Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TDRD7	23424	broad.mit.edu	37	9	100243134	100243134	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:100243134C>G	ENST00000355295.4	+	14	2621	c.2326C>G	c.(2326-2328)Ctt>Gtt	p.L776V	TDRD7_ENST00000492428.1_3'UTR|TDRD7_ENST00000540902.1_Missense_Mutation_p.L96V|TDRD7_ENST00000422139.2_Missense_Mutation_p.L702V	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	776					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				TTTAGCAGATCTTCCACAATC	0.358000													174	280					0	0	0.048971	0	0
CHST6	4166	broad.mit.edu	37	16	75513119	75513119	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:75513119T>A	ENST00000332272.4	-	3	787	c.608A>T	c.(607-609)gAc>gTc	p.D203V	CHST6_ENST00000390664.2_Missense_Mutation_p.D203V|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	203			D -> E (in MCD; abolishes ability to sulfate keratan; dbSNP:rs28937878).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGCCCGCGGGTCGCGCACCAG	0.687000													8	1					0	0	0.047766	0	0
NRG2	9542	broad.mit.edu	37	5	139232109	139232109	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:139232109G>T	ENST00000541337.1	-	6	1483	c.1254C>A	c.(1252-1254)gtC>gtA	p.V418V	NRG2_ENST00000394770.1_3'UTR|CTB-35F21.4_ENST00000504413.1_RNA|NRG2_ENST00000361474.1_Silent_p.V484V|NRG2_ENST00000545385.1_Silent_p.V486V|NRG2_ENST00000289409.4_Silent_p.V478V|NRG2_ENST00000289422.7_Silent_p.V492V|NRG2_ENST00000358522.3_Silent_p.V486V|NRG2_ENST00000340391.3_Silent_p.V281V	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	484					embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCCTGATGACATGGTCTG	0.542000													53	84					1.25742e-37	1.93471e-37	0.048971	1	0
SLC4A3	6508	broad.mit.edu	37	2	220504305	220504305	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:220504305G>T	ENST00000358055.3	+	20	3637	c.3125G>T	c.(3124-3126)gGg>gTg	p.G1042V	SLC4A3_ENST00000373760.2_Missense_Mutation_p.G1042V|SLC4A3_ENST00000273063.6_Missense_Mutation_p.G1069V|SLC4A3_ENST00000317151.3_Missense_Mutation_p.G1042V|SLC4A3_ENST00000373762.3_Missense_Mutation_p.G1069V			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1042	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGCTGTTTGGGTTGCCCTGG	0.637000													18	54					1.66031e-10	1.90836e-10	0.091800	1	0
UBE2NL	389898	broad.mit.edu	37	X	142967530	142967530	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:142967530C>G	ENST00000370494.1	+	1	358	c.328C>G	c.(328-330)Cag>Gag	p.Q110E		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	110							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GCTATCGATCCAGGCCTTGTT	0.438000													188	13					0	0	0.048971	0	0
INPP4A	3631	broad.mit.edu	37	2	99203983	99203983	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:99203983G>T	ENST00000074304.5	+	26	3239	c.2846G>T	c.(2845-2847)cGc>cTc	p.R949L	INPP4A_ENST00000523221.1_Missense_Mutation_p.R949L|INPP4A_ENST00000545415.1_Missense_Mutation_p.R910L|INPP4A_ENST00000409016.3_Missense_Mutation_p.R910L|INPP4A_ENST00000409463.1_Missense_Mutation_p.R278L|INPP4A_ENST00000409851.3_Missense_Mutation_p.R944L	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	949					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						GTTGGAAGTCGCAAATATGCA	0.423000													27	28					7.07758e-08	7.74075e-08	0.099896	1	0
MICAL1	64780	broad.mit.edu	37	6	109769445	109769445	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:109769445G>T	ENST00000368952.4	-	13	2163	c.1873C>A	c.(1873-1875)Cac>Aac	p.H625N	MICAL1_ENST00000358807.3_Missense_Mutation_p.H606N|MICAL1_ENST00000358577.3_Missense_Mutation_p.H520N			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	606					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CTGTGGAAGTGGCTGAGGTAG	0.592000													66	43					8.83742e-36	1.33846e-35	0.048971	1	0
AHNAK2	113146	broad.mit.edu	37	14	105416572	105416572	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:105416572C>A	ENST00000333244.5	-	7	5335	c.5216G>T	c.(5215-5217)gGg>gTg	p.G1739V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1739						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGAGGTGCCCTTTGAAGCC	0.637000													22	33					7.41877e-09	8.26071e-09	0.062417	1	0
PTPRD	5789	broad.mit.edu	37	9	8521415	8521415	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:8521415C>A	ENST00000381196.4	-	17	1366	c.823G>T	c.(823-825)Gat>Tat	p.D275Y	PTPRD_ENST00000360074.4_Missense_Mutation_p.D262Y|PTPRD_ENST00000486161.1_Missense_Mutation_p.D275Y|PTPRD_ENST00000537002.1_Missense_Mutation_p.D272Y|PTPRD_ENST00000356435.5_Missense_Mutation_p.D275Y|PTPRD_ENST00000355233.5_Missense_Mutation_p.D275Y|PTPRD_ENST00000358503.5_Missense_Mutation_p.D262Y|PTPRD_ENST00000397606.3_Missense_Mutation_p.D265Y|PTPRD_ENST00000397611.3_Missense_Mutation_p.D272Y|PTPRD_ENST00000397617.3_Missense_Mutation_p.D265Y|PTPRD_ENST00000540109.1_Missense_Mutation_p.D275Y	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	275	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.D275N(4)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGTGTCAGATCTTCTGCCCCC	0.448000										TSP Lung(15;0.13)			51	95					7.47603e-22	1.00422e-21	0.048971	1	0
CCT3	7203	broad.mit.edu	37	1	156287236	156287236	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:156287236C>T	ENST00000295688.3	-	9	1142	c.862G>A	c.(862-864)Gat>Aat	p.D288N	CCT3_ENST00000368259.2_Missense_Mutation_p.D250N|CCT3_ENST00000368261.3_Missense_Mutation_p.D243N|CCT3_ENST00000472765.2_Missense_Mutation_p.D243N	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	288					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					ATGACCACATCGGGCTTCAGT	0.488000													5	479					0	0	0.014758	0	0
INHBC	3626	broad.mit.edu	37	12	57828906	57828906	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:57828906C>T	ENST00000309668.2	+	1	364	c.237C>T	c.(235-237)ctC>ctT	p.L79L	INHBC_ENST00000550133.1_Silent_p.L79L	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	79					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TGCAGCACCTCCACGGGGTCC	0.562000													42	74					0	0	0.098360	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925989	54925989	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:54925989C>A	ENST00000293373.6	+	26	2896	c.2817C>A	c.(2815-2817)ccC>ccA	p.P939P	NCKAP1L_ENST00000545638.2_Silent_p.P889P	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	939					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTATGGGTCCCATTGAGTGCT	0.423000													97	84					3.11409e-38	4.83541e-38	0.048971	1	0
PRRC2B	84726	broad.mit.edu	37	9	134340162	134340162	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:134340162G>T	ENST00000357304.4	+	11	1472	c.1417G>T	c.(1417-1419)Ggc>Tgc	p.G473C	PRRC2B_ENST00000458550.1_Missense_Mutation_p.G473C|PRRC2B_ENST00000405995.1_Missense_Mutation_p.G473C|PRRC2B_ENST00000372249.1_5'UTR	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	473							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						GTCATCAATGGGCAGCATGTT	0.572000													10	15					7.48243e-07	8.09202e-07	0.058154	1	0
UGT1A10	54575	broad.mit.edu	37	2	234545533	234545533	+	Missense_Mutation	SNP	C	C	T	rs145610800		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:234545533C>T	ENST00000344644.5	+	1	434	c.365C>T	c.(364-366)tCg>tTg	p.S122L	UGT1A10_ENST00000373445.1_Missense_Mutation_p.S122L|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTATTTTTTTCGCATTGCAGG	0.363000													103	96					0	0	0.048971	0	0
CD1C	911	broad.mit.edu	37	1	158260984	158260984	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:158260984G>C	ENST00000368170.3	+	2	401	c.122G>C	c.(121-123)tGg>tCg	p.W41S		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	41					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					AACCAATCCTGGGCACGAGGT	0.493000													112	133					0	0	0.048971	0	0
ZNF7	7553	broad.mit.edu	37	8	146068327	146068327	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:146068327A>G	ENST00000528372.1	+	5	2075	c.1835A>G	c.(1834-1836)tAt>tGt	p.Y612C	ZNF7_ENST00000325217.5_Intron|ZNF7_ENST00000525266.1_Intron|ZNF7_ENST00000325241.6_Missense_Mutation_p.Y612C|ZNF7_ENST00000446747.2_Missense_Mutation_p.Y623C|ZNF7_ENST00000544249.1_Missense_Mutation_p.Y516C			P17097	ZNF7_HUMAN	zinc finger protein 7	612					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(5)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TTTTACGAATATGGGAATGCC	0.448000													50	65					0	0	0.048971	0	0
