Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR97	222487	broad.mit.edu	37	16	57712186	57712186	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:57712186G>T	ENST00000333493.4	+	4	611	c.450G>T	c.(448-450)ttG>ttT	p.L150F	GPR97_ENST00000327655.6_5'UTR|GPR97_ENST00000450388.3_Missense_Mutation_p.L30F	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	150					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TGGTCCGCTTGGCCGTCACCA	0.582000													39	70					5.43694e-19	7.75707e-19	0.225048	1	0
PLEKHG2	64857	broad.mit.edu	37	19	39913447	39913447	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:39913447G>A	ENST00000425673.1	+	16	1991	c.1666G>A	c.(1666-1668)Gcc>Acc	p.A556T	PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.A526T|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.A585T|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	585					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CACATTCCAAGCCCTGCCCAG	0.612000													17	46					0	0	0.189662	0	0
BSN	8927	broad.mit.edu	37	3	49662731	49662731	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:49662731G>A	ENST00000296452.4	+	2	662	c.548G>A	c.(547-549)aGc>aAc	p.S183N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	183					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCGACCCCCAGCCAGCCAAAC	0.592000													20	55					0	0	0.234183	0	0
TRRAP	8295	broad.mit.edu	37	7	98547352	98547352	+	Nonsense_Mutation	SNP	C	C	T	rs149035665		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:98547352C>T	ENST00000359863.4	+	36	5211	c.5002C>T	c.(5002-5004)Cga>Tga	p.R1668*	TRRAP_ENST00000355540.3_Nonsense_Mutation_p.R1650*|TRRAP_ENST00000446306.3_Nonsense_Mutation_p.R1649*	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1668					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GAGCCAGTTGCGACGTGTGTG	0.532000													17	44					0	0	0.175082	0	0
WDR78	79819	broad.mit.edu	37	1	67288077	67288077	+	Silent	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:67288077C>G	ENST00000371026.3	-	16	2518	c.2463G>C	c.(2461-2463)ctG>ctC	p.L821L	WDR78_ENST00000431318.1_Silent_p.L534L	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	821										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						GCATATTTCTCAGTTCATACA	0.388000													10	63					0	0	0.069234	0	0
CCNT1	904	broad.mit.edu	37	12	49089837	49089837	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:49089837G>A	ENST00000261900.3	-	7	873	c.651C>T	c.(649-651)gaC>gaT	p.D217D		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	217					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGCTTCCCGTCAGTTGAGA	0.498000													16	42					0	0	0.160694	0	0
TKTL2	84076	broad.mit.edu	37	4	164393215	164393215	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:164393215C>A	ENST00000280605.3	-	1	1832	c.1672G>T	c.(1672-1674)Ggc>Tgc	p.G558C		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	558						cytoplasm	metal ion binding|transketolase activity	p.G558C(1)|p.G558S(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATAACTCGGCCGCCTGTGGCT	0.507000													17	49					1.00905e-13	1.3462e-13	0.204396	1	0
OBSCN	84033	broad.mit.edu	37	1	228492933	228492933	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:228492933G>T	ENST00000570156.2	+	54	14450	c.14376G>T	c.(14374-14376)aaG>aaT	p.K4792N	OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.K1469N|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3835					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGTGGAGGAAGGGACCTGAAA	0.572000													30	182					1.08312e-15	1.5066e-15	0.144211	1	0
CNN1	1264	broad.mit.edu	37	19	11651957	11651957	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:11651957C>T	ENST00000252456.2	+	2	341	c.130C>T	c.(130-132)Cgt>Tgt	p.R44C	CNN1_ENST00000588468.1_3'UTR|CNN1_ENST00000535659.2_5'UTR|CNN1_ENST00000592923.1_5'UTR|CNN1_ENST00000544952.1_Missense_Mutation_p.R24C	NM_001299.4	NP_001290.2	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	44	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						GGTGACAGGCCGTCGCATCGG	0.607000													22	65					0	0	0.083992	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714335	74714335	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:74714335G>C	ENST00000373032.3	-	1	201	c.109C>G	c.(109-111)Cgg>Ggg	p.R37G		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	37					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					CGGAGGTGCCGAAGGCCCCAG	0.572000													16	69					0	0	0.175082	0	0
FURIN	5045	broad.mit.edu	37	15	91419555	91419555	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:91419555G>T	ENST00000268171.3	+	3	527	c.248G>T	c.(247-249)cGg>cTg	p.R83L		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	83					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CACCGCCCGCGGCACAGCCGG	0.662000													7	33					0.0381472	0.0390622	0.038147	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	15					0	0	0.184627	0	0
PRPF38B	55119	broad.mit.edu	37	1	109242165	109242165	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:109242165G>C	ENST00000370021.1	+	7	1468	c.831G>C	c.(829-831)agG>agC	p.R277S	PRPF38B_ENST00000370025.4_Missense_Mutation_p.R388S			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	388	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		caagagaaaggtccaaggaac	0.408000													3	20					0	0	0.150653	0	0
OR2M2	391194	broad.mit.edu	37	1	248343905	248343905	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:248343905G>T	ENST00000359682.2	+	1	618	c.618G>T	c.(616-618)atG>atT	p.M206I		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTATAGTAATGCTTGTTTTCC	0.413000													29	211					1.08312e-15	1.5066e-15	0.144211	1	0
HUS1	3364	broad.mit.edu	37	7	48016360	48016360	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:48016360C>A	ENST00000258774.5	-	4	455	c.432G>T	c.(430-432)aaG>aaT	p.K144N	HUS1_ENST00000432325.1_Missense_Mutation_p.K123N	NM_004507.3	NP_004498.1	O60921	HUS1_HUMAN	HUS1 checkpoint homolog (S. pombe)	144					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|prostate(1)	13		Breast(660;0.00139)				CTTGTAAGTCCTTCCACAATT	0.428000								Direct reversal of damage;Other conserved DNA damage response genes					20	124					1.10513e-12	1.45e-12	0.069288	1	0
WDR66	144406	broad.mit.edu	37	12	122399998	122399998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:122399998G>T	ENST00000288912.4	+	15	3276	c.2422G>T	c.(2422-2424)Gaa>Taa	p.E808*	WDR66_ENST00000545752.1_3'UTR|WDR66_ENST00000397454.2_Nonsense_Mutation_p.E808*	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	808							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ACTCACCAGGGAACTCTTCCT	0.522000													9	58					1.58986e-06	1.86155e-06	0.069234	1	0
PSG6	5675	broad.mit.edu	37	19	43420600	43420600	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:43420600T>A	ENST00000187910.2	-	2	169	c.104A>T	c.(103-105)cAa>cTa	p.Q35L	PSG6_ENST00000601833.1_5'UTR|PSG6_ENST00000292125.2_Missense_Mutation_p.Q35L|PSG6_ENST00000402603.4_Missense_Mutation_p.Q35L	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				AATTATTACTTGGGCAGTGGT	0.453000													4	220					0	0	0.150653	0	0
PTPRM	5797	broad.mit.edu	37	18	7888352	7888352	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:7888352A>C	ENST00000332175.8	+	3	1482	c.445A>C	c.(445-447)Act>Cct	p.T149P	PTPRM_ENST00000580170.1_Missense_Mutation_p.T149P|PTPRM_ENST00000400060.4_Missense_Mutation_p.T149P|PTPRM_ENST00000400053.4_Missense_Mutation_p.T87P	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	149	MAM.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GGCCATTAGTACTTTCTGGCC	0.363000													53	71					0	0	0.139131	0	0
BRCA2	675	broad.mit.edu	37	13	32914374	32914374	+	Missense_Mutation	SNP	G	G	C	rs80358820		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:32914374G>C	ENST00000544455.1	+	11	6109	c.5882G>C	c.(5881-5883)aGt>aCt	p.S1961T	BRCA2_ENST00000380152.3_Missense_Mutation_p.S1961T	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1961					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGTAAATGTAGTATAGGGAAG	0.338000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			7	52					0	0	0.038147	0	0
KCNC1	3746	broad.mit.edu	37	11	17793833	17793833	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:17793833A>T	ENST00000379472.3	+	2	1222	c.1192A>T	c.(1192-1194)Atg>Ttg	p.M398L	KCNC1_ENST00000265969.6_Missense_Mutation_p.M398L	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	398						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CGTGGTCACCATGACGACCCT	0.642000													38	79					0	0	0.246493	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89246828	89246828	+	RNA	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:89246828A>G	ENST00000496168.1	-	0	522																											GAGAATAACTATTATACTGTT	0.507000													30	95					0	0	0.153744	0	0
TMC4	147798	broad.mit.edu	37	19	54675653	54675653	+	Silent	SNP	G	G	A	rs139603991	byFrequency	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:54675653G>A	ENST00000376591.4	-	2	428	c.297C>T	c.(295-297)gcC>gcT	p.A99A	TMC4_ENST00000476013.2_5'UTR|TMC4_ENST00000301187.4_Silent_p.A93A	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	99						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GTGCCCGTCTGGCCTGCATGG	0.657000													16	36					0	0	0.160694	0	0
TTLL1	25809	broad.mit.edu	37	22	43447822	43447822	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:43447822C>A	ENST00000266254.7	-	9	1203	c.963G>T	c.(961-963)aaG>aaT	p.K321N	TTLL1_ENST00000331018.7_Intron|AL022476.2_ENST00000443063.1_RNA	NM_012263.4	NP_036395.1	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	321	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		TCAGCCAGGGCTTCAGCTTGT	0.567000													18	40					3.62473e-10	4.60349e-10	0.234183	1	0
DHCR7	1717	broad.mit.edu	37	11	71155932	71155932	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:71155932T>C	ENST00000355527.3	-	3	343	c.67A>G	c.(67-69)Acc>Gcc	p.T23A	DHCR7_ENST00000407721.2_Missense_Mutation_p.T23A	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	23					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	TGAGATGCGGTTCTGTCATTG	0.507000									Smith-Lemli-Opitz syndrome				12	88					0	0	0.146539	0	0
MUC2	4583	broad.mit.edu	37	11	1101153	1101153	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:1101153T>A	ENST00000441003.2	+	41	7579	c.7552T>A	c.(7552-7554)Tgc>Agc	p.C2518S		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4880						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CGACACCTGCTGCAACATTAC	0.627000													3	8					0	0	0.217242	0	0
MYH8	4626	broad.mit.edu	37	17	10322030	10322030	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:10322030T>C	ENST00000403437.2	-	5	537	c.443A>G	c.(442-444)aAa>aGa	p.K148R	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	148	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTGGCGCTTTTTGCCTCTGTA	0.542000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				25	52					0	0	0.173368	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744396	135744396	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:135744396G>A	ENST00000375845.3	-	7	2076	c.2046C>T	c.(2044-2046)aaC>aaT	p.N682N	MAP3K19_ENST00000392915.1_Silent_p.N699N|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000358371.4_Silent_p.N569N|MAP3K19_ENST00000375844.3_Intron	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GGTAATACGTGTTTTCATCCC	0.418000													41	114					0	0	0.111260	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048566	42048566	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:42048566C>T	ENST00000372584.1	-	3	2917	c.1903G>A	c.(1903-1905)Ggt>Agt	p.G635S	HIVEP3_ENST00000247584.5_Missense_Mutation_p.G635S|HIVEP3_ENST00000429157.2_Missense_Mutation_p.G635S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.G635S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	635	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GTTTTCAAACCCTTCTTGGTC	0.478000													14	73					0	0	0.132662	0	0
PPFIA2	8499	broad.mit.edu	37	12	81851619	81851619	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:81851619T>C	ENST00000550584.2	-	4	625	c.330A>G	c.(328-330)ttA>ttG	p.L110L	PPFIA2_ENST00000443686.3_Silent_p.L36L|PPFIA2_ENST00000333447.7_Silent_p.L92L|PPFIA2_ENST00000549325.1_Silent_p.L92L|PPFIA2_ENST00000552948.1_Silent_p.L110L|PPFIA2_ENST00000550359.2_5'UTR|PPFIA2_ENST00000549396.1_Silent_p.L110L|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000548586.1_Silent_p.L110L|RP11-315E17.1_ENST00000550272.1_RNA|PPFIA2_ENST00000407050.4_Silent_p.L36L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	36										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGCAGGCATTTAATTCTTTTG	0.303000													8	14					0	0	0.058154	0	0
TLR9	54106	broad.mit.edu	37	3	52257640	52257640	+	Missense_Mutation	SNP	C	C	T	rs147300053		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:52257640C>T	ENST00000597542.1	-	9	1721	c.764G>A	c.(763-765)cGc>cAc	p.R255H	TLR9_ENST00000360658.2_Missense_Mutation_p.R231H|TLR9_ENST00000494383.1_Silent_p.P384P			Q9NR96	TLR9_HUMAN	toll-like receptor 9	231					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TTTGACGATGCGGTTGTAGGA	0.617000													3	30					0	0	0.115264	0	0
USP9X	8239	broad.mit.edu	37	X	41075524	41075524	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:41075524G>A	ENST00000324545.7	+	35	6337	c.5704G>A	c.(5704-5706)Gat>Aat	p.D1902N	USP9X_ENST00000378308.2_Missense_Mutation_p.D1902N	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1902					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TAAATTTGATGATGGTGATGT	0.408000													21	32					0	0	0.219247	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651148	84651148	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:84651148A>G	ENST00000286744.5	+	21	2992	c.2768A>G	c.(2767-2769)tAt>tGt	p.Y923C	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.Y923C	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	923	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCAGAGCCTATTTGCTGCCC	0.512000													17	84					0	0	0.160694	0	0
NPR3	4883	broad.mit.edu	37	5	32774829	32774829	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:32774829G>C	ENST00000265074.8	+	4	1418	c.1075G>C	c.(1075-1077)Gaa>Caa	p.E359Q	NPR3_ENST00000415685.2_Missense_Mutation_p.E143Q|NPR3_ENST00000415167.2_Missense_Mutation_p.E359Q|NPR3_ENST00000434067.2_Missense_Mutation_p.E143Q	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	359					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	CATGTTTGTTGAAGGATTCCA	0.438000													23	218					0	0	0.234183	0	0
GABRG1	2565	broad.mit.edu	37	4	46053535	46053535	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:46053535G>T	ENST00000295452.4	-	8	1204	c.1037C>A	c.(1036-1038)gCa>gAa	p.A346E		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	346					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CATCAAGGCTGCAAAAACAAA	0.373000													39	93					3.38236e-24	4.96616e-24	0.246493	1	0
MYOM2	9172	broad.mit.edu	37	8	2046745	2046745	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:2046745C>A	ENST00000262113.4	+	19	2513	c.2372C>A	c.(2371-2373)gCc>gAc	p.A791D	MYOM2_ENST00000523438.1_Missense_Mutation_p.A216D	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	791	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTCAACCTGGCCGGCATCGGG	0.562000													9	7					0.000274275	0.00029673	0.047766	1	0
TTN	7273	broad.mit.edu	37	2	179616533	179616533	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:179616533T>A	ENST00000360870.5	-	46	10816	c.10594A>T	c.(10594-10596)Act>Tct	p.T3532S	TTN_ENST00000342992.6_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3531	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCTGGAGTTGGACAGGCA	0.388000													16	59					0	0	0.132662	0	0
HTR1A	3350	broad.mit.edu	37	5	63257056	63257056	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:63257056C>A	ENST00000323865.3	-	1	724	c.491G>T	c.(490-492)gGc>gTc	p.G164V	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	164					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GATGAGGAAGCCAATAAGCCA	0.627000													17	68					1.45105e-14	1.97386e-14	0.175082	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256799	140256799	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:140256799T>A	ENST00000398631.2	+	1	1742	c.1742T>A	c.(1741-1743)gTa>gAa	p.V581E	PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGAGTTGGTACCGCGGTCG	0.667000													22	27					0	0	0.076483	0	0
PDE7A	5150	broad.mit.edu	37	8	66631608	66631608	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:66631608T>C	ENST00000401827.3	-	13	1809	c.1366A>G	c.(1366-1368)Aga>Gga	p.R456G	PDE7A_ENST00000379419.4_Missense_Mutation_p.R430G	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	456						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GACTGTTCTCTCTGCAGTCCC	0.483000													23	32					0	0	0.076483	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996477	140996477	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:140996477C>T	ENST00000285879.4	+	4	3573	c.3287C>T	c.(3286-3288)cCt>cTt	p.P1096L	MAGEC1_ENST00000406005.2_Missense_Mutation_p.P163L	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1096	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AATACCGTCCCTATTACCTTT	0.448000										HNSCC(15;0.026)			41	50					0	0	0.117977	0	0
HIVEP3	59269	broad.mit.edu	37	1	41979227	41979227	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:41979227C>T	ENST00000372584.1	-	7	6679	c.5665G>A	c.(5665-5667)Gca>Aca	p.A1889T	HIVEP3_ENST00000247584.5_Missense_Mutation_p.A1889T|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000429157.2_Missense_Mutation_p.A1889T|HIVEP3_ENST00000372583.1_Missense_Mutation_p.A1889T	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1889					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCCGCAGTGCATGTGGTGGG	0.657000													5	21					0	0	0.217242	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186048	127186048	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:127186048C>A	ENST00000371124.3	-	1	334	c.138G>T	c.(136-138)gtG>gtT	p.V46V		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	46						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TTGCTAAAGGCACATTGAATT	0.483000													57	44					4.33383e-22	6.29654e-22	0.139131	1	0
GVINP1	387751	broad.mit.edu	37	11	6739341	6739341	+	RNA	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:6739341A>T	ENST00000526769.2	-	0	3863																											CATTTTCCCCAGGAAGGCCAT	0.443000													2	2					0	0	0.115264	0	0
CNGB1	1258	broad.mit.edu	37	16	57937831	57937831	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:57937831T>C	ENST00000564448.1	-	27	2731	c.2671A>G	c.(2671-2673)Atg>Gtg	p.M891V	CNGB1_ENST00000251102.8_Missense_Mutation_p.M897V			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	897					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GTGCTGTCCATGCAGCTGCGG	0.572000													10	16					0	0	0.080935	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415064	88415064	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:88415064T>G	ENST00000418378.1	-	5	1459	c.888A>C	c.(886-888)caA>caC	p.Q296H	SPARCL1_ENST00000503414.1_Missense_Mutation_p.Q171H|SPARCL1_ENST00000282470.6_Missense_Mutation_p.Q296H	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	296					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTTTACCCTCTTGACTCTGCC	0.418000													5	329					0	0	0.029380	0	0
KRT5	3852	broad.mit.edu	37	12	52910570	52910570	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:52910570G>T	ENST00000252242.4	-	7	1680	c.1290C>A	c.(1288-1290)aaC>aaA	p.N430K		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	430	Coil 2.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		CGGCCAGCTTGTTCCTGGCAT	0.622000													22	171					1.10513e-12	1.45e-12	0.069288	1	0
DDX43	55510	broad.mit.edu	37	6	74104733	74104733	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:74104733G>C	ENST00000370336.4	+	1	263	c.105G>C	c.(103-105)ttG>ttC	p.L35F	OOEP_ENST00000370363.1_5'UTR|DDX43_ENST00000539829.1_Missense_Mutation_p.L35F	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	35						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CGGAGGAGTTGAATCGAACAG	0.657000													24	57					0	0	0.108266	0	0
XRRA1	143570	broad.mit.edu	37	11	74651834	74651834	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:74651834C>G	ENST00000340360.6	-	3	421	c.90G>C	c.(88-90)gaG>gaC	p.E30D	XRRA1_ENST00000527087.1_Missense_Mutation_p.E30D|XRRA1_ENST00000321448.8_Intron|XRRA1_ENST00000533598.1_Intron	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	30					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						CCTGACCTTCCTCCGGCACGC	0.498000													20	21					0	0	0.083992	0	0
SPTA1	6708	broad.mit.edu	37	1	158651402	158651402	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:158651402T>C	ENST00000368148.3	-	4	626	c.446A>G	c.(445-447)gAg>gGg	p.E149G	SPTA1_ENST00000368147.3_Missense_Mutation_p.E149G	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	149					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTCACCCTTCTCCAGGGTCAG	0.527000													26	139					0	0	0.099896	0	0
HYDIN	54768	broad.mit.edu	37	16	71012832	71012832	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:71012832T>G	ENST00000393567.2	-	30	4773	c.4623A>C	c.(4621-4623)gaA>gaC	p.E1541D		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1541										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CAGGCTCGTCTTCTGGCACTT	0.493000													10	33					0	0	0.069234	0	0
SMCR8	140775	broad.mit.edu	37	17	18226352	18226352	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:18226352G>C	ENST00000406438.3	+	2	3262	c.2782G>C	c.(2782-2784)Gac>Cac	p.D928H		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	928										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						GCTCAGGTTTGACTATGTCCC	0.547000													9	35					0	0	0.058154	0	0
LRP1B	53353	broad.mit.edu	37	2	141259351	141259351	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:141259351C>G	ENST00000389484.3	-	55	9726	c.8755G>C	c.(8755-8757)Ggt>Cgt	p.G2919R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2919	LDL-receptor class A 20.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCATCTGAACCATCGCCACAG	0.418000										TSP Lung(27;0.18)			14	36					0	0	0.119110	0	0
OR10J3	441911	broad.mit.edu	37	1	159284283	159284283	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:159284283A>G	ENST00000332217.5	-	1	166	c.167T>C	c.(166-168)cTt>cCt	p.L56P		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					GGGGGTGTGAAGATGATGGTC	0.458000													101	217					0	0	0.139131	0	0
ADCY4	196883	broad.mit.edu	37	14	24795299	24795299	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:24795299C>T	ENST00000310677.4	-	13	1754	c.1641G>A	c.(1639-1641)caG>caA	p.Q547Q	ADCY4_ENST00000396747.3_Silent_p.Q240Q|ADCY4_ENST00000554068.2_Silent_p.Q547Q|ADCY4_ENST00000418030.2_Silent_p.Q547Q	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	547					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GCGAGTTGAGCTGCTCAATGA	0.607000													12	87					0	0	0.080935	0	0
CNTN1	1272	broad.mit.edu	37	12	41386975	41386975	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:41386975C>G	ENST00000551295.2	+	17	2134	c.2017C>G	c.(2017-2019)Cca>Gca	p.P673A	CNTN1_ENST00000348761.2_Missense_Mutation_p.P662A|CNTN1_ENST00000347616.1_Missense_Mutation_p.P673A	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	673	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GGACTTAATCCCATGGATGGA	0.398000													28	63					0	0	0.116897	0	0
GRM3	2913	broad.mit.edu	37	7	86416430	86416430	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:86416430C>T	ENST00000361669.2	+	3	2421	c.1322C>T	c.(1321-1323)aCg>aTg	p.T441M	GRM3_ENST00000439827.1_Missense_Mutation_p.T441M|GRM3_ENST00000394720.2_Missense_Mutation_p.T439M|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.T313M	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	441					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ATCAACTTCACGGGTAAGCCA	0.403000													39	105					0	0	0.225048	0	0
PITX2	5308	broad.mit.edu	37	4	111539532	111539532	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:111539532G>C	ENST00000354925.2	-	7	2408	c.703C>G	c.(703-705)Ccg>Gcg	p.P235A	PITX2_ENST00000394598.2_Missense_Mutation_p.P235A|PITX2_ENST00000355080.5_Missense_Mutation_p.P189A|PITX2_ENST00000306732.3_Missense_Mutation_p.P242A|PITX2_ENST00000394595.3_Missense_Mutation_p.P166R	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	235					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTGGAGCCCGGGACGCCTGTC	0.597000													20	63					0	0	0.234183	0	0
NRROS	375387	broad.mit.edu	37	3	196387777	196387777	+	Silent	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:196387777C>G	ENST00000328557.4	+	3	1466	c.1263C>G	c.(1261-1263)ctC>ctG	p.L421L		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		CCCCTGGCCTCTTCGCCAATG	0.637000													6	63					0	0	0.217242	0	0
SCN10A	6336	broad.mit.edu	37	3	38802750	38802750	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:38802750G>C	ENST00000449082.2	-	6	815	c.816C>G	c.(814-816)ctC>ctG	p.L272L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	272					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTTATTTTTGAGGTTGCCCT	0.458000													3	81					0	0	0.150653	0	0
CTNND2	1501	broad.mit.edu	37	5	11346578	11346578	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:11346578C>T	ENST00000304623.8	-	9	1723	c.1534G>A	c.(1534-1536)Gtt>Att	p.V512I	CTNND2_ENST00000359640.2_Missense_Mutation_p.V512I|CTNND2_ENST00000458100.2_Missense_Mutation_p.V79I|CTNND2_ENST00000503622.1_Missense_Mutation_p.V175I|CTNND2_ENST00000511377.1_Missense_Mutation_p.V421I|CTNND2_ENST00000495388.2_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	512					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GGAGACTCAACAGAGGGACAA	0.612000													13	42					0	0	0.093190	0	0
ADCY8	114	broad.mit.edu	37	8	132051816	132051816	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:132051816G>T	ENST00000286355.5	-	1	2856	c.764C>A	c.(763-765)aCc>aAc	p.T255N	ADCY8_ENST00000377928.3_Missense_Mutation_p.T255N	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	255					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAGGATCTGGGTGGTCATGGC	0.637000										HNSCC(32;0.087)			31	19					7.11191e-15	9.69806e-15	0.173368	1	0
SOGA2	23255	broad.mit.edu	37	18	8813219	8813219	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:8813219G>T	ENST00000359865.3	+	12	2989	c.2847G>T	c.(2845-2847)tgG>tgT	p.W949C	SOGA2_ENST00000517570.1_Missense_Mutation_p.W908C|SOGA2_ENST00000400050.3_Missense_Mutation_p.W908C|SOGA2_ENST00000518815.1_Missense_Mutation_p.W302C|SOGA2_ENST00000306285.7_Missense_Mutation_p.W302C|SOGA2_ENST00000306329.11_Missense_Mutation_p.W1268C	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1259																	AATTCTTGTGGAGGATAGAGC	0.567000													4	32					0.00909568	0.0094181	0.150653	1	0
TTN	7273	broad.mit.edu	37	2	179540684	179540684	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:179540684C>A	ENST00000589042.1	-	148	34641	c.34417G>T	c.(34417-34419)Gtc>Ttc	p.V11473F	TTN_ENST00000342992.6_Missense_Mutation_p.V10200F|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V11127F|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11152	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGGAATGACCACTTTCTTC	0.363000													4	18					0.00024832	0.000270761	0.150653	1	0
MT1HL1	645745	broad.mit.edu	37	1	237167633	237167633	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:237167633C>A	ENST00000464121.2	-	1	85	c.40G>T	c.(40-42)Gcc>Tcc	p.A14S		NM_001276687.1	NP_001263616.1			metallothionein 1H-like 1																		CCGGCGCAGGCGTAGGAGCCT	0.627000													29	152					3.57733e-08	4.39252e-08	0.144211	1	0
TNN	63923	broad.mit.edu	37	1	175066708	175066708	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:175066708C>T	ENST00000239462.4	+	8	1857	c.1744C>T	c.(1744-1746)Cag>Tag	p.Q582*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	582	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGGGAAGGAGCAGAGCAGCAC	0.597000													22	44					0	0	0.083992	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147586	118147586	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:118147586C>T	ENST00000456015.2	+	1	20	c.20C>T	c.(19-21)aCg>aTg	p.T7M	SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000519688.1_5'UTR|SLC30A8_ENST00000427715.2_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	7					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CTTGAAAGAACGTATCTTGTG	0.428000													164	124					0	0	0.139131	0	0
CCDC134	79879	broad.mit.edu	37	22	42221805	42221805	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:42221805C>G	ENST00000255784.5	+	7	772	c.668C>G	c.(667-669)tCc>tGc	p.S223C	CCDC134_ENST00000402061.3_Missense_Mutation_p.S110C	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	223						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						CCAAGGATCTCCAGATCCCAG	0.567000													28	80					0	0	0.134883	0	0
COL11A1	1301	broad.mit.edu	37	1	103427760	103427760	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:103427760G>T	ENST00000358392.2	-	40	3439	c.3122C>A	c.(3121-3123)cCa>cAa	p.P1041Q	COL11A1_ENST00000512756.1_Missense_Mutation_p.P913Q|COL11A1_ENST00000370096.3_Missense_Mutation_p.P1029Q|COL11A1_ENST00000353414.4_Missense_Mutation_p.P990Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1029	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTTTCCCCTGGGAAACCACG	0.378000													27	70					6.38683e-12	8.32087e-12	0.134883	1	0
TAAR1	134864	broad.mit.edu	37	6	132967038	132967038	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:132967038C>A	ENST00000275216.1	-	1	104	c.105G>T	c.(103-105)ctG>ctT	p.L35L		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	35						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	CGAGTGTGGTCAGAATTATGA	0.393000													108	131					1.22118e-62	1.86196e-62	0.139131	1	0
HSPG2	3339	broad.mit.edu	37	1	22183555	22183555	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:22183555G>A	ENST00000374695.3	-	44	5607	c.5528C>T	c.(5527-5529)tCc>tTc	p.S1843F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1843	Ig-like C2-type 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AAACATGTTGGAGCCGGTGCA	0.567000													11	67					0	0	0.093190	0	0
LMNA	4000	broad.mit.edu	37	1	156096606	156096606	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:156096606C>T	ENST00000368297.1	+	2	115	c.13C>T	c.(13-15)Ctg>Ttg	p.L5L	LMNA_ENST00000361308.4_Intron|LMNA_ENST00000347559.2_Intron|LMNA_ENST00000473598.2_Intron|LMNA_ENST00000448611.2_Intron|LMNA_ENST00000392353.3_Silent_p.L5L|LMNA_ENST00000368299.3_Intron|LMNA_ENST00000368300.4_Intron|LMNA_ENST00000368301.2_Intron			P02545	LMNA_HUMAN	lamin A/C	0	Head.|Interaction with MLIP.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					GCAGCCACTCCTGTGCTTGGG	0.602000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				13	19					0	0	0.146539	0	0
UNC79	57578	broad.mit.edu	37	14	94053172	94053172	+	Missense_Mutation	SNP	C	C	A	rs138158671		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:94053172C>A	ENST00000553484.1	+	22	3104	c.2950C>A	c.(2950-2952)Ctg>Atg	p.L984M	UNC79_ENST00000256339.4_Missense_Mutation_p.L807M|UNC79_ENST00000393151.2_Missense_Mutation_p.L984M|UNC79_ENST00000555664.1_Missense_Mutation_p.L984M			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	984						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GATTCTCTGTCTGCATGGAGA	0.378000													24	27					2.39556e-15	3.2991e-15	0.076483	1	0
UBE3A	7337	broad.mit.edu	37	15	25616902	25616902	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:25616902C>G	ENST00000232165.3	-	6	1075	c.419G>C	c.(418-420)aGa>aCa	p.R140T	SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000566215.1_Missense_Mutation_p.R120T|UBE3A_ENST00000428984.2_Missense_Mutation_p.R120T|UBE3A_ENST00000397954.2_Missense_Mutation_p.R143T|UBE3A_ENST00000438097.1_Missense_Mutation_p.R120T	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	143					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		ATAATCCTCTCTTTCTCTACA	0.338000													5	37					0	0	0.184627	0	0
BRINP2	57795	broad.mit.edu	37	1	177250007	177250007	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:177250007C>A	ENST00000361539.4	+	8	2007	c.1695C>A	c.(1693-1695)caC>caA	p.H565Q	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		565						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GGCTGGTGCACGTGATGTTGG	0.577000													18	27					5.03518e-11	6.439e-11	0.189662	1	0
SH3BP5L	80851	broad.mit.edu	37	1	249106308	249106308	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:249106308C>A	ENST00000366472.5	-	7	2202	c.973G>T	c.(973-975)Ggc>Tgc	p.G325C	SH3BP5L_ENST00000411742.2_Missense_Mutation_p.G293C|SH3BP5L_ENST00000475978.1_5'UTR	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	325										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGGGCGGGGCCGGGCCCCAGG	0.711000													11	13					2.80697e-09	3.50872e-09	0.080935	1	0
AASDH	132949	broad.mit.edu	37	4	57220929	57220929	+	Silent	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:57220929A>T	ENST00000205214.6	-	7	1332	c.1152T>A	c.(1150-1152)gtT>gtA	p.V384V	AASDH_ENST00000602986.1_Silent_p.V231V|AASDH_ENST00000451613.1_Silent_p.V384V|AASDH_ENST00000502617.1_Silent_p.V384V|AASDH_ENST00000513376.1_Silent_p.V284V|AASDH_ENST00000434343.2_Intron	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	384					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CTCTGACTTCAACTACTGTTC	0.318000													15	54					0	0	0.132662	0	0
ITPR3	3710	broad.mit.edu	37	6	33654867	33654867	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:33654867C>T	ENST00000374316.5	+	45	7121	c.6061C>T	c.(6061-6063)Cgg>Tgg	p.R2021W	ITPR3_ENST00000605930.1_Missense_Mutation_p.R2021W			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	2021					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CATCAGCCTGCGGCCCCAGGA	0.657000													3	52					0	0	0.150653	0	0
PLXNA2	5362	broad.mit.edu	37	1	208315682	208315682	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:208315682C>G	ENST00000367033.3	-	4	2255	c.1498G>C	c.(1498-1500)Gag>Cag	p.E500Q		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	500	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACCTGTCTCTCAGACATGACG	0.498000													4	51					0	0	0.184627	0	0
ILF3	3609	broad.mit.edu	37	19	10789315	10789315	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:10789315G>T	ENST00000449870.1	+	6	903	c.586G>T	c.(586-588)Gac>Tac	p.D196Y	ILF3_ENST00000420083.1_Missense_Mutation_p.D196Y|ILF3_ENST00000250241.8_Missense_Mutation_p.D196Y|ILF3_ENST00000407004.3_Missense_Mutation_p.D196Y|ILF3_ENST00000318511.3_Missense_Mutation_p.D196Y|ILF3_ENST00000588657.1_Missense_Mutation_p.D196Y|ILF3_ENST00000590261.1_Missense_Mutation_p.D196Y|ILF3_ENST00000589998.1_Missense_Mutation_p.D196Y|ILF3_ENST00000592763.1_Missense_Mutation_p.D196Y	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	196	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CGACCCCCCGGACGTTCTGGA	0.502000													7	23					5.18039e-06	5.97737e-06	0.038147	1	0
HRG	3273	broad.mit.edu	37	3	186394878	186394878	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:186394878C>A	ENST00000232003.4	+	7	864	c.784C>A	c.(784-786)Ccc>Acc	p.P262T		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	262					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TTTGGGACATCCCTTCCACTG	0.468000													39	370					6.4771e-29	9.63751e-29	0.117977	1	0
