	19	52033171	52033171	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:52033171G>T	ENST00000346477.3	-	4	839	c.771C>A	c.(769-771)ctC>ctA	p.L257L	SIGLEC6_ENST00000343300.4_Silent_p.L273L|SIGLEC6_ENST00000391797.3_Silent_p.L262L|SIGLEC6_ENST00000436458.1_Silent_p.L221L|SIGLEC6_ENST00000425629.3_Silent_p.L273L|SIGLEC6_ENST00000359982.4_Silent_p.L284L	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	273	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CAGCATCACAGAGCAGCCGCA	0.622000													18	6					2.70639e-06	3.16244e-06	0.014323	1	0
FOXL2	668	broad.mit.edu	37	3	138664519	138664519	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:138664519C>A	ENST00000330315.3	-	1	1463	c.1046G>T	c.(1045-1047)cGg>cTg	p.R349L		NM_023067.3	NP_075555.1	P58012	FOXL2_HUMAN	forkhead box L2	349					convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			large_intestine(1)|lung(1)|ovary(333)|skin(1)	336						CTCGGGCTGCCGGGCACAAGC	0.736000			Mis		granulosa-cell tumour of the ovary		"""Blepharophimosis, ptosis and epicanthus inversus Types I, II; Premature ovarian failure type III"""						7	7					0.000157383	0.000172024	0.038147	1	0
CCDC132	55610	broad.mit.edu	37	7	92952939	92952939	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:92952939G>T	ENST00000544910.1	+	22	2002	c.1782G>T	c.(1780-1782)atG>atT	p.M594I	CCDC132_ENST00000535481.1_Missense_Mutation_p.M344I|CCDC132_ENST00000541136.1_Missense_Mutation_p.M435I|CCDC132_ENST00000305866.5_Missense_Mutation_p.M624I	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	624										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ATATGCAGATGATGAACATTC	0.239000													8	22					5.18039e-06	5.95463e-06	0.038147	1	0
CHMP2B	25978	broad.mit.edu	37	3	87295012	87295012	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:87295012T>A	ENST00000263780.4	+	3	513	c.275T>A	c.(274-276)aTg>aAg	p.M92K	CHMP2B_ENST00000472024.1_3'UTR|CHMP2B_ENST00000494980.1_Intron|CHMP2B_ENST00000471660.1_Missense_Mutation_p.M51K	NM_014043.3	NP_054762.2	Q9UQN3	CHM2B_HUMAN	charged multivesicular body protein 2B	92					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	12	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ACAAAAGTGATGAATTCCCAA	0.323000													25	30					0	0	0.034045	0	0
GPR139	124274	broad.mit.edu	37	16	20043969	20043969	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:20043969G>T	ENST00000570682.1	-	2	450	c.150C>A	c.(148-150)atC>atA	p.I50I		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	50						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GCTGGGAGAGGATGATCACTG	0.483000													16	24					5.01169e-05	5.59353e-05	0.033300	1	0
KCNC2	3747	broad.mit.edu	37	12	75601343	75601343	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:75601343A>T	ENST00000549446.1	-	2	1101	c.421T>A	c.(421-423)Tgg>Agg	p.W141R	KCNC2_ENST00000548513.1_Missense_Mutation_p.W141R|KCNC2_ENST00000550433.1_Missense_Mutation_p.W141R|KCNC2_ENST00000298972.1_Missense_Mutation_p.W141R|KCNC2_ENST00000393288.2_Missense_Mutation_p.W141R|KCNC2_ENST00000540018.1_Missense_Mutation_p.W141R|KCNC2_ENST00000350228.2_Missense_Mutation_p.W141R|KCNC2_ENST00000341669.3_Missense_Mutation_p.W141R	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	141					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						TCGATGCCCCAGAAGGCCAGC	0.672000													33	25					0	0	0.021022	0	0
METTL7A	25840	broad.mit.edu	37	12	51319244	51319244	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:51319244G>A	ENST00000548553.1	+	2	1404	c.423G>A	c.(421-423)gtG>gtA	p.V141V	METTL7A_ENST00000332160.4_Silent_p.V141V			Q9H8H3	MET7A_HUMAN	methyltransferase like 7A	141						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	10						TGGATGTGGTGGTCTGCACCC	0.582000													15	39					0	0	0.033300	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39564954	39564954	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:39564954C>A	ENST00000432258.1	+	0	368				AC003958.2_ENST00000430006.1_RNA																							CCAGGTCACACTTGGCGAGGG	0.582000													7	12					7.48243e-07	8.89064e-07	0.058154	1	0
SLC38A9	153129	broad.mit.edu	37	5	54960566	54960566	+	Missense_Mutation	SNP	C	C	T	rs141328492		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:54960566C>T	ENST00000539768.1	-	6	651	c.652G>A	c.(652-654)Gtg>Atg	p.V218M	SLC38A9_ENST00000318672.3_Missense_Mutation_p.V218M|SLC38A9_ENST00000416547.2_Missense_Mutation_p.V94M|SLC38A9_ENST00000396865.2_Missense_Mutation_p.V218M|SLC38A9_ENST00000512595.1_Missense_Mutation_p.V191M|SLC38A9_ENST00000515629.1_Missense_Mutation_p.V155M			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	218					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GACATAAGCACCCAATAAACT	0.348000													18	26					0	0	0.055883	0	0
NAV3	89795	broad.mit.edu	37	12	78513153	78513153	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:78513153G>A	ENST00000397909.2	+	15	3350	c.3177G>A	c.(3175-3177)tcG>tcA	p.S1059S	NAV3_ENST00000536525.2_Silent_p.S1059S|NAV3_ENST00000266692.7_Silent_p.S1059S|NAV3_ENST00000228327.6_Silent_p.S1059S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1059	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTGGAAGATCGACTGCCACCA	0.493000										HNSCC(70;0.22)			70	54					0	0	0.048971	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22786154	22786154	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:22786154C>A	ENST00000599738.1	+	0	84				CTC-457E21.3_ENST00000600260.1_RNA																							CTCAGGAGCGCCCAGGCTTGG	0.577000													6	7					1.12685e-05	1.28479e-05	0.047766	1	0
USP2-AS1	100499227	broad.mit.edu	37	11	119397184	119397184	+	RNA	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:119397184C>G	ENST00000500970.1	+	0	1594																											tcgagatcagcccagccaaca	0.517000													5	3					0	0	0.038147	0	0
ANK1	286	broad.mit.edu	37	8	41577349	41577349	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:41577349C>A	ENST00000396942.1	-	10	1020	c.937G>T	c.(937-939)Gct>Tct	p.A313S	ANK1_ENST00000352337.4_Missense_Mutation_p.A313S|ANK1_ENST00000347528.4_Missense_Mutation_p.A313S|ANK1_ENST00000379758.2_Missense_Mutation_p.A313S|ANK1_ENST00000265709.8_Missense_Mutation_p.A346S|ANK1_ENST00000289734.7_Missense_Mutation_p.A313S|ANK1_ENST00000396945.1_Missense_Mutation_p.A313S			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	313	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTCCCTGAGCCGCCATGTGA	0.562000													37	28					2.19489e-29	3.86849e-29	0.025465	1	0
PROP1	5626	broad.mit.edu	37	5	177421211	177421211	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:177421211G>A	ENST00000308304.2	-	2	546	c.238C>T	c.(238-240)Cag>Tag	p.Q80*		NM_006261.4	NP_006252.3	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	80					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(9)|stomach(1)	13	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTTCCAACTGCACTGGGCTG	0.667000													89	78					0	0	0.048971	0	0
DCAF7	10238	broad.mit.edu	37	17	61628127	61628127	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:61628127A>G	ENST00000310827.4	+	1	306	c.89A>G	c.(88-90)aAg>aGg	p.K30R	DCAF7_ENST00000431926.1_Missense_Mutation_p.K30R|DCAF7_ENST00000577702.1_3'UTR|DCAF7_ENST00000415273.2_Missense_Mutation_p.K30R	NM_005828.3	NP_005819.3	P61962	DCAF7_HUMAN	DDB1 and CUL4 associated factor 7	30					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	18						CGGCCCGATAAGCGCTTTCGC	0.647000													4	9					0	0	0.009096	0	0
SPAG17	200162	broad.mit.edu	37	1	118530785	118530785	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:118530785G>T	ENST00000336338.5	-	39	5629	c.5564C>A	c.(5563-5565)aCg>aAg	p.T1855K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1855						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTTGGAGGCGTAGCCAAAGA	0.363000													13	11					2.61681e-11	3.57069e-11	0.020292	1	0
OR2M2	391194	broad.mit.edu	37	1	248343503	248343503	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:248343503G>T	ENST00000359682.2	+	1	216	c.216G>T	c.(214-216)atG>atT	p.M72I		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	72				M -> K (in Ref. 2; AAK95101).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGACCTCATGCTCATCTGCA	0.498000													104	225					1.07394e-59	2.02803e-59	0.048971	1	0
SCN3A	6328	broad.mit.edu	37	2	165947591	165947591	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:165947591T>A	ENST00000360093.3	-	28	5563	c.5072A>T	c.(5071-5073)aAc>aTc	p.N1691I	SCN3A_ENST00000409101.3_Missense_Mutation_p.N1642I|SCN3A_ENST00000540861.1_Missense_Mutation_p.N174I|SCN3A_ENST00000283254.7_Missense_Mutation_p.N1691I|AC013463.2_ENST00000431341.1_RNA	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1691						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GGTCTCAAAGTTGAACATGTC	0.448000													70	86					0	0	0.048971	0	0
KLHL28	54813	broad.mit.edu	37	14	45400639	45400639	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:45400639C>A	ENST00000396128.4	-	4	1568	c.1449G>T	c.(1447-1449)gtG>gtT	p.V483V	KLHL28_ENST00000355081.2_Silent_p.V497V	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	483										breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GTCCACCCACCACAAAAATAA	0.438000													22	16					2.50493e-22	4.27252e-22	0.024334	1	0
MLIP	90523	broad.mit.edu	37	6	53989530	53989530	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:53989530G>T	ENST00000514921.1	+	3	592	c.479G>T	c.(478-480)cGg>cTg	p.R160L	MLIP_ENST00000358276.5_Missense_Mutation_p.R154L|MLIP_ENST00000370876.2_Missense_Mutation_p.R98L|MLIP_ENST00000370877.2_Missense_Mutation_p.R108L|MLIP_ENST00000509997.1_Missense_Mutation_p.R108L|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000502396.1_Missense_Mutation_p.R171L|MLIP_ENST00000274897.5_Missense_Mutation_p.R160L			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	160						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						GCAGCTGTCCGGCCCAAGTCT	0.532000													35	52					1.90571e-15	2.93133e-15	0.019004	1	0
NINL	22981	broad.mit.edu	37	20	25456963	25456963	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:25456963C>A	ENST00000278886.6	-	17	3037	c.2964G>T	c.(2962-2964)agG>agT	p.R988S	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	988					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						CCTGGGTGCCCCTGCTCCAGC	0.687000													9	3					6.40141e-05	7.12578e-05	0.010729	1	0
POM121L12	285877	broad.mit.edu	37	7	53104135	53104135	+	Silent	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:53104135C>A	ENST00000408890.4	+	1	787	c.771C>A	c.(769-771)gtC>gtA	p.V257V		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	257										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCGTGCTGGTCCAGCCCGCCC	0.652000													60	34					4.10029e-35	7.50832e-35	0.048971	1	0
HIVEP3	59269	broad.mit.edu	37	1	42046898	42046898	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:42046898G>T	ENST00000372584.1	-	3	4585	c.3571C>A	c.(3571-3573)Ctt>Att	p.L1191I	HIVEP3_ENST00000372583.1_Missense_Mutation_p.L1191I|HIVEP3_ENST00000429157.2_Missense_Mutation_p.L1191I|HIVEP3_ENST00000247584.5_Missense_Mutation_p.L1191I	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1191					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGAGAGGAAGCGGTGGGGCT	0.592000													13	35					1.05317e-09	1.34589e-09	0.020292	1	0