ERBB2	2064	broad.mit.edu	37	17	37879576	37879576	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:37879576C>G	ENST00000406381.2	+	19	2371	c.1861C>G	c.(1861-1863)Ctg>Gtg	p.L621V	ERBB2_ENST00000269571.5_Missense_Mutation_p.L651V|ERBB2_ENST00000584601.1_Missense_Mutation_p.L621V|ERBB2_ENST00000584450.1_Missense_Mutation_p.L651V|ERBB2_ENST00000541774.1_Missense_Mutation_p.L636V|ERBB2_ENST00000540147.1_Missense_Mutation_p.L621V|ERBB2_ENST00000445658.2_Missense_Mutation_p.L375V	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	651					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CCCCAGCCCTCTGACGTCCAT	0.607000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			141	129					0	0	0.048971	0	0
TRPC3	7222	broad.mit.edu	37	4	122825509	122825509	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:122825509C>A	ENST00000264811.5	-	7	2420	c.2002G>T	c.(2002-2004)Gct>Tct	p.A668S	TRPC3_ENST00000379645.3_Missense_Mutation_p.A741S|TRPC3_ENST00000513531.1_Missense_Mutation_p.A613S	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	656					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TTAATCATAGCAATTAGCATG	0.323000													5	18					2.0095e-06	2.14918e-06	0.029380	1	0
ZZEF1	23140	broad.mit.edu	37	17	4045901	4045901	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:4045901G>C	ENST00000381638.2	-	1	413	c.289C>G	c.(289-291)Ctg>Gtg	p.L97V	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	97							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AACTGCTCCAGAGTGACAGAC	0.706000													15	12					0	0	0.038395	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849344	98849344	+	RNA	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:98849344C>A	ENST00000554295.1	-	0	1579					NR_033801.1																						CGTGCCTCCTCCAATGATCCA	0.517000													12	10					1.5842e-08	1.75533e-08	0.105934	1	0
TENM4	26011	broad.mit.edu	37	11	78381572	78381572	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:78381572G>C	ENST00000278550.7	-	32	6280	c.5818C>G	c.(5818-5820)Cag>Gag	p.Q1940E		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TACTGCCTCTGGCTGTGTAGT	0.537000													69	69					0	0	0.048971	0	0
WDR70	55100	broad.mit.edu	37	5	37381788	37381788	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:37381788G>T	ENST00000265107.4	+	3	331		c.e3+1		WDR70_ENST00000504564.1_Splice_Site	NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70											central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAACACTGGGTAAGAAGCTC	0.378000													63	66					2.50483e-33	3.71065e-33	0.048971	1	0
PRSS48	345062	broad.mit.edu	37	4	152212601	152212601	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:152212601G>A	ENST00000455694.2	+	5	985	c.983G>A	c.(982-984)aGa>aAa	p.R328K	SH3D19_ENST00000604030.1_Intron|PRSS48_ENST00000441586.2_Missense_Mutation_p.R185K	NM_183375.2	NP_899231.2	Q7RTY5	PRS48_HUMAN	protease, serine, 48	328					proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8						CCCAGGGGCAGATAACTCACA	0.428000													24	23					0	0	0.076483	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175182	143175182	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:143175182A>G	ENST00000408916.1	+	1	217	c.217A>G	c.(217-219)Aag>Gag	p.K73E	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	73					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CTCTGCCCAGAAGGTCGAGTA	0.557000													74	228					0	0	0.048971	0	0
RFX1	5989	broad.mit.edu	37	19	14080874	14080874	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:14080874G>A	ENST00000254325.4	-	10	1662	c.1428C>T	c.(1426-1428)aaC>aaT	p.N476N		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	476					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			AGGAGGCGGCGTTGACGGGCT	0.632000													21	28					0	0	0.045705	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420315	69420315	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:69420315A>G	ENST00000357336.3	+	13	1486	c.1205A>G	c.(1204-1206)aAt>aGt	p.N402S		NM_001098805.1	NP_001092275.1	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	402										breast(1)|large_intestine(1)|liver(1)|lung(9)|pancreas(2)|skin(2)	16						CTTTCAGAAAATATATGTGAT	0.294000													8	63					0	0	0.080935	0	0
SARDH	1757	broad.mit.edu	37	9	136573445	136573445	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:136573445C>A	ENST00000371872.4	-	11	1691	c.1434G>T	c.(1432-1434)ctG>ctT	p.L478L	SARDH_ENST00000439388.1_Silent_p.L478L|SARDH_ENST00000422262.2_Silent_p.L310L	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	478					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGCGCCCGGCCAGCGGCTCAT	0.657000													10	34					2.37509e-13	2.8662e-13	0.055883	1	0
TAOK3	51347	broad.mit.edu	37	12	118599693	118599693	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:118599693T>A	ENST00000392533.3	-	18	2529	c.2039A>T	c.(2038-2040)cAg>cTg	p.Q680L	TAOK3_ENST00000419821.2_Missense_Mutation_p.Q680L|TAOK3_ENST00000537952.1_Missense_Mutation_p.Q220L	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	680					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGTTCCGTCTGGTGCTGTAA	0.502000													73	158					0	0	0.048971	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802533	185802533	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:185802533G>T	ENST00000302277.6	+	4	3004	c.2410G>T	c.(2410-2412)Gct>Tct	p.A804S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	804						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TACTTCAGTTGCTCCCTGCAA	0.383000													35	89					9.17885e-22	1.23051e-21	0.059317	1	0
ACAN	176	broad.mit.edu	37	15	89385034	89385034	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:89385034G>A	ENST00000439576.2	+	5	1067	c.693G>A	c.(691-693)agG>agA	p.R231R	ACAN_ENST00000352105.7_Silent_p.R231R|ACAN_ENST00000561243.1_Silent_p.R231R|ACAN_ENST00000558207.1_Silent_p.R231R|ACAN_ENST00000559004.1_Silent_p.R231R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	231					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGTGTGAGGACGTATGGCA	0.592000													67	84					0	0	0.048971	0	0
FCAR	2204	broad.mit.edu	37	19	55399520	55399520	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:55399520C>A	ENST00000355524.3	+	4	518	c.508C>A	c.(508-510)Caa>Aaa	p.Q170K	FCAR_ENST00000391725.3_Missense_Mutation_p.Q170K|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000359272.4_Missense_Mutation_p.Q158K|FCAR_ENST00000353758.4_Missense_Mutation_p.Q61K|FCAR_ENST00000391723.3_Missense_Mutation_p.Q158K|FCAR_ENST00000469767.1_Missense_Mutation_p.Q170K|FCAR_ENST00000391724.3_Missense_Mutation_p.Q158K|FCAR_ENST00000345937.4_Intron|FCAR_ENST00000482092.2_3'UTR	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	170	Ig-like C2-type 2.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		GCCACAGCACCAAAGTGGGGA	0.527000													29	29					3.1745e-13	3.79706e-13	0.037714	1	0
NLRP13	126204	broad.mit.edu	37	19	56424114	56424114	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:56424114C>G	ENST00000588751.1	-	5	1093	c.1069G>C	c.(1069-1071)Gct>Cct	p.A357P	NLRP13_ENST00000342929.3_Missense_Mutation_p.A357P			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	357	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AGTAAGGTAGCCAGGGGAACC	0.473000													83	140					0	0	0.048971	0	0
NOV	4856	broad.mit.edu	37	8	120429208	120429208	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:120429208G>T	ENST00000259526.3	+	2	536	c.310_splice	c.e2+1	p.T103_splice		NM_002514.3	NP_002505.1	P48745	NOV_HUMAN	nephroblastoma overexpressed	103	IGFBP N-terminal.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(3)	21	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCATCTGCACGGGTAATCCTG	0.577000											OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					9.70103e-10	1.1001e-09	0.069234	1	0
CNTNAP3B	728577	broad.mit.edu	37	9	43861031	43861031	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:43861031C>T	ENST00000377564.3	+	13	2298	c.1905C>T	c.(1903-1905)caC>caT	p.H635H		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	635	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						TGGTGCGGCACGGTGGCCCCG	0.711000													3	17					0	0	0.014758	0	0
GPR158	57512	broad.mit.edu	37	10	25861792	25861792	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:25861792C>T	ENST00000376351.3	+	7	2088	c.1729C>T	c.(1729-1731)Cgc>Tgc	p.R577C		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	577						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCTCATTGACCGCTGGGACTA	0.423000													45	86					0	0	0.048971	0	0