PDGFRA	5156	broad.mit.edu	37	4	55127361	55127361	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:55127361T>G	ENST00000257290.5	+	3	480	c.149T>G	c.(148-150)tTt>tGt	p.F50C	FIP1L1_ENST00000507166.1_Intron|PDGFRA_ENST00000508170.1_Missense_Mutation_p.F50C	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	50	Ig-like C2-type 1.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTGAGATGCTTTGGGGAGAGT	0.463000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			31	98					0	0	0.153744	0	0
PKHD1	5314	broad.mit.edu	37	6	51918001	51918001	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:51918001G>T	ENST00000371117.3	-	21	2288	c.2013C>A	c.(2011-2013)ttC>ttA	p.F671L	PKHD1_ENST00000340994.4_Missense_Mutation_p.F671L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	671					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GGAGATCCCCGAAGCAACGCA	0.567000													16	54					6.33239e-15	8.65634e-15	0.219247	1	0
TCTN1	79600	broad.mit.edu	37	12	111078943	111078943	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:111078943C>G	ENST00000551590.1	+	9	1249	c.1093C>G	c.(1093-1095)Cat>Gat	p.H365D	HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397655.3_Missense_Mutation_p.H351D|TCTN1_ENST00000397659.4_Missense_Mutation_p.H365D|TCTN1_ENST00000377654.3_Missense_Mutation_p.H187D			Q2MV58	TECT1_HUMAN	tectonic family member 1	365					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						GTTTGAAATTCATTTTCTTCA	0.378000													5	52					0	0	0.217242	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113619945	113619945	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:113619945C>G	ENST00000358160.4	+	7	1100	c.608C>G	c.(607-609)gCt>gGt	p.A203G	GRAMD1C_ENST00000472026.1_Missense_Mutation_p.A36G|GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000440446.2_5'UTR|GRAMD1C_ENST00000479212.1_3'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	203						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						GGTTTAAATGCTGAGGAGATG	0.398000													11	81					0	0	0.105934	0	0
ZNF827	152485	broad.mit.edu	37	4	146696992	146696992	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:146696992C>G	ENST00000508784.1	-	10	2869	c.2642G>C	c.(2641-2643)aGc>aCc	p.S881T	ZNF827_ENST00000513320.1_Missense_Mutation_p.S531T|ZNF827_ENST00000379448.4_Missense_Mutation_p.S881T			Q17R98	ZN827_HUMAN	zinc finger protein 827	881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					GGTGACGGCGCTGACAATGTC	0.507000													20	84					0	0	0.204396	0	0
DNAH5	1767	broad.mit.edu	37	5	13729635	13729635	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:13729635T>C	ENST00000265104.4	-	69	11900	c.11796A>G	c.(11794-11796)ccA>ccG	p.P3932P		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3932					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGATGGTTTTGGAGGACAAG	0.353000									Kartagener syndrome				20	49					0	0	0.204396	0	0
C1orf112	55732	broad.mit.edu	37	1	169773226	169773226	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:169773226C>A	ENST00000286031.6	+	6	1023	c.323C>A	c.(322-324)tCt>tAt	p.S108Y	C1orf112_ENST00000359326.4_Missense_Mutation_p.S108Y|C1orf112_ENST00000498289.1_Intron|C1orf112_ENST00000456684.1_Missense_Mutation_p.S166Y|C1orf112_ENST00000413811.2_Missense_Mutation_p.S79Y	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	108										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AATAGTGAATCTGTGTATTCT	0.348000													4	30					0.00909568	0.0094181	0.150653	1	0
ZNF507	22847	broad.mit.edu	37	19	32873969	32873969	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:32873969A>G	ENST00000311921.3	+	6	3034	c.2842A>G	c.(2842-2844)Aca>Gca	p.T948A	ZNF507_ENST00000355898.5_Missense_Mutation_p.T948A|ZNF507_ENST00000544431.1_Missense_Mutation_p.T952A	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	948					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					GGACCACAATACAGCTCTAAA	0.398000													17	40					0	0	0.189662	0	0
WDR63	126820	broad.mit.edu	37	1	85550363	85550363	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:85550363G>A	ENST00000294664.6	+	6	705	c.525G>A	c.(523-525)acG>acA	p.T175T	WDR63_ENST00000370596.1_Silent_p.T175T|WDR63_ENST00000326813.8_Silent_p.T175T	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	175										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AATCAGTTACGGAATCTACAA	0.368000													9	85					0	0	0.069234	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967396	41967396	+	Missense_Mutation	SNP	C	C	A	rs144265671		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:41967396C>A	ENST00000298919.7	+	10	2423	c.2035C>A	c.(2035-2037)Cgc>Agc	p.R679S	PDZRN4_ENST00000539469.2_Missense_Mutation_p.R681S|PDZRN4_ENST00000402685.2_Missense_Mutation_p.R939S			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	939							ubiquitin-protein ligase activity|zinc ion binding	p.R681C(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAAATGGGGCGCTACTGGAG	0.542000													43	117					4.01765e-15	5.50567e-15	0.111260	1	0
EPHX1	2052	broad.mit.edu	37	1	226032230	226032230	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:226032230G>A	ENST00000366837.4	+	8	1268	c.1072G>A	c.(1072-1074)Gtc>Atc	p.V358I	EPHX1_ENST00000272167.5_Missense_Mutation_p.V358I|RP11-285F7.2_ENST00000424332.1_RNA	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	358					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					GCTGACCAACGTCATGCTCTA	0.567000													12	48					0	0	0.093190	0	0
LILRB2	10288	broad.mit.edu	37	19	54778671	54778671	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:54778671C>A	ENST00000391748.1	-	14	1787	c.1660G>T	c.(1660-1662)Gaa>Taa	p.E554*	LILRB2_ENST00000391749.4_Nonsense_Mutation_p.E555*|LILRB2_ENST00000314446.5_Nonsense_Mutation_p.E554*|LILRB2_ENST00000434421.1_Nonsense_Mutation_p.E439*|LILRB2_ENST00000391746.1_3'UTR	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	555					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGGGGCTTCAGATGCAGCA	0.632000													13	26					0.000151284	0.000166924	0.105934	1	0
C12orf10	60314	broad.mit.edu	37	12	53700879	53700879	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:53700879G>C	ENST00000267103.5	+	7	1129	c.1077G>C	c.(1075-1077)ttG>ttC	p.L359F	C12orf10_ENST00000549488.1_Missense_Mutation_p.L196F|C12orf10_ENST00000548632.1_Missense_Mutation_p.L284F	NM_021640.3	NP_067653.3	Q86UA3	Q86UA3_HUMAN	chromosome 12 open reading frame 10	359										cervix(1)|endometrium(3)|kidney(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	20						AGGGTGCCTTGAGCATGGCCC	0.572000													8	79					0	0	0.069234	0	0
CACNA1B	774	broad.mit.edu	37	9	140865867	140865867	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:140865867G>A	ENST00000371372.1	+	11	1511	c.1366G>A	c.(1366-1368)Ggg>Agg	p.G456R	CACNA1B_ENST00000277551.2_Missense_Mutation_p.G456R|CACNA1B_ENST00000371357.1_Missense_Mutation_p.G457R|CACNA1B_ENST00000371355.4_Missense_Mutation_p.G457R|CACNA1B_ENST00000371363.1_Missense_Mutation_p.G456R|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	456					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCTCAAGAGCGGGAAGACAGA	0.602000													7	8					0	0	0.047766	0	0
RASGRP3	25780	broad.mit.edu	37	2	33749054	33749054	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:33749054G>T	ENST00000403687.3	+	8	1365	c.625G>T	c.(625-627)Gtt>Ttt	p.V209F	RASGRP3_ENST00000407811.1_Missense_Mutation_p.V209F|RASGRP3_ENST00000402538.3_Missense_Mutation_p.V209F	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	209	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					CCAGTTGATGGTTCTTAGCAA	0.423000													37	219					3.33393e-15	4.58003e-15	0.214465	1	0
LRFN1	57622	broad.mit.edu	37	19	39805953	39805953	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:39805953C>A	ENST00000248668.4	-	1	23	c.24G>T	c.(22-24)tcG>tcT	p.S8S	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	8						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGAGGAGGGCCGAGGAGAAGG	0.711000													6	8					3.59834e-05	4.02636e-05	0.217242	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:178098810C>A	ENST00000397062.3	-	2	789	c.235G>T	c.(235-237)Gag>Tag	p.E79*	NFE2L2_ENST00000423513.1_Nonsense_Mutation_p.E63*|NFE2L2_ENST00000397063.4_Nonsense_Mutation_p.E63*|NFE2L2_ENST00000464747.1_Nonsense_Mutation_p.E63*|NFE2L2_ENST00000446151.2_Nonsense_Mutation_p.E63*	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E79K(10)|p.E79Q(10)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			9	53					0.000274275	0.00029673	0.047766	1	0
TRPM4	54795	broad.mit.edu	37	19	49686403	49686403	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:49686403G>C	ENST00000252826.5	+	12	1803	c.1677G>C	c.(1675-1677)tgG>tgC	p.W559C	TRPM4_ENST00000427978.2_Missense_Mutation_p.W559C|TRPM4_ENST00000355712.5_Missense_Mutation_p.W205C	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	559					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		AGGCCCCCTGGAGCGACCTGC	0.617000													15	44					0	0	0.160694	0	0
FSCN3	29999	broad.mit.edu	37	7	127239453	127239453	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:127239453G>T	ENST00000265825.5	+	5	1358	c.1139G>T	c.(1138-1140)gGg>gTg	p.G380V	FSCN3_ENST00000420086.2_Missense_Mutation_p.G246V	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	380						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						GAGGAATTTGGGATTTTATTT	0.498000													50	176					1.51943e-15	2.1082e-15	0.139131	1	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197230	39197230	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:39197230G>T	ENST00000306271.4	-	1	483	c.420C>A	c.(418-420)ccC>ccA	p.P140P		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	140						extracellular region|keratin filament				NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCAGGATGGGGGTGTGCAGC	0.672000													5	32					0.000602214	0.000647731	0.184627	1	0
CLASP1	23332	broad.mit.edu	37	2	122176272	122176272	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:122176272C>A	ENST00000263710.4	-	23	2635	c.2246G>T	c.(2245-2247)aGt>aTt	p.S749I	CLASP1_ENST00000455322.2_Intron|CLASP1_ENST00000541377.1_Intron|CLASP1_ENST00000541859.1_Intron|CLASP1_ENST00000545861.1_Intron|CLASP1_ENST00000397587.3_Intron|CLASP1_ENST00000409078.3_Intron	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	749	Interaction with microtubules, MAPRE1 and MAPRE3.|Ser-rich.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GCACCCCTGACTCATGCTGGG	0.552000													27	60					7.41945e-09	9.21207e-09	0.108266	1	0
TRIML2	205860	broad.mit.edu	37	4	189026491	189026491	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:189026491T>C	ENST00000536972.1	-	2	279	c.32A>G	c.(31-33)cAc>cGc	p.H11R	TRIML2_ENST00000512729.1_5'UTR			Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	0							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TGTGATGTTGTGCTGTAACTG	0.488000													11	13					0	0	0.069234	0	0
ABCC10	89845	broad.mit.edu	37	6	43413494	43413494	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:43413494G>C	ENST00000244533.3	+	13	3463	c.3104G>C	c.(3103-3105)gGc>gCc	p.G1035A	ABCC10_ENST00000372530.4_Missense_Mutation_p.G1063A	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1063	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTGGGCTCTGGCCTGCCCTGG	0.667000													7	55					0	0	0.029380	0	0
OR9G4	283189	broad.mit.edu	37	11	56510823	56510823	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:56510823G>C	ENST00000302957.3	-	1	464	c.465C>G	c.(463-465)ctC>ctG	p.L155L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GCCCAGTACAGAGGGCGGTGG	0.468000													53	124					0	0	0.139131	0	0
MAP4K3	8491	broad.mit.edu	37	2	39487787	39487787	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:39487787C>A	ENST00000263881.3	-	29	2592	c.2268G>T	c.(2266-2268)acG>acT	p.T756T	MAP4K3_ENST00000437545.1_Silent_p.T672T|MAP4K3_ENST00000536018.1_Silent_p.T309T|MAP4K3_ENST00000341681.5_Silent_p.T735T	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	756	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				TTGGATTGACCGTCTCAAATC	0.363000													13	19					1.49906e-05	1.69446e-05	0.119110	1	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238469	71238469	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:71238469C>G	ENST00000398536.4	+	1	157	c.123C>G	c.(121-123)tgC>tgG	p.C41W		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	41	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						CCGTCTGCTGCTGCAAGCCCG	0.687000													40	94					0	0	0.131918	0	0
MUC16	94025	broad.mit.edu	37	19	9075271	9075271	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:9075271T>C	ENST00000397910.4	-	3	12378	c.12175A>G	c.(12175-12177)Agc>Ggc	p.S4059G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4061	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGAATGAGCTGGATATTCTC	0.493000													117	401					0	0	0.139131	0	0
CTNNA2	1496	broad.mit.edu	37	2	80772119	80772119	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:80772119G>T	ENST00000466387.1	+	14	2027	c.1303G>T	c.(1303-1305)Gcc>Tcc	p.A435S	CTNNA2_ENST00000343114.3_Missense_Mutation_p.A114S|CTNNA2_ENST00000361291.4_Missense_Mutation_p.A469S|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A435S|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A435S|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A435S|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A435S			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	435					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGCCAATTTGGCCTGTTCCAT	0.473000													12	18					0.000151284	0.000166924	0.105934	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43858455	43858455	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:43858455T>C	ENST00000389420.3	-	10	1447	c.1448A>G	c.(1447-1449)tAt>tGt	p.Y483C	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.Y483C	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	483	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTTTCCATCATATCGTGATCC	0.393000													40	63					0	0	0.139131	0	0
OR51F2	119694	broad.mit.edu	37	11	4843115	4843115	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:4843115T>C	ENST00000322110.5	+	1	565	c.500T>C	c.(499-501)gTt>gCt	p.V167A	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAAGAAATGTTGCCGTCATG	0.438000													126	227					0	0	0.139131	0	0
ZNF613	79898	broad.mit.edu	37	19	52448126	52448126	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:52448126G>T	ENST00000293471.6	+	6	1669	c.990G>T	c.(988-990)agG>agT	p.R330S	ZNF613_ENST00000391794.4_Missense_Mutation_p.R294S	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		AAAGGTCCAGGCTCACTGAAC	0.468000													35	93					6.84511e-11	8.73342e-11	0.183431	1	0
PCDHAC1	56135	broad.mit.edu	37	5	140307540	140307540	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:140307540C>T	ENST00000253807.2	+	1	1063	c.1063C>T	c.(1063-1065)Cct>Tct	p.P355S	PCDHA8_ENST00000531613.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.P355S|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCTGCCCCTGGCACAGT	0.522000													26	55					0	0	0.091800	0	0
MYH11	4629	broad.mit.edu	37	16	15818778	15818778	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:15818778C>T	ENST00000338282.6	-	29	4036	c.3930G>A	c.(3928-3930)gtG>gtA	p.V1310V	MYH11_ENST00000576790.1_Silent_p.V1310V|MYH11_ENST00000396324.3_Silent_p.V1317V|MYH11_ENST00000300036.5_Silent_p.V1310V|NDE1_ENST00000342673.5_3'UTR|NDE1_ENST00000396355.1_3'UTR|NDE1_ENST00000396354.1_3'UTR|MYH11_ENST00000452625.2_Silent_p.V1317V|NDE1_ENST00000571896.1_3'UTR	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1310			V -> M (in dbSNP:rs7196804).		axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TGAGGGACGCCACGTCCTTGG	0.607000			T	CBFB	AML								18	29					0	0	0.204396	0	0
CSHL1	1444	broad.mit.edu	37	17	61987298	61987298	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:61987298C>T	ENST00000450719.3	-	3	650	c.413G>A	c.(412-414)tGg>tAg	p.W138*	CSHL1_ENST00000561003.1_Nonsense_Mutation_p.W149*|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000438387.2_Intron			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						AAGGAGAGACCAAGCGCTTGG	0.532000													42	43					0	0	0.139131	0	0
CHD7	55636	broad.mit.edu	37	8	61750662	61750662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:61750662G>T	ENST00000423902.2	+	19	4860	c.4381G>T	c.(4381-4383)Gag>Tag	p.E1461*	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1461	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAAAGAAATAGAGGATCTTCT	0.368000													7	21					8.12818e-05	9.02228e-05	0.029380	1	0
ADARB2	105	broad.mit.edu	37	10	1405977	1405977	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:1405977C>A	ENST00000381312.1	-	3	648	c.323G>T	c.(322-324)gGc>gTc	p.G108V		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	108					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCACAAGTGGCCCCCATTCCC	0.736000													3	16					0.115264	0.11695	0.115264	1	0
BUD13	84811	broad.mit.edu	37	11	116633908	116633908	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:116633908G>A	ENST00000260210.4	-	4	420	c.397C>T	c.(397-399)Cat>Tat	p.H133Y	BUD13_ENST00000375445.3_Missense_Mutation_p.H133Y	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	133	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGGTACCATGACGGACCCTC	0.537000													50	120					0	0	0.139131	0	0
APOBR	55911	broad.mit.edu	37	16	28508735	28508735	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:28508735C>A	ENST00000564831.1	+	2	2406	c.2373C>A	c.(2371-2373)gaC>gaA	p.D791E	APOBR_ENST00000431282.1_Missense_Mutation_p.D782E|APOBR_ENST00000328423.5_Missense_Mutation_p.D782E	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	782	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						AAGGCTGGGACTCGAAAGAAA	0.597000													7	65					8.12818e-05	9.02228e-05	0.029380	1	0
ARMCX5	64860	broad.mit.edu	37	X	101858564	101858564	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:101858564G>T	ENST00000604957.1	+	1	4117	c.1495G>T	c.(1495-1497)Gag>Tag	p.E499*	RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000536530.1_Nonsense_Mutation_p.E499*|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000246174.2_Nonsense_Mutation_p.E499*|ARMCX5_ENST00000541409.1_Nonsense_Mutation_p.E499*|ARMCX5_ENST00000537008.1_Nonsense_Mutation_p.E499*|ARMCX5_ENST00000372742.1_Nonsense_Mutation_p.E499*	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	499							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						TGAAATATTTGAGAATATAAA	0.313000													17	19					1.02788e-11	1.32361e-11	0.160694	1	0
XIRP2	129446	broad.mit.edu	37	2	168099706	168099706	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:168099706G>T	ENST00000409195.1	+	9	1893	c.1804G>T	c.(1804-1806)Ggc>Tgc	p.G602C	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G602C|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G380C|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	427					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TATTTCCAGGGGCATTGCTGA	0.433000													9	56					1.12685e-05	1.28419e-05	0.047766	1	0
GNPDA2	132789	broad.mit.edu	37	4	44705105	44705105	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:44705105C>A	ENST00000507917.1	-	6	853	c.722G>T	c.(721-723)gGa>gTa	p.G241V	GNPDA2_ENST00000507534.1_Missense_Mutation_p.G205V|GNPDA2_ENST00000295448.3_Missense_Mutation_p.G275V	NM_001270880.1	NP_001257809.1	Q8TDQ7	GNPI2_HUMAN	glucosamine-6-phosphate deaminase 2	275					N-acetylglucosamine metabolic process	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)	11						CCTTCAGTTTCCATCTTTCAT	0.333000													6	30					0.000157383	0.000172966	0.038147	1	0
DBT	1629	broad.mit.edu	37	1	100681576	100681576	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:100681576C>T	ENST00000370132.3	-	6	748	c.735G>A	c.(733-735)ccG>ccA	p.P245P	DBT_ENST00000370131.3_Silent_p.P245P	NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	245					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		CTGTGAATACCGGAGGTTTTG	0.383000													18	31					0	0	0.189662	0	0
DONSON	29980	broad.mit.edu	37	21	34951806	34951806	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr21:34951806C>G	ENST00000303071.5	-	9	1479	c.1413G>C	c.(1411-1413)gaG>gaC	p.E471D	DONSON_ENST00000453626.1_Intron|DONSON_ENST00000303113.6_Missense_Mutation_p.E457D|DONSON_ENST00000432378.1_Intron	NM_017613.3	NP_060083.1	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	471					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						GACCTGTAATCTCCAAACTAA	0.413000													4	93					0	0	0.150653	0	0
TMTC3	160418	broad.mit.edu	37	12	88542108	88542108	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:88542108C>G	ENST00000266712.6	+	2	236	c.16C>G	c.(16-18)Cta>Gta	p.L6V		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	6						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						TAATATTAACCTAAAAGAAAT	0.313000													8	39					0	0	0.047766	0	0
MACF1	23499	broad.mit.edu	37	1	39900087	39900087	+	Splice_Site	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:39900087A>G	ENST00000564288.1	+	69	18344	c.17565_splice	c.e69-1	p.E5856_splice	MACF1_ENST00000539005.1_Splice_Site_p.E3664_splice|MACF1_ENST00000545844.1_Splice_Site_p.E3794_splice|MACF1_ENST00000289893.4_Splice_Site_p.E4296_splice|MACF1_ENST00000372915.3_Splice_Site_p.E5752_splice|MACF1_ENST00000317713.7_Splice_Site_p.E3794_splice|MACF1_ENST00000361689.2_Splice_Site_p.E3794_splice|MACF1_ENST00000567887.1_Splice_Site_p.E5893_splice			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5860					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCACATAGGAAAAGACAGAG	0.328000													4	36					0	0	0.150653	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545674	234545674	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:234545674C>A	ENST00000344644.5	+	1	575	c.506C>A	c.(505-507)aCc>aAc	p.T169N	UGT1A10_ENST00000373445.1_Missense_Mutation_p.T169N|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTGGTCTTCACCAGGGGAATA	0.448000													31	127					9.78306e-22	1.41765e-21	0.144211	1	0
MITD1	129531	broad.mit.edu	37	2	99788098	99788098	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:99788098G>A	ENST00000289359.2	-	3	341	c.265C>T	c.(265-267)Cac>Tac	p.H89Y	MRPL30_ENST00000410042.1_Intron|MITD1_ENST00000466880.1_5'UTR	NM_138798.1	NP_620153.1	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport, domain containing 1	89					protein transport	late endosome membrane				large_intestine(3)|lung(2)|ovary(1)	6						ATTTGCTTGTGATATTTTCCA	0.308000													4	35					0	0	0.150653	0	0
TENM1	10178	broad.mit.edu	37	X	123556172	123556172	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:123556172G>A	ENST00000422452.2	-	24	4484	c.4421C>T	c.(4420-4422)gCc>gTc	p.A1474V	TENM1_ENST00000371130.3_Missense_Mutation_p.A1467V|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GTCAGTGGGGGCACCAGCGAT	0.468000													30	27					0	0	0.163468	0	0
USH2A	7399	broad.mit.edu	37	1	216062388	216062388	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:216062388G>A	ENST00000366943.2	-	41	7989	c.7603C>T	c.(7603-7605)Cct>Tct	p.P2535S	RP5-1111A8.3_ENST00000414995.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.P2535S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2535	Fibronectin type-III 12.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAACTACAGGTCCAGGTTCT	0.418000										HNSCC(13;0.011)			11	60					0	0	0.093190	0	0
MYH6	4624	broad.mit.edu	37	14	23863324	23863324	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:23863324C>T	ENST00000405093.3	-	21	2708	c.2638G>A	c.(2638-2640)Gtg>Atg	p.V880M	MYH6_ENST00000356287.3_Missense_Mutation_p.V880M	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	880					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.V880M(1)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCAGGGACACCATCTTCTCC	0.577000													15	56					0	0	0.119110	0	0
ATP1A3	478	broad.mit.edu	37	19	42490150	42490150	+	Splice_Site	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:42490150G>T	ENST00000545399.1	-	6	664	c.510_splice	c.e6-1	p.Q171_splice	ATP1A3_ENST00000543770.1_Splice_Site_p.Q169_splice|ATP1A3_ENST00000602133.1_Splice_Site_p.Q128_splice|ATP1A3_ENST00000302102.5_Splice_Site_p.Q158_splice	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	158					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						ACCAGGGCTTGCTGAGGTGGG	0.642000													51	149					9.40368e-32	1.41055e-31	0.139131	1	0
TNS3	64759	broad.mit.edu	37	7	47385804	47385804	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:47385804G>A	ENST00000398879.1	-	18	2798	c.2432C>T	c.(2431-2433)tCa>tTa	p.S811L	TNS3_ENST00000311160.9_Missense_Mutation_p.S811L|TNS3_ENST00000355730.3_Missense_Mutation_p.S571L			Q68CZ2	TENS3_HUMAN	tensin 3	811						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GTCCGCTGGTGAGGGGAATGG	0.592000													12	64					0	0	0.119110	0	0
ADAT1	23536	broad.mit.edu	37	16	75634175	75634175	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:75634175A>T	ENST00000307921.3	-	11	1593	c.1448T>A	c.(1447-1449)cTc>cAc	p.L483H	ADAT1_ENST00000568478.1_5'UTR|RP11-77K12.8_ENST00000564489.1_RNA	NM_012091.3	NP_036223.2	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	483	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						CTGCTTCCGGAGTGTGCTCCA	0.522000													4	68					0	0	0.150653	0	0
USP4	7375	broad.mit.edu	37	3	49337975	49337975	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:49337975C>T	ENST00000351842.4	-	10	1304	c.1296G>A	c.(1294-1296)ctG>ctA	p.L432L	USP4_ENST00000265560.4_Silent_p.L479L	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	479					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AGGGCAGTGGCAGCGTTAGAT	0.473000													17	36					0	0	0.189662	0	0
LPPR4	9890	broad.mit.edu	37	1	99771978	99771978	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:99771978C>G	ENST00000370185.3	+	7	2201	c.1704C>G	c.(1702-1704)aaC>aaG	p.N568K	LPPR4_ENST00000457765.1_Missense_Mutation_p.N510K|LPPR4_ENST00000370184.1_Missense_Mutation_p.N410K	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		568							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGGCCTGTAACAGAAGCAACA	0.537000													38	83					0	0	0.235728	0	0
NALCN	259232	broad.mit.edu	37	13	101997730	101997730	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:101997730C>T	ENST00000251127.6	-	7	767	c.686G>A	c.(685-687)tGc>tAc	p.C229Y	NALCN_ENST00000376196.3_Missense_Mutation_p.C229Y|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	229						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTCTGGTGAGCAGTGTGTGTC	0.433000													44	71					0	0	0.111260	0	0
LRP1B	53353	broad.mit.edu	37	2	140995833	140995833	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:140995833T>C	ENST00000389484.3	-	89	14419	c.13448A>G	c.(13447-13449)aAt>aGt	p.N4483S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4483					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTCCTCCATTGATAATAGG	0.299000										TSP Lung(27;0.18)			4	44					0	0	0.217242	0	0
NDUFA9	4704	broad.mit.edu	37	12	4796114	4796114	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:4796114C>A	ENST00000266544.5	+	11	994	c.974C>A	c.(973-975)aCa>aAa	p.T325K	RP11-234B24.6_ENST00000544741.2_Intron|NDUFA9_ENST00000540688.1_Missense_Mutation_p.T84K	NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	325					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	ATGCACATCACAGACATGAAA	0.483000													8	50					0.00448238	0.00469381	0.047766	1	0
KIF21A	55605	broad.mit.edu	37	12	39698630	39698630	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:39698630T>A	ENST00000395670.3	-	34	4975	c.4556A>T	c.(4555-4557)tAc>tTc	p.Y1519F	KIF21A_ENST00000361418.5_Missense_Mutation_p.Y1518F|KIF21A_ENST00000544797.2_Missense_Mutation_p.Y1481F|KIF21A_ENST00000361961.3_Missense_Mutation_p.Y1505F|KIF21A_ENST00000541463.2_Missense_Mutation_p.Y1465F			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1518					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TACTTTGATGTAATGATCCTT	0.353000													5	18					0	0	0.217242	0	0
NRXN3	9369	broad.mit.edu	37	14	79746711	79746711	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:79746711G>T	ENST00000281127.7	+	1	956	c.77G>T	c.(76-78)tGg>tTg	p.W26L	NRXN3_ENST00000428277.2_Missense_Mutation_p.W26L|NRXN3_ENST00000554719.1_Intron|NRXN3_ENST00000557594.1_Missense_Mutation_p.W26L|NRXN3_ENST00000335750.5_Intron	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	26					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTCCTGTTCTGGGGATGTATC	0.592000													50	110					5.39261e-20	7.73359e-20	0.139131	1	0
SULF2	55959	broad.mit.edu	37	20	46291890	46291890	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:46291890T>G	ENST00000359930.4	-	17	3145	c.2294A>C	c.(2293-2295)gAg>gCg	p.E765A	SULF2_ENST00000467815.1_Missense_Mutation_p.E765A|SULF2_ENST00000361612.4_Missense_Mutation_p.E765A|SULF2_ENST00000484875.1_Missense_Mutation_p.E765A	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	765					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						ATTGTGAGTCTCATTGATGGT	0.517000											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	21					0	0	0.047766	0	0
MST1L	11223	broad.mit.edu	37	1	17083652	17083652	+	RNA	SNP	C	C	T	rs113710576	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:17083652C>T	ENST00000455405.2	-	0	936																											aaatctcaaccttgagtacaa	0.388000													4	60					0	0	0.150653	0	0
SYT10	341359	broad.mit.edu	37	12	33535420	33535420	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:33535420G>T	ENST00000228567.3	-	5	1530	c.1234C>A	c.(1234-1236)Cga>Aga	p.R412R	SYT10_ENST00000535526.1_Silent_p.R231R	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	412	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTTAATCTTCGACCTTCACAC	0.343000													12	70					1.49906e-05	1.69446e-05	0.119110	1	0
SEMA5A	9037	broad.mit.edu	37	5	9052083	9052083	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:9052083C>T	ENST00000382496.5	-	20	3412	c.2747G>A	c.(2746-2748)cGc>cAc	p.R916H		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	916	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CTGGCGGGCGCGGACTTGGAC	0.612000													7	10					0	0	0.029380	0	0
LAMA4	3910	broad.mit.edu	37	6	112460430	112460430	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:112460430G>T	ENST00000230538.7	-	24	3571	c.3174C>A	c.(3172-3174)gcC>gcA	p.A1058A	LAMA4_ENST00000424408.2_Silent_p.A1051A|LAMA4_ENST00000522006.1_Silent_p.A1051A|LAMA4_ENST00000389463.4_Silent_p.A1051A	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1058	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CTCTCACCACGGCATAACCGG	0.493000													45	79					6.68952e-21	9.66845e-21	0.131918	1	0
CDC5L	988	broad.mit.edu	37	6	44374186	44374186	+	Silent	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:44374186A>G	ENST00000371477.3	+	7	1184	c.885A>G	c.(883-885)ctA>ctG	p.L295L		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	295	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAAGCAAACTAGTACTTCCTG	0.323000													3	111					0	0	0.150653	0	0
ELMO1	9844	broad.mit.edu	37	7	36895172	36895172	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:36895172A>G	ENST00000310758.4	-	22	2815	c.2168T>C	c.(2167-2169)gTc>gCc	p.V723A	ELMO1_ENST00000442504.1_Missense_Mutation_p.V723A|ELMO1_ENST00000396040.2_Missense_Mutation_p.V243A|ELMO1_ENST00000396045.3_Missense_Mutation_p.V243A|ELMO1_ENST00000341056.3_Missense_Mutation_p.V425A|ELMO1_ENST00000448602.1_Missense_Mutation_p.V723A	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	723					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						ACAGTCATAGACGAAGTCATA	0.547000													52	178					0	0	0.139131	0	0
KIAA1407	57577	broad.mit.edu	37	3	113737669	113737669	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:113737669T>G	ENST00000295878.3	-	8	1165	c.1019A>C	c.(1018-1020)cAt>cCt	p.H340P	KIAA1407_ENST00000545063.1_Missense_Mutation_p.H171P	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	340										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTAATCCTATGATCAAGAAT	0.483000													82	461					0	0	0.139131	0	0
RNASE8	122665	broad.mit.edu	37	14	21526388	21526388	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:21526388G>T	ENST00000308227.2	+	1	408	c.337G>T	c.(337-339)Ggg>Tgg	p.G113W	NDRG2_ENST00000403829.3_Intron	NM_138331.1	NP_612204.1	Q8TDE3	RNAS8_HUMAN	ribonuclease, RNase A family, 8	113						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0188)		GCTCACCTCAGGGAAGTACCC	0.552000													87	308					5.92634e-42	8.98666e-42	0.139131	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88886189	88886189	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:88886189T>C	ENST00000319675.3	-	1	107	c.11A>G	c.(10-12)aAa>aGa	p.K4R		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	4										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						TCGCGGTCTTTTGCTCTCCAT	0.527000													10	20					0	0	0.080935	0	0
GSG1	83445	broad.mit.edu	37	12	13243530	13243530	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:13243530G>T	ENST00000337630.6	-	2	299	c.232C>A	c.(232-234)Caa>Aaa	p.Q78K	GSG1_ENST00000537302.1_Missense_Mutation_p.Q78K|GSG1_ENST00000432710.2_Missense_Mutation_p.Q91K|GSG1_ENST00000351606.6_Missense_Mutation_p.Q91K|GSG1_ENST00000324458.8_Missense_Mutation_p.Q91K|GSG1_ENST00000396302.3_Missense_Mutation_p.Q78K|GSG1_ENST00000396310.2_Missense_Mutation_p.Q75K|GSG1_ENST00000457134.2_Missense_Mutation_p.Q78K	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	78						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		CAGTTGTATTGTACCACCTCC	0.567000													17	252					1.02788e-11	1.32361e-11	0.160694	1	0
NAALADL2	254827	broad.mit.edu	37	3	175184864	175184864	+	Silent	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:175184864T>G	ENST00000454872.1	+	8	1553	c.1425T>G	c.(1423-1425)cgT>cgG	p.R475R	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	475					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CGTTTATCCGTGCCTTGATGT	0.438000													14	285					0	0	0.146539	0	0
ELAVL1	1994	broad.mit.edu	37	19	8032642	8032642	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:8032642C>G	ENST00000407627.2	-	5	592	c.463G>C	c.(463-465)Gac>Cac	p.D155H	ELAVL1_ENST00000596459.1_Missense_Mutation_p.D155H|ELAVL1_ENST00000593807.1_Intron|ELAVL1_ENST00000351593.5_Missense_Mutation_p.D182H	NM_001419.2	NP_001410.2	Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	155	RRM 2.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GACCGTTTGTCAAACCGGATA	0.463000													4	13					0	0	0.150653	0	0
FCGBP	8857	broad.mit.edu	37	19	40408112	40408112	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:40408112G>C	ENST00000221347.6	-	9	4616	c.4609C>G	c.(4609-4611)Cac>Gac	p.H1537D		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1537	Cys-rich.|TIL 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGCTCGTAGTGACTGTTCGGA	0.657000													4	21					0	0	0.150653	0	0
WDFY3	23001	broad.mit.edu	37	4	85771070	85771070	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:85771070A>G	ENST00000322366.6	-	5	696	c.289T>C	c.(289-291)Tca>Cca	p.S97P	WDFY3_ENST00000295888.4_Missense_Mutation_p.S97P			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	97						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GATTTGTTTGATGCTCTCCTT	0.363000													45	102					0	0	0.139131	0	0
