Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GALNT16	57452	broad.mit.edu	37	14	69805381	69805381	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:69805381G>T	ENST00000337827.4	+	10	1308	c.981G>T	c.(979-981)agG>agT	p.R327S	GALNT16_ENST00000448469.3_Missense_Mutation_p.R327S|GALNT16_ENST00000553669.1_Missense_Mutation_p.R327S	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		TCTCCTTCAGGGTGTGGATGT	0.597000													22	56					3.6726e-16	5.88421e-16	0.021523	1	0
COL3A1	1281	broad.mit.edu	37	2	189856414	189856414	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:189856414G>T	ENST00000304636.3	+	13	1087	c.917G>T	c.(916-918)gGt>gTt	p.G306V	COL3A1_ENST00000317840.5_Missense_Mutation_p.G306V	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	306	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.A304_G309delAPGERG(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGGGCTCCTGGTGAGCGAGGA	0.458000													16	43					2.89027e-11	4.25781e-11	0.014323	1	0
ITGA2	3673	broad.mit.edu	37	5	52340915	52340915	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:52340915G>C	ENST00000296585.5	+	4	523	c.380G>C	c.(379-381)gGt>gCt	p.G127A		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	127					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GGAACTGGAGGTTTTCTCGTG	0.413000													10	30					0	0	0.010729	0	0
NCAM2	4685	broad.mit.edu	37	21	22804571	22804571	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:22804571T>G	ENST00000400546.1	+	12	1873	c.1624T>G	c.(1624-1626)Tgg>Ggg	p.W542G	NCAM2_ENST00000284894.7_Missense_Mutation_p.W400G	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	542	Fibronectin type-III 1.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTCAGAAATCTGGAAAATTGT	0.428000													15	32					0	0	0.004990	0	0
HTR1A	3350	broad.mit.edu	37	5	63256623	63256623	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:63256623G>T	ENST00000323865.3	-	1	1157	c.924C>A	c.(922-924)ccC>ccA	p.P308P	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	308					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CAGCCTCGCTGGGCAGAGGCA	0.647000													14	15					1.56452e-12	2.37246e-12	0.007413	1	0
ZBBX	79740	broad.mit.edu	37	3	167051743	167051743	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:167051743C>A	ENST00000392766.2	-	10	899	c.559G>T	c.(559-561)Gat>Tat	p.D187Y	ZBBX_ENST00000307529.5_Missense_Mutation_p.D187Y|ZBBX_ENST00000392764.1_Missense_Mutation_p.D158Y|ZBBX_ENST00000392767.2_Missense_Mutation_p.D187Y|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000455345.2_Missense_Mutation_p.D187Y	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	187						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TGGGCAACATCCAATACATTG	0.284000													10	43					9.05144e-12	1.34243e-11	0.016723	1	0
POTEF	728378	broad.mit.edu	37	2	130832525	130832525	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:130832525C>T	ENST00000357462.5	-	15	2613	c.2520G>A	c.(2518-2520)ctG>ctA	p.L840L	POTEF_ENST00000409914.2_Silent_p.L840L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	840	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TGTACAGGGACAGCACAGCCT	0.587000													14	18					0	0	0.014323	0	0
POTEA	340441	broad.mit.edu	37	8	43197382	43197382	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:43197382C>A	ENST00000522175.2	+	0	1135							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A									p.S424*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACATGGCCATCAGAAATAGCG	0.338000													10	34					5.50884e-06	6.68985e-06	0.013537	1	0
MMD2	221938	broad.mit.edu	37	7	4947178	4947178	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:4947178A>T	ENST00000404774.3	-	7	856	c.662T>A	c.(661-663)cTg>cAg	p.L221Q	MMD2_ENST00000406755.1_3'UTR|MMD2_ENST00000401401.3_Missense_Mutation_p.L197Q	NM_001100600.1	NP_001094070.1	Q8IY49	PAQRA_HUMAN	monocyte to macrophage differentiation-associated 2	221						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GACCATGCCCAGGCAGTAGAA	0.592000													10	38					0	0	0.006122	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291484	141291484	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:141291484T>A	ENST00000247452.3	-	3	637	c.290A>T	c.(289-291)cAg>cTg	p.Q97L		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	97	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CAgaggactctgggaaggacc	0.577000										HNSCC(46;0.14)			43	87					0	0	0.014410	0	0
IGSF22	283284	broad.mit.edu	37	11	18737215	18737215	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:18737215T>A	ENST00000513874.1	-	11	1434	c.1295A>T	c.(1294-1296)gAg>gTg	p.E432V	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	432	Ig-like 3.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						GCGACTCCTCTCTTTCACACG	0.522000													28	45					0	0	0.012213	0	0
ZRANB1	54764	broad.mit.edu	37	10	126631393	126631393	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:126631393C>T	ENST00000359653.4	+	1	702	c.331C>T	c.(331-333)Cgt>Tgt	p.R111C	RP11-298J20.4_ENST00000508096.1_RNA	NM_017580.2	NP_060050.2	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	111					positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	23		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		CTTATCCCAACGTAGGACCAG	0.433000													18	41					0	0	0.010504	0	0
TP53	7157	broad.mit.edu	37	17	7577570	7577570	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:7577570C>T	ENST00000420246.2	-	7	843	c.711G>A	c.(709-711)atG>atA	p.M237I	TP53_ENST00000455263.2_Missense_Mutation_p.M237I|TP53_ENST00000269305.4_Missense_Mutation_p.M237I|TP53_ENST00000445888.2_Missense_Mutation_p.M237I|TP53_ENST00000413465.2_Missense_Mutation_p.M237I|TP53_ENST00000359597.4_Missense_Mutation_p.M237I	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	237	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(109)|p.0?(8)|p.?(5)|p.M144I(4)|p.M237_N239delMCN(4)|p.Y236_M237delYM(1)|p.H233fs*6(1)|p.M144_N146delMCN(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.H233_C242del10(1)|p.M237fs*1(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	28					0	0	0.008361	0	0
SOBP	55084	broad.mit.edu	37	6	107956353	107956353	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:107956353G>C	ENST00000317357.5	+	6	2964	c.2305G>C	c.(2305-2307)Gag>Cag	p.E769Q	SOBP_ENST00000494935.1_3'UTR	NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	769							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GAGCGAGCTAGAGTCGGTCAA	0.697000													3	4					0	0	0.004672	0	0
PNPLA4	8228	broad.mit.edu	37	X	7894005	7894005	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:7894005C>A	ENST00000381042.4	-	2	326	c.156G>T	c.(154-156)ctG>ctT	p.L52L	PNPLA4_ENST00000444736.1_Silent_p.L52L|PNPLA4_ENST00000537427.1_Intron	NM_004650.2	NP_004641.1	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	52	Patatin.				lipid catabolic process		triglyceride lipase activity			kidney(1)|large_intestine(3)|lung(2)|prostate(1)	7		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				GTGCTGTTAGCAGAACAGAAG	0.458000											OREG0019651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	13					0.000308642	0.000345207	0.003163	1	0
KIAA0754	643314	broad.mit.edu	37	1	39877491	39877491	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:39877491A>T	ENST00000530275.1	+	1	1341	c.1146A>T	c.(1144-1146)gaA>gaT	p.E382D	MACF1_ENST00000361689.2_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000567887.1_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	382										central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TAGAAAAGGAACAGCATTTAG	0.403000													5	50					0	0	0.014758	0	0
KCNS3	3790	broad.mit.edu	37	2	18112663	18112663	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:18112663G>T	ENST00000403915.1	+	3	839	c.388G>T	c.(388-390)Gag>Tag	p.E130*	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Nonsense_Mutation_p.E130*			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	130					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGAAAACCACGAGAAGGACTG	0.498000													27	111					8.4185e-14	1.29674e-13	0.012213	1	0
ARAP3	64411	broad.mit.edu	37	5	141051740	141051740	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:141051740G>A	ENST00000239440.4	-	10	1579	c.1514C>T	c.(1513-1515)gCg>gTg	p.A505V	ARAP3_ENST00000508305.1_Missense_Mutation_p.A427V|ARAP3_ENST00000513878.1_Missense_Mutation_p.A167V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	505	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCCACAGTCCGCACACTGCCG	0.612000													6	429					0	0	0.001168	0	0
EHHADH	1962	broad.mit.edu	37	3	184910477	184910477	+	Missense_Mutation	SNP	C	C	A	rs151323332		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:184910477C>A	ENST00000231887.3	-	7	1784	c.1709G>T	c.(1708-1710)cGa>cTa	p.R570L	EHHADH_ENST00000456310.1_Missense_Mutation_p.R474L	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	570	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	CTGGCCAAATCGTCCTAATTC	0.468000													14	39					6.31663e-08	8.26527e-08	0.003163	1	0
VASP	7408	broad.mit.edu	37	19	46029247	46029247	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:46029247A>G	ENST00000245932.6	+	12	1447	c.1091A>G	c.(1090-1092)gAg>gGg	p.E364G		NM_003370.3	NP_003361.1	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	364	2 X 15 AA tandem repeats of L-[EQ]-[KR]- [MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]- [KRV]-[KQ]-E.|EVH2 block C.|EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)	18		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		AAAGTGAAAGAGGAAATCATT	0.428000													28	219					0	0	0.006320	0	0
CYP2A7	1549	broad.mit.edu	37	19	41383234	41383234	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:41383234G>T	ENST00000301146.4	-	7	1563	c.1022C>A	c.(1021-1023)cCc>cAc	p.P341H	CYP2A7_ENST00000291764.3_Missense_Mutation_p.P290H|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	341						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTCAAACTTGGGCTGCCGGTT	0.552000													13	23					3.41278e-10	4.88017e-10	0.004990	1	0
CD163L1	283316	broad.mit.edu	37	12	7531614	7531614	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:7531614A>T	ENST00000313599.3	-	9	2388	c.2331T>A	c.(2329-2331)acT>acA	p.T777T	CD163L1_ENST00000544331.1_5'UTR|CD163L1_ENST00000416109.2_Silent_p.T787T|CD163L1_ENST00000396630.1_Silent_p.T777T			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	777	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AATGACACGCAGTCTGTTTCC	0.358000													8	16					0	0	0.003163	0	0
NCAPH2	29781	broad.mit.edu	37	22	50955911	50955911	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:50955911G>T	ENST00000395701.3	+	3	360	c.266_splice	c.e3+1	p.R89_splice	NCAPH2_ENST00000420993.2_Splice_Site_p.R89_splice|NCAPH2_ENST00000299821.11_Splice_Site_p.R89_splice|NCAPH2_ENST00000395698.3_Splice_Site_p.R89_splice			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	89					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		TCTGGAAAGAGGTGAGTTCTG	0.607000													4	15					1.23904e-05	1.47209e-05	0.014758	1	0
ZNF536	9745	broad.mit.edu	37	19	30935951	30935951	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30935951C>T	ENST00000355537.3	+	2	1629	c.1482C>T	c.(1480-1482)ctC>ctT	p.L494L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCCTCAATCTCGTGCCGCCGC	0.652000													5	28					0	0	0.004482	0	0
AK1	203	broad.mit.edu	37	9	130630759	130630759	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:130630759G>A	ENST00000373176.1	-	6	509	c.357C>T	c.(355-357)gaC>gaT	p.D119D	RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000373156.1_Silent_p.D119D|AK1_ENST00000223836.10_Silent_p.D135D	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	119					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						CAGGGCCTGCGTCCACATACA	0.612000													3	3					0	0	0.009096	0	0
LRP4	4038	broad.mit.edu	37	11	46921927	46921927	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:46921927G>T	ENST00000378623.1	-	3	444	c.202C>A	c.(202-204)Cta>Ata	p.L68I		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	68					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CAGGTAGGTAGTACTGAATCC	0.493000													11	84					1.15088e-07	1.49037e-07	0.004007	1	0
NEUROD4	58158	broad.mit.edu	37	12	55420716	55420716	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:55420716C>G	ENST00000242994.3	+	2	871	c.493C>G	c.(493-495)Ccc>Gcc	p.P165A		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	165					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GCTCTCTCAGCCCACAAGCAA	0.527000													5	116					0	0	0.003080	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081224	143081224	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:143081224T>C	ENST00000367603.2	-	9	6943	c.6201A>G	c.(6199-6201)aaA>aaG	p.K2067K	HIVEP2_ENST00000367604.1_Silent_p.K2067K|HIVEP2_ENST00000012134.2_Silent_p.K2067K	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	2067	10 X 4 AA tandem repeats of S-P-[RGMKC]- [RK].				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ATAAATCTCCTTTGGGTATCA	0.463000													20	43					0	0	0.018920	0	0
RFX6	222546	broad.mit.edu	37	6	117248703	117248703	+	Splice_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:117248703G>A	ENST00000332958.2	+	17	2414		c.e17+1			NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6						glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TCACCAAATGGTATTGATATT	0.398000													7	18					0	0	0.006214	0	0
AFF2	2334	broad.mit.edu	37	X	148059468	148059468	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:148059468C>G	ENST00000370460.2	+	17	3889	c.3410C>G	c.(3409-3411)gCa>gGa	p.A1137G	AFF2_ENST00000370457.5_Missense_Mutation_p.A1102G|AFF2_ENST00000286437.5_Missense_Mutation_p.A778G|AFF2_ENST00000342251.3_Missense_Mutation_p.A1104G	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1137					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAGGTATGCAATGAGGCTG	0.433000													80	210					0	0	0.014410	0	0
PKHD1	5314	broad.mit.edu	37	6	51512866	51512866	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:51512866T>A	ENST00000371117.3	-	63	11636	c.11361A>T	c.(11359-11361)tcA>tcT	p.S3787S		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3787					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCAGGGAAGCTGAAATTGTCC	0.423000													17	58					0	0	0.014323	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063773	247063773	+	Splice_Site	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:247063773T>A	ENST00000366508.1	-	9	1359		c.e9-2		AHCTF1_ENST00000391829.2_Splice_Site|AHCTF1_ENST00000326225.3_Splice_Site			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1						cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GCGATAGAGCTGGAAGAAAAA	0.328000													14	27					0	0	0.004990	0	0
EPB41L3	23136	broad.mit.edu	37	18	5419722	5419722	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:5419722C>G	ENST00000341928.2	-	12	1834	c.1494G>C	c.(1492-1494)cgG>cgC	p.R498R	EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000542146.1_5'UTR|EPB41L3_ENST00000342933.3_Silent_p.R498R|EPB41L3_ENST00000544123.1_Silent_p.R516R|EPB41L3_ENST00000540638.2_Silent_p.R516R|EPB41L3_ENST00000400111.3_Silent_p.R516R|EPB41L3_ENST00000427684.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	498	Hydrophilic.			R -> Q (in Ref. 1; AAC79806).	cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TTCCCTCGTGCCGGATGGCCG	0.547000													4	58					0	0	0.010729	0	0
PDZRN4	29951	broad.mit.edu	37	12	41946494	41946494	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:41946494C>G	ENST00000298919.7	+	6	848	c.460C>G	c.(460-462)Ctg>Gtg	p.L154V	PDZRN4_ENST00000402685.2_Missense_Mutation_p.L414V|PDZRN4_ENST00000539469.2_Missense_Mutation_p.L156V			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	414	Gly-rich.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCAAGAGAAGCTGGGCCTGAC	0.468000													16	37					0	0	0.010504	0	0
L1CAM	3897	broad.mit.edu	37	X	153132828	153132828	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:153132828A>G	ENST00000370060.1	-	17	2309	c.2120T>C	c.(2119-2121)gTg>gCg	p.V707A	L1CAM_ENST00000361699.4_Missense_Mutation_p.V707A|L1CAM_ENST00000361981.3_Missense_Mutation_p.V702A|L1CAM_ENST00000370055.1_Missense_Mutation_p.V702A|L1CAM_ENST00000370057.3_Missense_Mutation_p.V707A|L1CAM_ENST00000543994.1_Missense_Mutation_p.V709A|L1CAM_ENST00000538883.1_Missense_Mutation_p.V709A	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	707	Fibronectin type-III 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGTGTGACCACAGTCTCAGA	0.607000													12	24					0	0	0.004007	0	0
COL5A3	50509	broad.mit.edu	37	19	10116529	10116529	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:10116529C>A	ENST00000264828.3	-	3	465	c.380G>T	c.(379-381)gGt>gTt	p.G127V		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	127	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCTAGGAGACCCAGCGCTGG	0.642000													4	5					0.000602214	0.000662587	0.014758	1	0
DNTTIP1	116092	broad.mit.edu	37	20	44433786	44433786	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:44433786G>T	ENST00000372622.3	+	9	673	c.603_splice	c.e9-1	p.W202_splice		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	202						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				TTTGCACAGTGGGACCCAGCT	0.483000													56	105					8.3131e-28	1.47751e-27	0.014410	1	0
COL1A2	1278	broad.mit.edu	37	7	94054489	94054489	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:94054489G>C	ENST00000297268.6	+	42	3205	c.2734G>C	c.(2734-2736)Gtg>Ctg	p.V912L		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	912					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCCTGGTGCTGTGGGTAGTCC	0.517000										HNSCC(75;0.22)			10	19					0	0	0.016723	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148080900	148080900	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:148080900C>A	ENST00000361727.3	+	22	4151	c.3635C>A	c.(3634-3636)tCc>tAc	p.S1212Y	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Missense_Mutation_p.S271Y	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1212	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGGTGGAGTCCAACTGCGGG	0.632000										HNSCC(39;0.1)			4	11					3.59834e-05	4.21245e-05	0.001168	1	0
CPO	130749	broad.mit.edu	37	2	207827200	207827200	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:207827200A>G	ENST00000272852.3	+	7	685	c.639A>G	c.(637-639)ccA>ccG	p.P213P		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	213					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		TGTCTGAACCAGAGACTAAAG	0.453000													46	102					0	0	0.014410	0	0
AMICA1	120425	broad.mit.edu	37	11	118065129	118065129	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:118065129G>T	ENST00000292067.7	-	9	1507	c.1066C>A	c.(1066-1068)Cca>Aca	p.P356T	AMICA1_ENST00000533261.1_Missense_Mutation_p.P355T|AMICA1_ENST00000356289.5_Missense_Mutation_p.P366T|AMICA1_ENST00000526620.1_Missense_Mutation_p.P327T	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	366					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GGCCAAACTGGGTGCTGTGGG	0.468000													14	24					4.36969e-10	6.22823e-10	0.016723	1	0
TARSL2	123283	broad.mit.edu	37	15	102252198	102252198	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:102252198A>G	ENST00000335968.3	-	5	913	c.697T>C	c.(697-699)Tgg>Cgg	p.W233R		NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	233					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTGGAGTGCCAGTACACCTGC	0.428000													7	18					0	0	0.001984	0	0
OR5L2	26338	broad.mit.edu	37	11	55595287	55595287	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:55595287T>A	ENST00000378397.1	+	1	593	c.593T>A	c.(592-594)cTg>cAg	p.L198Q		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				AATGAGACACTGCTGTTCCTG	0.448000										HNSCC(27;0.073)			38	83					0	0	0.014410	0	0
LIPI	149998	broad.mit.edu	37	21	15481394	15481394	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:15481394G>T	ENST00000344577.2	-	10	1391	c.1366C>A	c.(1366-1368)Ctt>Att	p.L456I	LIPI_ENST00000536861.1_Missense_Mutation_p.L435I|AP001347.6_ENST00000428809.1_RNA	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	435					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TACCTGCAAAGTGGTGGTCTG	0.323000													32	107					2.20474e-14	3.45055e-14	0.017118	1	0
LYST	1130	broad.mit.edu	37	1	235972212	235972212	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:235972212C>G	ENST00000389794.3	-	5	2080	c.1906G>C	c.(1906-1908)Gct>Cct	p.A636P	LYST_ENST00000536965.1_Missense_Mutation_p.A636P|LYST_ENST00000389793.2_Missense_Mutation_p.A636P			Q99698	LYST_HUMAN	lysosomal trafficking regulator	636					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATATTACAAGCTGCTTTTTTA	0.363000													8	29					0	0	0.008291	0	0
MME	4311	broad.mit.edu	37	3	154862197	154862197	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:154862197A>G	ENST00000460393.1	+	14	1487	c.1367A>G	c.(1366-1368)gAt>gGt	p.D456G	MME_ENST00000360490.2_Missense_Mutation_p.D456G|MME_ENST00000492661.1_Missense_Mutation_p.D456G|MME_ENST00000462745.1_Missense_Mutation_p.D456G|MME_ENST00000493237.1_Missense_Mutation_p.D456G	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	456					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAGACTTTAGATGACCTCACT	0.368000													14	42					0	0	0.007413	0	0
EPHA5	2044	broad.mit.edu	37	4	66233081	66233081	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:66233081C>A	ENST00000273854.3	-	10	2518	c.1918G>T	c.(1918-1920)Ggg>Tgg	p.G640W	EPHA5_ENST00000511294.1_Missense_Mutation_p.G641W|EPHA5_ENST00000354839.4_Missense_Mutation_p.G618W|EPHA5_ENST00000432638.2_Missense_Mutation_p.G477W	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	640					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TTACTGTGCCCATTATGAAAA	0.333000										TSP Lung(17;0.13)			5	20					0.00198382	0.00211897	0.001984	1	0
EDIL3	10085	broad.mit.edu	37	5	83362356	83362356	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:83362356C>A	ENST00000296591.5	-	7	1139	c.721G>T	c.(721-723)Gag>Tag	p.E241*	EDIL3_ENST00000380138.3_Nonsense_Mutation_p.E231*|EDIL3_ENST00000510271.1_5'UTR	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	241	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TTTATATACTCTGGGCTTCCA	0.373000													8	25					7.48243e-07	9.4255e-07	0.006214	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885672	88885672	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:88885672C>G	ENST00000319675.3	-	1	624	c.528G>C	c.(526-528)atG>atC	p.M176I		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	176										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AACTGCAAAGCATGCCAGGCC	0.572000													5	40					0	0	0.001168	0	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760088	119760088	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:119760088G>T	ENST00000304661.5	-	2	1172	c.934C>A	c.(934-936)Cca>Aca	p.P312T	C1GALT1C1_ENST00000371313.2_Missense_Mutation_p.P312T	NM_001011551.2	NP_001011551.1	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	312						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						GAACCATTTGGAGGTAAGAAA	0.388000													21	60					1.96895e-08	2.65144e-08	0.016522	1	0
OR6W1P	89883	broad.mit.edu	37	7	142760414	142760414	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:142760414C>A	ENST00000496192.1	-	0	112					NR_002140.1															central_nervous_system(1)|endometrium(2)|lung(1)|skin(1)	5						GCCAGGTTGCCCAGCAGCATC	0.493000													4	10					1.024e-07	1.33592e-07	0.014758	1	0
SLC23A2	9962	broad.mit.edu	37	20	4837809	4837809	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:4837809C>A	ENST00000379333.1	-	17	2154	c.1762G>T	c.(1762-1764)Gtg>Ttg	p.V588L	SLC23A2_ENST00000338244.1_Missense_Mutation_p.V588L|SLC23A2_ENST00000424750.2_Missense_Mutation_p.V474L	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	588					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CCTTTGCCCACACCCTTCTTC	0.433000													9	28					2.17888e-05	2.56442e-05	0.006214	1	0
DOCK2	1794	broad.mit.edu	37	5	169126444	169126444	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:169126444G>A	ENST00000256935.8	+	12	1194	c.1114G>A	c.(1114-1116)Ggg>Agg	p.G372R		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	372					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCCTCCAAGGGGGACAGTGG	0.512000													9	21					0	0	0.004007	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590108	140590108	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140590108C>A	ENST00000239450.2	+	1	1818	c.1629C>A	c.(1627-1629)agC>agA	p.S543R	PCDHB12_ENST00000541609.1_Missense_Mutation_p.S206R	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		543	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTGAGCAGCGAGGCGCTGG	0.692000													5	18					3.27435e-08	4.36912e-08	0.020292	1	0
ZNF582	147948	broad.mit.edu	37	19	56896007	56896007	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:56896007C>G	ENST00000301310.4	-	5	937	c.779G>C	c.(778-780)tGt>tCt	p.C260S	ZNF582_ENST00000586929.1_Missense_Mutation_p.C260S	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GGCCTTCTCACAATCTTTACA	0.408000													7	11					0	0	0.003080	0	0
VCAN	1462	broad.mit.edu	37	5	82837181	82837181	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:82837181C>T	ENST00000265077.3	+	8	8924	c.8359C>T	c.(8359-8361)Ctt>Ttt	p.L2787F	VCAN_ENST00000343200.5_Missense_Mutation_p.L1800F|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2787	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TACTACCCACCTTATGGATCA	0.428000													21	46					0	0	0.012319	0	0
TRPC7	57113	broad.mit.edu	37	5	135587494	135587494	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:135587494T>C	ENST00000513104.1	-	6	1704	c.1422A>G	c.(1420-1422)ctA>ctG	p.L474L	TRPC7_ENST00000426057.2_Silent_p.L358L|TRPC7_ENST00000355180.3_Silent_p.L413L	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	474					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCCCGAAATCTAGCAGGTTCC	0.582000													9	33					0	0	0.016723	0	0
KIAA1549	57670	broad.mit.edu	37	7	138601712	138601712	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:138601712C>G	ENST00000440172.1	-	2	2708	c.2660G>C	c.(2659-2661)aGc>aCc	p.S887T	KIAA1549_ENST00000422774.1_Missense_Mutation_p.S887T|KIAA1549_ENST00000242365.4_Missense_Mutation_p.S837T	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	887						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGCACCGGTGCTGGTTGTGCT	0.647000			O	BRAF	pilocytic astrocytoma								3	4					0	0	0.009096	0	0
ACTR2	10097	broad.mit.edu	37	2	65473744	65473744	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:65473744G>A	ENST00000260641.5	+	3	403	c.246G>A	c.(244-246)tgG>tgA	p.W82*	ACTR2_ENST00000377982.4_Nonsense_Mutation_p.W87*|ACTR2_ENST00000476840.1_3'UTR|ACTR2_ENST00000542850.1_Nonsense_Mutation_p.W27*	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	82					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						TACGAAATTGGGATGACATGA	0.368000													16	62					0	0	0.004007	0	0
LOC101927648	101927648	broad.mit.edu	37	1	143425009	143425009	+	RNA	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:143425009A>G	ENST00000423249.1	-	0	59																											ctaccttacaagagctcctga	0.393000													4	11					0	0	0.009096	0	0
TET2	54790	broad.mit.edu	37	4	106180775	106180775	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:106180775G>T	ENST00000513237.1	+	7	4663		c.e7-1		TET2_ENST00000380013.4_Splice_Site|TET2_ENST00000545826.1_Splice_Site|TET2_ENST00000540549.1_Splice_Site			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2						cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TGATTTTTCAGGAGAACTTGC	0.413000			"""Mis N, F"""		MDS								3	2					0.004672	0.00494219	0.004672	1	0
ZNF727	442319	broad.mit.edu	37	7	63529350	63529350	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:63529350T>C	ENST00000550760.3	+	2	264	c.85T>C	c.(85-87)Tat>Cat	p.Y29H	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						GCAGCGTTTGTATAGGGATGT	0.398000													4	1					0	0	0.014758	0	0
TMEM252	169693	broad.mit.edu	37	9	71152258	71152258	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:71152258G>T	ENST00000377311.3	-	2	482	c.430C>A	c.(430-432)Cca>Aca	p.P144T		NM_153237.1	NP_694969.1			transmembrane protein 252																		TAAGATGGTGGGGCCTCTGGG	0.577000													13	43					2.23348e-06	2.77369e-06	0.004007	1	0
SIPA1L3	23094	broad.mit.edu	37	19	38610446	38610446	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:38610446G>T	ENST00000222345.6	+	9	3301	c.2792G>T	c.(2791-2793)gGa>gTa	p.G931V		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	931					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATCTTCTATGGACGAGGAGAC	0.542000													7	6					9.70103e-10	1.3628e-09	0.008291	1	0
FANCL	55120	broad.mit.edu	37	2	58468386	58468386	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:58468386C>A	ENST00000402135.3	-	1	99	c.63G>T	c.(61-63)tcG>tcT	p.S21S	FANCL_ENST00000403295.3_Silent_p.S21S|FANCL_ENST00000403676.1_5'UTR|FANCL_ENST00000233741.4_Silent_p.S21S|FANCL_ENST00000540646.1_Silent_p.S21S	NM_001114636.1	NP_001108108.1	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L	21					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)	8						ACACGGTTTTCGACCGGTTCT	0.587000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				12	28					1.3612e-06	1.70005e-06	0.003163	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118354340	118354340	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:118354340G>T	ENST00000528052.1	+	5	500	c.429G>T	c.(427-429)gtG>gtT	p.V143V	PNLIPRP1_ENST00000358834.4_Silent_p.V143V|PNLIPRP1_ENST00000534537.1_Silent_p.V143V			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	143					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TGCGAGTGGTGGGCGCCCAGG	0.592000													8	6					2.17888e-05	2.56442e-05	0.006214	1	0
PAPPA2	60676	broad.mit.edu	37	1	176759055	176759055	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:176759055C>A	ENST00000367662.3	+	18	5990	c.4826C>A	c.(4825-4827)aCc>aAc	p.T1609N		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1609	Sushi 4.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TATGAATGTACCAATGGCTTC	0.483000													21	92					1.22384e-17	2.01979e-17	0.013726	1	0
HTR7	3363	broad.mit.edu	37	10	92509079	92509079	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:92509079G>A	ENST00000371721.3	-	2	1054	c.812C>T	c.(811-813)gCc>gTc	p.A271V	HTR7_ENST00000371719.2_Missense_Mutation_p.A271V|HTR7_ENST00000336152.3_Missense_Mutation_p.A271V|HTR7_ENST00000277874.6_Missense_Mutation_p.A271V			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	271					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CTTGTGTTTGGCAGCACTCTT	0.502000													5	10					0	0	0.001168	0	0
DDX27	55661	broad.mit.edu	37	20	47839548	47839548	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:47839548A>T	ENST00000371764.4	+	3	397	c.388A>T	c.(388-390)Aca>Tca	p.T130S	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	130	Asp/Glu/Lys-rich.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAAAGGAAAACAGAGGTGAG	0.423000													6	35					0	0	0.001984	0	0
OR2T11	127077	broad.mit.edu	37	1	248789889	248789889	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:248789889C>A	ENST00000330803.2	-	1	602	c.541G>T	c.(541-543)Gtt>Ttt	p.V181F		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGTTTCAGAACTGCTGGGATC	0.498000													25	47					2.48779e-11	3.67725e-11	0.005443	1	0
RYR2	6262	broad.mit.edu	37	1	237620013	237620013	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:237620013G>T	ENST00000366574.2	+	16	1907	c.1590G>T	c.(1588-1590)ctG>ctT	p.L530L	RYR2_ENST00000360064.6_Silent_p.L528L|RYR2_ENST00000542537.1_Silent_p.L514L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	530					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATCCATTCTGAATTCTCTGT	0.448000													32	86					6.99958e-10	9.86457e-10	0.006999	1	0
SLC12A6	9990	broad.mit.edu	37	15	34536219	34536219	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:34536219T>A	ENST00000354181.3	-	16	2490	c.1998A>T	c.(1996-1998)ttA>ttT	p.L666F	SLC12A6_ENST00000558667.1_Missense_Mutation_p.L666F|SLC12A6_ENST00000558589.1_Missense_Mutation_p.L657F|SLC12A6_ENST00000290209.5_Missense_Mutation_p.L615F|SLC12A6_ENST00000560611.1_Missense_Mutation_p.L666F|SLC12A6_ENST00000458406.2_Missense_Mutation_p.L607F|SLC12A6_ENST00000560164.1_Missense_Mutation_p.L478F|SLC12A6_ENST00000397707.2_Missense_Mutation_p.L651F|SLC12A6_ENST00000397702.2_Missense_Mutation_p.L607F|SLC12A6_ENST00000451844.2_Missense_Mutation_p.L478F			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	666					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GTGTTCGAAGTAATGTTTGCA	0.388000													21	114					0	0	0.016522	0	0
OR10A5	144124	broad.mit.edu	37	11	6866923	6866923	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:6866923G>T	ENST00000299454.4	+	1	41	c.10G>T	c.(10-12)Gga>Tga	p.G4*	OR10A5_ENST00000379831.2_Nonsense_Mutation_p.G8*			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TATGGCTATAGGAAACTGGAC	0.378000													31	50					1.06647e-15	1.69939e-15	0.017118	1	0
PROKR1	10887	broad.mit.edu	37	2	68882117	68882117	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:68882117C>T	ENST00000303786.3	+	3	1011	c.591C>T	c.(589-591)tcC>tcT	p.S197S	PROKR1_ENST00000394342.2_Silent_p.S197S			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	197						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CCATCCCTTCCGCCTACTTCA	0.562000													15	61					0	0	0.007413	0	0
SLC9C1	285335	broad.mit.edu	37	3	111923162	111923162	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:111923162A>C	ENST00000305815.5	-	17	2327	c.2075T>G	c.(2074-2076)cTt>cGt	p.L692R	SLC9C1_ENST00000487372.1_Missense_Mutation_p.L644R	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	692					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TATTTCAATAAGTATTACATG	0.294000													7	50					0	0	0.001984	0	0
BPGM	669	broad.mit.edu	37	7	134346514	134346514	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:134346514G>T	ENST00000393132.2	+	3	744	c.255G>T	c.(253-255)tgG>tgT	p.W85C	BPGM_ENST00000344924.3_Missense_Mutation_p.W85C|BPGM_ENST00000418040.1_Missense_Mutation_p.W85C	NM_199186.2	NP_954655.1	P07738	PMGE_HUMAN	2,3-bisphosphoglycerate mutase	85					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			breast(1)|endometrium(1)|lung(2)|stomach(1)	5						AAAGCTCCTGGCGTCTAAATG	0.507000													15	72					1.96292e-10	2.8207e-10	0.010504	1	0
CYP4V2	285440	broad.mit.edu	37	4	187118127	187118127	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:187118127G>T	ENST00000378802.4	+	4	751	c.447G>T	c.(445-447)atG>atT	p.M149I		NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	149					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		GGAGAAAGATGTTAACACCCA	0.323000													10	27					0.000673444	0.000733603	0.008291	1	0
AXL	558	broad.mit.edu	37	19	41745202	41745202	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:41745202T>A	ENST00000301178.4	+	9	1458	c.1268T>A	c.(1267-1269)cTg>cAg	p.L423Q	AXL_ENST00000359092.3_Missense_Mutation_p.L423Q|AXL_ENST00000593513.1_Missense_Mutation_p.L155Q	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	423	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.L423Q(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CCAGTACCCCTGGAGGCCTGG	0.597000													11	45					0	0	0.006122	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2022228	2022228	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:2022228G>A	ENST00000382722.5	-	3	749	c.387C>T	c.(385-387)gaC>gaT	p.D129D	CACNA2D4_ENST00000585708.1_Silent_p.D65D|CACNA2D4_ENST00000587995.1_Silent_p.D129D|CACNA2D4_ENST00000586184.1_Silent_p.D129D|CACNA2D4_ENST00000585732.1_Silent_p.D129D|CACNA2D4_ENST00000588077.1_Silent_p.D65D	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	129						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGTTCTCCATGTCCTCTGAGA	0.572000													9	23					0	0	0.006214	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883864	19883864	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:19883864C>A	ENST00000300571.2	-	2	495	c.304G>T	c.(304-306)Ggg>Tgg	p.G102W	GPRC5B_ENST00000569847.1_Missense_Mutation_p.G102W|GPRC5B_ENST00000569479.1_Missense_Mutation_p.G102W|GPRC5B_ENST00000535671.1_Missense_Mutation_p.G102W|GPRC5B_ENST00000537135.1_Missense_Mutation_p.G128W	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	102										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCCAGGGTCCCCAGGAGGAAC	0.597000													8	15					7.48243e-07	9.4255e-07	0.006214	1	0
REG3G	130120	broad.mit.edu	37	2	79255008	79255008	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:79255008C>A	ENST00000272324.5	+	5	593	c.409C>A	c.(409-411)Ccc>Acc	p.P137T	REG3G_ENST00000393897.2_Missense_Mutation_p.P137T|REG3G_ENST00000409471.1_Missense_Mutation_p.P91T	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	137	C-type lectin.				acute-phase response	extracellular region	sugar binding	p.P137A(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGAGAAAAATCCCTCCACCAT	0.517000													24	77					3.28513e-13	5.01625e-13	0.021523	1	0
USP28	57646	broad.mit.edu	37	11	113677221	113677221	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:113677221C>A	ENST00000003302.4	-	19	2458	c.2390G>T	c.(2389-2391)gGg>gTg	p.G797V	USP28_ENST00000544967.1_Intron|USP28_ENST00000260188.5_Intron|USP28_ENST00000545540.1_Intron	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	797					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CTTAATCAGCCCTGCTTCAGA	0.438000													10	9					0.00010058	0.000116044	0.013537	1	0
KLHL41	10324	broad.mit.edu	37	2	170366651	170366651	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:170366651C>A	ENST00000284669.1	+	1	440	c.363C>A	c.(361-363)gtC>gtA	p.V121V	BBS5_ENST00000554017.1_Intron|RP11-724O16.1_ENST00000513963.1_Intron	NM_006063.2	NP_006054.2			kelch-like family member 41																		TGTTTACTGTCTGCGTTTCTT	0.453000													15	31					1.00905e-13	1.55156e-13	0.008871	1	0
PIKFYVE	200576	broad.mit.edu	37	2	209142260	209142260	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:209142260G>T	ENST00000264380.4	+	5	599		c.e5-1		PIKFYVE_ENST00000308862.6_Intron|PIKFYVE_ENST00000392202.3_Intron|PIKFYVE_ENST00000407449.1_Splice_Site	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing						cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TATTGTTATAGGATAGTGACC	0.358000													15	31					5.03518e-11	7.35589e-11	0.007413	1	0
IPO8	10526	broad.mit.edu	37	12	30792623	30792623	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:30792623C>G	ENST00000256079.4	-	21	2653	c.2315G>C	c.(2314-2316)gGg>gCg	p.G772A	IPO8_ENST00000544829.1_Missense_Mutation_p.G567A	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	772					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AGTTTTGACCCCTCGAGTTAA	0.413000													11	61					0	0	0.016723	0	0
PCDH9	5101	broad.mit.edu	37	13	67800785	67800785	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:67800785C>A	ENST00000544246.1	-	2	2479	c.1788G>T	c.(1786-1788)gtG>gtT	p.V596V	PCDH9_ENST00000328454.5_Silent_p.V596V|PCDH9_ENST00000377861.3_Silent_p.V596V|PCDH9_ENST00000456367.1_Silent_p.V596V|PCDH9_ENST00000377865.2_Silent_p.V596V	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	596	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTGCATCTGTCACTGTGATTA	0.373000													46	34					1.78197e-24	3.12913e-24	0.014410	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232650142	232650142	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:232650142C>A	ENST00000366630.1	-	2	1302	c.944G>T	c.(943-945)cGa>cTa	p.R315L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.R315L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	315					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCTCTCCAGTCGGCTCTCCTC	0.463000													28	54					2.61193e-14	4.07331e-14	0.009535	1	0
CEP170	9859	broad.mit.edu	37	1	243336059	243336059	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:243336059A>G	ENST00000366542.1	-	11	1707	c.1656T>C	c.(1654-1656)tcT>tcC	p.S552S	CEP170_ENST00000366544.1_Silent_p.S454S|CEP170_ENST00000366543.1_Silent_p.S454S	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	552						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CTGCTGCAGCAGAACTGAGAG	0.378000													3	7					0	0	0.009096	0	0
IGF2R	3482	broad.mit.edu	37	6	160494822	160494822	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:160494822G>T	ENST00000356956.1	+	35	5129	c.4981G>T	c.(4981-4983)Gtt>Ttt	p.V1661F		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1661					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AAGCTCTATTGTTGACTTGTC	0.418000													16	24					5.35267e-07	6.79139e-07	0.007413	1	0
KLHL12	59349	broad.mit.edu	37	1	202888887	202888887	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:202888887C>A	ENST00000367261.3	-	3	563	c.345G>T	c.(343-345)ttG>ttT	p.L115F	KLHL12_ENST00000435533.3_Missense_Mutation_p.L153F	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	115					Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			CTGTACCTTTCAACTGAAGCA	0.363000													9	16					9.05144e-12	1.34243e-11	0.016723	1	0
CNGB3	54714	broad.mit.edu	37	8	87679295	87679295	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:87679295G>T	ENST00000320005.5	-	6	757	c.710C>A	c.(709-711)cCa>cAa	p.P237Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	237					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GAGGCGCAGTGGTATAAAACA	0.423000													16	45					4.96729e-08	6.55832e-08	0.008871	1	0
MUC20	200958	broad.mit.edu	37	3	195453055	195453055	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:195453055G>T	ENST00000320736.6	+	3	1194	c.1068G>T	c.(1066-1068)agG>agT	p.R356S	MUC20_ENST00000445522.2_Missense_Mutation_p.R492S|MUC20_ENST00000447234.2_Missense_Mutation_p.R527S|MUC20_ENST00000436408.1_Missense_Mutation_p.R527S	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	527	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|Ser-rich.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CAGTTAGCAGGAATCCCCTTG	0.582000													9	27					0.00621372	0.00654154	0.006214	1	0
CCDC158	339965	broad.mit.edu	37	4	77288616	77288616	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:77288616T>A	ENST00000388914.3	-	11	1813	c.1661A>T	c.(1660-1662)aAa>aTa	p.K554I		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	554										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CATCTGCAGTTTGAGGGCCTC	0.512000													9	34					0	0	0.004482	0	0
MPP4	58538	broad.mit.edu	37	2	202554925	202554925	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:202554925C>A	ENST00000409474.3	-	4	486	c.279_splice	c.e4+1	p.E93_splice	MPP4_ENST00000409143.1_Splice_Site_p.E93_splice|MPP4_ENST00000396886.3_Splice_Site_p.E93_splice|MPP4_ENST00000359962.5_Splice_Site_p.E93_splice|MPP4_ENST00000315506.7_Splice_Site_p.E93_splice|MPP4_ENST00000447335.2_Splice_Site_p.E93_splice|MPP4_ENST00000428900.2_Splice_Site_p.E93_splice	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	93	L27 2.					cytoplasm	protein binding			kidney(1)|lung(11)	12						ATCTCCTTACCTCATAGGATA	0.413000													8	25					6.40141e-05	7.44429e-05	0.010729	1	0
SYTL4	94121	broad.mit.edu	37	X	99956282	99956282	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:99956282C>A	ENST00000372981.1	-	4	556	c.370G>T	c.(370-372)Gtg>Ttg	p.V124L	SYTL4_ENST00000454200.2_Missense_Mutation_p.V124L|SYTL4_ENST00000276141.6_Missense_Mutation_p.V124L|SYTL4_ENST00000263033.5_Missense_Mutation_p.V124L|SYTL4_ENST00000455616.1_Missense_Mutation_p.V124L|SYTL4_ENST00000372989.1_Missense_Mutation_p.V124L			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	124					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGCGATTCACTTTCTGGTCA	0.428000													20	75					2.44723e-14	3.82325e-14	0.004656	1	0
KRT15	3866	broad.mit.edu	37	17	39672374	39672374	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:39672374C>A	ENST00000254043.3	-	4	4467	c.882G>T	c.(880-882)gaG>gaT	p.E294D	KRT15_ENST00000393974.3_Missense_Mutation_p.E129D|KRT15_ENST00000393976.2_Missense_Mutation_p.E294D|KRT15_ENST00000393981.3_Missense_Mutation_p.E129D	NM_002275.3	NP_002266.2	P19012	K1C15_HUMAN	keratin 15	294	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				AGAACCAGGCCTCGACATCCC	0.642000													22	43					4.59853e-10	6.53318e-10	0.005443	1	0
SLC26A5	375611	broad.mit.edu	37	7	103018953	103018953	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:103018953C>A	ENST00000306312.3	-	17	1986	c.1725G>T	c.(1723-1725)atG>atT	p.M575I	SLC26A5_ENST00000354356.4_Missense_Mutation_p.M8I|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000393735.2_Intron|SLC26A5_ENST00000432958.2_Missense_Mutation_p.M543I|SLC26A5_ENST00000393727.1_Missense_Mutation_p.M575I|SLC26A5_ENST00000393730.1_Missense_Mutation_p.M543I|SLC26A5_ENST00000339444.6_Missense_Mutation_p.M575I|SLC26A5_ENST00000393723.1_Missense_Mutation_p.M543I|SLC26A5_ENST00000393729.1_Missense_Mutation_p.M538I	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	575	STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CGTACTTCCGCATGGCCTTTC	0.468000													38	115					1.7489e-18	2.90822e-18	0.011902	1	0
MS4A14	84689	broad.mit.edu	37	11	60183516	60183516	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:60183516G>T	ENST00000300187.6	+	5	1352	c.1075G>T	c.(1075-1077)Ggc>Tgc	p.G359C	MS4A14_ENST00000531783.1_Missense_Mutation_p.G392C|MS4A14_ENST00000395001.1_3'UTR|MS4A14_ENST00000395005.2_Missense_Mutation_p.G342C|MS4A14_ENST00000531787.1_Missense_Mutation_p.G247C	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	359						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						GCCCCCTCAAGGcatactatc	0.438000													10	27					0.00185496	0.0019959	0.016723	1	0
STIM2	57620	broad.mit.edu	37	4	27019510	27019510	+	Missense_Mutation	SNP	C	C	T	rs144093498		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:27019510C>T	ENST00000382009.3	+	12	2219	c.1952C>T	c.(1951-1953)tCc>tTc	p.S651F	STIM2_ENST00000237364.5_Missense_Mutation_p.S643F|STIM2_ENST00000467011.1_Missense_Mutation_p.S556F|STIM2_ENST00000467087.1_Missense_Mutation_p.S556F|STIM2_ENST00000465503.1_Missense_Mutation_p.S564F|STIM2_ENST00000412829.2_Missense_Mutation_p.S643F	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	556					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				TCCTTGCCTTCCCCTGATCCA	0.562000													34	210					0	0	0.011902	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304022	151304022	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:151304022C>A	ENST00000370323.4	-	4	387	c.71G>T	c.(70-72)gGc>gTc	p.G24V	MAGEA10_ENST00000244096.3_Missense_Mutation_p.G24V|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	24										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ACCCTCGAGGCCCTGTGTCTC	0.562000													20	53					3.7963e-18	6.30086e-18	0.018920	1	0
TMEM67	91147	broad.mit.edu	37	8	94797464	94797464	+	Silent	SNP	C	C	T	rs5893258		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:94797464C>T	ENST00000453321.3	+	12	1204	c.1146C>T	c.(1144-1146)atC>atT	p.I382I	TMEM67_ENST00000409623.3_Silent_p.I301I	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	382					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AGATTCCTATCTCTAAGATCT	0.274000													40	131					0	0	0.014410	0	0
SLC17A2	10246	broad.mit.edu	37	6	25921243	25921243	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:25921243C>G	ENST00000377850.3	-	5	1077	c.553G>C	c.(553-555)Gca>Cca	p.A185P	SLC17A2_ENST00000265425.3_Missense_Mutation_p.A185P|SLC17A2_ENST00000360488.3_Missense_Mutation_p.A185P			O00624	NPT3_HUMAN	solute carrier family 17, member 2	185					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						CCTGATCCTGCAATGGTGGTG	0.448000													13	53					0	0	0.003163	0	0
TRPV5	56302	broad.mit.edu	37	7	142626181	142626181	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:142626181G>T	ENST00000265310.1	-	5	870	c.522C>A	c.(520-522)aaC>aaA	p.N174K	TRPV5_ENST00000442623.1_Missense_Mutation_p.N174K	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	174					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TCTCCTCGCTGTTCACACAGG	0.617000													12	41					1.02788e-11	1.52189e-11	0.004990	1	0
MTSS1	9788	broad.mit.edu	37	8	125565848	125565848	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:125565848G>T	ENST00000518547.1	-	14	2126	c.1653C>A	c.(1651-1653)aaC>aaA	p.N551K	MTSS1_ENST00000523587.1_5'UTR|MTSS1_ENST00000395508.2_Missense_Mutation_p.N325K|NDUFB9_ENST00000522532.1_Intron|MTSS1_ENST00000431961.2_Missense_Mutation_p.N269K|MTSS1_ENST00000524090.1_Missense_Mutation_p.N441K|MTSS1_ENST00000354184.4_Missense_Mutation_p.N269K|MTSS1_ENST00000325064.5_Missense_Mutation_p.N555K|MTSS1_ENST00000378017.3_Missense_Mutation_p.N526K	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	551					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGATGTCGCTGTTTCTTGGAA	0.517000													4	18					5.4927e-09	7.47689e-09	0.004482	1	0
RYR2	6262	broad.mit.edu	37	1	237995920	237995920	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:237995920G>T	ENST00000366574.2	+	105	15194	c.14877G>T	c.(14875-14877)cgG>cgT	p.R4959R	RYR2_ENST00000462585.1_3'UTR|RYR2_ENST00000360064.6_Silent_p.R4965R|RYR2_ENST00000542537.1_Silent_p.R4943R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4959			R -> Q (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTGCTTCCGGAAACAGTATG	0.408000													12	44					0.000219431	0.000250209	0.020292	1	0
TMEM132B	114795	broad.mit.edu	37	12	126068497	126068497	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:126068497C>T	ENST00000299308.3	+	5	1387	c.1379C>T	c.(1378-1380)tCt>tTt	p.S460F		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	460						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTCGATGTGTCTGAGTCTGTG	0.488000													63	126					0	0	0.014410	0	0
DNAH7	56171	broad.mit.edu	37	2	196825392	196825392	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:196825392C>A	ENST00000312428.6	-	18	2583	c.2483G>T	c.(2482-2484)aGa>aTa	p.R828I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	828	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CACCTTTGATCTTACTTTTTT	0.413000													28	81					7.68411e-24	1.34128e-23	0.008361	1	0