CHRM2	1129	broad.mit.edu	37	7	136699885	136699885	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:136699885G>T	ENST00000445907.2	+	3	801	c.273G>T	c.(271-273)ttG>ttT	p.L91F	AC009264.1_ENST00000592183.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.L91F|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.L91F|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.L91F|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.L91F|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.L91F	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	91					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACTGGCCTTTGGGACCTGTGG	0.458000													49	75					1.22102e-19	2.0019e-19	0.048971	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766497	171766497	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:171766497C>A	ENST00000311601.5	-	13	1782	c.1612G>T	c.(1612-1614)Gag>Tag	p.E538*	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	538					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CGCTCCCGCTCCAGCAGCTCC	0.647000													11	20					6.72482e-11	9.05924e-11	0.024245	1	0
DNAH10	196385	broad.mit.edu	37	12	124265637	124265637	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:124265637C>T	ENST00000409039.3	+	6	474	c.449C>T	c.(448-450)cCa>cTa	p.P150L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	150	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GTTTTTTTGCCAGCATTGTCC	0.388000													64	90					0	0	0.048971	0	0
USP29	57663	broad.mit.edu	37	19	57641420	57641420	+	Silent	SNP	C	C	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:57641420C>T	ENST00000254181.4	+	4	1831	c.1377C>T	c.(1375-1377)caC>caT	p.H459H	USP29_ENST00000598197.1_Silent_p.H459H	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	459					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAACCTGCACCAAGAAACAA	0.358000													22	46					0	0	0.014323	0	0
LAMC1	3915	broad.mit.edu	37	1	183086517	183086517	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:183086517G>T	ENST00000258341.4	+	9	1884	c.1627G>T	c.(1627-1629)Gag>Tag	p.E543*		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	543	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGGTCCTCTGAGAGGCAAGA	0.512000													18	52					1.45105e-14	2.17658e-14	0.038395	1	0
MRPL9	65005	broad.mit.edu	37	1	151732528	151732528	+	Nonstop_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:151732528A>T	ENST00000368830.3	-	7	886	c.802T>A	c.(802-804)Taa>Aaa	p.*268K	MRPL9_ENST00000368829.3_Nonstop_Mutation_p.*234K|MRPL9_ENST00000467306.1_5'UTR	NM_031420.2	NP_113608.1	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9	0					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GAGTAGATTTAGATCTGGGGG	0.512000													13	9					0	0	0.020292	0	0
AC096579.13	0	broad.mit.edu	37	2	89160181	89160181	+	RNA	SNP	C	C	T	rs112994092	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:89160181C>T	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							ATATCACTAACCTGACCGATG	0.403000													8	23					0	0	0.038147	0	0
PXDNL	137902	broad.mit.edu	37	8	52323874	52323874	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:52323874C>A	ENST00000356297.4	-	16	2098	c.1998G>T	c.(1996-1998)gaG>gaT	p.E666D	PXDNL_ENST00000543296.1_Missense_Mutation_p.E666D	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	666					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCAGCGTGTGCTCAAAAATCT	0.517000													5	4					0.00198382	0.00212984	0.029380	1	0
MARC2	54996	broad.mit.edu	37	1	220935100	220935100	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:220935100G>T	ENST00000366913.3	+	3	745	c.547G>T	c.(547-549)Gag>Tag	p.E183*	MARC2_ENST00000359316.2_Nonsense_Mutation_p.E183*	NM_017898.3	NP_060368.2	Q969Z3	MOSC2_HUMAN	mitochondrial amidoxime reducing component 2	183						mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										GGTTCAATTTGAGACAAACAT	0.418000													24	40					1.1804e-14	1.7769e-14	0.021523	1	0
IL20RB	53833	broad.mit.edu	37	3	136729000	136729000	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:136729000G>T	ENST00000329582.4	+	7	1120	c.871G>T	c.(871-873)Gag>Tag	p.E291*	IL20RB_ENST00000309741.5_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	291						integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						CAGAAGGGAGGAGGTGGATGC	0.463000													46	64					5.18031e-10	6.70114e-10	0.048971	1	0
APPL1	26060	broad.mit.edu	37	3	57294181	57294181	+	Splice_Site	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:57294181G>T	ENST00000288266.3	+	18	1842	c.1695_splice	c.e18+1	p.T565_splice		NM_012096.2	NP_036228.1	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	565	PID.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(10)|liver(2)|lung(4)|prostate(2)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		CAAGGCTCACGGTGAGTTCCA	0.294000													7	25					0.000442599	0.000478822	0.058154	1	0
STIM1	6786	broad.mit.edu	37	11	4091385	4091385	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:4091385T>C	ENST00000300737.4	+	6	1312	c.743T>C	c.(742-744)tTg>tCg	p.L248S	STIM1_ENST00000533977.1_Missense_Mutation_p.L75S|STIM1_ENST00000527651.1_Missense_Mutation_p.L248S	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	248					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		ATGAAGGACTTGGAGGGGTTA	0.532000													35	30					0	0	0.033182	0	0
UTY	7404	broad.mit.edu	37	Y	15471024	15471024	+	Silent	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrY:15471024G>A	ENST00000382896.4	-	13	1263	c.1264C>T	c.(1264-1266)Cta>Tta	p.L422L	UTY_ENST00000329134.5_Intron|UTY_ENST00000545955.1_Silent_p.L422L|UTY_ENST00000540140.1_Intron|UTY_ENST00000538878.1_Intron|UTY_ENST00000537580.1_Silent_p.L422L|UTY_ENST00000362096.4_Intron|UTY_ENST00000331397.4_Intron	NM_001258252.1|NM_001258256.1	NP_001245181.1|NP_001245185.1	O14607	UTY_HUMAN	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	395					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(6)	7						GGGATTGGTAGGCTCCATGCC	0.453000													19	2					0	0	0.043863	0	0
LRRN2	10446	broad.mit.edu	37	1	204588041	204588041	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:204588041G>T	ENST00000367175.1	-	1	3292	c.1080C>A	c.(1078-1080)aaC>aaA	p.N360K	LRRN2_ENST00000367176.3_Missense_Mutation_p.N360K|LRRN2_ENST00000367177.3_Missense_Mutation_p.N360K			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	360					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CCTCCTGCAGGTTGGGCAGGG	0.637000													20	50					1.15919e-05	1.31811e-05	0.049695	1	0
NFATC1	4772	broad.mit.edu	37	18	77170932	77170932	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:77170932G>T	ENST00000253506.5	+	2	1026	c.657G>T	c.(655-657)gaG>gaT	p.E219D	NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000587635.1_Missense_Mutation_p.E219D|NFATC1_ENST00000329101.4_Missense_Mutation_p.E206D|NFATC1_ENST00000591814.1_Missense_Mutation_p.E219D|NFATC1_ENST00000586434.1_Missense_Mutation_p.E206D|NFATC1_ENST00000318065.5_Missense_Mutation_p.E206D|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.E219D|NFATC1_ENST00000427363.2_Missense_Mutation_p.E219D|NFATC1_ENST00000592223.1_Missense_Mutation_p.E206D	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	219	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		ACCCCGAGGAGGGCTTTCCCC	0.701000													2	2					0.00909568	0.00957083	0.009096	1	0
LSAMP	4045	broad.mit.edu	37	3	115805312	115805312	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:115805312G>T	ENST00000490035.1	-	2	746	c.247C>A	c.(247-249)Cgg>Agg	p.R83R	LSAMP_ENST00000539563.1_Silent_p.R80R	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	83	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		AGCTCAACCCGTGGGTCCAGA	0.502000													31	30					1.62565e-12	2.25459e-12	0.050027	1	0
ATM	472	broad.mit.edu	37	11	108143552	108143552	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:108143552G>T	ENST00000278616.4	+	22	3642	c.3257G>T	c.(3256-3258)cGc>cTc	p.R1086L	ATM_ENST00000452508.2_Missense_Mutation_p.R1086L	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1086					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R1086L(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CACCAAGTTCGCATGTTGGCT	0.368000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			23	11					1.66031e-10	2.2016e-10	0.021523	1	0
KCTD19	146212	broad.mit.edu	37	16	67328593	67328593	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:67328593A>C	ENST00000304372.5	-	11	1535	c.1480T>G	c.(1480-1482)Tgg>Ggg	p.W494G		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	494						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TCCTGAGTCCATGACCTGCAG	0.493000													13	23					0	0	0.024245	0	0
BRINP3	339479	broad.mit.edu	37	1	190250805	190250805	+	Silent	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:190250805G>T	ENST00000367462.3	-	3	543	c.312C>A	c.(310-312)gcC>gcA	p.A104A	FAM5C_ENST00000534846.1_Intron|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		104						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGAATTCAGGGGCAAGAGGCA	0.413000													22	30					1.10923e-09	1.40902e-09	0.016522	1	0
SLC27A1	376497	broad.mit.edu	37	19	17608205	17608205	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:17608205G>A	ENST00000252595.7	+	7	1235	c.1138G>A	c.(1138-1140)Gta>Ata	p.V380I	SLC27A1_ENST00000442725.1_Missense_Mutation_p.V380I|SLC27A1_ENST00000598424.1_Missense_Mutation_p.V201I|CTD-3131K8.2_ENST00000596643.1_lincRNA	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	380	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						GCGCTTCGGCGTACGCCAAAT	0.697000													6	9					0	0	0.021553	0	0
IGLL5	100423062	broad.mit.edu	37	22	23237850	23237850	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr22:23237850A>T	ENST00000532223.1	+	3	898	c.624A>T	c.(622-624)acA>acT	p.T208T	IGLL5_ENST00000526893.1_Silent_p.T207T|IGLC1_ENST00000390321.2_RNA|IGLL5_ENST00000531372.1_3'UTR			B9A064	IGLL5_HUMAN	immunoglobulin lambda-like polypeptide 5	207	C region (By similarity to lambda light- chain).|Ig-like C1-type.					extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|urinary_tract(1)	7						TGGAGAAGACAGTGGCCCCTA	0.617000													59	39					0	0	0.048971	0	0
NAV3	89795	broad.mit.edu	37	12	78513155	78513155	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:78513155C>A	ENST00000397909.2	+	15	3352	c.3179C>A	c.(3178-3180)aCt>aAt	p.T1060N	NAV3_ENST00000536525.2_Missense_Mutation_p.T1060N|NAV3_ENST00000266692.7_Missense_Mutation_p.T1060N|NAV3_ENST00000228327.6_Missense_Mutation_p.T1060N			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1060	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GGAAGATCGACTGCCACCAGC	0.498000										HNSCC(70;0.22)			68	55					2.165e-29	3.83178e-29	0.048971	1	0