MS4A1	931	broad.mit.edu	37	11	60231794	60231794	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:60231794G>T	ENST00000534668.1	+	4	602	c.313G>T	c.(313-315)Gag>Tag	p.E105*	MS4A1_ENST00000528313.1_Intron|MS4A1_ENST00000389939.2_Nonsense_Mutation_p.E105*|MS4A1_ENST00000345732.4_Nonsense_Mutation_p.E105*|MS4A1_ENST00000532073.1_Nonsense_Mutation_p.E105*	NM_152866.2	NP_690605.1	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member 1	105					B cell activation|immune response	integral to plasma membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	GGCAGCAACGGAGAAAAACTC	0.453000													20	34					3.5997e-14	4.82568e-14	0.069288	1	0
NRK	203447	broad.mit.edu	37	X	105168748	105168748	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:105168748G>C	ENST00000428173.2	+	19	3343	c.3040G>C	c.(3040-3042)Gag>Cag	p.E1014Q	NRK_ENST00000243300.9_Missense_Mutation_p.E1013Q			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1013							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TCGTGGAAAAGAGGAAGCCTA	0.478000										HNSCC(51;0.14)			9	41					0	0	0.047766	0	0
NPSR1	387129	broad.mit.edu	37	7	34867155	34867155	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:34867155G>C	ENST00000360581.1	+	5	749	c.621G>C	c.(619-621)tgG>tgC	p.W207C	NPSR1_ENST00000381542.1_Missense_Mutation_p.W141C|NPSR1_ENST00000359791.1_Missense_Mutation_p.W207C|NPSR1_ENST00000381539.3_Missense_Mutation_p.W207C|NPSR1_ENST00000531252.1_Missense_Mutation_p.W196C	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	207						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	ACTCCTACTGGACCCCATACA	0.562000													4	155					0	0	0.184627	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457999	66457999	+	RNA	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:66457999C>A	ENST00000424345.1	+	0	67																											ATGCTGCTGCCTGGCGGTGCT	0.731000													3	18					0.0215528	0.0221515	0.217242	1	0
PIP4K2C	79837	broad.mit.edu	37	12	57994800	57994800	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:57994800G>T	ENST00000354947.5	+	8	1036	c.1020G>T	c.(1018-1020)cgG>cgT	p.R340R	PIP4K2C_ENST00000540759.2_Silent_p.R340R|PIP4K2C_ENST00000422156.3_Silent_p.R292R|PIP4K2C_ENST00000550465.1_Silent_p.R322R			Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	340	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(13)|pancreas(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Melanoma(17;0.122)					ATTCCCATCGGCCCCTGGGCC	0.577000													73	124					1.76847e-28	2.62434e-28	0.139131	1	0
PROKR1	10887	broad.mit.edu	37	2	68872970	68872970	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:68872970G>A	ENST00000303786.3	+	2	437	c.17G>A	c.(16-18)gGg>gAg	p.G6E	PROKR1_ENST00000394342.2_Missense_Mutation_p.G6E			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	6						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.G6E(1)		endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ACCACCATGGGGTTCATGGAT	0.542000													16	52					0	0	0.146539	0	0
PDE9A	5152	broad.mit.edu	37	21	44108033	44108033	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr21:44108033G>C	ENST00000335440.6	+	2	112	c.76G>C	c.(76-78)Gac>Cac	p.D26H	PDE9A_ENST00000398236.3_Intron|PDE9A_ENST00000349112.3_Intron|PDE9A_ENST00000328862.6_Intron|PDE9A_ENST00000398227.3_Intron|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398224.3_Intron|PDE9A_ENST00000335512.4_Silent_p.T49T|PDE9A_ENST00000398225.3_Silent_p.T8T|PDE9A_ENST00000539837.1_Silent_p.T14T|PDE9A_ENST00000398229.3_Silent_p.T8T|PDE9A_ENST00000291539.6_Silent_p.T49T|PDE9A_ENST00000398232.3_Intron|PDE9A_ENST00000398234.3_Silent_p.T8T|PDE9A_ENST00000380328.2_Silent_p.T49T	NM_001001578.1	NP_001001578.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	0					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						CCAGGAACACGACCATCTCCC	0.597000													9	35					0	0	0.058154	0	0
KCNK13	56659	broad.mit.edu	37	14	90650564	90650564	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:90650564C>T	ENST00000282146.4	+	2	885	c.444C>T	c.(442-444)cgC>cgT	p.R148R		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	148						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TCCTGGAGCGCCTGATCACCA	0.567000													12	28					0	0	0.132662	0	0
ZNF490	57474	broad.mit.edu	37	19	12691673	12691673	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:12691673G>A	ENST00000311437.6	-	5	1338	c.1216C>T	c.(1216-1218)Cag>Tag	p.Q406*	CTD-2192J16.20_ENST00000593682.1_Silent_p.F39F	NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						TCGTGCAACTGAAGGTAACTT	0.383000													19	131					0	0	0.219247	0	0
HMGCR	3156	broad.mit.edu	37	5	74646642	74646642	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:74646642A>G	ENST00000287936.4	+	9	965	c.809A>G	c.(808-810)cAc>cGc	p.H270R	HMGCR_ENST00000343975.5_Missense_Mutation_p.H270R|HMGCR_ENST00000511206.1_Missense_Mutation_p.H270R	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	270					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding	p.H270L(1)		breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GTTCATGCTCACAGTCGCTGG	0.368000													22	66					0	0	0.083992	0	0
ZNF248	57209	broad.mit.edu	37	10	38121619	38121619	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:38121619C>A	ENST00000395867.3	-	6	1214	c.664G>T	c.(664-666)Ggc>Tgc	p.G222C	ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000357328.4_Missense_Mutation_p.G222C|ZNF248_ENST00000374648.3_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						TCATGGAAGCCTTGTCCATTT	0.348000													20	51					4.35082e-09	5.41413e-09	0.219247	1	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Splice_Site	SNP	C	C	T	rs55863639		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:7579312C>T	ENST00000420246.2	-	4	507	c.375_splice	c.e4+1	p.T125_splice	TP53_ENST00000359597.4_Splice_Site_p.T125_splice|TP53_ENST00000269305.4_Splice_Site_p.T125_splice|TP53_ENST00000413465.2_Splice_Site_p.T125_splice|TP53_ENST00000445888.2_Splice_Site_p.T125_splice|TP53_ENST00000455263.2_Splice_Site_p.T125_splice	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	125	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		T -> A (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(51)|p.0?(8)|p.?(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	299					0	0	0.029380	0	0
DZIP3	9666	broad.mit.edu	37	3	108343296	108343296	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:108343296C>G	ENST00000361582.3	+	6	611	c.381C>G	c.(379-381)caC>caG	p.H127Q	DZIP3_ENST00000463306.1_Missense_Mutation_p.H127Q	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	127					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TGTAGGCACACCAGATTAATA	0.279000													6	33					0	0	0.217242	0	0
CTNNA2	1496	broad.mit.edu	37	2	80772120	80772120	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:80772120C>T	ENST00000466387.1	+	14	2028	c.1304C>T	c.(1303-1305)gCc>gTc	p.A435V	CTNNA2_ENST00000343114.3_Missense_Mutation_p.A114V|CTNNA2_ENST00000361291.4_Missense_Mutation_p.A469V|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A435V|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A435V|CTNNA2_ENST00000541047.1_Missense_Mutation_p.A435V|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A435V			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	435					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GCCAATTTGGCCTGTTCCATC	0.473000													12	18					0	0	0.105934	0	0
OR9I1	219954	broad.mit.edu	37	11	57886223	57886223	+	Missense_Mutation	SNP	C	C	T	rs143742477		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:57886223C>T	ENST00000302610.1	-	1	693	c.694G>A	c.(694-696)Ggt>Agt	p.G232S	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				GCCCTGCCACCTGAAGACTTC	0.463000													34	46					0	0	0.193644	0	0
CD48	962	broad.mit.edu	37	1	160681540	160681540	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:160681540C>T	ENST00000368045.3	-	1	53	c.14G>A	c.(13-15)gGt>gAt	p.G5D	CD48_ENST00000368046.3_Missense_Mutation_p.G5D			P09326	CD48_HUMAN	CD48 molecule	5					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CGAATCCCAACCTCTGGAGCA	0.507000													13	87					0	0	0.093190	0	0
AMER1	139285	broad.mit.edu	37	X	63412182	63412182	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:63412182C>A	ENST00000330258.3	-	2	1257	c.985G>T	c.(985-987)Ggt>Tgt	p.G329C	AMER1_ENST00000403336.1_Missense_Mutation_p.G329C|AMER1_ENST00000374869.3_Missense_Mutation_p.G329C	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									ATTATGTCACCACAACCTGTC	0.532000													46	103					1.6237e-14	2.20331e-14	0.131918	1	0
PRNP	5621	broad.mit.edu	37	20	4680012	4680012	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:4680012A>G	ENST00000379440.4	+	2	433	c.146A>G	c.(145-147)tAc>tGc	p.Y49C	PRNP_ENST00000430350.2_Missense_Mutation_p.Y49C	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	49	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	GGCAACCGCTACCCACCTCAG	0.701000													10	33					0	0	0.093190	0	0
FABP5	2171	broad.mit.edu	37	8	82195599	82195599	+	Splice_Site	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:82195599A>G	ENST00000396359.1	+	2	447		c.e2-1		FABP5_ENST00000297258.6_Splice_Site			Q01469	FABP5_HUMAN	fatty acid binding protein 5 (psoriasis-associated)						epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity			large_intestine(1)|lung(3)	4	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)			AACATTCTACAGGAGTGGGAA	0.368000													4	35					0	0	0.150653	0	0
CFI	3426	broad.mit.edu	37	4	110687940	110687940	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:110687940C>A	ENST00000394634.2	-	2	305	c.98G>T	c.(97-99)tGc>tTc	p.C33F	CFI_ENST00000512148.1_Missense_Mutation_p.C33F|CFI_ENST00000394635.3_Missense_Mutation_p.C33F|CFI_ENST00000510800.1_Missense_Mutation_p.C33F	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	33					complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TTTTGCTAAGCACTTTTTCTC	0.393000													9	62					7.48243e-07	8.89239e-07	0.058154	1	0
TMEM132D	121256	broad.mit.edu	37	12	129559133	129559133	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:129559133G>T	ENST00000422113.2	-	9	2913	c.2587C>A	c.(2587-2589)Cag>Aag	p.Q863K	TMEM132D_ENST00000389441.4_Missense_Mutation_p.Q401K	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	863						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCTTCTTCTGCAGGATGGAC	0.577000													15	56					6.31663e-08	7.73891e-08	0.132662	1	0
COL6A6	131873	broad.mit.edu	37	3	130284242	130284242	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:130284242C>T	ENST00000358511.6	+	3	1097	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	COL6A6_ENST00000453409.2_Nonsense_Mutation_p.R356*	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	356	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGTTAACCTCCGACGGGAGGG	0.567000													51	141					0	0	0.139131	0	0
TAAR6	319100	broad.mit.edu	37	6	132891805	132891805	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:132891805T>C	ENST00000275198.1	+	1	345	c.345T>C	c.(343-345)ttT>ttC	p.F115F		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	115						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		ATGTGGCATTTTGTTACTCTT	0.488000													76	105					0	0	0.139131	0	0
MYO5A	4644	broad.mit.edu	37	15	52611498	52611498	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:52611498C>A	ENST00000399231.3	-	38	5161	c.4918G>T	c.(4918-4920)Ggg>Tgg	p.G1640W	MYO5A_ENST00000399233.2_Missense_Mutation_p.G1637W|MYO5A_ENST00000356338.6_Missense_Mutation_p.G1613W|MYO5A_ENST00000358212.6_Missense_Mutation_p.G1665W|MYO5A_ENST00000553916.1_Missense_Mutation_p.G1638W	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1640	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GGCTTCACCCCAGACACGCCC	0.532000													6	66					3.09899e-07	3.71477e-07	0.047766	1	0
GCM2	9247	broad.mit.edu	37	6	10877569	10877569	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:10877569G>C	ENST00000379491.4	-	2	294	c.147C>G	c.(145-147)atC>atG	p.I49M	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	49					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding	p.I49M(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CGCTGCTGTAGATGAAGCGCA	0.567000													3	47					0	0	0.150653	0	0
SLC25A13	10165	broad.mit.edu	37	7	95750584	95750584	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:95750584C>A	ENST00000416240.2	-	18	2140	c.1950G>T	c.(1948-1950)ggG>ggT	p.G650G	SLC25A13_ENST00000542654.1_Silent_p.G541G|SLC25A13_ENST00000494085.1_5'UTR|SLC25A13_ENST00000265631.5_Silent_p.G649G	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	649					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TGTTTTCAATCCCTGCAAATG	0.493000													28	70					1.2476e-16	1.76637e-16	0.116897	1	0
AGL	178	broad.mit.edu	37	1	100376370	100376370	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:100376370G>A	ENST00000294724.4	+	28	4281	c.3803G>A	c.(3802-3804)aGa>aAa	p.R1268K	AGL_ENST00000370161.2_Missense_Mutation_p.R1252K|AGL_ENST00000370163.3_Missense_Mutation_p.R1268K|AGL_ENST00000370165.3_Missense_Mutation_p.R1268K|AGL_ENST00000361915.3_Missense_Mutation_p.R1268K|AGL_ENST00000361522.4_Missense_Mutation_p.R1251K|AGL_ENST00000361302.3_Missense_Mutation_p.R1252K	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1268					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GAAAGTGACAGAGCTAGAAAC	0.373000													7	40					0	0	0.047766	0	0
CCDC83	220047	broad.mit.edu	37	11	85630467	85630467	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:85630467G>C	ENST00000280245.4	+	12	1761	c.1249G>C	c.(1249-1251)Gag>Cag	p.E417Q	CCDC83_ENST00000376067.1_Missense_Mutation_p.E286Q|RP11-90K17.2_ENST00000531414.1_RNA|CCDC83_ENST00000342404.3_Missense_Mutation_p.E386Q	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	386										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TCATTTTCAAGAGAAGGAAAT	0.418000													12	94					0	0	0.119110	0	0
GPRC5B	51704	broad.mit.edu	37	16	19873247	19873247	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:19873247C>G	ENST00000300571.2	-	3	1270	c.1079G>C	c.(1078-1080)aGt>aCt	p.S360T	GPRC5B_ENST00000537135.1_Missense_Mutation_p.S386T|GPRC5B_ENST00000535671.1_Missense_Mutation_p.S360T|GPRC5B_ENST00000569847.1_Missense_Mutation_p.S360T|GPRC5B_ENST00000569479.1_Missense_Mutation_p.S360T	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	360										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CAAGCTGCCACTGGGTCTTTT	0.527000													5	25					0	0	0.217242	0	0
MMP26	56547	broad.mit.edu	37	11	5009450	5009450	+	Silent	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:5009450C>G	ENST00000380390.1	+	2	225	c.9C>G	c.(7-9)ctC>ctG	p.L3L	MMP26_ENST00000300762.1_Silent_p.L3L|MMP26_ENST00000477339.1_Intron			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	3					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCATGCAGCTCGTCATCTTAA	0.493000											OREG0003716	type=REGULATORY REGION|Gene=MMP26|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	33	55					0	0	0.163468	0	0
XKRX	402415	broad.mit.edu	37	X	100169469	100169469	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:100169469T>C	ENST00000328526.5	-	3	1812	c.1247A>G	c.(1246-1248)cAg>cGg	p.Q416R	XKRX_ENST00000372956.2_Missense_Mutation_p.Q403R|XKRX_ENST00000468904.1_3'UTR	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	403						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						ATGCAAGTACTGGAAGAAAAG	0.448000													29	88					0	0	0.134883	0	0
DAB1	1600	broad.mit.edu	37	1	57535035	57535035	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:57535035G>C	ENST00000371236.2	-	8	924	c.661C>G	c.(661-663)Cag>Gag	p.Q221E	DAB1_ENST00000414851.2_Intron|DAB1_ENST00000420954.2_Intron|DAB1_ENST00000371231.1_Missense_Mutation_p.Q221E|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371234.4_Missense_Mutation_p.Q221E|DAB1_ENST00000439789.2_Intron			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	221					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TTTTATACCTGATAAATGTTT	0.428000													20	118					0	0	0.234183	0	0
MUC16	94025	broad.mit.edu	37	19	9088114	9088114	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:9088114C>A	ENST00000397910.4	-	1	3904	c.3701G>T	c.(3700-3702)gGg>gTg	p.G1234V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1234	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAAGTCCCCCTTCTGATGC	0.502000													64	734					1.77791e-30	2.65968e-30	0.139131	1	0
OR4D1	26689	broad.mit.edu	37	17	56233444	56233444	+	Silent	SNP	G	G	A	rs78424437	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:56233444G>A	ENST00000268912.5	+	1	951	c.930G>A	c.(928-930)gaG>gaA	p.E310E		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTTGCAGGGAGTAAACTTTAA	0.388000													6	64					0	0	0.217242	0	0
TGM5	9333	broad.mit.edu	37	15	43552279	43552279	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:43552279A>G	ENST00000220420.5	-	3	414	c.407T>C	c.(406-408)tTc>tCc	p.F136S	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	136					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	AAGCAGGATGAACTCCCCTAG	0.607000													3	90					0	0	0.115264	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476711	110476711	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:110476711C>T	ENST00000378402.5	+	49	7754	c.7650C>T	c.(7648-7650)acC>acT	p.T2550T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2550					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGCAAAGTACCAGTCTTCTGA	0.418000										HNSCC(38;0.096)			36	46					0	0	0.225048	0	0
WDR17	116966	broad.mit.edu	37	4	177071009	177071009	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:177071009A>T	ENST00000393643.2	+	14	2201	c.1949A>T	c.(1948-1950)gAc>gTc	p.D650V	WDR17_ENST00000280190.4_Missense_Mutation_p.D674V|WDR17_ENST00000507824.2_Missense_Mutation_p.D657V|WDR17_ENST00000508596.1_Missense_Mutation_p.D650V	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	674										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TGCTCCCGTGACTCTACAGTG	0.403000													17	56					0	0	0.160694	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941649	13941649	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:13941649G>A	ENST00000254323.2	+	13	2944	c.2755G>A	c.(2755-2757)Gca>Aca	p.A919T	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.A753T	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	919							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CCTGGACGCGGCAGTCACCGC	0.701000													23	37					0	0	0.083992	0	0
TP53	7157	broad.mit.edu	37	17	7578258	7578258	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:7578258C>A	ENST00000420246.2	-	6	723	c.591G>T	c.(589-591)gtG>gtT	p.V197V	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Silent_p.V197V|TP53_ENST00000269305.4_Silent_p.V197V|TP53_ENST00000413465.2_Silent_p.V197V|TP53_ENST00000445888.2_Silent_p.V197V|TP53_ENST00000455263.2_Silent_p.V197V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	197	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> E (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.V197V(2)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AATTTCCTTCCACTCGGATAA	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	54					1.75199e-13	2.32065e-13	0.125774	1	0
OR6C75	390323	broad.mit.edu	37	12	55759462	55759462	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:55759462A>G	ENST00000343399.3	+	1	568	c.568A>G	c.(568-570)Act>Gct	p.T190A		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						TTGCACAAACACTCACTTTCT	0.408000													10	102					0	0	0.069234	0	0
C1orf68	100129271	broad.mit.edu	37	1	152692118	152692118	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:152692118A>C	ENST00000368775.2	+	1	121	c.121A>C	c.(121-123)Act>Cct	p.T41P		NM_001024679.2	NP_001019850.1	Q5T750	XP32_HUMAN	chromosome 1 open reading frame 68	41	Cys-rich.				epidermis development					NS(1)|breast(1)|lung(2)|prostate(1)|stomach(3)	8						CCAGACCCAAACTGTCTGTGT	0.547000													3	35					0	0	0.115264	0	0
ZNF462	58499	broad.mit.edu	37	9	109690045	109690045	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:109690045C>T	ENST00000277225.5	+	3	4141	c.3852C>T	c.(3850-3852)atC>atT	p.I1284I	ZNF462_ENST00000457913.1_Silent_p.I1284I|ZNF462_ENST00000441147.2_Silent_p.I129I			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1284					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GGAAGCATATCAAGAAAGACC	0.522000													382	483					0	0	0.139131	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951006	235951006	+	Missense_Mutation	SNP	G	G	T	rs148242042		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:235951006G>T	ENST00000409212.1	+	4	2100	c.1593G>T	c.(1591-1593)ttG>ttT	p.L531F	SH3BP4_ENST00000392011.2_Missense_Mutation_p.L531F|SH3BP4_ENST00000344528.4_Missense_Mutation_p.L531F			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	531					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AGTTCGTTTTGTCCAGGCCCC	0.587000													9	22					1.12685e-05	1.28419e-05	0.047766	1	0
KAL1	3730	broad.mit.edu	37	X	8503728	8503728	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:8503728C>T	ENST00000262648.3	-	12	1895	c.1746G>A	c.(1744-1746)atG>atA	p.M582I	KAL1_ENST00000481896.1_5'UTR	NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	582	Fibronectin type-III 4.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GAAACCCAGTCATGGGCTGAT	0.498000													9	24					0	0	0.047766	0	0
CYP27B1	1594	broad.mit.edu	37	12	58156960	58156960	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:58156960C>G	ENST00000228606.4	-	9	1701	c.1492G>C	c.(1492-1494)Gaa>Caa	p.E498Q		NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	498					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	ATGCTCCTTTCAGGTACCAGG	0.488000													7	22					0	0	0.029380	0	0
ZBTB18	10472	broad.mit.edu	37	1	244218033	244218033	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:244218033G>T	ENST00000358704.4	+	2	1106	c.957G>T	c.(955-957)gaG>gaT	p.E319D		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		TACAGTATGAGCCGGCCCATC	0.527000													22	42					3.01185e-09	3.75635e-09	0.091800	1	0
SSH2	85464	broad.mit.edu	37	17	27999144	27999144	+	Silent	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:27999144A>G	ENST00000269033.3	-	8	688	c.537T>C	c.(535-537)tcT>tcC	p.S179S	SSH2_ENST00000540801.1_Silent_p.S206S|RP11-68I3.2_ENST00000581474.1_RNA	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	179					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCTGTAGTGCAGACCTGAAAG	0.443000													3	24					0	0	0.150653	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227213800	227213800	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:227213800C>G	ENST00000366769.3	-	30	5672	c.4381G>C	c.(4381-4383)Gat>Cat	p.D1461H	CDC42BPA_ENST00000366765.3_Missense_Mutation_p.D1474H|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.D1496H|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.D1441H|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.D1380H|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.D1433H|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.D1461H	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1474	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GAGTTCACATCAAAGATATCA	0.398000													3	52					0	0	0.150653	0	0
NLRP8	126205	broad.mit.edu	37	19	56490758	56490758	+	Splice_Site	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:56490758A>C	ENST00000291971.3	+	9	2947		c.e9-1		NLRP8_ENST00000590542.1_Splice_Site	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8							cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCTGTGTCACAGGCTGGAAAA	0.517000													8	70					0	0	0.080935	0	0
PLA2G12A	81579	broad.mit.edu	37	4	110639891	110639891	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:110639891C>A	ENST00000243501.5	-	2	500	c.233G>T	c.(232-234)gGt>gTt	p.G78V	PLA2G12A_ENST00000502283.1_Missense_Mutation_p.G78V|PLA2G12A_ENST00000502772.1_5'UTR	NM_030821.4	NP_110448.2	Q9BZM1	PG12A_HUMAN	phospholipase A2, group XIIA	78					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			kidney(1)|lung(1)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000268)		GGGTTTATAACCATAACGTGG	0.308000													9	38					9.70103e-10	1.22924e-09	0.069234	1	0
TECTA	7007	broad.mit.edu	37	11	121028887	121028887	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:121028887A>G	ENST00000392793.1	+	14	4914	c.4643A>G	c.(4642-4644)tAc>tGc	p.Y1548C	TECTA_ENST00000264037.2_Missense_Mutation_p.Y1548C			O75443	TECTA_HUMAN	tectorin alpha	1548	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTCTACTTCTACATTAACGAA	0.532000													41	201					0	0	0.111260	0	0
TTN	7273	broad.mit.edu	37	2	179483162	179483162	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:179483162T>A	ENST00000589042.1	-	252	47247	c.47023A>T	c.(47023-47025)Agc>Tgc	p.S15675C	TTN_ENST00000342992.6_Missense_Mutation_p.S13107C|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S6735C|TTN_ENST00000342175.6_Missense_Mutation_p.S6802C|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S6610C|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S14034C|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14034	Ig-like 98.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGCAAGGCTCACTTCACCA	0.418000													25	61					0	0	0.076483	0	0
CSN3	1448	broad.mit.edu	37	4	71114958	71114958	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:71114958C>G	ENST00000304954.3	+	4	417	c.331C>G	c.(331-333)Cca>Gca	p.P111A		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	111						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						GGTACGTCGCCCAAACCTGCA	0.468000													9	42					0	0	0.058154	0	0
PLXNA2	5362	broad.mit.edu	37	1	208315681	208315681	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:208315681T>G	ENST00000367033.3	-	4	2256	c.1499A>C	c.(1498-1500)gAg>gCg	p.E500A		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	500	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TACCTGTCTCTCAGACATGAC	0.498000													4	52					0	0	0.184627	0	0
OR10J5	127385	broad.mit.edu	37	1	159505395	159505395	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:159505395T>C	ENST00000334857.2	-	1	447	c.403A>G	c.(403-405)Atc>Gtc	p.I135V		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TTGCTCATGATGACAGTGTAT	0.483000													28	113					0	0	0.134883	0	0
CNTN5	53942	broad.mit.edu	37	11	100169965	100169965	+	Silent	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:100169965T>A	ENST00000524871.1	+	20	2747	c.2457T>A	c.(2455-2457)cgT>cgA	p.R819R	CNTN5_ENST00000528682.1_Silent_p.R819R|CNTN5_ENST00000418526.2_Silent_p.R745R|CNTN5_ENST00000279463.3_Silent_p.R819R|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Silent_p.R819R	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	819	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATGGAACACGTGGCTGGAAGG	0.408000													10	37					0	0	0.058154	0	0
EYA1	2138	broad.mit.edu	37	8	72127698	72127698	+	Silent	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:72127698T>G	ENST00000340726.3	-	16	2160	c.1521A>C	c.(1519-1521)ccA>ccC	p.P507P	EYA1_ENST00000388743.2_Silent_p.P506P|EYA1_ENST00000388740.3_Silent_p.P474P|EYA1_ENST00000419131.1_Silent_p.P472P|EYA1_ENST00000388741.2_Silent_p.P473P|EYA1_ENST00000388742.4_Silent_p.P507P|EYA1_ENST00000303824.7_Silent_p.P501P	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	507					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TCGCCAATGCTGGGATGAGCT	0.333000													24	38					0	0	0.099896	0	0
NAV3	89795	broad.mit.edu	37	12	78444626	78444626	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:78444626C>A	ENST00000397909.2	+	11	2388	c.2215C>A	c.(2215-2217)Ccc>Acc	p.P739T	NAV3_ENST00000228327.6_Missense_Mutation_p.P739T|NAV3_ENST00000266692.7_Missense_Mutation_p.P739T|NAV3_ENST00000536525.2_Missense_Mutation_p.P739T			Q8IVL0	NAV3_HUMAN	neuron navigator 3	739						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCGACCCACCCCCATGACCTG	0.542000										HNSCC(70;0.22)			40	52					2.26627e-22	3.30127e-22	0.098360	1	0
SEMA3D	223117	broad.mit.edu	37	7	84666241	84666241	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:84666241C>A	ENST00000284136.6	-	10	1198	c.1155G>T	c.(1153-1155)caG>caT	p.Q385H	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	385	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TCCCATCATACTGCACCCAAC	0.373000													10	59					1.08611e-07	1.32481e-07	0.080935	1	0
TTN	7273	broad.mit.edu	37	2	179604758	179604758	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:179604758C>A	ENST00000589042.1	-	48	13426	c.13202G>T	c.(13201-13203)cGg>cTg	p.R4401L	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R4163L|TTN_ENST00000342175.6_Missense_Mutation_p.R4230L|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R4038L|TTN_ENST00000591111.1_Missense_Mutation_p.R4084L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4084	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCAAAGCCCGGCAGATTTG	0.478000													32	62					5.45727e-16	7.64845e-16	0.134883	1	0
CCT6A	908	broad.mit.edu	37	7	56126388	56126388	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:56126388A>G	ENST00000275603.4	+	8	1180	c.961A>G	c.(961-963)Atg>Gtg	p.M321V	CCT6A_ENST00000335503.3_Missense_Mutation_p.M276V|CCT6A_ENST00000540286.1_Missense_Mutation_p.M290V	NM_001762.3	NP_001753.1	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A (zeta 1)	321					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	15	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AAGGAGAAATATGGAGAGGTA	0.323000													16	53					0	0	0.204396	0	0
FANCM	57697	broad.mit.edu	37	14	45633586	45633586	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:45633586G>T	ENST00000267430.5	+	10	1691	c.1606G>T	c.(1606-1608)Ggt>Tgt	p.G536C	FANCM_ENST00000556036.1_Missense_Mutation_p.G536C|FANCM_ENST00000542564.2_Missense_Mutation_p.G510C	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	536	Helicase C-terminal.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TCGTGACGGTGGTTACAACAC	0.368000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	25					0.00116845	0.00124231	0.217242	1	0
FRMD4A	55691	broad.mit.edu	37	10	13779903	13779903	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:13779903C>A	ENST00000357447.2	-	12	1068	c.700G>T	c.(700-702)Ggc>Tgc	p.G234C	FRMD4A_ENST00000342409.2_Missense_Mutation_p.G250C|RP11-353M9.1_ENST00000449462.1_RNA|FRMD4A_ENST00000358621.4_Missense_Mutation_p.G219C|FRMD4A_ENST00000378503.1_Missense_Mutation_p.G234C	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	234	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						TAGCTCAGGCCCAGCCACCAT	0.468000													8	26					0.00307968	0.00323716	0.038147	1	0
OR2G6	391211	broad.mit.edu	37	1	248685282	248685282	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:248685282G>A	ENST00000343414.4	+	1	367	c.335G>A	c.(334-336)tGt>tAt	p.C112Y		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCGTCTGAGTGTATTCTCTTG	0.552000													15	129					0	0	0.132662	0	0
SLC26A5	375611	broad.mit.edu	37	7	103048344	103048344	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:103048344C>T	ENST00000306312.3	-	8	1103	c.842G>A	c.(841-843)aGa>aAa	p.R281K	SLC26A5_ENST00000432958.2_Missense_Mutation_p.R281K|SLC26A5_ENST00000393727.1_Missense_Mutation_p.R281K|SLC26A5_ENST00000339444.6_Missense_Mutation_p.R281K|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393723.1_Missense_Mutation_p.R281K|SLC26A5_ENST00000393735.2_Missense_Mutation_p.R281K|SLC26A5_ENST00000356767.4_Missense_Mutation_p.R281K|SLC26A5_ENST00000393729.1_Missense_Mutation_p.R244K|SLC26A5_ENST00000393730.1_Missense_Mutation_p.R281K	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	281					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CTCTTTAAATCTCTCATTAAA	0.453000													14	89					0	0	0.119110	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8224231	8224231	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:8224231A>G	ENST00000361926.3	+	16	2556	c.2446A>G	c.(2446-2448)Agg>Ggg	p.R816G	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.R816G	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	816					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						ACACGAAAGGAGGAGGCACCT	0.617000													13	32					0	0	0.105934	0	0
RGS9	8787	broad.mit.edu	37	17	63221442	63221442	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:63221442G>A	ENST00000449996.3	+	18	1793	c.1721G>A	c.(1720-1722)cGc>cAc	p.R574H	RGS9_ENST00000443584.3_Missense_Mutation_p.R574H|RGS9_ENST00000262406.9_Missense_Mutation_p.R577H	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	577				P -> L (in Ref. 7; AAC25430).	intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity	p.R577H(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						CCTAAGGCCCGCATGGCTCTG	0.682000													4	191					0	0	0.184627	0	0
ARSK	153642	broad.mit.edu	37	5	94890989	94890989	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:94890989C>T	ENST00000380009.4	+	1	212	c.7C>T	c.(7-9)Ctg>Ttg	p.L3L	ARSK_ENST00000504763.1_Silent_p.L3L	NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	3						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		GGCGATGCTACTGCTGTGGGT	0.682000													8	10					0	0	0.080935	0	0
ZNF233	353355	broad.mit.edu	37	19	44778566	44778566	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:44778566G>A	ENST00000391958.2	+	5	1880	c.1753G>A	c.(1753-1755)Gtc>Atc	p.V585I	ZNF233_ENST00000334152.1_Missense_Mutation_p.V567I|ZNF233_ENST00000592581.1_3'UTR|ZNF235_ENST00000589799.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				CCATCAGAGAGTCCACACAGG	0.453000													25	83					0	0	0.099896	0	0
KIAA1239	57495	broad.mit.edu	37	4	37440761	37440761	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:37440761G>A	ENST00000309447.5	+	6	1893	c.1045G>A	c.(1045-1047)Gac>Aac	p.D349N		NM_001144990.1	NP_001138462.1	Q9ULI1	K1239_HUMAN	KIAA1239	349										breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(2)|skin(2)	16						ATTTTATGAGGACATGATTGA	0.338000													3	12					0	0	0.115264	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500350	90500350	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:90500350G>T	ENST00000325643.5	+	4	1014	c.948G>T	c.(946-948)tgG>tgT	p.W316C		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCACCACCTGGGGCCTCTCCA	0.627000													11	40					1.5842e-08	1.96257e-08	0.105934	1	0
OR1N1	138883	broad.mit.edu	37	9	125289495	125289495	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:125289495G>A	ENST00000304880.2	-	1	77	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGAAAATTCCGAAGAGGGACT	0.498000													7	104					0	0	0.038147	0	0
UHRF2	115426	broad.mit.edu	37	9	6433943	6433943	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:6433943C>T	ENST00000276893.5	+	3	582	c.414C>T	c.(412-414)gtC>gtT	p.V138V	RP11-307L3.4_ENST00000411561.1_RNA	NM_152896.2	NP_690856.1	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	138					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		CCAGAGATGTCGGCCTTGGTG	0.383000													12	22					0	0	0.093190	0	0
DOCK1	1793	broad.mit.edu	37	10	129218009	129218009	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:129218009G>T	ENST00000280333.6	+	46	4818	c.4709G>T	c.(4708-4710)tGg>tTg	p.W1570L		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1570	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CTGATTGCTTGGCAGGTAAAG	0.562000													3	8					0.00024832	0.000270761	0.150653	1	0
ETV3L	440695	broad.mit.edu	37	1	157069071	157069071	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:157069071T>C	ENST00000454449.2	-	2	442	c.158A>G	c.(157-159)gAg>gGg	p.E53G		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	53						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				ATGGCGGAACTCTTCCTTCTG	0.602000													22	62					0	0	0.163468	0	0