ZBTB38	253461	broad.mit.edu	37	3	141163054	141163054	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:141163054A>T	ENST00000514251.1	+	4	2103	c.1824A>T	c.(1822-1824)ccA>ccT	p.P608P	ZBTB38_ENST00000441582.2_Silent_p.P608P|ZBTB38_ENST00000321464.5_Silent_p.P609P			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	608					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						TTCAGAATCCACACAGCTCTG	0.438000													21	45					0	0	0.012319	0	0
GPR101	83550	broad.mit.edu	37	X	136113088	136113088	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:136113088C>A	ENST00000298110.1	-	1	745	c.746G>T	c.(745-747)gGa>gTa	p.G249V		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	249						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CTTCTCTGCTCCCTCTTCATC	0.552000													59	211					5.98616e-33	1.09497e-32	0.014410	1	0
ALDH1A1	216	broad.mit.edu	37	9	75520889	75520889	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:75520889C>G	ENST00000297785.3	-	12	1472	c.1418G>C	c.(1417-1419)gGa>gCa	p.G473A		NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	473					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCTTCCATTTCCAGACATCTT	0.353000													4	9					0	0	0.009096	0	0
DMD	1756	broad.mit.edu	37	X	31854905	31854905	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:31854905G>T	ENST00000357033.4	-	49	7336	c.7130C>A	c.(7129-7131)cCg>cAg	p.P2377Q	DMD_ENST00000474231.1_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000378677.2_Missense_Mutation_p.P2373Q|DMD_ENST00000359836.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000343523.2_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2377					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCCACATCCGGTTGTTTAGC	0.373000													37	69					4.14481e-20	7.02537e-20	0.006230	1	0
BCORL1	63035	broad.mit.edu	37	X	129168530	129168530	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:129168530G>T	ENST00000303743.5	+	9	4520	c.4406G>T	c.(4405-4407)aGc>aTc	p.S1469I	BCORL1_ENST00000540052.1_Intron|BCORL1_ENST00000218147.7_Intron|BCORL1_ENST00000359304.2_Intron			Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1445					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CGAAGTGCCAGCTCAGAGGAG	0.577000													5	10					0.00198382	0.00211897	0.001984	1	0
CFHR1	3078	broad.mit.edu	37	1	196795979	196795979	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:196795979G>T	ENST00000320493.5	+	3	362	c.274G>T	c.(274-276)Gtg>Ttg	p.V92L	CFHR1_ENST00000367424.3_Missense_Mutation_p.V92L|CFHR1_ENST00000498248.1_3'UTR|CFHR2_ENST00000367421.3_Intron	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	92	Sushi 2.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						CTTTCCTTTTGTGGAAAATGG	0.333000													17	17					3.41278e-10	4.88017e-10	0.004990	1	0
PLB1	151056	broad.mit.edu	37	2	28826903	28826903	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:28826903C>G	ENST00000422425.2	+	39	2856	c.2812C>G	c.(2812-2814)Cga>Gga	p.R938G	PLB1_ENST00000541605.1_Intron|PLB1_ENST00000327757.5_Missense_Mutation_p.R949G	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	949	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GGCCTTCAGCCGAGCCTACCG	0.607000													12	2					0	0	0.020292	0	0
OR2T3	343173	broad.mit.edu	37	1	248637470	248637470	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:248637470T>A	ENST00000359594.2	+	1	844	c.819T>A	c.(817-819)gcT>gcA	p.A273A		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCACACAGCTGAGCAGGACA	0.537000													58	369					0	0	0.014410	0	0
RPL10	6134	broad.mit.edu	37	X	153627737	153627737	+	Translation_Start_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:153627737G>A	ENST00000406022.2	+	0	130				RPL10_ENST00000424325.2_Splice_Site_p.D28_splice|RPL10_ENST00000369817.2_Splice_Site_p.D28_splice			P27635	RL10_HUMAN	ribosomal protein L10						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome			large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGTGTCCCTGGTAAGTAGTG	0.537000											OREG0019957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	15					0	0	0.005443	0	0
ATP1B4	23439	broad.mit.edu	37	X	119509380	119509380	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:119509380G>T	ENST00000218008.3	+	5	773	c.716G>T	c.(715-717)gGa>gTa	p.G239V	ATP1B4_ENST00000361319.3_Missense_Mutation_p.G235V|ATP1B4_ENST00000539306.1_Missense_Mutation_p.G196V	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	239					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						CCAACTTTTGGATACTCTACT	0.468000													59	114					6.26901e-30	1.12791e-29	0.014410	1	0
PIGG	54872	broad.mit.edu	37	4	527748	527748	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:527748T>C	ENST00000453061.2	+	12	2819	c.2713T>C	c.(2713-2715)Ttc>Ctc	p.F905L	PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000310340.5_Missense_Mutation_p.F897L|PIGG_ENST00000504346.1_Missense_Mutation_p.F816L|PIGG_ENST00000383028.4_Missense_Mutation_p.F772L	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	905					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CTTAGTGCACTTCCTGAGCTC	0.597000													4	15					0	0	0.003080	0	0
EDC4	23644	broad.mit.edu	37	16	67914657	67914657	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:67914657G>A	ENST00000358933.5	+	18	2534	c.2295G>A	c.(2293-2295)gaG>gaA	p.E765E		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	765					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		AGGGCCTTGAGCCAGACAGTA	0.662000													8	30					0	0	0.013537	0	0
CACNA1B	774	broad.mit.edu	37	9	140952560	140952560	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:140952560G>A	ENST00000277549.5	+	29	4323	c.1754G>A	c.(1753-1755)cGc>cAc	p.R585H	CACNA1B_ENST00000371363.1_Missense_Mutation_p.R1389H|CACNA1B_ENST00000277551.2_Missense_Mutation_p.R1389H|CACNA1B_ENST00000371372.1_Missense_Mutation_p.R1389H|CACNA1B_ENST00000371355.4_Missense_Mutation_p.R1390H|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R1390H			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1389					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCTGGGTACCGCATGGAGCTG	0.537000													4	49					0	0	0.001984	0	0
LRRC52	440699	broad.mit.edu	37	1	165532869	165532869	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:165532869C>A	ENST00000294818.1	+	2	1040	c.750C>A	c.(748-750)ctC>ctA	p.L250L	RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000438275.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	250						integral to membrane				NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TCCTGCTGCTCATCGGCTTCT	0.592000													6	20					4.7546e-09	6.49229e-09	0.004007	1	0
COL15A1	1306	broad.mit.edu	37	9	101818567	101818567	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:101818567G>T	ENST00000375001.3	+	35	3641	c.3218G>T	c.(3217-3219)gGg>gTg	p.G1073V		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1073	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				ACAGTCGTTGGGCCCCAAGGA	0.592000													22	28					1.87028e-06	2.32923e-06	0.012319	1	0
FGL2	10875	broad.mit.edu	37	7	76826219	76826219	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:76826219G>T	ENST00000248598.5	-	2	729	c.697C>A	c.(697-699)Ccc>Acc	p.P233T	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron|RP11-467H10.2_ENST00000459742.1_RNA	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	233	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CTATTTTTGGGATCAGGTGTA	0.453000													22	45					4.4004e-07	5.59935e-07	0.018920	1	0
LOC101927079	101927079	broad.mit.edu	37	15	22332698	22332698	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:22332698G>T	ENST00000558896.1	+	0	505																											TCTTTTTCAGGATGCCTGGCC	0.463000													12	44					2.32078e-09	3.21396e-09	0.003163	1	0
PCDHA8	56140	broad.mit.edu	37	5	140221203	140221203	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140221203C>G	ENST00000531613.1	+	1	297	c.297C>G	c.(295-297)agC>agG	p.S99R	PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S99R|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGGCGGAGCGCGGAGTGCA	0.572000													10	28					0	0	0.006122	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261268	21261268	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:21261268G>C	ENST00000311620.5	+	2	454	c.381G>C	c.(379-381)atG>atC	p.M127I		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	127										NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		AGAACATCATGAACCCCAAGA	0.517000													6	18					0	0	0.016723	0	0
LTBP1	4052	broad.mit.edu	37	2	33477883	33477883	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:33477883C>G	ENST00000404816.2	+	11	2492	c.2139C>G	c.(2137-2139)caC>caG	p.H713Q	LTBP1_ENST00000402934.1_Missense_Mutation_p.H387Q|LTBP1_ENST00000404525.1_Missense_Mutation_p.H387Q|LTBP1_ENST00000407925.1_Missense_Mutation_p.H387Q|LTBP1_ENST00000390003.4_Missense_Mutation_p.H387Q|LTBP1_ENST00000418533.2_Missense_Mutation_p.H387Q|LTBP1_ENST00000354476.3_Missense_Mutation_p.H713Q			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	713	TB 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGGGCCCACACTGTGAGAAAT	0.542000													14	42					0	0	0.004007	0	0
TEX10	54881	broad.mit.edu	37	9	103084052	103084052	+	Splice_Site	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:103084052A>C	ENST00000374902.4	-	10	2157	c.1979_splice	c.e10-1	p.S661_splice	TEX10_ENST00000535814.1_Splice_Site_p.S664_splice	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	661						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		GAAAATGATGATCTATAAAAA	0.358000													8	32					0	0	0.004482	0	0
CA5B	11238	broad.mit.edu	37	X	15794885	15794885	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:15794885A>G	ENST00000318636.3	+	7	803	c.667A>G	c.(667-669)Acc>Gcc	p.T223A	CA5B_ENST00000454127.2_Missense_Mutation_p.T223A	NM_007220.3	NP_009151.1	Q9Y2D0	CAH5B_HUMAN	carbonic anhydrase VB, mitochondrial	223					one-carbon metabolic process	mitochondrion	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(2)|lung(3)|prostate(1)|stomach(2)	9	Hepatocellular(33;0.183)					CCTGATGCCTACCTGCCCAGA	0.498000													24	44					0	0	0.015359	0	0
SLC25A32	81034	broad.mit.edu	37	8	104413780	104413780	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:104413780T>C	ENST00000297578.4	-	6	942	c.776A>G	c.(775-777)tAc>tGc	p.Y259C	SLC25A32_ENST00000523701.1_5'UTR|SLC25A32_ENST00000543107.1_Missense_Mutation_p.Y127C	NM_030780.3	NP_110407.2	Q9H2D1	MFTC_HUMAN	solute carrier family 25 (mitochondrial folate carrier), member 32	259					folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	9			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	TACACCACTGTAAAACATGTG	0.393000													21	58					0	0	0.014323	0	0
ZNF536	9745	broad.mit.edu	37	19	30936551	30936551	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30936551C>G	ENST00000355537.3	+	2	2229	c.2082C>G	c.(2080-2082)gtC>gtG	p.V694V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	694					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCTCTAACGTCACCGAGGAGA	0.697000													4	10					0	0	0.001984	0	0
CHRM3	1131	broad.mit.edu	37	1	240070931	240070931	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:240070931G>A	ENST00000255380.4	+	5	959	c.180G>A	c.(178-180)ctG>ctA	p.L60L		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	60					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ATGACCCTCTGGGAGGTCATA	0.542000													6	21					0	0	0.013537	0	0
OR1K1	392392	broad.mit.edu	37	9	125563218	125563218	+	Missense_Mutation	SNP	C	C	A	rs150392492		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:125563218C>A	ENST00000277309.2	+	1	849	c.817C>A	c.(817-819)Cgt>Agt	p.R273S		NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						AGAGTGGGGCCGTGTGGCCAC	0.597000													17	46					8.16277e-20	1.37297e-19	0.006999	1	0
CHUK	1147	broad.mit.edu	37	10	101959779	101959779	+	Splice_Site	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:101959779T>C	ENST00000370397.7	-	16	1766		c.e16-2			NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CGCTGTTCCCTATAAAAGAGA	0.333000													17	29					0	0	0.004990	0	0
NCAPD3	23310	broad.mit.edu	37	11	134047240	134047240	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:134047240C>G	ENST00000534548.2	-	23	2959	c.2895G>C	c.(2893-2895)atG>atC	p.M965I		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	965					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		AGAGATCGCACATTACAATGA	0.522000													18	38					0	0	0.010504	0	0
NDST4	64579	broad.mit.edu	37	4	115997623	115997623	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:115997623T>C	ENST00000264363.2	-	2	1248	c.570A>G	c.(568-570)ctA>ctG	p.L190L		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	190	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AACAGTCCTTTAGAGCTAGAT	0.403000													24	41					0	0	0.008361	0	0
USP16	10600	broad.mit.edu	37	21	30400249	30400249	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:30400249G>A	ENST00000334352.4	+	3	246	c.15G>A	c.(13-15)cgG>cgA	p.R5R	USP16_ENST00000535828.1_Intron|USP16_ENST00000399976.2_Silent_p.R5R|USP16_ENST00000399975.3_Silent_p.R5R	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	5					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						GAAAGAAACGGACAAAGGGAA	0.294000													7	51					0	0	0.010729	0	0
ZNF536	9745	broad.mit.edu	37	19	30936612	30936612	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30936612C>T	ENST00000355537.3	+	2	2290	c.2143C>T	c.(2143-2145)Ccg>Tcg	p.P715S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGAGGACAGCCCGCACCCCTC	0.677000													6	10					0	0	0.001168	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202211387	202211387	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:202211387G>T	ENST00000405148.2	-	5	689	c.246C>A	c.(244-246)aaC>aaA	p.N82K	ALS2CR12_ENST00000439709.1_Missense_Mutation_p.N82K|ALS2CR12_ENST00000286190.5_Missense_Mutation_p.N82K|ALS2CR12_ENST00000448967.1_5'UTR|ALS2CR12_ENST00000392257.3_Missense_Mutation_p.N82K	NM_139163.2	NP_631902.2	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	82					regulation of GTPase activity		protein binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)	21						CAGGTGACACGTTGATCACTT	0.438000													54	177					1.77791e-30	3.21857e-30	0.014410	1	0
NAV3	89795	broad.mit.edu	37	12	78415527	78415527	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:78415527G>T	ENST00000397909.2	+	9	2081	c.1907_splice	c.e9-1	p.R636_splice	NAV3_ENST00000536525.2_Splice_Site_p.R636_splice|NAV3_ENST00000266692.7_Splice_Site_p.R636_splice|NAV3_ENST00000228327.6_Splice_Site_p.R636_splice			Q8IVL0	NAV3_HUMAN	neuron navigator 3	636						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTAATTTCAGGGCACATTCAG	0.368000										HNSCC(70;0.22)			25	100					2.2171e-23	3.84707e-23	0.009535	1	0
AFF1	4299	broad.mit.edu	37	4	87967859	87967859	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:87967859G>T	ENST00000307808.6	+	3	571	c.151G>T	c.(151-153)Gat>Tat	p.D51Y	AFF1_ENST00000544085.1_Intron|AFF1_ENST00000395146.4_Missense_Mutation_p.D58Y	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	51						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AGCAAAAGGTGATGAGCTGTC	0.358000													90	302					1.2656e-43	2.37944e-43	0.014410	1	0
HTATSF1	27336	broad.mit.edu	37	X	135594124	135594124	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:135594124T>C	ENST00000535601.1	+	10	2642	c.2220T>C	c.(2218-2220)acT>acC	p.T740T	HTATSF1_ENST00000218364.4_Silent_p.T740T	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	740	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					CCCTATCCACTGGCAGCAGCT	0.453000													30	220					0	0	0.014410	0	0
OR4D2	124538	broad.mit.edu	37	17	56247586	56247586	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:56247586T>A	ENST00000545221.1	+	1	570	c.570T>A	c.(568-570)acT>acA	p.T190T		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						TTGCCTGCACTGACACCTCAC	0.517000													33	121					0	0	0.017118	0	0
TRIM9	114088	broad.mit.edu	37	14	51489585	51489585	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:51489585G>T	ENST00000298355.3	-	3	2130	c.1009C>A	c.(1009-1011)Cgc>Agc	p.R337S	TRIM9_ENST00000338969.5_Missense_Mutation_p.R337S|TRIM9_ENST00000360392.4_Missense_Mutation_p.R337S	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	337					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					TTGTTGACGCGGGCCAGCAGC	0.557000													21	46					7.87624e-14	1.21535e-13	0.016522	1	0
OR51G2	81282	broad.mit.edu	37	11	4936211	4936211	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:4936211C>A	ENST00000322013.3	-	1	711	c.683G>T	c.(682-684)cGc>cTc	p.R228L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCACGGTGCGCAGGATCAG	0.522000													11	17					2.80697e-09	3.86289e-09	0.010729	1	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994747	45994747	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:45994747C>A	ENST00000400374.3	+	1	1142	c.1112C>A	c.(1111-1113)cCc>cAc	p.P371H	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	371	36 X 5 AA repeats of C-C-X(3).					keratin filament		p.P371H(1)		NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GTGTGCAGGCCCGCCTGCTGC	0.692000													11	19					6.21321e-17	1.00835e-16	0.016522	1	0
CCDC108	255101	broad.mit.edu	37	2	219869057	219869057	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:219869057G>A	ENST00000341552.5	-	33	5255	c.5172C>T	c.(5170-5172)agC>agT	p.S1724S	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Silent_p.S1724S|CCDC108_ENST00000441968.1_Silent_p.S1724S	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1724						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTAAGTACAGGCTGTTTTTCT	0.542000													7	13					0	0	0.001984	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123216048	123216048	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:123216048G>A	ENST00000349780.4	-	21	2658	c.2479C>T	c.(2479-2481)Cct>Tct	p.P827S	CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.P827S|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.P827S|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.P795S	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	827					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						TTTTGCTTAGGTGTCTTCTCA	0.438000													43	99					0	0	0.013114	0	0
FYN	2534	broad.mit.edu	37	6	112020718	112020718	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:112020718C>A	ENST00000368682.3	-	9	1074	c.853_splice	c.e9+1	p.G285_splice	FYN_ENST00000229471.4_Intron|FYN_ENST00000368667.2_Intron|FYN_ENST00000354650.3_Intron|FYN_ENST00000356013.2_Intron|FYN_ENST00000368678.4_Splice_Site_p.G285_splice|FYN_ENST00000476769.2_Intron|FYN_ENST00000538466.1_Splice_Site_p.G285_splice|FYN_ENST00000229470.5_Splice_Site_p.G236_splice			P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	288	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCTGCCTTACCAAGCCACACT	0.473000													18	58					8.16721e-17	1.32059e-16	0.010818	1	0
OR4F17	81099	broad.mit.edu	37	19	110736	110736	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:110736C>A	ENST00000585993.1	+	2	197	c.58C>A	c.(58-60)Cta>Ata	p.L20I	OR4F17_ENST00000318050.3_Missense_Mutation_p.L20I			Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F, member 17	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(2)	2		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGACCTTCCTATTTATGTT	0.403000													54	416					5.5144e-22	9.5308e-22	0.014410	1	0
NCKAP5	344148	broad.mit.edu	37	2	133541934	133541934	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:133541934A>G	ENST00000409261.1	-	14	2823	c.2450T>C	c.(2449-2451)aTg>aCg	p.M817T	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.M817T	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	817							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTCGGGCTCCATTAGTTTTGA	0.473000													44	130					0	0	0.014410	0	0
GLRX5	51218	broad.mit.edu	37	14	96010439	96010439	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:96010439A>T	ENST00000331334.4	+	2	948	c.451A>T	c.(451-453)Aag>Tag	p.K151*	GLRX5_ENST00000553672.1_3'UTR	NM_016417.2	NP_057501.2	Q86SX6	GLRX5_HUMAN	glutaredoxin 5	151					cell redox homeostasis|hemopoiesis	mitochondrion	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|protein disulfide oxidoreductase activity			large_intestine(1)|lung(1)	2		all_cancers(154;0.135)		Epithelial(152;0.133)|COAD - Colon adenocarcinoma(157;0.21)|all cancers(159;0.212)		TTTAGATGAAAAGAAAGACCA	0.517000													11	17					0	0	0.016723	0	0
PAN2	9924	broad.mit.edu	37	12	56712181	56712181	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:56712181C>G	ENST00000425394.2	-	25	3790	c.3414G>C	c.(3412-3414)gaG>gaC	p.E1138D	PAN2_ENST00000548043.1_Missense_Mutation_p.E1138D|PAN2_ENST00000440411.3_Missense_Mutation_p.E1134D|PAN2_ENST00000257931.5_Missense_Mutation_p.E1137D|PAN2_ENST00000549090.1_5'UTR	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	1138	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGCGGGCATCCTCAATACTGT	0.502000													9	18					0	0	0.020292	0	0
SETBP1	26040	broad.mit.edu	37	18	42449213	42449213	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:42449213C>T	ENST00000282030.5	+	3	801	c.505C>T	c.(505-507)Ctt>Ttt	p.L169F	SETBP1_ENST00000426838.4_Missense_Mutation_p.L169F	NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	169						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AGCCAGTGACCTTGCAGCCAG	0.433000									Schinzel-Giedion syndrome				17	38					0	0	0.012319	0	0
CD22	933	broad.mit.edu	37	19	35832042	35832042	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:35832042G>T	ENST00000085219.5	+	7	1573		c.e7+1		CD22_ENST00000341773.6_Splice_Site|CD22_ENST00000594250.1_Splice_Site|CD22_ENST00000536635.2_Splice_Site|CD22_ENST00000270311.6_Splice_Site|CD22_ENST00000419549.2_Splice_Site|CD22_ENST00000544992.2_Splice_Site	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule						cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AATGTCCAGTGTGAGTCCCTG	0.607000													31	80					7.04047e-22	1.21445e-21	0.005524	1	0
KCTD16	57528	broad.mit.edu	37	5	143586460	143586460	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:143586460G>T	ENST00000507359.2	+	2	1274	c.183G>T	c.(181-183)acG>acT	p.T61T	KCTD16_ENST00000512467.1_Silent_p.T61T	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	61	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AGAGAGACACGGCTAATGATC	0.458000													10	31					0.00829132	0.00869746	0.008291	1	0
NCR1	9437	broad.mit.edu	37	19	55420766	55420766	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:55420766C>A	ENST00000594765.1	+	4	543	c.518C>A	c.(517-519)gCg>gAg	p.A173E	NCR1_ENST00000598576.1_Missense_Mutation_p.A161E|NCR1_ENST00000357397.5_Missense_Mutation_p.A66E|NCR1_ENST00000338835.5_Missense_Mutation_p.A173E|NCR1_ENST00000291890.4_Missense_Mutation_p.A173E|NCR1_ENST00000350790.5_Missense_Mutation_p.A78E|NCR1_ENST00000447255.1_Missense_Mutation_p.A173E			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	173	Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity	p.A173V(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		AAGGTCCAGGCGGAGTTCCCC	0.572000													27	33					6.53348e-20	1.10528e-19	0.017118	1	0
PYHIN1	149628	broad.mit.edu	37	1	158914669	158914669	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:158914669A>T	ENST00000368140.1	+	7	1441	c.1196A>T	c.(1195-1197)cAg>cTg	p.Q399L	PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000368138.3_Missense_Mutation_p.Q390L|PYHIN1_ENST00000392252.3_Missense_Mutation_p.Q390L|PYHIN1_ENST00000392254.2_Missense_Mutation_p.Q399L	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	399	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					TTTCAGATACAGAAAAATACA	0.358000													14	19					0	0	0.020292	0	0
MC4R	4160	broad.mit.edu	37	18	58039571	58039571	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:58039571G>A	ENST00000299766.3	-	1	430	c.12C>T	c.(10-12)tcC>tcT	p.S4S		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	4					feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				CACGGTGGGTGGAGTTCACCA	0.517000													16	50					0	0	0.007413	0	0
GZF1	64412	broad.mit.edu	37	20	23345107	23345107	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:23345107C>T	ENST00000338121.5	+	2	164	c.87C>T	c.(85-87)caC>caT	p.H29H	GZF1_ENST00000377051.2_Silent_p.H29H|GZF1_ENST00000542987.1_Intron|GZF1_ENST00000544236.1_Intron			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	29					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TCCTGGGTCACCTGTGTGACG	0.522000													10	18					0	0	0.013537	0	0
NRIP1	8204	broad.mit.edu	37	21	16339226	16339226	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:16339226C>A	ENST00000400202.1	-	3	2000	c.1288G>T	c.(1288-1290)Ggt>Tgt	p.G430C	NRIP1_ENST00000318948.4_Missense_Mutation_p.G430C|NRIP1_ENST00000400199.1_Missense_Mutation_p.G430C			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	430	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity	p.G430C(1)		cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CTTTCATCACCACTGCTGTCA	0.388000													18	78					1.01871e-10	1.47352e-10	0.008871	1	0
ZNF547	284306	broad.mit.edu	37	19	57889018	57889018	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:57889018C>G	ENST00000282282.3	+	4	824	c.674C>G	c.(673-675)tCt>tGt	p.S225C	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTTGTAAGTCTCACCTTGTT	0.428000													45	54					0	0	0.014410	0	0
MYO19	80179	broad.mit.edu	37	17	34863706	34863706	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:34863706C>G	ENST00000431794.3	-	15	1811	c.1289G>C	c.(1288-1290)tGc>tCc	p.C430S	MYO19_ENST00000268852.9_Missense_Mutation_p.C430S	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	430	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GTAGTTGATGCACAACTGTTC	0.542000													4	16					0	0	0.014758	0	0
COL1A1	1277	broad.mit.edu	37	17	48277195	48277195	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:48277195C>T	ENST00000225964.5	-	2	335	c.217G>A	c.(217-219)Gtg>Atg	p.V73M		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	73	VWFC.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	TCACAGATCACGTCATCGCAC	0.662000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						41	154					0	0	0.014410	0	0
RUVBL2	10856	broad.mit.edu	37	19	49506546	49506546	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:49506546C>G	ENST00000595090.1	+	3	542	c.78C>G	c.(76-78)tcC>tcG	p.S26S	RUVBL2_ENST00000601968.1_5'UTR|RUVBL2_ENST00000413176.2_5'UTR	NM_006666.1	NP_006657.1	Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	26					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GTGCCCACTCCCACATCCGGG	0.582000													9	14					0	0	0.008291	0	0
DNAH7	56171	broad.mit.edu	37	2	196913077	196913077	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:196913077C>A	ENST00000312428.6	-	4	293	c.193G>T	c.(193-195)Gta>Tta	p.V65L	DNAH7_ENST00000410072.1_Missense_Mutation_p.V65L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	65	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCTGCTTTACACTCAAATGG	0.338000													11	52					3.07112e-06	3.80316e-06	0.010729	1	0
TSPAN6	7105	broad.mit.edu	37	X	99890233	99890233	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:99890233G>T	ENST00000373020.4	-	3	404	c.293C>A	c.(292-294)aCt>aAt	p.T98N	TSPAN6_ENST00000496771.1_5'UTR	NM_003270.2	NP_003261.1	O43657	TSN6_HUMAN	tetraspanin 6	98					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|ovary(1)	12						AAAAACGAGAGTCAGAAACAT	0.393000													9	23					7.03913e-09	9.56711e-09	0.013537	1	0
COL9A3	1299	broad.mit.edu	37	20	61468464	61468464	+	Silent	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:61468464A>C	ENST00000343916.3	+	30	1636	c.1633A>C	c.(1633-1635)Agg>Cgg	p.R545R	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	545	Nonhelical region 3 (NC3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					CGCGCACCTAAGGAAGCCTTT	0.582000													21	37					0	0	0.009535	0	0
SYTL4	94121	broad.mit.edu	37	X	99933578	99933578	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:99933578C>A	ENST00000455616.1	-	17	2023	c.1677G>T	c.(1675-1677)agG>agT	p.R559S	SYTL4_ENST00000454200.2_Missense_Mutation_p.R561S|SYTL4_ENST00000276141.6_Missense_Mutation_p.R559S|SYTL4_ENST00000491602.1_5'UTR|SYTL4_ENST00000263033.5_Missense_Mutation_p.R559S|SYTL4_ENST00000372989.1_Missense_Mutation_p.R559S			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	559	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGCCTTGTTCCTCATGGGAA	0.483000													63	173					2.36135e-34	4.36478e-34	0.014410	1	0
MYH1	4619	broad.mit.edu	37	17	10406525	10406525	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:10406525T>A	ENST00000226207.5	-	23	2826	c.2732A>T	c.(2731-2733)cAg>cTg	p.Q911L	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	911						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTTGATTAGCTGGTCACACCT	0.413000													16	28					0	0	0.004656	0	0
EXD2	55218	broad.mit.edu	37	14	69702849	69702849	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:69702849A>G	ENST00000409014.1	+	8	1418	c.761A>G	c.(760-762)tAc>tGc	p.Y254C	EXD2_ENST00000409949.1_Missense_Mutation_p.Y254C|EXD2_ENST00000312994.5_Missense_Mutation_p.Y379C|EXD2_ENST00000409675.1_Missense_Mutation_p.Y254C|EXD2_ENST00000409242.1_Missense_Mutation_p.Y254C|EXD2_ENST00000409018.3_Missense_Mutation_p.Y379C|EXD2_ENST00000449989.1_Missense_Mutation_p.Y254C|EXD2_ENST00000492815.1_3'UTR	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	254					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						GCTCAGTGGTACCTGGACAAA	0.463000													18	64					0	0	0.018920	0	0
LCT	3938	broad.mit.edu	37	2	136561677	136561677	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:136561677G>C	ENST00000264162.2	-	11	4496	c.4486C>G	c.(4486-4488)Cta>Gta	p.L1496V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1496	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTCTGTGGTAGGTCCCAGTGG	0.527000													13	30					0	0	0.020292	0	0
TENM2	57451	broad.mit.edu	37	5	167625938	167625938	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:167625938T>A	ENST00000519204.1	+	15	2736	c.2618T>A	c.(2617-2619)gTg>gAg	p.V873E	TENM2_ENST00000520394.1_Missense_Mutation_p.V762E|TENM2_ENST00000518659.1_Missense_Mutation_p.V994E|TENM2_ENST00000403607.2_Missense_Mutation_p.V818E|TENM2_ENST00000545108.1_Missense_Mutation_p.V994E					teneurin transmembrane protein 2																		GAGCGCACTGTGTGGCTGCCG	0.567000													13	31					0	0	0.010504	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063772	247063772	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:247063772C>A	ENST00000366508.1	-	9	1359		c.e9-1		AHCTF1_ENST00000391829.2_Splice_Site|AHCTF1_ENST00000326225.3_Splice_Site			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1						cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GGCGATAGAGCTGGAAGAAAA	0.333000													14	27					3.52763e-06	4.35009e-06	0.004990	1	0
OR6C65	403282	broad.mit.edu	37	12	55794780	55794780	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:55794780C>A	ENST00000379665.2	+	1	567	c.468C>A	c.(466-468)ccC>ccA	p.P156P		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TTATTTTTCCCCCCGTGATTA	0.433000													15	47					1.01871e-10	1.47352e-10	0.008871	1	0
FLNC	2318	broad.mit.edu	37	7	128482421	128482421	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:128482421C>G	ENST00000325888.8	+	14	2519	c.2258C>G	c.(2257-2259)cCc>cGc	p.P753R	FLNC_ENST00000346177.6_Missense_Mutation_p.P753R	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	753					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCCAAGAGCCCCTTCCGGGTG	0.677000											OREG0018297	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0	0	0.001168	0	0
NACA2	342538	broad.mit.edu	37	17	59668401	59668401	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:59668401G>T	ENST00000521764.1	-	1	162	c.141C>A	c.(139-141)acC>acA	p.T47T		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	47					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CTTTTTGTGTGGTGGTCTGGG	0.517000													16	45					7.63091e-17	1.23615e-16	0.007835	1	0
ZNF665	79788	broad.mit.edu	37	19	53669522	53669522	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:53669522T>G	ENST00000600412.1	-	2	141	c.26A>C	c.(25-27)aAg>aCg	p.K9T	ZNF665_ENST00000396424.3_Missense_Mutation_p.K74T			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TCTCTCCAACTTCACCGTGTA	0.408000													30	84					0	0	0.007835	0	0
AMOT	154796	broad.mit.edu	37	X	112022251	112022251	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:112022251C>G	ENST00000371959.3	-	10	3130	c.3131G>C	c.(3130-3132)aGt>aCt	p.S1044T	AMOT_ENST00000524145.1_Missense_Mutation_p.S1044T|AMOT_ENST00000371962.1_Missense_Mutation_p.S812T|AMOT_ENST00000304758.1_Missense_Mutation_p.S635T	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	1044					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GCAGGTCAAACTTGGTATAGA	0.463000													21	291					0	0	0.005443	0	0
NKTR	4820	broad.mit.edu	37	3	42680803	42680803	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:42680803A>T	ENST00000232978.8	+	13	3795	c.3607A>T	c.(3607-3609)Agt>Tgt	p.S1203C	RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1203					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TAGCTTGGCTAGTGCTGGAGA	0.512000													10	17					0	0	0.004990	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140306846	140306846	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140306846C>T	ENST00000253807.2	+	1	369	c.369C>T	c.(367-369)ctC>ctT	p.L123L	PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHAC1_ENST00000409700.3_Silent_p.L123L|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCACCTCTCTTTCCTGCCG	0.597000													6	41					0	0	0.003163	0	0
SUN3	256979	broad.mit.edu	37	7	48046872	48046872	+	Nonsense_Mutation	SNP	C	C	A	rs145833872		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:48046872C>A	ENST00000453192.2	-	6	589	c.346G>T	c.(346-348)Gaa>Taa	p.E116*	SUN3_ENST00000297325.4_Nonsense_Mutation_p.E128*|SUN3_ENST00000395572.2_Nonsense_Mutation_p.E128*|SUN3_ENST00000412142.1_Nonsense_Mutation_p.E28*			Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	128						integral to membrane		p.E128K(2)		central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCTATTTGTTCGATCAAAAAT	0.418000													9	32					0.00621372	0.00654154	0.006214	1	0
ZNF521	25925	broad.mit.edu	37	18	22805974	22805974	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:22805974A>C	ENST00000361524.3	-	4	2056	c.1908T>G	c.(1906-1908)tgT>tgG	p.C636W	ZNF521_ENST00000584787.1_Missense_Mutation_p.C416W|ZNF521_ENST00000538137.2_Missense_Mutation_p.C636W	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	636					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CACATTGATTACAGATATATT	0.478000			T	PAX5	ALL								49	79					0	0	0.014410	0	0
NEB	4703	broad.mit.edu	37	2	152467372	152467372	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:152467372G>T	ENST00000397345.3	-	79	12016	c.11814C>A	c.(11812-11814)taC>taA	p.Y3938*	NEB_ENST00000603639.1_Nonsense_Mutation_p.Y3938*|NEB_ENST00000172853.10_Nonsense_Mutation_p.Y3695*|NEB_ENST00000604864.1_Nonsense_Mutation_p.Y3938*|NEB_ENST00000427231.2_Nonsense_Mutation_p.Y3938*|NEB_ENST00000409198.1_Nonsense_Mutation_p.Y3695*	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	3938					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAGCTTCTGTGTATAAATGCT	0.478000													5	15					0.000602214	0.000662587	0.014758	1	0
SULT2A1	6822	broad.mit.edu	37	19	48385427	48385427	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:48385427G>T	ENST00000222002.3	-	3	525	c.386C>A	c.(385-387)tCt>tAt	p.S129Y		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	129					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		AAAATAACCAGACACCAAAAC	0.338000													36	47					9.9191e-30	1.78097e-29	0.008740	1	0
FUT9	10690	broad.mit.edu	37	6	96651790	96651790	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:96651790C>A	ENST00000302103.5	+	3	1085	c.759C>A	c.(757-759)atC>atA	p.I253I		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	253					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AGGATTACATCACGGAAAAGC	0.343000													7	19					0.000157383	0.000179691	0.003080	1	0
TBC1D8B	54885	broad.mit.edu	37	X	106093413	106093413	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:106093413G>T	ENST00000357242.5	+	12	2170	c.1996G>T	c.(1996-1998)Gtg>Ttg	p.V666L	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.V660L	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	666	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGCAGTGAATGTGGTGGACTG	0.373000													62	113					3.39796e-24	5.9549e-24	0.014410	1	0
LRP1B	53353	broad.mit.edu	37	2	141215061	141215061	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:141215061T>A	ENST00000389484.3	-	61	10756	c.9785A>T	c.(9784-9786)cAg>cTg	p.Q3262L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3262					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGATACACCTGGATATCTGT	0.383000										TSP Lung(27;0.18)			19	54					0	0	0.008871	0	0
OR4N2	390429	broad.mit.edu	37	14	20295777	20295777	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:20295777C>A	ENST00000568211.1	+	1	170	c.170C>A	c.(169-171)gCc>gAc	p.A57D	OR4N2_ENST00000315947.1_Missense_Mutation_p.A57D			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGGCTCACAGCCCCCCTCTAT	0.478000													70	86					1.61229e-46	3.04428e-46	0.014410	1	0
OR52B2	255725	broad.mit.edu	37	11	6191551	6191551	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:6191551A>C	ENST00000530810.1	-	1	87	c.6T>G	c.(4-6)agT>agG	p.S2R	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTGGTGTGACTCATGATGC	0.418000													31	60					0	0	0.013726	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64747992	64747992	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:64747992C>G	ENST00000536360.1	-	6	1708	c.895G>C	c.(895-897)Gtg>Ctg	p.V299L				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	299	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AAGCGGGCCACTATAATATTC	0.348000													4	35					0	0	0.003080	0	0
SLC1A3	6507	broad.mit.edu	37	5	36671276	36671276	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:36671276G>T	ENST00000265113.4	+	4	941	c.465G>T	c.(463-465)atG>atT	p.M155I	CTD-2353F22.1_ENST00000510740.1_RNA|SLC1A3_ENST00000381918.3_Missense_Mutation_p.M155I	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	155					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	AGGAAAACATGCACAGAGAAG	0.468000													11	47					2.32078e-09	3.21396e-09	0.003163	1	0
NCAN	1463	broad.mit.edu	37	19	19338219	19338219	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:19338219C>T	ENST00000252575.5	+	8	1833	c.1790C>T	c.(1789-1791)cCa>cTa	p.P597L	NCAN_ENST00000538881.1_Missense_Mutation_p.P48L	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	597					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			AGTGCCAGGCCAGCCACCCCA	0.677000													4	5					0	0	0.001984	0	0
PRG4	10216	broad.mit.edu	37	1	186270774	186270774	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:186270774T>A	ENST00000445192.2	+	4	295	c.250T>A	c.(250-252)Tgt>Agt	p.C84S	PRG4_ENST00000367486.3_Missense_Mutation_p.C84S|PRG4_ENST00000367485.4_Missense_Mutation_p.C84S|PRG4_ENST00000367484.3_Missense_Mutation_p.C43S|PRG4_ENST00000367483.4_Missense_Mutation_p.C43S	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	84	SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AGGGAGGGAGTGTGACTGCGA	0.478000													8	28					0	0	0.013537	0	0
ANAPC7	51434	broad.mit.edu	37	12	110815423	110815423	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:110815423C>A	ENST00000455511.3	-	9	1235		c.e9-1		ANAPC7_ENST00000481473.1_Splice_Site|ANAPC7_ENST00000450008.2_Splice_Site	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						TCGATAAGACCTGAAAAAAGT	0.413000													8	31					0.00829132	0.00869746	0.008291	1	0
FAM46D	169966	broad.mit.edu	37	X	79698091	79698091	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:79698091A>T	ENST00000538312.1	+	5	387	c.53A>T	c.(52-54)gAt>gTt	p.D18V	FAM46D_ENST00000308293.5_Missense_Mutation_p.D18V	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	18										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						ATAACACTGGATCAAGTGTTA	0.368000													14	8					0	0	0.016723	0	0
ANKZF1	55139	broad.mit.edu	37	2	220100211	220100211	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:220100211G>T	ENST00000323348.5	+	11	1881	c.1707G>T	c.(1705-1707)cgG>cgT	p.R569R	ANKZF1_ENST00000409849.1_Silent_p.R359R|ANKZF1_ENST00000410034.3_Silent_p.R569R	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	569			R -> W (in dbSNP:rs2293076).			intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCGGGCCCGGCCACCTTATA	0.488000													15	34					6.44725e-10	9.13014e-10	0.014323	1	0
AGBL1	123624	broad.mit.edu	37	15	86697741	86697741	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:86697741G>T	ENST00000441037.2	+	3	300	c.205G>T	c.(205-207)Ggc>Tgc	p.G69C	AGBL1_ENST00000421325.2_Missense_Mutation_p.G69C	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	69					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CCTATCCCATGGCCAGAATCT	0.493000													12	31					1.5842e-08	2.14319e-08	0.016723	1	0
EXPH5	23086	broad.mit.edu	37	11	108381450	108381450	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:108381450A>C	ENST00000265843.4	-	6	4894	c.4784T>G	c.(4783-4785)tTg>tGg	p.L1595W	EXPH5_ENST00000525344.1_Missense_Mutation_p.L1588W|EXPH5_ENST00000428840.1_Missense_Mutation_p.L1519W|EXPH5_ENST00000443411.1_Missense_Mutation_p.L1407W	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1595					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CATGGCTGCCAATCTGTGTTT	0.433000													5	44					0	0	0.001168	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26423424	26423424	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:26423424G>T	ENST00000466808.2	+	0	343																											CAATGTCACAGCCGAGGATAA	0.542000													19	22					9.90768e-06	1.19164e-05	0.004656	1	0
GAPVD1	26130	broad.mit.edu	37	9	128122825	128122825	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:128122825C>T	ENST00000470056.1	+	24	4142	c.3982C>T	c.(3982-3984)Cca>Tca	p.P1328S	GAPVD1_ENST00000297933.6_Missense_Mutation_p.P1355S|GAPVD1_ENST00000265956.4_Missense_Mutation_p.P1347S|GAPVD1_ENST00000394104.2_Missense_Mutation_p.P1373S|GAPVD1_ENST00000394083.2_Missense_Mutation_p.P1307S|GAPVD1_ENST00000495955.1_Missense_Mutation_p.P1373S|GAPVD1_ENST00000312123.9_Missense_Mutation_p.P1334S|GAPVD1_ENST00000394105.2_Missense_Mutation_p.P1382S			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1373					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TCGAGAAGCACCATGGCCATC	0.463000													6	30					0	0	0.001984	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144912277	144912277	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:144912277C>A	ENST00000529945.1	-	11	2926	c.2487G>T	c.(2485-2487)ttG>ttT	p.L829F	PDE4DIP_ENST00000369359.4_Missense_Mutation_p.L803F|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.L829F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.L666F|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.L453F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.L803F|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.L666F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.L666F|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.L666F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.L732F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	666					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGCTTGCACCAACTTCTCTG	0.388000			T	PDGFRB	MPD								9	49					0.00829132	0.00869746	0.008291	1	0
NFKBIA	4792	broad.mit.edu	37	14	35871818	35871818	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:35871818G>C	ENST00000216797.5	-	5	789	c.688C>G	c.(688-690)Cct>Gct	p.P230A	NFKBIA_ENST00000557389.1_Missense_Mutation_p.P140A|NFKBIA_ENST00000557100.1_5'UTR|NFKBIA_ENST00000557140.1_Intron	NM_020529.2	NP_065390.1	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	230					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(3)|endometrium(1)|large_intestine(2)|liver(1)	7	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		ACCAGGTCAGGATTTTGCAGG	0.532000													8	32					0	0	0.006214	0	0
ZNF496	84838	broad.mit.edu	37	1	247473695	247473695	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:247473695C>A	ENST00000294753.4	-	6	1179	c.715G>T	c.(715-717)Gat>Tat	p.D239Y	ZNF496_ENST00000366498.2_Missense_Mutation_p.D275Y|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	239	KRAB.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGGGCAGGATCTAGAAGGGAC	0.502000													10	40					5.35356e-11	7.79506e-11	0.016522	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303812	151303812	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:151303812G>T	ENST00000370323.4	-	4	597	c.281C>A	c.(280-282)cCc>cAc	p.P94H	MAGEA10_ENST00000244096.3_Missense_Mutation_p.P94H|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	94										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AACGACCGAGGGGGAGGAGCA	0.547000													45	110					4.01344e-20	6.82907e-20	0.014410	1	0
TARSL2	123283	broad.mit.edu	37	15	102242441	102242441	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:102242441C>A	ENST00000335968.3	-	9	1438		c.e9+1			NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2						threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGGGGCATACCTTCCCGATC	0.388000													11	68					0.000673444	0.000733603	0.008291	1	0
TTN	7273	broad.mit.edu	37	2	179434377	179434377	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179434377G>A	ENST00000589042.1	-	326	76706	c.76482C>T	c.(76480-76482)gaC>gaT	p.D25494D	TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Silent_p.D16621D|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.D16554D|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Silent_p.D22926D|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Silent_p.D23853D|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Silent_p.D16429D|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23853	Fibronectin type-III 85.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCAGGGACGTCAGCATGTT	0.373000													6	14					0	0	0.001984	0	0
SLC12A1	6557	broad.mit.edu	37	15	48519296	48519296	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:48519296G>T	ENST00000396577.3	+	5	864	c.649G>T	c.(649-651)Ggc>Tgc	p.G217C	SLC12A1_ENST00000558405.1_Intron|SLC12A1_ENST00000380993.3_Intron|SLC12A1_ENST00000559723.1_Intron|SLC12A1_ENST00000330289.6_Intron	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	217					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CATCATCATTGGCCTAAGTGT	0.438000													15	19					0.000422831	0.000471723	0.004007	1	0
SARM1	23098	broad.mit.edu	37	17	26711501	26711501	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:26711501C>A	ENST00000457710.3	+	3	1584	c.1113C>A	c.(1111-1113)atC>atA	p.I371I	SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	405					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CACGGCCCATCCTGCCCTCCG	0.642000													5	10					0.00136819	0.00147758	0.013537	1	0
HIST1H3E	8353	broad.mit.edu	37	6	26225652	26225652	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:26225652G>A	ENST00000360408.1	+	1	270	c.270G>A	c.(268-270)gtG>gtA	p.V90V		NM_003532.2	NP_003523.1	P68431	H31_HUMAN	histone cluster 1, H3e	90					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(5)|skin(1)	8		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GTTCCGCGGTGATGGCGCTGC	0.577000											OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	28					0	0	0.007835	0	0
KANSL1	284058	broad.mit.edu	37	17	44127970	44127970	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:44127970T>A	ENST00000262419.6	-	7	2419	c.1949A>T	c.(1948-1950)tAt>tTt	p.Y650F	KANSL1_ENST00000432791.1_Missense_Mutation_p.Y650F|KANSL1_ENST00000393476.3_Missense_Mutation_p.Y7F|KANSL1_ENST00000575318.1_Missense_Mutation_p.Y650F|KANSL1_ENST00000574590.1_Missense_Mutation_p.Y650F|KANSL1_ENST00000572904.1_Missense_Mutation_p.Y650F	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	650						MLL1 complex	protein binding										AGGGGCTTCATAGTGAATTTC	0.502000													16	50					0	0	0.004990	0	0
SCAMP3	10067	broad.mit.edu	37	1	155228745	155228745	+	Splice_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:155228745G>A	ENST00000355379.3	-	4	589	c.310_splice	c.e4-1	p.T104_splice	SCAMP3_ENST00000302631.3_Splice_Site_p.T130_splice|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	130					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTTCTGTCGAGCTGTAAGGCA	0.468000													7	231					0	0	0.004482	0	0
CD86	942	broad.mit.edu	37	3	121828231	121828231	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:121828231C>A	ENST00000330540.2	+	5	939	c.823C>A	c.(823-825)Cgg>Agg	p.R275R	CD86_ENST00000264468.5_Silent_p.R62R|CD86_ENST00000469710.1_Silent_p.R193R|CD86_ENST00000393627.2_Silent_p.R269R|CD86_ENST00000493101.1_Silent_p.R163R	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	275					interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	GAAGAAGAAGCGGCCTCGCAA	0.473000													33	85					4.14481e-20	7.02537e-20	0.006230	1	0
CCDC39	339829	broad.mit.edu	37	3	180381730	180381730	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:180381730T>G	ENST00000273654.4	-	8	1006	c.387A>C	c.(385-387)ttA>ttC	p.L129F	CCDC39_ENST00000442201.2_Missense_Mutation_p.L45F			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	45					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CATACTCACGTAACTCATCTT	0.323000													12	31					0	0	0.020292	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542605	133542605	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:133542605T>C	ENST00000409261.1	-	14	2152	c.1779A>G	c.(1777-1779)atA>atG	p.I593M	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.I593M	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	593							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CACTGCTCTCTATGTGCAGCT	0.532000													13	35					0	0	0.008871	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736948	140736948	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140736948T>A	ENST00000571252.1	+	1	2181	c.2181T>A	c.(2179-2181)gcT>gcA	p.A727A	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTTCACGCTGAAGGCAGCA	0.622000													4	11					0	0	0.001984	0	0