SLC30A10	55532	broad.mit.edu	37	1	220089058	220089058	+	Silent	SNP	C	C	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:220089058C>G	ENST00000366926.3	-	4	1352	c.1191G>C	c.(1189-1191)ctG>ctC	p.L397L	SLC30A10_ENST00000484079.1_5'UTR|SLC30A10_ENST00000536446.1_Silent_p.L152L	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	397	Poly-Leu.				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		TGCAGAGCAACAGTAAGTCCT	0.532000													16	67					0	0	0.028581	0	0
ADRA1B	147	broad.mit.edu	37	5	159344583	159344583	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:159344583G>T	ENST00000306675.3	+	1	794	c.671G>T	c.(670-672)tGc>tTc	p.C224F		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	224					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	GTCATGTACTGCCGTGTCTAT	0.532000													34	61					2.20474e-14	3.29542e-14	0.064281	1	0
MALT1	10892	broad.mit.edu	37	18	56409163	56409163	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:56409163A>T	ENST00000348428.3	+	14	1928	c.1670A>T	c.(1669-1671)aAg>aTg	p.K557M	MALT1_ENST00000345724.3_Missense_Mutation_p.K546M|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	557	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						TTATCTGAGAAGAGAGCACTT	0.388000			T	BIRC3	MALT								21	38					0	0	0.014323	0	0
STX11	8676	broad.mit.edu	37	6	144507902	144507902	+	Silent	SNP	A	A	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:144507902A>T	ENST00000367568.4	+	2	321	c.138A>T	c.(136-138)cgA>cgT	p.R46R		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	46					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		CCCTGTACCGAGACATCCGGG	0.597000									Familial Hemophagocytic Lymphohistiocytosis				3	8					0	0	0.004672	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607070	84607070	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:84607070C>A	ENST00000344803.2	+	4	1732	c.1685C>A	c.(1684-1686)cCc>cAc	p.P562H		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1									p.P562R(2)									CAACCACTACCCTTGCCTCAA	0.507000													96	129					1.25439e-55	2.35825e-55	0.048971	1	0
DMD	1756	broad.mit.edu	37	X	31165492	31165492	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:31165492C>A	ENST00000357033.4	-	75	10903	c.10697G>T	c.(10696-10698)cGt>cTt	p.R3566L	DMD-AS1_ENST00000481143.1_RNA|DMD_ENST00000378707.3_Missense_Mutation_p.R1106L|DMD_ENST00000378677.2_Missense_Mutation_p.R3562L|DMD_ENST00000378723.3_Missense_Mutation_p.R498L|DMD_ENST00000359836.1_Missense_Mutation_p.R1093L|DMD_ENST00000378680.2_Missense_Mutation_p.R388L|DMD_ENST00000474231.1_Missense_Mutation_p.R1106L|DMD_ENST00000361471.4_Missense_Mutation_p.R485L|DMD_ENST00000343523.2_Missense_Mutation_p.R996L|DMD_ENST00000378702.4_Missense_Mutation_p.R498L|DMD_ENST00000541735.1_Missense_Mutation_p.R996L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3566					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.R1106H(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTGTGTTGACGCAGTAGCTT	0.567000													39	5					4.14481e-20	6.822e-20	0.025465	1	0
FIGN	55137	broad.mit.edu	37	2	164466341	164466341	+	Silent	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:164466341T>C	ENST00000333129.3	-	3	2315	c.2001A>G	c.(1999-2001)tcA>tcG	p.S667S	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	667						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						AATTGTGCTGTGAGAGCAGTT	0.463000													31	26					0	0	0.037714	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664661	169664661	+	RNA	SNP	C	C	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:169664661C>A	ENST00000483289.2	-	0	2633				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CTCACCCGCACAGCTGGCGGT	0.488000													8	7					2.74318e-10	3.59246e-10	0.058154	1	0
ARHGAP44	9912	broad.mit.edu	37	17	12862136	12862136	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:12862136G>T	ENST00000379672.5	+	16	1745	c.1445G>T	c.(1444-1446)cGg>cTg	p.R482L	ARHGAP44_ENST00000340825.3_Missense_Mutation_p.R482L|ARHGAP44_ENST00000262444.9_Missense_Mutation_p.R482L	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	482					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						CCTGCTGACCGGCGCCAGCCC	0.532000													10	3					5.16669e-11	7.02736e-11	0.010729	1	0
POLR2D	5433	broad.mit.edu	37	2	128605739	128605739	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:128605739T>C	ENST00000272645.4	-	4	427	c.371A>G	c.(370-372)gAt>gGt	p.D124G	POLR2D_ENST00000409698.1_Missense_Mutation_p.D86G|POLR2D_ENST00000409955.1_Missense_Mutation_p.D92G|POLR2D_ENST00000487079.1_5'UTR	NM_004805.3	NP_004796.1	O15514	RPB4_HUMAN	polymerase (RNA) II (DNA directed) polypeptide D	124					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding			large_intestine(1)|lung(4)|urinary_tract(1)	6	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		CAGCTCCTCATCTTCAAACCG	0.463000													8	37					0	0	0.058154	0	0
SOX3	6658	broad.mit.edu	37	X	139586819	139586819	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:139586819T>C	ENST00000370536.2	-	1	406	c.407A>G	c.(406-408)cAg>cGg	p.Q136R		NM_005634.2	NP_005625.2	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	136					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					CACACGGTCCTGGTCTGTACC	0.667000													11	5					0	0	0.013537	0	0
GTF3C2	2976	broad.mit.edu	37	2	27565996	27565996	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:27565996G>T	ENST00000359541.2	-	3	695	c.266C>A	c.(265-267)tCa>tAa	p.S89*	GTF3C2_ENST00000264720.3_Nonsense_Mutation_p.S89*			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	89						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAGACCTTTGACATCTCTGA	0.498000													21	23					1.22574e-08	1.51604e-08	0.014323	1	0
NELFCD	51497	broad.mit.edu	37	20	57564958	57564958	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:57564958A>G	ENST00000602795.1	+	7	805	c.757A>G	c.(757-759)Atg>Gtg	p.M253V	NELFCD_ENST00000344018.3_Missense_Mutation_p.M244V					negative elongation factor complex member C/D																		TGCCCAGGCCATGATGTCCGT	0.627000													28	50					0	0	0.030593	0	0
LOC101927412	101927412	broad.mit.edu	37	1	81068941	81068942	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:81068941_81068942insT	ENST00000443104.1	+	0	236																											taggtgtcaacttgattggatt	0.361													2	4	---	---	---	---					
LAMTOR5-AS1	101410535	broad.mit.edu	37	1	110967727	110967727	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:110967727delC	ENST00000585433.2	+	0	182				LAMTOR5-AS1_ENST00000599202.1_RNA|LAMTOR5-AS1_ENST00000598350.1_RNA|LAMTOR5-AS1_ENST00000598158.1_RNA|LAMTOR5-AS1_ENST00000596890.1_RNA																							CCTGTAGTCTCCCCACGCCTT	0.527													2	4	---	---	---	---					
RP4-543J13.1	0	broad.mit.edu	37	1	114771245	114771245	+	RNA	DEL	T	T	-	rs71090762		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:114771245delT	ENST00000420156.2	-	0	73																											AGGAtttctgttttttttttt	0.493													3	3	---	---	---	---					
LOC730102	730102	broad.mit.edu	37	1	177996558	177996558	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:177996558delA	ENST00000476232.1	-	0	494																											acttcgtctcaaaaaaaaaaa	0.547													2	4	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182181502	182181503	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:182181502_182181503insT	ENST00000449842.1	-	0	410																											CTTGTTTAAAGTTTTTTGATTC	0.322													2	4	---	---	---	---					
LOC400800	400800	broad.mit.edu	37	1	199329456	199329456	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:199329456delT	ENST00000452199.1	+	0	309																											agattttgccttcaaaataca	0.418													2	4	---	---	---	---					
KIF26B	55083	broad.mit.edu	37	1	245849625	245849626	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr1:245849625_245849626delGC	ENST00000366518.4	+	9	2301_2302	c.2197_2198delGC	c.(2197-2199)gfs	p.A733fs	KIF26B_ENST00000407071.2_Frame_Shift_Del_p.A1114fs			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1114	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.A1114V(2)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TTCCGGCGTGGCGTCTAGGGAG	0.624													29	22	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	3049791	3049792	+	RNA	INS	-	-	A	rs116478237	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:3049791_3049792insA	ENST00000457478.1	-	0	438																											tgtggtgtgtgtgtgtgtgtta	0.460													3	3	---	---	---	---					
AC073218.1	0	broad.mit.edu	37	2	34835037	34835037	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:34835037delT	ENST00000422558.1	+	0	475																											ctagggtaacttttttttcct	0.348													2	4	---	---	---	---					
LOC728730	728730	broad.mit.edu	37	2	39670699	39670700	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:39670699_39670700insA	ENST00000449569.1	+	0	120				AC007246.3_ENST00000426083.1_RNA|AC007246.3_ENST00000422128.1_RNA|AC007246.3_ENST00000445520.1_RNA|AC007246.3_ENST00000443038.1_RNA	NR_037875.1																						ctgagtagctggaactacaagc	0.500													2	4	---	---	---	---					
LOC728730	728730	broad.mit.edu	37	2	39753370	39753371	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:39753370_39753371insT	ENST00000449569.1	+	0	538				AC007246.3_ENST00000446698.1_RNA|AC007246.3_ENST00000426083.1_RNA|AC007246.3_ENST00000415640.1_RNA|AC007246.3_ENST00000422128.1_RNA|AC007246.3_ENST00000425775.1_RNA|AC007246.3_ENST00000451547.1_RNA|AC007246.3_ENST00000438649.1_RNA	NR_037875.1																						gaaacactgtatttttttgtct	0.465													2	4	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48207996	48207997	+	RNA	INS	-	-	T	rs35838157		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:48207996_48207997insT	ENST00000447571.1	-	0	441																		p.0?(2)									ttctttctttcttttttttttt	0.356													2	4	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48241989	48241989	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:48241989delA	ENST00000447571.1	-	0	240																		p.0?(2)									cttgtggattaaaaaaaaaaa	0.299													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52104481	52104481	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:52104481delT	ENST00000440698.1	+	0	879																											aacagagagctttttttttct	0.363													2	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58741845	58741846	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:58741845_58741846insT	ENST00000452840.1	+	0	195																											atcattttcacttttttttttt	0.386													2	4	---	---	---	---					
AC023115.2	0	broad.mit.edu	37	2	67473887	67473888	+	RNA	INS	-	-	A	rs72229278		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:67473887_67473888insA	ENST00000452716.1	+	0	110				AC023115.1_ENST00000594329.1_lincRNA																							GAAGACCATTTAAAAAAAAAAA	0.327													3	4	---	---	---	---					