CSMD3	114788	broad.mit.edu	37	8	113421257	113421257	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:113421257C>A	ENST00000297405.5	-	33	5644	c.5400G>T	c.(5398-5400)gtG>gtT	p.V1800V	CSMD3_ENST00000455883.2_Silent_p.V1696V|CSMD3_ENST00000352409.3_Intron|CSMD3_ENST00000343508.3_Silent_p.V1760V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1800	CUB 10.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACTGGCCAAACACCACTGATC	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			101	104					9.94044e-53	1.65756e-52	0.048971	1	0
OR2M5	127059	broad.mit.edu	37	1	248309178	248309178	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:248309178T>C	ENST00000366476.1	+	1	729	c.729T>C	c.(727-729)tcT>tcC	p.S243S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CCTGTTCCTCTCACCTCATGG	0.493000													237	286					0	0	0.048971	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167592	140167592	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140167592A>C	ENST00000504120.2	+	1	1717	c.1717A>C	c.(1717-1719)Act>Cct	p.T573P	PCDHA1_ENST00000378133.3_Missense_Mutation_p.T573P|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGGGTGGCACTATTGGTGC	0.677000													37	56					0	0	0.042209	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086733	46086733	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:46086733C>G	ENST00000360770.3	-	1	111	c.71G>C	c.(70-72)tGt>tCt	p.C24S	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	24	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						GGGCACACAACAGGCTGGCTG	0.672000													36	34					0	0	0.048971	0	0
KLK8	11202	broad.mit.edu	37	19	51503811	51503811	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:51503811C>A	ENST00000600767.1	-	4	588	c.99G>T	c.(97-99)gtG>gtT	p.V33V	KLK8_ENST00000391806.2_Silent_p.V78V|KLK9_ENST00000250366.6_3'UTR|KLK8_ENST00000291726.7_Silent_p.V33V|KLK8_ENST00000320838.5_Intron|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000376832.4_3'UTR|KLK8_ENST00000593490.1_Intron|KLK8_ENST00000347619.4_Intron			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	33	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GACCCCCCAGCACCTTGTCCT	0.642000													4	88					0.014758	0.0150017	0.014758	1	0
TNNT2	7139	broad.mit.edu	37	1	201334414	201334414	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:201334414C>A	ENST00000509001.1	-	9	572	c.286G>T	c.(286-288)Gag>Tag	p.E96*	TNNT2_ENST00000421663.2_Nonsense_Mutation_p.E98*|TNNT2_ENST00000236918.7_Nonsense_Mutation_p.E101*|TNNT2_ENST00000360372.4_Nonsense_Mutation_p.E91*|TNNT2_ENST00000367322.1_Nonsense_Mutation_p.E96*|TNNT2_ENST00000458432.2_Nonsense_Mutation_p.E108*|TNNT2_ENST00000367317.4_Nonsense_Mutation_p.E96*|TNNT2_ENST00000367318.5_Nonsense_Mutation_p.E96*|TNNT2_ENST00000367315.2_Nonsense_Mutation_p.E96*|TNNT2_ENST00000367320.2_Intron	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	106					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						AGGTCCTTCTCCATGCGCTTC	0.577000													143	236					2.38067e-61	4.12203e-61	0.048971	1	0
NDUFS4	4724	broad.mit.edu	37	5	52942075	52942075	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:52942075T>G	ENST00000296684.5	+	3	218	c.190T>G	c.(190-192)Tta>Gta	p.L64V		NM_002495.2	NP_002486.1	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	64					brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(3)	10		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	TATCACTACTTTAACTGGAGT	0.348000													21	24					0	0	0.062417	0	0
ARAP3	64411	broad.mit.edu	37	5	141036183	141036183	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:141036183C>A	ENST00000239440.4	-	27	3742	c.3677G>T	c.(3676-3678)cGg>cTg	p.R1226L	ARAP3_ENST00000513878.1_Missense_Mutation_p.R888L|ARAP3_ENST00000508305.1_Missense_Mutation_p.R1057L|ARAP3_ENST00000512390.1_5'UTR	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1226	PH 3.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding	p.R1226L(1)		NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CAGCCCCACCCGTGGGCTCTC	0.642000													18	21					0.000229342	0.000239236	0.062417	1	0
NDRG4	65009	broad.mit.edu	37	16	58545443	58545443	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:58545443T>A	ENST00000394282.4	+	16	1546	c.1139T>A	c.(1138-1140)cTg>cAg	p.L380Q	NDRG4_ENST00000356752.4_Missense_Mutation_p.L358Q|NDRG4_ENST00000563799.1_Missense_Mutation_p.L346Q|NDRG4_ENST00000394279.2_Missense_Mutation_p.L360Q|NDRG4_ENST00000562999.1_Missense_Mutation_p.L316Q|NDRG4_ENST00000569923.1_Missense_Mutation_p.L273Q|NDRG4_ENST00000258187.5_Missense_Mutation_p.L360Q|NDRG4_ENST00000570248.1_Missense_Mutation_p.L341Q|NDRG4_ENST00000566192.1_Missense_Mutation_p.L328Q|NDRG4_ENST00000568640.1_Missense_Mutation_p.L346Q	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	341					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						AGCGAGGGGCTGGGCCAGGTC	0.682000													20	6					0	0	0.083992	0	0
TP53	7157	broad.mit.edu	37	17	7577532	7577532	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:7577532G>A	ENST00000420246.2	-	7	881	c.749C>T	c.(748-750)cCc>cTc	p.P250L	TP53_ENST00000445888.2_Missense_Mutation_p.P250L|TP53_ENST00000413465.2_Missense_Mutation_p.P250L|TP53_ENST00000359597.4_Missense_Mutation_p.P250L|TP53_ENST00000455263.2_Missense_Mutation_p.P250L|TP53_ENST00000269305.4_Missense_Mutation_p.P250L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	250	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		P -> A (in sporadic cancers; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P250L(45)|p.0?(8)|p.?(5)|p.P250H(4)|p.P250F(3)|p.P250N(2)|p.M246_P250delMNRRP(2)|p.P250_L252delPIL(2)|p.P250Q(2)|p.R248_P250delRRP(1)|p.P250_T253delPILT(1)|p.N247_P250delNRRP(1)|p.R249_P250delRP(1)|p.R249_T256delRPILTIIT(1)|p.I251fs*94(1)|p.R249_I251delRPI(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGAGGATGGGCCTCCGGTT	0.577000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			180	30					0	0	0.048971	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559374	129559374	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:129559374C>A	ENST00000422113.2	-	9	2672	c.2346G>T	c.(2344-2346)cgG>cgT	p.R782R	TMEM132D_ENST00000389441.4_Silent_p.R320R	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	782						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ACACACTCTTCCGCTTGGATT	0.488000													219	177					1.69577e-87	3.02912e-87	0.048971	1	0
MIR1208	100302281	broad.mit.edu	37	8	129162374	129162374	+	RNA	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:129162374C>G	ENST00000408334.1	+	0	13					NR_031613.1																						CCGGCAGAATCACTGTTCAGA	0.507000													45	70					0	0	0.048971	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492209	77492209	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:77492209C>G	ENST00000238647.3	-	1	2825	c.1927G>C	c.(1927-1929)Ggc>Cgc	p.G643R		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	643						nucleus		p.G643S(1)		endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						ACGGAACTGCCATCCTTGGGC	0.672000													10	12					0	0	0.069234	0	0
TDRD3	81550	broad.mit.edu	37	13	61083900	61083900	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:61083900G>A	ENST00000196169.3	+	9	1371	c.583G>A	c.(583-585)Gat>Aat	p.D195N	TDRD3_ENST00000535286.1_Missense_Mutation_p.D288N|TDRD3_ENST00000377881.2_Missense_Mutation_p.D195N|TDRD3_ENST00000377894.2_Missense_Mutation_p.D195N	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	195	UBA.				chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CTTCCAGGTTGATGAGAAAGC	0.403000													111	166					0	0	0.048971	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756524	94756524	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:94756524G>T	ENST00000554723.1	-	2	945	c.527C>A	c.(526-528)aCc>aAc	p.T176N	SERPINA10_ENST00000261994.4_Missense_Mutation_p.T136N|SERPINA10_ENST00000393096.1_Missense_Mutation_p.T136N|SERPINA10_ENST00000554173.1_Missense_Mutation_p.T136N			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	136					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		CCCGGGCTTGGTGGGCTTCAG	0.602000													59	104					6.75472e-32	9.89815e-32	0.048971	1	0