OSBPL8	114882	broad.mit.edu	37	12	76769070	76769070	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:76769070G>C	ENST00000261183.3	-	17	2289	c.1810C>G	c.(1810-1812)Ctt>Gtt	p.L604V	OSBPL8_ENST00000393249.2_Missense_Mutation_p.L562V|OSBPL8_ENST00000393250.4_Missense_Mutation_p.L562V	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	604					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TTAAATTCAAGTATTGCACTG	0.343000													9	22					0	0	0.006214	0	0
C6orf118	168090	broad.mit.edu	37	6	165703510	165703510	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:165703510A>T	ENST00000230301.8	-	7	1187	c.1167T>A	c.(1165-1167)acT>acA	p.T389T	C6orf118_ENST00000543069.1_3'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	389										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CAACCTTCTCAGTAAGAGTAA	0.299000													10	17					0	0	0.016723	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24953396	24953396	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:24953396T>A	ENST00000289968.6	-	16	1471	c.1402A>T	c.(1402-1404)Act>Tct	p.T468S	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Missense_Mutation_p.T468S	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	468					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		TCGTTTCCAGTGTGGAATGAG	0.478000													33	63					0	0	0.006230	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994748	45994748	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:45994748C>A	ENST00000400374.3	+	1	1143	c.1113C>A	c.(1111-1113)ccC>ccA	p.P371P	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	371	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						TGTGCAGGCCCGCCTGCTGCG	0.697000													10	21					6.21321e-17	1.00835e-16	0.016522	1	0
NWD1	284434	broad.mit.edu	37	19	16925862	16925862	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:16925862G>T	ENST00000552788.1	+	18	4417	c.4417G>T	c.(4417-4419)Gtc>Ttc	p.V1473F	NWD1_ENST00000549814.1_Missense_Mutation_p.V1431F|NWD1_ENST00000523826.1_Missense_Mutation_p.V1267F|NWD1_ENST00000524140.2_3'UTR|NWD1_ENST00000379808.3_3'UTR|NWD1_ENST00000339803.6_Missense_Mutation_p.V1338F			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1473							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGTCCAGTTTGTCCATGCTGT	0.498000													15	15					3.32936e-07	4.26741e-07	0.006122	1	0
ZNF572	137209	broad.mit.edu	37	8	125989914	125989914	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:125989914C>A	ENST00000319286.5	+	3	1558	c.1404C>A	c.(1402-1404)taC>taA	p.Y468*		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AAAAACCTTACAAATGTACCA	0.468000										HNSCC(60;0.17)			8	244					2.80697e-09	3.86289e-09	0.010729	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74506933	74506933	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:74506933T>C	ENST00000354431.4	-	7	1873	c.1682A>G	c.(1681-1683)tAt>tGt	p.Y561C	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.Y561C	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	561										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						ATTCTTTCTATATTTTTCTGC	0.308000													33	49					0	0	0.015359	0	0
RBM43	375287	broad.mit.edu	37	2	152107565	152107565	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:152107565T>C	ENST00000331426.5	-	4	1080	c.929A>G	c.(928-930)aAa>aGa	p.K310R		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	310							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		ACATGCCCTTTTGATCATTCT	0.353000													27	66					0	0	0.008361	0	0
NID1	4811	broad.mit.edu	37	1	236193008	236193008	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:236193008T>G	ENST00000264187.6	-	7	1662	c.1580A>C	c.(1579-1581)cAc>cCc	p.H527P	NID1_ENST00000366595.3_Missense_Mutation_p.H527P	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	527	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	ATTGCCCGGGTGCCCCACGAA	0.622000													3	13					0	0	0.009096	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596921	142596921	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:142596921G>T	ENST00000370503.2	-	2	232	c.149C>A	c.(148-150)cCa>cAa	p.P50Q	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	50										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					AAATATTATTGGATATTCTGA	0.388000													191	505					2.78823e-73	5.31034e-73	0.014410	1	0
MST1L	11223	broad.mit.edu	37	1	17083652	17083652	+	RNA	SNP	C	C	T	rs113710576	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:17083652C>T	ENST00000455405.2	-	0	936																											aaatctcaaccttgagtacaa	0.388000													4	63					0	0	0.001984	0	0
ADCY2	108	broad.mit.edu	37	5	7626395	7626395	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:7626395C>A	ENST00000338316.4	+	4	775	c.686C>A	c.(685-687)tCg>tAg	p.S229*		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	229					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGCATCAAGTCGCGGATCAAG	0.393000													11	35					3.27435e-08	4.36912e-08	0.020292	1	0
RIMS3	9783	broad.mit.edu	37	1	41107561	41107561	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:41107561C>A	ENST00000372684.3	-	3	506	c.37G>T	c.(37-39)Gcc>Tcc	p.A13S	RIMS3_ENST00000372683.1_Missense_Mutation_p.A13S	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	13					neurotransmitter transport	cell junction|synapse				NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			TTCCTGGAGGCCCCAGATGAG	0.642000													4	28					0.00116845	0.00126498	0.001168	1	0
SLC20A2	6575	broad.mit.edu	37	8	42302219	42302219	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:42302219C>G	ENST00000342228.3	-	6	1044	c.675G>C	c.(673-675)ctG>ctC	p.L225L	SLC20A2_ENST00000520179.1_Silent_p.L225L|SLC20A2_ENST00000520262.1_Silent_p.L225L	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	225					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAAAAGCGAACAGGAGGGCGA	0.483000													18	17					0	0	0.007413	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140763581	140763581	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140763581A>G	ENST00000518325.1	+	1	1115	c.1115A>G	c.(1114-1116)cAa>cGa	p.Q372R	PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTACCTACAAGACAGAGAT	0.378000													4	9					0	0	0.014758	0	0
OR1L6	392390	broad.mit.edu	37	9	125512435	125512435	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:125512435C>A	ENST00000373684.1	+	1	417	c.417C>A	c.(415-417)taC>taA	p.Y139*	OR1L6_ENST00000304720.2_Nonsense_Mutation_p.Y103*			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CCCAGATGTACTTCTTTATGG	0.488000													25	49					1.30897e-18	2.18494e-18	0.009535	1	0
SMIM7	79086	broad.mit.edu	37	19	16764924	16764924	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:16764924C>A	ENST00000487416.2	-	4	180	c.134G>T	c.(133-135)cGg>cTg	p.R45L	SMIM7_ENST00000397349.2_5'UTR|SMIM7_ENST00000358726.6_Missense_Mutation_p.R45L|SMIM7_ENST00000597711.1_Intron|CTC-429P9.4_ENST00000600705.1_Intron|CTC-429P9.4_ENST00000593962.1_5'UTR	NM_024104.3	NP_077009.2			small integral membrane protein 7																		CAAGAATTCCCGGATGTTGTC	0.483000													10	30					2.68362e-12	4.04154e-12	0.013537	1	0
WNT7A	7476	broad.mit.edu	37	3	13860878	13860878	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:13860878C>A	ENST00000285018.4	-	4	917	c.613G>T	c.(613-615)Gtg>Ttg	p.V205L		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	205					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						GAGCCTGACACGCCGTGGCAC	0.602000													10	33					5.03518e-11	7.35589e-11	0.007413	1	0
PRRC1	133619	broad.mit.edu	37	5	126860319	126860319	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:126860319G>C	ENST00000442138.2	+	3	346	c.200G>C	c.(199-201)aGg>aCg	p.R67T	PRRC1_ENST00000512635.2_Missense_Mutation_p.R67T|PRRC1_ENST00000296666.8_Missense_Mutation_p.R67T			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	67	Pro-rich.					Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		CCTCCTGTGAGGCCTTCAGCA	0.522000													21	99					0	0	0.004656	0	0
STON1	11037	broad.mit.edu	37	2	48807910	48807910	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:48807910C>A	ENST00000309835.3	+	1	148	c.138C>A	c.(136-138)ggC>ggA	p.G46G	STON1-GTF2A1L_ENST00000309827.2_Silent_p.G46G|STON1_ENST00000406226.1_Silent_p.G46G|STON1-GTF2A1L_ENST00000394751.3_Silent_p.G46G|STON1-GTF2A1L_ENST00000405008.1_Silent_p.G46G|STON1-GTF2A1L_ENST00000394754.1_Silent_p.G46G|STON1_ENST00000404752.1_Silent_p.G46G|STON1-GTF2A1L_ENST00000402114.2_Silent_p.G46G					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACCTTCCTGGCCTCAGGGAAT	0.463000													7	29					1.12685e-05	1.34609e-05	0.004482	1	0
IL2RG	3561	broad.mit.edu	37	X	70328489	70328489	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:70328489A>G	ENST00000374202.2	-	6	905	c.814T>C	c.(814-816)Ttg>Ctg	p.L272L	IL2RG_ENST00000456850.2_Silent_p.L82L|IL2RG_ENST00000374188.3_Intron	NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	272					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	CTGATAATCAATCCCATGGAG	0.443000									Severe Combined Immunodeficiency, X-linked				14	10					0	0	0.003163	0	0
IKZF1	10320	broad.mit.edu	37	7	50459442	50459442	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:50459442C>G	ENST00000331340.3	+	7	886	c.731C>G	c.(730-732)aCt>aGt	p.T244S	IKZF1_ENST00000349824.4_Intron|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000439701.1_Missense_Mutation_p.T202S|IKZF1_ENST00000343574.5_Missense_Mutation_p.T157S|IKZF1_ENST00000359197.5_Missense_Mutation_p.T202S|IKZF1_ENST00000440768.2_Missense_Mutation_p.T202S|IKZF1_ENST00000438033.1_Missense_Mutation_p.T157S|IKZF1_ENST00000357364.4_Intron	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	244					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AAAGAAGAAACTAATCACAGT	0.418000			"""D,T"""	BCL6	"""ALL, DLBCL"""								20	69					0	0	0.008361	0	0
PLTP	5360	broad.mit.edu	37	20	44540122	44540122	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:44540122G>T	ENST00000542937.1	-	1	564	c.30C>A	c.(28-30)tgC>tgA	p.C10*	PLTP_ENST00000420868.2_Intron|PLTP_ENST00000372431.3_Intron|PLTP_ENST00000354050.4_Intron|PLTP_ENST00000477313.1_5'UTR			P55058	PLTP_HUMAN	phospholipid transfer protein	0					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)	21		Myeloproliferative disorder(115;0.0122)				GGGTGGGGTCGCAGGAGTTAT	0.602000													3	17					0.00198382	0.00211897	0.001984	1	0
LPHN3	23284	broad.mit.edu	37	4	62933897	62933897	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:62933897G>T	ENST00000512091.1	+	25	4371	c.3624G>T	c.(3622-3624)gaG>gaT	p.E1208D	LPHN3_ENST00000514157.1_Missense_Mutation_p.E1242D|LPHN3_ENST00000508946.1_Intron|LPHN3_ENST00000511324.1_Missense_Mutation_p.E1267D|LPHN3_ENST00000504896.1_Missense_Mutation_p.E1251D|LPHN3_ENST00000514591.1_Intron|LPHN3_ENST00000508693.1_Missense_Mutation_p.E1319D|LPHN3_ENST00000545650.1_Intron|LPHN3_ENST00000509896.1_Missense_Mutation_p.E1276D|LPHN3_ENST00000506746.1_Intron|LPHN3_ENST00000514996.1_Intron|LPHN3_ENST00000507625.1_Intron|LPHN3_ENST00000507164.1_Missense_Mutation_p.E1310D|LPHN3_ENST00000506720.1_Intron|LPHN3_ENST00000506700.1_Missense_Mutation_p.E1199D			Q9HAR2	LPHN3_HUMAN	latrophilin 3	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCTACAGAGAGACAAGTATGG	0.318000													16	45					0.000422831	0.000471723	0.004007	1	0
LOC100507657	100507657	broad.mit.edu	37	22	27708279	27708279	+	RNA	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:27708279G>C	ENST00000426467.1	+	0	1668				CTA-929C8.7_ENST00000454387.1_lincRNA																							ggggcagagaggggaacaagg	0.463000													3	13					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179554576	179554576	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179554576G>T	ENST00000589042.1	-	122	32034	c.31810C>A	c.(31810-31812)Cct>Act	p.P10604T	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P9360T|TTN_ENST00000591111.1_Missense_Mutation_p.P10287T|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10287	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGCAACAGGAACGGGAATC	0.373000													39	106					1.62263e-30	2.94352e-30	0.014410	1	0
MROH8	140699	broad.mit.edu	37	20	35757453	35757453	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:35757453C>T	ENST00000400441.3	-	14	1766	c.1767G>A	c.(1765-1767)atG>atA	p.M589I	MROH8_ENST00000441008.2_Missense_Mutation_p.M575I|MROH8_ENST00000217333.8_Missense_Mutation_p.M418I					maestro heat-like repeat family member 8																		CCACATATGCCATCTTCTCCT	0.557000													7	55					0	0	0.013537	0	0
ADCY8	114	broad.mit.edu	37	8	131848681	131848681	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:131848681C>A	ENST00000286355.5	-	12	4609	c.2517G>T	c.(2515-2517)acG>acT	p.T839T	ADCY8_ENST00000377928.3_Silent_p.T708T	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	839					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCAACACCCCCGTGAAGACAA	0.532000										HNSCC(32;0.087)			20	73					9.95505e-16	1.58919e-15	0.014323	1	0
RNGTT	8732	broad.mit.edu	37	6	89324082	89324082	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:89324082T>A	ENST00000369485.4	-	15	1725	c.1539A>T	c.(1537-1539)aaA>aaT	p.K513N	RNGTT_ENST00000538899.1_Missense_Mutation_p.K430N|RNGTT_ENST00000265607.6_Missense_Mutation_p.K490N	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	513	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		ATTCTATAATTTTGTTGTCAT	0.358000													4	37					0	0	0.009096	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926395	157926395	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:157926395C>G	ENST00000389413.3	-	9	1633	c.1530G>C	c.(1528-1530)gcG>gcC	p.A510A	PTPRN2_ENST00000389416.4_Silent_p.A493A|PTPRN2_ENST00000389418.4_Silent_p.A510A|PTPRN2_ENST00000404321.2_Silent_p.A533A|PTPRN2_ENST00000409483.1_Silent_p.A472A	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	510						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.A510A(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGTAGCCCCGCGCCTCTTCCT	0.662000													3	4					0	0	0.014758	0	0
TMEM41B	440026	broad.mit.edu	37	11	9321227	9321227	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:9321227C>G	ENST00000528080.1	-	2	481	c.143G>C	c.(142-144)gGa>gCa	p.G48A	TMEM41B_ENST00000533723.1_Missense_Mutation_p.G48A|TMEM41B_ENST00000527813.1_Missense_Mutation_p.G48A	NM_015012.3	NP_055827.1	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B	48						integral to membrane				kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(2)	7				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		TCTTGCTGATCCAGCTTCTAC	0.318000													7	10					0	0	0.006214	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55250038	55250038	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:55250038T>C	ENST00000342376.3	+	1	59	c.28T>C	c.(28-30)Tgt>Cgt	p.C10R	KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Missense_Mutation_p.C10R	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		CAGCATGGTGTGTGTTGGTGA	0.612000											OREG0003673	type=REGULATORY REGION|Gene=KIR2DL3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	31	23					0	0	0.009718	0	0
REC8	9985	broad.mit.edu	37	14	24642162	24642162	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:24642162G>T	ENST00000311457.3	+	4	779	c.180G>T	c.(178-180)ctG>ctT	p.L60L	REC8_ENST00000559919.1_Silent_p.L60L			O95072	REC8_HUMAN	REC8 meiotic recombination protein	60					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(265;0.00839)		AGCCCGGCCTGCCGCGGCCCC	0.607000													9	17					3.86212e-05	4.50923e-05	0.008291	1	0
NPY1R	4886	broad.mit.edu	37	4	164247263	164247263	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:164247263C>G	ENST00000296533.2	-	2	975	c.444G>C	c.(442-444)tgG>tgC	p.W148C	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	148					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TATTTGGTCTCCACCCTCGAG	0.428000													18	53					0	0	0.012319	0	0
CSMD2	114784	broad.mit.edu	37	1	34190165	34190165	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:34190165C>A	ENST00000373381.4	-	18	3012	c.2836G>T	c.(2836-2838)Gag>Tag	p.E946*		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	906	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCTCACACTCCAGAGGCTCC	0.592000													10	12					7.45023e-12	1.11058e-11	0.010504	1	0
IGSF9B	22997	broad.mit.edu	37	11	133790155	133790155	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:133790155C>A	ENST00000321016.8	-	18	3695	c.3465G>T	c.(3463-3465)ccG>ccT	p.P1155P	IGSF9B_ENST00000533871.2_Silent_p.P1155P			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1155	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CGTGCGCCCCCGGCTCAGCCG	0.692000													4	3					0.000274275	0.00030716	0.004482	1	0
DOCK11	139818	broad.mit.edu	37	X	117775175	117775175	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:117775175C>A	ENST00000276204.6	+	39	4241	c.4167C>A	c.(4165-4167)gaC>gaA	p.D1389E	DOCK11_ENST00000276202.7_Missense_Mutation_p.D1389E			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1389					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CTGAAGCAGACATTTTCCACC	0.373000													13	45					2.27111e-07	2.9281e-07	0.013537	1	0
CD300C	10871	broad.mit.edu	37	17	72537795	72537795	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:72537795A>G	ENST00000330793.1	-	4	968	c.608T>C	c.(607-609)cTc>cCc	p.L203P		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	203					cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						GTTCACCCAGAGGACGGCACC	0.592000													28	64					0	0	0.010818	0	0
METAP1D	254042	broad.mit.edu	37	2	172926339	172926339	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:172926339A>G	ENST00000315796.4	+	2	541	c.154A>G	c.(154-156)Ata>Gta	p.I52V	METAP1D_ENST00000488581.1_3'UTR	NM_199227.1	NP_954697.1	Q6UB28	AMP1D_HUMAN	methionyl aminopeptidase type 1D (mitochondrial)	52					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity	p.I52V(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	8						TTCACACAGTATAGTTTTGCC	0.393000													31	88					0	0	0.021022	0	0
ETNPPL	64850	broad.mit.edu	37	4	109670458	109670458	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:109670458C>A	ENST00000296486.3	-	8	1017	c.863G>T	c.(862-864)tGt>tTt	p.C288F	ETNPPL_ENST00000411864.2_Missense_Mutation_p.C282F|ETNPPL_ENST00000510706.1_Missense_Mutation_p.C248F|ETNPPL_ENST00000512646.1_Missense_Mutation_p.C230F	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase																		TGTTACCACACATGCCACCGG	0.453000													9	26					0.000442599	0.000490659	0.006214	1	0
QKI	9444	broad.mit.edu	37	6	163983052	163983052	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:163983052G>T	ENST00000361752.3	+	5	1136	c.585G>T	c.(583-585)atG>atT	p.M195I	QKI_ENST00000361195.2_Missense_Mutation_p.M195I|QKI_ENST00000392127.2_Missense_Mutation_p.M195I|QKI_ENST00000275262.7_Missense_Mutation_p.M195I|QKI_ENST00000453779.2_Missense_Mutation_p.M195I|QKI_ENST00000424802.3_Missense_Mutation_p.M195I	NM_006775.2|NM_206853.2|NM_206854.2|NM_206855.2	NP_006766.1|NP_996735.1|NP_996736.1|NP_996737.1	Q96PU8	QKI_HUMAN	QKI, KH domain containing, RNA binding	195					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(5)|ovary(1)|prostate(3)|urinary_tract(2)	27		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGCAGCTGATGGAGCTTGCGA	0.438000													38	47					1.32136e-16	2.12872e-16	0.008740	1	0
KIAA0586	9786	broad.mit.edu	37	14	58917366	58917366	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:58917366G>A	ENST00000423743.3	+	9	1157	c.899G>A	c.(898-900)cGc>cAc	p.R300H	KIAA0586_ENST00000556134.1_Missense_Mutation_p.R329H|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Missense_Mutation_p.R397H|KIAA0586_ENST00000261244.5_Missense_Mutation_p.R344H	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	344										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCAGCACCTCGCAGATTTGCT	0.358000													8	25					0	0	0.003080	0	0
TACR3	6870	broad.mit.edu	37	4	104577477	104577477	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:104577477C>A	ENST00000304883.2	-	3	902	c.762G>T	c.(760-762)ctG>ctT	p.L254L		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	254						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AACAGTACACCAGTATAATGA	0.383000													20	62					3.5997e-14	5.60379e-14	0.014323	1	0
WDR16	146845	broad.mit.edu	37	17	9511513	9511513	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:9511513A>C	ENST00000352665.5	+	7	900	c.831A>C	c.(829-831)aaA>aaC	p.K277N	WDR16_ENST00000396219.3_Missense_Mutation_p.K209N|WDR16_ENST00000299764.5_Missense_Mutation_p.K287N	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	277						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						TCTTCTGTAAAAGCCCTGGCT	0.527000													6	15					0	0	0.006214	0	0
ST18	9705	broad.mit.edu	37	8	53025846	53025846	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:53025846A>G	ENST00000276480.7	-	26	3739	c.3056T>C	c.(3055-3057)aTg>aCg	p.M1019T		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	1019						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ATTGCTGTACATATCTGTGAG	0.443000													10	48					0	0	0.008291	0	0
LANCL3	347404	broad.mit.edu	37	X	37515063	37515063	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:37515063G>T	ENST00000378621.3	+	2	998	c.697_splice	c.e2+1	p.L232_splice	LANCL3_ENST00000378619.3_Splice_Site_p.L232_splice|TM4SF2_ENST00000465127.1_Intron	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	232							catalytic activity			lung(4)|pancreas(1)	5						CCGAATACTTGGGTAAGTGAA	0.418000													22	52					1.1804e-14	1.86066e-14	0.021523	1	0
C1orf74	148304	broad.mit.edu	37	1	209956795	209956795	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:209956795C>T	ENST00000294811.1	-	2	441	c.185G>A	c.(184-186)gGg>gAg	p.G62E		NM_152485.2	NP_689698.1	Q96LT6	CA074_HUMAN	chromosome 1 open reading frame 74	62										endometrium(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	15				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		CTCTGATGCCCCTGCACAGTT	0.557000													15	46					0	0	0.007413	0	0
USP4	7375	broad.mit.edu	37	3	49323555	49323555	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:49323555C>G	ENST00000351842.4	-	15	2043	c.2035G>C	c.(2035-2037)Gat>Cat	p.D679H	USP4_ENST00000265560.4_Missense_Mutation_p.D726H	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	726					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AGTTTTCCATCAGCTGCAAGT	0.418000													16	23					0	0	0.007413	0	0
PEX1	5189	broad.mit.edu	37	7	92136428	92136428	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:92136428G>A	ENST00000248633.4	-	10	1778	c.1683C>T	c.(1681-1683)tcC>tcT	p.S561S	PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000438045.1_Silent_p.S239S|PEX1_ENST00000428214.1_Silent_p.S561S	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	561					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			ATACGCCTAAGGAATTCACTC	0.428000													5	22					0	0	0.014758	0	0
VCP	7415	broad.mit.edu	37	9	35057457	35057457	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:35057457C>A	ENST00000358901.6	-	16	3126	c.2231G>T	c.(2230-2232)cGc>cTc	p.R744L		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	744					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GACAGAACGGCGCGCAAAGCG	0.512000													121	242					4.85366e-67	9.20413e-67	0.014410	1	0
SLC28A1	9154	broad.mit.edu	37	15	85488009	85488009	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:85488009G>T	ENST00000394573.1	+	18	1987	c.1785G>T	c.(1783-1785)ggG>ggT	p.G595G	SLC28A1_ENST00000286749.3_Silent_p.G595G|SLC28A1_ENST00000537216.1_Intron|SLC28A1_ENST00000538177.1_Silent_p.G429G|SLC28A1_ENST00000537624.1_Silent_p.G595G	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	595					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGCCCAGGGGGGCTGAAGTTG	0.602000													27	111					1.30988e-24	2.30938e-24	0.010818	1	0
ZFHX4	79776	broad.mit.edu	37	8	77761363	77761363	+	Splice_Site	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:77761363A>T	ENST00000521891.2	+	7	4092	c.3645_splice	c.e7+1	p.Q1215_splice	ZFHX4_ENST00000455469.2_Splice_Site_p.Q1170_splice|ZFHX4_ENST00000050961.6_Splice_Site_p.Q1170_splice|ZFHX4_ENST00000518282.1_Splice_Site_p.Q1189_splice	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1170						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGTCATGAACAGGTAAATACT	0.388000										HNSCC(33;0.089)			4	8					0	0	0.001168	0	0
ABCA1	19	broad.mit.edu	37	9	107602736	107602736	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:107602736C>A	ENST00000374736.3	-	9	1272	c.878G>T	c.(877-879)aGc>aTc	p.S293I		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	293					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGAGCTGGAGCTGTTCACATT	0.557000													19	42					8.13963e-23	1.40959e-22	0.008871	1	0
KRT5	3852	broad.mit.edu	37	12	52913845	52913845	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:52913845C>A	ENST00000252242.4	-	1	626	c.236G>T	c.(235-237)aGt>aTt	p.S79I		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	79	Gly-rich.|Head.		S -> R (in dbSNP:rs1065115).		epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGCCACCACTAGTGCTGAT	0.612000													11	33					3.01185e-09	4.13188e-09	0.021523	1	0
FCRL5	83416	broad.mit.edu	37	1	157494130	157494130	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:157494130G>C	ENST00000361835.3	-	10	2335	c.2178C>G	c.(2176-2178)tcC>tcG	p.S726S	FCRL5_ENST00000368191.3_Silent_p.S641S|FCRL5_ENST00000356953.4_Silent_p.S726S|FCRL5_ENST00000368190.3_Silent_p.S726S	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	726	Ig-like C2-type 7.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CTGCCTCACAGGAGTAGATTC	0.542000													12	40					0	0	0.004990	0	0
SEPT12	124404	broad.mit.edu	37	16	4836082	4836082	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:4836082G>A	ENST00000268231.8	-	3	454	c.191C>T	c.(190-192)aCg>aTg	p.T64M	SEPT12_ENST00000591861.1_5'UTR|SEPT12_ENST00000396693.5_Missense_Mutation_p.T64M	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	64					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GTTCACCATCGTGGACTTGCC	0.547000													3	6					0	0	0.014758	0	0
SETX	23064	broad.mit.edu	37	9	135144819	135144819	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:135144819C>A	ENST00000372169.2	-	26	7527	c.7345G>T	c.(7345-7347)Gaa>Taa	p.E2449*	SETX_ENST00000224140.5_Intron|SETX_ENST00000393220.1_Intron|SETX_ENST00000477049.1_Intron			Q7Z333	SETX_HUMAN	senataxin	2429					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TACTTGGGTTCTGGGCTGAAA	0.368000											OREG0019570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	33					0.00244969	0.0026134	0.020292	1	0
PKHD1	5314	broad.mit.edu	37	6	51774220	51774220	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:51774220C>A	ENST00000371117.3	-	40	6818	c.6543G>T	c.(6541-6543)agG>agT	p.R2181S	PKHD1_ENST00000340994.4_Missense_Mutation_p.R2181S	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2181					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTCCCATATCCCTGGATCCTA	0.478000													68	116					5.21738e-30	9.40629e-30	0.014410	1	0
ABCA13	154664	broad.mit.edu	37	7	48313592	48313592	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:48313592T>C	ENST00000435803.1	+	17	4353	c.4329T>C	c.(4327-4329)aaT>aaC	p.N1443N		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1443					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGGTGTTAAATATAAAAAAAC	0.274000													10	24					0	0	0.016723	0	0
ZNF536	9745	broad.mit.edu	37	19	31038849	31038849	+	Splice_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:31038849G>A	ENST00000355537.3	+	4	2470		c.e4-1			NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAATCTTGCAGGTGAGAAACC	0.463000													16	43					0	0	0.010504	0	0
OR2M3	127062	broad.mit.edu	37	1	248366457	248366457	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:248366457C>G	ENST00000456743.1	+	1	126	c.88C>G	c.(88-90)Ctg>Gtg	p.L30V		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTCTTCTTTCTGGTCCTGGC	0.522000													45	106					0	0	0.014410	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17697671	17697671	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:17697671C>T	ENST00000399080.2	-	1	2035	c.2012G>A	c.(2011-2013)aGt>aAt	p.S671N		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	671										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGTTGTCATACTGAAGGAATT	0.269000													4	25					0	0	0.001168	0	0
RYR2	6262	broad.mit.edu	37	1	237604629	237604629	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:237604629A>T	ENST00000366574.2	+	13	1333	c.1016A>T	c.(1015-1017)gAt>gTt	p.D339V	RYR2_ENST00000360064.6_Missense_Mutation_p.D337V|RYR2_ENST00000542537.1_Missense_Mutation_p.D323V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	339	MIR 4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAAAATTGGATGTAGGGGTG	0.373000													29	81					0	0	0.007291	0	0
FYB	2533	broad.mit.edu	37	5	39202016	39202016	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:39202016G>T	ENST00000351578.6	-	2	1237	c.1047C>A	c.(1045-1047)ccC>ccA	p.P349P	FYB_ENST00000515010.1_Silent_p.P349P|FYB_ENST00000505428.1_Silent_p.P349P|FYB_ENST00000512982.1_Silent_p.P349P|FYB_ENST00000540520.1_Silent_p.P359P	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	349	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P349P(3)|p.P359P(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			AGGTAAACAAGGGAGGCAATG	0.502000													24	57					6.00712e-18	9.95142e-18	0.012213	1	0
OR2A25	392138	broad.mit.edu	37	7	143772060	143772060	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:143772060T>C	ENST00000408898.2	+	1	786	c.748T>C	c.(748-750)Ttt>Ctt	p.F250L		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GGTTGGACTCTTTTATGGCAC	0.478000													30	95					0	0	0.015359	0	0
CCDC158	339965	broad.mit.edu	37	4	77247165	77247165	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:77247165C>G	ENST00000388914.3	-	22	3154	c.3002G>C	c.(3001-3003)aGt>aCt	p.S1001T		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1001	Ser-rich.									breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CACAGATGGACTTGCTAAAAG	0.363000													25	92					0	0	0.004656	0	0
CACNA1E	777	broad.mit.edu	37	1	181702006	181702006	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:181702006A>T	ENST00000526775.1	+	19	2892	c.2727A>T	c.(2725-2727)acA>acT	p.T909T	CACNA1E_ENST00000357570.5_Silent_p.T879T|CACNA1E_ENST00000367570.1_Silent_p.T928T|CACNA1E_ENST00000360108.3_Silent_p.T909T|CACNA1E_ENST00000358338.5_Silent_p.T860T|CACNA1E_ENST00000367567.4_Silent_p.T535T|CACNA1E_ENST00000367573.2_Silent_p.T928T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	928					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCGTCAGGACAGAAGGCAAGG	0.652000													23	54					0	0	0.013726	0	0
FBLN7	129804	broad.mit.edu	37	2	112922668	112922668	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:112922668C>T	ENST00000331203.2	+	3	597	c.326C>T	c.(325-327)cCt>cTt	p.P109L	FBLN7_ENST00000409667.3_Missense_Mutation_p.P109L|FBLN7_ENST00000409450.3_Missense_Mutation_p.P109L|FBLN7_ENST00000472377.1_3'UTR|FBLN7_ENST00000409903.1_Missense_Mutation_p.P109L	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	109	Sushi.				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						ACCTGCAACCCTGGGTTCCGG	0.577000													6	24					0	0	0.008291	0	0
GPR112	139378	broad.mit.edu	37	X	135431946	135431946	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:135431946T>A	ENST00000394143.1	+	6	6372	c.6081T>A	c.(6079-6081)ccT>ccA	p.P2027P	GPR112_ENST00000287534.4_Silent_p.P1964P|GPR112_ENST00000394141.1_Silent_p.P1822P|GPR112_ENST00000370652.1_Silent_p.P2027P|GPR112_ENST00000412101.1_Silent_p.P1822P	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2027					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTAATGCCCCTCATGTTATGA	0.453000													68	92					0	0	0.014410	0	0
DNAH11	8701	broad.mit.edu	37	7	21934524	21934524	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:21934524C>A	ENST00000328843.6	+	80	13008	c.12977C>A	c.(12976-12978)gCt>gAt	p.A4326D	DNAH11_ENST00000409508.3_Missense_Mutation_p.A4319D			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4326					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTATCTCCTGCTGTGGAAGCC	0.458000									Kartagener syndrome				36	78					3.4345e-17	5.61543e-17	0.011902	1	0
POSTN	10631	broad.mit.edu	37	13	38160333	38160333	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:38160333C>G	ENST00000379747.4	-	7	955	c.838G>C	c.(838-840)Gag>Cag	p.E280Q	POSTN_ENST00000379743.4_Missense_Mutation_p.E280Q|POSTN_ENST00000541481.1_Missense_Mutation_p.E280Q|POSTN_ENST00000541179.1_Missense_Mutation_p.E280Q|POSTN_ENST00000379742.4_Missense_Mutation_p.E280Q|POSTN_ENST00000379749.4_Missense_Mutation_p.E280Q	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	280	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GGAAGTTTCTCAAAAGCCTCA	0.483000													17	22					0	0	0.004990	0	0
C11orf30	56946	broad.mit.edu	37	11	76256959	76256959	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:76256959C>T	ENST00000529032.1	+	19	3392	c.3392C>T	c.(3391-3393)cCa>cTa	p.P1131L	C11orf30_ENST00000533248.1_Missense_Mutation_p.P1040L|C11orf30_ENST00000524490.1_Missense_Mutation_p.P1033L|C11orf30_ENST00000334736.3_Missense_Mutation_p.P1131L|C11orf30_ENST00000524767.1_Missense_Mutation_p.P1146L|C11orf30_ENST00000525919.1_Missense_Mutation_p.P1132L|C11orf30_ENST00000525038.1_Missense_Mutation_p.P1132L|C11orf30_ENST00000343878.3_Intron			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1131					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						CTGACATCACCAGTTACAAGC	0.443000													10	24					0	0	0.013537	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757888	62757888	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:62757888C>A	ENST00000281156.4	-	3	509	c.231G>T	c.(229-231)gtG>gtT	p.V77V		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	77	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		GCAATTTCCCCACAAAATTGA	0.368000													14	49					5.35267e-07	6.79139e-07	0.007413	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119128425	119128425	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:119128425G>C	ENST00000264245.4	+	11	2260	c.1728G>C	c.(1726-1728)ctG>ctC	p.L576L		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	576					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GCAAAGGCCTGTCCCAGGAGC	0.522000													7	18					0	0	0.004482	0	0
PXDNL	137902	broad.mit.edu	37	8	52384858	52384858	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:52384858G>A	ENST00000356297.4	-	8	801	c.701C>T	c.(700-702)cCc>cTc	p.P234L	PXDNL_ENST00000543296.1_Missense_Mutation_p.P234L	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	234	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGTAATTCGGGGGCTCTCTGC	0.413000													15	47					0	0	0.008871	0	0
NT5DC3	51559	broad.mit.edu	37	12	104179254	104179254	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:104179254C>A	ENST00000392876.3	-	12	1229		c.e12-1			NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3								hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						GGGTCAAATCCTGATCACAAA	0.398000													14	40					6.94344e-10	9.80119e-10	0.006122	1	0
STK17B	9262	broad.mit.edu	37	2	197004484	197004484	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:197004484T>C	ENST00000263955.4	-	7	982	c.696A>G	c.(694-696)acA>acG	p.T232T	STK17B_ENST00000409228.1_Silent_p.T232T	NM_004226.3	NP_004217.1	O94768	ST17B_HUMAN	serine/threonine kinase 17b	232	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(10)	15			OV - Ovarian serous cystadenocarcinoma(117;0.141)			CAAATGGTGATGTGTGAGTTA	0.303000													9	50					0	0	0.008291	0	0
HMCN1	83872	broad.mit.edu	37	1	186082028	186082028	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:186082028T>C	ENST00000271588.4	+	72	11303	c.11074T>C	c.(11074-11076)Tgt>Cgt	p.C3692R	HMCN1_ENST00000367492.2_Missense_Mutation_p.C3692R	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3692	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CAATTATACCTGTGTTGCCAG	0.403000													16	48					0	0	0.004990	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686417	125686417	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:125686417C>A	ENST00000371126.1	-	1	417	c.175G>T	c.(175-177)Gag>Tag	p.E59*		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	59										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CCGCCTACCTCCCGAACCTTC	0.701000													7	17					0.0167234	0.0173559	0.016723	1	0
GABRA6	2559	broad.mit.edu	37	5	161116055	161116055	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:161116055G>T	ENST00000523217.1	+	4	538	c.296G>T	c.(295-297)aGt>aTt	p.S99I	GABRA6_ENST00000274545.5_Missense_Mutation_p.S109I|RP11-348M17.2_ENST00000521984.1_RNA	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	109					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGATGGTCAGTAAAATCTGG	0.413000										TCGA Ovarian(5;0.080)			22	76					1.96895e-08	2.65144e-08	0.016522	1	0
TMEM117	84216	broad.mit.edu	37	12	44782158	44782158	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:44782158A>G	ENST00000266534.3	+	8	1375	c.1248A>G	c.(1246-1248)cgA>cgG	p.R416R	TMEM117_ENST00000546978.1_3'UTR|TMEM117_ENST00000536799.1_Silent_p.R312R|TMEM117_ENST00000551577.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	416						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TCTTTGGACGATTTTTGAAAA	0.418000													23	62					0	0	0.018920	0	0
RGAG1	57529	broad.mit.edu	37	X	109696888	109696888	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:109696888G>A	ENST00000465301.2	+	3	3289	c.3043G>A	c.(3043-3045)Gcc>Acc	p.A1015T	RGAG1_ENST00000540313.1_Missense_Mutation_p.A1015T	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1015										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TGGAAGGATGGCCACAGCGCC	0.502000													27	418					0	0	0.005524	0	0
EMD	2010	broad.mit.edu	37	X	153609453	153609453	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:153609453C>G	ENST00000369842.4	+	6	949	c.661C>G	c.(661-663)Cgc>Ggc	p.R221G	EMD_ENST00000492448.1_3'UTR|EMD_ENST00000369835.3_Missense_Mutation_p.R186G	NM_000117.2	NP_000108.1	P50402	EMD_HUMAN	emerin	221	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding			lung(5)	5	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCCAGGATCGCCAGGTCCC	0.577000													4	10					0	0	0.009096	0	0
AMBN	258	broad.mit.edu	37	4	71471904	71471904	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:71471904C>A	ENST00000322937.6	+	13	904	c.801C>A	c.(799-801)ggC>ggA	p.G267G	AMBN_ENST00000449493.2_Silent_p.G252G	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	267					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			TTTTCCAGGGCGGGAGAGAAG	0.488000													10	20					1.5842e-08	2.14319e-08	0.016723	1	0
NPAP1	23742	broad.mit.edu	37	15	24923440	24923440	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:24923440G>T	ENST00000329468.2	+	1	2900	c.2426G>T	c.(2425-2427)aGt>aTt	p.S809I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TTAGTGAGCAGTGCCTCTGCA	0.532000													12	38					9.05144e-12	1.34243e-11	0.016723	1	0
DDX60	55601	broad.mit.edu	37	4	169204672	169204672	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:169204672G>C	ENST00000393743.3	-	13	1938	c.1647C>G	c.(1645-1647)gtC>gtG	p.V549V		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	549							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTTTCGAAGAGACTGTTTCTA	0.358000													12	21					0	0	0.020292	0	0
SPATS1	221409	broad.mit.edu	37	6	44328186	44328186	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:44328186C>A	ENST00000288390.2	+	3	638	c.291C>A	c.(289-291)acC>acA	p.T97T	SPATS1_ENST00000323108.8_Silent_p.T97T			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	97										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTTCCAGCACCACTGCTGACT	0.438000													15	34					3.51602e-12	5.27703e-12	0.008871	1	0
AGT	183	broad.mit.edu	37	1	230846067	230846067	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:230846067G>T	ENST00000366667.4	-	2	744	c.530C>A	c.(529-531)gCg>gAg	p.A177E		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	177					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GACCTTGTGCGCATCCAGCCG	0.632000													6	16					3.86212e-05	4.50923e-05	0.008291	1	0
LMNB1	4001	broad.mit.edu	37	5	126161782	126161782	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:126161782A>T	ENST00000261366.5	+	9	1955	c.1594A>T	c.(1594-1596)Aaa>Taa	p.K532*	LMNB1_ENST00000460265.1_3'UTR	NM_001198557.1|NM_005573.3	NP_001185486.1|NP_005564.1	P20700	LMNB1_HUMAN	lamin B1	532	Tail.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GGTTATATTGAAAAATTCTCA	0.458000													6	4					0	0	0.016723	0	0
ZNF236	7776	broad.mit.edu	37	18	74620298	74620298	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:74620298C>T	ENST00000253159.8	+	14	2512	c.2314C>T	c.(2314-2316)Caa>Taa	p.Q772*	ZNF236_ENST00000320610.9_Nonsense_Mutation_p.Q774*	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	772					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCAGCAGCTCCAACAGCATCA	0.493000													22	50					0	0	0.013114	0	0
SEMA5A	9037	broad.mit.edu	37	5	9238004	9238004	+	Splice_Site	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:9238004T>A	ENST00000382496.5	-	6	936		c.e6-2			NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A						cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TTCCACAGCCTGTAGAAAACA	0.398000													18	41					0	0	0.004656	0	0
TEP1	7011	broad.mit.edu	37	14	20837665	20837665	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:20837665T>C	ENST00000262715.5	-	53	7534	c.7494A>G	c.(7492-7494)gaA>gaG	p.E2498E	TEP1_ENST00000556935.1_Silent_p.E2390E	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2498					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CTGTGGTCCATTCTCCTTCTG	0.493000													24	35					0	0	0.009535	0	0
ZIC4	84107	broad.mit.edu	37	3	147113997	147113997	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:147113997G>C	ENST00000383075.3	-	3	842	c.330C>G	c.(328-330)ccC>ccG	p.P110P	ZIC4_ENST00000425731.3_Silent_p.P148P|ZIC4_ENST00000484399.1_Silent_p.P110P|ZIC4_ENST00000525172.2_Silent_p.P160P|ZIC4_ENST00000473123.1_Silent_p.P110P|ZIC4_ENST00000491672.1_Intron	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	110						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						CAGGACCGTGGGGCGCAGCGA	0.701000													11	21					0	0	0.013537	0	0
TAS1R2	80834	broad.mit.edu	37	1	19183910	19183910	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:19183910G>T	ENST00000375371.3	-	2	419	c.398C>A	c.(397-399)tCc>tAc	p.S133Y	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	133					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CACCACACGGGAAATGTAGTT	0.547000													13	33					2.37509e-13	3.63298e-13	0.010504	1	0
NAPB	63908	broad.mit.edu	37	20	23361956	23361956	+	Splice_Site	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:23361956T>C	ENST00000377026.4	-	8	647		c.e8-2		NAPB_ENST00000472855.1_Splice_Site|NAPB_ENST00000432543.2_Splice_Site|NAPB_ENST00000398425.3_Splice_Site	NM_022080.2	NP_071363.1	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, beta						intracellular protein transport|vesicle-mediated transport	membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					TGCCCCAACCTAGGCACAGAA	0.368000													14	41					0	0	0.004007	0	0
RELN	5649	broad.mit.edu	37	7	103185706	103185706	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:103185706G>T	ENST00000424685.2	-	42	6547	c.6388C>A	c.(6388-6390)Ccc>Acc	p.P2130T	RELN_ENST00000343529.5_Missense_Mutation_p.P2130T|RELN_ENST00000428762.1_Missense_Mutation_p.P2130T			P78509	RELN_HUMAN	reelin	2130	EGF-like 5.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCACACTGGGGACCGATGTAG	0.488000													5	31					2.80697e-09	3.86289e-09	0.010729	1	0
RAB5C	5878	broad.mit.edu	37	17	40278778	40278778	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:40278778G>A	ENST00000393860.3	-	6	846	c.530C>T	c.(529-531)gCa>gTa	p.A177V	RAB5C_ENST00000346213.4_Missense_Mutation_p.A177V|RAB5C_ENST00000547517.1_Missense_Mutation_p.A210V|CTD-2132N18.3_ENST00000592574.1_Intron	NM_201434.2	NP_958842.1	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family	177					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|lung(4)|prostate(1)|skin(1)	7		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CTGACCTATTGCCATGAAGAT	0.522000													33	122					0	0	0.005524	0	0
TRPM2	7226	broad.mit.edu	37	21	45811202	45811202	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:45811202G>A	ENST00000397928.1	+	11	1933	c.1488G>A	c.(1486-1488)aaG>aaA	p.K496K	TRPM2_ENST00000300482.5_Silent_p.K496K|TRPM2_ENST00000397932.2_Silent_p.K496K|TRPM2_ENST00000300481.9_Silent_p.K496K|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	496						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TCTCCAACAAGCCTGAGTTTG	0.542000													4	12					0	0	0.001168	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772616	140772616	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140772616C>A	ENST00000398604.2	+	1	236	c.236C>A	c.(235-237)cCg>cAg	p.P79Q	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCTGAACCCGCGCAGCGGC	0.597000													8	18					0.00307968	0.00327356	0.003080	1	0
DNAH3	55567	broad.mit.edu	37	16	20996653	20996653	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:20996653C>G	ENST00000261383.3	-	48	7410	c.7411G>C	c.(7411-7413)Gaa>Caa	p.E2471Q	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2471	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTAAGATCTTCTCGCCAGTCA	0.517000													11	13					0	0	0.020292	0	0
CDH20	28316	broad.mit.edu	37	18	59221422	59221422	+	Splice_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:59221422G>A	ENST00000262717.4	+	12	2298		c.e12-1		CDH20_ENST00000536675.2_Splice_Site|CDH20_ENST00000538374.1_Splice_Site			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				GTTCCTGGCAGTGCTGGTGTT	0.517000													9	26					0	0	0.010729	0	0
TPTE	7179	broad.mit.edu	37	21	10970032	10970032	+	Silent	SNP	G	G	C	rs147186596		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:10970032G>C	ENST00000298232.7	-	6	463	c.96C>G	c.(94-96)acC>acG	p.T32T	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Silent_p.T32T|TPTE_ENST00000342420.5_Silent_p.T32T	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	32					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T32T(2)|p.E33fs*10(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGCCTCCTCGGTTGCTCCTT	0.398000													11	159					0	0	0.013537	0	0
NKAP	79576	broad.mit.edu	37	X	119077253	119077253	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:119077253G>T	ENST00000371410.3	-	1	482	c.316C>A	c.(316-318)Cgc>Agc	p.R106S		NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	106					negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding	p.R106C(1)		breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						CCGTAGGGGCGCGAGTAGCTG	0.647000													5	16					5.18039e-06	6.3348e-06	0.003080	1	0
DNM1P46	196968	broad.mit.edu	37	15	100332327	100332327	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:100332327G>T	ENST00000341853.1	-	0	1864					NR_003260.1																						GGAGGTGACTGAGTCCTGGCA	0.627000													13	22					2.32078e-09	3.21396e-09	0.003163	1	0
MFSD6L	162387	broad.mit.edu	37	17	8701314	8701314	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:8701314A>G	ENST00000329805.4	-	1	1353	c.1125T>C	c.(1123-1125)acT>acC	p.T375T		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	375						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						CTACCAAAACAGTGGTGGAGG	0.572000													4	9					0	0	0.001168	0	0
ZEB1	6935	broad.mit.edu	37	10	31816100	31816100	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:31816100G>C	ENST00000446923.2	+	9	3626	c.3235G>C	c.(3235-3237)Gat>Cat	p.D1079H	ZEB1_ENST00000542815.3_Missense_Mutation_p.D1028H|ZEB1_ENST00000361642.5_Missense_Mutation_p.D1096H|ZEB1_ENST00000320985.10_Missense_Mutation_p.D1095H|ZEB1_ENST00000560721.2_Missense_Mutation_p.D1075H	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1095	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TCTGATGAAGGATGACAGGGC	0.453000													10	29					0	0	0.016723	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563361	140563361	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140563361C>A	ENST00000361016.2	+	1	2382	c.1227C>A	c.(1225-1227)ctC>ctA	p.L409L		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		409	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGCACTCGACAGAGAAG	0.453000													15	35					6.31663e-08	8.26527e-08	0.003163	1	0
OR5AC2	81050	broad.mit.edu	37	3	97806267	97806267	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:97806267T>A	ENST00000358642.2	+	1	251	c.251T>A	c.(250-252)cTg>cAg	p.L84Q		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						CCTAGGATGCTGGTCAATTTC	0.433000													49	120					0	0	0.014410	0	0
AKNAD1	254268	broad.mit.edu	37	1	109394758	109394758	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:109394758C>A	ENST00000370001.3	-	2	797	c.529G>T	c.(529-531)Gat>Tat	p.D177Y	AKNAD1_ENST00000369995.3_Missense_Mutation_p.D177Y|AKNAD1_ENST00000369994.1_Missense_Mutation_p.D177Y|AKNAD1_ENST00000357393.4_Intron	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	177										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TTTTCACCATCCCTTTTCGGG	0.423000													7	45					7.48243e-07	9.4255e-07	0.006214	1	0
SEMA3D	223117	broad.mit.edu	37	7	84727156	84727156	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:84727156G>T	ENST00000284136.6	-	2	320	c.277C>A	c.(277-279)Ctc>Atc	p.L93I	SEMA3D_ENST00000444867.1_Missense_Mutation_p.L93I	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	93	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						ACCAGACTGAGTAGAAAGATG	0.363000													51	149					4.6707e-30	8.43801e-30	0.014410	1	0