PCBP1-AS1	400960	broad.mit.edu	37	2	70255432	70255432	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:70255432delG	ENST00000435880.2	-	0	651				PCBP1-AS1_ENST00000419963.1_RNA|PCBP1-AS1_ENST00000418564.1_RNA|PCBP1-AS1_ENST00000418308.1_RNA|PCBP1-AS1_ENST00000415742.1_RNA|PCBP1-AS1_ENST00000420309.1_RNA|PCBP1-AS1_ENST00000413436.1_RNA|PCBP1-AS1_ENST00000457770.1_RNA|PCBP1-AS1_ENST00000457076.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000601431.1_RNA|PCBP1-AS1_ENST00000415222.1_RNA|PCBP1-AS1_ENST00000434781.1_RNA|PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000599673.1_RNA|PCBP1-AS1_ENST00000594376.2_RNA|PCBP1-AS1_ENST00000411429.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000456161.1_RNA	NR_033872.1																						CAACTTTCTAGTATTACCCAC	0.428													2	4	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91882918	91882921	+	RNA	DEL	TTTT	TTTT	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:91882918_91882921delTTTT	ENST00000436174.1	-	0	1044																											ttccaattcctttttttttttttt	0.456													3	4	---	---	---	---					
AC108066.1	0	broad.mit.edu	37	2	213776293	213776293	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr2:213776293delA	ENST00000437261.1	+	0	60																											ACTAGAATGTAAAAAGTCCAG	0.448													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12054626	12054626	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:12054626delT	ENST00000432424.2	+	0	549							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TCTTTGTTCCTTTTTAAaatt	0.423													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18577503	18577504	+	RNA	DEL	AC	AC	-	rs3066854		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:18577503_18577504delAC	ENST00000595865.1	+	0	364				AC144521.1_ENST00000596152.1_RNA|AC144521.1_ENST00000600177.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000596139.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000598390.1_RNA																							ACTATCTACTacacacacacac	0.342													2	4	---	---	---	---					
AC133680.1	0	broad.mit.edu	37	3	24795760	24795761	+	RNA	INS	-	-	TT	rs141287779	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:24795760_24795761insTT	ENST00000455576.1	+	0	77																											gggaaagttacagcttccttca	0.386													2	4	---	---	---	---					
AC018359.1	0	broad.mit.edu	37	3	34337468	34337469	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:34337468_34337469insC	ENST00000424786.1	+	0	159																											TGAACATCCTTCCCCCTtgact	0.465													2	4	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106832555	106832555	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:106832555delA	ENST00000484698.1	-	0	295																											AGAAGGGAGTAAATGAGAATT	0.448													2	4	---	---	---	---					
PLSCR2	57047	broad.mit.edu	37	3	146127058	146127059	+	RNA	INS	-	-	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:146127058_146127059insG	ENST00000490344.1	-	0	143																											gcgagcccacagggggtgtcat	0.594													3	3	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146864506	146864506	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:146864506delA	ENST00000473299.1	-	0	229																											gtcagcaactaataatatcag	0.353													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153142101	153142101	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:153142101delG	ENST00000493214.2	-	0	381																											actaaacacaggaggagccag	0.358													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153511747	153511747	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:153511747delC	ENST00000488210.1	-	0	477																											aAGGTTCAAGCCCTTGAGCAG	0.413													2	4	---	---	---	---					
LINC00886	730091	broad.mit.edu	37	3	156469311	156469311	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:156469311delG	ENST00000472943.1	-	0	148					NR_038387.1																						AGTACATCTTGGGTGGTGCCG	0.552													2	4	---	---	---	---					
RP11-290K4.1	0	broad.mit.edu	37	3	157694470	157694470	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:157694470delT	ENST00000491909.1	-	0	345																											TGCTTCTTTGTACGTTGCATT	0.338													2	4	---	---	---	---					
MUC20	200958	broad.mit.edu	37	3	195447912	195447914	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr3:195447912_195447914delTTC	ENST00000320736.6	+	1	160_162	c.34_36delTTC	c.(34-36)del	p.F14del	MUC20_ENST00000436408.1_In_Frame_Del_p.F14del|MUC20_ENST00000485430.1_3'UTR|MUC20_ENST00000447234.2_In_Frame_Del_p.F14del	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	14					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TCTGCCCCTTTTCTTCTTCTGCT	0.611													3	3	---	---	---	---					
GBA3	57733	broad.mit.edu	37	4	22733156	22733156	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:22733156delG	ENST00000511446.1	+	0	61				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000503442.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						cagttacattgggggttagag	0.383													3	3	---	---	---	---					
RP11-123O22.1	0	broad.mit.edu	37	4	28508126	28508126	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:28508126delA	ENST00000509416.1	+	0	402																											agcaaaagggaaaaaaggccc	0.468													2	4	---	---	---	---					
LOC101928622	101928622	broad.mit.edu	37	4	34008934	34008936	+	RNA	DEL	CAT	CAT	-	rs111757710		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:34008934_34008936delCAT	ENST00000505018.1	-	0	59																											TGGTCATATACATCTCAAGCTAA	0.330													3	3	---	---	---	---					
SRD5A3-AS1	100506462	broad.mit.edu	37	4	56239346	56239346	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:56239346delA	ENST00000433175.2	-	0	268				SRD5A3-AS1_ENST00000598906.1_RNA|SRD5A3-AS1_ENST00000595103.1_RNA|SRD5A3-AS1_ENST00000596312.1_RNA|SRD5A3-AS1_ENST00000510637.1_RNA|SRD5A3-AS1_ENST00000595734.1_RNA|SRD5A3-AS1_ENST00000596289.1_RNA																							TATTGGGGGGAAAAAAAACAA	0.353													3	6	---	---	---	---					
RP11-685F15.1	0	broad.mit.edu	37	4	58470115	58470115	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:58470115delT	ENST00000509641.2	-	0	207																											agggtcatactttgctgaccc	0.358													2	4	---	---	---	---					
RP11-25H12.1	0	broad.mit.edu	37	4	66885662	66885663	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:66885662_66885663insA	ENST00000508572.1	+	0	463																											acaatagccacaaaaagaataa	0.342													2	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	80048579	80048580	+	RNA	DEL	AT	AT	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:80048579_80048580delAT	ENST00000509088.1	+	0	349				RP11-438E5.1_ENST00000513153.1_RNA|RP11-438E5.1_ENST00000510667.1_RNA	NR_038342.1																						tgttcagtgcatatatatatat	0.431													3	4	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82753608	82753609	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:82753608_82753609insA	ENST00000510780.1	-	0	336																											AAGGATGTTAGAAAAAAGACAA	0.441													2	4	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82865681	82865681	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:82865681delG	ENST00000510780.1	-	0	244																											TAGACAACAAGGATCTACCTT	0.473													2	4	---	---	---	---					
RP11-115D19.1	0	broad.mit.edu	37	4	90481053	90481053	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:90481053delT	ENST00000508021.1	+	0	70				RP11-115D19.1_ENST00000506864.1_RNA																							GAACTTGCTCTTTAAGACCCA	0.368													2	4	---	---	---	---					
LOC101929448	101929448	broad.mit.edu	37	4	104305969	104305970	+	RNA	INS	-	-	AC	rs148364228	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:104305969_104305970insAC	ENST00000508099.1	+	0	173																											ctatttttactacacacacaca	0.446													3	5	---	---	---	---					
RP11-729M20.1	0	broad.mit.edu	37	4	105201260	105201260	+	RNA	DEL	T	T	-	rs112422079		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:105201260delT	ENST00000514327.1	+	0	162																											tacagcaaccttttttttttt	0.318													2	4	---	---	---	---					
RP11-556I14.1	0	broad.mit.edu	37	4	105959490	105959490	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:105959490delT	ENST00000506386.1	+	0	71																											ggaggtggagtttgcagtgag	0.488													2	4	---	---	---	---					
RP11-679C8.2	0	broad.mit.edu	37	4	121116202	121116202	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:121116202delA	ENST00000508362.1	+	0	138				RP11-679C8.2_ENST00000504106.1_RNA																							GTCAGACAGCATGGGAAAGTG	0.383													2	4	---	---	---	---					
LOC100507487	100507487	broad.mit.edu	37	4	129359131	129359131	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:129359131delT	ENST00000511497.1	+	0	229																											tgtttgtttgtttttttgttt	0.308													2	4	---	---	---	---					
RP11-673E1.4	0	broad.mit.edu	37	4	144914148	144914149	+	RNA	INS	-	-	A	rs5862678	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:144914148_144914149insA	ENST00000506982.1	+	0	184																											aacagtgaagtaaaaaatgtcc	0.381													2	4	---	---	---	---					
RP11-18H21.2	0	broad.mit.edu	37	4	153069594	153069594	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:153069594delC	ENST00000504799.1	-	0	86																		p.?(1)									tagtagagtaccagcagcatt	0.418													2	4	---	---	---	---					
RP11-597D13.9	0	broad.mit.edu	37	4	159109759	159109766	+	RNA	DEL	ACACACAA	ACACACAA	-	rs59134152		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:159109759_159109766delACACACAA	ENST00000503611.1	+	0	969				RP11-597D13.9_ENST00000505532.1_RNA|RP11-597D13.9_ENST00000509463.1_RNA|RP11-597D13.9_ENST00000508752.1_RNA																							acacacacacacacacaAACTTCTGCAG	0.457													2	4	---	---	---	---					
ADAM29	11086	broad.mit.edu	37	4	175897362	175897362	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:175897362delT	ENST00000359240.3	+	5	1356	c.686delT	c.(685-687)gtfs	p.V229fs	ADAM29_ENST00000514159.1_Frame_Shift_Del_p.V229fs|ADAM29_ENST00000445694.1_Frame_Shift_Del_p.V229fs|ADAM29_ENST00000404450.4_Frame_Shift_Del_p.V229fs	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	229	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TATGTTATTGTTAATATAGTG	0.328													17	75	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190796250	190796250	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr4:190796250delC	ENST00000511785.1	-	0	231																											gcaaaggggaccacacatgca	0.448													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3450181	3450188	+	RNA	DEL	TATATATA	TATATATA	-	rs116677869		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:3450181_3450188delTATATATA	ENST00000505443.1	-	0	459					NR_033898.1																						tgtgtgtgtgtatatatatatatatata	0.346													3	5	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3465884	3465884	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:3465884delT	ENST00000505443.1	-	0	459					NR_033898.1																						ACATTTGGTATTAATTGaaaa	0.453													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3523929	3523929	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:3523929delC	ENST00000505443.1	-	0	459					NR_033898.1																						TGAAAACCTTCCCACCCTTCA	0.473													5	5	---	---	---	---					