SCN3A	6328	broad.mit.edu	37	2	165947561	165947561	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:165947561C>A	ENST00000360093.3	-	28	5593	c.5102G>T	c.(5101-5103)tGc>tTc	p.C1701F	SCN3A_ENST00000283254.7_Missense_Mutation_p.C1701F|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000540861.1_Missense_Mutation_p.C184F|SCN3A_ENST00000409101.3_Missense_Mutation_p.C1652F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1701						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTGGAACAAGCAGATCATGCT	0.453000													35	188					4.34311e-12	5.67159e-12	0.183431	1	0
PTPN12	5782	broad.mit.edu	37	7	77256164	77256164	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:77256164A>T	ENST00000248594.6	+	13	1440	c.1168A>T	c.(1168-1170)Aag>Tag	p.K390*	PTPN12_ENST00000415482.2_Nonsense_Mutation_p.K271*|PTPN12_ENST00000435495.2_Nonsense_Mutation_p.K260*	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	390	Interaction with TGFB1I1 (By similarity).					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						ATACCATCCAAAGCCAGTGTT	0.438000													7	43					0	0	0.029380	0	0
PRSS54	221191	broad.mit.edu	37	16	58318599	58318599	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:58318599G>T	ENST00000219301.4	-	6	943	c.549C>A	c.(547-549)gtC>gtA	p.V183V	PRSS54_ENST00000543437.1_Silent_p.V84V|PRSS54_ENST00000567164.1_Silent_p.V183V|PRSS54_ENST00000563336.1_5'UTR	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	183	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTTTCCTCAGGACACTCATCG	0.483000													9	45					0.00621372	0.00647019	0.058154	1	0
MUC16	94025	broad.mit.edu	37	19	9089538	9089538	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:9089538G>C	ENST00000397910.4	-	1	2480	c.2277C>G	c.(2275-2277)atC>atG	p.I759M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	759	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTTTGTTGAGATTTCAGGAG	0.473000													48	481					0	0	0.139131	0	0
FIBIN	387758	broad.mit.edu	37	11	27016184	27016184	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:27016184C>G	ENST00000318627.2	+	1	557	c.111C>G	c.(109-111)ttC>ttG	p.F37L		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	37						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						ACCACTACTTCGTGCCCGATG	0.582000													4	36					0	0	0.184627	0	0
SHANK2	22941	broad.mit.edu	37	11	70333298	70333298	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:70333298T>C	ENST00000338508.4	-	32	3102	c.3103A>G	c.(3103-3105)Atc>Gtc	p.I1035V	SHANK2_ENST00000423696.2_Missense_Mutation_p.I655V|SHANK2_ENST00000449833.2_Missense_Mutation_p.I439V|SHANK2_ENST00000409161.1_Missense_Mutation_p.I438V			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	655					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTCACGATGATGGTCGGGATA	0.672000													4	16					0	0	0.184627	0	0
MERTK	10461	broad.mit.edu	37	2	112754908	112754908	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:112754908G>C	ENST00000295408.4	+	10	1716	c.1459G>C	c.(1459-1461)Gat>Cat	p.D487H	MERTK_ENST00000421804.2_Missense_Mutation_p.D487H|MERTK_ENST00000409780.1_Missense_Mutation_p.D311H			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	487					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.D487Y(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						AGGTTGGGTAGATTATGCCCC	0.428000													20	149					0	0	0.234183	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610672	50610672	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:50610672C>A	ENST00000371824.1	+	2	310	c.53C>A	c.(52-54)tCc>tAc	p.S18Y	ELAVL4_ENST00000448907.2_Missense_Mutation_p.S21Y|ELAVL4_ENST00000371821.1_Missense_Mutation_p.S23Y|ELAVL4_ENST00000371827.1_Missense_Mutation_p.S18Y|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371823.4_Missense_Mutation_p.S18Y|ELAVL4_ENST00000371819.1_Missense_Mutation_p.S23Y|ELAVL4_ENST00000357083.4_Missense_Mutation_p.S35Y			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	18					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						GGTCCGACATCCAATACAAGC	0.423000													14	85					7.93312e-07	9.40787e-07	0.119110	1	0
C5AR1	728	broad.mit.edu	37	19	47823367	47823367	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:47823367C>G	ENST00000355085.3	+	2	355	c.333C>G	c.(331-333)atC>atG	p.I111M		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	111					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CCTGCAGCATCCTGCCCTCCC	0.617000													4	39					0	0	0.150653	0	0
CDHR3	222256	broad.mit.edu	37	7	105660902	105660902	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:105660902G>C	ENST00000542731.1	+	13	1845	c.1737G>C	c.(1735-1737)ctG>ctC	p.L579L	CDHR3_ENST00000317716.9_Silent_p.L579L|CDHR3_ENST00000343407.5_Intron|CDHR3_ENST00000470188.1_Intron|CDHR3_ENST00000478080.1_Silent_p.L491L			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	579	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CAGTGGATCTGAAAGTTGGCA	0.428000													32	117					0	0	0.144211	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204854	5204854	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:5204854C>A	ENST00000334314.3	-	2	299	c.223G>T	c.(223-225)Ggt>Tgt	p.G75C						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TTGACGGTACCATCAGCGATC	0.423000													133	144					1.31213e-79	2.00615e-79	0.139131	1	0
MC4R	4160	broad.mit.edu	37	18	58039336	58039336	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:58039336T>A	ENST00000299766.3	-	1	665	c.247A>T	c.(247-249)Atc>Ttc	p.I83F		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	83					feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				AAGCTGCAGATGAAAAAGTAC	0.438000													74	80					0	0	0.139131	0	0
TRRAP	8295	broad.mit.edu	37	7	98564703	98564703	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:98564703A>C	ENST00000359863.4	+	49	7404	c.7195A>C	c.(7195-7197)Atg>Ctg	p.M2399L	TRRAP_ENST00000355540.3_Missense_Mutation_p.M2381L|TRRAP_ENST00000446306.3_Missense_Mutation_p.M2381L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2399					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCTTGTGAAGATGATGACTTA	0.353000													9	64					0	0	0.047766	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913448	39913448	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:39913448C>T	ENST00000425673.1	+	16	1992	c.1667C>T	c.(1666-1668)gCc>gTc	p.A556V	PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.A526V|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.A585V|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	585					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACATTCCAAGCCCTGCCCAGC	0.612000													16	46					0	0	0.175082	0	0
OR51A7	119687	broad.mit.edu	37	11	4928916	4928916	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:4928916G>T	ENST00000359350.4	+	1	317	c.317G>T	c.(316-318)gGa>gTa	p.G106V	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCATTCATGGATTCACTGTC	0.433000													29	61					2.12542e-12	2.78209e-12	0.116897	1	0
PIK3CG	5294	broad.mit.edu	37	7	106508152	106508152	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:106508152G>T	ENST00000359195.3	+	2	456	c.146G>T	c.(145-147)cGc>cTc	p.R49L	PIK3CG_ENST00000440650.2_Missense_Mutation_p.R49L|PIK3CG_ENST00000496166.1_Missense_Mutation_p.R49L	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	49					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						ACCAGCCAGCGCAAATGCAAG	0.672000													9	48					2.17888e-05	2.45289e-05	0.058154	1	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709637	22709637	+	RNA	SNP	T	T	G	rs140467724	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:22709637T>G	ENST00000314246.8	-	0	1147																											CCCATCTGGTTTTTGAGTTTG	0.547000													3	108					0	0	0.115264	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15428	15428	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrM:15428G>A	ENST00000361789.2	+	1	682	c.682G>A	c.(682-684)Gac>Aac	p.228_228insN						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						ACACAATCAAAGACGCCCTCG	0.478000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	12	447					0	0	0.119110	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124685	26124685	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:26124685G>C	ENST00000602637.1	+	1	255	c.225G>C	c.(223-225)aaG>aaC	p.K75N	HIST1H2AC_ENST00000377791.2_Missense_Mutation_p.K75N			Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	75					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(5)	12						GCGACAACAAGAAGACTCGCA	0.662000													4	102					0	0	0.150653	0	0
OR4C11	219429	broad.mit.edu	37	11	55370922	55370922	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:55370922C>A	ENST00000302231.4	-	1	952	c.928G>T	c.(928-930)Gga>Tga	p.G310*		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						TCAATTTATCCTTTGTTTTCT	0.373000													11	12					3.86212e-05	4.31283e-05	0.069234	1	0
PDE8B	8622	broad.mit.edu	37	5	76708954	76708954	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:76708954C>A	ENST00000264917.5	+	17	1776	c.1731C>A	c.(1729-1731)ggC>ggA	p.G577G	PDE8B_ENST00000342343.4_Silent_p.G557G|PDE8B_ENST00000346042.3_Silent_p.G480G|PDE8B_ENST00000333194.4_Silent_p.G522G|PDE8B_ENST00000340978.3_Silent_p.G530G|PDE8B_ENST00000505283.1_Silent_p.G42G	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	577					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TTTATCTGGGCTTAAAGGTCT	0.443000													27	150					1.08312e-15	1.5066e-15	0.144211	1	0
BRWD1	54014	broad.mit.edu	37	21	40570870	40570870	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr21:40570870G>C	ENST00000342449.3	-	40	5550	c.5472C>G	c.(5470-5472)gaC>gaG	p.D1824E	BRWD1_ENST00000333229.2_Missense_Mutation_p.D1824E|BRWD1_ENST00000380800.3_Missense_Mutation_p.D1824E	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1824					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CAGATTCAGAGTCTTCTGAGT	0.383000													33	61					0	0	0.225048	0	0
AAK1	22848	broad.mit.edu	37	2	69769785	69769785	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:69769785A>C	ENST00000409085.4	-	5	780	c.404T>G	c.(403-405)gTa>gGa	p.V135G	AAK1_ENST00000409068.1_Missense_Mutation_p.V135G|AAK1_ENST00000470281.1_5'UTR|AAK1_ENST00000406297.3_Missense_Mutation_p.V135G	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	135	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						CATCAGGTTTACCACCTGGCC	0.488000													37	275					0	0	0.124865	0	0
TRIM2	23321	broad.mit.edu	37	4	154237007	154237007	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:154237007C>G	ENST00000338700.5	+	8	1703	c.1638C>G	c.(1636-1638)ttC>ttG	p.F546L	TRIM2_ENST00000437508.2_Missense_Mutation_p.F519L	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	519						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		ATGGCCAGTTCAAAAGTCGTT	0.483000													12	42					0	0	0.105934	0	0
SLC7A14	57709	broad.mit.edu	37	3	170185069	170185069	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:170185069T>A	ENST00000231706.4	-	8	2405	c.2090A>T	c.(2089-2091)gAc>gTc	p.D697V	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	697						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GTCATCCACGTCGTAGCGTTG	0.562000													4	60					0	0	0.150653	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175707	143175707	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:143175707C>G	ENST00000408916.1	+	1	742	c.742C>G	c.(742-744)Ctg>Gtg	p.L248V	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	248					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCTGTCCTTTCTGTCCCTGAT	0.512000													49	91					0	0	0.139131	0	0
ATF2	1386	broad.mit.edu	37	2	175979488	175979488	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:175979488G>A	ENST00000264110.2	-	8	854	c.556C>T	c.(556-558)Cag>Tag	p.Q186*	ATF2_ENST00000392543.2_Intron|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000392544.1_Nonsense_Mutation_p.Q186*|ATF2_ENST00000487334.2_Nonsense_Mutation_p.Q168*|ATF2_ENST00000426833.3_Nonsense_Mutation_p.Q168*|ATF2_ENST00000409833.1_Nonsense_Mutation_p.Q186*|ATF2_ENST00000409635.1_Nonsense_Mutation_p.Q128*|ATF2_ENST00000345739.5_Nonsense_Mutation_p.Q128*|ATF2_ENST00000538946.1_Nonsense_Mutation_p.Q168*|ATF2_ENST00000409437.1_Intron	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	186					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			ACTGCCTGCTGAATAATTACA	0.448000													18	100					0	0	0.219247	0	0
NRAP	4892	broad.mit.edu	37	10	115389428	115389428	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:115389428C>A	ENST00000369358.4	-	19	2227	c.1983G>T	c.(1981-1983)agG>agT	p.R661S	NRAP_ENST00000369360.3_Missense_Mutation_p.R626S|NRAP_ENST00000360478.3_Missense_Mutation_p.R618S|NRAP_ENST00000359988.3_Missense_Mutation_p.R653S			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	653						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GCAGTTTCTTCCTGTAGTCCA	0.507000													22	41					3.5997e-14	4.82568e-14	0.069288	1	0
PSG11	5680	broad.mit.edu	37	19	43519394	43519394	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:43519394G>A	ENST00000401740.1	-	4	941	c.838C>T	c.(838-840)Cag>Tag	p.Q280*	PSG11_ENST00000403486.1_Nonsense_Mutation_p.Q158*|PSG11_ENST00000320078.7_Nonsense_Mutation_p.Q280*|PSG11_ENST00000306322.7_Nonsense_Mutation_p.Q158*			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	280	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				CCTGATAGCTGAAACTTCCCA	0.463000													37	104					0	0	0.111260	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095660	103095660	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:103095660G>C	ENST00000295269.4	+	2	1076	c.619G>C	c.(619-621)Gac>Cac	p.D207H		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	207					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CTCCGCCGTGGACCCAGTGGC	0.597000													23	43					0	0	0.108266	0	0
PLCH1	23007	broad.mit.edu	37	3	155205894	155205894	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:155205894A>T	ENST00000460012.1	-	21	2809	c.2452T>A	c.(2452-2454)Tac>Aac	p.Y818N	PLCH1_ENST00000340059.7_Missense_Mutation_p.Y836N|PLCH1_ENST00000334686.6_Missense_Mutation_p.Y818N|PLCH1_ENST00000447496.2_Missense_Mutation_p.Y836N|PLCH1_ENST00000494598.1_Missense_Mutation_p.Y836N|PLCH1_ENST00000414191.1_Missense_Mutation_p.Y818N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	836	C2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ACATGCCGGTAGCCTGATAAA	0.368000													14	29					0	0	0.105934	0	0
ZFP14	57677	broad.mit.edu	37	19	36831961	36831961	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:36831961T>C	ENST00000270001.7	-	5	882	c.767A>G	c.(766-768)tAt>tGt	p.Y256C		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					CTTACATTCATAGGGTTTTTC	0.443000													19	53					0	0	0.219247	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156917106	156917106	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:156917106T>C	ENST00000368194.3	-	26	3517	c.2478A>G	c.(2476-2478)atA>atG	p.I826M	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.I786M|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.I202M	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	786	DH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGTGAATCTCTATGAGTTCAG	0.587000													9	52					0	0	0.069234	0	0
CFAP54	144535	broad.mit.edu	37	12	97052045	97052045	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:97052045T>A	ENST00000524981.3	+	5	734	c.734T>A	c.(733-735)cTg>cAg	p.L245Q				Q6ZTY8	CL063_HUMAN		219										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CGCCAGCTTCTGCTGAGAATA	0.403000													31	91					0	0	0.163468	0	0
SLIT1	6585	broad.mit.edu	37	10	98761095	98761095	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:98761095C>A	ENST00000266058.4	-	37	4624	c.4379G>T	c.(4378-4380)cGg>cTg	p.R1460L	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.G1419W	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1460	CTCK.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGGGTCCCCCCGGCACTCGGA	0.662000													10	20					0.0809354	0.0822695	0.080935	1	0
PLD3	23646	broad.mit.edu	37	19	40884006	40884006	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:40884006G>T	ENST00000409587.1	+	13	1796	c.1399G>T	c.(1399-1401)Gac>Tac	p.D467Y	PLD3_ENST00000409281.1_Missense_Mutation_p.D467Y|PLD3_ENST00000409735.4_Missense_Mutation_p.D467Y|PLD3_ENST00000409419.1_Missense_Mutation_p.D467Y|PLD3_ENST00000356508.5_Missense_Mutation_p.D467Y			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	467					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			TTTCCTGAGGGACTGGGACTC	0.657000													10	151					0.000673444	0.000722943	0.069234	1	0
TBL1XR1	79718	broad.mit.edu	37	3	176755885	176755885	+	Splice_Site	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:176755885C>A	ENST00000430069.1	-	12	1382		c.e12+1		TBL1XR1_ENST00000457928.2_Splice_Site			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1						canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			AAGCAAATTACCTTTAAAGTC	0.393000													29	70					4.65686e-17	6.61013e-17	0.193644	1	0
GRXCR1	389207	broad.mit.edu	37	4	42895485	42895485	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:42895485T>A	ENST00000399770.2	+	1	202	c.202T>A	c.(202-204)Tca>Aca	p.S68T		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	68					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						CCACATAGAGTCAGAAGGTGA	0.478000													48	77					0	0	0.139131	0	0
CRX	1406	broad.mit.edu	37	19	48343009	48343009	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:48343009C>G	ENST00000221996.7	+	4	891	c.685C>G	c.(685-687)Cta>Gta	p.L229V	CRX_ENST00000539067.1_Missense_Mutation_p.L229V|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	229					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GGTGCCCCAGCTAGGGGGCCC	0.672000													22	211					0	0	0.069288	0	0
HCN1	348980	broad.mit.edu	37	5	45645509	45645509	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:45645509G>T	ENST00000303230.4	-	2	684	c.627C>A	c.(625-627)gaC>gaA	p.D209E		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	209						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TCACTTTGGGGTCCAGGATGA	0.363000													9	60					3.09899e-07	3.71477e-07	0.047766	1	0
KIT	3815	broad.mit.edu	37	4	55595645	55595645	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:55595645C>T	ENST00000288135.5	+	14	2232	c.2135C>T	c.(2134-2136)tCt>tTt	p.S712F		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	712	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAAGGAGTCTTCCTGGTAA	0.353000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				4	103					0	0	0.184627	0	0
RFPL2	10739	broad.mit.edu	37	22	32590414	32590414	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:32590414T>C	ENST00000400237.1	-	3	1118	c.183A>G	c.(181-183)aaA>aaG	p.K61K	RFPL2_ENST00000400236.3_5'UTR|RFPL2_ENST00000248983.4_Intron			O75678	RFPL2_HUMAN	ret finger protein-like 2	61							zinc ion binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	21						ACGAGGGCCTTTTATTGGTGA	0.532000													17	23					0	0	0.175082	0	0
ZNF208	7757	broad.mit.edu	37	19	22157415	22157415	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:22157415G>T	ENST00000397126.4	-	4	569	c.421C>A	c.(421-423)Cag>Aag	p.Q141K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTTTGCTCTGTGTAGTTGTC	0.323000													19	74					8.00594e-06	9.21846e-06	0.189662	1	0
CALCB	797	broad.mit.edu	37	11	15098940	15098940	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:15098940C>A	ENST00000523376.1	+	9	1628	c.366C>A	c.(364-366)acC>acA	p.T122T	CALCB_ENST00000324229.6_Silent_p.T111T|CALCB_ENST00000533448.1_Silent_p.T111T			P10092	CALCB_HUMAN	calcitonin-related polypeptide beta	111					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity			endometrium(1)|large_intestine(1)|lung(1)|skin(2)	5						TCGTGCCCACCAATGTGGGTT	0.562000													13	38					9.31168e-06	1.06998e-05	0.105934	1	0
LURAP1L	286343	broad.mit.edu	37	9	12775758	12775758	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:12775758A>T	ENST00000319264.3	+	1	739	c.44A>T	c.(43-45)aAg>aTg	p.K15M	LURAP1L_ENST00000489107.1_3'UTR|RP11-3L8.3_ENST00000417638.1_RNA	NM_203403.1	NP_981948.1	Q8IV03	CI150_HUMAN	leucine rich adaptor protein 1-like	15																	ATCGAGCTGAAGCTGGGGCGC	0.602000													8	11					0	0	0.038147	0	0
MUC16	94025	broad.mit.edu	37	19	8987284	8987284	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:8987284G>T	ENST00000397910.4	-	68	42006	c.41803C>A	c.(41803-41805)Ctg>Atg	p.L13935M	MUC16_ENST00000380951.5_Missense_Mutation_p.L576M	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13960				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGTAGCGCAGGTTGTTGATG	0.592000													40	138					2.62258e-09	3.28562e-09	0.117977	1	0
AMER1	139285	broad.mit.edu	37	X	63412181	63412181	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:63412181C>A	ENST00000330258.3	-	2	1258	c.986G>T	c.(985-987)gGt>gTt	p.G329V	AMER1_ENST00000403336.1_Missense_Mutation_p.G329V|AMER1_ENST00000374869.3_Missense_Mutation_p.G329V	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TATTATGTCACCACAACCTGT	0.537000													44	104					1.02591e-13	1.36541e-13	0.117977	1	0
CLDN23	137075	broad.mit.edu	37	8	8560235	8560235	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:8560235C>A	ENST00000519106.1	+	1	788	c.327C>A	c.(325-327)ccC>ccA	p.P109P		NM_194284.2	NP_919260.2	Q96B33	CLD23_HUMAN	claudin 23	109					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)	2		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		AGGACGAGCCCAACTTCGTGC	0.701000													7	6					1.12685e-05	1.28419e-05	0.047766	1	0
MYO5A	4644	broad.mit.edu	37	15	52611497	52611497	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:52611497C>A	ENST00000399231.3	-	38	5162	c.4919G>T	c.(4918-4920)gGg>gTg	p.G1640V	MYO5A_ENST00000399233.2_Missense_Mutation_p.G1637V|MYO5A_ENST00000356338.6_Missense_Mutation_p.G1613V|MYO5A_ENST00000358212.6_Missense_Mutation_p.G1665V|MYO5A_ENST00000553916.1_Missense_Mutation_p.G1638V	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1640	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GGGCTTCACCCCAGACACGCC	0.532000													7	67					1.76689e-08	2.17917e-08	0.058154	1	0
SCARB2	950	broad.mit.edu	37	4	77089567	77089567	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:77089567T>C	ENST00000264896.2	-	9	1525	c.1176A>G	c.(1174-1176)ttA>ttG	p.L392L	SCARB2_ENST00000452464.2_Silent_p.L249L	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	392					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			CAAAGTCATCTAATTTTTTGA	0.408000													23	114					0	0	0.076483	0	0
APLP1	333	broad.mit.edu	37	19	36369001	36369001	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:36369001C>T	ENST00000221891.4	+	13	1762	c.1570C>T	c.(1570-1572)Ctt>Ttt	p.L524F	APLP1_ENST00000589298.2_3'UTR|APLP1_ENST00000586861.1_Missense_Mutation_p.L517F|APLP1_ENST00000537454.2_Missense_Mutation_p.L484F	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	523					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCCATGACCCTTCCAAAAGG	0.532000													12	77					0	0	0.105934	0	0
KIF27	55582	broad.mit.edu	37	9	86498781	86498781	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:86498781T>G	ENST00000297814.2	-	10	2535	c.2392A>C	c.(2392-2394)Aaa>Caa	p.K798Q	KIF27_ENST00000334204.2_Missense_Mutation_p.K798Q|KIF27_ENST00000376347.1_Missense_Mutation_p.K189Q|KIF27_ENST00000413982.1_Missense_Mutation_p.K798Q	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	798					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TTCTGTAATTTTACCTTCATT	0.353000													3	41					0	0	0.150653	0	0
MARS	4141	broad.mit.edu	37	12	57908546	57908546	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:57908546G>A	ENST00000262027.5	+	16	2145	c.2011G>A	c.(2011-2013)Gag>Aag	p.E671K	MARS_ENST00000315473.5_Missense_Mutation_p.E437K	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	671					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTATGTGCCTGAGATGGTGCT	0.512000													35	312					0	0	0.203993	0	0
BEX2	84707	broad.mit.edu	37	X	102564634	102564634	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:102564634C>A	ENST00000536889.1	-	3	724	c.367G>T	c.(367-369)Gag>Tag	p.E123*	BEX2_ENST00000372677.3_Nonsense_Mutation_p.E91*|BEX2_ENST00000372674.1_Nonsense_Mutation_p.E91*	NM_001168399.1|NM_001168400.1	NP_001161871.1|NP_001161872.1	Q9BXY8	BEX2_HUMAN	brain expressed X-linked 2	91					apoptosis|cell cycle|regulation of apoptosis|regulation of cell cycle	cytoplasm|nucleus				endometrium(1)|lung(1)|ovary(1)	3						TGTCTCACCTCCTCCCCAATC	0.512000													57	60					4.96213e-28	7.34396e-28	0.139131	1	0
OSBPL8	114882	broad.mit.edu	37	12	76750467	76750467	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:76750467C>A	ENST00000261183.3	-	23	2955	c.2476G>T	c.(2476-2478)Gaa>Taa	p.E826*	OSBPL8_ENST00000393249.2_Nonsense_Mutation_p.E784*|OSBPL8_ENST00000393250.4_Nonsense_Mutation_p.E784*	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	826					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TCTCCCAGTTCTATTCCTTTC	0.289000													5	31					0.0293803	0.0301406	0.029380	1	0
AGFG2	3268	broad.mit.edu	37	7	100151876	100151876	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:100151876T>C	ENST00000300176.4	+	5	868	c.746T>C	c.(745-747)tTt>tCt	p.F249S	AGFG2_ENST00000262935.4_Intron|AGFG2_ENST00000474713.1_3'UTR	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	249					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TTCCCTGCCTTTGGGGGTAAG	0.532000													15	51					0	0	0.132662	0	0
ADCY8	114	broad.mit.edu	37	8	131792827	131792827	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:131792827G>T	ENST00000286355.5	-	18	5657	c.3565C>A	c.(3565-3567)Cag>Aag	p.Q1189K	ADCY8_ENST00000377928.3_Missense_Mutation_p.Q1058K	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1189					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGGGAGTACTGCCCAGGCAGT	0.498000										HNSCC(32;0.087)			4	143					0.00024832	0.000270761	0.150653	1	0
KDM5B	10765	broad.mit.edu	37	1	202743772	202743772	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:202743772C>T	ENST00000367265.3	-	3	1538	c.374G>A	c.(373-375)aGg>aAg	p.R125K	KDM5B_ENST00000367264.2_Missense_Mutation_p.R125K	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	125	ARID.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CAAGATCTTCCTCTCCACATG	0.363000													3	22					0	0	0.115264	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323715	79323715	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:79323715C>A	ENST00000428286.1	-	8	3598	c.2398G>T	c.(2398-2400)Gaa>Taa	p.E800*	PRUNE2_ENST00000376718.3_Nonsense_Mutation_p.E1159*			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1159					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCGGAACCTTCAGCCATGTAT	0.532000													22	62					4.22769e-11	5.41887e-11	0.116897	1	0
ZNF571	51276	broad.mit.edu	37	19	38055973	38055973	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:38055973C>A	ENST00000328550.2	-	4	1456	c.1357G>T	c.(1357-1359)Gga>Tga	p.G453*	ZNF571-AS1_ENST00000589750.1_RNA|ZNF571-AS1_ENST00000586013.1_RNA|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571_ENST00000451802.2_Nonsense_Mutation_p.G453*|ZNF571-AS1_ENST00000589802.1_RNA|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571_ENST00000358744.3_Nonsense_Mutation_p.G453*|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571_ENST00000593133.1_Nonsense_Mutation_p.G453*|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571_ENST00000590751.1_Intron			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G453*(1)		breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGGCCTTTCCACATTCCTTA	0.378000													15	80					1.99824e-07	2.42674e-07	0.160694	1	0
KCNMA1	3778	broad.mit.edu	37	10	78647067	78647067	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:78647067T>A	ENST00000286627.5	-	27	4446	c.3494A>T	c.(3493-3495)gAg>gTg	p.E1165V	KCNMA1_ENST00000372443.1_Missense_Mutation_p.E1192V|KCNMA1_ENST00000354353.5_Missense_Mutation_p.E1226V|KCNMA1_ENST00000372440.1_Missense_Mutation_p.E1165V|KCNMA1_ENST00000406533.3_Missense_Mutation_p.E1227V|KCNMA1_ENST00000404857.1_Missense_Mutation_p.E1206V|KCNMA1_ENST00000404771.3_Missense_Mutation_p.E1223V|KCNMA1_ENST00000286628.8_Missense_Mutation_p.E1223V	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1223					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GTCCCGGGACTCCCTGGACTT	0.552000													29	321					0	0	0.125774	0	0
HOXC5	3222	broad.mit.edu	37	12	54427126	54427126	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:54427126C>A	ENST00000312492.2	+	1	490	c.220C>A	c.(220-222)Ccc>Acc	p.P74T	HOXC5_ENST00000512206.1_Intron|HOXC4_ENST00000303406.4_Intron	NM_018953.2	NP_061826.1	Q00444	HXC5_HUMAN	homeobox C5	74					regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(2)|urinary_tract(1)	12						CCCCGACCGCCCCGCCTGCAG	0.697000													12	10					9.05144e-12	1.17099e-11	0.105934	1	0
SCN11A	11280	broad.mit.edu	37	3	38913739	38913739	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:38913739C>T	ENST00000302328.3	-	20	3638	c.3440G>A	c.(3439-3441)cGg>cAg	p.R1147Q	SCN11A_ENST00000456224.3_Missense_Mutation_p.R1109Q|SCN11A_ENST00000450244.1_Missense_Mutation_p.R1147Q|SCN11A_ENST00000444237.2_Missense_Mutation_p.R1147Q	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1147					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCGTAGAGTCCGGAAGGACTT	0.473000													23	129					0	0	0.069288	0	0
ZNF425	155054	broad.mit.edu	37	7	148801174	148801174	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:148801174G>C	ENST00000378061.2	-	4	1921	c.1789C>G	c.(1789-1791)Ctc>Gtc	p.L597V		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	597					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGCTCGGTGAGCTGAGACTGA	0.577000													3	67					0	0	0.115264	0	0
ANK2	287	broad.mit.edu	37	4	114179250	114179250	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:114179250C>T	ENST00000357077.4	+	12	1286	c.1233C>T	c.(1231-1233)atC>atT	p.I411I	ANK2_ENST00000394537.3_Silent_p.I411I|ANK2_ENST00000506722.1_Silent_p.I390I|ANK2_ENST00000264366.6_Silent_p.I411I	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	411					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAACCGCATCAAAGTCATGG	0.393000													27	57					0	0	0.144211	0	0
NBPF22P	285622	broad.mit.edu	37	5	85583588	85583588	+	RNA	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:85583588C>G	ENST00000590707.1	+	0	854					NR_003719.2																						CATGATGTGTCTGACTGCCAC	0.552000													7	11					0	0	0.038147	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176767882	176767882	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:176767882C>A	ENST00000430069.1	-	7	864	c.605G>T	c.(604-606)aGc>aTc	p.S202I	TBL1XR1_ENST00000457928.2_Missense_Mutation_p.S202I			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	202					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			GCCACTGGTGCTGTTCTCACT	0.398000													18	169					1.15919e-05	1.31834e-05	0.204396	1	0
KCTD8	386617	broad.mit.edu	37	4	44177124	44177124	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:44177124G>T	ENST00000360029.3	-	2	1388	c.1105C>A	c.(1105-1107)Ccc>Acc	p.P369T		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	369						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TTGTCCTGGGGAGTGCTTGCC	0.483000										HNSCC(17;0.042)			44	122					2.47872e-24	3.64905e-24	0.117977	1	0
TTC7A	57217	broad.mit.edu	37	2	47287970	47287970	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:47287970G>T	ENST00000319190.5	+	19	2583	c.2215G>T	c.(2215-2217)Ggc>Tgc	p.G739C	TTC7A_ENST00000263737.6_Missense_Mutation_p.G385C|TTC7A_ENST00000409245.1_Missense_Mutation_p.G705C|TTC7A_ENST00000394850.2_Missense_Mutation_p.G763C	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	739							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GGAGGCGGCGGGCCTCTTCCC	0.602000													9	42					0.000274275	0.00029673	0.047766	1	0
COL1A2	1278	broad.mit.edu	37	7	94040380	94040380	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:94040380A>T	ENST00000297268.6	+	23	1735	c.1264A>T	c.(1264-1266)Agt>Tgt	p.S422C		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	422					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCTCCTGGTAGTCGTGGTGC	0.517000										HNSCC(75;0.22)			6	9					0	0	0.217242	0	0
ATG2B	55102	broad.mit.edu	37	14	96784090	96784090	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:96784090G>C	ENST00000359933.4	-	19	3875	c.2982C>G	c.(2980-2982)ctC>ctG	p.L994L		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	994										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAGTATTAATGAGCTGACTGG	0.348000													10	82					0	0	0.058154	0	0
C7orf60	154743	broad.mit.edu	37	7	112461933	112461933	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:112461933C>G	ENST00000297145.4	-	5	1249	c.1084G>C	c.(1084-1086)Gat>Cat	p.D362H		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	362										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						tcttctatatctGATCGAACA	0.393000													9	29					0	0	0.047766	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716362	13716362	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:13716362C>T	ENST00000279593.3	-	13	4019	c.3810G>A	c.(3808-3810)gtG>gtA	p.V1270V		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1270					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACGTCACCGCCACTGGGGCAG	0.587000													20	26					0	0	0.234183	0	0
PITX2	5308	broad.mit.edu	37	4	111539531	111539531	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:111539531G>T	ENST00000354925.2	-	7	2409	c.704C>A	c.(703-705)cCg>cAg	p.P235Q	PITX2_ENST00000394598.2_Missense_Mutation_p.P235Q|PITX2_ENST00000355080.5_Missense_Mutation_p.P189Q|PITX2_ENST00000306732.3_Missense_Mutation_p.P242Q|PITX2_ENST00000394595.3_Silent_p.P166P	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	235					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		ACTGGAGCCCGGGACGCCTGT	0.592000													21	63					1.87028e-06	2.18069e-06	0.234183	1	0
AK5	26289	broad.mit.edu	37	1	77763344	77763344	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:77763344C>T	ENST00000344720.5	+	4	1464	c.438C>T	c.(436-438)caC>caT	p.H146H	AK5_ENST00000354567.2_Silent_p.H172H|AK5_ENST00000317704.4_3'UTR	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	172					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						AGAAGATCCACAGTACCAGCA	0.393000													17	77					0	0	0.175082	0	0
ADCY6	112	broad.mit.edu	37	12	49176786	49176786	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:49176786G>C	ENST00000307885.4	-	1	1126	c.432C>G	c.(430-432)ttC>ttG	p.F144L	ADCY6_ENST00000550422.1_Missense_Mutation_p.F144L|ADCY6_ENST00000357869.3_Missense_Mutation_p.F144L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	144					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						TCATCTGGAAGAAGTACCGCT	0.657000													9	39					0	0	0.080935	0	0
CD3EAP	10849	broad.mit.edu	37	19	45912708	45912708	+	Silent	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:45912708T>G	ENST00000309424.3	+	3	1970	c.1482T>G	c.(1480-1482)gcT>gcG	p.A494A	ERCC1_ENST00000300853.3_3'UTR|CD3EAP_ENST00000589804.1_Silent_p.A496A|ERCC1_ENST00000423698.2_3'UTR	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	494					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		GGGAGGAGGCTCCCACAGGCC	0.592000													4	13					0	0	0.150653	0	0