ATP11C	286410	broad.mit.edu	37	X	138844233	138844233	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:138844233T>C	ENST00000370557.1	-	22	3545	c.2518A>G	c.(2518-2520)Agg>Ggg	p.R840G	ATP11C_ENST00000359686.2_Missense_Mutation_p.R846G|ATP11C_ENST00000361648.2_Missense_Mutation_p.R846G|ATP11C_ENST00000327569.3_Missense_Mutation_p.R846G|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370543.1_Missense_Mutation_p.R846G			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	846					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TCGCTATTCCTAGCTGCTTGG	0.368000													79	205					0	0	0.014410	0	0
OR2W5	441932	broad.mit.edu	37	1	247654783	247654783	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:247654783G>T	ENST00000522351.1	+	0	414							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGGTTGTCATGTCCCATGACC	0.607000													16	38					2.94398e-08	3.94027e-08	0.007413	1	0
MYBPC2	4606	broad.mit.edu	37	19	50957559	50957559	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:50957559G>T	ENST00000357701.5	+	18	1998	c.1947G>T	c.(1945-1947)tcG>tcT	p.S649S		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	649	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle	p.S649S(1)		breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GCATCACCTCGGTTGGAGAGG	0.642000													15	18					5.03518e-11	7.35589e-11	0.007413	1	0
COL22A1	169044	broad.mit.edu	37	8	139606410	139606410	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:139606410G>T	ENST00000303045.6	-	63	4911	c.4465C>A	c.(4465-4467)Ccg>Acg	p.P1489T	COL22A1_ENST00000435777.1_Missense_Mutation_p.P1469T|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1489	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATGTACGCCGGGGGCATCTGG	0.597000										HNSCC(7;0.00092)			5	26					1.12685e-05	1.34609e-05	0.004482	1	0
TTN	7273	broad.mit.edu	37	2	179593857	179593857	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179593857G>C	ENST00000589042.1	-	65	19132	c.18908C>G	c.(18907-18909)aCt>aGt	p.T6303S	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.T5059S|TTN_ENST00000591111.1_Missense_Mutation_p.T5986S|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5986	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAAAACAGTAGTGGTATT	0.363000													8	30					0	0	0.006214	0	0
PPP1R36	145376	broad.mit.edu	37	14	65054036	65054036	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:65054036G>T	ENST00000298705.1	+	10	932	c.836G>T	c.(835-837)cGt>cTt	p.R279L	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	279																	CGCAGGAGGCGTGAAGATGAG	0.443000													8	56					5.50884e-06	6.68985e-06	0.013537	1	0
GALNT1	2589	broad.mit.edu	37	18	33267090	33267090	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:33267090G>A	ENST00000269195.5	+	5	903	c.800G>A	c.(799-801)tGg>tAg	p.W267*	GALNT1_ENST00000537549.1_Nonsense_Mutation_p.W207*	NM_020474.3	NP_065207.2	Q10472	GALT1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	267					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(4)|stomach(1)	21						AATTTTCGCTGGTATCCTGTT	0.433000													26	66					0	0	0.005443	0	0
GRID2	2895	broad.mit.edu	37	4	94436366	94436366	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:94436366G>T	ENST00000282020.4	+	13	2255		c.e13-1		GRID2_ENST00000510992.1_Splice_Site	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2						glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CAATAATCAAGGTCTCTCCAG	0.403000													5	12					2.7689e-08	3.71726e-08	0.001984	1	0
IMPDH1	3614	broad.mit.edu	37	7	128035210	128035210	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:128035210C>G	ENST00000338791.6	-	13	1730	c.1380G>C	c.(1378-1380)aaG>aaC	p.K460N	IMPDH1_ENST00000480861.1_Missense_Mutation_p.K370N|IMPDH1_ENST00000470772.1_Missense_Mutation_p.K374N|IMPDH1_ENST00000348127.6_Missense_Mutation_p.K424N|IMPDH1_ENST00000419067.2_Missense_Mutation_p.K427N|IMPDH1_ENST00000343214.4_Missense_Mutation_p.K350N|IMPDH1_ENST00000378717.4_Missense_Mutation_p.K391N|IMPDH1_ENST00000354269.5_Missense_Mutation_p.K450N|IMPDH1_ENST00000496200.1_Missense_Mutation_p.K350N	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	375					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	GGGCCAGGGCCTTGACCACGT	0.657000													3	8					0	0	0.001168	0	0
CDH8	1006	broad.mit.edu	37	16	61687545	61687545	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:61687545G>C	ENST00000577390.1	-	12	3321	c.2367C>G	c.(2365-2367)ctC>ctG	p.L789L	CDH8_ENST00000577730.1_Intron|CDH8_ENST00000299345.6_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	789					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CAACAGAGTAGAGTTCGCCCA	0.463000													12	31					0	0	0.020292	0	0
TCEAL5	340543	broad.mit.edu	37	X	102529198	102529198	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:102529198G>T	ENST00000372680.1	-	3	588	c.294C>A	c.(292-294)agC>agA	p.S98R		NM_001012979.2	NP_001012997.1	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						CCCGCGGCTGGCTCTCTGGCT	0.587000													31	93					5.30237e-35	9.86331e-35	0.014410	1	0
NARF	26502	broad.mit.edu	37	17	80417920	80417920	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:80417920C>T	ENST00000309794.10	+	2	278	c.80C>T	c.(79-81)gCa>gTa	p.A27V	NARF_ENST00000581743.1_3'UTR|NARF_ENST00000457415.3_Missense_Mutation_p.A27V|NARF_ENST00000412079.2_5'UTR|NARF_ENST00000390006.4_5'UTR|NARF_ENST00000345415.7_Missense_Mutation_p.A27V	NM_012336.3|NM_031968.2	NP_036468.1|NP_114174.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	27						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			TCAGCCGATGCACCGAGTCCA	0.418000													3	12					0	0	0.001984	0	0
ANK2	287	broad.mit.edu	37	4	114262855	114262855	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:114262855T>C	ENST00000357077.4	+	33	3958	c.3905T>C	c.(3904-3906)aTa>aCa	p.I1302T	ANK2_ENST00000394537.3_Missense_Mutation_p.I1302T|ANK2_ENST00000506722.1_Missense_Mutation_p.I1293T|ANK2_ENST00000509550.1_Missense_Mutation_p.I478T|ANK2_ENST00000264366.6_Missense_Mutation_p.I1269T|ANK2_ENST00000504887.1_3'UTR	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1269					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCTGGCTGATAGATTGTCGA	0.328000													30	91					0	0	0.015359	0	0
ZNF597	146434	broad.mit.edu	37	16	3487213	3487213	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:3487213G>T	ENST00000301744.4	-	4	721	c.486C>A	c.(484-486)gaC>gaA	p.D162E	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						TGAAGTTTTGGTCACACTCAG	0.368000													22	43					1.26454e-06	1.58384e-06	0.005443	1	0
NDST4	64579	broad.mit.edu	37	4	115769463	115769463	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:115769463C>A	ENST00000264363.2	-	9	2526	c.1848G>T	c.(1846-1848)atG>atT	p.M616I		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	616	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TTGAAGGATGCATAAGAAGAA	0.308000													7	28					0.000157383	0.000179691	0.003080	1	0
ATP6V0D1	9114	broad.mit.edu	37	16	67487552	67487552	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:67487552G>T	ENST00000290949.3	-	2	347	c.197C>A	c.(196-198)aCg>aAg	p.T66K	ATP6V0D1_ENST00000602876.1_5'UTR|ATP6V0D1_ENST00000540149.1_Missense_Mutation_p.T66K	NM_004691.4	NP_004682.2	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	66					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex				large_intestine(3)|lung(3)|urinary_tract(2)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		GACTGACACCGTCAGAGGTGA	0.542000													22	34					7.41877e-09	1.00675e-08	0.012319	1	0
HDAC9	9734	broad.mit.edu	37	7	18687614	18687614	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:18687614T>A	ENST00000406451.3	+	10	1383	c.1233T>A	c.(1231-1233)ctT>ctA	p.L411L	HDAC9_ENST00000432645.2_Silent_p.L411L|HDAC9_ENST00000405010.3_Silent_p.L411L|HDAC9_ENST00000406072.1_Silent_p.L398L|HDAC9_ENST00000401921.1_Silent_p.L370L|HDAC9_ENST00000417496.2_Silent_p.L409L|HDAC9_ENST00000524023.1_Silent_p.L334L|HDAC9_ENST00000456174.2_Silent_p.L383L|HDAC9_ENST00000428307.2_Silent_p.L367L|HDAC9_ENST00000441542.2_Silent_p.L414L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	411					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AAAAGCTTCTTGTAGCTGGTA	0.413000													8	12					0	0	0.004482	0	0
CNTN1	1272	broad.mit.edu	37	12	41330595	41330595	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:41330595G>T	ENST00000551295.2	+	10	1115	c.998G>T	c.(997-999)tGg>tTg	p.W333L	CNTN1_ENST00000547849.1_Missense_Mutation_p.W333L|CNTN1_ENST00000347616.1_Missense_Mutation_p.W333L|CNTN1_ENST00000547702.1_Missense_Mutation_p.W333L|CNTN1_ENST00000348761.2_Missense_Mutation_p.W322L|CNTN1_ENST00000360099.3_Missense_Mutation_p.W333L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	333	Ig-like C2-type 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCCCTGAGTGGGTAGAACAC	0.413000													15	46					3.62473e-10	5.17482e-10	0.012319	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119133576	119133576	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:119133576C>A	ENST00000264245.4	+	12	3332	c.2800C>A	c.(2800-2802)Ctt>Att	p.L934I		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	934					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GGTACAGGGCCTTCAGGGTCA	0.597000													183	371					1.23855e-81	2.36401e-81	0.014410	1	0
FHOD3	80206	broad.mit.edu	37	18	34081944	34081944	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:34081944C>T	ENST00000257209.4	+	4	509	c.387C>T	c.(385-387)tcC>tcT	p.S129S	FHOD3_ENST00000445677.1_Silent_p.S129S|FHOD3_ENST00000359247.4_Silent_p.S129S|FHOD3_ENST00000590592.1_Silent_p.S129S	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	129	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCCTCTTCTCCCTGAAGCAGA	0.338000													5	20					0	0	0.001984	0	0
TBC1D30	23329	broad.mit.edu	37	12	65260617	65260617	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:65260617G>A	ENST00000542120.1	+	11	1128	c.883G>A	c.(883-885)Ggg>Agg	p.G295R	TBC1D30_ENST00000229088.6_Missense_Mutation_p.G572R|TBC1D30_ENST00000539867.1_Missense_Mutation_p.G409R			F5GYJ9	F5GYJ9_HUMAN	TBC1 domain family, member 30	409						intracellular	Rab GTPase activator activity			NS(3)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	5						TAATGCAGTGGGGTGTCTTGG	0.418000													4	8					0	0	0.009096	0	0
NLRP3	114548	broad.mit.edu	37	1	247588619	247588619	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:247588619C>A	ENST00000366497.2	+	4	2654	c.1874C>A	c.(1873-1875)cCc>cAc	p.P625H	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000348069.2_Missense_Mutation_p.P625H|NLRP3_ENST00000391828.3_Missense_Mutation_p.P625H|NLRP3_ENST00000391827.2_Missense_Mutation_p.P625H|NLRP3_ENST00000366496.2_Missense_Mutation_p.P625H|NLRP3_ENST00000336119.3_Missense_Mutation_p.P625H	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	625					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGATCCAGCCCAGCCAGCTG	0.463000													8	21					2.31682e-05	2.72312e-05	0.003163	1	0
PTPRB	5787	broad.mit.edu	37	12	71029634	71029634	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:71029634C>A	ENST00000334414.6	-	2	312	c.268G>T	c.(268-270)Gca>Tca	p.A90S	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000550358.1_Missense_Mutation_p.A90S|PTPRB_ENST00000551525.1_Missense_Mutation_p.A89S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 1.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATCGGGGTGCCTGGGAACAG	0.547000													5	13					0.000602214	0.000662587	0.014758	1	0
SEMA3A	10371	broad.mit.edu	37	7	83689838	83689838	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:83689838T>C	ENST00000265362.3	-	5	804	c.490A>G	c.(490-492)Aac>Gac	p.N164D	SEMA3A_ENST00000436949.1_Missense_Mutation_p.N164D	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	164	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CCACGGCCGTTTTCAAAATGT	0.343000													13	70					0	0	0.020292	0	0
N4BP2	55728	broad.mit.edu	37	4	40104598	40104598	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:40104598G>T	ENST00000261435.6	+	4	1549	c.1133G>T	c.(1132-1134)gGc>gTc	p.G378V		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	378						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						GGAAACCATGGCTTTGTAGCT	0.498000													13	28					3.52763e-06	4.35009e-06	0.004990	1	0
HK3	3101	broad.mit.edu	37	5	176315824	176315824	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:176315824A>G	ENST00000292432.5	-	9	1047	c.956T>C	c.(955-957)gTg>gCg	p.V319A		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	319	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCAGCCGCACCAGCTCACC	0.637000													6	9					0	0	0.004482	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20874846	20874846	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:20874846T>A	ENST00000381552.1	+	8	1252	c.884T>A	c.(883-885)tTa>tAa	p.L295*	SLCO1C1_ENST00000540354.1_Nonsense_Mutation_p.L246*|SLCO1C1_ENST00000545102.1_Nonsense_Mutation_p.L177*|SLCO1C1_ENST00000266509.2_Nonsense_Mutation_p.L295*|SLCO1C1_ENST00000545604.1_Nonsense_Mutation_p.L295*			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	295					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TTCTGGTATTTACCAAAGAGT	0.428000													7	12					0	0	0.003080	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24975516	24975516	+	Splice_Site	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:24975516A>G	ENST00000289968.6	-	7	643		c.e7+1		ARHGAP17_ENST00000441763.2_Splice_Site|ARHGAP17_ENST00000575975.1_Splice_Site|ARHGAP17_ENST00000303665.5_Splice_Site	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GAATTCTCATACCTTGCACTG	0.333000													5	65					0	0	0.001168	0	0
ING4	51147	broad.mit.edu	37	12	6761907	6761907	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:6761907C>A	ENST00000341550.4	-	5	464	c.418G>T	c.(418-420)Gct>Tct	p.A140S	ING4_ENST00000446105.2_Missense_Mutation_p.A137S|ING4_ENST00000486287.1_5'UTR|ING4_ENST00000412586.2_Missense_Mutation_p.A138S|ING4_ENST00000444704.2_Missense_Mutation_p.A117S|ING4_ENST00000423703.2_Missense_Mutation_p.A141S|ING4_ENST00000396807.4_Missense_Mutation_p.A141S			Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4	141					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	10						CGAGCACGAGCAGCTTTCTTC	0.527000													29	58					9.65963e-10	1.35916e-09	0.015359	1	0
IGDCC4	57722	broad.mit.edu	37	15	65676610	65676610	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:65676610G>T	ENST00000352385.2	-	20	3699	c.3490C>A	c.(3490-3492)Cct>Act	p.P1164T	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1164						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						ATGAGATCAGGAGCCTCTGGA	0.622000													6	9					0.000673444	0.000733603	0.008291	1	0
WDR59	79726	broad.mit.edu	37	16	74927627	74927627	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:74927627C>A	ENST00000262144.6	-	19	2080	c.1950G>T	c.(1948-1950)caG>caT	p.Q650H		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	650										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						AAGCAATATCCTGGATGATGA	0.463000													8	22					7.48243e-07	9.4255e-07	0.006214	1	0
TENM2	57451	broad.mit.edu	37	5	167689373	167689373	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:167689373A>T	ENST00000519204.1	+	28	7638	c.7520A>T	c.(7519-7521)gAt>gTt	p.D2507V	TENM2_ENST00000520394.1_Missense_Mutation_p.D2389V|TENM2_ENST00000518659.1_Missense_Mutation_p.D2628V|TENM2_ENST00000403607.2_Missense_Mutation_p.D2452V|TENM2_ENST00000545108.1_Missense_Mutation_p.D2627V					teneurin transmembrane protein 2																		GGCTCAGCCGATGGCGACCTG	0.592000													5	4					0	0	0.001984	0	0
PRKD1	5587	broad.mit.edu	37	14	30066904	30066904	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:30066904C>A	ENST00000331968.5	-	16	2456	c.2227G>T	c.(2227-2229)Gtg>Ttg	p.V743L	PRKD1_ENST00000415220.2_Missense_Mutation_p.V751L	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	743	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity	p.V743L(1)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GTACCCACCACTGACCTCCGG	0.478000													12	17					1.62849e-17	2.68258e-17	0.004007	1	0
SGK1	6446	broad.mit.edu	37	6	134583133	134583133	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:134583133G>C	ENST00000367858.5	-	2	820	c.223C>G	c.(223-225)Caa>Gaa	p.Q75E	SGK1_ENST00000524929.1_Missense_Mutation_p.Q75E	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	0					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		ACCCCTCTTTGGAAAGCATGT	0.512000													28	90					0	0	0.013726	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414164	121414164	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:121414164C>A	ENST00000393667.3	-	13	5316	c.5206G>T	c.(5206-5208)Gtc>Ttc	p.V1736F	GOLGB1_ENST00000340645.5_Missense_Mutation_p.V1731F	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1731					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TCCATTTTGACCCTTTCAAGT	0.418000													20	68					4.63292e-17	7.56079e-17	0.008871	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28296687	28296687	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:28296687C>A	ENST00000284987.5	-	8	2599	c.2478G>T	c.(2476-2478)acG>acT	p.T826T	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	826	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GAATTTCCTTCGTGGCAGAGT	0.443000													22	53					5.45024e-15	8.62218e-15	0.018920	1	0
COL9A1	1297	broad.mit.edu	37	6	70981386	70981386	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:70981386G>T	ENST00000357250.6	-	14	1273	c.1115C>A	c.(1114-1116)cCt>cAt	p.P372H	COL9A1_ENST00000320755.7_Missense_Mutation_p.P129H|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Missense_Mutation_p.P129H	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	372	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AAGCTCTCCAGGGAGTCCTGC	0.388000													10	15					1.08611e-07	1.41065e-07	0.010729	1	0
OR8J3	81168	broad.mit.edu	37	11	55905149	55905149	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:55905149C>G	ENST00000301529.1	-	1	45	c.46G>C	c.(46-48)Ggt>Cgt	p.G16R		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					CTAGAGACACCTGTGAGAATA	0.473000													23	46					0	0	0.014323	0	0
ATG16L1	55054	broad.mit.edu	37	2	234186221	234186221	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:234186221A>T	ENST00000392017.4	+	10	1219	c.962A>T	c.(961-963)cAt>cTt	p.H321L	ATG16L1_ENST00000498620.1_3'UTR|ATG16L1_ENST00000392020.4_Missense_Mutation_p.H302L|ATG16L1_ENST00000392018.1_Missense_Mutation_p.H338L|ATG16L1_ENST00000373525.5_Missense_Mutation_p.H177L|ATG16L1_ENST00000347464.5_Missense_Mutation_p.H158L	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	321					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		CAGGATGCACATGATGGGGAA	0.522000													11	26					0	0	0.010729	0	0
CLK2	1196	broad.mit.edu	37	1	155233108	155233108	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:155233108C>A	ENST00000368361.4	-	13	1716	c.1401G>T	c.(1399-1401)cgG>cgT	p.R467R	CLK2_ENST00000361168.5_Silent_p.R466R|CLK2_ENST00000355560.4_Silent_p.R465R|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000536801.1_Silent_p.R467R			P49760	CLK2_HUMAN	CDC-like kinase 2	467	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCAAGGTCAGCCGCTTAGCTG	0.572000								Other conserved DNA damage response genes					19	31					8.00594e-06	9.68211e-06	0.007413	1	0
ZNF536	9745	broad.mit.edu	37	19	30934886	30934886	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30934886C>T	ENST00000355537.3	+	2	564	c.417C>T	c.(415-417)ttC>ttT	p.F139F		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.F139F(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCAAGCGCTTCCGCTTCAACA	0.637000													10	40					0	0	0.020292	0	0
POP1	10940	broad.mit.edu	37	8	99162791	99162791	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:99162791G>T	ENST00000401707.2	+	14	2062	c.1981G>T	c.(1981-1983)Ggc>Tgc	p.G661C	POP1_ENST00000349693.3_Missense_Mutation_p.G661C	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	661					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			TAATGTCCCAGGCGATTTTCC	0.433000													14	52					3.52763e-06	4.35009e-06	0.004990	1	0
STAMBPL1	57559	broad.mit.edu	37	10	90733067	90733067	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:90733067C>A	ENST00000371927.3	+	11	2341	c.1383C>A	c.(1381-1383)ctC>ctA	p.L461L	ACTA2_ENST00000458208.1_Intron			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	0							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		CTGAACAGCTCTGAGAGAGAC	0.453000													19	18					3.51602e-12	5.27703e-12	0.008871	1	0
RPUSD4	84881	broad.mit.edu	37	11	126081354	126081354	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:126081354C>A	ENST00000298317.4	-	1	233	c.180G>T	c.(178-180)aaG>aaT	p.K60N	FAM118B_ENST00000533050.1_5'UTR|RPUSD4_ENST00000533628.1_Missense_Mutation_p.K60N	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	60					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		CCGGCTCCTTCTTTGTGTCTT	0.562000													17	46					4.4194e-11	6.49956e-11	0.013726	1	0
LONRF2	164832	broad.mit.edu	37	2	100903408	100903408	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:100903408C>G	ENST00000393437.3	-	11	2677	c.2038G>C	c.(2038-2040)Ggg>Cgg	p.G680R	LONRF2_ENST00000409647.1_Missense_Mutation_p.G437R	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	680	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						GGCATTACCCCAAAATGACTT	0.463000													25	77					0	0	0.007291	0	0
IGLV2-8	28817	broad.mit.edu	37	22	23165338	23165338	+	RNA	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:23165338C>T	ENST00000390317.2	+	0	186				MIR650_ENST00000385101.1_RNA																							TGCTCCTCCTCACCCTCCTCA	0.667000													4	10					0	0	0.014758	0	0
PRDX1	5052	broad.mit.edu	37	1	45981386	45981386	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:45981386T>C	ENST00000262746.1	-	3	539	c.200A>G	c.(199-201)aAg>aGg	p.K67R	PRDX1_ENST00000483583.1_5'UTR|PRDX1_ENST00000372079.1_Intron|PRDX1_ENST00000319248.8_Missense_Mutation_p.K67R	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	67	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					GTTGAGTTTCTTAAATTCTTC	0.413000													12	52					0	0	0.010729	0	0
CYFIP1	23191	broad.mit.edu	37	15	22962480	22962480	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:22962480C>A	ENST00000313077.7	+	20	2325	c.2200C>A	c.(2200-2202)Cag>Aag	p.Q734K	CYFIP1_ENST00000435939.2_Missense_Mutation_p.Q303K|CYFIP1_ENST00000560848.1_Missense_Mutation_p.Q734K	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	734					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ATGCAAGAATCAGGGAGCCAC	0.512000													3	7					0.004672	0.00494219	0.004672	1	0
PRKCG	5582	broad.mit.edu	37	19	54392933	54392933	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:54392933C>A	ENST00000263431.3	+	4	609	c.327C>A	c.(325-327)agC>agA	p.S109R	PRKCG_ENST00000540413.1_Missense_Mutation_p.S109R|PRKCG_ENST00000536044.1_Missense_Mutation_p.S109R|PRKCG_ENST00000542049.1_Intron	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	109					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding	p.S109R(1)		large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ATAGCTACAGCAGCCCCACCT	0.622000													18	10					2.12542e-12	3.2119e-12	0.006320	1	0
TSEN2	80746	broad.mit.edu	37	3	12560566	12560566	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:12560566A>G	ENST00000444864.1	+	7	1278	c.891A>G	c.(889-891)ttA>ttG	p.L297L	TSEN2_ENST00000415684.1_Silent_p.L297L|C3orf83_ENST00000567514.1_Intron|TSEN2_ENST00000314571.7_Silent_p.L297L|TSEN2_ENST00000454502.2_Silent_p.L264L|TSEN2_ENST00000284995.6_Silent_p.L323L|TSEN2_ENST00000402228.3_Silent_p.L323L|TSEN2_ENST00000383797.5_Silent_p.L306L	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	323					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						AGGAGCCTTTAACGATAGTGA	0.443000													23	36					0	0	0.004656	0	0
ACTN2	88	broad.mit.edu	37	1	236914888	236914888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:236914888G>T	ENST00000366578.4	+	15	1941	c.1775G>T	c.(1774-1776)aGa>aTa	p.R592I	ACTN2_ENST00000542672.1_Missense_Mutation_p.R592I|ACTN2_ENST00000546208.1_Missense_Mutation_p.R86I	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	592					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TACAACATCAGAATCAGCTCA	0.607000													14	38					2.32078e-09	3.21396e-09	0.003163	1	0
ZNF536	9745	broad.mit.edu	37	19	30935348	30935348	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30935348C>G	ENST00000355537.3	+	2	1026	c.879C>G	c.(877-879)atC>atG	p.I293M		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.I293I(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACCGCCACATCCGCATCTTGC	0.647000													15	66					0	0	0.008871	0	0
ITM2A	9452	broad.mit.edu	37	X	78618572	78618572	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:78618572C>A	ENST00000434584.2	-	2	512	c.176G>T	c.(175-177)gGa>gTa	p.G59V	ITM2A_ENST00000373298.2_Missense_Mutation_p.G103V|ITM2A_ENST00000469541.1_5'UTR	NM_001171581.1	NP_001165052.1	O43736	ITM2A_HUMAN	integral membrane protein 2A	103						integral to membrane	protein binding	p.G103V(1)		breast(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	18						AGGCTCTCCTCCACGAAGGGA	0.443000													10	9					6.40141e-05	7.44429e-05	0.010729	1	0
ATAD2	29028	broad.mit.edu	37	8	124384054	124384054	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:124384054C>G	ENST00000287394.5	-	4	499	c.392G>C	c.(391-393)cGg>cCg	p.R131P	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity	p.R131L(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTCAATGACCGAGTAACTGG	0.308000													4	15					0	0	0.014758	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733799	28733799	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:28733799C>A	ENST00000550043.1	+	0	204																											GGAGGAGAGCCTGCAGGGCTC	0.577000													6	14					0.000157383	0.000179691	0.003080	1	0
TSHR	7253	broad.mit.edu	37	14	81610368	81610368	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:81610368G>A	ENST00000541158.2	+	11	2288	c.1966G>A	c.(1966-1968)Gtt>Att	p.V656I	RP11-114N19.3_ENST00000557775.1_RNA|TSHR_ENST00000298171.2_Missense_Mutation_p.V656I			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	656			V -> F (in TTNs).		cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity	p.V656F(2)|p.V656I(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCTCATCACTGTTAGCAACTC	0.458000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						30	75					0	0	0.011902	0	0
OR5D16	390144	broad.mit.edu	37	11	55606547	55606547	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:55606547G>C	ENST00000378396.1	+	1	320	c.320G>C	c.(319-321)tGc>tCc	p.C107S		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTTTTCTTTTGCACCTTTGTA	0.433000													53	92					0	0	0.014410	0	0
CAPN6	827	broad.mit.edu	37	X	110494829	110494829	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:110494829G>C	ENST00000324068.1	-	6	1008	c.841C>G	c.(841-843)Cgc>Ggc	p.R281G	CAPN6_ENST00000541758.1_Missense_Mutation_p.R26G	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	281	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TTTCTCAGGCGAACCATATAC	0.478000													221	740					0	0	0.014410	0	0
MAP2	4133	broad.mit.edu	37	2	210559290	210559290	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:210559290G>T	ENST00000360351.4	+	7	2902	c.2396G>T	c.(2395-2397)gGt>gTt	p.G799V	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.G795V|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	799					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TACAAAAATGGTACTGTCATG	0.443000													23	47					3.01185e-09	4.13188e-09	0.021523	1	0
FERMT2	10979	broad.mit.edu	37	14	53326377	53326377	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:53326377G>A	ENST00000395631.2	-	14	1999	c.1783C>T	c.(1783-1785)Cgg>Tgg	p.R595W	FERMT2_ENST00000343279.4_Missense_Mutation_p.R602W|FERMT2_ENST00000399304.3_Missense_Mutation_p.R602W|FERMT2_ENST00000553373.1_Missense_Mutation_p.R602W|FERMT2_ENST00000557255.1_5'UTR|FERMT2_ENST00000341590.3_Missense_Mutation_p.R595W			Q96AC1	FERM2_HUMAN	fermitin family member 2	595	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GCATCCATCCGAATCAGTCTG	0.388000													4	41					0	0	0.014758	0	0
OPHN1	4983	broad.mit.edu	37	X	67283822	67283822	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:67283822G>A	ENST00000355520.5	-	21	2673	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	OPHN1_ENST00000484842.1_5'UTR|OPHN1_ENST00000540071.1_Intron	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	678	Pro-rich.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						CCTCCATCCTGCAGCCTAGAC	0.587000													40	31					0	0	0.014410	0	0
TAAR6	319100	broad.mit.edu	37	6	132891786	132891786	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:132891786C>T	ENST00000275198.1	+	1	326	c.326C>T	c.(325-327)aCc>aTc	p.T109I		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	109						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		ACTTTCCACACCTGCTGTGAT	0.498000													22	98					0	0	0.014323	0	0
DNAH8	1769	broad.mit.edu	37	6	38976746	38976746	+	Splice_Site	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:38976746G>C	ENST00000359357.3	+	87	12974	c.12720_splice	c.e87+1	p.E4240_splice	DNAH8_ENST00000441566.1_Splice_Site_p.E4204_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTCCTCATGAGGTAAGTCTTG	0.418000													31	53					0	0	0.017118	0	0
IGHV4-61	28391	broad.mit.edu	37	14	107095473	107095473	+	RNA	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:107095473G>A	ENST00000390630.2	-	0	147																											TGGGATCAGAGGCACCTCCCA	0.597000													4	66					0	0	0.014758	0	0
WDR47	22911	broad.mit.edu	37	1	109524461	109524461	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:109524461C>A	ENST00000357672.3	-	12	2583	c.2208G>T	c.(2206-2208)tgG>tgT	p.W736C	WDR47_ENST00000400794.3_Missense_Mutation_p.W772C|WDR47_ENST00000369962.3_Missense_Mutation_p.W764C|WDR47_ENST00000369965.4_Missense_Mutation_p.W765C|WDR47_ENST00000361054.3_Missense_Mutation_p.W736C			O94967	WDR47_HUMAN	WD repeat domain 47	764								p.W765C(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TCCAGCCACTCCAGGTATAAA	0.378000													37	68					4.17463e-26	7.38977e-26	0.014410	1	0
CHRM3	1131	broad.mit.edu	37	1	240072267	240072267	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:240072267C>G	ENST00000255380.4	+	5	2295	c.1516C>G	c.(1516-1518)Cca>Gca	p.P506A		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	506					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CACTTGGACCCCATACAACAT	0.498000													11	54					0	0	0.004007	0	0
APOB	338	broad.mit.edu	37	2	21236176	21236176	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:21236176G>T	ENST00000233242.1	-	25	4199	c.4072C>A	c.(4072-4074)Ctc>Atc	p.L1358I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1358					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCGTGGAGAGGTCTAGAACA	0.512000													60	189					1.75807e-36	3.28422e-36	0.014410	1	0
TMEM39A	55254	broad.mit.edu	37	3	119151022	119151022	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:119151022T>A	ENST00000319172.5	-	9	1693	c.1273A>T	c.(1273-1275)Atc>Ttc	p.I425F		NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	425						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		TCAATAAGGATGAGCAGATTT	0.398000													11	35					0	0	0.013537	0	0
TIAM2	26230	broad.mit.edu	37	6	155450889	155450889	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:155450889C>G	ENST00000461783.3	+	6	1805	c.532C>G	c.(532-534)Cac>Gac	p.H178D	TIAM2_ENST00000456144.1_Missense_Mutation_p.H178D|TIAM2_ENST00000318981.5_Missense_Mutation_p.H178D|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.H178D|TIAM2_ENST00000360366.4_Missense_Mutation_p.H178D			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	178					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GGTCGAGTTCCACAATGGTGG	0.592000													7	35					0	0	0.004482	0	0
FGA	2243	broad.mit.edu	37	4	155507252	155507252	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:155507252C>A	ENST00000302053.3	-	5	1407	c.1329G>T	c.(1327-1329)agG>agT	p.R443S	FGA_ENST00000403106.3_Missense_Mutation_p.R443S	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	443					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTTACCAGTCCTGAGCTCTT	0.468000													27	95					4.59853e-10	6.53318e-10	0.005443	1	0
VAV3	10451	broad.mit.edu	37	1	108307794	108307794	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:108307794C>A	ENST00000370056.4	-	9	1099	c.825G>T	c.(823-825)ttG>ttT	p.L275F	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000371846.4_Missense_Mutation_p.L210F|VAV3_ENST00000527011.1_Missense_Mutation_p.L275F	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	275	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CGTAAATAACCAATCTGAAAG	0.383000													7	47					5.18039e-06	6.3348e-06	0.003080	1	0
HYAL4	23553	broad.mit.edu	37	7	123509015	123509015	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:123509015G>T	ENST00000223026.4	+	3	1326	c.688G>T	c.(688-690)Gcc>Tcc	p.A230S	HYAL4_ENST00000476325.1_Missense_Mutation_p.A230S	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	230					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						TAACGTTTATGCCCCAAACTA	0.438000													13	60					1.3612e-06	1.70005e-06	0.003163	1	0
ERCC5	2073	broad.mit.edu	37	13	103506168	103506168	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:103506168T>G	ENST00000355739.4	+	3	1749	c.326T>G	c.(325-327)cTt>cGt	p.L109R	BIVM-ERCC5_ENST00000602836.1_Silent_p.A534A|ERCC5_ENST00000535557.1_Missense_Mutation_p.L109R	NM_000123.3	NP_000114.2			excision repair cross-complementing rodent repair deficiency, complementation group 5											breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	51	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACAGAGAAGCTTCTGAAAACA	0.388000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				13	96					0	0	0.020292	0	0
FCAMR	83953	broad.mit.edu	37	1	207135631	207135631	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:207135631G>T	ENST00000324852.4	-	5	1053	c.579C>A	c.(577-579)atC>atA	p.I193I	FCAMR_ENST00000400962.3_Silent_p.I193I|FCAMR_ENST00000450945.2_Silent_p.I193I	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	148						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						GGTAGCATCCGATGTCATCCG	0.522000													9	28					5.50884e-06	6.68985e-06	0.013537	1	0
UBE3B	89910	broad.mit.edu	37	12	109940927	109940927	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:109940927G>T	ENST00000342494.3	+	14	1977	c.1382G>T	c.(1381-1383)tGc>tTc	p.C461F	UBE3B_ENST00000434735.2_Missense_Mutation_p.C461F|UBE3B_ENST00000535900.1_3'UTR|UBE3B_ENST00000280774.5_Missense_Mutation_p.C461F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	461					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CAGAAGGTTTGCAACATCTGT	0.532000													15	40					1.05317e-09	1.47477e-09	0.020292	1	0
DMD	1756	broad.mit.edu	37	X	32382752	32382752	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:32382752G>T	ENST00000357033.4	-	36	5307	c.5101C>A	c.(5101-5103)Ctt>Att	p.L1701I	DMD_ENST00000378677.2_Missense_Mutation_p.L1697I	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1701	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCATCCAAAAGTGTGTCAGCC	0.373000													14	43					7.07596e-05	8.20699e-05	0.006122	1	0
USH2A	7399	broad.mit.edu	37	1	216262456	216262456	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:216262456G>A	ENST00000366943.2	-	23	5170	c.4784C>T	c.(4783-4785)aCt>aTt	p.T1595I	USH2A_ENST00000307340.3_Missense_Mutation_p.T1595I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1595	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGATCATTAGTTGTAGTTAC	0.328000										HNSCC(13;0.011)			23	86					0	0	0.021523	0	0
SLC14A1	6563	broad.mit.edu	37	18	43329753	43329753	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:43329753C>T	ENST00000589700.1	+	7	859	c.859C>T	c.(859-861)Cag>Tag	p.Q287*	SLC14A1_ENST00000535474.1_Missense_Mutation_p.P204L|SLC14A1_ENST00000502059.2_Missense_Mutation_p.P228L|SLC14A1_ENST00000321925.4_Missense_Mutation_p.P336L|SLC14A1_ENST00000436407.3_Missense_Mutation_p.P392L|SLC14A1_ENST00000586142.1_Missense_Mutation_p.P336L|SLC14A1_ENST00000415427.3_Missense_Mutation_p.P392L|SLC14A1_ENST00000402943.2_Missense_Mutation_p.P231L|SLC14A1_ENST00000591541.1_Missense_Mutation_p.P40L			Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	0						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						GTTGGATTGCCAGCTTGTACC	0.493000													8	38					0	0	0.006214	0	0
GRIK2	2898	broad.mit.edu	37	6	102483424	102483424	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:102483424G>C	ENST00000369138.1	+	14	2784	c.2294G>C	c.(2293-2295)gGc>gCc	p.G765A	GRIK2_ENST00000369134.4_Missense_Mutation_p.G716A|GRIK2_ENST00000421544.1_Missense_Mutation_p.G765A|GRIK2_ENST00000369137.3_Missense_Mutation_p.G689A|GRIK2_ENST00000318991.6_Missense_Mutation_p.G765A|GRIK2_ENST00000413795.1_Missense_Mutation_p.G765A	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	765					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AAAGGTTATGGCGTTGGCACT	0.438000													24	99					0	0	0.005524	0	0
AOAH	313	broad.mit.edu	37	7	36552770	36552770	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:36552770G>T	ENST00000431169.1	-	22	2235	c.1935C>A	c.(1933-1935)gtC>gtA	p.V645V	AOAH_ENST00000258749.5_3'UTR|AOAH_ENST00000538464.1_3'UTR|AOAH_ENST00000535891.1_3'UTR	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	0					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TTGGGCCTGTGACGTGGCAGC	0.562000													4	9					0.000442599	0.000490659	0.006214	1	0
COPS7B	64708	broad.mit.edu	37	2	232663663	232663663	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:232663663G>T	ENST00000373608.3	+	6	732	c.625G>T	c.(625-627)Gta>Tta	p.V209L	COPS7B_ENST00000409295.1_Missense_Mutation_p.V175L|COPS7B_ENST00000409091.1_Missense_Mutation_p.V102L|COPS7B_ENST00000350033.3_Missense_Mutation_p.V209L|COPS7B_ENST00000410017.1_Missense_Mutation_p.V209L|COPS7B_ENST00000410024.1_Missense_Mutation_p.V209L			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	209					cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		TCAGCAGCAGGTAGAAGCAGA	0.453000													12	18					4.3838e-07	5.58632e-07	0.016723	1	0
DLD	1738	broad.mit.edu	37	7	107557322	107557322	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:107557322A>T	ENST00000205402.5	+	10	1240	c.959A>T	c.(958-960)aAg>aTg	p.K320M	DLD_ENST00000440410.1_Missense_Mutation_p.K297M|DLD_ENST00000537148.1_Missense_Mutation_p.K221M|DLD_ENST00000437604.2_Missense_Mutation_p.K272M	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	320					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	CCCTTTACTAAGAATTTGGGA	0.393000													10	57					0	0	0.010729	0	0
C1orf173	127254	broad.mit.edu	37	1	75037337	75037337	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:75037337C>T	ENST00000326665.5	-	14	4275	c.4057G>A	c.(4057-4059)Gcc>Acc	p.A1353T	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1353	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCTCTGCGGCTGTTTCTGCC	0.512000													22	79					0	0	0.006230	0	0
MMP8	4317	broad.mit.edu	37	11	102585401	102585401	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:102585401T>G	ENST00000236826.3	-	8	1174	c.1076A>C	c.(1075-1077)cAa>cCa	p.Q359P		NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)	359	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		GGGATAACCTTGCAGAATATC	0.368000													10	24					0	0	0.013537	0	0
DPY19L2	283417	broad.mit.edu	37	12	63974458	63974458	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:63974458T>G	ENST00000324472.4	-	19	2067	c.1884A>C	c.(1882-1884)aaA>aaC	p.K628N	DPY19L2_ENST00000413230.2_Missense_Mutation_p.K75N	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	628					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TGGTACTGTATTTGATCCACT	0.323000													9	83					0	0	0.006214	0	0
C1orf173	127254	broad.mit.edu	37	1	75055654	75055654	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:75055654C>G	ENST00000326665.5	-	12	2055	c.1837G>C	c.(1837-1839)Gaa>Caa	p.E613Q	C1orf173_ENST00000420661.2_Missense_Mutation_p.E416Q|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	613	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTGGCACTTTCATCTGTGCTG	0.448000													8	35					0	0	0.004482	0	0
RBM19	9904	broad.mit.edu	37	12	114386694	114386694	+	Missense_Mutation	SNP	C	C	A	rs139661395		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:114386694C>A	ENST00000545145.2	-	10	1298	c.1220G>T	c.(1219-1221)cGg>cTg	p.R407L	RBM19_ENST00000392561.3_Missense_Mutation_p.R407L|RBM19_ENST00000261741.5_Missense_Mutation_p.R407L	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	407	RRM 3.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GGGCAGGTTCCGTACAAAGAG	0.587000													20	56					3.73808e-20	6.37289e-20	0.005443	1	0
VCAN	1462	broad.mit.edu	37	5	82817274	82817274	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:82817274G>T	ENST00000265077.3	+	7	3714	c.3149G>T	c.(3148-3150)aGt>aTt	p.S1050I	VCAN_ENST00000343200.5_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.S1002I|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.S1050I	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1050	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCTGCTCTCAGTTCTACAGCT	0.453000													10	31					0.000151284	0.000173858	0.016723	1	0
LACRT	90070	broad.mit.edu	37	12	55026991	55026991	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:55026991C>G	ENST00000257867.4	-	2	138	c.85G>C	c.(85-87)Gct>Cct	p.A29P	LACRT_ENST00000547511.1_Missense_Mutation_p.A29P	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	29					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						GCAGGATCAGCACCCGTCGAG	0.592000													35	116					0	0	0.007835	0	0
TTK	7272	broad.mit.edu	37	6	80715696	80715696	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:80715696A>G	ENST00000509894.1	+	2	965	c.136A>G	c.(136-138)Aca>Gca	p.T46A	TTK_ENST00000230510.3_Missense_Mutation_p.T46A|TTK_ENST00000369798.2_Missense_Mutation_p.T46A			P33981	TTK_HUMAN	TTK protein kinase	46					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TGCTGATACTACAGGTGAGTT	0.274000													9	40					0	0	0.004482	0	0
COL6A3	1293	broad.mit.edu	37	2	238245034	238245034	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:238245034T>C	ENST00000295550.4	-	40	9161	c.8709A>G	c.(8707-8709)ccA>ccG	p.P2903P	COL6A3_ENST00000472056.1_Silent_p.P2296P|COL6A3_ENST00000409809.1_Silent_p.P2697P|COL6A3_ENST00000347401.3_Silent_p.P2702P|COL6A3_ENST00000353578.4_Silent_p.P2697P|COL6A3_ENST00000346358.4_Silent_p.P2703P	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2903	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTTCACAGATGGCTGATTTA	0.567000													12	27					0	0	0.007413	0	0
PTGIR	5739	broad.mit.edu	37	19	47124832	47124832	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:47124832G>T	ENST00000291294.2	-	3	999	c.866C>A	c.(865-867)cCc>cAc	p.P289H	PTGIR_ENST00000597185.1_Missense_Mutation_p.P18H|PTGIR_ENST00000594275.1_Missense_Mutation_p.P46H|PTGIR_ENST00000598865.1_Missense_Mutation_p.P77H	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	289					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GAAGACCCAGGGGTCCAGGAT	0.632000													16	30					1.2644e-06	1.58384e-06	0.010504	1	0
AGAP3	116988	broad.mit.edu	37	7	150841002	150841002	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:150841002A>T	ENST00000397238.2	+	18	2708	c.2708A>T	c.(2707-2709)gAg>gTg	p.E903V	AGAP3_ENST00000463381.1_Missense_Mutation_p.E572V	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	867					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						CCCTCTGCTGAGCTGCACCGT	0.622000													6	14					0	0	0.016723	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998033	27998033	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:27998033G>T	ENST00000441525.1	-	1	1533	c.1419C>A	c.(1417-1419)atC>atA	p.I473I		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	473										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CCATGAACTGGATGATCTGGG	0.502000													7	21					2.17888e-05	2.56442e-05	0.006214	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110535121	110535121	+	Splice_Site	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:110535121T>A	ENST00000378402.5	+	75	12434		c.e75+2			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATTCTGACGTAAGTCATAAC	0.478000										HNSCC(38;0.096)			9	19					0	0	0.010729	0	0
LHCGR	3973	broad.mit.edu	37	2	48914966	48914966	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:48914966G>A	ENST00000294954.7	-	11	1991	c.1970C>T	c.(1969-1971)tCa>tTa	p.S657L	LHCGR_ENST00000401907.1_3'UTR|LHCGR_ENST00000403273.1_3'UTR|LHCGR_ENST00000344775.3_Missense_Mutation_p.S595L|LHCGR_ENST00000405626.1_Missense_Mutation_p.S630L|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	657					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GGTGTAAGCTGAAAAATCTTT	0.408000													33	102					0	0	0.009718	0	0
OR51I1	390063	broad.mit.edu	37	11	5462058	5462058	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:5462058G>T	ENST00000380211.1	-	1	686	c.687C>A	c.(685-687)gtC>gtA	p.V229V	HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGATATGATGACCAGCATGG	0.463000													17	21					1.99824e-07	2.58388e-07	0.004990	1	0
HTR3C	170572	broad.mit.edu	37	3	183773141	183773141	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:183773141T>A	ENST00000318351.1	+	3	310	c.276T>A	c.(274-276)gaT>gaA	p.D92E		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	92						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGTGGATGGATTTGGTAAGGC	0.458000													6	18					0	0	0.004482	0	0
LRP1B	53353	broad.mit.edu	37	2	141259433	141259433	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:141259433G>T	ENST00000389484.3	-	55	9644	c.8673C>A	c.(8671-8673)tgC>tgA	p.C2891*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2891	LDL-receptor class A 20.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGAACTGTTGCATGACTGTT	0.368000										TSP Lung(27;0.18)			5	10					0.000673444	0.000733603	0.008291	1	0
EYS	346007	broad.mit.edu	37	6	66115184	66115184	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:66115184A>C	ENST00000503581.1	-	6	1476	c.939T>G	c.(937-939)agT>agG	p.S313R	EYS_ENST00000370616.2_Missense_Mutation_p.S313R|EYS_ENST00000370618.3_Missense_Mutation_p.S313R|EYS_ENST00000370621.3_Missense_Mutation_p.S313R|EYS_ENST00000342421.5_Missense_Mutation_p.S313R|EYS_ENST00000393380.2_Missense_Mutation_p.S313R	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	313					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TATAAGCAGAACTGCTATTTG	0.383000													32	126					0	0	0.008740	0	0
SLC25A33	84275	broad.mit.edu	37	1	9642417	9642417	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:9642417C>T	ENST00000302692.6	+	7	1034	c.824C>T	c.(823-825)gCg>gTg	p.A275V		NM_032315.2	NP_115691.1	Q9BSK2	S2533_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier), member 33	275					transport	integral to membrane|mitochondrial inner membrane		p.A275V(1)		endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		GTCCAGACGGCGCGCCTGGTG	0.498000													3	23					0	0	0.014758	0	0
MMP19	4327	broad.mit.edu	37	12	56234974	56234974	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:56234974C>T	ENST00000322569.4	-	3	311	c.220G>A	c.(220-222)Gat>Aat	p.D74N	MMP19_ENST00000409200.3_Missense_Mutation_p.D74N|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000548629.1_Missense_Mutation_p.D74N	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	74					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						CTTGTGGCATCATCCAGCTGA	0.532000													15	24					0	0	0.008871	0	0
TOPORS	10210	broad.mit.edu	37	9	32542380	32542380	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:32542380C>A	ENST00000360538.2	-	3	2259	c.2143G>T	c.(2143-2145)Ggg>Tgg	p.G715W	TOPORS_ENST00000379858.1_Missense_Mutation_p.G650W	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	715	Arg-rich.|Interaction with TOP1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		GATTCGTACCCATCCCTGTCC	0.378000													22	89					7.87624e-14	1.21535e-13	0.016522	1	0
RYR3	6263	broad.mit.edu	37	15	33855184	33855184	+	Silent	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:33855184T>G	ENST00000389232.4	+	11	1189	c.1119T>G	c.(1117-1119)acT>acG	p.T373T	RYR3_ENST00000415757.3_Silent_p.T373T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	373	MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACGCCAAAACTTCCCGCCTGG	0.453000													28	155					0	0	0.019004	0	0
ADCY8	114	broad.mit.edu	37	8	131796004	131796004	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:131796004T>A	ENST00000286355.5	-	17	5293	c.3201A>T	c.(3199-3201)tcA>tcT	p.S1067S	ADCY8_ENST00000377928.3_Silent_p.S936S	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1067					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCAGGGCGAGTGAGAAGTCAG	0.468000										HNSCC(32;0.087)			24	48					0	0	0.008361	0	0
BTLA	151888	broad.mit.edu	37	3	112190193	112190193	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:112190193C>A	ENST00000334529.5	-	3	615	c.413G>T	c.(412-414)aGt>aTt	p.S138I	BTLA_ENST00000383680.4_Intron	NM_181780.3	NP_861445.3	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated	138				S -> G (in Ref. 1; AAP44003).	T cell costimulation		receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|large_intestine(1)|lung(5)|prostate(1)	11		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TTCTGAGGCACTTTTTACATC	0.463000													17	47					8.00594e-06	9.68211e-06	0.007413	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160277144	160277144	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:160277144G>T	ENST00000264431.4	+	23	4727	c.4308G>T	c.(4306-4308)cgG>cgT	p.R1436R		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1436					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		AGAGATCGCGGATGGTCGCAC	0.582000													4	22					0.00116845	0.00126498	0.001168	1	0