CTD-2247C11.1	0	broad.mit.edu	37	5	5012704	5012705	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:5012704_5012705insA	ENST00000509057.1	-	0	228																											TCACAGCTCCCAAAAATGCAGT	0.421													2	4	---	---	---	---					
LOC101929412	101929412	broad.mit.edu	37	5	10496620	10496621	+	RNA	DEL	GT	GT	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:10496620_10496621delGT	ENST00000515243.1	-	0	1524																											catcacaatagtgtgtgtgtgt	0.505													2	4	---	---	---	---					
LOC646241	646241	broad.mit.edu	37	5	17851108	17851109	+	RNA	INS	-	-	T	rs111524838	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:17851108_17851109insT	ENST00000514771.1	+	0	115																											atcactgattatttttagttaa	0.213													2	4	---	---	---	---					
LOC646241	646241	broad.mit.edu	37	5	17902018	17902018	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:17902018delT	ENST00000514771.1	+	0	283																											atgcagactcttttttggttt	0.333													2	4	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20802338	20802338	+	RNA	DEL	A	A	-	rs141941317		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:20802338delA	ENST00000502427.1	+	0	395																											tagactaaccaaaaaaaaaaa	0.299													8	1	---	---	---	---					
RP11-152K4.2	0	broad.mit.edu	37	5	31107792	31107793	+	RNA	DEL	AA	AA	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:31107792_31107793delAA	ENST00000523584.1	-	0	267																											GATTTGGCTTAAAAACACACAC	0.351													2	4	---	---	---	---					
GDNF-AS1	100861519	broad.mit.edu	37	5	37873129	37873132	+	RNA	DEL	AAAC	AAAC	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:37873129_37873132delAAAC	ENST00000514532.2	+	0	2559					NR_103442.1																						ctgtctcaaaaaacaaacaaacaa	0.397													2	4	---	---	---	---					
CTD-2023N9.1	0	broad.mit.edu	37	5	56763092	56763092	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:56763092delT	ENST00000506106.1	+	0	119																											TCTGGCTTGCTTTTTTTTTTA	0.443													2	4	---	---	---	---					
RP11-232L2.2	0	broad.mit.edu	37	5	72434195	72434196	+	RNA	INS	-	-	GTGTGTGTGT	rs70973227	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:72434195_72434196insGTGTGTGTGT	ENST00000508255.1	-	0	173																											TGTGGTTAGGGGTGTGTGTGTG	0.545													2	4	---	---	---	---					
AC008834.1	0	broad.mit.edu	37	5	97458026	97458029	+	RNA	DEL	AGAG	AGAG	-	rs34984435		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:97458026_97458029delAGAG	ENST00000505908.1	-	0	454																											aaaaacaaacagagagcaacaaca	0.466													3	3	---	---	---	---					
STARD4-AS1	100505678	broad.mit.edu	37	5	110935455	110935455	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:110935455delT	ENST00000500779.2	+	0	283					NR_040093.1																						ACAGAGGGAATTTTTAAAGGT	0.318													2	4	---	---	---	---					
RP11-114H21.2	0	broad.mit.edu	37	5	135838421	135838421	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:135838421delA	ENST00000511165.1	+	0	209																											cttgaaagctaagtcaaattc	0.303													2	4	---	---	---	---					
LINC01024	100505636	broad.mit.edu	37	5	139453371	139453371	+	RNA	DEL	A	A	-	rs79706028		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:139453371delA	ENST00000523452.1	-	0	334																											atattatggtaaaaaaaaaat	0.318													2	4	---	---	---	---					
PCDHGA5	56110	broad.mit.edu	37	5	140744199	140744200	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:140744199_140744200delTG	ENST00000518069.1	+	1	302_303	c.302_303delTG	c.(301-303)cfs	p.L101fs	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGCCCACTGTGTGTGGTGA	0.500													22	28	---	---	---	---					
LOC101926941	101926941	broad.mit.edu	37	5	141891886	141891886	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:141891886delT	ENST00000443800.1	+	0	243				AC005592.2_ENST00000425963.1_RNA																							TCTTTCTTTCTTTTTTTTTTT	0.408													2	4	---	---	---	---					
LOC101926941	101926941	broad.mit.edu	37	5	141902499	141902499	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:141902499delT	ENST00000443800.1	+	0	243				AC005592.2_ENST00000425963.1_RNA																							attttccttattagtatataa	0.388													2	4	---	---	---	---					
CTD-2050E21.1	0	broad.mit.edu	37	5	142898095	142898095	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:142898095delT	ENST00000340585.6	-	0	437																											ttaaatgggatttttttttct	0.303													4	4	---	---	---	---					
CTC-359M8.1	0	broad.mit.edu	37	5	145739210	145739210	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:145739210delT	ENST00000515598.1	-	0	403																											aatggtagtattttttttttc	0.428													2	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164181330	164181330	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:164181330delT	ENST00000517508.1	+	0	759				CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA																							CTTGAACTCCttttttttttt	0.423													2	4	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	165156431	165156431	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:165156431delT	ENST00000522189.1	+	0	21																											CATGAAAGCCTTTGATGTCCA	0.368													2	4	---	---	---	---					
TENM2	57451	broad.mit.edu	37	5	167182137	167182137	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:167182137delG	ENST00000519204.1	+	1	197	c.79delG	c.(79-81)gcfs	p.G27fs	TENM2_ENST00000518659.1_Intron|TENM2_ENST00000520394.1_Frame_Shift_Del_p.G27fs|TENM2_ENST00000520393.1_Intron|TENM2_ENST00000545108.1_Intron					teneurin transmembrane protein 2																		ATGGAGACCCGGCAGTACCTC	0.527													258	417	---	---	---	---					
RP11-375B1.1	0	broad.mit.edu	37	5	176150464	176150465	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr5:176150464_176150465insC	ENST00000507236.1	-	0	219																											TTTTCCACTCTCCCCCCCAGCC	0.678													2	4	---	---	---	---					
RP3-448I9.1	0	broad.mit.edu	37	6	14396400	14396400	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:14396400delA	ENST00000434947.1	+	0	338																											ctgTGCTTAGAAAACGAGGTC	0.343													2	4	---	---	---	---					
RP11-146I2.1	0	broad.mit.edu	37	6	15032108	15032108	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:15032108delA	ENST00000437648.1	-	0	426																											gaagaagaagaaagaggaggg	0.388													3	3	---	---	---	---					
HCP5	10866	broad.mit.edu	37	6	31410206	31410209	+	RNA	DEL	GTGT	GTGT	-	rs71653278		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:31410206_31410209delGTGT	ENST00000414046.2	+	0	62				XXbac-BPG181B23.4_ENST00000430364.1_lincRNA	NR_040662.1		Q6MZN7	HCP5_HUMAN							defense response					urinary_tract(1)	1						TTTAGAAGGGgtgtgtgtgtgtgt	0.495													3	5	---	---	---	---					
LOC101929705	101929705	broad.mit.edu	37	6	44012438	44012439	+	RNA	INS	-	-	ACAC			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:44012438_44012439insACAC	ENST00000422059.1	-	0	156																											cacgctcacatacacacatatt	0.416													2	4	---	---	---	---					
RP3-463P15.1	0	broad.mit.edu	37	6	94891641	94891641	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr6:94891641delG	ENST00000424506.1	+	0	30																											GCCAATTAATGGAATGATTCA	0.358													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11393015	11393016	+	RNA	INS	-	-	T	rs11388930	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:11393015_11393016insT	ENST00000421121.1	+	0	113				AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000599875.1_RNA|AC004538.3_ENST00000445839.1_RNA																							AAATCGTATTCTTTTTGAGTTT	0.436													4	2	---	---	---	---					
LOC102659288	102659288	broad.mit.edu	37	7	17498738	17498738	+	RNA	DEL	T	T	-	rs58069692		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:17498738delT	ENST00000419463.1	+	0	324				AC019117.2_ENST00000439046.1_lincRNA																							tttatagaccttccccccagg	0.428													2	4	---	---	---	---					
JAZF1-AS1	100128081	broad.mit.edu	37	7	28246740	28246740	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:28246740delT	ENST00000455963.1	+	0	301				JAZF1-AS1_ENST00000436758.1_RNA																							tctggatacattttttttttc	0.418													3	5	---	---	---	---					
INHBA-AS1	285954	broad.mit.edu	37	7	41743388	41743389	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:41743388_41743389insA	ENST00000415848.2	+	0	173				INHBA-AS1_ENST00000420821.1_RNA|AC005027.3_ENST00000416150.1_RNA|INHBA-AS1_ENST00000422822.1_RNA	NR_027118.1																						cacacacacacacaACAACAAC	0.322													2	4	---	---	---	---					
AC010971.1	0	broad.mit.edu	37	7	49277013	49277014	+	RNA	DEL	TG	TG	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:49277013_49277014delTG	ENST00000440455.1	+	0	198																											tttaaatttctgtgtgtgtgtg	0.337													2	4	---	---	---	---					
RP4-724E13.2	0	broad.mit.edu	37	7	50996886	50996887	+	RNA	DEL	TG	TG	-	rs59007756		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:50996886_50996887delTG	ENST00000420449.1	+	0	24																											tgtatatttatgtgtgtgtgtg	0.421													4	4	---	---	---	---					
RP4-724E13.2	0	broad.mit.edu	37	7	51029561	51029561	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:51029561delG	ENST00000420449.1	+	0	24																											aaacaggtgtgggggagaaag	0.498													2	4	---	---	---	---					
GS1-278J22.2	0	broad.mit.edu	37	7	53627435	53627435	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:53627435delA	ENST00000412800.1	-	0	232																											TAGTAAGTTTAAACTACACAT	0.284													2	4	---	---	---	---					
RP11-1217F2.15	0	broad.mit.edu	37	7	57289365	57289365	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:57289365delA	ENST00000415836.1	-	0	151																											GCTGTAGCCCAAGCAAGCTAA	0.438													5	6	---	---	---	---					
RP11-142A5.1	0	broad.mit.edu	37	7	91054522	91054522	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:91054522delC	ENST00000456952.1	-	0	112																											AAGTTGTTTTCTTTGTCTTGT	0.453													2	4	---	---	---	---					
RP11-142A5.1	0	broad.mit.edu	37	7	91179175	91179175	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:91179175delA	ENST00000456952.1	-	0	112																											ACATCCATGTAAGACAGGAAC	0.428													2	4	---	---	---	---					
DPY19L2P2	349152	broad.mit.edu	37	7	102908403	102908403	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:102908403delT	ENST00000312132.4	-	0	2401																											AACATTTAGGTTTTTTTTTTC	0.448													2	4	---	---	---	---					