BIRC6	57448	broad.mit.edu	37	2	32724693	32724693	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:32724693G>A	ENST00000421745.2	+	46	8682	c.8548G>A	c.(8548-8550)Gtc>Atc	p.V2850I		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2850					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GAATTTTGAAGTCGTTTCAGT	0.443000													48	102					0	0	0.048971	0	0
CYP7B1	9420	broad.mit.edu	37	8	65528624	65528624	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:65528624C>G	ENST00000310193.3	-	3	647	c.474G>C	c.(472-474)atG>atC	p.M158I		NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	158					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TTAGATTCTGCATCATGCTTT	0.383000													63	56					0	0	0.048971	0	0
PID1	55022	broad.mit.edu	37	2	230020584	230020584	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:230020584G>C	ENST00000392054.3	-	3	559	c.220C>G	c.(220-222)Ctg>Gtg	p.L74V	PID1_ENST00000392055.3_Missense_Mutation_p.L43V|PID1_ENST00000354069.6_Missense_Mutation_p.L76V|PID1_ENST00000482518.2_5'UTR|PID1_ENST00000409462.1_Intron	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	76						cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GTCGTGCACAGCTCAATGGCC	0.522000													41	122					0	0	0.045515	0	0
MYO15A	51168	broad.mit.edu	37	17	18058425	18058425	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:18058425C>A	ENST00000205890.5	+	46	8564	c.8224_splice	c.e46-1	p.A2742_splice	MYO15A_ENST00000418233.3_Splice_Site_p.A6_splice|MYO15A_ENST00000585180.1_Splice_Site_p.A6_splice	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2742	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CTCCCATAGCCCAGAACCAGC	0.622000													6	4					8.12818e-05	8.50507e-05	0.029380	1	0
IL19	29949	broad.mit.edu	37	1	206972271	206972271	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:206972271C>G	ENST00000340758.2	+	1	57	c.32C>G	c.(31-33)tCt>tGt	p.S11C		NM_153758.2	NP_715639.1	Q9UHD0	IL19_HUMAN	interleukin 19	0					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			central_nervous_system(2)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7			BRCA - Breast invasive adenocarcinoma(75;0.211)			CCGCACAGATCTGCGTGTTCC	0.483000													32	35					0	0	0.045705	0	0
SOS1	6654	broad.mit.edu	37	2	39234202	39234202	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:39234202T>C	ENST00000426016.1	-	17	2729	c.2643A>G	c.(2641-2643)tcA>tcG	p.S881S	SOS1_ENST00000402219.2_Silent_p.S881S|SOS1_ENST00000395038.2_Silent_p.S881S			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	881	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				TGTAAACAGGTGATGAATTCA	0.338000									Noonan syndrome				6	298					0	0	0.029380	0	0
COL19A1	1310	broad.mit.edu	37	6	70850845	70850845	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:70850845G>T	ENST00000322773.4	+	20	1548		c.e20-1		COL19A1_ENST00000393344.1_Splice_Site	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1						cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CTTCTCCTTAGGGAGAGCCTT	0.373000													108	174					3.90656e-58	6.66182e-58	0.048971	1	0
TMOD1	7111	broad.mit.edu	37	9	100315641	100315641	+	Missense_Mutation	SNP	C	C	A	rs148848308		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:100315641C>A	ENST00000395211.2	+	4	492	c.356C>A	c.(355-357)gCc>gAc	p.A119D	TMOD1_ENST00000259365.3_Missense_Mutation_p.A119D	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	119	Tropomyosin-binding (Potential).				muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		CTGGAGGAAGCCTTGGCAAAT	0.537000													27	45					3.73148e-12	4.36306e-12	0.034045	1	0
FGD5	152273	broad.mit.edu	37	3	14939087	14939087	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:14939087G>C	ENST00000285046.5	+	5	2930	c.2820G>C	c.(2818-2820)gaG>gaC	p.E940D	FGD5_ENST00000543601.1_Missense_Mutation_p.E699D|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	940	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TGGCCCGGGAGGAGCTGAGGC	0.552000													7	8					0	0	0.038147	0	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127565	32127565	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:32127565G>T	ENST00000335093.3	-	1	181	c.132C>A	c.(130-132)tcC>tcA	p.S44S		NM_181619.1	NP_853650.1	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	44						intermediate filament		p.S44S(1)		breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7						agccataatgggagccaaacc	0.547000													53	112					1.41219e-46	2.2872e-46	0.048971	1	0
FSTL5	56884	broad.mit.edu	37	4	162508659	162508659	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:162508659G>T	ENST00000306100.5	-	8	1399	c.963C>A	c.(961-963)tgC>tgA	p.C321*	FSTL5_ENST00000511170.1_5'UTR|FSTL5_ENST00000427802.2_Nonsense_Mutation_p.C320*|FSTL5_ENST00000536695.1_Nonsense_Mutation_p.C320*|FSTL5_ENST00000379164.4_Nonsense_Mutation_p.C320*	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	321	Ig-like 1.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATCTGCATAGCAGGTGTAAT	0.363000													29	61					3.1745e-13	3.79706e-13	0.037714	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16838565	16838565	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:16838565C>A	ENST00000355661.3	-	11	1658	c.1648G>T	c.(1648-1650)Gac>Tac	p.D550Y	PLEKHA7_ENST00000531066.1_Missense_Mutation_p.D550Y|PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.D550Y			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	550	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						CGGCCCTGGTCGGTGAACTCT	0.677000													57	9					4.96213e-28	7.1173e-28	0.048971	1	0
RAPGEF4	11069	broad.mit.edu	37	2	173891808	173891808	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:173891808G>T	ENST00000264111.6	+	25	2563		c.e25-1		RAPGEF4_ENST00000409036.1_Splice_Site|RAPGEF4_ENST00000538974.1_Splice_Site|RAPGEF4_ENST00000397081.3_Splice_Site|RAPGEF4_ENST00000535187.1_Splice_Site|RAPGEF4_ENST00000540783.1_Splice_Site|RAPGEF4_ENST00000397087.3_Splice_Site|RAPGEF4_ENST00000539331.1_Splice_Site			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4						blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity	p.?(1)		breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTATTTTCTAGCTGGAGCTAA	0.328000													48	52					1.91693e-13	2.31743e-13	0.048971	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51628959	51628959	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:51628959C>T	ENST00000440804.3	+	2	594	c.527C>T	c.(526-528)cCt>cTt	p.P176L	SIGLEC9_ENST00000250360.3_Missense_Mutation_p.P176L	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	176	Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GGGACACCCCCTATGATCTCC	0.667000													136	135					0	0	0.048971	0	0
ARMC9	80210	broad.mit.edu	37	2	232072915	232072915	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:232072915T>A	ENST00000349938.4	+	3	321	c.127T>A	c.(127-129)Tgt>Agt	p.C43S	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	43							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		AAAACCATTGTGTAAAACAGT	0.303000													13	31					0	0	0.105934	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382213	41382213	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:41382213G>A	ENST00000377801.3	-	2	601	c.527C>T	c.(526-528)gCc>gTc	p.A176V	PLCXD3_ENST00000328457.3_Missense_Mutation_p.A176V			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	176	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AACTTCCTGGGCAAAAATCGC	0.448000													6	287					0	0	0.021553	0	0
FIBCD1	84929	broad.mit.edu	37	9	133780763	133780763	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:133780763G>T	ENST00000372338.4	-	6	1226	c.984C>A	c.(982-984)gcC>gcA	p.A328A	FIBCD1_ENST00000448616.1_Silent_p.A328A|FIBCD1_ENST00000372337.2_Silent_p.A170A|FIBCD1_ENST00000253018.4_Intron	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	328	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCAGCTCGTAGGCAGCCTGTG	0.622000													8	12					2.62144e-13	3.15786e-13	0.047766	1	0
DZIP3	9666	broad.mit.edu	37	3	108403123	108403123	+	Missense_Mutation	SNP	G	G	C	rs148202329		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:108403123G>C	ENST00000361582.3	+	27	3174	c.2944G>C	c.(2944-2946)Gtt>Ctt	p.V982L	DZIP3_ENST00000463306.1_Missense_Mutation_p.V982L	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	982					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CATACTTACTGTTCCTCAAAT	0.423000													231	350					0	0	0.048971	0	0