KIAA1211	57482	broad.mit.edu	37	4	57182333	57182333	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:57182333G>C	ENST00000504228.1	+	6	2770	c.2665G>C	c.(2665-2667)Gct>Cct	p.A889P	KIAA1211_ENST00000264229.6_Missense_Mutation_p.A889P|KIAA1211_ENST00000541073.1_Missense_Mutation_p.A882P			Q6ZU35	K1211_HUMAN	KIAA1211	889										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AGCGGGGAGCGCTCGTGGAGA	0.632000													6	23					0	0	0.008291	0	0
ZNF398	57541	broad.mit.edu	37	7	148851379	148851379	+	Translation_Start_Site	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:148851379A>T	ENST00000483892.1	+	0	500				ZNF398_ENST00000426851.2_De_novo_Start_InFrame|ZNF398_ENST00000540950.1_Missense_Mutation_p.R128W|ZNF398_ENST00000420008.2_De_novo_Start_InFrame|ZNF398_ENST00000485111.1_3'UTR|ZNF398_ENST00000335901.4_De_novo_Start_InFrame|ZNF398_ENST00000491174.1_De_novo_Start_InFrame|ZNF398_ENST00000475153.1_Missense_Mutation_p.R123W			Q8TD17	ZN398_HUMAN	zinc finger protein 398						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GCTGCGCAACAGGAACTTCTG	0.542000													8	20					0	0	0.004482	0	0
KIAA0319	9856	broad.mit.edu	37	6	24554859	24554859	+	Splice_Site	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:24554859T>C	ENST00000535378.1	-	20	3473	c.2830_splice	c.e20-1	p.E944_splice	KIAA0319_ENST00000430948.2_Splice_Site_p.E908_splice|KIAA0319_ENST00000537886.1_Intron|KIAA0319_ENST00000378214.3_Splice_Site_p.E953_splice|KIAA0319_ENST00000543707.1_Splice_Site_p.E953_splice	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	953					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TATACTCCACTCTGAAACACA	0.378000													4	59					0	0	0.009096	0	0
ZNF23	7571	broad.mit.edu	37	16	71483710	71483710	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:71483710T>C	ENST00000393539.2	-	6	1031	c.218A>G	c.(217-219)gAc>gGc	p.D73G	ZNF23_ENST00000564528.1_Missense_Mutation_p.D15G|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000497160.1_3'UTR|ZNF23_ENST00000428724.2_Missense_Mutation_p.D15G|ZNF23_ENST00000357254.4_Missense_Mutation_p.D73G|ZNF23_ENST00000539742.1_5'UTR|ZNF23_ENST00000417828.1_Missense_Mutation_p.D73G|RP11-510M2.10_ENST00000576258.1_RNA	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D73>?(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CTGGGAAAAGTCTCTTTGAAG	0.348000													28	46					0	0	0.015359	0	0
PPM1B	5495	broad.mit.edu	37	2	44428897	44428897	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:44428897G>T	ENST00000378551.2	+	2	971	c.559G>T	c.(559-561)Gtg>Ttg	p.V187L	PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000282412.4_Missense_Mutation_p.V187L|PPM1B_ENST00000378540.4_3'UTR|PPM1B_ENST00000409895.4_Missense_Mutation_p.V187L|PPM1B_ENST00000409432.3_Missense_Mutation_p.V187L	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	187					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGGAGGCAGCGTGATGATACA	0.458000													20	43					3.8784e-16	6.20262e-16	0.012319	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72176309	72176309	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:72176309G>T	ENST00000555818.1	+	15	4547	c.4199G>T	c.(4198-4200)aGc>aTc	p.S1400I	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.S1379I|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.S854I|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.S1379I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1400	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CACAGCAAGAGCCAAGCCGGC	0.537000													6	12					2.17888e-05	2.56442e-05	0.006214	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85466712	85466712	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:85466712T>A	ENST00000393217.2	+	11	2784	c.2723T>A	c.(2722-2724)cTt>cAt	p.L908H		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	908										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GAAGAAAAACTTGTTGACAAT	0.393000													3	21					0	0	0.003080	0	0
FBXO3	26273	broad.mit.edu	37	11	33790518	33790518	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:33790518G>A	ENST00000530401.1	-	3	242	c.222C>T	c.(220-222)ttC>ttT	p.F74F	FBXO3_ENST00000526785.1_5'UTR|FBXO3_ENST00000533103.1_5'UTR|FBXO3_ENST00000534136.1_Silent_p.F79F|FBXO3_ENST00000265651.3_Silent_p.F79F|FBXO3_ENST00000448981.2_Silent_p.F79F			Q9UK99	FBX3_HUMAN	F-box protein 3	79					proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AAGTATCTATGAAGAGAGATT	0.328000													13	445					0	0	0.016723	0	0
LRP1B	53353	broad.mit.edu	37	2	141093280	141093280	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:141093280G>T	ENST00000389484.3	-	78	12991	c.12020C>A	c.(12019-12021)tCt>tAt	p.S4007Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4007					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TACGTTGATAGAGTACCTCAG	0.453000										TSP Lung(27;0.18)			22	63					7.87624e-14	1.21535e-13	0.016522	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52704447	52704447	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:52704447G>A	ENST00000287727.3	+	4	1530	c.1358G>A	c.(1357-1359)tGc>tAc	p.C453Y	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.C453Y|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.C453Y|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.C453Y	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	453					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AAAGGAACTTGCATTAGTGAA	0.403000													16	61					0	0	0.006122	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85546867	85546867	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:85546867G>T	ENST00000393217.2	+	21	4546	c.4485G>T	c.(4483-4485)tgG>tgT	p.W1495C		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1495										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CTCAAGCATGGTTATGTAATG	0.299000													11	23					5.50884e-06	6.68985e-06	0.013537	1	0
PTPN3	5774	broad.mit.edu	37	9	112172594	112172594	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:112172594C>A	ENST00000412145.1	-	10	3575	c.1022G>T	c.(1021-1023)gGc>gTc	p.G341V	PTPN3_ENST00000394827.3_5'UTR|PTPN3_ENST00000262539.3_Missense_Mutation_p.G318V|PTPN3_ENST00000374541.2_Missense_Mutation_p.G472V|PTPN3_ENST00000446349.1_Missense_Mutation_p.G296V	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	472					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CTGATCAACGCCGTCAGGTGA	0.552000													20	58					7.33628e-21	1.25806e-20	0.014323	1	0
PHF21A	51317	broad.mit.edu	37	11	45959829	45959829	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:45959829C>T	ENST00000257821.4	-	15	2110	c.1487G>A	c.(1486-1488)aGa>aAa	p.R496K	PHF21A_ENST00000418153.2_Missense_Mutation_p.R495K|PHF21A_ENST00000323180.6_Missense_Mutation_p.R449K|PHF21A_ENST00000527753.1_5'UTR	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	495	Required for transcriptional repression.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						GCCACTTTTTCTGCAAACGCT	0.403000													4	115					0	0	0.009096	0	0
RPE65	6121	broad.mit.edu	37	1	68895600	68895600	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:68895600C>T	ENST00000262340.5	-	14	1514	c.1461G>A	c.(1459-1461)ctG>ctA	p.L487L		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	487					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						CCACCACACTCAGAACTACAC	0.408000													12	23					0	0	0.010729	0	0
ZNF536	9745	broad.mit.edu	37	19	30936096	30936096	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30936096C>T	ENST00000355537.3	+	2	1774	c.1627C>T	c.(1627-1629)Ccg>Tcg	p.P543S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TAAAGAGCATCCGCTGCAGCG	0.572000													6	35					0	0	0.013537	0	0
BRPF1	7862	broad.mit.edu	37	3	9781178	9781178	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:9781178G>T	ENST00000383829.2	+	3	1499	c.1095G>T	c.(1093-1095)acG>acT	p.T365T	BRPF1_ENST00000433861.2_Silent_p.T365T|BRPF1_ENST00000457855.1_Silent_p.T365T|BRPF1_ENST00000302054.3_Silent_p.T365T|BRPF1_ENST00000424362.1_Silent_p.T365T	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	365					histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding	p.T365T(1)		central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					TCGCCAACACGGTCTTCCTAG	0.592000													30	59					8.73648e-17	1.41004e-16	0.019004	1	0
PZP	5858	broad.mit.edu	37	12	9307398	9307398	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:9307398C>A	ENST00000261336.2	-	29	3616	c.3588G>T	c.(3586-3588)aaG>aaT	p.K1196N	PZP_ENST00000381997.2_Missense_Mutation_p.K982N	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						CCACTGGTGCCTTGGGTCTCT	0.502000													6	20					0.000442599	0.000490659	0.006214	1	0
TYRO3	7301	broad.mit.edu	37	15	41864736	41864736	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:41864736G>T	ENST00000263798.3	+	15	2073	c.1849G>T	c.(1849-1851)Gcc>Tcc	p.A617S	TYRO3_ENST00000559066.1_Missense_Mutation_p.A572S	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	617	Protein kinase.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CTTCCTGCTCGCCTCCCGGAT	0.622000													6	37					1.12685e-05	1.34609e-05	0.004482	1	0
ZP4	57829	broad.mit.edu	37	1	238050785	238050785	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:238050785C>A	ENST00000366570.4	-	5	788	c.630G>T	c.(628-630)ttG>ttT	p.L210F	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	210	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCACAGAATCCAAGAGCAGTG	0.507000													21	53					9.90768e-06	1.19164e-05	0.004656	1	0
RALGPS1	9649	broad.mit.edu	37	9	129812360	129812360	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:129812360G>T	ENST00000259351.5	+	6	606	c.339G>T	c.(337-339)caG>caT	p.Q113H	RALGPS1_ENST00000373436.1_Missense_Mutation_p.Q113H|RALGPS1_ENST00000373434.1_Missense_Mutation_p.Q113H|RALGPS1_ENST00000394022.3_Missense_Mutation_p.Q113H|RALGPS1_ENST00000424082.2_Missense_Mutation_p.Q113H	NM_014636.2	NP_055451.1	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	113	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(6)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						TAACAGCACAGACTTTAAAAA	0.373000													10	48					4.68919e-08	6.20982e-08	0.008291	1	0
DEFB126	81623	broad.mit.edu	37	20	126164	126164	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:126164G>T	ENST00000382398.3	+	2	427	c.167G>T	c.(166-168)aGg>aTg	p.R56M	DEFB126_ENST00000542572.1_Intron	NM_030931.2	NP_112193.1	Q9BYW3	DB126_HUMAN	defensin, beta 126	56					defense response to bacterium	extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GGCAAACAAAGGGACTGCTGT	0.418000													41	94					5.75399e-11	8.36425e-11	0.014410	1	0
CSMD3	114788	broad.mit.edu	37	8	113241081	113241081	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:113241081G>T	ENST00000297405.5	-	70	11112	c.10868C>A	c.(10867-10869)cCt>cAt	p.P3623H	CSMD3_ENST00000343508.3_Missense_Mutation_p.P3583H|CSMD3_ENST00000455883.2_Missense_Mutation_p.P3454H|CSMD3_ENST00000352409.3_Missense_Mutation_p.P3553H	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3623						integral to membrane|plasma membrane		p.P3623L(1)|p.P3583L(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGTACCATGAGGTTGATTTGA	0.279000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	36					1.45105e-14	2.27911e-14	0.006122	1	0
SLC44A3	126969	broad.mit.edu	37	1	95311004	95311004	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:95311004G>T	ENST00000271227.6	+	9	1158	c.1056G>T	c.(1054-1056)ctG>ctT	p.L352L	RP11-465K1.2_ENST00000422162.1_RNA|SLC44A3_ENST00000446120.2_Silent_p.L316L|SLC44A3_ENST00000467909.1_Silent_p.L304L|SLC44A3_ENST00000527077.1_Silent_p.L284L|SLC44A3_ENST00000529450.1_Silent_p.L320L|SLC44A3_ENST00000530397.1_3'UTR|SLC44A3_ENST00000532427.1_Silent_p.L272L	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	352						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	CTGTGCTGCTGAGCCTGGGAA	0.532000													34	58					2.40579e-17	3.94083e-17	0.006230	1	0
FGF1	2246	broad.mit.edu	37	5	141993534	141993534	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:141993534G>A	ENST00000359370.6	-	2	238	c.159C>T	c.(157-159)agC>agT	p.S53S	FGF1_ENST00000337706.2_Silent_p.S53S|AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000360966.5_Silent_p.S53S|FGF1_ENST00000378046.1_Silent_p.S53S|FGF1_ENST00000407758.1_Silent_p.S53S|FGF1_ENST00000419524.2_Silent_p.S53S|FGF1_ENST00000494579.1_Intron|AC005592.2_ENST00000414314.1_RNA	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	53					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	TGTGCTGGTCGCTCCTGTCCC	0.532000													10	41					0	0	0.003163	0	0
SI	6476	broad.mit.edu	37	3	164709171	164709171	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:164709171C>A	ENST00000264382.3	-	44	5140	c.5078G>T	c.(5077-5079)tGt>tTt	p.C1693F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1693	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGCTCTTGACATGGTAGGAT	0.378000										HNSCC(35;0.089)			23	76					2.32416e-17	3.82137e-17	0.014323	1	0
HIST1H2BH	8345	broad.mit.edu	37	6	26251885	26251885	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:26251885G>C	ENST00000356350.2	+	1	7	c.7G>C	c.(7-9)Gat>Cat	p.D3H		NM_003524.2	NP_003515.1	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	3					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(3)|breast(2)|large_intestine(1)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	17						TGCAATGCCTGATCCAGCTAA	0.517000													5	31					0	0	0.001168	0	0
TLR7	51284	broad.mit.edu	37	X	12905189	12905189	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:12905189G>T	ENST00000380659.3	+	3	1701	c.1562G>T	c.(1561-1563)tGc>tTc	p.C521F		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	521					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TTCCTCAAATGCCTGAATCTG	0.388000													66	183					2.60599e-31	4.73719e-31	0.014410	1	0
ODF2L	57489	broad.mit.edu	37	1	86826108	86826108	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:86826108C>A	ENST00000359242.3	-	12	1536		c.e12+1		ODF2L_ENST00000294678.2_Splice_Site|ODF2L_ENST00000394731.1_Splice_Site|ODF2L_ENST00000317336.7_Splice_Site|ODF2L_ENST00000524695.1_Splice_Site|ODF2L_ENST00000370566.3_Splice_Site|ODF2L_ENST00000370567.1_Splice_Site	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like							centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		GCAGTAGTCACCTGAGTTTTA	0.303000													5	10					0.014758	0.0153343	0.014758	1	0
CUX1	1523	broad.mit.edu	37	7	101882787	101882787	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:101882787A>T	ENST00000360264.3	+	23	3863	c.3843A>T	c.(3841-3843)tcA>tcT	p.S1281S	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000550008.2_Silent_p.S1214S|CUX1_ENST00000546411.2_Silent_p.S1168S|CUX1_ENST00000549414.2_Silent_p.S1248S|CUX1_ENST00000556210.1_Silent_p.S1112S|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Silent_p.S1270S	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1270					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CATACCCGTCACCAAAAACCA	0.592000													12	33					0	0	0.020292	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21894275	21894275	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:21894275A>T	ENST00000319481.3	-	12	1113	c.907T>A	c.(907-909)Tgc>Agc	p.C303S		NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	303	PH.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TCATCAAAGCATTTAATAAAG	0.363000													16	38					0	0	0.012319	0	0
RORC	6097	broad.mit.edu	37	1	151779972	151779972	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:151779972C>A	ENST00000356728.6	-	10	1624	c.1470G>T	c.(1468-1470)gaG>gaT	p.E490D	RORC_ENST00000318247.6_Missense_Mutation_p.E511D|RORC_ENST00000480719.1_5'UTR|RORC_ENST00000392697.3_Missense_Mutation_p.E565D	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	511	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCACAGGTGACTCGGTTTCAG	0.602000													13	51					1.67942e-08	2.2685e-08	0.006122	1	0
AMER1	139285	broad.mit.edu	37	X	63409901	63409901	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:63409901C>A	ENST00000330258.3	-	2	3538	c.3266G>T	c.(3265-3267)aGg>aTg	p.R1089M	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									AGGCCGGACCCTGGGCAGCTG	0.627000													10	7					4.3838e-07	5.58632e-07	0.016723	1	0
RXFP1	59350	broad.mit.edu	37	4	159548022	159548022	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:159548022C>A	ENST00000307765.5	+	10	1057	c.806C>A	c.(805-807)tCc>tAc	p.S269Y	RXFP1_ENST00000448688.2_Intron|RXFP1_ENST00000460056.2_Missense_Mutation_p.S188Y|RXFP1_ENST00000470033.1_Missense_Mutation_p.S236Y|RXFP1_ENST00000343542.5_Missense_Mutation_p.S269Y	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	269						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding	p.S269F(2)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ACTTTTATTTCCTGCAGTAAT	0.269000													7	17					0.000274275	0.00030716	0.004482	1	0
SEMA3D	223117	broad.mit.edu	37	7	84628848	84628848	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:84628848G>A	ENST00000284136.6	-	17	2285	c.2242C>T	c.(2242-2244)Cca>Tca	p.P748S	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	748	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TTCCACTTTGGGCCCCCCTTG	0.502000													10	30					0	0	0.010729	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877601	24877601	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:24877601G>T	ENST00000382554.3	+	3	1043	c.725G>T	c.(724-726)gGa>gTa	p.G242V		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	242					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GAGAGTCCTGGACCCTTTGTG	0.587000													11	40					4.14922e-12	6.20615e-12	0.004007	1	0
DNM1	1759	broad.mit.edu	37	9	130984572	130984572	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:130984572A>T	ENST00000341179.7	+	7	1038	c.946A>T	c.(946-948)Aac>Tac	p.N316Y	DNM1_ENST00000486160.1_Missense_Mutation_p.N316Y|DNM1_ENST00000393594.3_Missense_Mutation_p.N316Y|DNM1_ENST00000372923.3_Missense_Mutation_p.N316Y|DNM1_ENST00000475805.1_Missense_Mutation_p.N316Y	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	316					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GGAATACAAGAACTTCCGCCC	0.612000													8	9					0	0	0.003080	0	0
ATP11C	286410	broad.mit.edu	37	X	138845533	138845533	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:138845533C>A	ENST00000370557.1	-	21	3463	c.2436G>T	c.(2434-2436)ctG>ctT	p.L812L	ATP11C_ENST00000359686.2_Silent_p.L815L|ATP11C_ENST00000361648.2_Silent_p.L815L|ATP11C_ENST00000327569.3_Silent_p.L815L|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370543.1_Silent_p.L815L			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	815					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					CACCTATCGACAGAGTTATTG	0.368000													15	49					1.10923e-09	1.5508e-09	0.016522	1	0
TTN	7273	broad.mit.edu	37	2	179584853	179584853	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179584853C>A	ENST00000589042.1	-	81	23740	c.23516G>T	c.(23515-23517)aGt>aTt	p.S7839I	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S6595I|TTN_ENST00000591111.1_Missense_Mutation_p.S7522I|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7522	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTATTTTCACTCTCTCTGAT	0.433000													15	52					2.94398e-08	3.94027e-08	0.007413	1	0
FSCB	84075	broad.mit.edu	37	14	44975740	44975740	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:44975740C>G	ENST00000340446.4	-	1	742	c.451G>C	c.(451-453)Gtg>Ctg	p.V151L		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	151						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TCCTTGTCCACTTTTTCTACA	0.423000													15	69					0	0	0.007413	0	0
NUCKS1	64710	broad.mit.edu	37	1	205696904	205696904	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:205696904G>C	ENST00000367142.4	-	3	399	c.97C>G	c.(97-99)Ccc>Gcc	p.P33A		NM_022731.4	NP_073568.2	Q9H1E3	NUCKS_HUMAN	nuclear casein kinase and cyclin-dependent kinase substrate 1	33						nucleus				endometrium(4)|large_intestine(1)|lung(9)	14	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TTCTTAGTGGGAGGGCCCGAA	0.353000													12	27					0	0	0.006122	0	0
SLC45A1	50651	broad.mit.edu	37	1	8398030	8398030	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:8398030C>T	ENST00000471889.1	+	7	2137	c.1752C>T	c.(1750-1752)gcC>gcT	p.A584A	SLC45A1_ENST00000289877.8_Silent_p.A584A|SLC45A1_ENST00000377479.2_Silent_p.A618A			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	584					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTATCTACGCCTTCAGTGCTG	0.592000													5	18					0	0	0.001168	0	0
CDH2	1000	broad.mit.edu	37	18	25573592	25573592	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:25573592G>T	ENST00000269141.3	-	8	1453	c.1030C>A	c.(1030-1032)Cag>Aag	p.Q344K	CDH2_ENST00000399380.3_Missense_Mutation_p.Q313K	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	344	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AACGTATACTGTTGCACTTTC	0.378000													30	38					4.65686e-17	7.58576e-17	0.017118	1	0
HTR5A	3361	broad.mit.edu	37	7	154862699	154862699	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:154862699C>A	ENST00000287907.2	+	1	666	c.90C>A	c.(88-90)cgC>cgA	p.R30R	AC093726.4_ENST00000543018.1_Intron|AC093726.4_ENST00000395731.2_Intron|AC093726.4_ENST00000493904.1_Intron	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	30						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		ACGACCTGCGCCCCAGCTCGC	0.607000													8	21					4.75885e-15	7.542e-15	0.004990	1	0
ARMC3	219681	broad.mit.edu	37	10	23321835	23321835	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:23321835A>T	ENST00000298032.5	+	18	2376	c.2292A>T	c.(2290-2292)ctA>ctT	p.L764L	ARMC3_ENST00000376528.4_Silent_p.L501L|ARMC3_ENST00000409983.3_Silent_p.L757L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	764							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAGAGAAACTACCTGATTTCA	0.353000													12	17					0	0	0.010729	0	0
SLC24A3	57419	broad.mit.edu	37	20	19261613	19261613	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:19261613C>A	ENST00000328041.6	+	2	350	c.153C>A	c.(151-153)ctC>ctA	p.L51L	RP5-1027G4.3_ENST00000319682.2_RNA	NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	51						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AGCTTGACCTCATGGACCTCG	0.557000													3	8					0.00909568	0.00951848	0.009096	1	0
EPHA5	2044	broad.mit.edu	37	4	66197760	66197760	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:66197760C>A	ENST00000273854.3	-	17	3539	c.2939G>T	c.(2938-2940)gGc>gTc	p.G980V	EPHA5_ENST00000511294.1_Missense_Mutation_p.G981V|EPHA5_ENST00000354839.4_Missense_Mutation_p.G958V|EPHA5_ENST00000432638.2_Missense_Mutation_p.G817V	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	980	SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGTATACCGGCCCATCTTGAT	0.403000										TSP Lung(17;0.13)			21	29					2.89027e-11	4.25781e-11	0.014323	1	0
DIS3	22894	broad.mit.edu	37	13	73346347	73346347	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:73346347C>T	ENST00000377767.4	-	10	1553	c.1453G>A	c.(1453-1455)Gat>Aat	p.D485N	DIS3_ENST00000545453.1_Missense_Mutation_p.D323N|DIS3_ENST00000377780.4_Missense_Mutation_p.D455N	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	485					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCGTCTATATCAGTACATCCT	0.353000										Multiple Myeloma(4;0.011)			4	37					0	0	0.009096	0	0
BOC	91653	broad.mit.edu	37	3	113003248	113003248	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:113003248C>A	ENST00000495514.1	+	17	3424	c.2720C>A	c.(2719-2721)cCa>cAa	p.P907Q	BOC_ENST00000355385.3_Missense_Mutation_p.P907Q|BOC_ENST00000273395.4_Missense_Mutation_p.P908Q			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	907					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			ACTATGGTGCCATTGGGAGGA	0.557000													23	59					4.7796e-09	6.51629e-09	0.004656	1	0
IGHV4-61	28391	broad.mit.edu	37	14	107095340	107095340	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:107095340G>T	ENST00000390630.2	-	0	240																											ACTGCTGACGGAGCCACCAGA	0.602000													8	32					1.66031e-10	2.39367e-10	0.021523	1	0
OOSP2	219990	broad.mit.edu	37	11	59807993	59807993	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:59807993C>A	ENST00000532905.1	+	0	32				PLAC1L_ENST00000278855.2_Missense_Mutation_p.H21N			Q86WS3	PLACL_HUMAN								extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						TGAGAACCTCCATGGTAAATA	0.453000													17	45					3.99206e-14	6.20359e-14	0.007413	1	0
GPR112	139378	broad.mit.edu	37	X	135428501	135428501	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:135428501C>G	ENST00000394143.1	+	6	2927	c.2636C>G	c.(2635-2637)aCa>aGa	p.T879R	GPR112_ENST00000287534.4_Missense_Mutation_p.T816R|GPR112_ENST00000394141.1_Missense_Mutation_p.T674R|GPR112_ENST00000370652.1_Missense_Mutation_p.T879R|GPR112_ENST00000412101.1_Missense_Mutation_p.T674R	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	879					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CAAAGGGTGACAGCTTCTGTC	0.408000													228	693					0	0	0.014410	0	0
MFAP3L	9848	broad.mit.edu	37	4	170926850	170926850	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:170926850T>A	ENST00000361618.3	-	2	486	c.179A>T	c.(178-180)gAa>gTa	p.E60V	MFAP3L_ENST00000506110.1_Missense_Mutation_p.E60V|MFAP3L_ENST00000393702.3_Missense_Mutation_p.E60V	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	60	Ig-like C2-type.					integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		ACTGTTCCCTTCCTTGACTAT	0.453000													28	61					0	0	0.012213	0	0
SMCO1	255798	broad.mit.edu	37	3	196242059	196242059	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:196242059G>T	ENST00000397537.2	-	1	178	c.22C>A	c.(22-24)Ctg>Atg	p.L8M		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		AAGGATATCAGGGTTGTGGTT	0.393000													32	53					2.08457e-15	3.31567e-15	0.010818	1	0
SCAPER	49855	broad.mit.edu	37	15	76641023	76641023	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:76641023T>A	ENST00000538941.2	-	32	4355	c.3416A>T	c.(3415-3417)cAg>cTg	p.Q1139L	SCAPER_ENST00000563290.1_Missense_Mutation_p.Q1385L|SCAPER_ENST00000324767.7_Missense_Mutation_p.Q1385L	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1384			A -> T (in dbSNP:rs3743176).			endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						TTCCCAGGCCTGCTGAGGAAA	0.358000													3	9					0	0	0.004672	0	0
DNAJC6	9829	broad.mit.edu	37	1	65845187	65845187	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:65845187G>A	ENST00000395325.3	+	5	632	c.475G>A	c.(475-477)Gtc>Atc	p.V159I	DNAJC6_ENST00000263441.7_Missense_Mutation_p.V146I|DNAJC6_ENST00000371069.4_Missense_Mutation_p.V216I	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	159	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						TCCCAAAAATGTCTGTGTTGT	0.458000													39	49					0	0	0.007835	0	0
HOXC4	3221	broad.mit.edu	37	12	54448764	54448764	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:54448764C>A	ENST00000430889.2	+	2	616	c.570C>A	c.(568-570)gcC>gcA	p.A190A	HOXC4_ENST00000303406.4_Silent_p.A190A	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						TCGAGATCGCCCACTCGCTGT	0.527000													5	34					4.68919e-08	6.20982e-08	0.008291	1	0
TRPC5	7224	broad.mit.edu	37	X	111090460	111090460	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:111090460G>T	ENST00000262839.2	-	6	2500	c.1582C>A	c.(1582-1584)Cta>Ata	p.L528I		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	528					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAAGCTAGTAGTACCAGGCAG	0.458000													63	182					2.59843e-28	4.62763e-28	0.014410	1	0
TOMM20	9804	broad.mit.edu	37	1	235277206	235277206	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:235277206T>C	ENST00000366607.4	-	4	490	c.270A>G	c.(268-270)gtA>gtG	p.V90V	TOMM20_ENST00000467767.1_5'UTR	NM_014765.2	NP_055580.1	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20 homolog (yeast)	90					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding			lung(2)|prostate(1)	3	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			TCAGATGGTCTACGCCCTTCT	0.413000													13	36					0	0	0.016723	0	0
TOM1L1	10040	broad.mit.edu	37	17	52990025	52990025	+	Splice_Site	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:52990025A>T	ENST00000575882.1	+	4	575		c.e4-1		TOM1L1_ENST00000540336.1_Splice_Site|TOM1L1_ENST00000570371.1_Splice_Site|TOM1L1_ENST00000445275.2_Splice_Site|TOM1L1_ENST00000348161.4_Splice_Site|TOM1L1_ENST00000572158.1_Intron|TOM1L1_ENST00000575333.1_Splice_Site|TOM1L1_ENST00000536554.1_Splice_Site|TOM1L1_ENST00000572405.1_Splice_Site	NM_005486.2	NP_005477.2	O75674	TM1L1_HUMAN	target of myb1 (chicken)-like 1						intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	15						TTTCTAATTTAGCTTATTGAC	0.338000													15	28					0	0	0.006122	0	0
SLC6A15	55117	broad.mit.edu	37	12	85264382	85264382	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:85264382G>T	ENST00000266682.5	-	9	1911	c.1370C>A	c.(1369-1371)cCc>cAc	p.P457H	SLC6A15_ENST00000552192.1_Missense_Mutation_p.P350H|SLC6A15_ENST00000309283.7_Missense_Mutation_p.P165H	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	457					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TGACCAGAAGGGAGATGCAGG	0.443000													24	73					7.87624e-14	1.21535e-13	0.016522	1	0
SNTG1	54212	broad.mit.edu	37	8	51617247	51617247	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:51617247A>G	ENST00000522124.1	+	16	1787	c.1126A>G	c.(1126-1128)Agt>Ggt	p.S376G	SNTG1_ENST00000517473.1_Missense_Mutation_p.S376G|SNTG1_ENST00000276467.5_Missense_Mutation_p.S376G|SNTG1_ENST00000518864.1_Missense_Mutation_p.S376G	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	376	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding	p.S376C(1)		NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GGAGCTGGAAAGTGACCTCGC	0.552000													3	37					0	0	0.014758	0	0
LCE1E	353135	broad.mit.edu	37	1	152760043	152760043	+	Missense_Mutation	SNP	C	C	G	rs148284954	byFrequency	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:152760043C>G	ENST00000368770.3	+	2	321	c.268C>G	c.(268-270)Ccc>Gcc	p.P90A	LCE1E_ENST00000368771.1_Missense_Mutation_p.P90A	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	90	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTCACAGACCCCAGAGCTC	0.687000													6	12					0	0	0.008291	0	0
GSTCD	79807	broad.mit.edu	37	4	106638996	106638996	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:106638996A>T	ENST00000515279.1	+	2	446	c.226A>T	c.(226-228)Att>Ttt	p.I76F	GSTCD_ENST00000394728.3_Missense_Mutation_p.I76F|GSTCD_ENST00000394730.3_Intron|GSTCD_ENST00000360505.5_Missense_Mutation_p.I76F|GSTCD_ENST00000515255.1_Intron|GSTCD_ENST00000507281.1_Intron			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing	76						cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		AATACAGATTATTTCAAGGCA	0.388000													25	52					0	0	0.021523	0	0
FCRL5	83416	broad.mit.edu	37	1	157512753	157512753	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:157512753G>T	ENST00000361835.3	-	6	1176	c.1019C>A	c.(1018-1020)tCc>tAc	p.S340Y	FCRL5_ENST00000368191.3_Missense_Mutation_p.S255Y|FCRL5_ENST00000356953.4_Missense_Mutation_p.S340Y|FCRL5_ENST00000368190.3_Missense_Mutation_p.S340Y|FCRL5_ENST00000368189.3_Missense_Mutation_p.S340Y	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	340	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAAGCTGATGGATGCTCCCCT	0.527000													18	82					9.86323e-18	1.63087e-17	0.021523	1	0
SETBP1	26040	broad.mit.edu	37	18	42531077	42531077	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:42531077A>T	ENST00000282030.5	+	4	2068	c.1772A>T	c.(1771-1773)aAg>aTg	p.K591M		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	591						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GGACGACCAAAGAAGCAGCCT	0.532000									Schinzel-Giedion syndrome				36	80					0	0	0.014410	0	0
CDH2	1000	broad.mit.edu	37	18	25568621	25568621	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:25568621T>C	ENST00000269141.3	-	11	2031	c.1608A>G	c.(1606-1608)aaA>aaG	p.K536K	CDH2_ENST00000399380.3_Silent_p.K505K	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	536	Cadherin 4.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GATCAGATAATTTAGTGTATC	0.299000													5	17					0	0	0.001168	0	0
GPR112	139378	broad.mit.edu	37	X	135428013	135428013	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:135428013C>T	ENST00000394143.1	+	6	2439	c.2148C>T	c.(2146-2148)gcC>gcT	p.A716A	GPR112_ENST00000287534.4_Silent_p.A653A|GPR112_ENST00000394141.1_Silent_p.A511A|GPR112_ENST00000370652.1_Silent_p.A716A|GPR112_ENST00000412101.1_Silent_p.A511A	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	716					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GTACCACTGCCAATGATGCTA	0.408000													148	182					0	0	0.014410	0	0
ENGASE	64772	broad.mit.edu	37	17	77077087	77077087	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:77077087G>A	ENST00000579016.1	+	6	804	c.804G>A	c.(802-804)gtG>gtA	p.V268V	ENGASE_ENST00000539857.2_Silent_p.V82V	NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	268						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						GGGGCCTGGTGCTCTGGTATG	0.597000													4	5					0	0	0.014758	0	0
AE000661.37	0	broad.mit.edu	37	14	22946714	22946714	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:22946714C>A	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA|TRAJ58_ENST00000390481.1_RNA																							ACCAGTGGCTCTAGGTTGACC	0.473000													6	13					1.11149e-13	1.7061e-13	0.008291	1	0
IKBKB	3551	broad.mit.edu	37	8	42186654	42186654	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:42186654G>T	ENST00000520810.1	+	21	2313	c.2127G>T	c.(2125-2127)gtG>gtT	p.V709V	IKBKB_ENST00000379708.3_Silent_p.V486V|IKBKB_ENST00000416505.2_Silent_p.V650V|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000520835.1_Silent_p.V707V	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	709					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AAGAACTGGTGGCTGAAGCAC	0.398000													55	65					1.55088e-19	2.60359e-19	0.014410	1	0
TTN	7273	broad.mit.edu	37	2	179483204	179483204	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179483204C>A	ENST00000589042.1	-	252	47205	c.46981G>T	c.(46981-46983)Gta>Tta	p.V15661L	TTN_ENST00000342175.6_Missense_Mutation_p.V6788L|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V6721L|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V13093L|TTN_ENST00000591111.1_Missense_Mutation_p.V14020L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V6596L|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14020	Ig-like 98.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGTTACGTACTGGCCCAGGA	0.398000													19	43					4.35082e-09	5.95946e-09	0.010504	1	0
DAAM2	23500	broad.mit.edu	37	6	39841121	39841121	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:39841121G>C	ENST00000538976.1	+	10	1334	c.1152G>C	c.(1150-1152)ctG>ctC	p.L384L	DAAM2_ENST00000398904.2_Silent_p.L384L|DAAM2_ENST00000274867.4_Silent_p.L384L	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	384	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACCACTGCCTGCAGATGCCCT	0.552000													7	21					0	0	0.016723	0	0
KCNAB1	7881	broad.mit.edu	37	3	156009765	156009765	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:156009765C>A	ENST00000302490.8	+	1	940	c.69C>A	c.(67-69)agC>agA	p.S23R	KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000471742.1_Intron|KCNAB1_ENST00000389634.5_Missense_Mutation_p.S23R|KCNAB1_ENST00000389636.5_Intron	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	42						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GACTTCTGAGCAAGCAGAGCT	0.612000													5	26					0.00621372	0.00654154	0.006214	1	0
PRR16	51334	broad.mit.edu	37	5	120022254	120022254	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:120022254C>A	ENST00000379551.2	+	3	1053	c.696C>A	c.(694-696)ccC>ccA	p.P232P	PRR16_ENST00000407149.2_Silent_p.P255P|PRR16_ENST00000505123.1_Silent_p.P185P|PRR16_ENST00000446965.1_Silent_p.P185P	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	255	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CTCCTACACCCCATCTCCCTC	0.547000													11	56					4.3838e-07	5.58632e-07	0.016723	1	0
DOCK10	55619	broad.mit.edu	37	2	225639791	225639791	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:225639791C>A	ENST00000409592.3	-	52	5939	c.5826G>T	c.(5824-5826)caG>caT	p.Q1942H	DOCK10_ENST00000258390.7_Missense_Mutation_p.Q1948H			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1948	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CATAGGTCACCTGGATGTAGG	0.493000													6	26					0.000274275	0.00030716	0.004482	1	0
TMEM239	100288797	broad.mit.edu	37	20	2795875	2795875	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:2795875G>T	ENST00000380593.4	+	2	128	c.45G>T	c.(43-45)ccG>ccT	p.P15P	C20orf141_ENST00000380589.4_Silent_p.P15P|C20orf141_ENST00000603872.1_Silent_p.P15P|TMEM239_ENST00000554164.1_Silent_p.P15P			Q8WW34	Q8WW34_HUMAN	transmembrane protein 239	0																	GTGAGGATCCGATCCCAGTTC	0.617000													16	29					0.00400662	0.00425371	0.004007	1	0
PCDHB15	56121	broad.mit.edu	37	5	140625448	140625448	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140625448C>T	ENST00000231173.3	+	1	302	c.302C>T	c.(301-303)cCc>cTc	p.P101L		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		101	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.P101H(1)		NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTACTGAGCCCTGTATAATG	0.448000													10	48					0	0	0.008291	0	0
ENPP1	5167	broad.mit.edu	37	6	132171233	132171233	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:132171233G>T	ENST00000360971.2	+	3	437	c.417G>T	c.(415-417)acG>acT	p.T139T		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	139	SMB 1.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	ACCAGGAGACGTGCATAGAAC	0.438000													15	39					0.00074312	0.0008085	0.006122	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417643	150417643	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:150417643G>T	ENST00000307194.5	+	3	691	c.551G>T	c.(550-552)cGg>cTg	p.R184L		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCGGGGGCCGGGTCTGTGCC	0.677000													3	21					8.12818e-05	9.39019e-05	0.001984	1	0
PRMT6	55170	broad.mit.edu	37	1	107599749	107599749	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:107599749G>A	ENST00000361318.5	+	1	483	c.235G>A	c.(235-237)Gga>Aga	p.G79R	PRMT6_ENST00000370078.1_Missense_Mutation_p.G138R	NM_018137.2	NP_060607.2	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	138					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			biliary_tract(1)|breast(2)|kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	14		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		CGTCCTGCCGGGACCAGTGGA	0.667000													9	35					0	0	0.016723	0	0
TECTA	7007	broad.mit.edu	37	11	120998996	120998996	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:120998996G>T	ENST00000392793.1	+	9	2581	c.2310G>T	c.(2308-2310)cgG>cgT	p.R770R	TECTA_ENST00000264037.2_Silent_p.R770R			O75443	TECTA_HUMAN	tectorin alpha	770	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGGACTTCGGATCCTGGTGG	0.587000													5	19					1.06961e-07	1.39129e-07	0.003080	1	0
ECEL1	9427	broad.mit.edu	37	2	233349303	233349303	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:233349303G>C	ENST00000304546.1	-	6	1273	c.1063C>G	c.(1063-1065)Cgg>Ggg	p.R355G	ECEL1_ENST00000409941.1_Missense_Mutation_p.R355G	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	355					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CACTTCCACCGCAACTGTGAG	0.602000													17	49					0	0	0.015359	0	0
CREB3L4	148327	broad.mit.edu	37	1	153941652	153941652	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:153941652G>T	ENST00000368607.3	+	3	687	c.421_splice	c.e3+1	p.D141_splice	CREB3L4_ENST00000368601.1_Splice_Site_p.D141_splice|CREB3L4_ENST00000368600.3_Splice_Site_p.D121_splice|CREB3L4_ENST00000368603.1_Splice_Site_p.D141_splice|CREB3L4_ENST00000405694.3_Intron|CREB3L4_ENST00000271889.4_Splice_Site_p.D141_splice	NM_001255978.1|NM_001255980.1|NM_130898.3	NP_001242907.1|NP_001242909.1|NP_570968.1	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like 4	141					response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CATCCAGCTAGGTCAGTGTTC	0.567000													32	84					1.47244e-24	2.59079e-24	0.006230	1	0
EPB41L1	2036	broad.mit.edu	37	20	34783267	34783267	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:34783267C>T	ENST00000338074.2	+	13	1627	c.1466C>T	c.(1465-1467)aCg>aTg	p.T489M	EPB41L1_ENST00000441639.1_Intron|EPB41L1_ENST00000373941.1_Missense_Mutation_p.T489M|EPB41L1_ENST00000373946.3_Intron|EPB41L1_ENST00000373950.2_Intron|EPB41L1_ENST00000202028.5_Intron	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	489	Spectrin--actin-binding.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CAGGAAACCACGCCGAGACAC	0.572000													8	29					0	0	0.007413	0	0
TENM3	55714	broad.mit.edu	37	4	183675671	183675671	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:183675671G>C	ENST00000511685.1	+	22	4274	c.4151G>C	c.(4150-4152)tGt>tCt	p.C1384S	TENM3_ENST00000406950.2_Missense_Mutation_p.C1384S|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		CCCATGCACTGTCAGGTTCCC	0.498000													13	16					0	0	0.013537	0	0
MUC17	140453	broad.mit.edu	37	7	100678478	100678478	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:100678478A>G	ENST00000306151.4	+	3	3845	c.3781A>G	c.(3781-3783)Aca>Gca	p.T1261A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1261	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TTCCTCTCCTACAACCGCTGA	0.517000													32	100					0	0	0.021022	0	0
NUP210P1	255330	broad.mit.edu	37	3	126382337	126382337	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:126382337G>T	ENST00000357061.3	+	0	304					NR_034158.1																						CTGGCAAGGTGGTCATCATCT	0.582000													12	33					1.05317e-09	1.47477e-09	0.020292	1	0
DSG3	1830	broad.mit.edu	37	18	29037052	29037052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:29037052G>T	ENST00000257189.4	+	3	264	c.181G>T	c.(181-183)Gga>Tga	p.G61*		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	61	Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTGCAGAGAAGGAGAAGATAA	0.338000													29	120					2.46105e-21	4.23687e-21	0.010818	1	0
MED8	112950	broad.mit.edu	37	1	43853255	43853255	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:43853255C>G	ENST00000372457.4	-	3	232	c.189G>C	c.(187-189)ttG>ttC	p.L63F	MED8_ENST00000290663.6_Missense_Mutation_p.L63F|RP1-92O14.6_ENST00000436713.1_RNA|MED8_ENST00000372455.4_5'UTR	NM_001001653.2|NM_201542.3	NP_001001653.1|NP_963836.2	Q96G25	MED8_HUMAN	mediator complex subunit 8	63					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				endometrium(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	9	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTTCATGCTTCAAGACCTTGT	0.473000													82	156					0	0	0.014410	0	0
PRDM15	63977	broad.mit.edu	37	21	43259796	43259796	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:43259796C>A	ENST00000422911.1	-	7	1019	c.918G>T	c.(916-918)ggG>ggT	p.G306G	PRDM15_ENST00000447207.2_Silent_p.G269G|PRDM15_ENST00000538201.1_Silent_p.G269G|PRDM15_ENST00000269844.3_Silent_p.G635G|PRDM15_ENST00000398548.1_Silent_p.G306G			P57071	PRD15_HUMAN	PR domain containing 15	635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TGGGTTTTCTCCCCCTTCGAG	0.592000													11	31					9.31168e-06	1.12303e-05	0.016723	1	0
IL18RAP	8807	broad.mit.edu	37	2	103053705	103053705	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:103053705C>G	ENST00000264260.2	+	6	1202	c.613C>G	c.(613-615)Cga>Gga	p.R205G	IL18RAP_ENST00000409369.1_Missense_Mutation_p.R63G	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	205	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AAGGAGCAACCGAATCGTAGT	0.383000													8	34					0	0	0.008291	0	0
SETD6	79918	broad.mit.edu	37	16	58552873	58552873	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:58552873C>A	ENST00000394266.4	+	9	1211	c.1155C>A	c.(1153-1155)gcC>gcA	p.A385A	SETD6_ENST00000219315.4_Silent_p.A454A|SETD6_ENST00000310682.2_Silent_p.A430A			Q8TBK2	SETD6_HUMAN	SET domain containing 6	454					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						AACAGCAAGCCTTACAGGTTC	0.433000													4	19					0.000602214	0.000662587	0.014758	1	0
PXDN	7837	broad.mit.edu	37	2	1687855	1687855	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:1687855C>T	ENST00000252804.4	-	5	535	c.485G>A	c.(484-486)aGg>aAg	p.R162K		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	162					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AACTCACAGCCTCTCGAGCTT	0.428000													5	15					0	0	0.001984	0	0
MARCH11	441061	broad.mit.edu	37	5	16067613	16067613	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:16067613C>A	ENST00000332432.8	-	4	1375	c.1176G>T	c.(1174-1176)tcG>tcT	p.S392S		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	392						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						CAACCTCCCCCGAGCTGTTAT	0.458000													50	157					1.38909e-20	2.37281e-20	0.014410	1	0
DIP2C	22982	broad.mit.edu	37	10	436004	436004	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:436004C>A	ENST00000280886.6	-	13	1611	c.1524G>T	c.(1522-1524)ctG>ctT	p.L508L	DIP2C_ENST00000381496.3_Silent_p.L401L	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	508						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CCGTCACACCCAGCACACTGC	0.587000													91	43					9.06123e-46	1.70724e-45	0.014410	1	0
AHSG	197	broad.mit.edu	37	3	186331122	186331122	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:186331122T>C	ENST00000411641.2	+	1	411	c.192T>C	c.(190-192)gaT>gaC	p.D64D	AHSG_ENST00000273784.5_Silent_p.D64D			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	64	Cystatin fetuin-A-type 1.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		ACCAGATTGATGAAGTAAAGG	0.453000													8	21					0	0	0.006214	0	0
RAD23B	5887	broad.mit.edu	37	9	110087285	110087285	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:110087285G>T	ENST00000358015.3	+	9	1467	c.1116_splice	c.e9+1	p.R372_splice	RAD23B_ENST00000416373.2_Splice_Site_p.R300_splice	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	372	UBA 2.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CTATAGAAAGGGTGAGTTTAA	0.458000								Direct reversal of damage;Nucleotide excision repair (NER)					3	44					0.004672	0.00494219	0.004672	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303813	151303813	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:151303813G>T	ENST00000370323.4	-	4	596	c.280C>A	c.(280-282)Ccc>Acc	p.P94T	MAGEA10_ENST00000244096.3_Missense_Mutation_p.P94T|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	94								p.P94T(1)		endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ACGACCGAGGGGGAGGAGCAG	0.547000													45	111					7.05377e-20	1.191e-19	0.014410	1	0
MGAM	8972	broad.mit.edu	37	7	141730463	141730463	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:141730463C>G	ENST00000475668.2	+	12	1430	c.1376C>G	c.(1375-1377)tCt>tGt	p.S459C	MGAM_ENST00000549489.2_Missense_Mutation_p.S459C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	459	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCCAACAACTCTTCCTCAAGT	0.458000													39	94					0	0	0.014410	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269348	30269348	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:30269348C>A	ENST00000378981.3	+	4	1059	c.738C>A	c.(736-738)acC>acA	p.T246T	MAGEB1_ENST00000397548.2_Silent_p.T246T|MAGEB1_ENST00000397550.1_Silent_p.T246T	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	246	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						AGTTCATCACCCAAGATCTGG	0.493000													15	30					6.31663e-08	8.26527e-08	0.003163	1	0
NWD1	284434	broad.mit.edu	37	19	16874686	16874686	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:16874686G>T	ENST00000524140.2	+	9	2599	c.2181G>T	c.(2179-2181)cgG>cgT	p.R727R	NWD1_ENST00000549814.1_Silent_p.R727R|NWD1_ENST00000523826.1_Silent_p.R521R|NWD1_ENST00000379808.3_Silent_p.R727R|NWD1_ENST00000339803.6_Silent_p.R592R|NWD1_ENST00000552788.1_Silent_p.R727R	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	727							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAAACCTGCGGAAGCTGAAGG	0.592000													11	13					0.000566183	0.000626871	0.004990	1	0
GDF6	392255	broad.mit.edu	37	8	97172676	97172676	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:97172676G>T	ENST00000287020.5	-	1	344	c.245C>A	c.(244-246)gCg>gAg	p.A82E		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	82					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					CGGCTCCTGCGCCCGGGGCTG	0.697000													4	16					0.000274275	0.00030716	0.004482	1	0
LPHN2	23266	broad.mit.edu	37	1	82416074	82416074	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:82416074G>A	ENST00000370728.1	+	9	2045	c.1400G>A	c.(1399-1401)aGa>aAa	p.R467K	LPHN2_ENST00000370727.1_Missense_Mutation_p.R467K|LPHN2_ENST00000359929.3_Missense_Mutation_p.R467K|LPHN2_ENST00000335786.5_Missense_Mutation_p.R467K|LPHN2_ENST00000370730.1_Missense_Mutation_p.R467K|LPHN2_ENST00000271029.4_Missense_Mutation_p.R467K|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370715.1_Missense_Mutation_p.R467K|LPHN2_ENST00000319517.6_Missense_Mutation_p.R467K|LPHN2_ENST00000370721.1_Missense_Mutation_p.R405K|LPHN2_ENST00000370713.1_Missense_Mutation_p.R467K|LPHN2_ENST00000370725.1_Missense_Mutation_p.R467K|LPHN2_ENST00000370723.1_Missense_Mutation_p.R467K|LPHN2_ENST00000394879.1_Missense_Mutation_p.R467K|LPHN2_ENST00000370717.2_Missense_Mutation_p.R467K			O95490	LPHN2_HUMAN	latrophilin 2	467					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTGCCAGAGAGATTCTGTGAA	0.453000													11	29					0	0	0.003163	0	0