RP11-328J2.1	0	broad.mit.edu	37	7	119396816	119396818	+	RNA	DEL	TGT	TGT	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:119396816_119396818delTGT	ENST00000426413.1	-	0	216																											CTTTAATCTCTGTTGTTGTtgtt	0.350													2	4	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123734062	123734062	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:123734062delA	ENST00000484322.1	+	0	168																											ggaaacaactaaaaaaaaaat	0.373													2	4	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130701938	130701938	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr7:130701938delA	ENST00000451786.1	-	0	1655																											acctgaggtcaggagttcaag	0.478													2	4	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1196825	1196825	+	RNA	DEL	G	G	-	rs35473332		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:1196825delG	ENST00000517950.1	-	0	409																											AGATCAGTGTGGGAGTGATGG	0.567													2	4	---	---	---	---					
CTD-2541M15.1	0	broad.mit.edu	37	8	6554308	6554309	+	RNA	DEL	TC	TC	-	rs13260608	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:6554308_6554309delTC	ENST00000525186.1	-	0	39				CTD-2541M15.1_ENST00000522897.1_RNA|CTD-2541M15.1_ENST00000527490.1_RNA																							ttggtttgtttcttttttacat	0.386													2	4	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24277061	24277062	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:24277061_24277062insT	ENST00000519689.1	-	0	184				RP11-624C23.1_ENST00000523578.1_RNA																							AAAATAAGTTATTTTTTTTCTG	0.381													2	4	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24479315	24479316	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:24479315_24479316insA	ENST00000519689.1	-	0	184																											aaattaccaacaaaaaaagtcc	0.371													2	4	---	---	---	---					
RP1-84O15.2	0	broad.mit.edu	37	8	34154715	34154716	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:34154715_34154716insT	ENST00000522460.1	+	0	202																											CAAGGGTCTTGTTTTTTATCAC	0.347													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36431116	36431117	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:36431116_36431117insA	ENST00000524132.1	-	0	484																											ggccttaagagaaaaaaaaaat	0.460													2	4	---	---	---	---					
RP11-17A4.4	0	broad.mit.edu	37	8	57567311	57567312	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:57567311_57567312insC	ENST00000521215.1	-	0	316																											cctgatgcgcgccccccATCCT	0.515													2	4	---	---	---	---					
LOC286178	286178	broad.mit.edu	37	8	58660908	58660911	+	RNA	DEL	ACAC	ACAC	-	rs112241056		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:58660908_58660911delACAC	ENST00000518934.1	+	0	611_614				RP11-388G22.1_ENST00000520426.1_lincRNA																							cacatacacaacacacacacacac	0.475													2	4	---	---	---	---					
CLVS1	157807	broad.mit.edu	37	8	62198764	62198764	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:62198764delG	ENST00000521378.1	-	0	35																											TTAGTCACCTGGGGACTAAGT	0.468													2	4	---	---	---	---					
RP11-122C21.1	0	broad.mit.edu	37	8	92825448	92825448	+	RNA	DEL	A	A	-	rs142446269		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:92825448delA	ENST00000518416.1	-	0	285																											ATTCTTCAGCAAAAAAAATGG	0.348													3	3	---	---	---	---					
KB-1507C5.4	0	broad.mit.edu	37	8	103995520	103995521	+	RNA	INS	-	-	T	rs144747551	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:103995520_103995521insT	ENST00000517983.1	+	0	171																											atttttttgtgttgtttttttt	0.386													2	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	110029320	110029320	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:110029320delT	ENST00000522244.1	-	0	264																											CTTCTCTTCCTTTTTTTTTCA	0.373													2	4	---	---	---	---					
LINC00964	157381	broad.mit.edu	37	8	125861727	125861728	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:125861727_125861728insT	ENST00000533496.1	-	0	154																											CATTCCTCCACtttttttttct	0.421													2	4	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138857123	138857123	+	RNA	DEL	T	T	-	rs57422420		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:138857123delT	ENST00000518973.1	-	0	514																											GGACTGTACCTTGCATAAAAA	0.403													8	3	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	139061755	139061756	+	RNA	INS	-	-	CA	rs139336491	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr8:139061755_139061756insCA	ENST00000518973.1	-	0	514																											atacacaggcgcacacacacac	0.450													3	4	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2433030	2433031	+	RNA	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:2433030_2433031insT	ENST00000416826.2	-	0	1214																											atatgtttttatttttcttgga	0.356													2	4	---	---	---	---					
RP11-132E11.2	0	broad.mit.edu	37	9	17110478	17110479	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:17110478_17110479insC	ENST00000430545.1	+	0	123																											taacttctcctccccctacatt	0.277													2	4	---	---	---	---					
LOC100506834	100506834	broad.mit.edu	37	9	89604389	89604389	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:89604389delT	ENST00000415801.1	+	0	857					NR_049794.1																						ttcatctgtattagcacaaca	0.418													2	4	---	---	---	---					
LINC01508	101927873	broad.mit.edu	37	9	93173328	93173329	+	RNA	INS	-	-	A	rs142607171	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:93173328_93173329insA	ENST00000425666.1	-	0	59																											cttaaaaaaataaaaaaaaGTG	0.386													3	3	---	---	---	---					
LOC101928797	101928797	broad.mit.edu	37	9	120413200	120413200	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:120413200delC	ENST00000450938.1	+	0	161																											ccatcgttttcccaaatcaag	0.393													4	2	---	---	---	---					
RP11-281A20.1	0	broad.mit.edu	37	9	120607156	120607157	+	RNA	DEL	CA	CA	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr9:120607156_120607157delCA	ENST00000449730.1	-	0	336				RP11-281A20.2_ENST00000421509.2_lincRNA																							GTACACATTGcacacacacaca	0.351													3	3	---	---	---	---					
RP11-69C17.4	0	broad.mit.edu	37	10	2221205	2221205	+	RNA	DEL	A	A	-	rs56356026		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:2221205delA	ENST00000418524.2	-	0	289																											aacacaaagcaaaacatgctt	0.453													3	5	---	---	---	---					
RP11-799O21.2	0	broad.mit.edu	37	10	6937609	6937609	+	RNA	DEL	T	T	-	rs75138721		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:6937609delT	ENST00000457632.1	-	0	44																											gttctttgagttttttccccc	0.323													5	4	---	---	---	---					
TMEM72	643236	broad.mit.edu	37	10	45430531	45430532	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:45430531_45430532insC	ENST00000544540.1	+	4	907_908	c.423_424insC	c.(421-426)cccccafs	p.PP141fs	TMEM72-AS1_ENST00000450287.2_RNA			A0PK05	TMM72_HUMAN	transmembrane protein 72	259						integral to membrane				breast(2)|kidney(1)|large_intestine(2)|lung(10)	15						TCATTCCCCCTCCCCAGGCCCC	0.604													9	38	---	---	---	---					
RP11-123B3.2	0	broad.mit.edu	37	10	50644060	50644062	+	RNA	DEL	AAG	AAG	-	rs137987948		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:50644060_50644062delAAG	ENST00000423283.1	+	0	234																											aaaagaaagaaagaaaaaaaaaa	0.394													3	3	---	---	---	---					
RP11-71J2.1	0	broad.mit.edu	37	10	55051358	55051358	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:55051358delA	ENST00000449272.1	-	0	74																											GAATTAACTGAAAAAAAAAAC	0.308													3	3	---	---	---	---					
ZNF503-AS1	253264	broad.mit.edu	37	10	77116263	77116264	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:77116263_77116264insC	ENST00000416398.1	+	0	262				RP11-399K21.11_ENST00000418818.2_lincRNA	NR_038223.1																						gtgagccaccgcccccagccTA	0.559													2	4	---	---	---	---					
RP11-95I16.2	0	broad.mit.edu	37	10	122729900	122729901	+	RNA	INS	-	-	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr10:122729900_122729901insG	ENST00000414774.1	-	0	49																											TGAGTGGGGGAGGGGGGCATTT	0.510													2	4	---	---	---	---					
RP11-290F24.3	0	broad.mit.edu	37	11	6154038	6154038	+	RNA	DEL	C	C	-	rs63555160		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:6154038delC	ENST00000529961.1	-	0	286																											tttaacCattccccccgcttt	0.433													3	3	---	---	---	---					
RP11-290F24.3	0	broad.mit.edu	37	11	6196276	6196277	+	RNA	INS	-	-	A	rs146127009	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:6196276_6196277insA	ENST00000529961.1	-	0	286																											AGATGCAGGacaaaaaaaacaa	0.347													4	3	---	---	---	---					
RP11-35J10.5	0	broad.mit.edu	37	11	7748851	7748851	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:7748851delA	ENST00000527565.1	-	0	542																											ACCGTGACTGAAATTAAAATA	0.343													2	4	---	---	---	---					
BDNF-AS	497258	broad.mit.edu	37	11	27539247	27539250	+	RNA	DEL	CTTC	CTTC	-	rs36166308		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:27539247_27539250delCTTC	ENST00000499008.3	+	0	47				BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000502161.2_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000501176.2_RNA|BDNF-AS_ENST00000532965.1_RNA	NR_002832.2																						ttctttccttcttccttccttctt	0.358													2	4	---	---	---	---					
RP11-587D21.4	0	broad.mit.edu	37	11	27823195	27823195	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:27823195delT	ENST00000530663.1	-	0	147																											TATTATCTCATGTagagaggc	0.398													2	4	---	---	---	---					
CTD-2572N17.1	0	broad.mit.edu	37	11	42242250	42242250	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:42242250delA	ENST00000527757.1	-	0	354																											ttcttcacagaaaaaaaaatt	0.313													2	4	---	---	---	---					
CTD-2005H7.1	0	broad.mit.edu	37	11	86422614	86422614	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:86422614delA	ENST00000526206.1	+	0	29																											gaaacaaagtaaaaaaaaaaa	0.289													3	3	---	---	---	---					
RP11-164N3.3	0	broad.mit.edu	37	11	87843982	87843982	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:87843982delA	ENST00000528458.1	+	0	138																											actccatctcaaaaaaaaaaa	0.473													4	3	---	---	---	---					
DYNC2H1	79659	broad.mit.edu	37	11	103055733	103055734	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:103055733_103055734insT	ENST00000375735.2	+	41	6730_6731	c.6586_6587insT	c.(6586-6588)tggfs	p.W2196fs	DYNC2H1_ENST00000398093.3_Frame_Shift_Ins_p.W2196fs|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2196					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATAAGGGGACTTGGTGGAAAT	0.347													33	53	---	---	---	---					
LOC100507431	100507431	broad.mit.edu	37	11	130730716	130730717	+	RNA	INS	-	-	AGGCCCC	rs66463260	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:130730716_130730717insAGGCCCC	ENST00000533812.2	-	0	946																											TAAACCCTGCTAGagaggtgcg	0.530													2	4	---	---	---	---					