KCNT2	343450	broad.mit.edu	37	1	196285039	196285039	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:196285039G>T	ENST00000367433.5	-	20	2495	c.2394C>A	c.(2392-2394)aaC>aaA	p.N798K	KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.N822K|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.N748K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	822						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GTGTCTGCACGTTCACAATGG	0.448000													13	37					7.03913e-09	7.85089e-09	0.093190	1	0
LAMA5	3911	broad.mit.edu	37	20	60910172	60910172	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:60910172T>A	ENST00000252999.3	-	20	2453	c.2387A>T	c.(2386-2388)cAg>cTg	p.Q796L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	796	Laminin EGF-like 10.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGAAGCACTGGCCGGTGCC	0.642000													5	4					0	0	0.021553	0	0
MKRN3	7681	broad.mit.edu	37	15	23811302	23811302	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:23811302A>G	ENST00000314520.3	+	1	849	c.373A>G	c.(373-375)Aag>Gag	p.K125E	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	125						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTCTGGTCGGAAGATGGCCAC	0.602000													37	46					0	0	0.111260	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617113	111617113	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:111617113G>T	ENST00000374667.3	-	1	2126	c.1098C>A	c.(1096-1098)gaC>gaA	p.D366E		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	366						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CTGCAGGGCTGTCCCCGGGGC	0.662000													7	15					3.7963e-18	4.88612e-18	0.083992	1	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782408	27782408	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:27782408T>A	ENST00000333151.3	-	1	199	c.111A>T	c.(109-111)aaA>aaT	p.K37N		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	37					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						CATAGTTGCCTTTGCGGAGCA	0.672000													6	11					0	0	0.024245	0	0
HIF3A	64344	broad.mit.edu	37	19	46834463	46834463	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:46834463G>T	ENST00000339613.2	+	13	1850	c.1595G>T	c.(1594-1596)gGa>gTa	p.G532V	HIF3A_ENST00000377670.4_Missense_Mutation_p.G588V|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000420102.2_Missense_Mutation_p.G537V|HIF3A_ENST00000300862.3_Missense_Mutation_p.G586V|HIF3A_ENST00000244303.6_Missense_Mutation_p.G519V|HIF3A_ENST00000600383.1_Missense_Mutation_p.G519V|AC007193.10_ENST00000596807.1_RNA			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	588	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.G586E(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GAGCTGCTGGGAGTGAGACCT	0.572000													84	77					2.3666e-43	3.761e-43	0.048971	1	0
UTP20	27340	broad.mit.edu	37	12	101767525	101767525	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:101767525A>G	ENST00000261637.4	+	54	7285	c.7111A>G	c.(7111-7113)Act>Gct	p.T2371A		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2371					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TATGGTTACCACTTGGTTTGG	0.403000													37	86					0	0	0.080422	0	0
POLG	5428	broad.mit.edu	37	15	89870507	89870507	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:89870507C>A	ENST00000268124.5	-	7	1657	c.1324G>T	c.(1324-1326)Gag>Tag	p.E442*	POLG_ENST00000442287.2_Nonsense_Mutation_p.E442*	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	442					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AGGTAACGCTCCCAGTTCTGG	0.592000								DNA polymerases (catalytic subunits)					24	37					1.96895e-08	2.17097e-08	0.076483	1	0
CEP112	201134	broad.mit.edu	37	17	63746823	63746823	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:63746823T>A	ENST00000392769.2	-	22	2632	c.2414A>T	c.(2413-2415)cAg>cTg	p.Q805L	CEP112_ENST00000537949.1_Missense_Mutation_p.Q763L|CEP112_ENST00000580482.1_5'UTR|CEP112_ENST00000317442.8_Missense_Mutation_p.Q61L|CEP112_ENST00000535342.2_Missense_Mutation_p.Q805L|CEP112_ENST00000541355.1_Intron	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	805						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						CTTCTCAATCTGCTTCAGCTT	0.423000													113	263					0	0	0.048971	0	0
GLDC	2731	broad.mit.edu	37	9	6604786	6604786	+	Splice_Site	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:6604786T>C	ENST00000321612.6	-	7	1012		c.e7-2			NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)						glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGCCAGGCTCTAGAAAGGAAG	0.498000													80	109					0	0	0.048971	0	0
RASGRP1	10125	broad.mit.edu	37	15	38800056	38800056	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:38800056G>T	ENST00000310803.5	-	9	1290	c.1113C>A	c.(1111-1113)gaC>gaA	p.D371E	RASGRP1_ENST00000450598.2_Missense_Mutation_p.D371E|RASGRP1_ENST00000559830.1_Missense_Mutation_p.D371E|RASGRP1_ENST00000539159.1_Missense_Mutation_p.D323E|RASGRP1_ENST00000561180.1_Missense_Mutation_p.D422E|RASGRP1_ENST00000558164.1_Missense_Mutation_p.D371E	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	371	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		CCTCCAGATAGTCAGGCATGG	0.527000													19	18					3.5997e-14	4.37522e-14	0.069288	1	0
CXorf67	340602	broad.mit.edu	37	X	51150029	51150029	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:51150029C>T	ENST00000342995.2	+	1	263	c.161C>T	c.(160-162)cCc>cTc	p.P54L						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						CAAGCATCTCCCTCGGGCGGC	0.662000													11	9					0	0	0.033300	0	0
OR3A1	4994	broad.mit.edu	37	17	3195487	3195487	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:3195487G>T	ENST00000323404.1	-	1	389	c.390C>A	c.(388-390)tgC>tgA	p.C130*	RP11-64J4.2_ENST00000573491.1_RNA	NM_002550.2	NP_002541.2	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	20						TGAGGGGCCGGCAGATGGCCA	0.597000													150	20					1.09339e-60	1.88833e-60	0.048971	1	0
HSD17B4	3295	broad.mit.edu	37	5	118877683	118877683	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:118877683G>T	ENST00000504811.1	+	25	2464	c.2280G>T	c.(2278-2280)aaG>aaT	p.K760N	HSD17B4_ENST00000515320.1_Missense_Mutation_p.K717N|HSD17B4_ENST00000414835.2_Missense_Mutation_p.K595N|HSD17B4_ENST00000510025.1_Missense_Mutation_p.K711N|HSD17B4_ENST00000522415.1_3'UTR|HSD17B4_ENST00000509514.1_Missense_Mutation_p.K473N|HSD17B4_ENST00000256216.6_Missense_Mutation_p.K735N|HSD17B4_ENST00000513628.1_Missense_Mutation_p.K598N	NM_001199291.1	NP_001186220.1	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	735					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(2)	25		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	ACTACGCCAAGCTCTGAAGGG	0.413000													42	51					1.62957e-23	2.21976e-23	0.104719	1	0
FSTL5	56884	broad.mit.edu	37	4	162508658	162508658	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:162508658A>T	ENST00000306100.5	-	8	1400	c.964T>A	c.(964-966)Tat>Aat	p.Y322N	FSTL5_ENST00000511170.1_5'UTR|FSTL5_ENST00000427802.2_Missense_Mutation_p.Y321N|FSTL5_ENST00000536695.1_Missense_Mutation_p.Y321N|FSTL5_ENST00000379164.4_Missense_Mutation_p.Y321N	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	322	Ig-like 1.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCATCTGCATAGCAGGTGTAA	0.358000													28	60					0	0	0.030593	0	0
MYCBP2	23077	broad.mit.edu	37	13	77748446	77748446	+	Splice_Site	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:77748446C>T	ENST00000407578.2	-	37	5917	c.5651_splice	c.e37+1	p.R1884_splice	MYCBP2_ENST00000544440.2_Splice_Site_p.R1846_splice|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Splice_Site_p.R1846_splice	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1846					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATTCACCCACCTATAGTAGAG	0.413000													88	187					0	0	0.048971	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95513876	95513876	+	RNA	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:95513876T>A	ENST00000432432.2	-	0	735					NR_040113.1																						TGAGTCATAGTATACAGCAAG	0.348000													54	793					0	0	0.048971	0	0
ELTD1	64123	broad.mit.edu	37	1	79403639	79403639	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:79403639C>G	ENST00000370742.3	-	6	676	c.613G>C	c.(613-615)Gat>Cat	p.D205H		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	205					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ACAAATGTATCCCTTTGAACA	0.323000													72	96					0	0	0.048971	0	0