HERC2P2	400322	broad.mit.edu	37	15	23283313	23283313	+	RNA	SNP	C	C	A	rs145817269	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:23283313C>A	ENST00000560464.1	-	0	5097																											ACCGCCGCAGCGTGTGCCTTT	0.453000													6	32					4.68919e-08	6.20982e-08	0.008291	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656626	40656626	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:40656626C>A	ENST00000406785.1	-	2	984	c.795G>T	c.(793-795)agG>agT	p.R265S	SLC8A1_ENST00000403092.1_Missense_Mutation_p.R265S|SLC8A1_ENST00000405269.1_Missense_Mutation_p.R265S|SLC8A1_ENST00000332839.4_Missense_Mutation_p.R265S|SLC8A1_ENST00000542756.1_Missense_Mutation_p.R265S|SLC8A1_ENST00000402441.1_Missense_Mutation_p.R265S|SLC8A1_ENST00000408028.2_Missense_Mutation_p.R265S|SLC8A1_ENST00000542024.1_Missense_Mutation_p.R265S|SLC8A1_ENST00000405901.3_Missense_Mutation_p.R265S|SLC8A1_ENST00000406391.2_Missense_Mutation_p.R265S			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	265	Calmodulin-binding (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAGCTCGATACCTCTTGTAGA	0.443000													25	63					1.08971e-26	1.93286e-26	0.006320	1	0
TBC1D7	51256	broad.mit.edu	37	6	13307837	13307837	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:13307837T>A	ENST00000607658.1	-	5	729	c.579A>T	c.(577-579)ttA>ttT	p.L193F	TBC1D7_ENST00000607532.1_5'UTR|TBC1D7_ENST00000379307.2_Missense_Mutation_p.L193F|TBC1D7_ENST00000343141.4_Missense_Mutation_p.L174F|TBC1D7_ENST00000356436.4_Missense_Mutation_p.L220F|TBC1D7_ENST00000379300.3_Missense_Mutation_p.L220F			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	220	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			CTTGCCTCTGTAAACTGGATT	0.468000													25	54					0	0	0.008361	0	0
WDFY3	23001	broad.mit.edu	37	4	85605170	85605170	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:85605170A>C	ENST00000322366.6	-	62	10008	c.9601T>G	c.(9601-9603)Tgc>Ggc	p.C3201G	WDFY3_ENST00000295888.4_Missense_Mutation_p.C3218G			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3218						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GACATGCAGCAGCAGATGATC	0.502000													7	24					0	0	0.006214	0	0
C12orf50	160419	broad.mit.edu	37	12	88376957	88376957	+	Missense_Mutation	SNP	G	G	T	rs141441001		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:88376957G>T	ENST00000298699.2	-	12	1322	c.1142C>A	c.(1141-1143)aCa>aAa	p.T381K	C12orf50_ENST00000550553.1_Missense_Mutation_p.T342K	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	381										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						ATTATATGATGTTGACGTATA	0.284000													7	44					0.00198382	0.00211897	0.001984	1	0
OR5R1	219479	broad.mit.edu	37	11	56185706	56185706	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:56185706C>A	ENST00000312253.1	-	1	2	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					TAACTTCAGCCATTTATCCTA	0.383000													27	62					7.01153e-11	1.01754e-10	0.007291	1	0
GKN1	56287	broad.mit.edu	37	2	69207144	69207144	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:69207144G>T	ENST00000377938.2	+	5	520	c.457G>T	c.(457-459)Gca>Tca	p.A153S		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	153	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						AAAAAACATTGCAAACATGTG	0.512000													11	62					4.3838e-07	5.58632e-07	0.016723	1	0
EPHA10	284656	broad.mit.edu	37	1	38227235	38227235	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:38227235G>T	ENST00000373048.4	-	3	691	c.692C>A	c.(691-693)tCc>tAc	p.S231Y	EPHA10_ENST00000319637.6_Missense_Mutation_p.S231Y|EPHA10_ENST00000427468.2_Missense_Mutation_p.S231Y	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	231						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACCAGTGTGGAGAAGGCGCT	0.711000													3	4					0.00909568	0.00951848	0.009096	1	0
TMEM119	338773	broad.mit.edu	37	12	108985620	108985620	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:108985620G>A	ENST00000392806.3	-	2	708	c.540C>T	c.(538-540)acC>acT	p.T180T		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	180						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TGAGGTTCTGGGTGGCGGCCA	0.701000													4	17					0	0	0.003080	0	0
CD22	933	broad.mit.edu	37	19	35829208	35829208	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:35829208G>A	ENST00000085219.5	+	6	1189	c.1123G>A	c.(1123-1125)Gga>Aga	p.G375R	CD22_ENST00000341773.6_Intron|CD22_ENST00000594250.1_Intron|CD22_ENST00000536635.2_Intron|CD22_ENST00000270311.6_Missense_Mutation_p.G255R|CD22_ENST00000419549.2_Missense_Mutation_p.G203R|CD22_ENST00000544992.2_Missense_Mutation_p.G375R	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	375	Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AGAAATGCAGGGAAGGACAGA	0.507000													68	185					0	0	0.014410	0	0
DNMBP	23268	broad.mit.edu	37	10	101648710	101648710	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:101648710C>A	ENST00000342239.3	-	12	3320	c.3228_splice	c.e12-1	p.E1077_splice	DNMBP_ENST00000472036.1_5'UTR|DNMBP_ENST00000543621.1_Splice_Site_p.E299_splice|DNMBP_ENST00000540316.1_5'UTR|DNMBP_ENST00000324109.4_Splice_Site_p.E1053_splice			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1053	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CATGCGGACTCCTGGAGCCAG	0.502000													11	17					3.32936e-07	4.26741e-07	0.006122	1	0
SNX27	81609	broad.mit.edu	37	1	151638447	151638447	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:151638447G>C	ENST00000368843.3	+	6	1065	c.945G>C	c.(943-945)gtG>gtC	p.V315V	SNX27_ENST00000368838.1_Silent_p.V222V|SNX27_ENST00000482791.1_3'UTR|SNX27_ENST00000458013.2_Silent_p.V315V	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	315	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTACGACAGTGAATTACTTTG	0.363000													13	39					0	0	0.003163	0	0
ASAP2	8853	broad.mit.edu	37	2	9475237	9475237	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:9475237G>C	ENST00000281419.3	+	9	1118	c.778G>C	c.(778-780)Gat>Cat	p.D260H	ASAP2_ENST00000315273.4_Missense_Mutation_p.D260H	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	260					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						ACAGGCCCAGGATGAAGAAAG	0.408000													11	48					0	0	0.016723	0	0
PLSCR4	57088	broad.mit.edu	37	3	145917718	145917718	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:145917718C>T	ENST00000354952.2	-	6	746	c.506G>A	c.(505-507)cGg>cAg	p.R169Q	PLSCR4_ENST00000383083.2_Intron|PLSCR4_ENST00000493382.1_Missense_Mutation_p.R169Q|PLSCR4_ENST00000446574.2_Missense_Mutation_p.R169Q|PLSCR4_ENST00000433593.2_Intron	NM_020353.2	NP_065086.2	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4	169					blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			kidney(1)|large_intestine(6)|lung(9)|urinary_tract(1)	17						CCTTAGTGTCCGATAGGCATT	0.433000													16	15					0	0	0.006122	0	0
FERMT1	55612	broad.mit.edu	37	20	6077579	6077579	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:6077579G>A	ENST00000217289.4	-	8	1847	c.1059C>T	c.(1057-1059)acC>acT	p.T353T	FERMT1_ENST00000536936.1_Silent_p.T96T	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	353	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CACCTTCTAGGGTTACTTCCA	0.423000													4	206					0	0	0.014758	0	0
PLB1	151056	broad.mit.edu	37	2	28739721	28739721	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:28739721G>A	ENST00000422425.2	+	2	146	c.102G>A	c.(100-102)ggG>ggA	p.G34G	PLB1_ENST00000327757.5_Silent_p.G34G	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	34					lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					CATTGGAAGGGCAGCTATGGC	0.488000													13	34					0	0	0.012319	0	0
SLC41A2	84102	broad.mit.edu	37	12	105280131	105280131	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:105280131C>A	ENST00000258538.3	-	5	1094	c.967G>T	c.(967-969)Ggc>Tgc	p.G323C		NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	323						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						ATAAGGTCGCCAAAACTAGCA	0.373000													14	18					4.7546e-09	6.49229e-09	0.004007	1	0
CCDC33	80125	broad.mit.edu	37	15	74623621	74623621	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:74623621G>T	ENST00000321288.5	+	17	2364	c.2364G>T	c.(2362-2364)caG>caT	p.Q788H	CCDC33_ENST00000558821.1_Missense_Mutation_p.Q178H|CCDC33_ENST00000398814.3_Missense_Mutation_p.Q585H|CCDC33_ENST00000268082.4_Missense_Mutation_p.Q178H			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	788							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ACAGGCAGCAGGGAAAGCCCT	0.632000													6	9					0.000442599	0.000490659	0.006214	1	0
OR51V1	283111	broad.mit.edu	37	11	5221887	5221887	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:5221887G>A	ENST00000321255.1	-	1	43	c.44C>T	c.(43-45)aCc>aTc	p.T15I		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTCGTGCTGGTGCTAGGGCT	0.413000													23	37					0	0	0.005443	0	0
ZNF536	9745	broad.mit.edu	37	19	30935354	30935354	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:30935354C>T	ENST00000355537.3	+	2	1032	c.885C>T	c.(883-885)atC>atT	p.I295I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACATCCGCATCTTGCACAAGC	0.647000													14	65					0	0	0.012319	0	0
OR2A12	346525	broad.mit.edu	37	7	143792734	143792734	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:143792734T>C	ENST00000408949.2	+	1	594	c.534T>C	c.(532-534)tgT>tgC	p.C178C		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					ACTTTTTCTGTCAAATCATGT	0.473000													26	84					0	0	0.010818	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952354	33952354	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:33952354C>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							CCAGCCCCAACAGGAAACTGG	0.622000													6	16					2.17888e-05	2.56442e-05	0.006214	1	0
SYNDIG1	79953	broad.mit.edu	37	20	24565623	24565623	+	Silent	SNP	C	C	A	rs141938685	byFrequency	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:24565623C>A	ENST00000376862.3	+	3	1245	c.612C>A	c.(610-612)tcC>tcA	p.S204S	SYNDIG1_ENST00000482637.1_3'UTR	NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	204					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						TCTACTTGTCCCATGAGGTAA	0.612000													9	23					4.68919e-08	6.20982e-08	0.008291	1	0
RTTN	25914	broad.mit.edu	37	18	67817252	67817252	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:67817252C>A	ENST00000255674.6	-	16	2413	c.2127G>T	c.(2125-2127)tgG>tgT	p.W709C	RTTN_ENST00000454359.1_Missense_Mutation_p.W709C|RTTN_ENST00000437017.1_Missense_Mutation_p.W709C	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	709							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				TAAACTTGTTCCAGGTCAATG	0.423000													15	49					3.45872e-05	4.05983e-05	0.004007	1	0
SLC25A5	292	broad.mit.edu	37	X	118604335	118604335	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:118604335G>T	ENST00000317881.8	+	3	714		c.e3-1		SLC25A5_ENST00000460013.1_Splice_Site	NM_001152.4	NP_001143.2	P05141	ADT2_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5						chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid|MMXD complex	adenine transmembrane transporter activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(2)	12					Clodronate(DB00720)	CCTATTCCCAGGAATGCTTCC	0.473000													32	54					1.60099e-16	2.57448e-16	0.021022	1	0
XIST	7503	broad.mit.edu	37	X	73068841	73068841	+	RNA	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:73068841C>T	ENST00000429829.1	-	0	3747					NR_001564.2																						GTCAGTCCCACTGCTGTTATG	0.363000													11	8					0	0	0.013537	0	0
LCA10	100996465	broad.mit.edu	37	X	153152423	153152423	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:153152423A>G	ENST00000357566.1	+	6	809	c.303A>G	c.(301-303)gcA>gcG	p.A101A																								GCAGCCCTGCACAGGATCGAG	0.597000													3	19					0	0	0.009096	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111794299	111794299	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:111794299G>C	ENST00000452346.2	+	15	1918	c.1915G>C	c.(1915-1917)Gag>Cag	p.E639Q	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.E513Q			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	639	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CATCTCCAGGGAGTGGCTTCT	0.552000													34	76					0	0	0.014410	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													4	106					0	0	0.009096	0	0
BCHE	590	broad.mit.edu	37	3	165547419	165547419	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:165547419T>C	ENST00000264381.3	-	2	1569	c.1403A>G	c.(1402-1404)tAt>tGt	p.Y468C	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	468					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TTCAATTTCATAGCCATGCAT	0.398000													13	53					0	0	0.020292	0	0
IGSF1	3547	broad.mit.edu	37	X	130412615	130412615	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:130412615C>A	ENST00000370904.1	-	18	2744	c.1834G>T	c.(1834-1836)Gag>Tag	p.E612*	IGSF1_ENST00000361420.3_Nonsense_Mutation_p.E621*|IGSF1_ENST00000370903.3_Nonsense_Mutation_p.E626*|IGSF1_ENST00000370910.1_Nonsense_Mutation_p.E612*			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	621	Ig-like C2-type 6.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AACACAAACTCCTTAGTTGAG	0.622000													41	88					1.67211e-32	3.05221e-32	0.014410	1	0
WIPF1	7456	broad.mit.edu	37	2	175436403	175436403	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:175436403C>A	ENST00000409415.3	-	5	1265	c.1130G>T	c.(1129-1131)gGt>gTt	p.G377V	AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000359761.3_Splice_Site|WIPF1_ENST00000272746.5_Splice_Site|WIPF1_ENST00000409891.1_Splice_Site|WIPF1_ENST00000392546.2_Splice_Site|WIPF1_ENST00000392547.2_Splice_Site|AC018890.6_ENST00000412835.1_RNA			O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	377	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						TCTTGTCATACCTGATCGGCC	0.557000													8	27					6.31663e-08	8.26527e-08	0.003163	1	0
FREM2	341640	broad.mit.edu	37	13	39266239	39266239	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:39266239C>A	ENST00000280481.7	+	1	4974	c.4758C>A	c.(4756-4758)acC>acA	p.T1586T		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1586					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCAACAATACCAGACCTGTCA	0.428000													9	17					5.50884e-06	6.68985e-06	0.013537	1	0
KIR2DL3	3804	broad.mit.edu	37	19	55263116	55263116	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:55263116T>A	ENST00000342376.3	+	6	762	c.731T>A	c.(730-732)cTg>cAg	p.L244Q	KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		CCCAGACACCTGCATGTTCTG	0.438000													4	139					0	0	0.014758	0	0
FSTL1	11167	broad.mit.edu	37	3	120122145	120122145	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:120122145A>T	ENST00000295633.3	-	8	994	c.638T>A	c.(637-639)cTc>cAc	p.L213H	FSTL1_ENST00000424703.2_Missense_Mutation_p.L178H	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	213	EF-hand 2.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		TTGGAAGCTGAGTTTCCAATC	0.438000													14	41					0	0	0.003163	0	0
HFM1	164045	broad.mit.edu	37	1	91778956	91778956	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:91778956A>G	ENST00000370425.3	-	30	3439	c.3341T>C	c.(3340-3342)aTt>aCt	p.I1114T	HFM1_ENST00000370424.3_Missense_Mutation_p.I793T|HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000294696.5_Missense_Mutation_p.I346T	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	1114							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AGAATGGGAAATCTGTGTTTC	0.328000													9	43					0	0	0.006214	0	0
SH2D1A	4068	broad.mit.edu	37	X	123504058	123504058	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:123504058G>A	ENST00000371139.4	+	3	533	c.234G>A	c.(232-234)cgG>cgA	p.R78R	SH2D1A_ENST00000470647.1_3'UTR|SH2D1A_ENST00000360027.4_Silent_p.R78R|STAG2_ENST00000469481.1_Intron	NM_001114937.2|NM_002351.4	NP_001108409.1|NP_002342.1	O60880	SH21A_HUMAN	SH2 domain containing 1A	78	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						GATATTTCCGGAAAATAAAAA	0.363000													70	185					0	0	0.014410	0	0
ZNF736	728927	broad.mit.edu	37	7	63796756	63796756	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:63796756C>G	ENST00000355095.4	+	3	445	c.123C>G	c.(121-123)gtC>gtG	p.V41V	ZNF736_ENST00000423484.1_Silent_p.V41V	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						GAAACCTGGTCTCCTTGGGTG	0.383000													6	22					0	0	0.001168	0	0
NXF3	56000	broad.mit.edu	37	X	102337745	102337745	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:102337745C>A	ENST00000395065.3	-	8	824	c.723G>T	c.(721-723)tcG>tcT	p.S241S	NXF3_ENST00000425644.1_5'UTR|NXF3_ENST00000425463.2_Silent_p.S152S	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	241						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TTCTAGGATTCGATGCCATCT	0.512000													58	165					2.6711e-34	4.92695e-34	0.014410	1	0
C12orf65	91574	broad.mit.edu	37	12	123738429	123738429	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:123738429C>T	ENST00000253233.1	+	2	852	c.208C>T	c.(208-210)Cca>Tca	p.P70S	C12orf65_ENST00000429587.2_Missense_Mutation_p.P70S|C12orf65_ENST00000366329.2_Missense_Mutation_p.P70S|RP11-282O18.3_ENST00000541002.3_RNA	NM_152269.4	NP_689482.1	Q9H3J6	CL065_HUMAN	chromosome 12 open reading frame 65	70						mitochondrion	translation release factor activity			endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000595)|Epithelial(86;0.00199)		AGGACACGGTCCAGGGGGCCA	0.552000													18	34					0	0	0.010504	0	0
FAM46C	54855	broad.mit.edu	37	1	118166264	118166264	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:118166264A>T	ENST00000369448.3	+	2	1021	c.774A>T	c.(772-774)acA>acT	p.T258T		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	258										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		TCAGGCCCACAGACCAGGAAG	0.512000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			24	50					0	0	0.018920	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110466953	110466953	+	Splice_Site	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:110466953T>A	ENST00000378402.5	+	45	6850	c.6744_splice	c.e45-1	p.I2249_splice		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2249	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTTTGCAGATTGGAACAGAG	0.423000										HNSCC(38;0.096)			34	98					0	0	0.007835	0	0
KIAA1841	84542	broad.mit.edu	37	2	61304155	61304155	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:61304155G>T	ENST00000402291.1	+	6	773	c.532G>T	c.(532-534)Gaa>Taa	p.E178*	KIAA1841_ENST00000453873.1_Nonsense_Mutation_p.E178*|KIAA1841_ENST00000295031.5_Nonsense_Mutation_p.E178*|KIAA1841_ENST00000482513.1_3'UTR|KIAA1841_ENST00000356719.2_Nonsense_Mutation_p.E178*	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	178										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			GTACTTTGCTGAATATTTATC	0.383000													10	15					0.000673444	0.000733603	0.008291	1	0
HMGCS1	3157	broad.mit.edu	37	5	43298869	43298869	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:43298869A>C	ENST00000325110.6	-	3	405	c.199T>G	c.(199-201)Tct>Gct	p.S67A	HMGCS1_ENST00000433297.2_Missense_Mutation_p.S67A	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	67					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						ATGCAAAGAGAGTTAATATCT	0.433000													23	45					0	0	0.012319	0	0
CASP10	843	broad.mit.edu	37	2	202073835	202073835	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:202073835A>G	ENST00000286186.6	+	9	1400	c.965A>G	c.(964-966)cAt>cGt	p.H322R	CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000313728.7_Missense_Mutation_p.H255R|CASP10_ENST00000448480.1_Missense_Mutation_p.H279R|CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000272879.5_Missense_Mutation_p.H322R|CASP10_ENST00000346817.5_Missense_Mutation_p.H279R	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	322					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						TTCACAGTGCATATACACAAT	0.423000													9	23					0	0	0.013537	0	0
MYO3B	140469	broad.mit.edu	37	2	171240248	171240248	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:171240248G>T	ENST00000334231.6	+	12	1241	c.1241G>T	c.(1240-1242)cGc>cTc	p.R414L	MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Missense_Mutation_p.R405L|MYO3B_ENST00000409044.3_Missense_Mutation_p.R405L			Q8WXR4	MYO3B_HUMAN	myosin IIIB	405	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity	p.R405L(1)|p.S397_A406del(1)		breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GGGGTGAAACGCGCCTCCAAT	0.453000													28	70					1.414e-09	1.97376e-09	0.017118	1	0
MROH2B	133558	broad.mit.edu	37	5	41065564	41065564	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:41065564C>A	ENST00000399564.4	-	4	680	c.230G>T	c.(229-231)gGt>gTt	p.G77V		NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CAAAACCTCACCAGCTAGCAT	0.413000													43	115					2.73381e-35	5.09614e-35	0.014410	1	0
LUM	4060	broad.mit.edu	37	12	91502284	91502284	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:91502284A>T	ENST00000266718.4	-	2	927	c.473T>A	c.(472-474)tTg>tAg	p.L158*	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	158					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CAGGTTTACCAATCCTTCAAA	0.458000													25	62					0	0	0.018920	0	0
AP3S1	1176	broad.mit.edu	37	5	115205752	115205752	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:115205752A>G	ENST00000316788.7	+	3	757	c.200A>G	c.(199-201)cAt>cGt	p.H67R		NM_001284.2	NP_001275.1	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1 subunit	67					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)	12		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		ATTTATAGACATTATGCAACG	0.299000													7	29					0	0	0.001984	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958517	122958517	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:122958517C>A	ENST00000543897.1	-	12	3292	c.937G>T	c.(937-939)Ggc>Tgc	p.G313C	ZCCHC8_ENST00000336229.4_Missense_Mutation_p.G551C|ZCCHC8_ENST00000538116.1_Missense_Mutation_p.G162C|ZCCHC8_ENST00000536306.1_Missense_Mutation_p.G313C			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	551						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		ACGGAATTGCCAGTTAAAGGT	0.537000													55	156					5.10652e-33	9.36018e-33	0.014410	1	0
VIL1	7429	broad.mit.edu	37	2	219293043	219293043	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:219293043C>A	ENST00000248444.5	+	6	638	c.550C>A	c.(550-552)Cgt>Agt	p.R184S	VIL1_ENST00000392114.2_Intron|VIL1_ENST00000440053.1_Missense_Mutation_p.R184S	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	184	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAAGCACCCGTATGGAGAG	0.567000													4	14					0.00024832	0.000280238	0.009096	1	0
CCDC33	80125	broad.mit.edu	37	15	74574130	74574130	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:74574130G>C	ENST00000321288.5	+	12	1644	c.1644G>C	c.(1642-1644)ctG>ctC	p.L548L	CCDC33_ENST00000398814.3_Silent_p.L345L			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	548							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ACACCAGCCTGAAAACTATCA	0.592000													10	50					0	0	0.003163	0	0
GRID2	2895	broad.mit.edu	37	4	94376988	94376988	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:94376988C>T	ENST00000282020.4	+	11	1979	c.1721C>T	c.(1720-1722)gCt>gTt	p.A574V	GRID2_ENST00000510992.1_Missense_Mutation_p.A479V	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	574					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GCTTGCATTGCTGGCACAGTC	0.478000													27	77					0	0	0.008361	0	0
CIB2	10518	broad.mit.edu	37	15	78416082	78416082	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:78416082C>A	ENST00000258930.3	-	2	380		c.e2-1		CIB2_ENST00000557846.1_Intron|CIB2_ENST00000539011.1_Intron|CIB2_ENST00000560618.1_Intron	NM_006383.2	NP_006374.1	O75838	CIB2_HUMAN	calcium and integrin binding family member 2								calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	11						AGGTGCAGTCCTGTTGAGGGA	0.577000													8	32					2.17888e-05	2.56442e-05	0.006214	1	0
DNAH9	1770	broad.mit.edu	37	17	11660891	11660891	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:11660891G>T	ENST00000262442.3	+	35	6945	c.6877G>T	c.(6877-6879)Gga>Tga	p.G2293*	DNAH9_ENST00000454412.2_Nonsense_Mutation_p.G2293*	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2293	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCAGACTTGGGATGGAACCC	0.443000													23	45					9.04412e-07	1.13601e-06	0.004656	1	0
CEP192	55125	broad.mit.edu	37	18	13087592	13087592	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:13087592A>G	ENST00000506447.1	+	32	6020	c.5940A>G	c.(5938-5940)ctA>ctG	p.L1980L	CEP192_ENST00000430049.2_Silent_p.L1505L|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000325971.8_Silent_p.L1384L	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1575										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CAACAGAACTATCAACTGTAT	0.313000													15	50					0	0	0.004990	0	0
GAREM	64762	broad.mit.edu	37	18	29867048	29867048	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:29867048C>T	ENST00000399218.4	-	4	1567	c.1512G>A	c.(1510-1512)gtG>gtA	p.V504V	GAREM_ENST00000269209.6_Silent_p.V504V	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		CTGAAGACTTCACTGCTGCTC	0.502000													12	94					0	0	0.020292	0	0
CSMD2	114784	broad.mit.edu	37	1	34174809	34174809	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:34174809G>T	ENST00000373381.4	-	22	3632	c.3456C>A	c.(3454-3456)ccC>ccA	p.P1152P	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Silent_p.P25P	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1112	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAGGAAAGTTGGGGGACAGCA	0.478000													4	26					0.00024832	0.000280238	0.009096	1	0
TNPO3	23534	broad.mit.edu	37	7	128632072	128632072	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:128632072T>C	ENST00000393245.1	-	10	1712	c.1339A>G	c.(1339-1341)Ata>Gta	p.I447V	TNPO3_ENST00000265388.5_Missense_Mutation_p.I447V|TNPO3_ENST00000482320.1_Missense_Mutation_p.I381V|TNPO3_ENST00000471234.1_Missense_Mutation_p.I447V|TNPO3_ENST00000471166.1_Missense_Mutation_p.I447V	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	447					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						CTCTTTGCTATAGCAGCCATG	0.398000													13	44					0	0	0.016723	0	0
SRD5A3	79644	broad.mit.edu	37	4	56236014	56236014	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:56236014G>C	ENST00000264228.4	+	5	941	c.713G>C	c.(712-714)tGt>tCt	p.C238S	SRD5A3-AS1_ENST00000595103.1_RNA|SRD5A3-AS1_ENST00000595734.1_RNA|SRD5A3-AS1_ENST00000510637.1_RNA|SRD5A3-AS1_ENST00000598906.1_RNA|SRD5A3-AS1_ENST00000596312.1_RNA|SRD5A3_ENST00000514398.1_3'UTR|SRD5A3-AS1_ENST00000433175.2_RNA|SRD5A3-AS1_ENST00000596289.1_RNA	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	238					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GTCATTCACTGTAACCACAGG	0.408000													23	47					0	0	0.005443	0	0
LRRC9	341883	broad.mit.edu	37	14	60465944	60465944	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:60465944G>T	ENST00000445360.1	+	19	2733	c.2529_splice	c.e19+1	p.Q843_splice	RP11-16B13.1_ENST00000555432.1_RNA|RP11-16B13.1_ENST00000554123.1_RNA																							GGATTACTCAGGTTGGATTTT	0.323000													8	23					0.000673444	0.000733603	0.008291	1	0
PTCH1	5727	broad.mit.edu	37	9	98242852	98242852	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:98242852C>A	ENST00000430669.2	-	6	1152	c.567G>T	c.(565-567)cgG>cgT	p.R189R	PTCH1_ENST00000331920.6_Silent_p.R255R|PTCH1_ENST00000437951.1_Silent_p.R189R|PTCH1_ENST00000421141.1_Silent_p.R104R|PTCH1_ENST00000429896.2_Silent_p.R104R|PTCH1_ENST00000548379.1_5'UTR|PTCH1_ENST00000375274.2_Silent_p.R254R|PTCH1_ENST00000418258.1_Silent_p.R104R			Q13635	PTC1_HUMAN	patched 1	255					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AGTTTGTCCACCGCAAAGGAG	0.458000													27	73					5.60225e-13	8.53954e-13	0.009535	1	0
DNAH7	56171	broad.mit.edu	37	2	196892698	196892698	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:196892698C>A	ENST00000312428.6	-	6	572	c.472G>T	c.(472-474)Gag>Tag	p.E158*	DNAH7_ENST00000410072.1_Nonsense_Mutation_p.E158*	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	158	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGTCTTTCTCTATAGCAGAA	0.378000													38	75					2.64514e-33	4.85864e-33	0.014410	1	0
CCDC6	8030	broad.mit.edu	37	10	61665930	61665930	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:61665930T>C	ENST00000263102.6	-	1	484	c.253A>G	c.(253-255)Aag>Gag	p.K85E		NM_005436.4	NP_005427.2	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	85						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton		CCDC6/RET(4)	breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|stomach(1)	18				Kidney(211;0.0597)		TGCAGTGCCTTGCACTTCAGT	0.667000			T	RET	NSCLC								10	17					0	0	0.008291	0	0
USH2A	7399	broad.mit.edu	37	1	215901465	215901465	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:215901465G>T	ENST00000366943.2	-	61	12359	c.11973C>A	c.(11971-11973)ccC>ccA	p.P3991P	USH2A_ENST00000307340.3_Silent_p.P3991P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3991	Fibronectin type-III 25.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAATGCCATTGGGAGATTCTG	0.493000										HNSCC(13;0.011)			27	89					3.73148e-12	5.59085e-12	0.007291	1	0
RYR2	6262	broad.mit.edu	37	1	237670056	237670056	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:237670056A>T	ENST00000366574.2	+	23	2977	c.2660A>T	c.(2659-2661)gAg>gTg	p.E887V	RYR2_ENST00000360064.6_Missense_Mutation_p.E885V|RYR2_ENST00000542537.1_Missense_Mutation_p.E871V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	887	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAACTGGCAGAGAATATCCAT	0.333000													10	27					0	0	0.016723	0	0
EPS8L3	79574	broad.mit.edu	37	1	110294630	110294630	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:110294630C>T	ENST00000369805.3	-	15	1653	c.1424G>A	c.(1423-1425)gGa>gAa	p.G475E	EPS8L3_ENST00000361965.4_Missense_Mutation_p.G474E|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Missense_Mutation_p.G444E	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	474	SH3.					cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CAGCTTCTCTCCCTGGACCAC	0.587000													5	60					0	0	0.001984	0	0
XKR6	286046	broad.mit.edu	37	8	10755724	10755724	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:10755724G>A	ENST00000416569.2	-	3	1690	c.1664C>T	c.(1663-1665)aCg>aTg	p.T555M	XKR6_ENST00000304437.2_Missense_Mutation_p.T276M	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	555						integral to membrane		p.T555M(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		AGTGTCAGCCGTGAGATCCTC	0.612000													21	28					0	0	0.007291	0	0
OR2T3	343173	broad.mit.edu	37	1	248637472	248637472	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:248637472A>G	ENST00000359594.2	+	1	846	c.821A>G	c.(820-822)gAg>gGg	p.E274G		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACACAGCTGAGCAGGACATG	0.537000													54	367					0	0	0.014410	0	0
OR6C74	254783	broad.mit.edu	37	12	55641839	55641839	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:55641839G>C	ENST00000343870.4	+	1	858	c.768G>C	c.(766-768)atG>atC	p.M256I		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						GCATCTTCATGTATGTGAAAC	0.398000													20	39					0	0	0.014323	0	0
PIK3R5	23533	broad.mit.edu	37	17	8791675	8791675	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:8791675G>A	ENST00000447110.1	-	10	1553	c.1429C>T	c.(1429-1431)Cgc>Tgc	p.R477C	PIK3R5_ENST00000581552.1_Missense_Mutation_p.R477C|PIK3R5_ENST00000584803.1_Missense_Mutation_p.R477C	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	477					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GGCAGGGAGCGGGAGCGCTGG	0.721000													4	4					0	0	0.009096	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140782984	140782984	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140782984A>G	ENST00000573521.1	+	1	465	c.465A>G	c.(463-465)ccA>ccG	p.P155P	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCACTTCCAGAAGCTATTG	0.502000													15	37					0	0	0.008871	0	0
GPR61	83873	broad.mit.edu	37	1	110086427	110086427	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:110086427C>A	ENST00000527748.1	+	2	1466	c.783C>A	c.(781-783)agC>agA	p.S261R	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	261						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTCTCAGCAGCCGCTCCACGA	0.682000													10	2					6.31663e-08	8.26527e-08	0.003163	1	0
TTN	7273	broad.mit.edu	37	2	179582523	179582523	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:179582523G>T	ENST00000589042.1	-	87	25302	c.25078C>A	c.(25078-25080)Cct>Act	p.P8360T	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P7116T|TTN_ENST00000591111.1_Missense_Mutation_p.P8043T|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8043	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAGAAAGGTGGAAGTTTG	0.388000													10	23					0.000673444	0.000733603	0.008291	1	0
LINC00842	643650	broad.mit.edu	37	10	47133427	47133427	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:47133427C>A	ENST00000422732.2	-	0	435					NR_033957.1																						CCTCCATTGCCACAGGGGCCA	0.458000													10	46					1.61879e-10	2.33766e-10	0.013537	1	0
DOCK4	9732	broad.mit.edu	37	7	111423968	111423968	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:111423968C>A	ENST00000428084.1	-	34	3741	c.3469G>T	c.(3469-3471)Ggc>Tgc	p.G1157C	DOCK4_ENST00000437633.1_Missense_Mutation_p.G1148C|DOCK4_ENST00000494651.2_Missense_Mutation_p.G31C			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1148	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				AATGAAACGCCACTTTCCCGC	0.408000													5	14					2.7689e-08	3.71726e-08	0.001984	1	0
HSPA6	3310	broad.mit.edu	37	1	161495421	161495421	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:161495421G>C	ENST00000309758.4	+	1	1386	c.973G>C	c.(973-975)Gat>Cat	p.D325H		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	325					response to unfolded protein		ATP binding	p.D325N(1)		endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GGCCCTGCGGGATGCCAAGCT	0.617000													3	14					0	0	0.001168	0	0
GKN2	200504	broad.mit.edu	37	2	69173488	69173488	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:69173488C>G	ENST00000481498.1	-	5	438	c.420G>C	c.(418-420)gaG>gaC	p.E140D	GKN2_ENST00000328895.4_Missense_Mutation_p.E140D			Q86XP6	GKN2_HUMAN	gastrokine 2	140	BRICHOS.					extracellular region				autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	15						TGCAGAGTTTCTCAATGGGTG	0.438000													43	104					0	0	0.014410	0	0
OR2T2	401992	broad.mit.edu	37	1	248616444	248616444	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:248616444C>A	ENST00000342927.3	+	1	368	c.346C>A	c.(346-348)Ctg>Atg	p.L116M		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTCTTCCTGCTGGGTCTCAT	0.552000													6	92					0.00621372	0.00654154	0.006214	1	0
TWSG1	57045	broad.mit.edu	37	18	9360051	9360051	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:9360051G>C	ENST00000262120.5	+	3	396	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	TWSG1_ENST00000581641.1_Missense_Mutation_p.E69Q	NM_020648.5	NP_065699.1	Q9GZX9	TWSG1_HUMAN	twisted gastrulation BMP signaling modulator 1	69	Cys-rich.									breast(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|pancreas(2)	10						CCTTTGGGACGAGTGCTGTGA	0.463000													13	50					0	0	0.004007	0	0
SPAG17	200162	broad.mit.edu	37	1	118550775	118550775	+	Silent	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:118550775T>C	ENST00000336338.5	-	31	4544	c.4479A>G	c.(4477-4479)gtA>gtG	p.V1493V		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1493						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GTGAGCTTTCTACCCGCATAC	0.493000													12	30					0	0	0.016723	0	0
RPE65	6121	broad.mit.edu	37	1	68895602	68895602	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:68895602G>T	ENST00000262340.5	-	14	1512	c.1459C>A	c.(1459-1461)Ctg>Atg	p.L487M		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	487					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ACCACACTCAGAACTACACCT	0.408000													11	22					0.000673444	0.000733603	0.008291	1	0
AQR	9716	broad.mit.edu	37	15	35198859	35198859	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:35198859T>A	ENST00000156471.5	-	18	1943	c.1718A>T	c.(1717-1719)tAt>tTt	p.Y573F		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	573						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CTTAGTGCCATAAGGTTTTGT	0.393000													16	78					0	0	0.004007	0	0
MUC16	94025	broad.mit.edu	37	19	9065829	9065829	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:9065829G>A	ENST00000397910.4	-	3	21820	c.21617C>T	c.(21616-21618)tCc>tTc	p.S7206F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7208	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGGCTTTGGATGTCTCTGA	0.488000													64	103					0	0	0.014410	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176248	140176248	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:140176248G>T	ENST00000526136.1	+	1	1699	c.1699G>T	c.(1699-1701)Gcg>Tcg	p.A567S	PCDHA2_ENST00000520672.2_Missense_Mutation_p.A567S|PCDHA2_ENST00000378132.1_Missense_Mutation_p.A567S|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCACTGTTGGCGCCTAGGGC	0.701000													5	41					0.00198382	0.00211897	0.001984	1	0
AIM1	202	broad.mit.edu	37	6	106975228	106975228	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:106975228A>G	ENST00000369066.3	+	5	3724	c.3237A>G	c.(3235-3237)ttA>ttG	p.L1079L		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1079	Beta/gamma crystallin 'Greek key' 2.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CCATCCCCTTAGAAGAAGGAG	0.423000													22	73					0	0	0.021523	0	0
OR52L1	338751	broad.mit.edu	37	11	6007733	6007733	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:6007733G>T	ENST00000332249.4	-	1	482	c.428C>A	c.(427-429)gCc>gAc	p.A143D		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGACAAATGGCTACATAGCA	0.522000													20	38					1.5548e-18	2.59035e-18	0.005443	1	0
FMN2	56776	broad.mit.edu	37	1	240370180	240370180	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:240370180A>G	ENST00000319653.9	+	5	2298	c.2068A>G	c.(2068-2070)Ata>Gta	p.I690V		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	690					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGAACCAAAATAGCTGAACT	0.512000													5	14					0	0	0.004482	0	0
PAPPA	5069	broad.mit.edu	37	9	118974078	118974078	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:118974078G>A	ENST00000328252.3	+	4	2154	c.1785G>A	c.(1783-1785)gaG>gaA	p.E595E	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	595					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CCTCCTTCGAGACTGGAGACC	0.542000													62	157					0	0	0.014410	0	0
HIP1	3092	broad.mit.edu	37	7	75191462	75191462	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:75191462T>A	ENST00000336926.6	-	12	1059	c.1033A>T	c.(1033-1035)Aac>Tac	p.N345Y	HIP1_ENST00000434438.2_Missense_Mutation_p.N345Y	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	345					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TCAAACTTGTTGTCAAATAAA	0.428000			T	PDGFRB	CMML								13	27					0	0	0.004990	0	0
ADAM20	8748	broad.mit.edu	37	14	70990727	70990727	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:70990727C>A	ENST00000256389.3	-	2	1142	c.898G>T	c.(898-900)Gtt>Ttt	p.V300F	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	250	Peptidase M12B.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ATTACATCAACCTCCAAAGGA	0.343000													27	90					2.12542e-12	3.2119e-12	0.006320	1	0
IGHV3OR15-7	28318	broad.mit.edu	37	15	20193188	20193188	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:20193188C>A	ENST00000558565.2	-	0	79																											CAAGCCTCCCCCAGACTCCAC	0.562000													45	96					6.3237e-29	1.1285e-28	0.014410	1	0
C11orf30	56946	broad.mit.edu	37	11	76257297	76257297	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:76257297G>A	ENST00000529032.1	+	19	3730	c.3730G>A	c.(3730-3732)Ggc>Agc	p.G1244S	C11orf30_ENST00000533248.1_Missense_Mutation_p.G1153S|C11orf30_ENST00000524490.1_Missense_Mutation_p.G1146S|C11orf30_ENST00000334736.3_Missense_Mutation_p.G1244S|C11orf30_ENST00000524767.1_Missense_Mutation_p.G1259S|C11orf30_ENST00000525919.1_Missense_Mutation_p.G1245S|C11orf30_ENST00000525038.1_Missense_Mutation_p.G1245S|C11orf30_ENST00000343878.3_Intron			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1244					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						TCAGAATGTAGGCCAAAAGAA	0.463000													9	50					0	0	0.013537	0	0
KCNA10	3744	broad.mit.edu	37	1	111060823	111060823	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:111060823T>C	ENST00000369771.2	-	1	974	c.587A>G	c.(586-588)aAt>aGt	p.N196S		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	196						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GTGGATGTCATTGGTGGGTAG	0.547000													15	33					0	0	0.018920	0	0
PRKAR1B	5575	broad.mit.edu	37	7	751061	751061	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:751061G>T	ENST00000406797.1	-	2	256	c.82C>A	c.(82-84)Cag>Aag	p.Q28K	PRKAR1B_ENST00000537384.1_Missense_Mutation_p.Q28K|PRKAR1B_ENST00000488474.1_5'UTR|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.Q28K|PRKAR1B_ENST00000403562.1_Missense_Mutation_p.Q28K|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.Q28K	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	28	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		AGGACCTGCTGGATCCCGTGC	0.637000													19	39					5.35356e-11	7.79506e-11	0.016522	1	0
GPR78	27201	broad.mit.edu	37	4	8588829	8588829	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:8588829C>A	ENST00000382487.4	+	3	1248	c.831C>A	c.(829-831)atC>atA	p.I277I	GPR78_ENST00000509216.1_3'UTR	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	277					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						AGTGGGGCATCCTCAGCAAGT	0.662000													3	3					0.00024832	0.000280238	0.009096	1	0
NAV3	89795	broad.mit.edu	37	12	78522559	78522559	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:78522559C>T	ENST00000397909.2	+	18	4527	c.4354C>T	c.(4354-4356)Ctt>Ttt	p.L1452F	NAV3_ENST00000536525.2_Missense_Mutation_p.L1452F|NAV3_ENST00000266692.7_Missense_Mutation_p.L1275F|NAV3_ENST00000228327.6_Missense_Mutation_p.L1452F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1452	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TACTGGAGGGCTTCAGGACAC	0.473000										HNSCC(70;0.22)			17	34					0	0	0.008871	0	0
XKRX	402415	broad.mit.edu	37	X	100183300	100183300	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:100183300G>T	ENST00000328526.5	-	1	598	c.33C>A	c.(31-33)acC>acA	p.T11T	XKRX_ENST00000372956.2_5'UTR|XKRX_ENST00000468904.1_5'UTR	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	0						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						CCATTGTCGAGGTTCTTTCTG	0.498000													101	329					1.98007e-57	3.74678e-57	0.014410	1	0
PCLO	27445	broad.mit.edu	37	7	82595465	82595465	+	Silent	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:82595465T>G	ENST00000423517.2	-	4	3976	c.3639A>C	c.(3637-3639)ccA>ccC	p.P1213P	PCLO_ENST00000333891.8_Silent_p.P1213P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1152					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTCAGGGAGTGGCTTTTTTT	0.358000													6	96					0	0	0.001168	0	0
USP26	83844	broad.mit.edu	37	X	132161731	132161731	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:132161731G>C	ENST00000511190.1	-	6	987	c.518C>G	c.(517-519)tCa>tGa	p.S173*	USP26_ENST00000370832.1_Nonsense_Mutation_p.S173*|USP26_ENST00000406273.1_Nonsense_Mutation_p.S173*	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	173					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					CTGATTTTCTGATAACTCTCC	0.378000													26	54					0	0	0.005443	0	0
LAMB4	22798	broad.mit.edu	37	7	107704278	107704278	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:107704278T>A	ENST00000388781.3	-	22	3072	c.2989A>T	c.(2989-2991)Aac>Tac	p.N997Y	LAMB4_ENST00000388780.3_Missense_Mutation_p.N997Y|LAMB4_ENST00000205386.4_Missense_Mutation_p.N997Y	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	997	Laminin EGF-like 10.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CCCTGAGTGTTGTGCAAACAT	0.532000													30	70					0	0	0.012213	0	0
SPZ1	84654	broad.mit.edu	37	5	79616477	79616477	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:79616477C>A	ENST00000296739.4	+	1	688	c.443C>A	c.(442-444)aCc>aAc	p.T148N		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		ATATTGGAAACCAATATTACT	0.373000													18	46					1.96292e-10	2.8207e-10	0.010504	1	0
CRB1	23418	broad.mit.edu	37	1	197404272	197404272	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:197404272G>T	ENST00000367397.1	+	5	2280	c.1422G>T	c.(1420-1422)ctG>ctT	p.L474L	CRB1_ENST00000544212.1_Silent_p.L574L|CRB1_ENST00000367400.3_Silent_p.L1093L|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000535699.1_Silent_p.L1069L|CRB1_ENST00000367399.2_Silent_p.L981L			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1093	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TAAAGGGCCTGCAAGGGTGTC	0.373000													13	42					6.31663e-08	8.26527e-08	0.003163	1	0
RYR1	6261	broad.mit.edu	37	19	38976291	38976291	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:38976291C>A	ENST00000355481.4	+	34	5127	c.4996C>A	c.(4996-4998)Ctg>Atg	p.L1666M	RYR1_ENST00000360985.3_Missense_Mutation_p.L1666M|RYR1_ENST00000359596.3_Missense_Mutation_p.L1666M	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1666	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTCGCACACCCTGCGCCTCTA	0.642000													10	15					1.55795e-14	2.44264e-14	0.012319	1	0
APC	324	broad.mit.edu	37	5	112177307	112177307	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:112177307G>C	ENST00000457016.1	+	16	6396	c.6016G>C	c.(6016-6018)Ggc>Cgc	p.G2006R	APC_ENST00000508376.2_Missense_Mutation_p.G2006R|CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Missense_Mutation_p.G2006R			P25054	APC_HUMAN	adenomatous polyposis coli	2006	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCAAGCatcaggctatgctcc	0.403000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			6	69					0	0	0.001168	0	0
ZNF571	51276	broad.mit.edu	37	19	38055807	38055807	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:38055807T>A	ENST00000328550.2	-	4	1622	c.1523A>T	c.(1522-1524)gAc>gTc	p.D508V	ZNF571-AS1_ENST00000592392.1_RNA|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.D508V|ZNF571-AS1_ENST00000589802.1_RNA|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571_ENST00000590751.1_Intron|ZNF571-AS1_ENST00000586013.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.D508V|ZNF571_ENST00000451802.2_Missense_Mutation_p.D508V			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAGGCCTTGTCACATTCCTT	0.378000													22	56					0	0	0.005443	0	0
IGSF11	152404	broad.mit.edu	37	3	118621691	118621691	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:118621691G>T	ENST00000354673.2	-	9	1349	c.969C>A	c.(967-969)aaC>aaA	p.N323K	IGSF11_ENST00000491903.1_Missense_Mutation_p.N296K|IGSF11_ENST00000393775.2_Missense_Mutation_p.N324K|IGSF11_ENST00000441144.2_Missense_Mutation_p.N299K|IGSF11_ENST00000425327.2_Missense_Mutation_p.N323K|IGSF11_ENST00000489689.1_Missense_Mutation_p.N300K	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	324					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CTTTTGGATTGTTGCTCCAGT	0.448000													42	85					2.76378e-25	4.8825e-25	0.014410	1	0
RYR2	6262	broad.mit.edu	37	1	237617851	237617851	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:237617851C>A	ENST00000366574.2	+	15	1770	c.1453C>A	c.(1453-1455)Cgg>Agg	p.R485R	RYR2_ENST00000360064.6_Silent_p.R483R|RYR2_ENST00000542537.1_Silent_p.R469R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	485					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTGAAGAATCGGCAAAATCT	0.433000													30	39					2.75727e-19	4.62001e-19	0.021022	1	0
KRT40	125115	broad.mit.edu	37	17	39140293	39140293	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:39140293G>T	ENST00000377755.4	-	1	267	c.233C>A	c.(232-234)gCc>gAc	p.A78D	KRT40_ENST00000398486.2_Missense_Mutation_p.A78D			Q6A162	K1C40_HUMAN	keratin 40	78	Head.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				CTCACACCAGGCACAGTTCCC	0.552000													49	129					1.74971e-23	3.04207e-23	0.014410	1	0
FGL2	10875	broad.mit.edu	37	7	76826210	76826210	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:76826210T>A	ENST00000248598.5	-	2	738	c.706A>T	c.(706-708)Agt>Tgt	p.S236C	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron|RP11-467H10.2_ENST00000459742.1_RNA	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	236	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TCAAAGCTACTATTTTTGGGA	0.468000													20	44					0	0	0.014323	0	0
NPAP1	23742	broad.mit.edu	37	15	24923002	24923002	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:24923002G>T	ENST00000329468.2	+	1	2462	c.1988G>T	c.(1987-1989)aGt>aTt	p.S663I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCTCTCCCCAGTGCCTGTGTT	0.502000													16	48					5.03518e-11	7.35589e-11	0.007413	1	0
NXPH2	11249	broad.mit.edu	37	2	139429201	139429201	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:139429201G>T	ENST00000272641.3	-	2	192	c.86C>A	c.(85-87)aCg>aAg	p.T29K		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	29	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CAGCCCCTCCGTGGCATGCAC	0.488000													25	63					5.7616e-29	1.03028e-28	0.014410	1	0
TTLL2	83887	broad.mit.edu	37	6	167754758	167754758	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:167754758C>T	ENST00000239587.5	+	3	1458	c.1370C>T	c.(1369-1371)tCt>tTt	p.S457F		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	457					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCTTATGATTCTCTTTCGTTC	0.507000													20	28					0	0	0.016522	0	0
FRG1B	284802	broad.mit.edu	37	20	29632664	29632664	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:29632664G>C	ENST00000278882.3	+	8	859	c.479G>C	c.(478-480)aGt>aCt	p.S160T	FRG1B_ENST00000358464.4_Missense_Mutation_p.S160T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAAGAAGAGAGTAAAATTCTT	0.313000													7	429					0	0	0.008291	0	0