DIRC1	116093	broad.mit.edu	37	2	189599547	189599547	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:189599547C>A	ENST00000308100.4	-	2	371	c.101G>T	c.(100-102)aGc>aTc	p.S34I	AC079613.1_ENST00000431708.1_RNA	NM_052952.2	NP_443184.1	Q969H9	DIRC1_HUMAN	disrupted in renal carcinoma 1	34										large_intestine(1)|lung(6)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)			GTGGGCATTGCTGAGTGGTGG	0.498000													16	97					1.67942e-08	2.07589e-08	0.175082	1	0
SLFN5	162394	broad.mit.edu	37	17	33586427	33586427	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:33586427G>C	ENST00000299977.4	+	2	866	c.718G>C	c.(718-720)Gga>Cga	p.G240R	SLFN5_ENST00000592325.1_Missense_Mutation_p.G240R|SLFN5_ENST00000542451.1_Missense_Mutation_p.G240R	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	240					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TCAAGTGATTGGATGTGAAAA	0.408000													29	107					0	0	0.144211	0	0
PEX6	5190	broad.mit.edu	37	6	42934365	42934365	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:42934365C>T	ENST00000304611.8	-	10	2061	c.1992G>A	c.(1990-1992)gaG>gaA	p.E664E	PEX6_ENST00000244546.4_Silent_p.E664E	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	664					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			ACAGCTCCCCCTCATCCTCCT	0.612000													29	80					0	0	0.134883	0	0
ZNF233	353355	broad.mit.edu	37	19	44778388	44778388	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:44778388C>T	ENST00000391958.2	+	5	1702	c.1575C>T	c.(1573-1575)gcC>gcT	p.A525A	ZNF233_ENST00000334152.1_Silent_p.A507A|ZNF233_ENST00000592581.1_3'UTR|ZNF235_ENST00000589799.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				ATCTTCAGGCCCATCAGAGAG	0.478000													12	89					0	0	0.093190	0	0
CNST	163882	broad.mit.edu	37	1	246784904	246784904	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:246784904G>T	ENST00000366513.4	+	3	822	c.553G>T	c.(553-555)Gat>Tat	p.D185Y	CNST_ENST00000366512.3_Missense_Mutation_p.D185Y|CNST_ENST00000483271.1_3'UTR	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	185					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						TGAGCAGTTGGATTCAAGAGC	0.453000													74	163					6.20995e-33	9.34017e-33	0.139131	1	0
NWD1	284434	broad.mit.edu	37	19	16860107	16860107	+	Silent	SNP	T	T	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:16860107T>G	ENST00000524140.2	+	6	1072	c.654T>G	c.(652-654)gcT>gcG	p.A218A	NWD1_ENST00000379808.3_Silent_p.A218A|NWD1_ENST00000552788.1_Silent_p.A218A|NWD1_ENST00000339803.6_Silent_p.A83A|NWD1_ENST00000549814.1_Silent_p.A218A|NWD1_ENST00000523826.1_Silent_p.A12A	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	218			A -> T (in dbSNP:rs706764).				ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCCTGGACGCTGATGCCCAGA	0.592000													9	36					0	0	0.047766	0	0
SOGA3	387104	broad.mit.edu	37	6	127797313	127797313	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:127797313C>A	ENST00000556132.1	-	6	2722	c.1858G>T	c.(1858-1860)Gac>Tac	p.D620Y	SOGA3_ENST00000465909.2_Missense_Mutation_p.D620Y|SOGA3_ENST00000368268.2_Missense_Mutation_p.D620Y|SOGA3_ENST00000525778.1_Missense_Mutation_p.D620Y|SOGA3_ENST00000481848.2_Missense_Mutation_p.D620Y	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	620						integral to membrane											CTAAGGTCGTCCAGTTCCGCC	0.607000													30	48					2.20474e-14	2.98446e-14	0.193644	1	0
MANEA	79694	broad.mit.edu	37	6	96053765	96053765	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:96053765C>A	ENST00000358812.4	+	5	1007	c.873C>A	c.(871-873)cgC>cgA	p.R291R	MANEA_ENST00000474553.1_3'UTR	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	291	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		GGAGTATTCGCAATTCTCCTT	0.373000													15	87					1.5739e-10	2.00347e-10	0.146539	1	0
BRCC3	79184	broad.mit.edu	37	X	154348415	154348415	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:154348415C>G	ENST00000369462.1	+	11	966	c.941C>G	c.(940-942)tCt>tGt	p.S314C	BRCC3_ENST00000340647.4_Missense_Mutation_p.S290C|BRCC3_ENST00000330045.7_Missense_Mutation_p.S289C|MTCP1_ENST00000362018.2_Intron|BRCC3_ENST00000369459.2_Missense_Mutation_p.S245C|BRCC3_ENST00000399042.1_Missense_Mutation_p.S315C	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	314					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAACTTTCTTCTCTAGAATAA	0.413000													43	126					0	0	0.139131	0	0
ATR	545	broad.mit.edu	37	3	142281172	142281172	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:142281172G>A	ENST00000350721.4	-	4	1193	c.1072C>T	c.(1072-1074)Cca>Tca	p.P358S	ATR_ENST00000383101.3_Missense_Mutation_p.P358S	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	358					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity	p.P358S(1)		NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TACCCAGCTGGCACAAATTTA	0.413000								Other conserved DNA damage response genes					3	41					0	0	0.115264	0	0
IAPP	3375	broad.mit.edu	37	12	21531177	21531177	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:21531177G>C	ENST00000542023.1	+	4	280	c.179G>C	c.(178-180)aGg>aCg	p.R60T	IAPP_ENST00000539393.1_Missense_Mutation_p.Q29H|SLCO1A2_ENST00000473830.1_Intron|SLCO1A2_ENST00000307378.6_Intron|IAPP_ENST00000240652.3_Missense_Mutation_p.Q29H|SLCO1A2_ENST00000537524.1_Intron			P10997	IAPP_HUMAN	islet amyloid polypeptide	0					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity			lung(3)	3					Perindopril(DB00790)	CCAGTCATCAGGTGGAAAAGC	0.413000													14	53					0	0	0.132662	0	0
EPHA6	285220	broad.mit.edu	37	3	97185324	97185324	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:97185324C>A	ENST00000514100.1	+	4	310	c.68C>A	c.(67-69)tCa>tAa	p.S23*	EPHA6_ENST00000389672.5_Intron|EPHA6_ENST00000442602.2_Intron|EPHA6_ENST00000502694.1_Nonsense_Mutation_p.S23*	NM_001278300.1	NP_001265229.1	Q9UF33	EPHA6_HUMAN	EPH receptor A6	534						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						tttattgcctcaggtaactga	0.413000													17	78					1.99824e-07	2.42674e-07	0.160694	1	0
HTR1A	3350	broad.mit.edu	37	5	63256808	63256808	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:63256808C>A	ENST00000323865.3	-	1	972	c.739G>T	c.(739-741)Gcc>Tcc	p.A247S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	247					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGCTGCGGGGCGGGAGATGCT	0.637000													11	98					3.5997e-14	4.82568e-14	0.069288	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995953	140995953	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:140995953C>A	ENST00000285879.4	+	4	3049	c.2763C>A	c.(2761-2763)ctC>ctA	p.L921L	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	921	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTTCTCCTCAAATATCAAG	0.493000										HNSCC(15;0.026)			4	171					0.014758	0.0152243	0.184627	1	0
CACNA1B	774	broad.mit.edu	37	9	140852090	140852090	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:140852090G>A	ENST00000371372.1	+	10	1429	c.1284G>A	c.(1282-1284)ctG>ctA	p.L428L	CACNA1B_ENST00000277551.2_Silent_p.L428L|CACNA1B_ENST00000371357.1_Silent_p.L429L|CACNA1B_ENST00000371355.4_Silent_p.L429L|CACNA1B_ENST00000371363.1_Silent_p.L428L|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	428					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GAAATGACCTGATCCACGCAG	0.577000													13	11					0	0	0.105934	0	0
WDR64	128025	broad.mit.edu	37	1	241904891	241904891	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:241904891A>C	ENST00000366552.2	+	11	1572	c.1365A>C	c.(1363-1365)gaA>gaC	p.E455D	WDR64_ENST00000437684.2_Missense_Mutation_p.E455D	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	455										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			ACACTCATGAACGAGAAATCA	0.353000													10	41					0	0	0.058154	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576362	33576362	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:33576362G>A	ENST00000504830.1	-	19	4104	c.3769C>T	c.(3769-3771)Cca>Tca	p.P1257S	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P1172S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1257	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GAGGGTTCTGGCTGGTGGTCT	0.522000										HNSCC(64;0.19)			28	141					0	0	0.125774	0	0
ATP2B4	493	broad.mit.edu	37	1	203696674	203696674	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:203696674G>C	ENST00000357681.5	+	20	4407	c.3284G>C	c.(3283-3285)cGg>cCg	p.R1095P	ATP2B4_ENST00000466407.1_3'UTR|ATP2B4_ENST00000367219.3_Missense_Mutation_p.R1083P|ATP2B4_ENST00000367218.3_Missense_Mutation_p.R1095P|ATP2B4_ENST00000391954.2_Missense_Mutation_p.R1059P|ATP2B4_ENST00000341360.2_Missense_Mutation_p.R1095P	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1095	Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.R1095Q(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CTCTGGTTCCGGGGCCTGAAC	0.567000													8	82					0	0	0.058154	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6876	6876	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrM:6876G>A	ENST00000361624.2	+	1	973	c.973G>A	c.(973-975)Gcc>Acc	p.325_325insT						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TTAGCTGACTCGCCACACTCC	0.463000													177	73					0	0	0.139131	0	0
SVEP1	79987	broad.mit.edu	37	9	113231319	113231319	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:113231319C>A	ENST00000401783.2	-	17	3397	c.3061G>T	c.(3061-3063)Gga>Tga	p.G1021*	SVEP1_ENST00000302728.8_Nonsense_Mutation_p.G1021*|SVEP1_ENST00000374469.1_Nonsense_Mutation_p.G998*|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1021					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGATAGGATCCGATCCGGCAG	0.418000													14	72					2.31682e-05	2.59765e-05	0.132662	1	0
PCDHA6	56142	broad.mit.edu	37	5	140208840	140208840	+	Silent	SNP	G	G	T	rs365581		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:140208840G>T	ENST00000529310.1	+	1	1278	c.1164G>T	c.(1162-1164)tcG>tcT	p.S388S	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.S388S|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACTGCTCGCTGACGCCTC	0.552000													40	81					7.53189e-24	1.10296e-23	0.098360	1	0
RELN	5649	broad.mit.edu	37	7	103124140	103124140	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:103124140C>A	ENST00000428762.1	-	62	10300	c.10141G>T	c.(10141-10143)Gac>Tac	p.D3381Y	RELN_ENST00000424685.2_Missense_Mutation_p.D3381Y|RELN_ENST00000473945.1_5'UTR|RELN_ENST00000343529.5_Missense_Mutation_p.D3381Y|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3381					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTGTGAAGTCCTTTGGCTGG	0.547000													18	136					1.2644e-06	1.49307e-06	0.219247	1	0
TAF5L	27097	broad.mit.edu	37	1	229738212	229738212	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:229738212C>T	ENST00000366675.3	-	4	790	c.702G>A	c.(700-702)caG>caA	p.Q234Q	TAF5L_ENST00000366676.1_Silent_p.Q234Q|TAF5L_ENST00000258281.2_Silent_p.Q234Q	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	234					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				CAGCCTCGTTCTGCAGAATAG	0.552000													3	78					0	0	0.150653	0	0
DGKI	9162	broad.mit.edu	37	7	137150706	137150706	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:137150706G>T	ENST00000453654.1	-	27	2253	c.1714C>A	c.(1714-1716)Ccg>Acg	p.P572T	DGKI_ENST00000424189.2_Missense_Mutation_p.P875T|DGKI_ENST00000446122.1_Missense_Mutation_p.P844T|DGKI_ENST00000288490.5_Missense_Mutation_p.P862T			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	862					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GTCCCCGCCGGCTGTGACACC	0.532000													22	70					1.96895e-08	2.42298e-08	0.076483	1	0
CIR1	9541	broad.mit.edu	37	2	175252428	175252428	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:175252428T>C	ENST00000342016.3	-	2	244	c.152A>G	c.(151-153)gAa>gGa	p.E51G	CIR1_ENST00000362053.5_Missense_Mutation_p.E51G	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	51	Interaction with RBPJ.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						ATCATATGATTCTTGTTCTTT	0.279000													16	20					0	0	0.146539	0	0
GCG	2641	broad.mit.edu	37	2	163000564	163000564	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:163000564C>A	ENST00000418842.2	-	5	763	c.509G>T	c.(508-510)tGg>tTg	p.W170L	GCG_ENST00000375497.3_Missense_Mutation_p.W170L	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	170					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	CTGAATCAACCAGTTTATAAA	0.408000													10	49					2.17888e-05	2.45289e-05	0.058154	1	0
EFCAB6	64800	broad.mit.edu	37	22	43933348	43933348	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:43933348C>A	ENST00000262726.7	-	29	4210	c.3957G>T	c.(3955-3957)aaG>aaT	p.K1319N	EFCAB6_ENST00000396231.2_Missense_Mutation_p.K1167N|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1319	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CCTGGATTCTCTTCCGGAGCC	0.577000													22	135					2.39556e-15	3.2991e-15	0.076483	1	0
WDR44	54521	broad.mit.edu	37	X	117540866	117540866	+	Silent	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:117540866A>C	ENST00000254029.3	+	10	1805	c.1410A>C	c.(1408-1410)tcA>tcC	p.S470S	WDR44_ENST00000371825.3_Silent_p.S470S|WDR44_ENST00000371822.5_Silent_p.S445S	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	470						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						ATGATCCTTCATCAAGTGATG	0.353000													18	55					0	0	0.175082	0	0
OR4C11	219429	broad.mit.edu	37	11	55371655	55371655	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:55371655G>A	ENST00000302231.4	-	1	219	c.195C>T	c.(193-195)tcC>tcT	p.S65S		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						AATCTGCAAAGGACAAATAAA	0.408000													28	58					0	0	0.125774	0	0
REG1A	5967	broad.mit.edu	37	2	79350329	79350329	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:79350329G>T	ENST00000233735.1	+	6	592	c.489G>T	c.(487-489)aaG>aaT	p.K163N		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	163	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TTGTCTGCAAGTTCAAAAACT	0.413000													8	36					0.000157383	0.000172966	0.038147	1	0
PLSCR4	57088	broad.mit.edu	37	3	145917613	145917613	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:145917613G>C	ENST00000354952.2	-	6	851	c.611C>G	c.(610-612)tCt>tGt	p.S204C	PLSCR4_ENST00000493382.1_Missense_Mutation_p.S204C|PLSCR4_ENST00000383083.2_Intron|PLSCR4_ENST00000433593.2_Intron|PLSCR4_ENST00000446574.2_Missense_Mutation_p.S204C	NM_020353.2	NP_065086.2	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4	204					blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			kidney(1)|large_intestine(6)|lung(9)|urinary_tract(1)	17						TTGTCTGGCAGAGGGGCAACA	0.507000													15	22					0	0	0.175082	0	0
AIM1	202	broad.mit.edu	37	6	106967275	106967275	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:106967275A>T	ENST00000369066.3	+	2	1455	c.968A>T	c.(967-969)aAg>aTg	p.K323M		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	323							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAACCTGAAAAGAAAGTAATG	0.443000													16	28					0	0	0.175082	0	0
DGKI	9162	broad.mit.edu	37	7	137330263	137330263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:137330263C>T	ENST00000424189.2	-	6	988	c.759G>A	c.(757-759)tgG>tgA	p.W253*	DGKI_ENST00000446122.1_Nonsense_Mutation_p.W253*|DGKI_ENST00000453654.1_5'UTR|DGKI_ENST00000288490.5_Nonsense_Mutation_p.W253*			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	253					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GCCTGTGCACCCAGTGATGAC	0.483000													10	43					0	0	0.080935	0	0
SMIM12	113444	broad.mit.edu	37	1	35321354	35321354	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:35321354C>G	ENST00000521580.2	-	2	369	c.225G>C	c.(223-225)aaG>aaC	p.K75N	SMIM12_ENST00000456842.1_Missense_Mutation_p.K75N|SMIM12_ENST00000423898.1_Missense_Mutation_p.K75N|SMIM12_ENST00000446026.1_Missense_Mutation_p.K75N|SMIM12_ENST00000417239.1_Missense_Mutation_p.K75N	NM_001164824.1|NM_001164825.1|NM_138428.5	NP_001158296.1|NP_001158297.1|NP_612437.3			small integral membrane protein 12																		CAAATTCTAGCTTGTCCTTAA	0.552000													4	19					0	0	0.150653	0	0
BAZ1B	9031	broad.mit.edu	37	7	72861596	72861596	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:72861596C>A	ENST00000339594.4	-	16	4180	c.3842G>T	c.(3841-3843)cGa>cTa	p.R1281L	BAZ1B_ENST00000404251.1_Missense_Mutation_p.R1281L	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1281					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				ATACTTACATCGCAAACCAGC	0.488000													48	161					2.01872e-29	3.01179e-29	0.139131	1	0
LTBP1	4052	broad.mit.edu	37	2	33482463	33482463	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:33482463G>T	ENST00000404816.2	+	12	2633	c.2280G>T	c.(2278-2280)aaG>aaT	p.K760N	LTBP1_ENST00000402934.1_Intron|LTBP1_ENST00000404525.1_Intron|LTBP1_ENST00000390003.4_Missense_Mutation_p.K434N|LTBP1_ENST00000418533.2_Missense_Mutation_p.K434N|LTBP1_ENST00000354476.3_Missense_Mutation_p.K760N|LTBP1_ENST00000407925.1_Missense_Mutation_p.K434N			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	760					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCAAGCCAAAGAACACTCAAC	0.522000													6	45					0.00198382	0.00209718	0.029380	1	0
OR8B8	26493	broad.mit.edu	37	11	124310147	124310147	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:124310147T>A	ENST00000328064.2	-	1	907	c.835A>T	c.(835-837)Acc>Tcc	p.T279S		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ACCACAGTGGTATAGAATAGG	0.413000													28	58					0	0	0.134883	0	0
COL9A1	1297	broad.mit.edu	37	6	70935644	70935644	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:70935644C>T	ENST00000357250.6	-	37	2730	c.2572G>A	c.(2572-2574)Ggt>Agt	p.G858S	COL9A1_ENST00000320755.7_Missense_Mutation_p.G615S|RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Missense_Mutation_p.G615S	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	858	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCTGGGAGACCTATAGCTCCA	0.423000													6	90					0	0	0.217242	0	0
HEXIM1	10614	broad.mit.edu	37	17	43227346	43227346	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:43227346G>A	ENST00000332499.2	+	1	2663	c.789G>A	c.(787-789)ctG>ctA	p.L263L		NM_006460.2	NP_006451.1	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	263					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			breast(1)|kidney(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCGAGTTTCTGCAGCGGGACT	0.597000													6	31					0	0	0.217242	0	0
MUC16	94025	broad.mit.edu	37	19	9067655	9067655	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:9067655C>T	ENST00000397910.4	-	3	19994	c.19791G>A	c.(19789-19791)gtG>gtA	p.V6597V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6599	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.V6597V(2)|p.V2230V(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTGGTCCCCACATTGGTTA	0.438000													119	329					0	0	0.139131	0	0
FAM19A1	407738	broad.mit.edu	37	3	68587942	68587942	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:68587942G>T	ENST00000478136.1	+	4	785	c.295G>T	c.(295-297)Gag>Tag	p.E99*	FAM19A1_ENST00000496687.1_Nonsense_Mutation_p.E99*	NM_213609.3	NP_998774.2	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A1	99						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)	7		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		GTGTGAGATGGAGCCTTGCCT	0.458000													9	34					7.48243e-07	8.89239e-07	0.058154	1	0
C6	729	broad.mit.edu	37	5	41176655	41176655	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:41176655G>T	ENST00000263413.3	-	8	1354	c.1090C>A	c.(1090-1092)Cat>Aat	p.H364N	C6_ENST00000337836.5_Missense_Mutation_p.H364N|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	364	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GTGAAGTAATGAGTCCCAAAG	0.438000													25	57					1.74197e-06	2.03536e-06	0.116897	1	0
SMG1	23049	broad.mit.edu	37	16	18887705	18887705	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:18887705A>G	ENST00000446231.2	-	13	2043	c.1631T>C	c.(1630-1632)gTa>gCa	p.V544A	SMG1_ENST00000389467.3_Missense_Mutation_p.V544A|SMG1_ENST00000565224.1_Missense_Mutation_p.V518A			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	544	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AGCATGGGCTACAGCAACAAC	0.338000													14	25					0	0	0.119110	0	0
WBP2NL	164684	broad.mit.edu	37	22	42416011	42416011	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:42416011G>T	ENST00000328823.9	+	4	348	c.317G>T	c.(316-318)gGc>gTc	p.G106V	WBP2NL_ENST00000543212.1_Missense_Mutation_p.G32V	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	106					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						CCCCCAGGTGGCTGGGAAGGA	0.468000													31	118					1.45844e-13	1.93644e-13	0.173368	1	0
ZNF354B	117608	broad.mit.edu	37	5	178310767	178310767	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:178310767T>A	ENST00000322434.3	+	5	1540	c.1314T>A	c.(1312-1314)taT>taA	p.Y438*		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAAATTGTATAATTGTAATG	0.358000													19	36					0	0	0.189662	0	0
TP53	7157	broad.mit.edu	37	17	7578257	7578257	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:7578257C>A	ENST00000420246.2	-	6	724	c.592G>T	c.(592-594)Gaa>Taa	p.E198*	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.E198*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E198*|TP53_ENST00000413465.2_Nonsense_Mutation_p.E198*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E198*|TP53_ENST00000455263.2_Nonsense_Mutation_p.E198*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	198	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		E -> D (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E198*(27)|p.0?(8)|p.E198K(5)|p.?(5)|p.P191_E198>Q(3)|p.E105*(3)|p.E66*(3)|p.E198fs*11(2)|p.E198Q(2)|p.E198fs*7(1)|p.E198fs*49(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAATTTCCTTCCACTCGGATA	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	54					3.1745e-13	4.18491e-13	0.134883	1	0
INHBA	3624	broad.mit.edu	37	7	41729647	41729647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:41729647C>A	ENST00000242208.4	-	3	1128	c.882G>T	c.(880-882)atG>atT	p.M294I	INHBA_ENST00000442711.1_Missense_Mutation_p.M294I|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	294					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GGGCCTGCAGCATGAGGAAAG	0.567000										TSP Lung(11;0.080)			25	74					9.04412e-07	1.07025e-06	0.099896	1	0
VAV3	10451	broad.mit.edu	37	1	108152588	108152588	+	Splice_Site	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:108152588C>T	ENST00000370056.4	-	22	2255		c.e22-1		VAV3_ENST00000343258.4_Splice_Site|VAV3_ENST00000544443.1_Splice_Site|VAV3_ENST00000527011.1_Splice_Site|VAV3_ENST00000415432.2_Splice_Site	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GTTTGGGCACCTAGGATATAA	0.353000													13	56					0	0	0.132662	0	0
USP29	57663	broad.mit.edu	37	19	57640187	57640187	+	Silent	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:57640187A>T	ENST00000254181.4	+	4	598	c.144A>T	c.(142-144)atA>atT	p.I48I	USP29_ENST00000598197.1_Silent_p.I48I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	48					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAAATTTATAAGAATTTTTC	0.353000													3	18					0	0	0.115264	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457546	66457546	+	RNA	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:66457546T>C	ENST00000424345.1	+	0	67																											TTCTGTCTCCTTGATGCGGTG	0.562000													3	28					0	0	0.184627	0	0
MUC16	94025	broad.mit.edu	37	19	9083779	9083779	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:9083779C>T	ENST00000397910.4	-	1	8239	c.8036G>A	c.(8035-8037)gGc>gAc	p.G2679D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2679	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGACTGTGCCAAGACTATC	0.498000													27	112					0	0	0.091800	0	0
ADAM28	10863	broad.mit.edu	37	8	24187507	24187507	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:24187507G>T	ENST00000265769.4	+	11	1092	c.982G>T	c.(982-984)Gat>Tat	p.D328Y	ADAM28_ENST00000437154.2_Missense_Mutation_p.D328Y|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000518516.1_3'UTR|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000540823.1_Missense_Mutation_p.D95Y|ADAM28_ENST00000397649.3_Missense_Mutation_p.D75Y|RP11-624C23.1_ENST00000523700.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	328	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GGACCACAGCGATAATCTTCT	0.393000													49	89					2.3318e-11	2.99572e-11	0.139131	1	0
MFSD8	256471	broad.mit.edu	37	4	128861088	128861088	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:128861088C>A	ENST00000296468.3	-	7	745	c.618G>T	c.(616-618)caG>caT	p.Q206H	MFSD8_ENST00000513559.1_Missense_Mutation_p.Q161H|MFSD8_ENST00000541133.1_Intron|MFSD8_ENST00000515130.1_5'UTR	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	206					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						ACATGTTTATCTGCAGTTTAA	0.303000													8	22					0.00448238	0.00469381	0.047766	1	0
GIGYF2	26058	broad.mit.edu	37	2	233684583	233684583	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:233684583G>C	ENST00000373566.3	+	22	2680	c.2483G>C	c.(2482-2484)cGa>cCa	p.R828P	GIGYF2_ENST00000373563.4_Missense_Mutation_p.R806P|GIGYF2_ENST00000409480.1_Missense_Mutation_p.R828P|GIGYF2_ENST00000409547.1_Missense_Mutation_p.R806P|GIGYF2_ENST00000409451.3_Missense_Mutation_p.R827P|GIGYF2_ENST00000409196.3_Missense_Mutation_p.R800P|GIGYF2_ENST00000452341.2_Missense_Mutation_p.R637P			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	806	Gln-rich.|Glu-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCATTAAGGCGACAGCGAGAA	0.512000													3	23					0	0	0.115264	0	0
GPR149	344758	broad.mit.edu	37	3	154147167	154147167	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:154147167T>A	ENST00000389740.2	-	1	337	c.238A>T	c.(238-240)Atg>Ttg	p.M80L		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	80						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGGACGCTCATGAGATCATCC	0.478000													15	143					0	0	0.132662	0	0
TTN	7273	broad.mit.edu	37	2	179393311	179393311	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:179393311A>T	ENST00000589042.1	-	360	107391	c.107167T>A	c.(107167-107169)Tgt>Agt	p.C35723S	TTN_ENST00000342992.6_Missense_Mutation_p.C33155S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.C26783S|TTN_ENST00000342175.6_Missense_Mutation_p.C26850S|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.C26658S|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.C34082S|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34082							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGATTTCACAAGTAAAGAGA	0.353000													6	33					0	0	0.029380	0	0
FAM178A	55719	broad.mit.edu	37	10	102684599	102684599	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:102684599G>T	ENST00000238961.3	+	5	1989	c.1841G>T	c.(1840-1842)aGt>aTt	p.S614I	FAM178A_ENST00000370269.3_Missense_Mutation_p.S614I|FAM178A_ENST00000370271.3_Missense_Mutation_p.S614I	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	614																	AACCTAGACAGTGATGAGGAA	0.413000													8	67					0.00307968	0.00323716	0.038147	1	0
ROS1	6098	broad.mit.edu	37	6	117647397	117647397	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:117647397T>C	ENST00000368508.3	-	33	5745	c.5547A>G	c.(5545-5547)atA>atG	p.I1849M	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.I1843M	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1849	Fibronectin type-III 9.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTCCAACTAATATAATATTCT	0.328000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								32	26					0	0	0.183431	0	0
ZNF99	7652	broad.mit.edu	37	19	22939299	22939299	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:22939299G>A	ENST00000397104.3	-	7	2871	c.2872C>T	c.(2872-2874)Cgc>Tgc	p.R958C						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTAGTAAGGCGTGAGAAATGG	0.353000													14	45					0	0	0.119110	0	0
LOC645166	645166	broad.mit.edu	37	1	148951273	148951273	+	RNA	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:148951273C>T	ENST00000539543.1	+	0	283					NR_027355.1																						tgggtactggctgagttctgg	0.483000													3	29					0	0	0.150653	0	0
TAF9	6880	broad.mit.edu	37	5	68661018	68661018	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:68661018T>A	ENST00000328663.4	-	3	1013	c.547A>T	c.(547-549)Aca>Tca	p.T183S	TAF9_ENST00000380822.4_Intron|TAF9_ENST00000506736.1_Missense_Mutation_p.T183S|TAF9_ENST00000502819.1_Intron|TAF9_ENST00000380818.3_Intron|TAF9_ENST00000217893.5_Missense_Mutation_p.T183S|TAF9_ENST00000512561.1_Intron	NM_001015892.1	NP_001015892.1	Q9Y3D8	KAD6_HUMAN	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	0						Cajal body	adenylate kinase activity|ATP binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	8		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		CTTTGACCTGTGAGGGACATG	0.463000													25	75					0	0	0.091800	0	0
OR9I1	219954	broad.mit.edu	37	11	57886056	57886056	+	Silent	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:57886056A>T	ENST00000302610.1	-	1	860	c.861T>A	c.(859-861)ccT>ccA	p.P287P	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				TGTAGATCAGAGGGTTCAGCA	0.458000													38	90					0	0	0.235728	0	0
LPCAT1	79888	broad.mit.edu	37	5	1501647	1501647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:1501647C>A	ENST00000283415.3	-	2	339	c.207G>T	c.(205-207)tgG>tgT	p.W69C		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	69					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GTGCGAGGGGCCAGGCCAGCA	0.657000													9	24					3.09899e-07	3.71477e-07	0.047766	1	0
OR2B6	26212	broad.mit.edu	37	6	27925319	27925319	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:27925319C>A	ENST00000244623.1	+	1	301	c.301C>A	c.(301-303)Ctt>Att	p.L101I		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGTAGCCCAGCTTTTCATATT	0.443000													15	42					2.32078e-09	2.91411e-09	0.132662	1	0
RBM46	166863	broad.mit.edu	37	4	155717947	155717947	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:155717947G>C	ENST00000510397.1	+	2	222	c.43G>C	c.(43-45)Gtt>Ctt	p.V15L	RBM46_ENST00000514866.1_Missense_Mutation_p.V15L|RBM46_ENST00000281722.3_Missense_Mutation_p.V15L	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	15							nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				ATGCAGTAAAGTTCGAACTGG	0.358000													13	32					0	0	0.105934	0	0
OR2G6	391211	broad.mit.edu	37	1	248685554	248685554	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:248685554A>T	ENST00000343414.4	+	1	639	c.607A>T	c.(607-609)Agt>Tgt	p.S203C		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTGTGGCCAGTGTAGTCTT	0.468000													14	107					0	0	0.105934	0	0
DYSF	8291	broad.mit.edu	37	2	71788996	71788996	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:71788996G>A	ENST00000258104.3	+	23	2554	c.2277G>A	c.(2275-2277)aaG>aaA	p.K759K	DYSF_ENST00000409744.1_Silent_p.K746K|DYSF_ENST00000410041.1_Silent_p.K777K|DYSF_ENST00000409762.1_Silent_p.K776K|DYSF_ENST00000409582.3_Silent_p.K776K|DYSF_ENST00000409366.1_Silent_p.K760K|DYSF_ENST00000394120.2_Silent_p.K760K|DYSF_ENST00000409651.1_Silent_p.K791K|DYSF_ENST00000413539.2_Silent_p.K790K|DYSF_ENST00000429174.2_Silent_p.K759K|DYSF_ENST00000410020.3_Silent_p.K777K	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	759						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGGCCCTGAAGCTCGGCCACA	0.632000													4	40					0	0	0.150653	0	0
SNX14	57231	broad.mit.edu	37	6	86259576	86259576	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:86259576T>A	ENST00000314673.3	-	8	832	c.656A>T	c.(655-657)cAg>cTg	p.Q219L	SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000369627.2_Missense_Mutation_p.Q219L|SNX14_ENST00000346348.3_Missense_Mutation_p.Q175L|SNX14_ENST00000505648.1_Missense_Mutation_p.Q167L|SNX14_ENST00000513865.1_Missense_Mutation_p.Q219L	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	219	PXA.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AGCAGCTTGCTGTAAAAACTC	0.308000													15	58					0	0	0.132662	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993845	140993845	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:140993845G>A	ENST00000285879.4	+	4	941	c.655G>A	c.(655-657)Gag>Aag	p.E219K	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	219							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTTCCCCTGAGAGAACTCA	0.488000										HNSCC(15;0.026)			16	103					0	0	0.246493	0	0
DNER	92737	broad.mit.edu	37	2	230253033	230253033	+	Silent	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:230253033A>G	ENST00000341772.4	-	11	1937	c.1803T>C	c.(1801-1803)aaT>aaC	p.N601N		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	601	EGF-like 10; calcium-binding (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGTTATAACCATTGGGCTGGT	0.478000													20	132					0	0	0.234183	0	0
ST3GAL6	10402	broad.mit.edu	37	3	98487365	98487365	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:98487365T>A	ENST00000394162.1	+	3	548	c.81T>A	c.(79-81)aaT>aaA	p.N27K	ST3GAL6_ENST00000462152.1_Intron|ST3GAL6_ENST00000265261.6_5'UTR|ST3GAL6_ENST00000483910.1_Missense_Mutation_p.N27K|ST3GAL6_ENST00000468553.1_Missense_Mutation_p.N27K	NM_006100.2	NP_006091.1	Q9Y274	SIA10_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	27					amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(1)	19						GGGGAACGAATGTCTATTGGT	0.373000													34	107					0	0	0.214465	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857016	19857016	+	RNA	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:19857016T>A	ENST00000548109.1	+	0	72																											CGTATTATACTCTCAGCATCC	0.383000													10	83					0	0	0.132662	0	0
NPEPPS	9520	broad.mit.edu	37	17	45662869	45662869	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:45662869G>T	ENST00000322157.4	+	6	889	c.652G>T	c.(652-654)Gta>Tta	p.V218L	NPEPPS_ENST00000530173.1_Missense_Mutation_p.V214L|NPEPPS_ENST00000544660.1_Missense_Mutation_p.V138L|NPEPPS_ENST00000525037.1_3'UTR	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	218					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						CTTAAAGAATGTAATTGACCG	0.343000													39	41					1.07121e-22	1.56453e-22	0.246493	1	0
PTGFR	5737	broad.mit.edu	37	1	79002132	79002132	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:79002132G>T	ENST00000370757.3	+	3	1077	c.840G>T	c.(838-840)ctG>ctT	p.L280L	PTGFR_ENST00000370756.3_3'UTR|PTGFR_ENST00000370758.1_Silent_p.L280L	NM_000959.3	NP_000950.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	280					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ATCATTCTCTGGAAACCTGTG	0.363000													9	40					1.12685e-05	1.28419e-05	0.047766	1	0
CASP2	835	broad.mit.edu	37	7	142991376	142991376	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:142991376A>G	ENST00000310447.5	+	5	770	c.529A>G	c.(529-531)Aag>Gag	p.K177E	CASP2_ENST00000493642.1_3'UTR	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	177					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					CCTTCAGGTGAAGCCTTGCAC	0.413000													33	101					0	0	0.235728	0	0
RYR3	6263	broad.mit.edu	37	15	34040333	34040333	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:34040333T>C	ENST00000389232.4	+	54	8078	c.8008T>C	c.(8008-8010)Tgg>Cgg	p.W2670R	RYR3_ENST00000415757.3_Missense_Mutation_p.W2670R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2670	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AATTTATCGCTGGCCTGCGCG	0.527000													13	76					0	0	0.132662	0	0