TENM2	57451	broad.mit.edu	37	5	167689762	167689762	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:167689762G>T	ENST00000519204.1	+	28	8027	c.7909G>T	c.(7909-7911)Gac>Tac	p.D2637Y	TENM2_ENST00000520394.1_Missense_Mutation_p.D2519Y|TENM2_ENST00000545108.1_Missense_Mutation_p.D2757Y|TENM2_ENST00000403607.2_Missense_Mutation_p.D2582Y|TENM2_ENST00000518659.1_Missense_Mutation_p.D2758Y					teneurin transmembrane protein 2																		AGAGCTTGCAGACAGTAGCAG	0.512000													11	7					2.27111e-07	2.46401e-07	0.093190	1	0
C16orf82	162083	broad.mit.edu	37	16	27078670	27078670	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:27078670G>T	ENST00000505035.1	+	0	643				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			TCAACACCCAGGCGGCCAGTA	0.647000													7	4					5.4927e-09	6.15656e-09	0.047766	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95662047	95662047	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:95662047T>C	ENST00000324972.6	+	12	1429	c.1236T>C	c.(1234-1236)gaT>gaC	p.D412D	DYNC1I1_ENST00000359388.4_Silent_p.D375D|DYNC1I1_ENST00000457059.1_Silent_p.D395D|DYNC1I1_ENST00000447467.2_Silent_p.D395D|DYNC1I1_ENST00000437599.1_Silent_p.D392D|DYNC1I1_ENST00000537881.1_Silent_p.D375D|DYNC1I1_ENST00000497626.1_3'UTR	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	412					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTCCACTGATGGCAAAATGT	0.448000													117	135					0	0	0.048971	0	0
TAS2R19	259294	broad.mit.edu	37	12	11175115	11175115	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:11175115A>G	ENST00000390673.2	-	1	104	c.56T>C	c.(55-57)cTt>cCt	p.L19P	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176888.1	NP_795369.1	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	19					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						AACATTTCCAAGAACAAATGC	0.393000													79	17					0	0	0.048971	0	0
RYR2	6262	broad.mit.edu	37	1	237656285	237656285	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:237656285G>T	ENST00000366574.2	+	19	2176	c.1859G>T	c.(1858-1860)tGc>tTc	p.C620F	RYR2_ENST00000542537.1_Missense_Mutation_p.C604F|RYR2_ENST00000360064.6_Missense_Mutation_p.C618F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	620	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCTGTGTTTGCCACGGGGTT	0.507000													7	13					2.0095e-06	2.14918e-06	0.029380	1	0
RBP2	5948	broad.mit.edu	37	3	139173624	139173624	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:139173624C>T	ENST00000232217.2	-	3	357	c.301G>A	c.(301-303)Gag>Aag	p.E101K	RP11-319G6.1_ENST00000515247.1_RNA	NM_004164.2	NP_004155.2	P50120	RET2_HUMAN	retinol binding protein 2, cellular	101					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			breast(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12					Vitamin A(DB00162)	TTCTCCTTCTCCCCCTTTTGC	0.522000													116	153					0	0	0.048971	0	0
COL4A4	1286	broad.mit.edu	37	2	228009238	228009238	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:228009238T>C	ENST00000396625.3	-	3	315	c.108A>G	c.(106-108)gtA>gtG	p.V36V	COL4A4_ENST00000329662.7_Silent_p.V36V	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	36					axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTACCCCATATACATATTGTA	0.308000													39	41					0	0	0.039052	0	0
FGL2	10875	broad.mit.edu	37	7	76828895	76828895	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:76828895G>A	ENST00000248598.5	-	1	248	c.216C>T	c.(214-216)ttC>ttT	p.F72F	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	72					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CGATCCTGCTGAATTGCTTCG	0.507000													151	184					0	0	0.048971	0	0
RELN	5649	broad.mit.edu	37	7	103276694	103276694	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:103276694C>A	ENST00000428762.1	-	18	2450	c.2291G>T	c.(2290-2292)aGc>aTc	p.S764I	RELN_ENST00000343529.5_Missense_Mutation_p.S764I|RELN_ENST00000424685.2_Missense_Mutation_p.S764I	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	764					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGATTGTGAGCTGTCAAGGAA	0.408000													13	27					2.31682e-05	2.43554e-05	0.024245	1	0
SNRPG	6637	broad.mit.edu	37	2	70508813	70508813	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:70508813T>C	ENST00000482975.2	-	4	915	c.148A>G	c.(148-150)Ata>Gta	p.I50V	SNRPG_ENST00000272348.2_Missense_Mutation_p.I62V|SNRPG_ENST00000454893.1_Silent_p.*97*|SNRPG_ENST00000429728.1_5'UTR|SNRPG_ENST00000449935.2_Missense_Mutation_p.I50V|SNRPG_ENST00000438261.1_Missense_Mutation_p.I50V|SNRPG_ENST00000413456.2_Missense_Mutation_p.I54V			P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	62					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			endometrium(1)	1						TTTCCTCGTATTACCTAAGAA	0.333000													39	67					0	0	0.104719	0	0
LOC442028	442028	broad.mit.edu	37	2	95558407	95558407	+	RNA	SNP	A	A	G	rs5006801		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:95558407A>G	ENST00000568768.1	-	0	476																											CTCAAAACAGAATGCATCTGG	0.463000													3	20					0	0	0.004672	0	0
SUN3	256979	broad.mit.edu	37	7	48046777	48046777	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:48046777G>A	ENST00000453192.2	-	6	684	c.441C>T	c.(439-441)gaC>gaT	p.D147D	SUN3_ENST00000412142.1_Silent_p.D59D|SUN3_ENST00000297325.4_Silent_p.D159D|SUN3_ENST00000395572.2_Silent_p.D159D			Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	159						integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGTGGTCCGGGTCCTCCACAG	0.542000													45	69					0	0	0.042209	0	0
UNC5C	8633	broad.mit.edu	37	4	96222767	96222767	+	Silent	SNP	C	C	T	rs139673541	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:96222767C>T	ENST00000453304.1	-	3	828	c.480G>A	c.(478-480)gtG>gtA	p.V160V	UNC5C_ENST00000506749.1_Silent_p.V160V|UNC5C_ENST00000504962.1_Silent_p.V160V	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	160					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		ATGCAATGCGCACATACGCCT	0.502000													44	118					0	0	0.048971	0	0
NLRP13	126204	broad.mit.edu	37	19	56423995	56423995	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:56423995C>A	ENST00000588751.1	-	5	1212	c.1188G>T	c.(1186-1188)atG>atT	p.M396I	NLRP13_ENST00000342929.3_Missense_Mutation_p.M396I			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	396	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAAAGTGTCTCATGAAATATA	0.438000													119	95					6.1095e-40	9.57438e-40	0.048971	1	0
OR2B11	127623	broad.mit.edu	37	1	247615073	247615073	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:247615073G>T	ENST00000318749.6	-	1	235	c.212C>A	c.(211-213)tCc>tAc	p.S71Y		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTCCAGGAAGGACAGGTGACT	0.567000													162	227					4.5173e-83	8.04792e-83	0.048971	1	0
ARHGEF2	9181	broad.mit.edu	37	1	155935171	155935171	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:155935171C>A	ENST00000368316.1	-	10	892	c.422G>T	c.(421-423)cGc>cTc	p.R141L	ARHGEF2_ENST00000368315.3_Missense_Mutation_p.R169L|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.R141L|ARHGEF2_ENST00000361247.4_Missense_Mutation_p.R168L|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.R168L			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	168					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAGGATCCGGCGCAGCCCCAG	0.587000													45	98					1.03325e-14	1.26722e-14	0.042209	1	0
TMCC1	23023	broad.mit.edu	37	3	129389291	129389291	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:129389291C>A	ENST00000393238.3	-	4	1733	c.1393G>T	c.(1393-1395)Gag>Tag	p.E465*	TMCC1_ENST00000329333.5_Nonsense_Mutation_p.E286*|TMCC1_ENST00000432054.2_Nonsense_Mutation_p.E141*|TMCC1_ENST00000426664.2_Nonsense_Mutation_p.E351*	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	465						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						TCCTGGATCTCATGTAGTAGT	0.502000													78	84					9.59377e-39	1.4931e-38	0.048971	1	0
CSMD2	114784	broad.mit.edu	37	1	34238314	34238314	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:34238314C>G	ENST00000373381.4	-	13	1878	c.1702G>C	c.(1702-1704)Gca>Cca	p.A568P	CSMD2_ENST00000338325.1_Missense_Mutation_p.A176P	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	528	Sushi 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGGCCATATGCAGGTATGCCA	0.532000													5	110					0	0	0.014758	0	0