LOC283177	283177	broad.mit.edu	37	11	134357220	134357221	+	RNA	INS	-	-	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr11:134357220_134357221insG	ENST00000528482.2	+	0	3090_3091																											TCTATACCCGTGGGATTCTCCT	0.579													2	4	---	---	---	---					
RP11-153K16.2	0	broad.mit.edu	37	12	23363183	23363183	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:23363183delA	ENST00000538297.1	-	0	39																											TAGATGGCATAAATTCTATCT	0.453													2	4	---	---	---	---					
RP11-630C16.2	0	broad.mit.edu	37	12	42289772	42289773	+	RNA	INS	-	-	AATCAAACGAG	rs149520611	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:42289772_42289773insAATCAAACGAG	ENST00000550874.1	-	0	471																											caacttcctaaaagaaatacaa	0.267													3	4	---	---	---	---					
TMEM117	84216	broad.mit.edu	37	12	44781918	44781918	+	Frame_Shift_Del	DEL	G	G	-	rs150882895		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:44781918delG	ENST00000266534.3	+	8	1135	c.1008delG	c.(1006-1008)ccfs	p.P336fs	TMEM117_ENST00000536799.1_Frame_Shift_Del_p.P232fs|TMEM117_ENST00000551577.1_3'UTR|TMEM117_ENST00000546978.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	336						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		ATATCGGCCCGGGGCAGAAGA	0.378													30	51	---	---	---	---					
FLJ41278	400046	broad.mit.edu	37	12	65316365	65316365	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:65316365delA	ENST00000535058.1	+	0	594				RP11-766N7.4_ENST00000510459.2_lincRNA	NR_033988.1																						TTCCTGAGGCAGAGTGACTGC	0.483													2	4	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70501048	70501048	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:70501048delT	ENST00000549419.1	-	0	144																											TTGACTTTTCTtttttgtttg	0.378													2	4	---	---	---	---					
RP11-314D7.1	0	broad.mit.edu	37	12	73531127	73531127	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:73531127delA	ENST00000551135.1	-	0	104																											GGAGTTCCTGAAAAAAGGGGG	0.323													2	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	73759904	73759905	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:73759904_73759905insA	ENST00000549058.1	-	0	132																											acccccacctcaaaaaaaaaaa	0.426													2	4	---	---	---	---					
RP1-34H18.1	0	broad.mit.edu	37	12	77784312	77784313	+	RNA	INS	-	-	A	rs140060097	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:77784312_77784313insA	ENST00000550042.1	+	0	574				RP1-97G4.1_ENST00000552736.1_lincRNA																							aaaaagaaaacaattactgctg	0.436													2	4	---	---	---	---					
RP11-511B23.2	0	broad.mit.edu	37	12	93452456	93452457	+	RNA	DEL	TT	TT	-	rs34307567		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:93452456_93452457delTT	ENST00000550324.1	-	0	85				RP11-511B23.2_ENST00000549930.1_RNA																							tgccaaaatctttttttttttt	0.490													3	4	---	---	---	---					
RP11-511B23.2	0	broad.mit.edu	37	12	93516523	93516523	+	RNA	DEL	A	A	-	rs78707598		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:93516523delA	ENST00000550324.1	-	0	85				RP11-511B23.2_ENST00000549930.1_RNA																							ATGGGCAAAGAAAAAAAAAAA	0.408													3	6	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97388882	97388883	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:97388882_97388883insC	ENST00000552238.1	+	0	39																											CCTTCTGTCCTCCCCCCCGAAC	0.515													3	5	---	---	---	---					
RMST	196475	broad.mit.edu	37	12	97953944	97953946	+	RNA	DEL	AAG	AAG	-	rs142257159	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:97953944_97953946delAAG	ENST00000538559.2	+	0	1728																											ACTGCagaaaaagaagaagaaga	0.310													2	4	---	---	---	---					
RP11-690J15.1	0	broad.mit.edu	37	12	98614016	98614017	+	RNA	INS	-	-	A	rs138793241	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:98614016_98614017insA	ENST00000548344.1	-	0	36																											gaaaattacagaaaagttacca	0.317													3	3	---	---	---	---					
RP11-328J6.1	0	broad.mit.edu	37	12	103520443	103520443	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:103520443delA	ENST00000548594.1	-	0	167				RP11-328J6.1_ENST00000548415.1_RNA																							gaagttaactaaaaaAAAAAA	0.318													2	4	---	---	---	---					
RP11-357K6.2	0	broad.mit.edu	37	12	119259989	119259990	+	RNA	INS	-	-	T	rs148832842	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr12:119259989_119259990insT	ENST00000538783.1	-	0	232																											tcagcatatgattttttttctt	0.356													3	3	---	---	---	---					
RP11-114G1.2	0	broad.mit.edu	37	13	90149653	90149653	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr13:90149653delG	ENST00000425048.1	-	0	136																											aaggaagaaaggaaaaggaag	0.403													8	2	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20137696	20137696	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:20137696delG	ENST00000548261.1	+	0	391																											GCCCCGCCACGCCCGGGATTA	0.592													15	188	---	---	---	---					
LOC100507513	100507513	broad.mit.edu	37	14	21342625	21342627	+	RNA	DEL	CTT	CTT	-	rs35369494		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:21342625_21342627delCTT	ENST00000555481.1	-	0	600_602																											TGGTGGACTCCTTCTTATTTTTG	0.547													4	5	---	---	---	---					
RP11-998D10.4	0	broad.mit.edu	37	14	21581680	21581680	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:21581680delT	ENST00000320322.2	+	0	117																											CACCGCCTAATTTTTTTTCTT	0.438													2	4	---	---	---	---					
RP11-104E19.1	0	broad.mit.edu	37	14	25120015	25120015	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:25120015delT	ENST00000555300.1	+	0	177																											gtaccagtcctactgaaacta	0.383													2	4	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26588193	26588193	+	RNA	DEL	T	T	-	rs145143059		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:26588193delT	ENST00000546412.1	-	0	258																											cagctcaggatttttttttta	0.373													2	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	27751407	27751408	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:27751407_27751408insA	ENST00000553392.1	-	0	528																											GCTTCGTATACAAAAATTATGA	0.332													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46773260	46773260	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:46773260delT	ENST00000556886.1	+	0	232					NR_102701.1																						ttgtgctttgttttttttttt	0.308													2	4	---	---	---	---					
KTN1-AS1	100129075	broad.mit.edu	37	14	56035111	56035111	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:56035111delG	ENST00000412224.2	-	0	307				KTN1-AS1_ENST00000554558.1_RNA																							ttttttttttgacagggtctt	0.423													2	4	---	---	---	---					
LOC101927690	101927690	broad.mit.edu	37	14	57014070	57014070	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:57014070delT	ENST00000557246.1	+	0	187																											TCTAAAACTGTTTTTTTTTTA	0.303													2	4	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57530853	57530854	+	RNA	DEL	TG	TG	-	rs71104538		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:57530853_57530854delTG	ENST00000554725.1	+	0	344																											CTTATTAATTtgtgtgtgtgtg	0.347													3	2	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66816937	66816938	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:66816937_66816938insA	ENST00000556874.1	-	0	643																											ttccagagctgaaaaaaaaaat	0.272													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82326128	82326128	+	RNA	DEL	A	A	-	rs77837909		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:82326128delA	ENST00000554814.1	+	0	315																											gctctgtctcaaaaaaaaaaa	0.522													2	4	---	---	---	---					
RP11-452D21.1	0	broad.mit.edu	37	14	83486597	83486598	+	RNA	INS	-	-	AC	rs143956986	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:83486597_83486598insAC	ENST00000557709.1	-	0	96																											atttacaatagacacacacaca	0.391													4	3	---	---	---	---					
RP11-594C13.1	0	broad.mit.edu	37	14	87887876	87887877	+	RNA	DEL	GA	GA	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:87887876_87887877delGA	ENST00000557070.1	-	0	221																											AGCAAAGAATGAGAGAGAGAGA	0.416													2	4	---	---	---	---					
RP11-61O1.1	0	broad.mit.edu	37	14	98569304	98569305	+	RNA	INS	-	-	A	rs79975989		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:98569304_98569305insA	ENST00000555776.1	-	0	121																											AGTTTTTGATTAAAAAAAAAAA	0.436													3	3	---	---	---	---					
RP11-61O1.1	0	broad.mit.edu	37	14	98621534	98621535	+	RNA	INS	-	-	CA	rs72117685		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr14:98621534_98621535insCA	ENST00000555776.1	-	0	121																											TGCTCTCTCTCcacacacacac	0.371													3	3	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20591212	20591214	+	RNA	DEL	AGA	AGA	-	rs74264768		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:20591212_20591214delAGA	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TCTCAATGTCAGAAGAAGTATAA	0.369													3	6	---	---	---	---					
RP11-580I1.2	0	broad.mit.edu	37	15	24512630	24512631	+	RNA	INS	-	-	CT			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:24512630_24512631insCT	ENST00000566676.1	+	0	54																											tggtagaatgactgtgtgtgtg	0.426													7	3	---	---	---	---					
RP11-718O11.1	0	broad.mit.edu	37	15	46123311	46123311	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:46123311delA	ENST00000560705.1	+	0	556																											gtctttttccaaacgtagcag	0.453													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48244722	48244731	+	RNA	DEL	TGTGTGTGTG	TGTGTGTGTG	-	rs34501558		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:48244722_48244731delTGTGTGTGTG	ENST00000560900.1	+	0	195																											TAACCTCATCtgtgtgtgtgtgtgtgtgtg	0.429													3	4	---	---	---	---					
RP11-108K3.1	0	broad.mit.edu	37	15	51435941	51435941	+	RNA	DEL	T	T	-	rs36052874		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:51435941delT	ENST00000559909.1	+	0	194																											gcttttactattttttttttt	0.249													2	4	---	---	---	---					
RP11-34F13.3	0	broad.mit.edu	37	15	68152562	68152563	+	RNA	INS	-	-	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:68152562_68152563insG	ENST00000558889.1	+	0	121																											GTGGGTGTGCAGGGGGCACCGT	0.599													2	4	---	---	---	---					
LOC145837	145837	broad.mit.edu	37	15	69841497	69841498	+	RNA	INS	-	-	G			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:69841497_69841498insG	ENST00000560882.1	+	0	278																											TATTTCTGAATGGGGCATGCCA	0.455													2	4	---	---	---	---					