CNGA3	1261	broad.mit.edu	37	2	99012586	99012586	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:99012586C>A	ENST00000393504.1	+	8	1370	c.953C>A	c.(952-954)gCc>gAc	p.A318D	CNGA3_ENST00000272602.2_Missense_Mutation_p.A318D|CNGA3_ENST00000436404.2_Missense_Mutation_p.A300D|CNGA3_ENST00000409937.1_Missense_Mutation_p.A322D	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	318					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						CACTGGAATGCCTGCATCTAC	0.473000													7	66					3.09899e-07	3.71477e-07	0.047766	1	0
LINC01410	103352539	broad.mit.edu	37	9	66459908	66459908	+	RNA	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:66459908C>G	ENST00000424345.1	+	0	168																											acattaaaatcttgggcatgc	0.373000													3	24					0	0	0.115264	0	0
PGM1	5236	broad.mit.edu	37	1	64089164	64089164	+	Silent	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:64089164A>T	ENST00000371083.4	+	1	401	c.33A>T	c.(31-33)acA>acT	p.T11T	PGM1_ENST00000540265.1_Intron|PGM1_ENST00000371084.3_Intron	NM_001172818.1	NP_001166289.1	P36871	PGM1_HUMAN	phosphoglucomutase 1	0					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TTTCTGGGACATATAGAAAAA	0.458000													22	105					0	0	0.083992	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291284	141291284	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:141291284C>T	ENST00000247452.3	-	3	837	c.490G>A	c.(490-492)Gag>Aag	p.E164K		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	164	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTCTGCCTCTGTTACAGGC	0.468000										HNSCC(46;0.14)			210	160					0	0	0.139131	0	0
ABCC12	94160	broad.mit.edu	37	16	48162426	48162426	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:48162426C>T	ENST00000311303.3	-	9	1804	c.1459G>A	c.(1459-1461)Gag>Aag	p.E487K	ABCC12_ENST00000416054.1_Missense_Mutation_p.E487K|ABCC12_ENST00000448542.1_Missense_Mutation_p.E487K	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	487	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TCACTTTGCTCCTCTGGGCCA	0.522000													29	99					0	0	0.116897	0	0
TTC7A	57217	broad.mit.edu	37	2	47287969	47287969	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:47287969G>T	ENST00000319190.5	+	19	2582	c.2214G>T	c.(2212-2214)gcG>gcT	p.A738A	TTC7A_ENST00000263737.6_Silent_p.A384A|TTC7A_ENST00000409245.1_Silent_p.A704A|TTC7A_ENST00000394850.2_Silent_p.A762A	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	738							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			AGGAGGCGGCGGGCCTCTTCC	0.607000													9	42					0.000274275	0.00029673	0.047766	1	0
BDH1	622	broad.mit.edu	37	3	197241142	197241142	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:197241142C>T	ENST00000392379.1	-	7	956	c.555G>A	c.(553-555)agG>agA	p.R185R	BDH1_ENST00000392378.2_Silent_p.R185R|BDH1_ENST00000441275.1_Silent_p.R98R|BDH1_ENST00000358186.2_Silent_p.R185R	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	185					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CACCTTTGGCCCTTCGGATGA	0.562000													7	109					0	0	0.029380	0	0
DAAM2	23500	broad.mit.edu	37	6	39851749	39851749	+	Silent	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:39851749T>A	ENST00000538976.1	+	15	2039	c.1857T>A	c.(1855-1857)ccT>ccA	p.P619P	DAAM2_ENST00000398904.2_Silent_p.P619P|RP11-61I13.3_ENST00000607215.1_RNA|DAAM2_ENST00000274867.4_Silent_p.P619P|RP11-61I13.3_ENST00000607675.1_RNA	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	619	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGCGTGTCCCTGGCACCGTAT	0.493000													4	31					0	0	0.184627	0	0
ATR	545	broad.mit.edu	37	3	142257451	142257451	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:142257451C>G	ENST00000350721.4	-	19	3719	c.3598G>C	c.(3598-3600)Gtt>Ctt	p.V1200L	ATR_ENST00000383101.3_Missense_Mutation_p.V1136L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1200					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGGCAGCGAACAAAGCAGTCC	0.378000								Other conserved DNA damage response genes					10	97					0	0	0.069234	0	0
SLC12A1	6557	broad.mit.edu	37	15	48513169	48513169	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:48513169T>A	ENST00000396577.3	+	4	819	c.604T>A	c.(604-606)Tgg>Agg	p.W202R	SLC12A1_ENST00000561031.1_Missense_Mutation_p.W202R|SLC12A1_ENST00000330289.6_Missense_Mutation_p.W202R|SLC12A1_ENST00000558405.1_Missense_Mutation_p.W202R|SLC12A1_ENST00000380993.3_Missense_Mutation_p.W202R	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	202					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TCGCCTCTCCTGGATTGTTGG	0.398000													20	73					0	0	0.234183	0	0
OR14I1	401994	broad.mit.edu	37	1	248845559	248845559	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:248845559G>T	ENST00000342623.3	-	1	70	c.47C>A	c.(46-48)tCt>tAt	p.S16Y		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						CCAGATACCAGAAAACTCCAT	0.453000													32	63					6.90743e-12	8.97804e-12	0.193644	1	0
OR51D1	390038	broad.mit.edu	37	11	4661129	4661129	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:4661129C>T	ENST00000357605.2	+	1	185	c.109C>T	c.(109-111)Cac>Tac	p.H37Y		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCTACCATACACTTTTGGCT	0.527000													36	213					0	0	0.193644	0	0
MAP3K9	4293	broad.mit.edu	37	14	71216701	71216701	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:71216701C>A	ENST00000554752.2	-	4	1098	c.1099G>T	c.(1099-1101)Gcc>Tcc	p.A367S	MAP3K9_ENST00000554146.1_Missense_Mutation_p.A104S|MAP3K9_ENST00000381250.4_Missense_Mutation_p.A367S|MAP3K9_ENST00000553414.1_Missense_Mutation_p.A61S|MAP3K9_ENST00000555993.2_Missense_Mutation_p.A367S			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	367	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		ATAGGAAGGGCGAGTTTGTTC	0.507000													23	43					1.85244e-09	2.3366e-09	0.083992	1	0
OR2T11	127077	broad.mit.edu	37	1	248789751	248789751	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:248789751A>T	ENST00000330803.2	-	1	740	c.679T>A	c.(679-681)Tct>Act	p.S227T		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTTCAGCAGAGGGCATGCGG	0.502000													13	103					0	0	0.119110	0	0
AZGP1	563	broad.mit.edu	37	7	99569382	99569382	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:99569382G>C	ENST00000411734.1	-	2	320	c.315C>G	c.(313-315)taC>taG	p.Y105*	AZGP1_ENST00000292401.4_Nonsense_Mutation_p.Y108*			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	108					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TACTGTCGTTGTAATACTCCA	0.532000													4	76					0	0	0.217242	0	0
STEAP2-AS1	100874100	broad.mit.edu	37	7	89753405	89753405	+	RNA	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:89753405T>A	ENST00000478318.2	-	0	424				DPY19L2P4_ENST00000497063.1_RNA																							TTAGTAAAACTTTGTGAAAAT	0.284000													7	23					0	0	0.047766	0	0
FRMD4A	55691	broad.mit.edu	37	10	13779904	13779904	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:13779904C>A	ENST00000357447.2	-	12	1067	c.699G>T	c.(697-699)ctG>ctT	p.L233L	FRMD4A_ENST00000342409.2_Silent_p.L249L|RP11-353M9.1_ENST00000449462.1_RNA|FRMD4A_ENST00000358621.4_Silent_p.L218L|FRMD4A_ENST00000378503.1_Silent_p.L233L	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	233	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						AGCTCAGGCCCAGCCACCATG	0.468000													8	26					0.00307968	0.00323716	0.038147	1	0
TUSC3	7991	broad.mit.edu	37	8	15480671	15480671	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:15480671G>C	ENST00000382020.4	+	2	429	c.221G>C	c.(220-222)cGa>cCa	p.R74P	TUSC3_ENST00000503731.1_Missense_Mutation_p.R74P|TUSC3_ENST00000509380.1_Missense_Mutation_p.R74P|TUSC3_ENST00000506802.1_Missense_Mutation_p.R74P|TUSC3_ENST00000503191.1_3'UTR	NM_178234.2	NP_839952.1	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3	74					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex		p.R74L(2)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(10)|ovary(2)	28				Colorectal(111;0.113)		GATAAATTCCGAAAATTTATA	0.398000													12	32					0	0	0.119110	0	0
EIF4B	1975	broad.mit.edu	37	12	53431327	53431327	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:53431327G>C	ENST00000262056.9	+	11	1767	c.1441G>C	c.(1441-1443)Gag>Cag	p.E481Q	RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000420463.3_Missense_Mutation_p.E486Q|EIF4B_ENST00000416762.3_Missense_Mutation_p.E442Q	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	481					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						TCCACCAAAGGAGAATGCTTG	0.493000													18	39					0	0	0.219247	0	0
TOB2	10766	broad.mit.edu	37	22	41832725	41832725	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:41832725C>G	ENST00000327492.3	-	2	1331	c.625G>C	c.(625-627)Ggt>Cgt	p.G209R		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	209					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						TGCTGGCCACCCGCCCCACTG	0.612000													7	0					0	0	0.029380	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238994	6238994	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:6238994C>G	ENST00000265978.4	-	9	2222	c.1864G>C	c.(1864-1866)Gaa>Caa	p.E622Q	FAM160A2_ENST00000449352.2_Missense_Mutation_p.E608Q|FAM160A2_ENST00000524416.1_Missense_Mutation_p.E608Q	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	608					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						tcctccccttcccccacgttg	0.667000													9	33					0	0	0.069234	0	0
NUP88	4927	broad.mit.edu	37	17	5314073	5314073	+	Missense_Mutation	SNP	G	G	T	rs144076487		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:5314073G>T	ENST00000573584.1	-	4	1139	c.630C>A	c.(628-630)aaC>aaA	p.N210K		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	210					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						GTATTATCACGTTAGTGGGTG	0.363000													70	182					7.62596e-35	1.15324e-34	0.139131	1	0
ANKRD12	23253	broad.mit.edu	37	18	9258375	9258375	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:9258375C>G	ENST00000383440.2	+	8	5298	c.5041C>G	c.(5041-5043)Caa>Gaa	p.Q1681E	ANKRD12_ENST00000400020.3_Missense_Mutation_p.Q1681E|ANKRD12_ENST00000262126.3_Missense_Mutation_p.Q1704E	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1704						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GCAGTCAACTCAACCAGAAAT	0.348000													9	89					0	0	0.058154	0	0
PTPRD	5789	broad.mit.edu	37	9	8500764	8500764	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:8500764G>T	ENST00000381196.4	-	21	2661	c.2118C>A	c.(2116-2118)acC>acA	p.T706T	PTPRD_ENST00000356435.5_Silent_p.T706T|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000358503.5_Silent_p.T693T|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000540109.1_Silent_p.T706T|PTPRD_ENST00000360074.4_Silent_p.T693T|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000486161.1_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	706	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CATCTTCATTGGTTCGAATCA	0.473000										TSP Lung(15;0.13)			42	73					3.54561e-26	5.23354e-26	0.111260	1	0
HOXC11	3227	broad.mit.edu	37	12	54367588	54367588	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:54367588G>A	ENST00000546378.1	+	1	679	c.563G>A	c.(562-564)gGa>gAa	p.G188E	HOTAIR_ENST00000455246.1_RNA|HOTAIR_ENST00000424518.1_RNA|HOXC11_ENST00000243082.4_Missense_Mutation_p.G188E			O43248	HXC11_HUMAN	homeobox C11	188					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						CCGGCCTCGGGACTGGCGTCC	0.736000			T	NUP98	AML								5	32					0	0	0.217242	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567059	45567059	+	RNA	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:45567059C>A	ENST00000256692.5	-	0	1626					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGAAAGCTTCTTTCCGGTGG	0.502000													19	115					3.70931e-20	5.34719e-20	0.175082	1	0
EEA1	8411	broad.mit.edu	37	12	93170697	93170697	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:93170697T>A	ENST00000322349.8	-	28	4300	c.4036A>T	c.(4036-4038)Aat>Tat	p.N1346Y		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	1346					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						CACTTTCTATTCAACGCTTGT	0.343000													35	131					0	0	0.098360	0	0
HSPBP1	23640	broad.mit.edu	37	19	55776662	55776662	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:55776662T>A	ENST00000255631.5	-	8	1299	c.989A>T	c.(988-990)cAg>cTg	p.Q330L	HSPBP1_ENST00000376343.3_Missense_Mutation_p.Q228L|HSPBP1_ENST00000587922.1_Missense_Mutation_p.Q330L|HSPBP1_ENST00000433386.2_Missense_Mutation_p.Q330L	NM_001130106.1|NM_012267.4	NP_001123578.1|NP_036399.3	Q9NZL4	HPBP1_HUMAN	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	333					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CTCCTCATGCTGCTGCAGCAG	0.662000													6	19					0	0	0.029380	0	0
ABCB5	340273	broad.mit.edu	37	7	20725459	20725459	+	Splice_Site	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:20725459G>T	ENST00000404938.2	+	16	2662	c.2010_splice	c.e16+1	p.E670_splice	ABCB5_ENST00000258738.6_Splice_Site_p.E225_splice	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	225	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AATCTAAAGAGGTAATGGCTC	0.343000													21	64					1.55469e-16	2.18999e-16	0.083992	1	0
TBL1XR1	79718	broad.mit.edu	37	3	176755886	176755886	+	Splice_Site	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:176755886C>A	ENST00000430069.1	-	12	1381	c.1122_splice	c.e12+1	p.K374_splice	TBL1XR1_ENST00000457928.2_Splice_Site_p.K374_splice			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	374					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			AGCAAATTACCTTTAAAGTCA	0.393000													29	73					4.65686e-17	6.61013e-17	0.193644	1	0
ZNF727	442319	broad.mit.edu	37	7	63538757	63538757	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:63538757A>G	ENST00000550760.3	+	4	1509	c.1330A>G	c.(1330-1332)Aga>Gga	p.R444G		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						TAATCATAAGAGAATTCACAC	0.393000													5	27					0	0	0.217242	0	0
SPAG8	26206	broad.mit.edu	37	9	35811203	35811203	+	Missense_Mutation	SNP	G	G	C	rs150971266		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:35811203G>C	ENST00000340291.2	-	2	964	c.840C>G	c.(838-840)tgC>tgG	p.C280W	SPAG8_ENST00000479751.1_5'UTR|SPAG8_ENST00000396638.2_Missense_Mutation_p.C280W|SPAG8_ENST00000484764.1_Missense_Mutation_p.C278W	NM_172312.1	NP_758516.1	Q99932	SPAG8_HUMAN	sperm associated antigen 8	280						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			TGTAGAGGAGGCACTGGCCCC	0.498000													7	85					0	0	0.029380	0	0
ADAM22	53616	broad.mit.edu	37	7	87816014	87816014	+	Silent	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:87816014T>C	ENST00000398209.3	+	29	2599	c.2553T>C	c.(2551-2553)ttT>ttC	p.F851F	ADAM22_ENST00000315984.7_Silent_p.F851F|ADAM22_ENST00000265727.7_Intron|ADAM22_ENST00000398204.4_Intron	NM_021722.4	NP_068368.2	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	859					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GACCATACTTTAGGtatttta	0.348000													32	70					0	0	0.144211	0	0
OR8D1	283159	broad.mit.edu	37	11	124179838	124179838	+	Silent	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:124179838A>G	ENST00000357821.2	-	1	895	c.825T>C	c.(823-825)tcT>tcC	p.S275S		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGTAGAACACAGAGGACACCT	0.453000													32	49					0	0	0.144211	0	0
CAND2	23066	broad.mit.edu	37	3	12858058	12858058	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:12858058G>T	ENST00000456430.2	+	10	1668	c.1627G>T	c.(1627-1629)Gtg>Ttg	p.V543L	CAND2_ENST00000295989.5_Missense_Mutation_p.V450L	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	543					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CGAGGCCCTGGTGGTGCTGCA	0.617000													5	19					2.0095e-06	2.33809e-06	0.029380	1	0
RIMKLA	284716	broad.mit.edu	37	1	42880470	42880470	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:42880470G>T	ENST00000431473.3	+	5	1130	c.1001G>T	c.(1000-1002)gGa>gTa	p.G334V		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	334					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						TCAGCTCAGGGAGTTGCAGAG	0.547000													13	43					0.000219431	0.000240681	0.119110	1	0
ACIN1	22985	broad.mit.edu	37	14	23532768	23532768	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:23532768G>A	ENST00000262710.1	-	13	3115	c.2788C>T	c.(2788-2790)Cag>Tag	p.Q930*	ACIN1_ENST00000557515.1_Nonsense_Mutation_p.Q171*|ACIN1_ENST00000338631.6_Nonsense_Mutation_p.Q203*|ACIN1_ENST00000605057.1_Nonsense_Mutation_p.Q872*|ACIN1_ENST00000555053.1_Nonsense_Mutation_p.Q917*|ACIN1_ENST00000357481.2_Nonsense_Mutation_p.Q172*|ACIN1_ENST00000457657.1_Nonsense_Mutation_p.Q890*|ACIN1_ENST00000397341.3_Nonsense_Mutation_p.Q172*	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	930					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CCATTCTCCTGGCCCTCTGCA	0.532000													30	79					0	0	0.183431	0	0
CA8	767	broad.mit.edu	37	8	61144930	61144930	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:61144930C>T	ENST00000317995.4	-	4	690	c.426G>A	c.(424-426)ctG>ctA	p.L142L	CA8_ENST00000528666.1_5'UTR	NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	142					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				TCCAGTGGATCAGATGGAGCT	0.443000													38	70					0	0	0.235728	0	0
XIRP2	129446	broad.mit.edu	37	2	168100623	168100623	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:168100623G>T	ENST00000409195.1	+	9	2810	c.2721G>T	c.(2719-2721)ggG>ggT	p.G907G	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.G907G|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Silent_p.G685G|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	732					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGAAAAAGGGGATGTTAGGC	0.358000													6	65					0.00116845	0.00124231	0.217242	1	0
SYTL5	94122	broad.mit.edu	37	X	37913577	37913577	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:37913577G>T	ENST00000357972.5	+	3	777	c.231G>T	c.(229-231)cgG>cgT	p.R77R	SYTL5_ENST00000456733.2_Silent_p.R77R|TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000297875.2_Silent_p.R77R			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	77	RabBD.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						TCTTTGACCGGGGAGACCCTT	0.512000													15	31					2.32078e-09	2.91411e-09	0.132662	1	0
PZP	5858	broad.mit.edu	37	12	9317845	9317845	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:9317845G>T	ENST00000261336.2	-	19	2405	c.2377C>A	c.(2377-2379)Cga>Aga	p.R793R	PZP_ENST00000381997.2_Silent_p.R662R|PZP_ENST00000539983.1_5'UTR	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TGGAAGGCTCGGAGAGAGGCA	0.547000													4	242					0.150653	0.152578	0.150653	1	0
SKIL	6498	broad.mit.edu	37	3	170110049	170110049	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:170110049G>T	ENST00000458537.3	+	6	2608	c.1899G>T	c.(1897-1899)ttG>ttT	p.L633F	SKIL_ENST00000426052.2_Missense_Mutation_p.L613F|SKIL_ENST00000413427.2_Missense_Mutation_p.L587F|SKIL_ENST00000259119.4_Missense_Mutation_p.L633F	NM_001145097.2|NM_001248008.1|NM_005414.4	NP_001138569.1|NP_001234937.1|NP_005405.2	P12757	SKIL_HUMAN	SKI-like oncogene	633					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	25	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TCACATAGTTGGCAGAACTGA	0.363000													6	90					0.00116845	0.00124231	0.217242	1	0
ITGB8	3696	broad.mit.edu	37	7	20449250	20449250	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:20449250G>C	ENST00000222573.3	+	13	2720	c.2036G>C	c.(2035-2037)aGc>aCc	p.S679T	ITGB8_ENST00000537992.1_Missense_Mutation_p.S544T	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	679					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						TGTTTCTCCAGCCCAAGCTAC	0.303000													15	73					0	0	0.132662	0	0
CSMD1	64478	broad.mit.edu	37	8	2857579	2857579	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:2857579C>A	ENST00000602557.1	-	54	8662	c.8107G>T	c.(8107-8109)Gtg>Ttg	p.V2703L	CSMD1_ENST00000602723.1_Missense_Mutation_p.V2645L|CSMD1_ENST00000542608.1_Missense_Mutation_p.V2644L|CSMD1_ENST00000520002.1_Missense_Mutation_p.V2703L|CSMD1_ENST00000537824.1_Missense_Mutation_p.V2702L|CSMD1_ENST00000400186.3_Missense_Mutation_p.V2645L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2703	Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGTAAACCACCGTGTCTCTG	0.498000													65	94					1.55545e-33	2.34585e-33	0.139131	1	0
CACNA1C	775	broad.mit.edu	37	12	2786943	2786943	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:2786943G>A	ENST00000399655.1	+	41	5266	c.5001G>A	c.(4999-5001)cgG>cgA	p.R1667R	CACNA1C_ENST00000399644.1_Silent_p.R1667R|CACNA1C_ENST00000399634.1_Silent_p.R1667R|CACNA1C_ENST00000399621.1_Silent_p.R1686R|CACNA1C_ENST00000399617.1_Silent_p.R1667R|CACNA1C_ENST00000399597.1_Silent_p.R1667R|CACNA1C_ENST00000327702.7_Silent_p.R1667R|CACNA1C_ENST00000399595.1_Silent_p.R1675R|CACNA1C_ENST00000347598.4_Silent_p.R1715R|CACNA1C_ENST00000399601.1_Silent_p.R1667R|CACNA1C_ENST00000406454.3_Silent_p.R1667R|CACNA1C_ENST00000399606.1_Silent_p.R1687R|CACNA1C_ENST00000399638.1_Silent_p.R1695R|CACNA1C_ENST00000399641.1_Silent_p.R1667R|CACNA1C_ENST00000399637.1_Silent_p.R1686R|CACNA1C_ENST00000335762.5_Silent_p.R1692R|CACNA1C_ENST00000344100.3_Silent_p.R1708R|CACNA1C_ENST00000399649.1_Silent_p.R1673R|CACNA1C_ENST00000399603.1_Silent_p.R1667R|CACNA1C_ENST00000399629.1_Silent_p.R1684R|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000402845.3_Silent_p.R1686R|CACNA1C_ENST00000399591.1_Silent_p.R1675R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1715					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGATCCGACGGGCCATCTCTG	0.602000													12	46					0	0	0.080935	0	0
CDH6	1004	broad.mit.edu	37	5	31299654	31299654	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:31299654G>C	ENST00000265071.2	+	5	992	c.727G>C	c.(727-729)Ggc>Cgc	p.G243R	CDH6_ENST00000514738.1_Missense_Mutation_p.G188R	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	243	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.G243S(2)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GGATATGGGCGGCCAGATGGG	0.483000													17	61					0	0	0.160694	0	0
GPC5	2262	broad.mit.edu	37	13	92346033	92346033	+	Missense_Mutation	SNP	G	G	T	rs140805446		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:92346033G>T	ENST00000377067.3	+	3	1290	c.918G>T	c.(916-918)atG>atT	p.M306I		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	306						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CGGATGCAATGCATGGAACAT	0.483000													29	44					2.08457e-15	2.88513e-15	0.153744	1	0
FAP	2191	broad.mit.edu	37	2	163030271	163030271	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:163030271C>A	ENST00000188790.4	-	23	2203	c.1996G>T	c.(1996-1998)Ggt>Tgt	p.G666C	FAP_ENST00000443424.1_Missense_Mutation_p.G641C	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	666					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GTTGGGAGACCCATGAATCTC	0.308000													38	109					4.01344e-20	5.77062e-20	0.139131	1	0
TRANK1	9881	broad.mit.edu	37	3	36897786	36897786	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:36897786C>A	ENST00000429976.2	-	12	3542	c.3295G>T	c.(3295-3297)Gat>Tat	p.D1099Y	TRANK1_ENST00000428977.2_Missense_Mutation_p.D549Y|TRANK1_ENST00000301807.6_Missense_Mutation_p.D549Y			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1099	Glu-rich.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TCAATAGAAtcttcctcttcc	0.557000													11	32					2.27111e-07	2.74611e-07	0.093190	1	0
DOCK1	1793	broad.mit.edu	37	10	129224177	129224177	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:129224177A>T	ENST00000280333.6	+	47	4862	c.4753A>T	c.(4753-4755)Aaa>Taa	p.K1585*		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1585	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCATGGAGACAAAGTCACGGA	0.493000													33	137					0	0	0.193644	0	0
ZNF257	113835	broad.mit.edu	37	19	22255680	22255680	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:22255680C>G	ENST00000594947.1	+	2	217	c.73C>G	c.(73-75)Cag>Gag	p.Q25E	ZNF257_ENST00000600162.1_Missense_Mutation_p.Q25E	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGACACTGCACAGCAGAATTT	0.428000													25	84					0	0	0.083992	0	0
LRTM2	654429	broad.mit.edu	37	12	1940215	1940215	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:1940215C>G	ENST00000543818.1	+	4	1024	c.182C>G	c.(181-183)aCg>aGg	p.T61R	LRTM2_ENST00000535041.1_Missense_Mutation_p.T61R|CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000543730.1_Intron|LRTM2_ENST00000299194.1_Missense_Mutation_p.T61R|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000588077.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	61	LRRNT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GGCCTCACCACGGTGCCCCCA	0.637000													22	72					0	0	0.219247	0	0
SNX2	6643	broad.mit.edu	37	5	122161790	122161790	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:122161790G>T	ENST00000379516.2	+	12	1366	c.1258G>T	c.(1258-1260)Gct>Tct	p.A420S	SNX2_ENST00000514949.1_Missense_Mutation_p.A303S|SNX2_ENST00000510372.1_3'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	420					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		ATGGGAAGATGCTCAAATTAC	0.338000													10	36					0.000978159	0.00104803	0.080935	1	0
ETS1	2113	broad.mit.edu	37	11	128359204	128359204	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:128359204A>T	ENST00000392668.3	-	5	584	c.516T>A	c.(514-516)caT>caA	p.H172Q	ETS1_ENST00000535549.1_Intron|ETS1_ENST00000319397.5_Missense_Mutation_p.H128Q|ETS1_ENST00000531611.1_Missense_Mutation_p.H128Q|ETS1_ENST00000526145.1_Missense_Mutation_p.H128Q|ETS1_ENST00000345075.4_Missense_Mutation_p.H128Q	NM_001143820.1	NP_001137292.1	P14921	ETS1_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 1	128					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GGATCTCTAGATGTTCCCATA	0.517000													35	512					0	0	0.203993	0	0
STK31	56164	broad.mit.edu	37	7	23827750	23827750	+	Splice_Site	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:23827750T>A	ENST00000354639.3	+	21	3032		c.e21+2		STK31_ENST00000428484.1_Splice_Site|STK31_ENST00000405627.3_Splice_Site|STK31_ENST00000433467.2_Splice_Site|STK31_ENST00000355870.3_Splice_Site	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31								ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAATCTGTGGTAAGATATCAT	0.294000													14	20					0	0	0.119110	0	0
ADAM2	2515	broad.mit.edu	37	8	39626920	39626920	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:39626920C>A	ENST00000265708.4	-	12	1306	c.1203G>T	c.(1201-1203)ggG>ggT	p.G401G	ADAM2_ENST00000521880.1_Silent_p.G401G|ADAM2_ENST00000347580.4_Silent_p.G382G|ADAM2_ENST00000379853.2_Silent_p.G275G	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	401	Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CCTGTTCAGTCCCACAGTCAC	0.428000													13	26					2.62699e-14	3.54739e-14	0.132662	1	0
SERPINA3	12	broad.mit.edu	37	14	95081196	95081196	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:95081196G>T	ENST00000553947.1	+	5	1381	c.493G>T	c.(493-495)Gcc>Tcc	p.A165S	SERPINA3_ENST00000393080.4_Missense_Mutation_p.A140S|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393078.3_Missense_Mutation_p.A140S|SERPINA3_ENST00000467132.1_Missense_Mutation_p.A140S			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	140					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TATGGGAAATGCCATGTTTGT	0.547000													13	41					4.3838e-07	5.24355e-07	0.105934	1	0
OR4S1	256148	broad.mit.edu	37	11	48328563	48328563	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:48328563G>T	ENST00000319988.1	+	1	789	c.789G>T	c.(787-789)ctG>ctT	p.L263L		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						CCACCACCCTGGCTGCTGACA	0.473000													43	95					2.52991e-16	3.55468e-16	0.139131	1	0
CUBN	8029	broad.mit.edu	37	10	17157575	17157575	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:17157575C>A	ENST00000377833.4	-	7	680	c.615G>T	c.(613-615)acG>acT	p.T205T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	205	EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGGGTCCGTACGTCTCAGGTG	0.512000													4	54					0.00909568	0.0094181	0.150653	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144879555	144879555	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:144879555C>A	ENST00000369359.4	-	30	4341	c.4303G>T	c.(4303-4305)Gag>Tag	p.E1435*	PDE4DIP_ENST00000369356.4_Nonsense_Mutation_p.E1299*|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.E1435*|PDE4DIP_ENST00000369354.3_Nonsense_Mutation_p.E1299*|PDE4DIP_ENST00000313382.9_Nonsense_Mutation_p.E1255*			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1299					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGTTGTGCTCCTCACACTCT	0.522000			T	PDGFRB	MPD								7	74					0.000442599	0.000477904	0.058154	1	0
CHD4	1108	broad.mit.edu	37	12	6711247	6711247	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:6711247T>C	ENST00000309577.6	-	4	480	c.317A>G	c.(316-318)gAg>gGg	p.E106G	CHD4_ENST00000544040.1_Missense_Mutation_p.E99G|CHD4_ENST00000544484.1_Missense_Mutation_p.E103G|CHD4_ENST00000357008.2_Missense_Mutation_p.E106G			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	106					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GTCGCTGCCCTCACTGTCTGA	0.567000													26	59					0	0	0.116897	0	0
ZNF667	63934	broad.mit.edu	37	19	56953955	56953955	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:56953955C>A	ENST00000504904.3	-	7	1128	c.409G>T	c.(409-411)Ggg>Tgg	p.G137W	ZNF667_ENST00000342634.3_Missense_Mutation_p.G265W|ZNF667_ENST00000292069.6_Missense_Mutation_p.G137W|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CCTGAATGCCCTTTCTTAGGT	0.393000													6	40					8.12818e-05	9.02228e-05	0.029380	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90501374	90501374	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:90501374G>T	ENST00000325643.5	+	4	2038	c.1972G>T	c.(1972-1974)Ggg>Tgg	p.G658W		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ACAGCCTGATGGGGAATTCCC	0.617000													8	45					0.0477658	0.0488214	0.047766	1	0
FKBP11	51303	broad.mit.edu	37	12	49318374	49318374	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:49318374T>A	ENST00000550765.1	-	3	651	c.253A>T	c.(253-255)Ata>Tta	p.I85L	ARF3_ENST00000398092.4_Intron|AC073610.5_ENST00000537495.1_Intron|CCDC65_ENST00000266984.5_Intron|FKBP11_ENST00000552878.1_Missense_Mutation_p.I85L|FKBP11_ENST00000453172.2_Missense_Mutation_p.I85L|FKBP11_ENST00000444214.2_5'UTR	NM_016594.2	NP_057678.1	Q9NYL4	FKB11_HUMAN	FK506 binding protein 11, 19 kDa	85	PPIase FKBP-type.				protein folding	integral to membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			kidney(1)|large_intestine(3)|lung(1)	5						CCAAGTTCTATAACCAGAGGG	0.517000											OREG0021773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	65					0	0	0.099896	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124236931	124236931	+	Silent	SNP	A	A	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:124236931A>G	ENST00000330342.3	+	17	2405	c.2157A>G	c.(2155-2157)agA>agG	p.R719R		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	719					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ATGGATGTAGAGAAATGGCGT	0.363000													10	55					0	0	0.069234	0	0
ZFP82	284406	broad.mit.edu	37	19	36884638	36884638	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:36884638C>A	ENST00000392161.3	-	5	846	c.604G>T	c.(604-606)Gaa>Taa	p.E202*	ZFP82_ENST00000392171.1_Nonsense_Mutation_p.E202*	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATCCCACATTCCTTACATTCA	0.433000													17	64					2.48551e-13	3.28442e-13	0.160694	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55341597	55341597	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:55341597T>C	ENST00000391728.4	+	9	1235	c.1202T>C	c.(1201-1203)tTg>tCg	p.L401S	KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.L384S|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.L306S|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.L384S|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.L401S	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		TACGCACAGTTGGATCACTGC	0.517000													45	352					0	0	0.139131	0	0
VCAN	1462	broad.mit.edu	37	5	82816104	82816104	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:82816104G>T	ENST00000265077.3	+	7	2544	c.1979G>T	c.(1978-1980)gGt>gTt	p.G660V	VCAN_ENST00000343200.5_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.G612V|VCAN_ENST00000342785.4_Missense_Mutation_p.G660V|VCAN_ENST00000502527.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	660	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCTTATTCTGGTGATAAAATA	0.353000													11	47					1.58986e-06	1.86155e-06	0.069234	1	0
ESRP1	54845	broad.mit.edu	37	8	95686684	95686684	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:95686684G>T	ENST00000433389.2	+	12	1791	c.1601G>T	c.(1600-1602)gGg>gTg	p.G534V	ESRP1_ENST00000423620.2_Missense_Mutation_p.G534V|ESRP1_ENST00000454170.2_Missense_Mutation_p.G534V|ESRP1_ENST00000358397.5_Missense_Mutation_p.G534V	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	534					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						GTGTTAATGGGGGGCACTTTA	0.418000													13	21					2.27111e-07	2.74611e-07	0.093190	1	0
SNX2	6643	broad.mit.edu	37	5	122161791	122161791	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:122161791C>G	ENST00000379516.2	+	12	1367	c.1259C>G	c.(1258-1260)gCt>gGt	p.A420G	SNX2_ENST00000514949.1_Missense_Mutation_p.A303G|SNX2_ENST00000510372.1_3'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	420					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		TGGGAAGATGCTCAAATTACT	0.343000													11	36					0	0	0.093190	0	0
TRAV14DV4	28669	broad.mit.edu	37	14	22392792	22392792	+	RNA	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:22392792G>A	ENST00000390440.2	+	0	390																											CACAACTGGGGGACTCAGCAA	0.507000													70	190					0	0	0.139131	0	0
LIPN	643418	broad.mit.edu	37	10	90537933	90537933	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:90537933C>T	ENST00000404459.1	+	9	1131	c.1131C>T	c.(1129-1131)gtC>gtT	p.V377V		NM_001102469.1	NP_001095939.1	Q5VXI9	LIPN_HUMAN	lipase, family member N	377					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|skin(1)	9		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		TTGATTTTGTCTGGGGCCTCG	0.413000													7	21					0	0	0.029380	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21051394	21051394	+	Silent	SNP	A	A	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:21051394A>T	ENST00000381545.3	+	14	1926	c.1707A>T	c.(1705-1707)gcA>gcT	p.A569A	LST3_ENST00000540229.1_Silent_p.A569A|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000261196.2_Silent_p.A569A|SLCO1B3_ENST00000553473.1_Silent_p.A569A	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	569					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					AATTGAAAGCACTTGCAATGG	0.254000													7	29					0	0	0.047766	0	0
ZBP1	81030	broad.mit.edu	37	20	56186875	56186875	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:56186875A>C	ENST00000340462.4	-	5	993	c.713T>G	c.(712-714)cTg>cGg	p.L238R	ZBP1_ENST00000371173.3_Missense_Mutation_p.L261R|ZBP1_ENST00000395822.3_Missense_Mutation_p.L186R|ZBP1_ENST00000343535.4_Missense_Mutation_p.L261R			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	261						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CACCCGTCTCAGTATGGACTG	0.642000													4	12					0	0	0.184627	0	0
CSMD3	114788	broad.mit.edu	37	8	113871484	113871484	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:113871484C>A	ENST00000297405.5	-	11	1889	c.1645G>T	c.(1645-1647)Ggc>Tgc	p.G549C	CSMD3_ENST00000352409.3_Missense_Mutation_p.G549C|CSMD3_ENST00000455883.2_Missense_Mutation_p.G445C|CSMD3_ENST00000343508.3_Missense_Mutation_p.G509C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	549	CUB 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGATTAGAGCCACACGTTTTC	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			31	33					8.88839e-20	1.27141e-19	0.153744	1	0