CPZ	8532	broad.mit.edu	37	4	8621242	8621242	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:8621242C>T	ENST00000429646.2	+	9	3474	c.681C>T	c.(679-681)ctC>ctT	p.L227L	CPZ_ENST00000315782.6_Silent_p.L608L|CPZ_ENST00000382480.2_Silent_p.L482L|CPZ_ENST00000360986.4_Silent_p.L619L			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	619					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CCGACCCGCTCCGGGCGCGCA	0.667000													25	44					0	0	0.054565	0	0
SOX13	9580	broad.mit.edu	37	1	204082127	204082127	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:204082127G>T	ENST00000367204.1	+	2	193	c.84G>T	c.(82-84)gaG>gaT	p.E28D	SOX13_ENST00000367203.4_3'UTR	NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	28					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			AGTCAGAGGAGAAGAAAGAGC	0.647000													10	8					2.74318e-10	3.14768e-10	0.058154	1	0
TTC12	54970	broad.mit.edu	37	11	113194102	113194102	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:113194102G>A	ENST00000393020.1	+	3	556	c.151G>A	c.(151-153)Gac>Aac	p.D51N	TTC12_ENST00000314756.3_Missense_Mutation_p.D51N|TTC12_ENST00000483239.2_Missense_Mutation_p.D51N|TTC12_ENST00000529221.1_Missense_Mutation_p.D51N			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	51							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TATGGAGGAAGACCAGGAGGA	0.413000													149	169					0	0	0.048971	0	0
GPX7	2882	broad.mit.edu	37	1	53072521	53072521	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:53072521A>T	ENST00000361314.4	+	2	342	c.304A>T	c.(304-306)Agc>Tgc	p.S102C	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	102					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	GGAGATTGAGAGCTTTGCCCG	0.577000													101	157					0	0	0.048971	0	0
TREML4	285852	broad.mit.edu	37	6	41197840	41197840	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:41197840C>A	ENST00000341495.2	+	4	590	c.486C>A	c.(484-486)tcC>tcA	p.S162S	TREML4_ENST00000448827.2_Silent_p.S162S	NM_198153.2	NP_937796.1	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid cells-like 4	162						extracellular region				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.196)					GCCATCCCTCCATCAATGGCT	0.527000													53	102					5.44684e-13	6.4921e-13	0.048971	1	0
COL4A4	1286	broad.mit.edu	37	2	227973939	227973939	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:227973939C>A	ENST00000396625.3	-	10	865		c.e10+1		COL4A4_ENST00000329662.7_Splice_Site	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4						axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCTGTACTTACCACTAACCCT	0.468000													61	150					2.14255e-21	2.85533e-21	0.048971	1	0
TRRAP	8295	broad.mit.edu	37	7	98557026	98557026	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:98557026G>T	ENST00000359863.4	+	44	6590	c.6381G>T	c.(6379-6381)gtG>gtT	p.V2127V	TRRAP_ENST00000355540.3_Silent_p.V2109V|TRRAP_ENST00000446306.3_Silent_p.V2108V	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2127	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCCGGTGTGTGAACCTTCTGA	0.562000													14	117					4.93089e-13	5.8875e-13	0.020292	1	0
BLK	640	broad.mit.edu	37	8	11400849	11400849	+	Missense_Mutation	SNP	C	C	A	rs142352008	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:11400849C>A	ENST00000259089.4	+	2	708	c.116C>A	c.(115-117)cCg>cAg	p.P39Q	BLK_ENST00000529894.1_Intron	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	39					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CCGCCACTGCCGCCCCTGGTG	0.532000													14	10					5.90632e-09	6.60922e-09	0.050027	1	0
TMEM30A	55754	broad.mit.edu	37	6	75968498	75968498	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:75968498T>C	ENST00000230461.6	-	6	1219	c.890A>G	c.(889-891)tAc>tGc	p.Y297C	TMEM30A_ENST00000370050.5_Missense_Mutation_p.Y178C|TMEM30A_ENST00000475111.2_Missense_Mutation_p.Y261C	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	297						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AAGGATACTGTATGTGACATT	0.393000													30	32					0	0	0.092188	0	0
RAB5C	5878	broad.mit.edu	37	17	40278776	40278776	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:40278776T>G	ENST00000393860.3	-	6	848	c.532A>C	c.(532-534)Ata>Cta	p.I178L	CTD-2132N18.3_ENST00000592574.1_Intron|RAB5C_ENST00000346213.4_Missense_Mutation_p.I178L|RAB5C_ENST00000547517.1_Missense_Mutation_p.I211L	NM_201434.2	NP_958842.1	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family	178					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|lung(4)|prostate(1)|skin(1)	7		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		AACTGACCTATTGCCATGAAG	0.522000													143	247					0	0	0.048971	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798332	185798332	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:185798332G>T	ENST00000302277.6	+	3	852	c.258G>T	c.(256-258)agG>agT	p.R86S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	86						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTTAACAGAGGCTCAAGGAAC	0.338000													28	78					8.16721e-17	1.03543e-16	0.045705	1	0
AHNAK2	113146	broad.mit.edu	37	14	105416009	105416009	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:105416009C>A	ENST00000333244.5	-	7	5898	c.5779G>T	c.(5779-5781)Gat>Tat	p.D1927Y	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1927						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCTTAACATCTGTCTGGGGG	0.627000													33	59					3.28013e-08	3.60495e-08	0.074837	1	0
LVRN	206338	broad.mit.edu	37	5	115298845	115298845	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:115298845C>T	ENST00000357872.4	+	1	655	c.531C>T	c.(529-531)gaC>gaT	p.D177D	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		177					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										TGCCCGTGGACGACGTGTGGT	0.657000													4	43					0	0	0.014758	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137089259	137089259	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:137089259T>A	ENST00000314940.4	-	1	780	c.497A>T	c.(496-498)cAt>cTt	p.H166L		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	166	RRM 2.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCCACGCGATGGCCCTGAAT	0.642000													22	17					0	0	0.062417	0	0
FAIM2	23017	broad.mit.edu	37	12	50294975	50294975	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:50294975C>A	ENST00000320634.3	-	2	243	c.149G>T	c.(148-150)gGg>gTg	p.G50V	FAIM2_ENST00000550890.1_Missense_Mutation_p.G4V	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	50					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						GGGGAAGGCCCCTGCCTTCAT	0.642000													21	25					1.62565e-12	1.9107e-12	0.050027	1	0
PHOX2A	401	broad.mit.edu	37	11	71952279	71952279	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:71952279C>G	ENST00000298231.5	-	2	443	c.272G>C	c.(271-273)cGg>cCg	p.R91P	PHOX2A_ENST00000544057.1_5'UTR	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	91					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						GCGGATGCGCCGCTGCTTGCG	0.657000													19	41					0	0	0.083992	0	0
MPZL1	9019	broad.mit.edu	37	1	167741611	167741611	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:167741611A>G	ENST00000359523.2	+	3	560	c.358A>G	c.(358-360)Atc>Gtc	p.I120V	MPZL1_ENST00000474859.1_Missense_Mutation_p.I120V|MPZL1_ENST00000392121.3_Intron	NM_003953.5|NM_024569.4	NP_003944.1|NP_078845.3	O95297	MPZL1_HUMAN	myelin protein zero-like 1	120	Ig-like V-type.				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity	p.I120L(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(2)	15	all_hematologic(923;0.215)					AGATGCATCAATCAACATAGA	0.428000													108	129					0	0	0.048971	0	0
MTSS1L	92154	broad.mit.edu	37	16	70698083	70698083	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:70698083C>T	ENST00000338779.6	-	15	2015	c.1741G>A	c.(1741-1743)Gct>Act	p.A581T	FLJ00418_ENST00000597002.1_5'UTR	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	581					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						ATGGGGCCAGCGCTGGACAGG	0.756000													15	15					0	0	0.033300	0	0