DNM1P35	100128285	broad.mit.edu	37	15	76024222	76024223	+	RNA	INS	-	-	CT	rs56851614	by1000genomes	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:76024222_76024223insCT	ENST00000501931.1	-	0	423					NR_024595.3																						GACCAGGTTTCctctctctctc	0.545													2	4	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84087094	84087094	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr15:84087094delC	ENST00000565495.1	+	0	264																											CCAAACTTTTCCAGTTTTCCA	0.498													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5338889	5338889	+	RNA	DEL	A	A	-	rs35104569		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:5338889delA	ENST00000569895.1	+	0	304																											gtactttgggaggccagggca	0.498													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5474833	5474834	+	RNA	INS	-	-	C	rs71404520		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:5474833_5474834insC	ENST00000569895.1	+	0	304																											tcctctcctctctttctttctt	0.366													4	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5826064	5826065	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:5826064_5826065insC	ENST00000569895.1	+	0	403																											GAAATGGCTTTCCCCTTTCATT	0.401													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5900198	5900198	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:5900198delA	ENST00000569895.1	+	0	403																											CCAGAGGGATAAGCGGAGGGG	0.478													2	4	---	---	---	---					
CTD-3037G24.3	0	broad.mit.edu	37	16	12688239	12688240	+	RNA	INS	-	-	T	rs34039482		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:12688239_12688240insT	ENST00000564505.1	-	0	307																											tcaacagaatatttttttttca	0.411													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18153991	18153991	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:18153991delA	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							CGTGCCTTGGAAAAGGGTGCC	0.468													2	4	---	---	---	---					
ADCY7	113	broad.mit.edu	37	16	50343538	50343538	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:50343538delC	ENST00000394697.2	+	18	2481	c.2141delC	c.(2140-2142)gcfs	p.A714fs	ADCY7_ENST00000254235.3_Frame_Shift_Del_p.A714fs|ADCY7_ENST00000537579.1_3'UTR|ADCY7_ENST00000566433.2_Frame_Shift_Del_p.A714fs|ADCY7_ENST00000538642.1_Frame_Shift_Del_p.A714fs			P51828	ADCY7_HUMAN	adenylate cyclase 7	714					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	AAGACAAGAGCCCTGTGTGAG	0.632													9	23	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72535518	72535518	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr16:72535518delT	ENST00000561611.2	-	0	113																											ATATTTACTGTTTCATGCTAT	0.318													2	4	---	---	---	---					
COX10-AS1	100874058	broad.mit.edu	37	17	13799989	13799989	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:13799989delA	ENST00000602743.1	-	0	348																											CTAGCAGAACAAAATCCTCAC	0.433													2	4	---	---	---	---					
RP11-218F4.1	0	broad.mit.edu	37	17	26285726	26285726	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:26285726delA	ENST00000567574.1	-	0	136																											TAGAATCTACAAAAAAAACTT	0.368													2	4	---	---	---	---					
RP11-445F12.1	0	broad.mit.edu	37	17	35220998	35220998	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:35220998delT	ENST00000528383.1	-	0	98																											agtgcagggctattttcactc	0.498													4	6	---	---	---	---					
AC004231.2	0	broad.mit.edu	37	17	39125980	39125980	+	RNA	DEL	T	T	-	rs34537300		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:39125980delT	ENST00000418393.1	+	0	385																											ttcaatactgttttttcaata	0.328													4	4	---	---	---	---					
KRT16	3868	broad.mit.edu	37	17	39767729	39767729	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:39767729delC	ENST00000301653.4	-	3	703	c.639delG	c.(637-639)cgfs	p.R213fs		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	213	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				CCACAGTCTGCCGCAGGGCCA	0.642													51	82	---	---	---	---					
CTC-501O10.1	0	broad.mit.edu	37	17	41763603	41763603	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr17:41763603delG	ENST00000593169.1	+	0	93																											tgcccaggctggagtataatg	0.507													2	4	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112443	112443	+	RNA	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:112443delC	ENST00000576266.1	+	0	77																											TAAAGCTCCTCCAGCAGAGCC	0.692													2	4	---	---	---	---					
RNMT	8731	broad.mit.edu	37	18	13762059	13762059	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:13762059delG	ENST00000592764.1	+	12	1612	c.1415delG	c.(1414-1416)agfs	p.R472fs	RNMT_ENST00000262173.3_3'UTR|RNMT_ENST00000535051.1_3'UTR|RNMT_ENST00000383314.2_3'UTR	NM_003799.1	NP_003790.1	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	0					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						ACTATTATGAGGGAGGCATGG	0.517													4	3	---	---	---	---					
AQP4-AS1	147429	broad.mit.edu	37	18	24464612	24464613	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:24464612_24464613insC	ENST00000568797.1	+	0	53				AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000578701.1_RNA|AQP4-AS1_ENST00000582605.1_RNA	NR_026908.1																						atcctactgtaccccccggaaa	0.431													3	5	---	---	---	---					
RP11-746B8.1	0	broad.mit.edu	37	18	30444205	30444205	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:30444205delA	ENST00000580366.1	+	0	27																											atgaggtcataaggactcctt	0.458													2	4	---	---	---	---					
RP11-746B8.1	0	broad.mit.edu	37	18	30480471	30480471	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:30480471delA	ENST00000580366.1	+	0	27																											gactttagagaaagtcctgag	0.478													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37353720	37353721	+	RNA	INS	-	-	C			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:37353720_37353721insC	ENST00000591629.1	-	0	250					NR_024391.1																						gtgtggcacctccccccatgca	0.475													2	4	---	---	---	---					
LOC284294	284294	broad.mit.edu	37	18	62086991	62086992	+	RNA	DEL	TG	TG	-	rs111335881		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:62086991_62086992delTG	ENST00000589376.1	+	0	977					NR_033881.1																						AGATTTGgtatgtgtgtgtgtg	0.381													3	5	---	---	---	---					
RP11-176N18.2	0	broad.mit.edu	37	18	75249412	75249412	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr18:75249412delG	ENST00000583629.1	+	0	497																											agcggagcctgcagaacagcg	0.542													3	3	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9059448	9059449	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:9059448_9059449insT	ENST00000397910.4	-	3	28200_28201	c.27997_27998insA	c.(27997-27999)cccfs	p.P9333fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9335	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGCCTGGGATGGATGTTCTG	0.500													65	16	---	---	---	---					
COL5A3	50509	broad.mit.edu	37	19	10087234	10087235	+	Splice_Site	INS	-	-	A	rs146470482	byFrequency	TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:10087234_10087235insA	ENST00000264828.3	-	45	3426_3427	c.3342_splice	c.e45+1	p.R1114_splice		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1114	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent	p.P1114L(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGCACTCACCGGGGGACCTGG	0.530													9	5	---	---	---	---					
AC007204.2	0	broad.mit.edu	37	19	20057921	20057921	+	RNA	DEL	G	G	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:20057921delG	ENST00000592245.1	+	0	72																											ctatcaatcaggcagtccttc	0.443													7	4	---	---	---	---					
CTC-457E21.6	0	broad.mit.edu	37	19	22790985	22790986	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:22790985_22790986insA	ENST00000599738.1	+	0	375																											GTGGCCCTGAGAGCCCAGTACC	0.644													5	9	---	---	---	---					
CTC-459F4.5	0	broad.mit.edu	37	19	28340992	28340993	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:28340992_28340993insA	ENST00000589471.1	-	0	118																											caagagaaagcaaaaaggcatg	0.441													2	4	---	---	---	---					
CTD-2050I18.1	0	broad.mit.edu	37	19	32040741	32040742	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:32040741_32040742insA	ENST00000593063.1	+	0	345																											accttctccccaaaactacaac	0.460													2	4	---	---	---	---					
CTD-2245F17.3	0	broad.mit.edu	37	19	53703995	53703995	+	RNA	DEL	T	T	-	rs113703393		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:53703995delT	ENST00000597550.1	+	0	232																											TGTTTCCCCCttttttttttt	0.473													3	3	---	---	---	---					
LILRA4	23547	broad.mit.edu	37	19	54849465	54849465	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr19:54849465delC	ENST00000291759.4	-	4	453	c.397delG	c.(397-399)tgfs	p.V133fs		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	133	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCTGAGGTCACCACAGGGCTT	0.582													12	13	---	---	---	---					
TAF4	6874	broad.mit.edu	37	20	60578330	60578335	+	Splice_Site	DEL	ACTACA	ACTACA	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr20:60578330_60578335delACTACA	ENST00000252996.3	-	9	2371	c.2371_splice	c.e9-1	p.791_splice	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	791					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CACCACAGGGACTACAAAACAAACAC	0.481													11	25	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11080077	11080078	+	RNA	INS	-	-	T	rs113638288		TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr21:11080077_11080078insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactGTGTGTGGAGGGTGGGGG	0.505													3	5	---	---	---	---					
LL22NC03-86D4.1	0	broad.mit.edu	37	22	34474930	34474931	+	RNA	INS	-	-	A			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr22:34474930_34474931insA	ENST00000412218.1	+	0	55																											aaaagcatatgaaaaactgctc	0.302													2	4	---	---	---	---					
LOC100506679	100506679	broad.mit.edu	37	22	43435095	43435095	+	RNA	DEL	T	T	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chr22:43435095delT	ENST00000443063.1	+	0	505																											aatcccagcattttgggaggc	0.448													2	4	---	---	---	---					
RP11-1M18.1	0	broad.mit.edu	37	X	6592052	6592052	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:6592052delA	ENST00000438499.1	-	0	252																											TCCATTACCCACCAAAGATAC	0.348													2	4	---	---	---	---					
NXF4	55999	broad.mit.edu	37	X	101821223	101821223	+	RNA	DEL	A	A	-			TCGA-17-Z016-01A-01W-0746-08	TCGA-17-Z016-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	39bbd67b-52fd-46e5-98cf-b5632400216d	34f7417a-8d8d-47dd-954e-350a69eedb39	g.chrX:101821223delA	ENST00000360035.2	+	0	1364					NR_002216.1															endometrium(2)|lung(8)	10						ACATAGTTTCAAGATGTCTTT	0.408													8	2	---	---	---	---					