NVL	4931	broad.mit.edu	37	1	224491431	224491431	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:224491431A>C	ENST00000281701.6	-	9	1213	c.954T>G	c.(952-954)atT>atG	p.I318M	NVL_ENST00000391875.2_Missense_Mutation_p.I212M|NVL_ENST00000482491.1_Missense_Mutation_p.L15W|NVL_ENST00000469075.1_Missense_Mutation_p.I227M|NVL_ENST00000340871.4_Missense_Mutation_p.I102M|NVL_ENST00000361463.3_Missense_Mutation_p.I212M	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	318						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		TCACCCCAGCAATTGCATGTG	0.478000													22	24					0	0	0.099896	0	0
AGAP3	116988	broad.mit.edu	37	7	150814462	150814462	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:150814462G>C	ENST00000397238.2	+	4	483	c.483G>C	c.(481-483)ggG>ggC	p.G161G	AGAP3_ENST00000479901.1_Silent_p.G161G|AGAP3_ENST00000463381.1_5'UTR|AGAP3_ENST00000476375.1_3'UTR|AGAP3_ENST00000335367.3_Silent_p.G341G|AGAP3_ENST00000473312.1_Silent_p.G161G	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	125	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						TCCTAGGGGGGCGGTTTAAGA	0.582000													45	189					0	0	0.139131	0	0
RP5-1063M23.2	0	broad.mit.edu	37	12	3432969	3432969	+	RNA	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:3432969C>T	ENST00000432994.2	+	0	1464																											gcATATGAGGCGGGGAGAAAT	0.512000													4	11					0	0	0.150653	0	0
RYR2	6262	broad.mit.edu	37	1	237819147	237819147	+	Silent	SNP	G	G	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:237819147G>A	ENST00000366574.2	+	53	8309	c.7992G>A	c.(7990-7992)ctG>ctA	p.L2664L	RYR2_ENST00000360064.6_Silent_p.L2662L|RYR2_ENST00000542537.1_Silent_p.L2648L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2664	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTCAAACTGGCACTGCCTT	0.408000													8	13					0	0	0.047766	0	0
EXOC6	54536	broad.mit.edu	37	10	94679738	94679738	+	Splice_Site	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:94679738G>T	ENST00000371552.4	+	8	833		c.e8-1		EXOC6_ENST00000260762.6_Splice_Site|EXOC6_ENST00000443748.2_Intron|EXOC6_ENST00000371547.4_Splice_Site	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6						protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTAATTTTCAGATCTTAACTG	0.269000													3	6					0.004672	0.00487398	0.115264	1	0
KEL	3792	broad.mit.edu	37	7	142651423	142651423	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:142651423C>A	ENST00000355265.2	-	8	1246	c.772G>T	c.(772-774)Gga>Tga	p.G258*	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	258					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AGCAAGGTTCCCAGCTGATTC	0.537000													23	82					1.55469e-16	2.18999e-16	0.083992	1	0
TRPC5	7224	broad.mit.edu	37	X	111155676	111155676	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:111155676C>A	ENST00000262839.2	-	3	1661	c.743G>T	c.(742-744)tGc>tTc	p.C248F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	248					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAAGAGCTTGCACTGCTGAGA	0.557000													89	70					3.90494e-43	5.93765e-43	0.139131	1	0
FAM161A	84140	broad.mit.edu	37	2	62067078	62067078	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:62067078C>A	ENST00000404929.1	-	3	1072	c.1061G>T	c.(1060-1062)cGa>cTa	p.R354L	FAM161A_ENST00000405894.3_Missense_Mutation_p.R354L	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	354					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGCTTTAAATCGATTTGTTTT	0.398000													19	55					2.27731e-05	2.55851e-05	0.234183	1	0
ZNF808	388558	broad.mit.edu	37	19	53050824	53050824	+	Silent	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:53050824G>C	ENST00000359798.4	+	4	303	c.123G>C	c.(121-123)ctG>ctC	p.L41L		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GGAAATTCCTGAACCCTGCAC	0.458000													59	307					0	0	0.139131	0	0
IL10	3586	broad.mit.edu	37	1	206945637	206945637	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:206945637G>T	ENST00000423557.1	-	1	202	c.144C>A	c.(142-144)ttC>ttA	p.F48L		NM_000572.2	NP_000563.1	P22301	IL10_HUMAN	interleukin 10	48					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding			endometrium(1)|large_intestine(6)|lung(4)|prostate(1)	12	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			TCACTCTGCTGAAGGCATCTC	0.537000													18	36					7.45023e-12	9.66092e-12	0.219247	1	0
ITGA2B	3674	broad.mit.edu	37	17	42452120	42452120	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:42452120C>A	ENST00000262407.5	-	28	2881	c.2850G>T	c.(2848-2850)ctG>ctT	p.L950L	ITGA2B_ENST00000353281.4_Intron	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	950					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CAAACTGATCCAGAGGCCTCT	0.632000													4	16					0.000602214	0.000647731	0.184627	1	0
NCAPG	64151	broad.mit.edu	37	4	17816939	17816939	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:17816939C>G	ENST00000251496.2	+	5	909	c.733C>G	c.(733-735)Cag>Gag	p.Q245E		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	245					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		GTCCATTGCTCAGAGAGTAAT	0.303000													5	22					0	0	0.029380	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610673	50610673	+	Silent	SNP	C	C	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:50610673C>A	ENST00000371824.1	+	2	311	c.54C>A	c.(52-54)tcC>tcA	p.S18S	ELAVL4_ENST00000448907.2_Silent_p.S21S|ELAVL4_ENST00000371821.1_Silent_p.S23S|ELAVL4_ENST00000371827.1_Silent_p.S18S|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371823.4_Silent_p.S18S|ELAVL4_ENST00000371819.1_Silent_p.S23S|ELAVL4_ENST00000357083.4_Silent_p.S35S			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	18					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						GTCCGACATCCAATACAAGCA	0.418000													15	84					1.3612e-06	1.60397e-06	0.132662	1	0
PREX1	57580	broad.mit.edu	37	20	47266653	47266653	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:47266653G>C	ENST00000396220.1	-	24	2931	c.2909C>G	c.(2908-2910)aCc>aGc	p.T970S	PREX1_ENST00000371941.3_Missense_Mutation_p.T970S			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	970					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GTGGCAATTGGTGGGGCAGAA	0.597000													30	69					0	0	0.203993	0	0
CDK20	23552	broad.mit.edu	37	9	90588911	90588911	+	Silent	SNP	G	G	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:90588911G>T	ENST00000375883.3	-	2	421	c.115C>A	c.(115-117)Cgg>Agg	p.R39R	CDK20_ENST00000375871.4_Silent_p.R39R|CDK20_ENST00000325303.8_Silent_p.R39R|CDK20_ENST00000605159.1_Silent_p.R39R|CDK20_ENST00000336654.5_Silent_p.R52R	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	39	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TCCTCCAACCGCCTTAGGGCC	0.587000													5	76					1.23904e-05	1.40627e-05	0.184627	1	0
CHRDL1	91851	broad.mit.edu	37	X	109937401	109937401	+	Silent	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:109937401C>T	ENST00000218054.4	-	8	961	c.765G>A	c.(763-765)aaG>aaA	p.K255K	CHRDL1_ENST00000482160.1_Silent_p.K176K|CHRDL1_ENST00000372042.1_Silent_p.K256K|CHRDL1_ENST00000394797.4_Silent_p.K255K|CHRDL1_ENST00000372045.1_Silent_p.K249K|CHRDL1_ENST00000444321.2_Silent_p.K255K|CHRDL1_ENST00000434224.1_Silent_p.K176K	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	249	VWFC 3.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						CTTGTCCATGCTTGTGTTTGT	0.507000													49	55					0	0	0.139131	0	0
C6	729	broad.mit.edu	37	5	41161794	41161794	+	Splice_Site	SNP	C	C	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:41161794C>T	ENST00000263413.3	-	10	1723		c.e10+1		C6_ENST00000337836.5_Splice_Site|C6_ENST00000475349.1_Splice_Site	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6						complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTACTCTTACCTCAAAGTCA	0.398000													22	46					0	0	0.234183	0	0
ESPNP	284729	broad.mit.edu	37	1	17031938	17031939	+	RNA	INS	-	-	TC	rs148205307		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:17031938_17031939insTC	ENST00000492551.1	-	0	696					NR_026567.1																						tCAAAttttttttttttttttt	0.465													3	4	---	---	---	---					
LOC101928460	101928460	broad.mit.edu	37	1	29666679	29666679	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:29666679delT	ENST00000417651.1	-	0	432																											attctttttcttttttttttt	0.403													3	3	---	---	---	---					
RP5-1180C18.1	0	broad.mit.edu	37	1	37749571	37749572	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:37749571_37749572insA	ENST00000413901.1	-	0	111																											ggtaacttgacaaaaaacaaaa	0.436													2	4	---	---	---	---					
RP5-1180C18.1	0	broad.mit.edu	37	1	37777547	37777550	+	RNA	DEL	CACA	CACA	-	rs66993360		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:37777547_37777550delCACA	ENST00000413901.1	-	0	111																											GAGCTGTTATcacacacacacaca	0.529													2	4	---	---	---	---					
FAAHP1	729041	broad.mit.edu	37	1	46910401	46910401	+	RNA	DEL	C	C	-	rs34199645		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:46910401delC	ENST00000429784.2	+	0	454					NR_045483.1																						GGTTTGAATTCCTACAAGGAC	0.473													4	4	---	---	---	---					
LINC01359	101927084	broad.mit.edu	37	1	65440769	65440770	+	RNA	INS	-	-	T	rs111582090		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:65440769_65440770insT	ENST00000447748.1	-	0	1775																											attttgtatagttttttttttt	0.455													4	3	---	---	---	---					
LINC01362	103283057	broad.mit.edu	37	1	83579165	83579174	+	RNA	DEL	TGTGTGTGTG	TGTGTGTGTG	-	rs66784872		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:83579165_83579174delTGTGTGTGTG	ENST00000452901.1	+	0	1539																											AACCTTGGCCtgtgtgtgtgtgtgtgtgtg	0.410													3	3	---	---	---	---					
LOC100129620	100129620	broad.mit.edu	37	1	99573028	99573028	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:99573028delA	ENST00000425113.1	+	0	370					NR_033940.1																						tgtcccacccaaatctcgtgt	0.438													2	4	---	---	---	---					
GSTM5	2949	broad.mit.edu	37	1	110311224	110311225	+	RNA	INS	-	-	GCC	rs139734137	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:110311224_110311225insGCC	ENST00000431955.1	+	0	627																											CTCCCATCCCTGCCCCTGCTTT	0.604													3	3	---	---	---	---					
LOC440600	440600	broad.mit.edu	37	1	110831157	110831158	+	RNA	INS	-	-	T	rs140028190		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:110831157_110831158insT	ENST00000449169.1	-	0	449_450					NR_036595.1																						ccaatttctcctttttataagg	0.421													2	4	---	---	---	---					
CHIAP2	149620	broad.mit.edu	37	1	111824826	111824827	+	RNA	INS	-	-	A	rs74360455	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:111824826_111824827insA	ENST00000369743.4	+	0	710_711					NR_003928.1																						aaagtatatttaaaaaaaaaaC	0.371													3	3	---	---	---	---					
LOC100996251	100996251	broad.mit.edu	37	1	113607033	113607039	+	RNA	DEL	GCAGGAG	GCAGGAG	-	rs72036287		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:113607033_113607039delGCAGGAG	ENST00000421157.1	-	0	167					NR_103777.1																						agaggcagaagcaggaggcaggaggca	0.565													4	2	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142663276	142663277	+	RNA	DEL	AA	AA	-	rs61807144		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:142663276_142663277delAA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							CATTTTTAGCAAAGTTGTTGCA	0.540													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142676122	142676123	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:142676122_142676123insC	ENST00000369381.2	-	0	2507																											tgaaagttctgccccctaccac	0.460													2	4	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	144007216	144007217	+	RNA	INS	-	-	A	rs113349318		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:144007216_144007217insA	ENST00000467933.1	+	0	915																											catgcaccacccccccagctaa	0.540													3	5	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	144024729	144024742	+	RNA	DEL	TTTTTTTGTTGTTG	TTTTTTTGTTGTTG	-	rs67150523	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:144024729_144024742delTTTTTTTGTTGTTG	ENST00000467933.1	+	0	1108																											ttttttgttttttttttgttgttgttgttgttgt	0.364													4	5	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152225425	152225432	+	RNA	DEL	TTGGCAAA	TTGGCAAA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:152225425_152225432delTTGGCAAA	ENST00000382265.3	+	0	116				FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA																							gggcacagtgttggcaaattgctgctgg	0.500													3	3	---	---	---	---					
LOC101928673	101928673	broad.mit.edu	37	1	173429147	173429148	+	RNA	INS	-	-	AAGC	rs144970854	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:173429147_173429148insAAGC	ENST00000367716.3	-	0	985																											ccagccaagggaagcagtgagt	0.554													8	4	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182227249	182227252	+	RNA	DEL	TTTC	TTTC	-	rs10565494		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr1:182227249_182227252delTTTC	ENST00000449842.1	-	0	410																											TCAGAATAATtttctttctttctt	0.441													3	3	---	---	---	---					
LINC00299	339789	broad.mit.edu	37	2	8423583	8423584	+	RNA	DEL	TT	TT	-	rs78251648		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:8423583_8423584delTT	ENST00000442956.1	-	0	1367																											CTTCTGTCCCtttttttttttt	0.450													2	4	---	---	---	---					
AC010145.4	0	broad.mit.edu	37	2	16145381	16145382	+	RNA	INS	-	-	CTTCTT	rs144182607	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:16145381_16145382insCTTCTT	ENST00000422415.2	-	0	152																											ttcttcttctcctcctcctcct	0.564													3	3	---	---	---	---					
AC010145.4	0	broad.mit.edu	37	2	16146379	16146380	+	RNA	INS	-	-	ACACACAA	rs144634691		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:16146379_16146380insACACACAA	ENST00000422415.2	-	0	152																											cagacacacacacacacacaca	0.455													2	4	---	---	---	---					
AC010145.4	0	broad.mit.edu	37	2	16190089	16190089	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:16190089delT	ENST00000422415.2	-	0	152																											GGCAAGGAGGTTTTTTTGAGA	0.438													2	4	---	---	---	---					
AC008069.1	0	broad.mit.edu	37	2	16920922	16920923	+	RNA	INS	-	-	CATG			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:16920922_16920923insCATG	ENST00000448650.1	+	0	56																											GTTACTGTTCCCATGCATGCTC	0.495													2	4	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34110020	34110021	+	RNA	DEL	TG	TG	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:34110020_34110021delTG	ENST00000366209.2	+	0	134																											tgtgggtgcctgtgtgtgtgtg	0.465													2	4	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34427438	34427439	+	RNA	INS	-	-	T	rs5830296	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:34427438_34427439insT	ENST00000366209.2	+	0	389																											GAAACCAGCAAGTAAAGATAAA	0.391													3	3	---	---	---	---					
CYP1B1-AS1	285154	broad.mit.edu	37	2	38385543	38385543	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:38385543delA	ENST00000413828.2	+	0	190					NR_027252.1																						TTTGGGAAACAAAAAAAATAC	0.473													2	4	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40150466	40150467	+	RNA	INS	-	-	G	rs67004848	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:40150466_40150467insG	ENST00000418854.1	+	0	132				SLC8A1-AS1_ENST00000599740.1_RNA																							GCAGGAAATGTGGGGGGGGTGG	0.475													5	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51795761	51795765	+	RNA	DEL	TATCT	TATCT	-	rs61081601		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:51795761_51795765delTATCT	ENST00000440698.1	+	0	753																											ctgtttatcctatcttgtgtgttct	0.307													3	5	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52607658	52607659	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:52607658_52607659insC	ENST00000440698.1	+	0	2999				AC087073.1_ENST00000435357.1_lincRNA																							ccacgtattggcccccagcagg	0.530													2	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58935270	58935270	+	RNA	DEL	T	T	-	rs75521116		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:58935270delT	ENST00000452840.1	+	0	257																											ATTGAGTTAATTTTTTTTTTT	0.303													2	4	---	---	---	---					
AC007131.2	0	broad.mit.edu	37	2	59570479	59570479	+	RNA	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:59570479delC	ENST00000444001.2	-	0	474				RP11-444A22.1_ENST00000606382.1_lincRNA																							agggattcatccccagagatt	0.378													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65865822	65865822	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:65865822delT	ENST00000420724.1	-	0	63				AC074391.1_ENST00000377977.3_lincRNA																							AACCACCCCCTTTTGAGCAAC	0.433													2	4	---	---	---	---					
AC010987.5	0	broad.mit.edu	37	2	67814909	67814909	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:67814909delT	ENST00000419809.1	-	0	126																											aagagatttcttttttttttt	0.353													4	2	---	---	---	---					
PCBP1-AS1	400960	broad.mit.edu	37	2	70259626	70259626	+	RNA	DEL	A	A	-	rs79266731		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:70259626delA	ENST00000416395.1	-	0	394				PCBP1-AS1_ENST00000444410.1_RNA|PCBP1-AS1_ENST00000457770.1_RNA|PCBP1-AS1_ENST00000456161.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000425333.1_RNA|PCBP1-AS1_ENST00000599427.1_RNA|PCBP1-AS1_ENST00000435880.2_RNA|PCBP1-AS1_ENST00000434781.1_RNA|PCBP1-AS1_ENST00000421843.1_RNA|PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000429599.2_RNA|PCBP1-AS1_ENST00000420309.1_RNA|PCBP1-AS1_ENST00000419963.1_RNA|PCBP1-AS1_ENST00000422515.1_RNA|PCBP1-AS1_ENST00000418564.1_RNA|PCBP1-AS1_ENST00000449178.1_RNA|PCBP1-AS1_ENST00000425601.1_RNA|PCBP1-AS1_ENST00000418308.1_RNA|PCBP1-AS1_ENST00000415222.1_RNA|PCBP1-AS1_ENST00000421255.1_RNA|PCBP1-AS1_ENST00000415742.1_RNA|PCBP1-AS1_ENST00000411429.1_RNA|PCBP1-AS1_ENST00000601431.1_RNA|PCBP1-AS1_ENST00000432604.1_RNA|PCBP1-AS1_ENST00000599673.1_RNA|PCBP1-AS1_ENST00000458686.1_RNA|PCBP1-AS1_ENST00000413436.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000594376.2_RNA|PCBP1-AS1_ENST00000366234.3_RNA|PCBP1-AS1_ENST00000457076.1_RNA|PCBP1-AS1_ENST00000413069.1_RNA|PCBP1-AS1_ENST00000597318.1_RNA																							tggtctctacaaaaaaaaaaa	0.483													3	4	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	80980987	80980987	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:80980987delA	ENST00000450290.1	-	0	468																											ctcaaaagagaaaaaaaaaaa	0.423													3	3	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	87832829	87832829	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:87832829delT	ENST00000409054.1	+	0	278					NR_015395.1																						ATATTTTGTCTTTAAAAAAAA	0.348													2	4	---	---	---	---					
LOC101928371	101928371	broad.mit.edu	37	2	88846038	88846043	+	RNA	DEL	AACAAC	AACAAC	-	rs72223275		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:88846038_88846043delAACAAC	ENST00000413234.1	+	0	650																											atctcTACAAaacaacaacaacaaca	0.515													3	5	---	---	---	---					
SLC4A10	57282	broad.mit.edu	37	2	162443353	162443354	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:162443353_162443354insA	ENST00000605990.1	+	0	344																											TTGGAAAAGTGAAAAAAGGATT	0.332													2	4	---	---	---	---					
SLC4A10	57282	broad.mit.edu	37	2	162456375	162456375	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:162456375delT	ENST00000605990.1	+	0	344																											aggcatattcttttttttttt	0.363													2	4	---	---	---	---					
AC074363.1	0	broad.mit.edu	37	2	168182598	168182598	+	RNA	DEL	T	T	-	rs34790586		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:168182598delT	ENST00000442316.1	+	0	164																											ccaatatctgttttttttttt	0.358													6	2	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182167451	182167452	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:182167451_182167452insA	ENST00000435411.1	+	0	358																											AATATATATTTAAAAAACAAAT	0.282													2	4	---	---	---	---					
AC079613.1	0	broad.mit.edu	37	2	189544506	189544507	+	RNA	INS	-	-	TG	rs146953782	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:189544506_189544507insTG	ENST00000431708.1	-	0	218																											CCTAACGACACtgtgtgtgtgt	0.376													4	3	---	---	---	---					
LOC101927619	101927619	broad.mit.edu	37	2	199166256	199166257	+	RNA	DEL	TC	TC	-	rs142093168		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:199166256_199166257delTC	ENST00000456248.1	-	0	357_358																											TTCCTGAACATCTGTCTTGTGA	0.401													5	1	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208233145	208233146	+	RNA	DEL	AT	AT	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:208233145_208233146delAT	ENST00000418850.1	-	0	400				AC007879.5_ENST00000412387.1_RNA																							TGCCTGAAACATGTGGCTTTTT	0.495													2	4	---	---	---	---					
AC114765.1	0	broad.mit.edu	37	2	221040353	221040354	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:221040353_221040354insA	ENST00000432993.1	+	0	306				AC114765.2_ENST00000438633.1_lincRNA																							ctcatctctacaaaaaatttga	0.495													2	4	---	---	---	---					
AC009410.1	0	broad.mit.edu	37	2	229448725	229448726	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr2:229448725_229448726insC	ENST00000432481.2	-	0	144																											CCTCTAGTCCTCCCCCCGACCT	0.540													2	4	---	---	---	---					
AC026167.1	0	broad.mit.edu	37	3	6348223	6348224	+	RNA	DEL	AA	AA	-	rs139632007		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:6348223_6348224delAA	ENST00000435651.1	+	0	95																											aaccagtaataaaaaaaaaaaa	0.361													2	4	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8296806	8296806	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:8296806delA	ENST00000420095.1	-	0	571				LMCD1-AS1_ENST00000452802.1_RNA|LMCD1-AS1_ENST00000446281.1_RNA	NR_033378.1																						cacattctctaaaaaaatgta	0.522													2	4	---	---	---	---					
EAF1-AS1	100873956	broad.mit.edu	37	3	15484873	15484874	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:15484873_15484874insA	ENST00000593876.1	-	0	110_111				EAF1-AS1_ENST00000599742.1_RNA|EAF1-AS1_ENST00000594820.1_RNA																							caaaccatcccaaaactcaatg	0.426													2	4	---	---	---	---					
RP11-457K10.1	0	broad.mit.edu	37	3	109454941	109454942	+	RNA	INS	-	-	T	rs139433721	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:109454941_109454942insT	ENST00000485384.1	+	0	29																											agccaaatcagtaatgttggca	0.292													4	2	---	---	---	---					
ZIC1	7545	broad.mit.edu	37	3	147128838	147128839	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:147128838_147128839delCG	ENST00000282928.4	+	1	1668_1669	c.939_940delCG	c.(937-942)ttcgfs	p.FA313fs		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	313					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						GCAAGGTCTTCGCGCGCTCCGA	0.569													86	137	---	---	---	---					
RP11-379F4.4	0	broad.mit.edu	37	3	158480139	158480139	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:158480139delT	ENST00000468242.1	+	0	431				RP11-379F4.4_ENST00000465477.1_RNA																							tgaccaataattttttttttt	0.383													3	4	---	---	---	---					
LINC01192	647107	broad.mit.edu	37	3	162940238	162940239	+	RNA	INS	-	-	T	rs71154467		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:162940238_162940239insT	ENST00000490357.1	+	0	338				CT64_ENST00000470546.1_lincRNA																							ttttgtggtacttttttttttt	0.317													6	0	---	---	---	---					
RP11-644C3.1	0	broad.mit.edu	37	3	176515058	176515059	+	RNA	DEL	AC	AC	-	rs72468363		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:176515058_176515059delAC	ENST00000428516.1	-	0	198																											ACACAAACAGACACACACACAC	0.366													4	9	---	---	---	---					
LOC102724550	102724550	broad.mit.edu	37	3	177611079	177611079	+	RNA	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:177611079delG	ENST00000436078.1	+	0	132																											ttctccttttgctgtgcttct	0.338													2	4	---	---	---	---					
RP11-132N15.3	0	broad.mit.edu	37	3	187687405	187687405	+	RNA	DEL	G	G	-	rs142595260		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:187687405delG	ENST00000446091.1	-	0	82																											gtcctaccaagggtagatgac	0.468													4	3	---	---	---	---					
LPP	4026	broad.mit.edu	37	3	188327341	188327343	+	In_Frame_Del	DEL	CTA	CTA	-	rs150933081		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr3:188327341_188327343delCTA	ENST00000312675.4	+	6	1068_1070	c.822_824delCTA	c.(820-825)gcc>gc	p.AY274del	LPP_ENST00000543006.1_In_Frame_Del_p.AY274del|LPP_ENST00000448637.1_In_Frame_Del_p.AY274del|LPP_ENST00000471917.1_3'UTR	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	274	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TGGATTATGCCTACATTCCACCA	0.567			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								9	195	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14875294	14875294	+	RNA	DEL	G	G	-	rs57857477		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:14875294delG	ENST00000505089.1	-	0	111																											AGAAAGAAATGGCTGGATATT	0.458													3	4	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19614730	19614730	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:19614730delA	ENST00000511431.1	+	0	288																											ATAGTCCTTCAAAATTTAGGC	0.438													2	4	---	---	---	---					
COX7B2	170712	broad.mit.edu	37	4	46737019	46737040	+	Frame_Shift_Del	DEL	TCTATTCCAATCTGAGTGGCTG	TCTATTCCAATCTGAGTGGCTG	-	rs140822119	byFrequency	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:46737019_46737040delTCTATTCCAATCTGAGTGGCTG	ENST00000396533.1	-	4	420_441	c.170_191delCAGCCACTCAGATTGGAATAGA	c.(169-192)aafs	p.TATQIGIE57fs	COX7B2_ENST00000355591.3_Frame_Shift_Del_p.TATQIGIE57fs|COX7B2_ENST00000543208.1_Frame_Shift_Del_p.TATQIGIE56fs|COX7B2_ENST00000302930.5_Frame_Shift_Del_p.TATQIGIE57fs			Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2	57						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			large_intestine(1)|lung(4)	5						TAGGTTCCATTCTATTCCAATCTGAGTGGCTGTAAACACCCA	0.405													7	102	---	---	---	---					
LOC101928851	101928851	broad.mit.edu	37	4	58329893	58329893	+	RNA	DEL	A	A	-	rs72383448		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:58329893delA	ENST00000510956.1	+	0	544																											AGTTTTAATGAAAAAAAAAAA	0.284													4	2	---	---	---	---					
FAM13A-AS1	285512	broad.mit.edu	37	4	89633692	89633693	+	RNA	INS	-	-	T	rs145824356		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:89633692_89633693insT	ENST00000500765.1	+	0	640					NR_002806.2																						tctaaatcacattttttttttt	0.272													3	5	---	---	---	---					
RP11-145G20.1	0	broad.mit.edu	37	4	97261078	97261078	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:97261078delT	ENST00000513393.1	+	0	94																											catatgttcatggcagcacta	0.353													6	3	---	---	---	---					
RP11-556I14.1	0	broad.mit.edu	37	4	105904797	105904798	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:105904797_105904798insA	ENST00000506386.1	+	0	71																											taagcaaaaagaacaaaattaa	0.356													2	4	---	---	---	---					
RP13-578N3.3	0	broad.mit.edu	37	4	144709864	144709865	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:144709864_144709865insT	ENST00000499587.2	+	0	178																											GTCCTCAGTTGTTTTCCCCTTT	0.381													2	4	---	---	---	---					
RP13-487K5.1	0	broad.mit.edu	37	4	156437008	156437009	+	RNA	INS	-	-	T	rs113653735		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:156437008_156437009insT	ENST00000508265.1	+	0	130_131																											GTGTTTTGTGGTTTTTTTTCCA	0.376													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190830344	190830344	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr4:190830344delA	ENST00000511785.1	-	0	231																											atatcacattattaattttta	0.279													5	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3446147	3446148	+	RNA	INS	-	-	GGT			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:3446147_3446148insGGT	ENST00000505443.1	-	0	459					NR_033898.1																						atggtggtgacggtgatggtga	0.520													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3517174	3517175	+	RNA	DEL	GG	GG	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:3517174_3517175delGG	ENST00000505443.1	-	0	459					NR_033898.1																						CTGCTACCTAGGGAGAGGTCAG	0.485													4	3	---	---	---	---					
LOC101928858	101928858	broad.mit.edu	37	5	66765309	66765309	+	RNA	DEL	T	T	-	rs75591439		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:66765309delT	ENST00000508512.1	-	0	63																		p.0?(1)									aaagtgcccctatgttatccc	0.333													2	4	---	---	---	---					
LINC01340	102546227	broad.mit.edu	37	5	96992709	96992712	+	RNA	DEL	ACAC	ACAC	-	rs147012478		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:96992709_96992712delACAC	ENST00000504012.1	+	0	159																											cacccccccaacacacacacacac	0.520													2	4	---	---	---	---					
LOC285638	285638	broad.mit.edu	37	5	108658592	108658593	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:108658592_108658593insC	ENST00000512693.1	-	0	3374																											CCCTGCAGCAGCCCCCCCGACT	0.599													2	4	---	---	---	---					
CTD-2287O16.4	0	broad.mit.edu	37	5	115414110	115414111	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:115414110_115414111insA	ENST00000605999.1	-	0	156_157																											TGGGAAAGAGGAAAACTGGGGC	0.495													2	4	---	---	---	---					
LINC01170	103724389	broad.mit.edu	37	5	123679713	123679713	+	RNA	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:123679713delG	ENST00000519703.1	-	0	171																											AGAAAGGGCAGGTAAATAGAT	0.338													2	4	---	---	---	---					
RP11-114J13.1	0	broad.mit.edu	37	5	125487952	125487953	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:125487952_125487953insT	ENST00000450613.2	-	0	71																											aaaatcctctctttttttgttc	0.371													2	4	---	---	---	---					
LINC01183	728586	broad.mit.edu	37	5	127090215	127090216	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr5:127090215_127090216insC	ENST00000514853.2	+	0	278																											aTTGCAGTATGCCCCCCCACCC	0.421													3	5	---	---	---	---					
LINC00518	221718	broad.mit.edu	37	6	10430699	10430701	+	RNA	DEL	TTT	TTT	-	rs79230388		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:10430699_10430701delTTT	ENST00000496285.1	-	0	489					NR_027793.1																						CTCTGACTAGttttttttttttt	0.448													2	4	---	---	---	---					
RP1-8B1.4	0	broad.mit.edu	37	6	46076058	46076058	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:46076058delA	ENST00000444038.2	-	0	88				RP1-8B1.4_ENST00000437249.2_RNA																							tataaactgcaaaaaaaaagg	0.323													2	4	---	---	---	---					
LOC101927189	101927189	broad.mit.edu	37	6	53802796	53802797	+	RNA	INS	-	-	T	rs6909420	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:53802796_53802797insT	ENST00000431554.2	+	0	232																											AAGAAAAACTGTTTTTTTTTTC	0.381													2	4	---	---	---	---					
RP1-240B8.3	0	broad.mit.edu	37	6	62357020	62357020	+	RNA	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:62357020delG	ENST00000511849.2	-	0	404																											cactgtgcctggccCATATGG	0.438													4	2	---	---	---	---					
LOC101928516	101928516	broad.mit.edu	37	6	75338420	75338420	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:75338420delA	ENST00000435946.1	+	0	193				RP11-554D15.3_ENST00000432484.2_lincRNA																							caataaagataaaaaaggaca	0.363													2	4	---	---	---	---					
RP1-90L14.1	0	broad.mit.edu	37	6	85151497	85151498	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:85151497_85151498insT	ENST00000454981.1	-	0	289																											TTTGACCTTCATTTTTTTTTTT	0.421													2	4	---	---	---	---					
Y_RNA	0	broad.mit.edu	37	6	130895215	130895215	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:130895215delT	ENST00000365568.1	-	0	42																											aagtaactggttaagatcaat	0.373													2	4	---	---	---	---					
LOC102723724	102723724	broad.mit.edu	37	6	141169894	141169895	+	RNA	INS	-	-	AA	rs11286863		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:141169894_141169895insAA	ENST00000455011.1	-	0	106																											caagaagaagcaaaaaaaaaaa	0.356													2	4	---	---	---	---					
RP1-292B18.4	0	broad.mit.edu	37	6	151501170	151501170	+	RNA	DEL	T	T	-	rs66938768		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:151501170delT	ENST00000415477.1	-	0	66																											CTCTCTCTCGttttttttttt	0.458													2	4	---	---	---	---					
OSTCP1	202459	broad.mit.edu	37	6	159268489	159268489	+	RNA	DEL	T	T	-	rs34650186		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:159268489delT	ENST00000522287.1	-	0	172					NR_028496.1																						ctttctttccttttttttttc	0.512													3	5	---	---	---	---					
LOC101929297	101929297	broad.mit.edu	37	6	166653410	166653411	+	RNA	INS	-	-	T	rs72110306	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr6:166653410_166653411insT	ENST00000444219.1	+	0	72																											CCTACCATTTCTTTTTTTTTAG	0.287													2	4	---	---	---	---					
FOXK1	221937	broad.mit.edu	37	7	4780475	4780476	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:4780475_4780476insT	ENST00000328914.4	+	2	567_568	c.567_568insT	c.(565-570)actccgfs	p.P190fs	FOXK1_ENST00000446823.1_Frame_Shift_Ins_p.P27fs	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	190					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCAGGTGTACCTTCCGGTTTCC	0.589													33	275	---	---	---	---					
RSPH10B2	728194	broad.mit.edu	37	7	6825592	6825595	+	Frame_Shift_Del	DEL	ATAA	ATAA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:6825592_6825595delATAA	ENST00000403107.1	+	15	2158_2161	c.1771_1774delATAA	c.(1771-1776)atfs	p.IN591fs	RSPH10B2_ENST00000463354.2_3'UTR|RSPH10B2_ENST00000297186.3_Frame_Shift_Del_p.IN591fs|RSPH10B2_ENST00000433859.2_Frame_Shift_Del_p.IN591fs|RSPH10B2_ENST00000359718.3_3'UTR|RSPH10B2_ENST00000404077.1_Frame_Shift_Del_p.IN591fs					radial spoke head 10 homolog B2 (Chlamydomonas)											breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|skin(2)	15						CTTTAAAATGATAAATAAAGAATT	0.289													4	7	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11391087	11391088	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:11391087_11391088insT	ENST00000421121.1	+	0	113				AC004538.3_ENST00000445839.1_RNA|AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000599875.1_RNA																							tttcttttttatttttgttttt	0.361													3	3	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11676589	11676614	+	Splice_Site	DEL	CTACAAAAATTATAACACAAAAATTA	CTACAAAAATTATAACACAAAAATTA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:11676589_11676614delCTACAAAAATTATAACACAAAAATTA	ENST00000423059.3	-	2	442		c.e2-1		THSD7A_ENST00000480061.1_Splice_Site	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCCCATGGACCTACAAAAATTATAACACAAAAATTAGCAGTGCTAC	0.456										HNSCC(18;0.044)			7	86	---	---	---	---					