LARP1B	55132	broad.mit.edu	37	4	128998985	128998985	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:128998985A>G	ENST00000326639.6	+	4	296	c.85A>G	c.(85-87)Aga>Gga	p.R29G	LARP1B_ENST00000427266.1_Missense_Mutation_p.R29G|LARP1B_ENST00000394288.3_Missense_Mutation_p.R29G|LARP1B_ENST00000512292.1_Missense_Mutation_p.R29G|LARP1B_ENST00000432347.2_Missense_Mutation_p.R29G|LARP1B_ENST00000264584.5_Missense_Mutation_p.R29G|LARP1B_ENST00000354456.3_5'UTR|LARP1B_ENST00000441387.1_Missense_Mutation_p.R29G	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	29							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						GCCACAAAATAGAAAAGAAAA	0.358000													8	17					0	0	0.016723	0	0
MUC17	140453	broad.mit.edu	37	7	100685357	100685357	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:100685357G>C	ENST00000306151.4	+	3	10724	c.10660G>C	c.(10660-10662)Gcc>Ccc	p.A3554P		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3554	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TTCTAGTCAAGCCAGTTCATC	0.473000													20	33					0	0	0.012319	0	0
PMS2	5395	broad.mit.edu	37	7	6029498	6029498	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:6029498C>G	ENST00000265849.7	-	10	1182	c.1077G>C	c.(1075-1077)ttG>ttC	p.L359F	PMS2_ENST00000469652.1_Intron|PMS2_ENST00000441476.2_Missense_Mutation_p.L253F|PMS2_ENST00000406569.3_Missense_Mutation_p.L359F|PMS2_ENST00000382321.4_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	359					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		ACATTCCTATCAAAGAGGTCT	0.363000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				6	22					0	0	0.001168	0	0
TSHZ1	10194	broad.mit.edu	37	18	72999442	72999442	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:72999442G>T	ENST00000322038.5	+	2	2529	c.1945G>T	c.(1945-1947)Ggc>Tgc	p.G649C	TSHZ1_ENST00000580243.1_Missense_Mutation_p.G694C	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	694						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACAGAAGAAGGGCCCTGAGGC	0.562000													13	25					6.49762e-13	9.88719e-13	0.006122	1	0
TMEM132A	54972	broad.mit.edu	37	11	60695130	60695130	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:60695130C>T	ENST00000005286.4	+	3	486	c.333C>T	c.(331-333)gtC>gtT	p.V111V	TMEM132A_ENST00000453848.2_Silent_p.V111V	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	111						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CCCCTCGAGTCACTGAGCCCC	0.612000													8	19					0	0	0.004482	0	0
TGM5	9333	broad.mit.edu	37	15	43525419	43525419	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:43525419G>T	ENST00000220420.5	-	13	2140	c.2133C>A	c.(2131-2133)taC>taA	p.Y711*	TGM5_ENST00000349114.4_Nonsense_Mutation_p.Y629*	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	711					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	AAACATTCCTGTAACCCTTAA	0.423000													13	22					7.93312e-07	9.97891e-07	0.020292	1	0
C4orf21	55345	broad.mit.edu	37	4	113524814	113524814	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:113524814T>A	ENST00000505019.1	-	10	2967	c.2842A>T	c.(2842-2844)Act>Tct	p.T948S	C4orf21_ENST00000309071.5_Missense_Mutation_p.T948S	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	948										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ACACCACTAGTAGCTGATCCT	0.373000													9	27					0	0	0.016723	0	0
DENND2C	163259	broad.mit.edu	37	1	115144127	115144127	+	Splice_Site	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:115144127A>T	ENST00000393274.1	-	13	2441		c.e13+1		DENND2C_ENST00000393276.3_Splice_Site|DENND2C_ENST00000393277.1_Splice_Site|DENND2C_ENST00000481894.1_Splice_Site	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C											NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTCCACTCACCTTTGAAAA	0.393000													108	199					0	0	0.014410	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948296	82948296	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:82948296C>G	ENST00000274341.4	-	3	1298	c.448G>C	c.(448-450)Gtt>Ctt	p.V150L	HAPLN1_ENST00000514416.1_Missense_Mutation_p.V150L	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	150	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GCTACCACAACAGTATCATCT	0.373000													8	56					0	0	0.013537	0	0
ABCC11	85320	broad.mit.edu	37	16	48201239	48201239	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:48201239C>T	ENST00000394747.1	-	29	4444	c.4095G>A	c.(4093-4095)aaG>aaA	p.K1365K	ABCC11_ENST00000356608.2_Silent_p.K1365K|ABCC11_ENST00000353782.5_Silent_p.K1327K|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000394748.1_Silent_p.K1365K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1365	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATGACCCAGGCTTCTTCCGCA	0.562000													8	56					0	0	0.010729	0	0
GRIK2	2898	broad.mit.edu	37	6	102074322	102074322	+	Silent	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:102074322A>T	ENST00000369138.1	+	3	841	c.351A>T	c.(349-351)gcA>gcT	p.A117A	GRIK2_ENST00000369134.4_Silent_p.A68A|GRIK2_ENST00000421544.1_Silent_p.A117A|GRIK2_ENST00000358361.3_Silent_p.A117A|GRIK2_ENST00000369137.3_Silent_p.A117A|GRIK2_ENST00000318991.6_Silent_p.A117A|GRIK2_ENST00000413795.1_Silent_p.A117A	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	117					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CAGCAAACGCAGTGCAGTCCA	0.517000													43	106					0	0	0.010771	0	0
SRGAP2B	647135	broad.mit.edu	37	1	144014034	144014034	+	RNA	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:144014034G>T	ENST00000467933.1	+	0	1049																											CCCGCAACCTGGAGAAGCTGG	0.542000													4	19					0.00024832	0.000280238	0.009096	1	0
ALS2CR12	130540	broad.mit.edu	37	2	202211399	202211399	+	Splice_Site	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:202211399C>G	ENST00000405148.2	-	5	678		c.e5-1		ALS2CR12_ENST00000439709.1_Splice_Site|ALS2CR12_ENST00000286190.5_Splice_Site|ALS2CR12_ENST00000448967.1_Splice_Site|ALS2CR12_ENST00000392257.3_Splice_Site	NM_139163.2	NP_631902.2	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12						regulation of GTPase activity		protein binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)	21						TGATCACTTCCTAGGCATCAA	0.438000													53	168					0	0	0.014410	0	0
FAT1	2195	broad.mit.edu	37	4	187532546	187532546	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:187532546T>A	ENST00000441802.2	-	14	10056	c.9847A>T	c.(9847-9849)Aaa>Taa	p.K3283*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3283	Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTACCTGTTTTAGAATCTATG	0.388000										HNSCC(5;0.00058)			19	41					0	0	0.007413	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45204300	45204300	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:45204300A>G	ENST00000361473.5	+	7	916	c.674A>G	c.(673-675)tAc>tGc	p.Y225C	ARHGAP8_ENST00000517296.3_Intron|ARHGAP8_ENST00000336963.4_Missense_Mutation_p.Y94C|ARHGAP8_ENST00000389774.2_Missense_Mutation_p.Y94C|ARHGAP8_ENST00000389773.5_Missense_Mutation_p.Y216C|ARHGAP8_ENST00000356099.6_Missense_Mutation_p.Y94C|PRR5-ARHGAP8_ENST00000352766.7_Intron																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						CAGAGCGCATACAAGGAGTTC	0.567000													6	9					0	0	0.001984	0	0
CLIP2	7461	broad.mit.edu	37	7	73753320	73753320	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:73753320G>T	ENST00000223398.6	+	3	991	c.664G>T	c.(664-666)Ggg>Tgg	p.G222W	CLIP2_ENST00000361545.5_Missense_Mutation_p.G222W|CLIP2_ENST00000395060.1_Missense_Mutation_p.G222W	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	222						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						CCTGCGCCTGGGGGACCGCGT	0.672000													5	10					2.74318e-10	3.93548e-10	0.006214	1	0
OR2A12	346525	broad.mit.edu	37	7	143792345	143792345	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:143792345T>C	ENST00000408949.2	+	1	205	c.145T>C	c.(145-147)Tac>Cac	p.Y49H		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					GGGGCTCATCTACTTGGACTC	0.493000													29	92					0	0	0.013726	0	0
EYA1	2138	broad.mit.edu	37	8	72229803	72229803	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:72229803G>A	ENST00000340726.3	-	7	1179	c.540C>T	c.(538-540)taC>taT	p.Y180Y	EYA1_ENST00000388743.2_Silent_p.Y179Y|EYA1_ENST00000388742.4_Silent_p.Y180Y|EYA1_ENST00000388741.2_Silent_p.Y146Y|EYA1_ENST00000419131.1_Silent_p.Y175Y|EYA1_ENST00000388740.3_Silent_p.Y147Y|EYA1_ENST00000303824.7_Silent_p.Y174Y	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	180					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TCTGGTAGCTGTATGGTGCCT	0.438000													40	120					0	0	0.014410	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967314	142967314	+	Missense_Mutation	SNP	G	G	T	rs146025392		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:142967314G>T	ENST00000370494.1	+	1	142	c.112G>T	c.(112-114)Gtc>Ttc	p.V38F		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	38							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTCATGTGGTCATTGCTGG	0.493000													66	108					5.22007e-41	9.77233e-41	0.014410	1	0
PTPRD	5789	broad.mit.edu	37	9	8340469	8340469	+	Splice_Site	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:8340469T>C	ENST00000381196.4	-	39	5670	c.5126_splice	c.e39-1	p.R1709_splice	PTPRD_ENST00000397617.3_Splice_Site_p.R1302_splice|PTPRD_ENST00000540109.1_Splice_Site_p.R1709_splice|PTPRD_ENST00000360074.4_Splice_Site_p.R1696_splice|PTPRD_ENST00000537002.1_Splice_Site_p.R1299_splice|PTPRD_ENST00000358503.5_Splice_Site_p.R1687_splice|PTPRD_ENST00000355233.5_Splice_Site_p.R1303_splice|PTPRD_ENST00000486161.1_Splice_Site_p.R1302_splice|PTPRD_ENST00000356435.5_Splice_Site_p.R1709_splice|PTPRD_ENST00000397606.3_Splice_Site_p.R1302_splice|PTPRD_ENST00000397611.3_Splice_Site_p.R1299_splice	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1709	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTTCTGTTGTCTGAATTACA	0.423000										TSP Lung(15;0.13)			13	16					0	0	0.003163	0	0
BPI	671	broad.mit.edu	37	20	36959463	36959463	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:36959463C>A	ENST00000262865.4	+	12	1344	c.1255C>A	c.(1255-1257)Ctg>Atg	p.L419M	BPI_ENST00000489102.1_3'UTR	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	419					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GCTCCTGGAACTGAAGCACTC	0.592000													17	46					1.56452e-12	2.37246e-12	0.007413	1	0
KCNH8	131096	broad.mit.edu	37	3	19436595	19436595	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:19436595G>T	ENST00000328405.2	+	7	1235		c.e7-1		KCNH8_ENST00000475063.1_Splice_Site|KCNH8_ENST00000537696.1_Splice_Site	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8							integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TCTTACCACAGGTGTCTCTCG	0.433000													17	27					0.000132079	0.000152185	0.008871	1	0
OTUD7A	161725	broad.mit.edu	37	15	31862380	31862380	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:31862380C>A	ENST00000382902.1	-	2	264	c.172G>T	c.(172-174)Gcc>Tcc	p.A58S	OTUD7A_ENST00000307050.4_Missense_Mutation_p.A58S			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	58						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CTCAGAGCGGCTGTCAGGTCC	0.527000													7	24					0.000274275	0.00030716	0.004482	1	0
CNTN5	53942	broad.mit.edu	37	11	100126553	100126553	+	Silent	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:100126553G>C	ENST00000524871.1	+	17	2357	c.2067G>C	c.(2065-2067)ctG>ctC	p.L689L	CNTN5_ENST00000279463.3_Silent_p.L689L|CNTN5_ENST00000418526.2_Silent_p.L615L|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Silent_p.L689L|CNTN5_ENST00000528682.1_Silent_p.L689L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	689	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CGGCCACACTGTCCTGGAGCC	0.502000													24	40					0	0	0.004656	0	0
CLCN1	1180	broad.mit.edu	37	7	143017866	143017866	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:143017866C>A	ENST00000343257.2	+	3	498	c.411C>A	c.(409-411)taC>taA	p.Y137*		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	137					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GCATGGACTACGTCAGTGCCA	0.537000													64	170					1.77355e-41	3.32731e-41	0.014410	1	0
FSCN1	6624	broad.mit.edu	37	7	5642887	5642887	+	Splice_Site	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:5642887G>A	ENST00000382361.3	+	2	946		c.e2-1		FSCN1_ENST00000340250.6_Splice_Site	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)						actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		CCTCTCTGCAGGTATGGACCT	0.597000													9	12					0	0	0.006214	0	0
F5	2153	broad.mit.edu	37	1	169525952	169525952	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:169525952G>T	ENST00000367796.3	-	6	1085	c.884C>A	c.(883-885)aCc>aAc	p.T295N	F5_ENST00000367797.3_Missense_Mutation_p.T295N|F5_ENST00000546081.1_Missense_Mutation_p.T158N			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	295	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CATATTTGCGGTAGTGGATGT	0.488000													14	27					5.01169e-05	5.84365e-05	0.004990	1	0
TXLNB	167838	broad.mit.edu	37	6	139564275	139564275	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:139564275G>T	ENST00000358430.3	-	10	1675	c.1443C>A	c.(1441-1443)aaC>aaA	p.N481K	RP1-225E12.3_ENST00000585874.1_RNA	NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	481						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CCACAGAGACGTTTGACTCTG	0.438000													17	65					3.32936e-07	4.26741e-07	0.006122	1	0
NDUFS1	4719	broad.mit.edu	37	2	207011778	207011778	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:207011778C>T	ENST00000233190.5	-	8	852	c.586G>A	c.(586-588)Gga>Aga	p.G196R	NDUFS1_ENST00000423725.1_Missense_Mutation_p.G139R|NDUFS1_ENST00000457011.1_Missense_Mutation_p.G80R|NDUFS1_ENST00000455934.2_Missense_Mutation_p.G210R|NDUFS1_ENST00000449699.1_Missense_Mutation_p.G196R|NDUFS1_ENST00000440274.1_Missense_Mutation_p.G160R|NDUFS1_ENST00000432169.1_Missense_Mutation_p.G85R	NM_005006.6	NP_004997.4	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	196					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(15)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					NADH(DB00157)	CCTGTTGTTCCCAAATCATCT	0.378000													8	46					0	0	0.004482	0	0
HIPK2	28996	broad.mit.edu	37	7	139258034	139258034	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:139258034C>A	ENST00000406875.3	-	15	3330	c.3236G>T	c.(3235-3237)aGc>aTc	p.S1079I	HIPK2_ENST00000428878.2_Missense_Mutation_p.S1052I	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	1079	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					AGTGCCGTGGCTGGGGCTGTT	0.697000													6	7					3.07112e-06	3.80316e-06	0.010729	1	0
TRABD2A	129293	broad.mit.edu	37	2	85097822	85097822	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:85097822C>A	ENST00000335459.5	-	2	401	c.196G>T	c.(196-198)Gtt>Ttt	p.V66F	TRABD2A_ENST00000409520.2_Missense_Mutation_p.V66F|TRABD2A_ENST00000409133.1_Missense_Mutation_p.V66F	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		AAGTCCCAAACTCGGGTGTAC	0.483000													5	5					0.000157383	0.000179691	0.003080	1	0
SLC22A3	6581	broad.mit.edu	37	6	160858143	160858143	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:160858143G>T	ENST00000392145.1	+	7	1215	c.1188G>T	c.(1186-1188)ttG>ttT	p.L396F	SLC22A3_ENST00000275300.2_Missense_Mutation_p.L396F			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	396						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GAGCTCTCTTGATCTTACTAA	0.522000													5	118					5.18039e-06	6.3348e-06	0.003080	1	0
CMKLR1	1240	broad.mit.edu	37	12	108686401	108686401	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:108686401C>A	ENST00000397688.2	-	3	702	c.333G>T	c.(331-333)aaG>aaT	p.K111N	CMKLR1_ENST00000312143.7_Missense_Mutation_p.K113N|CMKLR1_ENST00000552995.1_Missense_Mutation_p.K111N|CMKLR1_ENST00000412676.1_Missense_Mutation_p.K113N|CMKLR1_ENST00000550402.1_Missense_Mutation_p.K113N	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	113					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						AGTTGCTGATCTTGCACATGG	0.532000													10	44					6.33239e-15	9.9997e-15	0.010504	1	0
RAB3C	115827	broad.mit.edu	37	5	58120941	58120941	+	Nonsense_Mutation	SNP	G	G	T	rs140644565		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:58120941G>T	ENST00000282878.4	+	4	617	c.448G>T	c.(448-450)Gag>Tag	p.E150*		NM_138453.2	NP_612462.1	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	150					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding	p.E150K(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)	21		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CATGGAAGACGAGCGGGTCAT	0.363000													20	74					1.33986e-20	2.29318e-20	0.004656	1	0
PTPRU	10076	broad.mit.edu	37	1	29605971	29605971	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:29605971A>T	ENST00000356870.3	+	10	1677	c.1567A>T	c.(1567-1569)Agc>Tgc	p.S523C	PTPRU_ENST00000460170.2_Missense_Mutation_p.S523C|PTPRU_ENST00000345512.3_Missense_Mutation_p.S523C|PTPRU_ENST00000323874.8_Missense_Mutation_p.S523C|PTPRU_ENST00000428026.2_Missense_Mutation_p.S523C|PTPRU_ENST00000373779.3_Missense_Mutation_p.S523C	NM_133177.3	NP_573438.3	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	523	Fibronectin type-III 3.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCCCCAGATCAGCTACCAGAG	0.587000													4	29					0	0	0.001168	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79609676	79609676	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:79609676C>T	ENST00000263849.4	+	6	641	c.539C>T	c.(538-540)cCt>cTt	p.P180L	ZC2HC1A_ENST00000521176.1_3'UTR	NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	180																	TCAAATTCTCCTGGAACTGCA	0.363000													16	45					0	0	0.006122	0	0
FAM46D	169966	broad.mit.edu	37	X	79698089	79698089	+	Silent	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:79698089G>A	ENST00000538312.1	+	5	385	c.51G>A	c.(49-51)ctG>ctA	p.L17L	FAM46D_ENST00000308293.5_Silent_p.L17L	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	17										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						TTATAACACTGGATCAAGTGT	0.363000													13	7					0	0	0.013537	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692293	31692293	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:31692293G>A	ENST00000360542.3	-	1	314	c.61C>T	c.(61-63)Cat>Tat	p.H21Y		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	21						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						AGAGGAATATGGCGGGAGGTT	0.532000													24	49					0	0	0.021523	0	0
ESPNP	284729	broad.mit.edu	37	1	17029265	17029265	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:17029265C>A	ENST00000492551.1	-	0	1100					NR_026567.1																						TGTCAGCTGCCTGTGGTCCCA	0.657000													5	47					8.12818e-05	9.39019e-05	0.001984	1	0
COL4A2	1284	broad.mit.edu	37	13	111130465	111130465	+	Silent	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:111130465T>A	ENST00000360467.5	+	30	2847	c.2541T>A	c.(2539-2541)ccT>ccA	p.P847P		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	847	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGGAGCTCCTGGCCAAGAGG	0.657000													4	1					0	0	0.009096	0	0
HCRTR1	3061	broad.mit.edu	37	1	32085306	32085306	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:32085306C>A	ENST00000403528.2	+	4	758	c.373C>A	c.(373-375)Cta>Ata	p.L125I	HCRTR1_ENST00000468521.1_Intron|HCRTR1_ENST00000373705.1_Missense_Mutation_p.L125I|HCRTR1_ENST00000373706.5_Missense_Mutation_p.L125I	NM_001525.2	NP_001516.2	O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	125					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CATCCCCTATCTACAGGTGAG	0.587000													8	14					1.12685e-05	1.34609e-05	0.004482	1	0
EGR1	1958	broad.mit.edu	37	5	137803056	137803056	+	Silent	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:137803056C>G	ENST00000239938.4	+	2	1190	c.918C>G	c.(916-918)gcC>gcG	p.A306A		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	306					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCTGAAGGCCCTCAATACCA	0.622000													7	69					0	0	0.010729	0	0
MYO18B	84700	broad.mit.edu	37	22	26173729	26173729	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:26173729T>A	ENST00000335473.7	+	8	2299	c.2049T>A	c.(2047-2049)agT>agA	p.S683R	MYO18B_ENST00000407587.2_Missense_Mutation_p.S683R|MYO18B_ENST00000536101.1_Missense_Mutation_p.S683R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	683	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGGCAGGCAGTGTGGATGGCA	0.597000													10	22					0	0	0.006122	0	0
HMCN1	83872	broad.mit.edu	37	1	186036967	186036967	+	Splice_Site	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:186036967A>G	ENST00000271588.4	+	50	7936	c.7705_splice	c.e50-1	p.V2569_splice	HMCN1_ENST00000367492.2_Splice_Site_p.V2569_splice	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2569					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTTTTTCAGTATCTCCTACAA	0.328000													16	32					0	0	0.004990	0	0
ZNF521	25925	broad.mit.edu	37	18	22806155	22806155	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:22806155T>G	ENST00000361524.3	-	4	1875	c.1727A>C	c.(1726-1728)aAa>aCa	p.K576T	ZNF521_ENST00000584787.1_Missense_Mutation_p.K356T|ZNF521_ENST00000538137.2_Missense_Mutation_p.K576T	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	576					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTTGTTCAGTTTAAGAACGCT	0.418000			T	PAX5	ALL								26	43					0	0	0.010818	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182908311	182908311	+	Splice_Site	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:182908311C>A	ENST00000367547.3	-	5	1312	c.1076_splice	c.e5+1	p.R359_splice	SHCBP1L_ENST00000423786.1_Splice_Site_p.R240_splice|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	431										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						AAATTATTACCGGAGGCGTAA	0.343000													15	25					3.32936e-07	4.26741e-07	0.006122	1	0
NEO1	4756	broad.mit.edu	37	15	73562350	73562350	+	Splice_Site	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:73562350G>T	ENST00000339362.5	+	18	2941		c.e18-1		NEO1_ENST00000560262.1_Splice_Site|NEO1_ENST00000261908.6_Splice_Site|NEO1_ENST00000558964.1_Splice_Site			Q92859	NEO1_HUMAN	neogenin 1						axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TTTCTGCTCAGACACTTCTGA	0.368000													38	141					3.33393e-15	5.2933e-15	0.021022	1	0
MRE11A	4361	broad.mit.edu	37	11	94189495	94189495	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:94189495A>C	ENST00000323929.3	-	14	1732	c.1510T>G	c.(1510-1512)Ttc>Gtc	p.F504V	MRE11A_ENST00000407439.3_Missense_Mutation_p.F507V|MRE11A_ENST00000323977.3_Missense_Mutation_p.F504V|MRE11A_ENST00000393241.4_Missense_Mutation_p.F504V	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	504					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GTTTCTCTGAAACGACGTACC	0.318000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				7	7					0	0	0.006214	0	0
KCNN2	3781	broad.mit.edu	37	5	113831826	113831826	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:113831826A>T	ENST00000512097.3	+	9	2705	c.1687A>T	c.(1687-1689)Agg>Tgg	p.R563W	KCNN2_ENST00000503706.1_Missense_Mutation_p.R215W|KCNN2_ENST00000264773.3_Missense_Mutation_p.R563W|RP11-492A10.1_ENST00000514115.1_RNA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	563	Poly-Arg.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GTCCTCGTCCAGGAGGCGGCG	0.502000													12	31					0	0	0.012319	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291192	141291192	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:141291192G>T	ENST00000247452.3	-	3	929	c.582C>A	c.(580-582)ggC>ggA	p.G194G		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	194	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGGCAAGGCCAAAAAGAA	0.488000										HNSCC(46;0.14)			186	314					1.18408e-101	2.26497e-101	0.014410	1	0
PCDH17	27253	broad.mit.edu	37	13	58209103	58209103	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:58209103C>A	ENST00000377918.3	+	1	2449	c.2423C>A	c.(2422-2424)tCg>tAg	p.S808*		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	808					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCCTCAGCTCGCCCCGGTCG	0.637000													2	3					5.9392e-07	7.5247e-07	0.001168	1	0
B2M	567	broad.mit.edu	37	15	45007672	45007672	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:45007672C>G	ENST00000558401.1	+	2	189	c.119C>G	c.(118-120)tCa>tGa	p.S40*	B2M_ENST00000559220.1_Intron|B2M_ENST00000544417.1_Nonsense_Mutation_p.S40*|B2M_ENST00000559916.1_Nonsense_Mutation_p.S40*	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	40	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		AATGGAAAGTCAAATTTCCTG	0.403000													7	89					0	0	0.003080	0	0
SEC23IP	11196	broad.mit.edu	37	10	121689157	121689157	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:121689157G>C	ENST00000369075.3	+	14	2424	c.2352G>C	c.(2350-2352)gaG>gaC	p.E784D	SEC23IP_ENST00000475542.1_3'UTR|SEC23IP_ENST00000543134.1_Missense_Mutation_p.E573D	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	784	DDHD.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TTGAACCAGAGATATTCTTTG	0.368000													21	28					0	0	0.014323	0	0
MYCL	4610	broad.mit.edu	37	1	40363231	40363231	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:40363231G>C	ENST00000397332.2	-	3	1122	c.998C>G	c.(997-999)gCg>gGg	p.A333G	MYCL_ENST00000372816.2_Missense_Mutation_p.A303G	NM_001033081.2|NM_001033082.2	NP_001028253.1|NP_001028254.2			v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog																		GTCCCTCAGCGCCAAGAATCG	0.572000													6	13					0	0	0.010729	0	0
UNC5D	137970	broad.mit.edu	37	8	35583890	35583890	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:35583890G>T	ENST00000287272.2	+	9	1337	c.1317G>T	c.(1315-1317)agG>agT	p.R439S	UNC5D_ENST00000453357.2_Missense_Mutation_p.R503S|UNC5D_ENST00000420357.1_Missense_Mutation_p.R441S|UNC5D_ENST00000416672.1_Missense_Mutation_p.R513S|UNC5D_ENST00000404895.2_Missense_Mutation_p.R508S|UNC5D_ENST00000449677.1_Missense_Mutation_p.R84S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	508					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ATCATTCCAGGACTTTTCCCC	0.463000													11	60					2.27111e-07	2.9281e-07	0.013537	1	0
WDR65	149465	broad.mit.edu	37	1	43649515	43649515	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:43649515C>A	ENST00000372492.4	+	4	1052	c.728C>A	c.(727-729)tCa>tAa	p.S243*	WDR65_ENST00000528956.1_Nonsense_Mutation_p.S243*	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	243										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCAATGGCTCAAAGAGCCTG	0.483000													36	144					7.53189e-24	1.31733e-23	0.007835	1	0
DCLRE1A	9937	broad.mit.edu	37	10	115612691	115612691	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:115612691C>A	ENST00000361384.2	-	1	1168	c.251G>T	c.(250-252)tGt>tTt	p.C84F	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.C84F	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	84	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		ACCATCTCCACAACTTGAATT	0.453000								Other identified genes with known or suspected DNA repair function					37	52					2.40579e-17	3.94083e-17	0.006230	1	0
CDAN1	146059	broad.mit.edu	37	15	43019893	43019893	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:43019893C>A	ENST00000356231.3	-	23	3045	c.3022G>T	c.(3022-3024)Ggg>Tgg	p.G1008W		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	1008						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTCCGCTCCCCCCGGGCAGCA	0.627000													6	5					0.00307968	0.00327356	0.003080	1	0
TRAT1	50852	broad.mit.edu	37	3	108572570	108572570	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:108572570G>A	ENST00000295756.6	+	6	637	c.407G>A	c.(406-408)gGa>gAa	p.G136E	TRAT1_ENST00000426646.1_Missense_Mutation_p.G99E	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	136					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						GACAAGGATGGAGATGAGCAA	0.453000													10	38					0	0	0.013537	0	0
MMP16	4325	broad.mit.edu	37	8	89180006	89180006	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:89180006C>A	ENST00000286614.6	-	4	882	c.601G>T	c.(601-603)Gga>Tga	p.G201*	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	201					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						CCTCCCTCTCCATCAAAGGGA	0.443000													13	26					2.32078e-09	3.21396e-09	0.003163	1	0
RHOJ	57381	broad.mit.edu	37	14	63749849	63749849	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:63749849G>T	ENST00000316754.3	+	4	875	c.413G>T	c.(412-414)cGt>cTt	p.R138L	RHOJ_ENST00000555125.1_Missense_Mutation_p.R138L	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	138					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		ATTGATCTCCGTGATGACCCA	0.423000													30	48					5.43694e-19	9.09263e-19	0.005524	1	0
ADCY2	108	broad.mit.edu	37	5	7626402	7626402	+	Silent	SNP	C	C	A	rs6865872		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:7626402C>A	ENST00000338316.4	+	4	782	c.693C>A	c.(691-693)atC>atA	p.I231I		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	231					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AGTCGCGGATCAAGTTGGAAT	0.398000													10	34					9.31168e-06	1.12303e-05	0.016723	1	0
LILRA1	11024	broad.mit.edu	37	19	55106169	55106169	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:55106169C>A	ENST00000453777.1	+	4	280	c.110C>A	c.(109-111)tCt>tAt	p.S37Y	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.S37Y|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	37	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GAGCCAGGCTCTGTGATCACC	0.542000													13	23					8.00594e-06	9.68211e-06	0.007413	1	0
NEDD1	121441	broad.mit.edu	37	12	97334303	97334303	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:97334303C>A	ENST00000266742.4	+	10	1573	c.1234C>A	c.(1234-1236)Cct>Act	p.P412T	NEDD1_ENST00000457368.2_Missense_Mutation_p.P323T|NEDD1_ENST00000557644.1_Missense_Mutation_p.P419T|NEDD1_ENST00000429527.2_Missense_Mutation_p.P412T|NEDD1_ENST00000411739.2_Missense_Mutation_p.P323T	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	412					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						CATGTTCTCACCTATCAGAGA	0.373000													15	33					6.94344e-10	9.80119e-10	0.006122	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28337809	28337809	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:28337809A>C	ENST00000284987.5	-	1	1023	c.902T>G	c.(901-903)cTg>cGg	p.L301R		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	301	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						ATGGCTGTACAGCCTATTGGC	0.612000													12	29					0	0	0.003163	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109130	106109130	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:106109130C>G	ENST00000357242.5	+	16	2703	c.2529C>G	c.(2527-2529)ttC>ttG	p.F843L	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.F837L	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	843						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCCAGCAGTTCAGAGCGTTGT	0.418000													23	312					0	0	0.004656	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5655032	5655032	+	Splice_Site	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:5655032A>T	ENST00000354852.5	+	9	1658		c.e9-1		TRIM34_ENST00000514226.1_Splice_Site|HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000429814.2_Splice_Site|TRIM6-TRIM34_ENST00000457787.2_Splice_Site	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN								intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CCCTTCTCATAGGAGAAACTC	0.438000													11	21					0	0	0.016723	0	0
FYB	2533	broad.mit.edu	37	5	39203010	39203010	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:39203010C>A	ENST00000351578.6	-	2	243	c.53G>T	c.(52-54)aGc>aTc	p.S18I	FYB_ENST00000515010.1_Missense_Mutation_p.S18I|FYB_ENST00000505428.1_Missense_Mutation_p.S18I|FYB_ENST00000512982.1_Missense_Mutation_p.S18I|FYB_ENST00000540520.1_Missense_Mutation_p.S28I	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	18					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GAAGGGTCGGCTATTGACTGA	0.483000													38	73					3.68427e-32	6.71118e-32	0.010771	1	0
EPG5	57724	broad.mit.edu	37	18	43490647	43490647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:43490647C>A	ENST00000282041.5	-	23	4078	c.4044G>T	c.(4042-4044)ttG>ttT	p.L1348F	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1348					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TTTCTTTCAACAAATTGATAT	0.453000											OREG0024952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	38					1.39806e-14	2.19981e-14	0.008361	1	0
SLC12A1	6557	broad.mit.edu	37	15	48513161	48513161	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:48513161G>T	ENST00000396577.3	+	4	811	c.596G>T	c.(595-597)cGc>cTc	p.R199L	SLC12A1_ENST00000558405.1_Missense_Mutation_p.R199L|SLC12A1_ENST00000380993.3_Missense_Mutation_p.R199L|SLC12A1_ENST00000561031.1_Missense_Mutation_p.R199L|SLC12A1_ENST00000330289.6_Missense_Mutation_p.R199L	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	199					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CTCTTCATTCGCCTCTCCTGG	0.408000													33	60					4.34311e-12	6.48511e-12	0.015359	1	0
ZP4	57829	broad.mit.edu	37	1	238053214	238053214	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:238053214T>A	ENST00000366570.4	-	3	511	c.353A>T	c.(352-354)aAg>aTg	p.K118M	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	118					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGTAACCACCTTGTGTTCAGC	0.572000													49	145					0	0	0.014410	0	0
SLC15A1	6564	broad.mit.edu	37	13	99364189	99364189	+	Silent	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:99364189G>T	ENST00000376503.5	-	11	874	c.819C>A	c.(817-819)ctC>ctA	p.L273L		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	273					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TTTGGGAGATGAGCCGCTCCT	0.507000													13	18					2.23348e-06	2.77369e-06	0.004007	1	0
SPANXN3	139067	broad.mit.edu	37	X	142596910	142596910	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:142596910C>G	ENST00000370503.2	-	2	243	c.160G>C	c.(160-162)Gtg>Ctg	p.V54L	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	54										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTAATACACAAATATTATT	0.393000													193	516					0	0	0.014410	0	0
PCLO	27445	broad.mit.edu	37	7	82387925	82387925	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:82387925T>G	ENST00000333891.8	-	25	15732	c.15395A>C	c.(15394-15396)cAc>cCc	p.H5132P		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	5055					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CAAAAGTTTGTGCCAGTTGAC	0.393000													32	131					0	0	0.007835	0	0
OR52A4P	390053	broad.mit.edu	37	11	5142800	5142800	+	RNA	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:5142800C>A	ENST00000498233.1	-	0	598																				breast(1)|endometrium(2)|kidney(1)|lung(12)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTGTAATAGGCAGGGCCATTC	0.398000													50	132					3.07002e-29	5.50097e-29	0.014410	1	0
PDE10A	10846	broad.mit.edu	37	6	165863795	165863795	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:165863795T>C	ENST00000366882.1	-	5	405	c.251A>G	c.(250-252)cAa>cGa	p.Q84R	PDE10A_ENST00000539869.2_Missense_Mutation_p.Q94R|PDE10A_ENST00000354448.4_Missense_Mutation_p.Q84R			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	84					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTCCAACCGTTGTTCTATATA	0.333000													13	40					0	0	0.004007	0	0
KIAA1551	55196	broad.mit.edu	37	12	32134159	32134159	+	Silent	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:32134159A>G	ENST00000312561.4	+	4	684	c.270A>G	c.(268-270)gtA>gtG	p.V90V	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ACACTTCAGTAGAAAGAATAA	0.378000													10	22					0	0	0.016723	0	0
TEX14	56155	broad.mit.edu	37	17	56636858	56636858	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:56636858G>T	ENST00000389934.3	-	31	4460	c.4343C>A	c.(4342-4344)cCa>cAa	p.P1448Q	TEX14_ENST00000240361.8_Missense_Mutation_p.P1454Q|TEX14_ENST00000584699.1_5'UTR|TEX14_ENST00000349033.5_Missense_Mutation_p.P1408Q	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1454						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTTCTTTCTGGTGTAATGCT	0.358000													58	116					5.80444e-35	1.07744e-34	0.014410	1	0
ECT2L	345930	broad.mit.edu	37	6	139197684	139197684	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:139197684C>G	ENST00000423192.1	+	13	1815	c.1654C>G	c.(1654-1656)Ctg>Gtg	p.L552V	ECT2L_ENST00000541398.1_Missense_Mutation_p.L483V|ECT2L_ENST00000367682.2_Missense_Mutation_p.L552V			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	552					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						TTTTGAAGCACTGATTAATCT	0.333000			"""N, Splice, Mis"""		ETP ALL								5	18					0	0	0.001168	0	0
OSBPL8	114882	broad.mit.edu	37	12	76763016	76763016	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:76763016T>C	ENST00000261183.3	-	21	2785	c.2306A>G	c.(2305-2307)aAa>aGa	p.K769R	OSBPL8_ENST00000393249.2_Missense_Mutation_p.K727R|OSBPL8_ENST00000393250.4_Missense_Mutation_p.K727R	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	769					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						ATGTTTCACTTTGGTCTGAAT	0.308000													9	37					0	0	0.010729	0	0
PABPC3	5042	broad.mit.edu	37	13	25670841	25670841	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:25670841T>A	ENST00000281589.3	+	1	542	c.505T>A	c.(505-507)Ttt>Att	p.F169I		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	169	RRM 2.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCGCAAAGTATTTGTTGGACA	0.393000													13	13					0	0	0.003163	0	0
CSRNP3	80034	broad.mit.edu	37	2	166535905	166535905	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:166535905T>C	ENST00000314499.7	+	7	1776	c.1400T>C	c.(1399-1401)cTg>cCg	p.L467P	CSRNP3_ENST00000342316.4_Missense_Mutation_p.L467P|CSRNP3_ENST00000409420.1_Missense_Mutation_p.L499P	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	467					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						ACCCTTTCGCTGGTGCCTTAC	0.488000													28	108					0	0	0.009535	0	0
SLC41A1	254428	broad.mit.edu	37	1	205764004	205764004	+	Silent	SNP	C	C	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:205764004C>T	ENST00000367137.3	-	10	2364	c.1350G>A	c.(1348-1350)ctG>ctA	p.L450L	SLC41A1_ENST00000468057.1_5'UTR	NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	450						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GTACCTGGAGCAGTGCAGCTG	0.572000													8	17					0	0	0.013537	0	0
MMRN1	22915	broad.mit.edu	37	4	90816172	90816172	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:90816172G>T	ENST00000394980.1	+	2	369	c.50G>T	c.(49-51)gGc>gTc	p.G17V	MMRN1_ENST00000264790.2_Missense_Mutation_p.G17V|MMRN1_ENST00000394981.1_Missense_Mutation_p.G17V			Q13201	MMRN1_HUMAN	multimerin 1	17					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGGAGTGGGGGCATTGGGCTT	0.418000													4	81					0.00024832	0.000280238	0.009096	1	0
GRID2	2895	broad.mit.edu	37	4	94690559	94690559	+	Silent	SNP	G	G	C	rs151216204	byFrequency	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:94690559G>C	ENST00000282020.4	+	15	2817	c.2559G>C	c.(2557-2559)acG>acC	p.T853T	GRID2_ENST00000510992.1_Silent_p.T758T	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	853					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGCTGGAGACGTGGTGGAACA	0.493000													22	55					0	0	0.016522	0	0
DNAJC5B	85479	broad.mit.edu	37	8	67012238	67012238	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:67012238G>C	ENST00000276570.5	+	6	859	c.572G>C	c.(571-573)gGa>gCa	p.G191A	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	191					protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ATCAAAGAAGGATCTCGAAGT	0.428000													11	35					0	0	0.020292	0	0
AKAP9	10142	broad.mit.edu	37	7	91712887	91712887	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:91712887G>T	ENST00000359028.2	+	34	8825	c.8600G>T	c.(8599-8601)aGg>aTg	p.R2867M	AKAP9_ENST00000358100.2_Missense_Mutation_p.R2867M|AKAP9_ENST00000356239.3_Missense_Mutation_p.R2855M			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2867					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACCTTAAAGAGGGAACACTAT	0.368000			T	BRAF	papillary thyroid								8	21					5.18039e-06	6.3348e-06	0.003080	1	0
VNN2	8875	broad.mit.edu	37	6	133072510	133072510	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:133072510G>A	ENST00000326499.6	-	5	1098	c.974C>T	c.(973-975)aCc>aTc	p.T325I	VNN2_ENST00000525289.1_Intron|VNN2_ENST00000525270.1_Missense_Mutation_p.T272I	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	325	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		TTTGATGGTGGTGGCGTAGGC	0.438000													37	73					0	0	0.014410	0	0
CHIA	27159	broad.mit.edu	37	1	111861779	111861779	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:111861779G>A	ENST00000369740.1	+	10	1056	c.953G>A	c.(952-954)tGg>tAg	p.W318*	CHIA_ENST00000343320.6_Nonsense_Mutation_p.W318*|CHIA_ENST00000353665.6_Nonsense_Mutation_p.W157*|CHIA_ENST00000430615.1_Nonsense_Mutation_p.W210*|CHIA_ENST00000483391.1_Nonsense_Mutation_p.W157*|CHIA_ENST00000451398.2_Nonsense_Mutation_p.W157*|RP5-1125M8.2_ENST00000426321.1_RNA	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	318					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		ACTCAGGGATGGGATGCCCCT	0.408000													23	49					0	0	0.007291	0	0
SV2C	22987	broad.mit.edu	37	5	75427754	75427754	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:75427754C>A	ENST00000502798.2	+	2	621	c.179C>A	c.(178-180)cCg>cAg	p.P60Q	SV2C_ENST00000322285.7_Missense_Mutation_p.P60Q	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	60					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity	p.P60Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GACTACTACCCGGCTGGAGAA	0.493000													23	57					2.65835e-16	4.26696e-16	0.007291	1	0
FUT9	10690	broad.mit.edu	37	6	96651918	96651918	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:96651918G>A	ENST00000302103.5	+	3	1213	c.887G>A	c.(886-888)aGt>aAt	p.S296N		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	296					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AACTCTCCCAGTGAGCTAGCA	0.383000													13	25					0	0	0.020292	0	0
CACNA1E	777	broad.mit.edu	37	1	181549889	181549889	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:181549889G>T	ENST00000526775.1	+	6	1093	c.928G>T	c.(928-930)Ggg>Tgg	p.G310W	CACNA1E_ENST00000357570.5_Missense_Mutation_p.G261W|CACNA1E_ENST00000367570.1_Missense_Mutation_p.G310W|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G310W|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G261W|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G310W	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	310					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.G310W(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CACCATGGAAGGGTGGACCAC	0.527000													17	71					4.96729e-08	6.55832e-08	0.008871	1	0
LAMB4	22798	broad.mit.edu	37	7	107688431	107688431	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:107688431C>A	ENST00000388781.3	-	28	4331	c.4248G>T	c.(4246-4248)acG>acT	p.T1416T	LAMB4_ENST00000388780.3_Silent_p.T1416T|LAMB4_ENST00000205386.4_Silent_p.T1416T	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1416	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GGAGGGCATTCGTTGAGAGGG	0.527000													7	21					5.18039e-06	6.3348e-06	0.003080	1	0
ADAM20	8748	broad.mit.edu	37	14	70991419	70991419	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:70991419A>T	ENST00000256389.3	-	2	450	c.206T>A	c.(205-207)tTt>tAt	p.F69Y	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	19					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		AAACATCCCAAACCAGAGCAG	0.517000													35	86					0	0	0.007835	0	0
LRP1B	53353	broad.mit.edu	37	2	141773438	141773438	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:141773438C>A	ENST00000389484.3	-	13	2988	c.2017G>T	c.(2017-2019)Gtg>Ttg	p.V673L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	673					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.V673L(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCCTTCCCACGCTGTCATCT	0.413000										TSP Lung(27;0.18)			8	35					0.000274275	0.00030716	0.004482	1	0
ACSM4	341392	broad.mit.edu	37	12	7475905	7475905	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:7475905G>T	ENST00000399422.4	+	8	1249	c.1201G>T	c.(1201-1203)Gtc>Ttc	p.V401F		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	401					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GCCCTATGATGTCCAGGTAGG	0.398000													8	21					4.68919e-08	6.20982e-08	0.008291	1	0
HDAC9	9734	broad.mit.edu	37	7	19015514	19015514	+	Silent	SNP	C	C	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:19015514C>A	ENST00000406451.3	+	25	3249	c.3099C>A	c.(3097-3099)acC>acA	p.T1033T	HDAC9_ENST00000401921.1_Silent_p.T992T|HDAC9_ENST00000441542.2_Silent_p.T1036T	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	0					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.V1037fs*25(1)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AGACAGAGACCGTTTCTGCCC	0.537000													19	33					7.07596e-05	8.20699e-05	0.006122	1	0
NUP205	23165	broad.mit.edu	37	7	135309964	135309964	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:135309964A>G	ENST00000285968.6	+	32	4558	c.4532A>G	c.(4531-4533)cAg>cGg	p.Q1511R		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1511					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AAACAGCAGCAGTGGCTTTTG	0.443000													10	27					0	0	0.012319	0	0
TBX21	30009	broad.mit.edu	37	17	45821856	45821856	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:45821856G>T	ENST00000177694.1	+	5	1147	c.936G>T	c.(934-936)caG>caT	p.Q312H		NM_013351.1	NP_037483.1	Q9UL17	TBX21_HUMAN	T-box 21	312					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|endometrium(1)|large_intestine(3)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	22						AGATTACTCAGCTGAAAATTG	0.502000													19	104					1.87028e-06	2.32923e-06	0.012319	1	0
PADI6	353238	broad.mit.edu	37	1	17721722	17721723	+	RNA	DEL	GA	GA	-	rs58784721		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:17721722_17721723delGA	ENST00000434762.2	+	0	1545							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	tttgttttttgagagtcttgct	0.485													2	4	---	---	---	---					
SSBP3	23648	broad.mit.edu	37	1	54747155	54747156	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:54747155_54747156insG	ENST00000371320.3	-	5	731_732	c.321_322insC	c.(319-324)ccacgafs	p.R108fs	SSBP3_ENST00000417664.2_5'UTR|SSBP3_ENST00000371319.3_Frame_Shift_Ins_p.R108fs|SSBP3_ENST00000357475.4_Frame_Shift_Ins_p.R108fs|SSBP3_ENST00000326956.7_5'UTR	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	108	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						ATCCCATCGTTGGGGGGAATGT	0.619													2	4	---	---	---	---					
RP11-776H12.1	0	broad.mit.edu	37	1	61069076	61069076	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:61069076delG	ENST00000439156.2	-	0	336																											ctctcttagtggtacataaac	0.338													2	4	---	---	---	---					
RP11-417J8.2	0	broad.mit.edu	37	1	142572757	142572758	+	RNA	INS	-	-	C	rs78821059	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:142572757_142572758insC	ENST00000415979.2	-	0	215																											ACTATTCTTTTCCGttttttaa	0.361													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142662521	142662522	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:142662521_142662522insT	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							CCTGCTGCTCGTTTCGGCTATG	0.550													4	5	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143422088	143422088	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:143422088delC	ENST00000423249.1	-	0	59																											tgtgttcatactggcaacaag	0.458													9	9	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	144024729	144024742	+	RNA	DEL	TTTTTTTGTTGTTG	TTTTTTTGTTGTTG	-	rs67150523	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:144024729_144024742delTTTTTTTGTTGTTG	ENST00000467933.1	+	0	1108																											ttttttgttttttttttgttgttgttgttgttgt	0.364													11	5	---	---	---	---					
ILDR2	387597	broad.mit.edu	37	1	166869639	166869639	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:166869639delC	ENST00000414590.1	-	0	171																											AAGCATCCTACCCCCACAAAT	0.398													2	4	---	---	---	---					
RP1-15D23.2	0	broad.mit.edu	37	1	172885078	172885078	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:172885078delT	ENST00000432694.1	+	0	223																											CCACCCTTACTATGAGATAAA	0.403													2	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213905702	213905703	+	RNA	DEL	GC	GC	-	rs1771902	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:213905702_213905703delGC	ENST00000456240.1	+	0	143																											gtgtgcgtgtgcgtgtgtgtgt	0.361													2	4	---	---	---	---					
LYPLAL1-AS1	643723	broad.mit.edu	37	1	219262304	219262305	+	RNA	DEL	AG	AG	-	rs35604139		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:219262304_219262305delAG	ENST00000441331.1	-	0	665																											gtgctgggctagaaggcagtag	0.550													3	3	---	---	---	---					
ZP4	57829	broad.mit.edu	37	1	238053464	238053465	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr1:238053464_238053465insG	ENST00000366570.4	-	2	345_346	c.187_188insC	c.(187-189)gctfs	p.A63fs	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	63					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CTCGTGCAGCAGCCCTTGGTTG	0.559													12	52	---	---	---	---					
LOC101929452	101929452	broad.mit.edu	37	2	7209247	7209247	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:7209247delG	ENST00000415520.1	-	0	342																											gatttCACATGGGGCTTGTCC	0.512													2	4	---	---	---	---					
LOC100506274	100506274	broad.mit.edu	37	2	7588345	7588346	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:7588345_7588346insC	ENST00000435062.2	+	0	1882																											ttcctgatccgcccccctcagc	0.510													2	4	---	---	---	---					
LOC101929551	101929551	broad.mit.edu	37	2	8038203	8038204	+	RNA	INS	-	-	GAAG	rs5829130		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:8038203_8038204insGAAG	ENST00000416534.1	-	0	50																											aaaaagagagagaaagaatgaa	0.431													3	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14499054	14499055	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:14499054_14499055insT	ENST00000418420.1	-	0	116					NR_103814.1																						atgccaaaaaactgtgagtTGg	0.495													2	4	---	---	---	---					