LINC01162	104355138	broad.mit.edu	37	7	21018363	21018364	+	RNA	DEL	CA	CA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:21018363_21018364delCA	ENST00000447262.2	+	0	151																											tgtgcgcacgcacacacacaca	0.490													4	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34447805	34447805	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:34447805delT	ENST00000419766.1	-	0	404					NR_033664.1|NR_033665.1																						ccccatcatgttttaacctgc	0.358													2	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34585623	34585624	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:34585623_34585624insT	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						acttttgattgtttttttcatc	0.302													2	4	---	---	---	---					
RP4-724E13.2	0	broad.mit.edu	37	7	51013497	51013497	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:51013497delA	ENST00000420449.1	+	0	24																											aaaacaaaacaaaaaaacaag	0.448													2	4	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53748021	53748021	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:53748021delT	ENST00000380970.2	-	0	1544					NR_038371.1																						atcttctcccttttttttttc	0.308													2	4	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53807054	53807055	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:53807054_53807055insA	ENST00000380970.2	-	0	1381					NR_038371.1																						tcgagatctacagggagattac	0.371													4	5	---	---	---	---					
RP11-368M16.3	0	broad.mit.edu	37	7	57698805	57698817	+	RNA	DEL	GACTTATACCCAG	GACTTATACCCAG	-	rs113395817		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:57698805_57698817delGACTTATACCCAG	ENST00000605139.1	-	0	416																											GGAACTTTGAGACTTATACCCAGGGCTGAGATG	0.484													7	7	---	---	---	---					
RP11-340I6.3	0	broad.mit.edu	37	7	62874011	62874012	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:62874011_62874012insA	ENST00000424036.1	+	0	290																											CTATTTTGTTCAAAAAATCATT	0.366													2	4	---	---	---	---					
GTF2IRD1P1	729156	broad.mit.edu	37	7	66304731	66304731	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:66304731delT	ENST00000457166.1	-	0	189					NR_003934.1																						TTTCTTTCCCttttttttttt	0.512													4	7	---	---	---	---					
MTERF1	7978	broad.mit.edu	37	7	91417431	91417431	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:91417431delT	ENST00000454222.1	-	0	159																											ATGCTGTCGGTTCCATGGAAA	0.383													2	4	---	---	---	---					
LOC101927497	101927497	broad.mit.edu	37	7	92516984	92516985	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:92516984_92516985insC	ENST00000419668.1	+	0	189				AC002454.1_ENST00000424523.1_RNA|AC002454.1_ENST00000435695.1_RNA|AC002454.1_ENST00000452050.1_RNA																							ttgaatattgtcccccagtttc	0.411													2	4	---	---	---	---					
AC073071.1	0	broad.mit.edu	37	7	109195076	109195079	+	RNA	DEL	AAAC	AAAC	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:109195076_109195079delAAAC	ENST00000412410.1	-	0	299																											accaagagcaaaacaaacaaacaa	0.343													2	4	---	---	---	---					
RP11-744I24.2	0	broad.mit.edu	37	7	141249837	141249838	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr7:141249837_141249838insT	ENST00000567503.1	-	0	161				RP11-744I24.2_ENST00000566357.1_RNA																							CCGCCCCGGCCTTTTTTTTTTG	0.480													2	4	---	---	---	---					
CTD-2281E23.2	0	broad.mit.edu	37	8	1205486	1205487	+	RNA	INS	-	-	TT	rs147860078	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:1205486_1205487insTT	ENST00000522989.1	+	0	200																											GTGTGTGTGTGTCCTCATCTTG	0.594													5	1	---	---	---	---					
LOC157273	157273	broad.mit.edu	37	8	9183102	9183103	+	RNA	INS	-	-	AGAAGAAAGGG	rs33912870	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:9183102_9183103insAGAAGAAAGGG	ENST00000520390.1	+	0	363					NR_040039.1																						AGGAAAGAGGAAAGGGAACAGG	0.545													3	6	---	---	---	---					
RP11-546K22.1	0	broad.mit.edu	37	8	52874769	52874769	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:52874769delA	ENST00000521188.1	+	0	113																											ATTagaaaagaaaaaaagttt	0.413													2	4	---	---	---	---					
LINC01181	379034	broad.mit.edu	37	8	104141642	104141643	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:104141642_104141643insT	ENST00000503718.2	+	0	182																											tatagttcccatttttttccaa	0.342													2	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	110051500	110051501	+	RNA	INS	-	-	TGTGTG	rs112270390	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:110051500_110051501insTGTGTG	ENST00000522244.1	-	0	264																											TCACCCAATTATGTGTGTGTGT	0.381													6	4	---	---	---	---					
RP11-369K17.1	0	broad.mit.edu	37	8	121972003	121972004	+	RNA	INS	-	-	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:121972003_121972004insG	ENST00000517739.1	+	0	95																											TGTGTGTGGTTGGGGGCAGTGG	0.455													2	4	---	---	---	---					
RP11-369K17.1	0	broad.mit.edu	37	8	121986122	121986123	+	RNA	DEL	GT	GT	-	rs71571684		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:121986122_121986123delGT	ENST00000517739.1	+	0	95																											AACCAACCAGgtgtgtgtgtgt	0.396													2	4	---	---	---	---					
RP11-513H8.1	0	broad.mit.edu	37	8	135247131	135247132	+	RNA	INS	-	-	T	rs142967406	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:135247131_135247132insT	ENST00000523317.1	-	0	84																											cattccaccccggcctctcccg	0.485													10	1	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138867137	138867138	+	RNA	INS	-	-	TG	rs74344213		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:138867137_138867138insTG	ENST00000518973.1	-	0	514				RP11-238K6.2_ENST00000519652.1_lincRNA																							CCTCGGtttttttttttttttt	0.391													3	3	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138877081	138877084	+	RNA	DEL	TTTG	TTTG	-	rs34554633		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:138877081_138877084delTTTG	ENST00000518973.1	-	0	514				RP11-238K6.2_ENST00000519652.1_lincRNA																							AAGTGTCTTTtttgtttgtttgtt	0.382													5	1	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	139038181	139038181	+	RNA	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr8:139038181delC	ENST00000518973.1	-	0	514																											ACTCAGGTTACCAACTCCTCT	0.498													2	4	---	---	---	---					
GLIS3	169792	broad.mit.edu	37	9	4117825	4117828	+	Frame_Shift_Del	DEL	GCGG	GCGG	-	rs147451000	byFrequency	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:4117825_4117828delGCGG	ENST00000324333.10	-	3	1378_1381	c.1185_1188delCCGC	c.(1183-1188)gcfs	p.AR395fs	GLIS3_ENST00000381971.3_Frame_Shift_Del_p.AR550fs	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	395					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding	p.R396H(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCAGTTTATAGCGGGCGTTGAAGG	0.574													21	181	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21971024	21971024	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:21971024delG	ENST00000579755.1	-	2	669	c.377delC	c.(376-378)cgfs	p.P126fs	CDKN2A_ENST00000304494.5_Frame_Shift_Del_p.R112fs|CDKN2A_ENST00000579122.1_Frame_Shift_Del_p.R112fs|CDKN2A_ENST00000498628.2_Frame_Shift_Del_p.R61fs|CDKN2A_ENST00000446177.1_Frame_Shift_Del_p.R112fs|CDKN2A_ENST00000479692.2_Frame_Shift_Del_p.R61fs|CDKN2A_ENST00000498124.1_Frame_Shift_Del_p.R112fs|CDKN2A_ENST00000361570.3_Frame_Shift_Del_p.P167fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000578845.2_Frame_Shift_Del_p.R61fs|CDKN2A_ENST00000530628.2_Frame_Shift_Del_p.P126fs|CDKN2A_ENST00000494262.1_Frame_Shift_Del_p.R61fs|CDKN2A_ENST00000497750.1_Frame_Shift_Del_p.R61fs			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0			V -> D (in CMM2; impairs the function).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.R112G(4)|p.H83fs*2(2)|p.0(1)|p.R112S(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.R112fs*32(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		ACGGGCAGACGGCCCCAGGCA	0.736		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	30	---	---	---	---					
UBE2R2-AS1	101929665	broad.mit.edu	37	9	33802685	33802686	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:33802685_33802686insA	ENST00000454429.2	-	0	169																											GGTAAAGTGGTATGATCTTCCA	0.455													6	5	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68398095	68398095	+	RNA	DEL	C	C	-	rs74487823		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:68398095delC	ENST00000417843.2	-	0	2660																											CCATGCTTAGCTTGGGTTTCT	0.353													9	11	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68401527	68401527	+	RNA	DEL	C	C	-	rs111275793	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:68401527delC	ENST00000417843.2	-	0	292																											TAAGCACTTTCTTTCTAGCTG	0.413													3	5	---	---	---	---					
LOC101927502	101927502	broad.mit.edu	37	9	84356033	84356034	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:84356033_84356034insA	ENST00000437181.1	+	0	247																											GATTATTTTGCAAAAAAAGGCA	0.307													2	4	---	---	---	---					
RP11-505C13.1	0	broad.mit.edu	37	9	111016552	111016553	+	RNA	DEL	TA	TA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:111016552_111016553delTA	ENST00000453455.1	-	0	109																											GTATGGGgtgtatatgtgtgtg	0.421													5	4	---	---	---	---					
RP11-202G18.1	0	broad.mit.edu	37	9	113982821	113982822	+	RNA	INS	-	-	AGGG	rs146446287	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr9:113982821_113982822insAGGG	ENST00000426204.1	-	0	370																											ggaaggaaagaaggaaggCCGa	0.416													3	5	---	---	---	---					
ZEB1-AS1	220930	broad.mit.edu	37	10	31593773	31593774	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:31593773_31593774insA	ENST00000605946.1	-	0	177																											CAAGGGAGGACAAAAAAATGTA	0.376													2	4	---	---	---	---					
ZNF518A	9849	broad.mit.edu	37	10	97908197	97908198	+	RNA	INS	-	-	A	rs76332240		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:97908197_97908198insA	ENST00000534948.1	+	0	456							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		aactctgtctcaaaaaaaaaaa	0.406													2	4	---	---	---	---					
RP11-355F22.1	0	broad.mit.edu	37	10	119588578	119588579	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:119588578_119588579insA	ENST00000575236.1	-	0	52																											AAAACAAAACCAAAAACCCATC	0.376													2	4	---	---	---	---					
CASC2	255082	broad.mit.edu	37	10	119866523	119866523	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:119866523delA	ENST00000435944.1	+	0	452				CASC2_ENST00000439517.1_RNA|CASC2_ENST00000454857.1_RNA|CASC2_ENST00000414722.1_RNA	NR_026939.1																						ttaataatccagactccagaa	0.443													2	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125153181	125153182	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr10:125153181_125153182insT	ENST00000448347.1	+	0	586																											TGCTTTCAGTATTTCAAAAACT	0.396													2	4	---	---	---	---					
LSP1	4046	broad.mit.edu	37	11	1902785	1902786	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:1902785_1902786insC	ENST00000406638.2	+	3	1431_1432	c.129_130insC	c.(127-132)gaccccfs	p.DP43fs	LSP1_ENST00000405957.2_Frame_Shift_Ins_p.DP43fs|LSP1_ENST00000485341.1_3'UTR|LSP1_ENST00000381775.1_Frame_Shift_Ins_p.DP233fs|LSP1_ENST00000311604.3_Frame_Shift_Ins_p.DP105fs	NM_001013254.1|NM_001013255.1	NP_001013272.1|NP_001013273.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	105					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity	p.Q46fs*31(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		ACAGCGGAGAGCCCCCCCAGTG	0.703													2	4	---	---	---	---					
RP11-504G3.4	0	broad.mit.edu	37	11	18617151	18617151	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:18617151delT	ENST00000541939.1	-	0	424																											ACAGCAGTTGTTTTTTTTTAA	0.507													2	4	---	---	---	---					
RP11-587D21.4	0	broad.mit.edu	37	11	27843986	27843986	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:27843986delT	ENST00000530663.1	-	0	147																											TGGTTcttccttccttcctct	0.408													2	4	---	---	---	---					
AP000662.4	0	broad.mit.edu	37	11	57409960	57409961	+	RNA	INS	-	-	A	rs72339341		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:57409960_57409961insA	ENST00000530595.1	+	0	297																											gactccatctcaaaaaaaaaaa	0.431													3	2	---	---	---	---					
WTAPP1	100288077	broad.mit.edu	37	11	102623121	102623122	+	RNA	DEL	GT	GT	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:102623121_102623122delGT	ENST00000416164.1	-	0	66																											AGCTACACAGGTGTGTGTGTGT	0.490													2	4	---	---	---	---					
TMPRSS4-AS1	100526771	broad.mit.edu	37	11	117916045	117916046	+	RNA	INS	-	-	CACA	rs57274300		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr11:117916045_117916046insCACA	ENST00000606951.1	-	0	195				TMPRSS4-AS1_ENST00000527695.1_RNA|TMPRSS4-AS1_ENST00000527329.1_RNA	NR_038318.1																						ATacacacatgcacacacacac	0.416													2	4	---	---	---	---					
RP11-405A12.2	0	broad.mit.edu	37	12	20059784	20059785	+	RNA	INS	-	-	T	rs7976007	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:20059784_20059785insT	ENST00000535764.1	+	0	153																											tgtcactaagatataaaaaaaa	0.391													2	4	---	---	---	---					
LOC645485	645485	broad.mit.edu	37	12	30917966	30917966	+	RNA	DEL	A	A	-	rs80159791		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:30917966delA	ENST00000500076.2	+	0	198																											TCTGTGCCAGAAAAAAATTCA	0.333													4	2	---	---	---	---					
RP11-370I10.2	0	broad.mit.edu	37	12	48657011	48657022	+	RNA	DEL	GGCTACCTGGGA	GGCTACCTGGGA	-	rs67650170		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:48657011_48657022delGGCTACCTGGGA	ENST00000547523.1	-	0	269																											ctataatcccggctacctgggaggctgaggca	0.514													2	4	---	---	---	---					
RP11-74M13.4	0	broad.mit.edu	37	12	57235382	57235383	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:57235382_57235383insT	ENST00000557452.1	+	0	720																											agaaaggtttctttttttaaca	0.342													2	4	---	---	---	---					
LOC100507065	100507065	broad.mit.edu	37	12	65955550	65955551	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:65955550_65955551insA	ENST00000546198.1	-	0	391																											AGAATTTTCCCAGGGAGAGATG	0.495													2	4	---	---	---	---					
LGR5	8549	broad.mit.edu	37	12	71918213	71918226	+	Frame_Shift_Del	DEL	CATTCCCAAGGGAG	CATTCCCAAGGGAG	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:71918213_71918226delCATTCCCAAGGGAG	ENST00000266674.5	+	3	623_636	c.312_325delCATTCCCAAGGGAG	c.(310-327)tacafs	p.YIPKGA104fs	LGR5_ENST00000540815.2_Frame_Shift_Del_p.YIPKGA104fs|LGR5_ENST00000536515.1_Frame_Shift_Del_p.YIPKGA104fs			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	104						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CTCTGACATACATTCCCAAGGGAGCATTCACTGG	0.393													7	94	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	75962951	75962951	+	RNA	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:75962951delC	ENST00000552856.1	-	0	549																											TTTCTAGGAACAAAAAAATCA	0.338													2	4	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78516143	78516153	+	Frame_Shift_Del	DEL	AGGCACTCACG	AGGCACTCACG	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:78516143_78516153delAGGCACTCACG	ENST00000397909.2	+	16	4346_4356	c.4173_4183delAGGCACTCACG	c.(4171-4185)acagfs	p.TGTHE1391fs	NAV3_ENST00000266692.7_Intron|NAV3_ENST00000228327.6_Frame_Shift_Del_p.TGTHE1391fs|NAV3_ENST00000536525.2_Frame_Shift_Del_p.TGTHE1391fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1391	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GACTGACCACAGGCACTCACGAGGTCCAGAG	0.545										HNSCC(70;0.22)			14	225	---	---	---	---					
RP11-567C2.1	0	broad.mit.edu	37	12	90502326	90502327	+	RNA	DEL	GA	GA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:90502326_90502327delGA	ENST00000548722.2	+	0	83																											GAAGTTGGGGgagagagagaga	0.386													3	4	---	---	---	---					
LOC101928617	101928617	broad.mit.edu	37	12	92559087	92559088	+	RNA	INS	-	-	T	rs72193862	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:92559087_92559088insT	ENST00000499685.2	+	0	164				RP11-796E2.4_ENST00000501008.2_RNA																							TTTGTTCAATGTTTTTTTTCTG	0.347													3	3	---	---	---	---					
RP11-690J15.1	0	broad.mit.edu	37	12	98569928	98569928	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:98569928delA	ENST00000548344.1	-	0	68																											aaaggaaaggaaaggcataca	0.458													2	4	---	---	---	---					
STAB2	55576	broad.mit.edu	37	12	104109609	104109609	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:104109609delG	ENST00000388887.2	+	43	4758	c.4554delG	c.(4552-4554)ttfs	p.L1518fs		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1518	EGF-like 13.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ACCCGTGTTTGGAGAACCATG	0.507													19	49	---	---	---	---					
FAM101A	144347	broad.mit.edu	37	12	124579716	124579717	+	RNA	INS	-	-	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr12:124579716_124579717insG	ENST00000540762.1	+	0	247																											CAGTTTGAGTTGGGGGCTGGAA	0.460													2	4	---	---	---	---					
BRCA2	675	broad.mit.edu	37	13	32907305	32907314	+	Frame_Shift_Del	DEL	CCAGCCACCA	CCAGCCACCA	-	rs55821741		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:32907305_32907314delCCAGCCACCA	ENST00000544455.1	+	10	1917_1926	c.1690_1699delCCAGCCACCA	c.(1690-1701)ccfs	p.PATT564fs	BRCA2_ENST00000380152.3_Frame_Shift_Del_p.PATT564fs	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	564					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGGAAGCTGGCCAGCCACCACCACACAGAA	0.357			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			10	65	---	---	---	---					
SMIM2-AS1	101929212	broad.mit.edu	37	13	44799499	44799499	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:44799499delA	ENST00000437867.1	+	0	219																											AAACAAAACCAAAAAAAGATG	0.403													2	4	---	---	---	---					
LOC103191607	103191607	broad.mit.edu	37	13	52914114	52914114	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr13:52914114delT	ENST00000603464.1	+	0	83																											atagtaagACttttttttttt	0.428													3	6	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26419312	26419313	+	RNA	INS	-	-	AC	rs34593773		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:26419312_26419313insAC	ENST00000546412.1	-	0	258																											caatactacatacacacacaca	0.386													3	4	---	---	---	---					
RP11-384J4.2	0	broad.mit.edu	37	14	27401666	27401666	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:27401666delT	ENST00000552303.1	+	0	205																											CCTTGGTTCCTTTTTTTTTTT	0.363													2	4	---	---	---	---					
PRKD1	5587	broad.mit.edu	37	14	30646997	30646997	+	RNA	DEL	A	A	-	rs78014443		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:30646997delA	ENST00000508469.2	-	0	398																											ctgtttatttaaaaaaaaaaa	0.363													4	5	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43004880	43004881	+	RNA	INS	-	-	A	rs55908465		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:43004880_43004881insA	ENST00000557251.1	+	0	166																											ctccccctgccaaaaaaaaaaa	0.366													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46635758	46635759	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:46635758_46635759insC	ENST00000556886.1	+	0	58					NR_102701.1																						actggggggtgccccccagtta	0.574													4	9	---	---	---	---					
RP11-2G1.1	0	broad.mit.edu	37	14	48936228	48936228	+	RNA	DEL	C	C	-	rs4630460		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:48936228delC	ENST00000555693.1	-	0	123																											TTAAAATACTCTAAAAGATTT	0.303													4	3	---	---	---	---					
DDHD1	80821	broad.mit.edu	37	14	53619421	53619422	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:53619421_53619422insC	ENST00000357758.3	-	1	578_579	c.395_396insG	c.(394-396)gggfs	p.G132fs	DDHD1_ENST00000395606.1_Frame_Shift_Ins_p.G132fs|DDHD1_ENST00000323669.5_Frame_Shift_Ins_p.G132fs	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	132					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					TCGCGCCGCCGCCCCCCGAGTT	0.743													3	6	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57368585	57368586	+	RNA	INS	-	-	A	rs34778261	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:57368585_57368586insA	ENST00000534909.2	+	0	474				OTX2-AS1_ENST00000554358.1_RNA|OTX2-AS1_ENST00000554725.1_RNA|OTX2-AS1_ENST00000554428.1_RNA	NR_029385.1																						ttttttttttttttgagacaga	0.436													3	3	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66740600	66740601	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr14:66740600_66740601insC	ENST00000556874.1	-	0	643																											tggagaattaaccccccacctc	0.569													2	4	---	---	---	---					
NPAP1	23742	broad.mit.edu	37	15	24923730	24923730	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:24923730delG	ENST00000329468.2	+	1	3190	c.2716delG	c.(2716-2718)ggfs	p.G906fs		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.G906W(2)									GGCCACTGATGGGCAGCAGAA	0.502													26	71	---	---	---	---					
RP11-323I15.5	0	broad.mit.edu	37	15	35447471	35447472	+	RNA	DEL	AA	AA	-	rs10544313		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:35447471_35447472delAA	ENST00000559246.1	-	0	74																											AGAGAACTATAAAAGTTTGAAT	0.322													3	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48232539	48232542	+	RNA	DEL	AGAG	AGAG	-	rs68191778		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:48232539_48232542delAGAG	ENST00000560900.1	+	0	195																											gaaagagaaaAGagagagagagag	0.392													3	5	---	---	---	---					
RP11-1129I3.1	0	broad.mit.edu	37	15	56872066	56872066	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:56872066delA	ENST00000562300.1	-	0	439																											catccccccgaaaaaaaaaag	0.413													2	4	---	---	---	---					
CGNL1	84952	broad.mit.edu	37	15	57730396	57730399	+	Frame_Shift_Del	DEL	ACAT	ACAT	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:57730396_57730399delACAT	ENST00000281282.5	+	2	277_280	c.199_202delACAT	c.(199-204)cgfs	p.TS67fs		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	67	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CCTAGCAGGCACATCGTTTTCTGA	0.490													14	101	---	---	---	---					
RP11-499F3.2	0	broad.mit.edu	37	15	82049580	82049582	+	RNA	DEL	TAT	TAT	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:82049580_82049582delTAT	ENST00000560054.1	-	0	201																											atgaaatgagtattattattatt	0.355													2	4	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84075398	84075398	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:84075398delA	ENST00000565495.1	+	0	264																											AACacattataatggacatcc	0.453													2	4	---	---	---	---					
CSPG4P5	114817	broad.mit.edu	37	15	84957462	84957472	+	RNA	DEL	GTGGCATCTGT	GTGGCATCTGT	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:84957462_84957472delGTGGCATCTGT	ENST00000558801.1	-	0	7257_7267																											CACTTGTAGGGTGGCATCTGTGTGCACTGGC	0.578													4	4	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88071088	88071088	+	RNA	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:88071088delC	ENST00000560439.1	-	0	157																											ggccaaggatccaggaagtgc	0.433													2	4	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92774260	92774261	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr15:92774260_92774261insA	ENST00000561674.1	-	0	185																											GTAGATATGTCAAAAAAATAAA	0.312													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18130977	18130978	+	RNA	INS	-	-	GAT	rs76014085	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:18130977_18130978insGAT	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							atgaggatgaggatgatgatga	0.421													5	2	---	---	---	---					
SNX29P2	440352	broad.mit.edu	37	16	29372347	29372348	+	RNA	INS	-	-	T			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:29372347_29372348insT	ENST00000398878.3	+	0	1186				SNX29P2_ENST00000507381.1_RNA																							ATGGGAGGttgttttttttttt	0.475													3	2	---	---	---	---					
PRR14	78994	broad.mit.edu	37	16	30665950	30665950	+	Splice_Site	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:30665950delC	ENST00000542965.2	+	7	1115	c.658_splice	c.e7-1	p.A220_splice	PRR14_ENST00000300835.4_Splice_Site_p.A220_splice			Q9BWN1	PRR14_HUMAN	proline rich 14	220	Pro-rich.									breast(3)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	18			Colorectal(24;0.103)			CTTTCCTCAGCCCCAGATCCT	0.622													7	9	---	---	---	---					
VPS9D1	9605	broad.mit.edu	37	16	89775655	89775656	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr16:89775655_89775656insG	ENST00000561976.1	-	11	1743_1744	c.1366_1367insC	c.(1366-1368)gaafs	p.E456fs	VPS9D1_ENST00000389386.3_Frame_Shift_Ins_p.E526fs					VPS9 domain containing 1																		CAGCTTCTTCTGGGGGCAGCTC	0.649													2	4	---	---	---	---					
RP11-64J4.2	0	broad.mit.edu	37	17	3217797	3217798	+	RNA	DEL	AT	AT	-	rs77453636		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:3217797_3217798delAT	ENST00000573491.1	-	0	359																											TGATGTAAACATGTGTATGGGC	0.406													3	5	---	---	---	---					
CCT6B	10693	broad.mit.edu	37	17	33266325	33266327	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:33266325_33266327delCAA	ENST00000314144.5	-	10	1203_1205	c.1088_1090delTTG	c.(1087-1092)aag>a	p.IE363del	CCT6B_ENST00000436961.3_In_Frame_Del_p.IE318del|CCT6B_ENST00000421975.3_In_Frame_Del_p.IE326del	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	363					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				ACACACTCCTCAATAAAAGTGAA	0.345													7	63	---	---	---	---					
RP11-445F12.1	0	broad.mit.edu	37	17	35277604	35277604	+	RNA	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:35277604delG	ENST00000532387.2	-	0	95				RP11-445F12.1_ENST00000529264.1_RNA|RP11-445F12.1_ENST00000528383.1_RNA																							TCCAGGGGGAGGGCTGTGTTT	0.612													2	4	---	---	---	---					
YWHAEP7	284100	broad.mit.edu	37	17	36202967	36202968	+	RNA	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:36202967_36202968insC	ENST00000590732.1	-	0	2059_2060					NR_024178.1																						aggatccacggcccccAGCCTG	0.624													2	4	---	---	---	---					
RP11-429O1.1	0	broad.mit.edu	37	17	50470167	50470167	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr17:50470167delT	ENST00000572848.1	+	0	76																											AAAGGGGAGGTTTTCTCATTT	0.299													3	3	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2117819	2117821	+	RNA	DEL	TTC	TTC	-	rs71365148		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:2117819_2117821delTTC	ENST00000579097.1	-	0	310																											agggcccaagttcttcttccttt	0.414													3	3	---	---	---	---					
RPL6P27	645387	broad.mit.edu	37	18	6462715	6462715	+	RNA	DEL	C	C	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:6462715delC	ENST00000583065.1	-	0	183																											CCGTTCTTGTCACCACCAACT	0.463													12	72	---	---	---	---					
C18orf61	497259	broad.mit.edu	37	18	12213237	12213238	+	RNA	INS	-	-	TTT	rs59926954	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:12213237_12213238insTTT	ENST00000586882.1	+	0	125					NR_049896.1																						TAGGCAAACAATTTTTTTTTGG	0.302													2	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39897967	39897968	+	RNA	INS	-	-	A	rs58741959		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:39897967_39897968insA	ENST00000593234.1	+	0	493					NR_046456.1																						gcccacaacccaaaaaacagag	0.322													2	4	---	---	---	---					
LINC01478	101927921	broad.mit.edu	37	18	42030718	42030718	+	RNA	DEL	T	T	-	rs34951283		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:42030718delT	ENST00000587877.1	-	0	386																											TTCTTCGTCCTTTTTTTTTTT	0.363													9	1	---	---	---	---					
EPG5	57724	broad.mit.edu	37	18	43505741	43505744	+	Frame_Shift_Del	DEL	ACAC	ACAC	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:43505741_43505744delACAC	ENST00000282041.5	-	14	2712_2715	c.2678_2681delGTGT	c.(2677-2682)ttfs	p.CV893fs		NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	893					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TTCAAGAATAACACAGGCCAGTTT	0.426													7	120	---	---	---	---					
LOC101927273	101927273	broad.mit.edu	37	18	53567476	53567476	+	RNA	DEL	T	T	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:53567476delT	ENST00000563553.1	-	0	38				CTD-2008L17.1_ENST00000589440.1_lincRNA																							TTTGCCCTTCTTTTTTTTTCC	0.328													2	4	---	---	---	---					
RP11-325K19.1	0	broad.mit.edu	37	18	58452688	58452691	+	RNA	DEL	GTGA	GTGA	-	rs67192527		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:58452688_58452691delGTGA	ENST00000591869.1	-	0	128																											tcttatgatcgtgagtgagttctt	0.456													5	3	---	---	---	---					
RP11-879F14.2	0	broad.mit.edu	37	18	59268271	59268272	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:59268271_59268272insA	ENST00000587754.1	-	0	368				RP11-879F14.1_ENST00000590968.1_lincRNA																							Atgcataaaagaaaaaacaagt	0.312													2	4	---	---	---	---					
ZADH2	284273	broad.mit.edu	37	18	72913517	72913517	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:72913517delA	ENST00000322342.3	-	2	1277	c.988delT	c.(988-990)gtfs	p.C330fs	ZADH2_ENST00000537114.2_Frame_Shift_Del_p.C207fs	NM_175907.4	NP_787103.1	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain containing 2	330						peroxisome	oxidoreductase activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(8)|skin(1)	15		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TCCACCTCACAAACCAGGTCT	0.498													20	45	---	---	---	---					
RP11-176N18.2	0	broad.mit.edu	37	18	75237466	75237467	+	RNA	INS	-	-	AAAC	rs79996296	by1000genomes	TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr18:75237466_75237467insAAAC	ENST00000583629.1	+	0	497																											agctgtGAAATAAACAAAAGAC	0.401													2	4	---	---	---	---					
NOTCH3	4854	broad.mit.edu	37	19	15276860	15276861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:15276860_15276861insC	ENST00000263388.2	-	30	5479_5480	c.5404_5405insG	c.(5404-5406)tctfs	p.S1802fs		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1802					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGGCTCCAGAGCCCCCCCACAG	0.569													9	78	---	---	---	---					
CTC-513N18.6	0	broad.mit.edu	37	19	20619064	20619066	+	RNA	DEL	ACA	ACA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr19:20619064_20619066delACA	ENST00000598131.1	+	0	160																											caatggggccacaacaacaacac	0.483													2	4	---	---	---	---					
PSMF1	9491	broad.mit.edu	37	20	1115871	1115872	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:1115871_1115872insC	ENST00000335877.6	+	4	649_650	c.473_474insC	c.(472-474)tccfs	p.S158fs	PSMF1_ENST00000333082.3_Frame_Shift_Ins_p.S158fs|PSMF1_ENST00000246015.4_Frame_Shift_Ins_p.S158fs|PSMF1_ENST00000484891.1_3'UTR|PSMF1_ENST00000438768.2_Intron|PSMF1_ENST00000381898.4_Frame_Shift_Ins_p.S70fs	NM_006814.3	NP_006805.2	Q92530	PSMF1_HUMAN	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	158	Pro-rich.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)	13						CACCGGGAGTTCCCCCCTGCTA	0.579													7	87	---	---	---	---					
SNAP25-AS1	100131208	broad.mit.edu	37	20	10184382	10184383	+	RNA	DEL	CA	CA	-	rs147738706		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:10184382_10184383delCA	ENST00000603542.1	-	0	518				SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000451151.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000605592.1_RNA|SNAP25-AS1_ENST00000426491.1_RNA	NR_040710.1																						ccctgtgtctcagtttactcat	0.401													5	1	---	---	---	---					
LOC101929486	101929486	broad.mit.edu	37	20	12891312	12891312	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:12891312delA	ENST00000456265.1	-	0	1279																											ccctcattgcaatgaatcagc	0.443													2	4	---	---	---	---					
NCOR1P1	149934	broad.mit.edu	37	20	26093692	26093692	+	RNA	DEL	C	C	-	rs112856804		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:26093692delC	ENST00000478176.1	-	0	150					NR_003678.1																						aaaatcaacacccaatcatga	0.378													2	4	---	---	---	---					
MIR646HG	284757	broad.mit.edu	37	20	58864010	58864011	+	RNA	DEL	GA	GA	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr20:58864010_58864011delGA	ENST00000432910.1	+	0	332					NR_046099.1																						atgcaggagtgagagagagaga	0.495													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11041957	11041963	+	RNA	DEL	AGTTTTG	AGTTTTG	-	rs60976621		TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr21:11041957_11041963delAGTTTTG	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATTTCATATAGTTTTGAGTTTTGAAA	0.309													4	7	---	---	---	---					
TRPM2	7226	broad.mit.edu	37	21	45810823	45810823	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr21:45810823delG	ENST00000397928.1	+	10	1800	c.1355delG	c.(1354-1356)tgfs	p.W452fs	TRPM2_ENST00000300482.5_Frame_Shift_Del_p.W452fs|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000397932.2_Frame_Shift_Del_p.W452fs|TRPM2_ENST00000300481.9_Frame_Shift_Del_p.W452fs	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	452						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CACGAGAACTGGGACCACCAG	0.552													12	48	---	---	---	---					
AP000525.9	0	broad.mit.edu	37	22	16148024	16148025	+	RNA	INS	-	-	A			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chr22:16148024_16148025insA	ENST00000447898.1	-	0	4089_4090																											CTTTAATTGCCAGAAGTAAAAG	0.277													2	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22708709	22708709	+	RNA	DEL	A	A	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:22708709delA	ENST00000455399.1	-	0	178																											GATTAAGACTAAAGTGCCTCC	0.408													2	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22968570	22968570	+	RNA	DEL	G	G	-			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:22968570delG	ENST00000455399.1	-	0	82																											acagcacactgggagctggaa	0.468													2	4	---	---	---	---					
PLXNA3	55558	broad.mit.edu	37	X	153688564	153688565	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z023-01A-01W-0746-08	TCGA-17-Z023-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd72330a-463f-471b-9eba-2f188524e74c	5b2bc510-42db-4afa-bce0-c0aee8ef9c00	g.chrX:153688564_153688565insG	ENST00000369682.3	+	2	216_217	c.41_42insG	c.(40-42)gggfs	p.G14fs		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	14					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity	p.A17fs*39(1)		breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTCCTTGCCGTGGGGGGGGCCC	0.683													5	9	---	---	---	---					