AC068286.1	0	broad.mit.edu	37	2	15035864	15035864	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:15035864delA	ENST00000416173.1	-	0	92																											actccgtctcaaaaaaaaaaa	0.493													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22174521	22174522	+	RNA	INS	-	-	AGAA	rs79348110	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:22174521_22174522insAGAA	ENST00000450551.1	-	0	296				AC068490.1_ENST00000430520.1_lincRNA																							gtgatgaagagagaaagaaagg	0.381													3	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	59185581	59185582	+	RNA	DEL	AC	AC	-	rs113407515		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:59185581_59185582delAC	ENST00000452840.1	+	0	815																											ACTTTGTCAAacacacacacac	0.470													3	5	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60160308	60160309	+	RNA	DEL	CA	CA	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:60160308_60160309delCA	ENST00000606382.1	-	0	110																											cacacatatgcacacacacaca	0.391													3	5	---	---	---	---					
AC008074.3	0	broad.mit.edu	37	2	64676255	64676255	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:64676255delA	ENST00000441630.1	-	0	106																											caatgcacacaaatctctCAA	0.413													4	2	---	---	---	---					
DGUOK-AS1	100874048	broad.mit.edu	37	2	74195703	74195704	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:74195703_74195704insC	ENST00000453103.1	-	0	307				DGUOK-AS1_ENST00000413452.1_RNA|DGUOK-AS1_ENST00000439192.1_RNA																							tggttgccctacccccccacac	0.569													3	5	---	---	---	---					
RNF103	7844	broad.mit.edu	37	2	86831528	86831529	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:86831528_86831529insA	ENST00000237455.4	-	4	2463_2464	c.1495_1496insT	c.(1495-1497)gctfs	p.A499fs	AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000424788.1_RNA|AC015971.2_ENST00000597638.1_RNA|AC015971.2_ENST00000426549.1_RNA|CHMP3_ENST00000439940.2_Intron|RNF103-CHMP3_ENST00000604011.1_Intron	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	499					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						AGGGTGAAGCCAAAGGTCAGGG	0.446													26	107	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91879666	91879667	+	RNA	INS	-	-	AC			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:91879666_91879667insAC	ENST00000436174.1	-	0	1044																											AAAatatatatacacacacaca	0.307													2	4	---	---	---	---					
AC074363.1	0	broad.mit.edu	37	2	168314300	168314300	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:168314300delA	ENST00000442316.1	+	0	164																											gtgaaccagcagcaccggcag	0.463													2	4	---	---	---	---					
AC019330.1	0	broad.mit.edu	37	2	199583342	199583343	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:199583342_199583343insG	ENST00000440609.1	-	0	98																											ATGAGATTGAAGGtttttttta	0.366													2	4	---	---	---	---					
LANCL1-AS1	102724820	broad.mit.edu	37	2	211225265	211225266	+	RNA	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr2:211225265_211225266insA	ENST00000433296.1	+	0	76				AC007970.1_ENST00000420418.1_RNA																							cctgtgatgggaaccatctgtg	0.530													2	4	---	---	---	---					
SATB1	6304	broad.mit.edu	37	3	18427992	18427993	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:18427992_18427993delTT	ENST00000338745.6	-	8	3051_3052	c.1317_1318delAA	c.(1315-1320)gagafs	p.ER439fs	SATB1_ENST00000417717.2_Frame_Shift_Del_p.ER439fs|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Frame_Shift_Del_p.ER439fs	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	439					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						ATTCGGTCTCTTTCAGCTTCCG	0.550													30	37	---	---	---	---					
RP11-708J19.1	0	broad.mit.edu	37	3	47420860	47420861	+	RNA	INS	-	-	T	rs77387132		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:47420860_47420861insT	ENST00000568593.1	-	0	1628_1629																											tttttcttttcttttttttttt	0.475													2	4	---	---	---	---					
STAB1	23166	broad.mit.edu	37	3	52536029	52536030	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:52536029_52536030insG	ENST00000321725.6	+	4	415_416	c.339_340insG	c.(337-342)ccggggfs	p.PG113fs		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	113	EGF-like 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CAGAATGCCCTGGGGGCGCTGA	0.649													2	4	---	---	---	---					
RP11-654C22.2	0	broad.mit.edu	37	3	72583644	72583644	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:72583644delA	ENST00000478745.1	-	0	582																											CTGAGACAGGAAATAAAGATT	0.438													2	4	---	---	---	---					
LOC101929717	101929717	broad.mit.edu	37	3	112864257	112864257	+	RNA	DEL	G	G	-	rs7619785	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:112864257delG	ENST00000490139.1	-	0	516				RP11-572M11.4_ENST00000496389.1_RNA																							GAGATATCTCGTTTTTTTTTA	0.323													3	3	---	---	---	---					
SLC15A2	6565	broad.mit.edu	37	3	121634527	121634527	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:121634527delG	ENST00000489711.1	+	7	1072	c.684delG	c.(682-684)atfs	p.M228fs	SLC15A2_ENST00000295605.2_Frame_Shift_Del_p.M197fs	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	228					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GACTGCTCATGGTAATTGCAC	0.413													12	75	---	---	---	---					
NPHP3-AS1	348808	broad.mit.edu	37	3	132507528	132507529	+	RNA	INS	-	-	AAG	rs144148966	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:132507528_132507529insAAG	ENST00000504440.1	+	0	249					NR_002811.1																						AGAGGCTTTCAAAGGTTTTTCA	0.391													4	3	---	---	---	---					
PAQR9-AS1	101927832	broad.mit.edu	37	3	142686515	142686515	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:142686515delT	ENST00000595248.1	+	0	140				RP11-372E1.6_ENST00000598787.1_RNA|RP11-372E1.6_ENST00000598139.1_RNA|RP11-372E1.6_ENST00000497652.1_RNA|RP11-372E1.6_ENST00000595774.1_RNA																							GAAAGCCAGGTAGAGGGCTGG	0.443													2	4	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146829216	146829216	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:146829216delG	ENST00000473299.1	-	0	229																											cagatgcatagtttgcaaaaa	0.323													2	4	---	---	---	---					
RP11-454C18.1	0	broad.mit.edu	37	3	151360926	151360926	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:151360926delG	ENST00000492731.1	+	0	268																											agccaggcatggtggttggcg	0.483													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153111138	153111141	+	RNA	DEL	TTTC	TTTC	-	rs145607501		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:153111138_153111141delTTTC	ENST00000493214.2	-	0	381																											gtatttgaagtttctttctttctt	0.328													4	4	---	---	---	---					
DHX36	170506	broad.mit.edu	37	3	154027551	154027551	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:154027551delC	ENST00000496811.1	-	5	784	c.704delG	c.(703-705)gcfs	p.G235fs	DHX36_ENST00000308361.6_Frame_Shift_Del_p.G235fs|DHX36_ENST00000329463.5_Frame_Shift_Del_p.G235fs|DHX36_ENST00000544526.1_Frame_Shift_Del_p.G235fs	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	235	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGTGGTTTTGCCACAACCAGT	0.338													8	10	---	---	---	---					
LINC00880	339894	broad.mit.edu	37	3	156805948	156805949	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:156805948_156805949insT	ENST00000471357.1	-	0	409				RP11-6F2.5_ENST00000469196.1_lincRNA	NR_034007.1																						GAAAATTCCTATTTAAAGAAGC	0.416													2	4	---	---	---	---					
RP11-550I24.2	0	broad.mit.edu	37	3	156974740	156974740	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:156974740delC	ENST00000488040.1	+	0	253				RP11-550I24.2_ENST00000475102.1_RNA|RP11-550I24.2_ENST00000487238.1_RNA																							CCAGTAAATGCCCCTTGACAT	0.388													7	5	---	---	---	---					
TNIK	23043	broad.mit.edu	37	3	170843705	170843705	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:170843705delG	ENST00000436636.2	-	17	2353	c.2009delC	c.(2008-2010)cafs	p.P670fs	TNIK_ENST00000357327.5_Frame_Shift_Del_p.P641fs|TNIK_ENST00000488470.1_Frame_Shift_Del_p.P615fs|TNIK_ENST00000538048.1_Frame_Shift_Del_p.P615fs|TNIK_ENST00000369326.5_Frame_Shift_Del_p.P641fs|TNIK_ENST00000284483.8_Frame_Shift_Del_p.P670fs|TNIK_ENST00000341852.6_Frame_Shift_Del_p.P586fs|TNIK_ENST00000475336.1_Frame_Shift_Del_p.P586fs|TNIK_ENST00000460047.1_Frame_Shift_Del_p.P615fs|TNIK_ENST00000470834.1_Frame_Shift_Del_p.P641fs	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	670	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TATTACCTTTGGTGGAATGTC	0.433													18	63	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177357631	177357632	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr3:177357631_177357632insT	ENST00000442937.1	+	0	428					NR_047568.1																						cttttttctggttttttgattc	0.347													2	4	---	---	---	---					
RP11-3J1.1	0	broad.mit.edu	37	4	19434595	19434596	+	RNA	INS	-	-	TC	rs78165579	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:19434595_19434596insTC	ENST00000505347.1	-	0	349																											ttttttttttttttttgagaca	0.436													3	3	---	---	---	---					
RP11-380P13.1	0	broad.mit.edu	37	4	23675320	23675320	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:23675320delC	ENST00000514290.1	+	0	117																											tttgttcaatcctttctcttt	0.323													2	4	---	---	---	---					
PPARGC1A	10891	broad.mit.edu	37	4	23803407	23803408	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:23803407_23803408insA	ENST00000264867.2	-	12	2357_2358	c.2238_2239insT	c.(2236-2241)ttagctfs	p.LA746fs	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	746	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				AAGTACAGCTCAAAGTCAGTTT	0.411													20	38	---	---	---	---					
AC024132.1	0	broad.mit.edu	37	4	27217410	27217411	+	RNA	INS	-	-	T	rs147635513		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:27217410_27217411insT	ENST00000382007.1	-	0	263																											TGTTTGTTTTCTTTTTTTTTTT	0.416													3	3	---	---	---	---					
RP11-704M14.1	0	broad.mit.edu	37	4	70051455	70051456	+	RNA	DEL	GT	GT	-	rs7689117	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:70051455_70051456delGT	ENST00000504301.1	+	0	273																											cctggattcggtttgtcagtat	0.386													2	4	---	---	---	---					
MUC7	4589	broad.mit.edu	37	4	71346782	71346783	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:71346782_71346783insA	ENST00000413702.1	+	4	609_610	c.321_322insA	c.(319-324)gccaacfs	p.N108fs	MUC7_ENST00000456088.1_Frame_Shift_Ins_p.N108fs|MUC7_ENST00000304887.5_Frame_Shift_Ins_p.N108fs|MUC7_ENST00000514512.1_3'UTR	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	108	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			CCTTAGTGGCTACAACCCAAAT	0.450													26	99	---	---	---	---					
RP11-542G1.1	0	broad.mit.edu	37	4	76275099	76275100	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:76275099_76275100insG	ENST00000505930.1	-	0	41				RP11-542G1.2_ENST00000509215.1_lincRNA																							aattgaatcatgggggcagttt	0.431													2	4	---	---	---	---					
RP11-567N4.2	0	broad.mit.edu	37	4	76307007	76307008	+	RNA	INS	-	-	A	rs144905451	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:76307007_76307008insA	ENST00000510744.1	-	0	332																											ggcagagacacaaaaaaaaaag	0.361													2	4	---	---	---	---					
PCAT4	118425	broad.mit.edu	37	4	80774770	80774771	+	RNA	DEL	AA	AA	-	rs147684879		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:80774770_80774771delAA	ENST00000504263.1	+	0	133					NR_026555.1																						ctggagtcagaaaaaaaaaaaa	0.347													4	2	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82642057	82642058	+	RNA	INS	-	-	G	rs112753880		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:82642057_82642058insG	ENST00000510780.1	-	0	390																											tatgaaaaaaattcatcatcac	0.332													2	4	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82671208	82671209	+	RNA	DEL	TT	TT	-	rs75083688		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:82671208_82671209delTT	ENST00000510780.1	-	0	390																											agttccactcttttacttccaa	0.446													3	4	---	---	---	---					
RAP1GDS1	5910	broad.mit.edu	37	4	99313231	99313231	+	Splice_Site	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:99313231delG	ENST00000408927.3	+	6	750	c.637_splice	c.e6+1	p.E213_splice	RAP1GDS1_ENST00000380158.4_Splice_Site_p.E165_splice|RAP1GDS1_ENST00000264572.7_Intron|RAP1GDS1_ENST00000453712.2_Splice_Site_p.E214_splice|RAP1GDS1_ENST00000339360.5_Splice_Site_p.E214_splice|RAP1GDS1_ENST00000408900.3_Splice_Site_p.E164_splice	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	213							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		AGCAGAACTTGGTAAGTCTTA	0.333			T	NUP98	T-ALL								9	23	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105525174	105525174	+	RNA	DEL	T	T	-	rs58379600		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:105525174delT	ENST00000500179.1	+	0	96																											tggaatgttctttgtgtgtct	0.413													3	4	---	---	---	---					
LOC101929577	101929577	broad.mit.edu	37	4	106940574	106940575	+	RNA	INS	-	-	C	rs140372022	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:106940574_106940575insC	ENST00000513220.1	-	0	2670																											ACTTGCACGTTCCTTAGGTATG	0.436													5	8	---	---	---	---					
IL21-AS1	100996941	broad.mit.edu	37	4	123563989	123563989	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:123563989delT	ENST00000417927.1	+	0	2797																											gttcctggcATTTTTTTCCTA	0.478													2	4	---	---	---	---					
RP11-775H9.2	0	broad.mit.edu	37	4	137073674	137073674	+	RNA	DEL	T	T	-	rs10710172		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:137073674delT	ENST00000513332.1	-	0	279																											ccacagttactgtcatctgtt	0.522													4	3	---	---	---	---					
LINC00500	0	broad.mit.edu	37	4	139355631	139355631	+	RNA	DEL	A	A	-	rs150356551		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:139355631delA	ENST00000515860.1	+	0	82																											aagcaagagcaaaaaaaatcc	0.338													3	3	---	---	---	---					
RP11-284M14.1	0	broad.mit.edu	37	4	143888856	143888857	+	RNA	INS	-	-	A	rs142729999	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:143888856_143888857insA	ENST00000507826.1	-	0	354																											CGAATTGGTAGAAAAAAAAAAT	0.366													3	3	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190808280	190808280	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr4:190808280delC	ENST00000511785.1	-	0	231																											GAAAGGCAGGCTTAGCCAAGT	0.428													3	4	---	---	---	---					
LOC285696	285696	broad.mit.edu	37	5	17154257	17154258	+	RNA	INS	-	-	A	rs34258260		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:17154257_17154258insA	ENST00000399760.2	-	0	1068					NR_027253.1																						cattttatctcaaaaaaaaaaa	0.495													3	4	---	---	---	---					
RP11-152K4.2	0	broad.mit.edu	37	5	31143385	31143386	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:31143385_31143386insT	ENST00000523584.1	-	0	125																											GCATGCCTTTGTTTTTAATTTA	0.342													2	4	---	---	---	---					
CTD-2194L12.3	0	broad.mit.edu	37	5	37942890	37942891	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:37942890_37942891insC	ENST00000510938.1	-	0	137																											TTCGTTCTCTTCCCCCCCTCCC	0.441													2	4	---	---	---	---					
LOC102467225	102467225	broad.mit.edu	37	5	117963185	117963186	+	RNA	INS	-	-	A	rs148549346	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:117963185_117963186insA	ENST00000503320.1	+	0	300																											TTTAAAAAGTCAAACTTTAAGA	0.287													3	3	---	---	---	---					
MIR143HG	728264	broad.mit.edu	37	5	148794843	148794844	+	RNA	INS	-	-	AG	rs140735875	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:148794843_148794844insAG	ENST00000602964.1	+	0	200																											CTGCAGAGCTCAGTCATACAAT	0.455													3	3	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151388273	151388274	+	RNA	INS	-	-	T	rs145329318	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:151388273_151388274insT	ENST00000524295.1	+	0	199																											gtttcccatgcttttttttatc	0.337													2	4	---	---	---	---					
RP11-541P9.3	0	broad.mit.edu	37	5	162596452	162596452	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:162596452delC	ENST00000509211.1	-	0	117				RP11-541P9.3_ENST00000458002.2_RNA																							acaattgctacaaagagacaa	0.363													2	4	---	---	---	---					
CTC-207P7.1	0	broad.mit.edu	37	5	163598642	163598643	+	RNA	INS	-	-	C	rs13359410	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr5:163598642_163598643insC	ENST00000521805.1	-	0	495																											CCCACCTCCAGCCCCCCAGTGC	0.450													2	4	---	---	---	---					
GPANK1	7918	broad.mit.edu	37	6	31631853	31631854	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:31631853_31631854insC	ENST00000375906.1	-	3	1086_1087	c.402_403insG	c.(400-405)ggatatfs	p.Y135fs	GPANK1_ENST00000375900.4_Frame_Shift_Ins_p.Y135fs|GPANK1_ENST00000375895.2_Frame_Shift_Ins_p.Y135fs|GPANK1_ENST00000375896.4_Frame_Shift_Ins_p.Y135fs|GPANK1_ENST00000375893.2_Frame_Shift_Ins_p.Y135fs	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	135						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						GCGTTGATATTCCCCCCAGCTC	0.634													8	48	---	---	---	---					
TNXB	7148	broad.mit.edu	37	6	32047089	32047089	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:32047089delC	ENST00000375244.3	-	11	4297	c.4096delG	c.(4096-4098)ccfs	p.A1366fs	TNXB_ENST00000375247.2_Frame_Shift_Del_p.A1366fs			P22105	TENX_HUMAN	tenascin XB	1453	Fibronectin type-III 6.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GACTCCGGGGCCTCCGTGCCC	0.642													21	35	---	---	---	---					
LOC101929705	101929705	broad.mit.edu	37	6	44012438	44012439	+	RNA	INS	-	-	ACAC			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:44012438_44012439insACAC	ENST00000422059.1	-	0	156																											cacgctcacatacacacatatt	0.416													3	3	---	---	---	---					
FLJ34503	285759	broad.mit.edu	37	6	114225420	114225421	+	RNA	DEL	TC	TC	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:114225420_114225421delTC	ENST00000314481.3	+	0	119_120					NR_027060.1																						GCCAAGGCATTCTCTCTCTCTC	0.515													2	4	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129725087	129725087	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr6:129725087delC	ENST00000421865.2	+	40	5897	c.5848delC	c.(5848-5850)atfs	p.H1950fs		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1950	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGATCTTGCACATGAAGCTAC	0.393													26	57	---	---	---	---					
LOC101927769	101927769	broad.mit.edu	37	7	20343678	20343679	+	RNA	INS	-	-	A	rs71788919		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:20343678_20343679insA	ENST00000446399.1	+	0	214																											aactccatctcaaaaaaaaaaa	0.431													2	4	---	---	---	---					
AC004009.3	0	broad.mit.edu	37	7	27413595	27413596	+	RNA	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:27413595_27413596insA	ENST00000412413.1	+	0	128																											gcccaagatggaaaaaaacaga	0.366													2	4	---	---	---	---					
INHBA	3624	broad.mit.edu	37	7	41729364	41729365	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:41729364_41729365insT	ENST00000242208.4	-	3	1410_1411	c.1164_1165insA	c.(1162-1167)aacgtgfs	p.NV388fs	INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000442711.1_Frame_Shift_Ins_p.NV388fs	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	388					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ACACAGCACGATTTGAGGTTGG	0.515										TSP Lung(11;0.080)			19	65	---	---	---	---					
INHBA-AS1	285954	broad.mit.edu	37	7	41804281	41804282	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:41804281_41804282insC	ENST00000415848.2	+	0	358					NR_027118.1																						gccatctctctccccatacaca	0.441													2	4	---	---	---	---					
AC073325.1	0	broad.mit.edu	37	7	45516054	45516055	+	RNA	INS	-	-	A	rs34876543	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:45516054_45516055insA	ENST00000443714.1	+	0	259																											TTGTTGTTTTTAAAAAAAactt	0.287													4	3	---	---	---	---					
RP11-3P22.2	0	broad.mit.edu	37	7	68804321	68804321	+	RNA	DEL	A	A	-	rs79062273		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:68804321delA	ENST00000435148.1	-	0	156																											actctgtatcaaaaaaaaaaG	0.483													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72068715	72068716	+	RNA	INS	-	-	A	rs72602977	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:72068715_72068716insA	ENST00000438125.1	-	0	1399							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										atgatgtgatgaaaacggcact	0.426													3	4	---	---	---	---					
LOC101928283	101928283	broad.mit.edu	37	7	124851558	124851559	+	RNA	INS	-	-	T	rs150353716	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:124851558_124851559insT	ENST00000424515.2	+	0	648																											CCTCTATTGCATTTTTTTTTCT	0.307													4	2	---	---	---	---					
FLNC	2318	broad.mit.edu	37	7	128487837	128487838	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr7:128487837_128487838insC	ENST00000325888.8	+	25	4636_4637	c.4375_4376insC	c.(4375-4377)ccgfs	p.P1459fs	FLNC_ENST00000346177.6_Frame_Shift_Ins_p.P1459fs	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1459					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGGTGTCAGGGCCCGGGTTCCT	0.663													14	60	---	---	---	---					
RP11-369E15.3	0	broad.mit.edu	37	8	20827771	20827771	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:20827771delT	ENST00000518967.1	-	0	145																											TCTTCCACCCTACCCCCAACC	0.488													3	3	---	---	---	---					
RP11-459E5.1	0	broad.mit.edu	37	8	22557219	22557220	+	RNA	INS	-	-	AGAAAG	rs13262232		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:22557219_22557220insAGAAAG	ENST00000523627.1	+	0	164																											gaagaaaggaaagaaagaaaga	0.312													3	3	---	---	---	---					
LOC101929470	101929470	broad.mit.edu	37	8	29677949	29677950	+	RNA	INS	-	-	AC			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:29677949_29677950insAC	ENST00000507496.1	-	0	578																											caccacacacaacacacacacc	0.465													3	6	---	---	---	---					
RP11-388G22.1	0	broad.mit.edu	37	8	58533464	58533464	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:58533464delA	ENST00000520426.1	-	0	273																											GAAGAATTTGAAacacacaca	0.358													2	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	65159015	65159016	+	RNA	INS	-	-	A	rs148204389		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:65159015_65159016insA	ENST00000521958.1	-	0	218				RP11-32K4.1_ENST00000523191.1_RNA																							CTCCTTCATTTAAAAAAAAAAA	0.446													6	3	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81227285	81227286	+	RNA	INS	-	-	A	rs78798382		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:81227285_81227286insA	ENST00000522044.1	+	0	404																											accctgcctccaaaaaaaaaaa	0.470													3	4	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89487493	89487494	+	RNA	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:89487493_89487494insA	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							tcaagaacaccaaaaaatcaat	0.381													2	4	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91329987	91329987	+	RNA	DEL	A	A	-	rs71266116		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:91329987delA	ENST00000523406.1	+	0	300					NR_051989.1																						AGCTAAGCACAAAAAAAAGAA	0.368													4	2	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94470802	94470803	+	RNA	DEL	CA	CA	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:94470802_94470803delCA	ENST00000501400.1	-	0	1133					NR_033858.1																						caccctcaagcacacacacaca	0.495													2	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	109920923	109920924	+	RNA	INS	-	-	T	rs147339368	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:109920923_109920924insT	ENST00000524134.1	-	0	431				RP11-1084E5.1_ENST00000522244.1_RNA																							TTATATTACTGTTTTTTTCCCC	0.381													2	4	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	138978428	138978428	+	RNA	DEL	A	A	-	rs75321159		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:138978428delA	ENST00000518973.1	-	0	514																											ACATTGCCAGAAAAAAAAAAA	0.383													3	3	---	---	---	---					
FAM135B	51059	broad.mit.edu	37	8	139153536	139153537	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr8:139153536_139153537insG	ENST00000395297.1	-	17	3864_3865	c.3694_3695insC	c.(3694-3696)gttfs	p.V1232fs		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1232								p.R1232W(2)|p.R1232R(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATACCGGAACCGGGGCCGTGTG	0.535										HNSCC(54;0.14)			34	109	---	---	---	---					
CDKN2B-AS1	100048912	broad.mit.edu	37	9	22120787	22120789	+	RNA	DEL	ATC	ATC	-	rs59052189		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:22120787_22120789delATC	ENST00000428597.1	+	0	3528_3530				CDKN2B-AS1_ENST00000422420.1_RNA	NR_003529.3																						atccatcattatcatcatcatca	0.330													4	2	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68408343	68408343	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:68408343delA	ENST00000417843.2	-	0	67																											acctaaaggtaaaaaaaaatc	0.318													3	5	---	---	---	---					
LINC00476	100128782	broad.mit.edu	37	9	98624697	98624697	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:98624697delT	ENST00000429781.1	-	0	608																											gttgagtttgttttttttttt	0.299													2	4	---	---	---	---					
STX17-AS1	441461	broad.mit.edu	37	9	102651713	102651713	+	RNA	DEL	A	A	-	rs80339979		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:102651713delA	ENST00000529965.1	-	0	174					NR_038853.1																						GTCACAGGGGACATCCATGTC	0.473													2	4	---	---	---	---					
RP11-18B16.2	0	broad.mit.edu	37	9	116431293	116431300	+	RNA	DEL	CTCTCTCT	CTCTCTCT	-	rs35481787		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr9:116431293_116431300delCTCTCTCT	ENST00000428292.1	+	0	273																											ccctctctccctctctctctctctctct	0.476													3	5	---	---	---	---					
LOC101929352	101929352	broad.mit.edu	37	10	31480328	31480329	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:31480328_31480329insC	ENST00000605929.1	+	0	317																											tctggctcccacccccaTTGCA	0.470													2	4	---	---	---	---					
WDR11-AS1	283089	broad.mit.edu	37	10	122574327	122574327	+	RNA	DEL	T	T	-	rs113491242		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr10:122574327delT	ENST00000598981.1	-	0	228					NR_033850.1																						aatctgatggtttttgtaagt	0.453													3	3	---	---	---	---					
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:34904908_34904909insC	ENST00000395787.3	-	6	818_819	c.604_605insG	c.(604-606)aacfs	p.N202fs	APIP_ENST00000527830.1_5'UTR|APIP_ENST00000278359.5_Frame_Shift_Ins_p.N219fs	NM_015957.2	NP_057041.2	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity			kidney(2)|lung(1)|skin(1)	4	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.450													7	875	---	---	---	---					
RP11-164N3.2	0	broad.mit.edu	37	11	87822116	87822116	+	RNA	DEL	A	A	-	rs72508888		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:87822116delA	ENST00000531454.1	-	0	236																											aggagctgacaaaaaaaaaag	0.353													3	4	---	---	---	---					
RP11-64D24.2	0	broad.mit.edu	37	11	114187852	114187853	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:114187852_114187853insG	ENST00000544925.1	-	0	50																											ggactacaaaaggggggacgag	0.465													2	4	---	---	---	---					
LOC101929011	101929011	broad.mit.edu	37	11	116523289	116523290	+	RNA	INS	-	-	TC			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr11:116523289_116523290insTC	ENST00000444123.1	+	0	116																											CCCCTTTACCTTCTCTCTCTca	0.515													2	4	---	---	---	---					
RP11-664D1.1	0	broad.mit.edu	37	12	3998191	3998191	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:3998191delT	ENST00000537149.1	+	0	223																											TTTCtttttctttttttaaat	0.348													2	4	---	---	---	---					
RP11-313F23.4	0	broad.mit.edu	37	12	34345095	34345095	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:34345095delT	ENST00000545923.2	-	0	347																											GTGGCTAAAATTTTAAAAACT	0.403													4	6	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76129583	76129584	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:76129583_76129584insT	ENST00000552856.1	-	0	326																											GAGTTGGAAGGTTTTTGTCTGG	0.376													2	4	---	---	---	---					
MGAT4C	25834	broad.mit.edu	37	12	86373695	86373695	+	Frame_Shift_Del	DEL	G	G	-	rs141479653		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:86373695delG	ENST00000604798.1	-	8	2013	c.809delC	c.(808-810)cafs	p.P270fs	MGAT4C_ENST00000548651.1_Frame_Shift_Del_p.P270fs|MGAT4C_ENST00000549405.2_Frame_Shift_Del_p.P270fs|MGAT4C_ENST00000552808.2_Frame_Shift_Del_p.P270fs|MGAT4C_ENST00000332156.1_Frame_Shift_Del_p.P270fs|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000393205.2_Frame_Shift_Del_p.P299fs			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	270					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GGCCAAACGTGGGAGATCATG	0.388													10	35	---	---	---	---					
RP11-510I5.4	0	broad.mit.edu	37	12	96851764	96851765	+	RNA	INS	-	-	T	rs34968371		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:96851764_96851765insT	ENST00000548740.1	-	0	226																											AATTTAAtttcttttttttttt	0.396													4	2	---	---	---	---					
DRAM1	55332	broad.mit.edu	37	12	102355350	102355350	+	RNA	DEL	T	T	-	rs35607335		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:102355350delT	ENST00000550307.1	-	0	141																											ACTGTTGTAATTTTTTTCACG	0.323													6	2	---	---	---	---					
RP3-473L9.4	0	broad.mit.edu	37	12	111818720	111818721	+	RNA	DEL	AC	AC	-	rs72274320		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:111818720_111818721delAC	ENST00000552663.1	+	0	141																											CCCCAGAAAGacacacacacac	0.520													3	6	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132466655	132466656	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr12:132466655_132466656insG	ENST00000333577.4	+	6	1778_1779	c.1669_1670insG	c.(1669-1671)gcafs	p.A557fs	EP400_ENST00000330386.6_Frame_Shift_Ins_p.A521fs|EP400_ENST00000389562.2_Frame_Shift_Ins_p.A520fs|EP400_ENST00000332482.4_Frame_Shift_Ins_p.A484fs|EP400_ENST00000389561.2_Frame_Shift_Ins_p.A521fs			Q96L91	EP400_HUMAN	E1A binding protein p400	557					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCCCCCCACGCCGCAGGCCGCG	0.589													26	82	---	---	---	---					
LINC00426	100188949	broad.mit.edu	37	13	30935106	30935107	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:30935106_30935107insG	ENST00000447147.1	-	0	390					NR_024464.1																						CAAGAGACCTAGGGGGGAGGTT	0.530													5	1	---	---	---	---					
LINC00402	100507612	broad.mit.edu	37	13	74828914	74828915	+	RNA	DEL	TG	TG	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:74828914_74828915delTG	ENST00000419499.1	+	0	296																											TTtgcgtgtatgtgtgtgtgtg	0.406													2	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101556593	101556593	+	RNA	DEL	A	A	-	rs74360192		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:101556593delA	ENST00000457843.1	+	0	141					NR_047687.1																						ggtgaaaaggaaaaaaaaaaa	0.423													2	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101704029	101704030	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:101704029_101704030insG	ENST00000457843.1	+	0	480					NR_047687.1																						TCTTGTGGGCTGGGGGTATCTG	0.460													2	4	---	---	---	---					
CCDC168	643677	broad.mit.edu	37	13	103389011	103389011	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr13:103389011delT	ENST00000322527.2	-	1	148	c.149delA	c.(148-150)agfs	p.K50fs		NM_001146197.1	NP_001139669.1			coiled-coil domain containing 168									p.K50R(2)									TTCTTGTGCCTTTTCCCCTTG	0.413													2	4	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26439291	26439291	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:26439291delG	ENST00000546412.1	-	0	258																											AAATTAAAAAGGGCATGGTTG	0.294													3	6	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26510131	26510131	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:26510131delT	ENST00000546412.1	-	0	258																											aatcttgctctttctctctct	0.488													2	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	27812932	27812954	+	RNA	DEL	TACAGGGGCAGAGCTGTCCAAGG	TACAGGGGCAGAGCTGTCCAAGG	-	rs111366051		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:27812932_27812954delTACAGGGGCAGAGCTGTCCAAGG	ENST00000553392.1	-	0	262																											cctgcaaagctacaggggcagagctgtccaaggttgtgggaat	0.489													2	4	---	---	---	---					
RP11-1103G16.1	0	broad.mit.edu	37	14	30980246	30980246	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:30980246delA	ENST00000552511.1	-	0	222																											AATAAGAATGAAAAAAAAAAA	0.259													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43127981	43127981	+	RNA	DEL	G	G	-	rs74415587		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:43127981delG	ENST00000557251.1	+	0	166																											GAACAGTGAAGGGGGTCTTTC	0.428													5	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44836609	44836610	+	RNA	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:44836609_44836610insA	ENST00000553827.1	-	0	69																											ATTCCAAAAAGAAAAAAAGAGA	0.376													2	4	---	---	---	---					
RP11-218E20.2	0	broad.mit.edu	37	14	51315058	51315058	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:51315058delC	ENST00000557152.1	+	0	28																											cagtgaccagcccccatgtag	0.468													4	3	---	---	---	---					
RP11-516J2.1	0	broad.mit.edu	37	14	76776030	76776030	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:76776030delG	ENST00000555465.1	-	0	242																											CCCTCTTGAAGGGGAAACTCA	0.433													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82325792	82325793	+	RNA	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr14:82325792_82325793insA	ENST00000554814.1	+	0	315																											ctttcatgtataaaaaaagaga	0.411													2	4	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20614996	20614999	+	RNA	DEL	TTTG	TTTG	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:20614996_20614999delTTTG	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCCTCACTTATTTGTTTGTTTAtt	0.392													3	5	---	---	---	---					
NBEAP1	606	broad.mit.edu	37	15	20874039	20874039	+	RNA	DEL	A	A	-	rs56006019		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:20874039delA	ENST00000556948.1	-	0	452																											TAAACAAATCAAAGATGGAGG	0.254													3	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22331187	22331188	+	RNA	INS	-	-	A	rs137940619		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:22331187_22331188insA	ENST00000558896.1	+	0	194																											TGATTCTAGATAAAAAAAAATT	0.302													6	0	---	---	---	---					
RP11-184D12.1	0	broad.mit.edu	37	15	36378825	36378825	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:36378825delG	ENST00000561394.1	-	0	136																											gaagaatcaagggagatgaaa	0.517													2	4	---	---	---	---					
RP11-346D14.1	0	broad.mit.edu	37	15	38481427	38481428	+	RNA	INS	-	-	A	rs77624696	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:38481427_38481428insA	ENST00000561320.1	-	0	222																											CAACTGAAAGGAAAAAAAAAAC	0.366													2	4	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61884590	61884591	+	RNA	INS	-	-	A	rs75950131	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:61884590_61884591insA	ENST00000559783.1	-	0	35																											TAAAAAAGGAGAAAAAAACCCA	0.312													2	4	---	---	---	---					
RP11-429B14.1	0	broad.mit.edu	37	15	90085975	90085976	+	RNA	INS	-	-	T	rs10633318		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:90085975_90085976insT	ENST00000559041.1	+	0	47																											AGACAAGGCTCttttttttttt	0.441													5	4	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92806527	92806528	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:92806527_92806528insT	ENST00000561674.1	-	0	185																											ctttttcattatttttggccat	0.366													2	4	---	---	---	---					
FAM174B	400451	broad.mit.edu	37	15	93250230	93250231	+	RNA	INS	-	-	A	rs147949734	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr15:93250230_93250231insA	ENST00000554000.2	-	0	116																											CATCTATGGGGAAAAAAAAAGG	0.446													2	4	---	---	---	---					
LOC101927009	101927009	broad.mit.edu	37	16	9495345	9495347	+	RNA	DEL	ATC	ATC	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:9495345_9495347delATC	ENST00000564305.1	+	0	193																											catcaccattatcatcataatct	0.414													3	3	---	---	---	---					
RP11-876N24.2	0	broad.mit.edu	37	16	10961101	10961101	+	RNA	DEL	A	A	-	rs34055460		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:10961101delA	ENST00000572017.1	-	0	438																											actccatctcaaaaaaaaaaa	0.512													4	3	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32117098	32117098	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:32117098delA	ENST00000564145.1	-	0	456																											aataggaaagaaaggaaagaa	0.383													4	5	---	---	---	---					
LOC101927650	101927650	broad.mit.edu	37	16	65184731	65184732	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:65184731_65184732insC	ENST00000563754.1	-	0	406																											ctgatgggaaacccccctgttc	0.441													2	4	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80196054	80196058	+	RNA	DEL	AAATT	AAATT	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:80196054_80196058delAAATT	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA																							ATTATGTCTCAAATTAAACATACTA	0.366													2	4	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81159575	81159576	+	RNA	INS	-	-	T			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr16:81159575_81159576insT	ENST00000533478.1	-	0	4405				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCATGGTGTGGttttttgttgg	0.515													2	4	---	---	---	---					
LINC00670	284034	broad.mit.edu	37	17	12462495	12462506	+	RNA	DEL	TCCTTCCTTCCT	TCCTTCCTTCCT	-	rs9916267	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:12462495_12462506delTCCTTCCTTCCT	ENST00000313495.2	+	0	296					NR_034144.1|NR_034145.1																						CTATAGATTCtccttccttccttccttccttc	0.571													2	4	---	---	---	---					
CTD-2377D24.8	0	broad.mit.edu	37	17	46777560	46777560	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:46777560delG	ENST00000575202.1	+	0	51																											AGGAAGGGATGGGGAAGAAGA	0.562													6	11	---	---	---	---					
MAP3K3	4215	broad.mit.edu	37	17	61769652	61769652	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr17:61769652delG	ENST00000361357.3	+	16	1936	c.1618delG	c.(1618-1620)ggfs	p.G540fs	MAP3K3_ENST00000579585.1_Frame_Shift_Del_p.G540fs|MAP3K3_ENST00000577395.1_Frame_Shift_Del_p.G505fs|MAP3K3_ENST00000361733.3_Frame_Shift_Del_p.G509fs|MAP3K3_ENST00000584573.1_Frame_Shift_Del_p.G536fs	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	509	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						GGGGGACTTTGGGGCCAGCAA	0.597													7	28	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112443	112443	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:112443delC	ENST00000576266.1	+	0	77																											TAAAGCTCCTCCAGCAGAGCC	0.692													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37181759	37181760	+	RNA	DEL	AC	AC	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:37181759_37181760delAC	ENST00000591629.1	-	0	282					NR_024391.1																						acagacacagacacacacacac	0.351													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37247673	37247674	+	RNA	DEL	CA	CA	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:37247673_37247674delCA	ENST00000591629.1	-	0	282					NR_024391.1																						TGcacacacgcacacacacaca	0.406													3	4	---	---	---	---					
SETBP1	26040	broad.mit.edu	37	18	42532214	42532214	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:42532214delC	ENST00000282030.5	+	4	3205	c.2909delC	c.(2908-2910)tcfs	p.S970fs		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	970						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TTCAGAATCTCCCACCGGAGT	0.473									Schinzel-Giedion syndrome				45	95	---	---	---	---					
RP11-846C15.2	0	broad.mit.edu	37	18	42751798	42751799	+	RNA	INS	-	-	A	rs151022100	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:42751798_42751799insA	ENST00000589845.1	-	0	290				RP11-846C15.2_ENST00000587276.1_RNA																							TAAATTCTGTCTGAATCACTCA	0.396													3	4	---	---	---	---					
RP11-795H16.3	0	broad.mit.edu	37	18	57810244	57810245	+	RNA	INS	-	-	A	rs71881142		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:57810244_57810245insA	ENST00000588794.1	+	0	346																											actccatctccaaaaaaaaaga	0.455													3	6	---	---	---	---					
LOC284294	284294	broad.mit.edu	37	18	61999535	61999536	+	RNA	INS	-	-	A	rs33959630	by1000genomes	TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:61999535_61999536insA	ENST00000589376.1	+	0	580					NR_033881.1																						ctgccctggggtaacttccaga	0.495													4	3	---	---	---	---					
RP11-25L3.3	0	broad.mit.edu	37	18	71690515	71690516	+	RNA	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr18:71690515_71690516insG	ENST00000581541.1	-	0	121																											tctgacaagcagggaaggccaa	0.495													2	4	---	---	---	---					
LOC284395	284395	broad.mit.edu	37	19	29970516	29970516	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:29970516delC	ENST00000582581.1	-	0	329					NR_040029.1																						CCCAACACTTCCAGGATCCTT	0.428													7	8	---	---	---	---					
FFAR1	2864	broad.mit.edu	37	19	35843336	35843337	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:35843336_35843337insG	ENST00000246553.2	+	1	892_893	c.882_883insG	c.(880-885)caggggfs	p.QG294fs		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	294					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	CAAGAACGCAAGGGGGCAAGTC	0.653													2	4	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57205352	57205355	+	RNA	DEL	TGTG	TGTG	-	rs71652919		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr19:57205352_57205355delTGTG	ENST00000597822.1	+	0	60																											ACTAtgtgtatgtgtgtgtgtgtg	0.387													3	3	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10950913	10950916	+	RNA	DEL	AAAG	AAAG	-	rs55940662		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:10950913_10950916delAAAG	ENST00000605292.1	+	0	439																											GCATCAGGGTAAAGATTAAACATT	0.377													6	0	---	---	---	---					
RALY	22913	broad.mit.edu	37	20	32669246	32669246	+	RNA	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:32669246delG	ENST00000434926.1	+	0	79																											TCTCTCCTCTGGAAGCCTTCC	0.493													2	4	---	---	---	---					
RN7SL680P	0	broad.mit.edu	37	20	37977820	37977820	+	RNA	DEL	T	T	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:37977820delT	ENST00000583513.1	-	0	215																											agcatgggaattttgacctgc	0.468													2	4	---	---	---	---					
SEMG1	6406	broad.mit.edu	37	20	43836227	43836228	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:43836227_43836228insA	ENST00000372781.3	+	2	346_347	c.289_290insA	c.(289-291)acgfs	p.T97fs	SEMG1_ENST00000244069.6_Frame_Shift_Ins_p.T97fs	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GACAAAATCACAACGACATCTA	0.376													37	86	---	---	---	---					
ZBTB46	140685	broad.mit.edu	37	20	62407137	62407138	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr20:62407137_62407138delCG	ENST00000245663.4	-	3	1265_1266	c.1115_1116delCG	c.(1114-1116)gfs	p.A373fs	ZBTB46_ENST00000395104.1_Frame_Shift_Del_p.A373fs|ZBTB46_ENST00000302995.2_Frame_Shift_Del_p.A373fs	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					TCATGAGCGCCGCGCGCAGGTT	0.673													6	10	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11042864	11042867	+	RNA	DEL	AGTA	AGTA	-	rs56773804		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:11042864_11042867delAGTA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		caatattaatagtaagtaagctta	0.358													5	10	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11082166	11082166	+	RNA	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:11082166delC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		atttttgctgcccaagggaca	0.468													4	8	---	---	---	---					
CYP4F29P	54055	broad.mit.edu	37	21	15220616	15220620	+	RNA	DEL	GAAAG	GAAAG	-	rs71182489		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:15220616_15220620delGAAAG	ENST00000428301.1	-	0	65_69					NR_026755.1|NR_047508.1																						CAGTGCTTCTGAAAGGAAAGGTTTC	0.527													5	6	---	---	---	---					
LOC339622	339622	broad.mit.edu	37	21	26401256	26401257	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:26401256_26401257insC	ENST00000441009.1	+	0	330					NR_046198.3																						cacacacaccacccccccacac	0.406													2	4	---	---	---	---					
AF131217.1	0	broad.mit.edu	37	21	29970909	29970910	+	RNA	INS	-	-	TTATT			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:29970909_29970910insTTATT	ENST00000433310.1	-	0	294																											tttctcttagcttattttaatg	0.421													2	4	---	---	---	---					
AP000282.2	0	broad.mit.edu	37	21	34371425	34371425	+	RNA	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr21:34371425delA	ENST00000420356.1	-	0	201				AP000282.2_ENST00000454622.1_RNA																							aaaggcaaggaaaaaaaaaga	0.338													2	4	---	---	---	---					
GGT3P	2679	broad.mit.edu	37	22	18771547	18771547	+	RNA	DEL	G	G	-	rs149629602		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:18771547delG	ENST00000412448.1	-	0	834																											TTTTTGttttgtttttttttt	0.433													5	4	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35432289	35432290	+	RNA	DEL	CT	CT	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chr22:35432289_35432290delCT	ENST00000448318.4	-	0	686																											ttctctctccctctctctctct	0.470													3	6	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22986603	22986604	+	RNA	INS	-	-	C			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:22986603_22986604insC	ENST00000455399.1	-	0	82																											TTCCTCTCCTTCCCCCCCACCA	0.455													3	4	---	---	---	---					
ZCCHC13	389874	broad.mit.edu	37	X	73524478	73524478	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:73524478delC	ENST00000339534.2	+	1	454	c.377delC	c.(376-378)gcfs	p.A126fs		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	126							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						AAAGACTGCGCCCAGGTCAAG	0.562													22	33	---	---	---	---					
BEX1	55859	broad.mit.edu	37	X	102318116	102318116	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:102318116delA	ENST00000372728.3	-	3	326	c.87delT	c.(85-87)aafs	p.N29fs		NM_018476.3	NP_060946.3	Q9HBH7	BEX1_HUMAN	brain expressed, X-linked 1	29					cell differentiation|nervous system development	cytoplasm|nucleus				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12						GCTCCCCTTTATTAGCAACTT	0.488													96	279	---	---	---	---					
AMOT	154796	broad.mit.edu	37	X	112054567	112054567	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:112054567delA	ENST00000371959.3	-	3	1446	c.1447delT	c.(1447-1449)ccfs	p.S484fs	AMOT_ENST00000304758.1_Frame_Shift_Del_p.S75fs|AMOT_ENST00000524145.1_Frame_Shift_Del_p.S484fs|AMOT_ENST00000371958.1_Frame_Shift_Del_p.S252fs|AMOT_ENST00000371962.1_Frame_Shift_Del_p.S252fs	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	484					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						CTTTTGGAGGATGACTTCACG	0.493													14	225	---	---	---	---					
RAP2C-AS1	101928578	broad.mit.edu	37	X	131487757	131487758	+	RNA	INS	-	-	T	rs138369103		TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:131487757_131487758insT	ENST00000441399.1	+	0	424				RP5-842K24.2_ENST00000421483.1_RNA																							CCTTATATAGGTTTTTTTTTTT	0.376													4	5	---	---	---	---					
HS6ST2	90161	broad.mit.edu	37	X	131762582	131762582	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:131762582delA	ENST00000370836.2	-	4	1902	c.1487delT	c.(1486-1488)tgfs	p.L496fs	HS6ST2_ENST00000406696.3_Frame_Shift_Del_p.L222fs|HS6ST2_ENST00000370837.1_Frame_Shift_Del_p.L350fs|HS6ST2_ENST00000521489.1_Frame_Shift_Del_p.L536fs|HS6ST2_ENST00000370833.2_Frame_Shift_Del_p.L390fs	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	496						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					ATACCTCTGCAAAAAAAGGTC	0.453													7	375	---	---	---	---					
GPR101	83550	broad.mit.edu	37	X	136113576	136113576	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z045-01A-01W-0746-08	TCGA-17-Z045-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ec7e65c5-7158-427f-8034-8616077da50b	9264321f-654e-432e-9c12-78ee2c52dff5	g.chrX:136113576delG	ENST00000298110.1	-	1	257	c.258delC	c.(256-258)ccfs	p.P86fs		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CCACCACCCAGGGGGCCACGA	0.617													28	74	---	---	---	---					