EXOC4	60412	broad.mit.edu	37	7	132990804	132990804	+	Silent	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:132990804A>G	ENST00000253861.4	+	4	674	c.645A>G	c.(643-645)aaA>aaG	p.K215K	EXOC4_ENST00000539845.1_Silent_p.K114K|EXOC4_ENST00000393161.2_Silent_p.K215K	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	215					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				ACAAGGAAAAAGGGAAAATCA	0.403000													3	179					0	0	0.014758	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228515	142228515	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:142228515C>A	ENST00000519067.1	-	4	1374	c.1071G>T	c.(1069-1071)acG>acT	p.T357T	SLC45A4_ENST00000433583.2_Silent_p.T350T|SLC45A4_ENST00000024061.3_Silent_p.T357T|SLC45A4_ENST00000517878.1_Silent_p.T408T			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	408					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGGAGCTCGACGTGGCCGAGG	0.632000													6	14					0.00316338	0.00324486	0.024245	1	0
TPO	7173	broad.mit.edu	37	2	1481057	1481057	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:1481057T>G	ENST00000345913.4	+	8	1110	c.1019T>G	c.(1018-1020)cTg>cGg	p.L340R	TPO_ENST00000382201.3_Missense_Mutation_p.L340R|TPO_ENST00000382198.1_Intron|TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.L340R|TPO_ENST00000337415.3_Missense_Mutation_p.L340R|TPO_ENST00000329066.4_Missense_Mutation_p.L340R	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	340					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GAGAGGCAGCTGCGGAACTGG	0.711000													7	5					0	0	0.038147	0	0
DPP3	10072	broad.mit.edu	37	11	66249733	66249733	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:66249733A>T	ENST00000532677.1	+	2	520	c.119A>T	c.(118-120)gAg>gTg	p.E40V	DPP3_ENST00000531863.1_Missense_Mutation_p.E41V|DPP3_ENST00000360510.2_Missense_Mutation_p.E21V|DPP3_ENST00000453114.1_Missense_Mutation_p.E21V|DPP3_ENST00000530165.1_Missense_Mutation_p.E21V|DPP3_ENST00000541961.1_Missense_Mutation_p.E21V	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	21					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						GACTGCCGTGAGGCCTTCCGC	0.627000													4	67					0	0	0.009096	0	0
HOXA5	3202	broad.mit.edu	37	7	27183196	27183196	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:27183196C>A	ENST00000222726.3	-	1	91	c.31G>T	c.(31-33)Ggt>Tgt	p.G11C	HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	11					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						GGATAGCGACCGCAAAATGAG	0.473000													86	92					6.09681e-45	9.73476e-45	0.048971	1	0
CDC20B	166979	broad.mit.edu	37	5	54420672	54420672	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:54420672C>A	ENST00000296733.1	-	9	1348	c.1174G>T	c.(1174-1176)Ggc>Tgc	p.G392C	CDC20B_ENST00000381375.2_Missense_Mutation_p.G392C|CDC20B_ENST00000322374.6_Missense_Mutation_p.G392C|CDC20B_ENST00000334206.5_3'UTR	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	392										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			AGCGGTTGGCCCTGTGCACTG	0.542000													40	41					2.3623e-07	2.55884e-07	0.039052	1	0
HIST1H4K	8362	broad.mit.edu	37	6	27798951	27798951	+	Splice_Site	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:27798951G>C	ENST00000357549.2	-	1	354		c.e1+1			NM_003541.2	NP_003532.1	P62805	H4_HUMAN	histone cluster 1, H4k						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(1)|endometrium(1)|lung(3)|ovary(1)|prostate(1)	7						AGCTGAGAAAGTGGGGGCCCT	0.552000													14	15					0	0	0.020292	0	0
SPEG	10290	broad.mit.edu	37	2	220342497	220342497	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:220342497G>T	ENST00000312358.7	+	21	4948	c.4816G>T	c.(4816-4818)Gag>Tag	p.E1606*	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1606	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CATCCACCAGGAGATCGGCAG	0.627000													31	18					3.54909e-21	4.71124e-21	0.042209	1	0
HCRT	3060	broad.mit.edu	37	17	40336456	40336456	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:40336456C>T	ENST00000293330.1	-	2	198	c.112G>A	c.(112-114)Gac>Aac	p.D38N		NM_001524.1	NP_001515.1	O43612	OREX_HUMAN	hypocretin (orexin) neuropeptide precursor	38					neuropeptide signaling pathway	cell junction|extracellular region|rough endoplasmic reticulum|synaptic vesicle				breast(1)|central_nervous_system(1)	2		all_cancers(22;1.39e-06)|all_epithelial(22;9.98e-06)|Breast(137;0.000143)|Ovarian(249;0.0221)|Myeloproliferative disorder(1115;0.0255)|Colorectal(1115;0.069)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CGACAGCAGTCGGGCAGGGGC	0.692000													9	9					0	0	0.058154	0	0
CALR3	125972	broad.mit.edu	37	19	16593367	16593367	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:16593367T>A	ENST00000269881.3	-	7	874	c.812A>T	c.(811-813)cAt>cTt	p.H271L	CTD-3222D19.2_ENST00000409035.1_3'UTR|CALR3_ENST00000602234.1_5'UTR	NM_145046.4	NP_659483.2	Q96L12	CALR3_HUMAN	calreticulin 3	271	3 X approximate repeats.|P-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|prostate(1)|skin(1)	15						GACGTCTTTATGAATACCTTC	0.502000													59	80					0	0	0.048971	0	0
VCAN	1462	broad.mit.edu	37	5	82875805	82875805	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:82875805G>A	ENST00000265077.3	+	14	10452	c.9887G>A	c.(9886-9888)tGc>tAc	p.C3296Y	VCAN_ENST00000343200.5_Missense_Mutation_p.C2309Y|VCAN_ENST00000502527.2_Missense_Mutation_p.C555Y|VCAN_ENST00000512590.2_Missense_Mutation_p.C1494Y|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000342785.4_Missense_Mutation_p.C1542Y|VCAN_ENST00000513016.1_3'UTR	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3296	Sushi.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTAGTCGCTTGCGGCCAGCCC	0.378000													112	128					0	0	0.048971	0	0
MAGEB18	286514	broad.mit.edu	37	X	26158064	26158064	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:26158064G>T	ENST00000325250.1	+	2	1149	c.962G>T	c.(961-963)aGg>aTg	p.R321M		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	321							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						GCTGCAGCCAGGGCTCATACT	0.512000													16	3					1.67942e-08	1.85475e-08	0.038395	1	0
PARN	5073	broad.mit.edu	37	16	14693769	14693769	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:14693769C>A	ENST00000437198.2	-	12	973	c.832G>T	c.(832-834)Gct>Tct	p.A278S	PARN_ENST00000420015.2_Missense_Mutation_p.A232S|PARN_ENST00000539279.1_Missense_Mutation_p.A103S|PARN_ENST00000341484.7_Missense_Mutation_p.A217S	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	278					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						ACCGAATTAGCAATGGCGTGA	0.318000													63	16					5.02053e-37	7.68982e-37	0.048971	1	0
CTNNA1	1495	broad.mit.edu	37	5	138260225	138260225	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:138260225A>T	ENST00000302763.7	+	12	1663	c.1573A>T	c.(1573-1575)Aaa>Taa	p.K525*	CTNNA1_ENST00000518825.1_Nonsense_Mutation_p.K525*|CTNNA1_ENST00000355078.5_Nonsense_Mutation_p.K422*|CTNNA1_ENST00000540387.1_Nonsense_Mutation_p.K155*	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	525					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGATGTGAACAAATGTGTCAT	0.493000													56	101					0	0	0.048971	0	0
SLC25A28	81894	broad.mit.edu	37	10	101370759	101370759	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:101370759C>A	ENST00000370495.4	-	4	970	c.942G>T	c.(940-942)acG>acT	p.T314T	SLC25A28_ENST00000496035.1_5'UTR	NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	314					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		CTTGATATACCGTCCTGAAGG	0.517000													46	83					3.05275e-18	3.93659e-18	0.045515	1	0
CCDC80	151887	broad.mit.edu	37	3	112324420	112324420	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:112324420C>A	ENST00000206423.3	-	8	3650	c.2697G>T	c.(2695-2697)cgG>cgT	p.R899R	CCDC80_ENST00000439685.2_Silent_p.R899R	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	899										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						TTTCCTGTCTCCGAAGTTGCA	0.473000													55	69					7.89702e-26	1.0978e-25	0.048971	1	0
PML	5371	broad.mit.edu	37	15	74337262	74337262	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:74337262G>C	ENST00000565898.1	+	8	2502	c.2418G>C	c.(2416-2418)ttG>ttC	p.L806F	PML_ENST00000268058.3_Missense_Mutation_p.L854F			P29590	PML_HUMAN	promyelocytic leukemia	854					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						AAGGCCTGTTGGAGGGTCCGG	0.637000			T	"""RARA, PAX5"""	"""APL, ALL"""								64	91					0	0	0.048971	0	0
TRPC4	7223	broad.mit.edu	37	13	38320545	38320545	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:38320545G>A	ENST00000379705.3	-	3	1283	c.426C>T	c.(424-426)gaC>gaT	p.D142D	TRPC4_ENST00000426868.2_Silent_p.D142D|TRPC4_ENST00000379679.1_Intron|TRPC4_ENST00000379681.3_Silent_p.D142D|TRPC4_ENST00000379673.2_Silent_p.D142D|TRPC4_ENST00000447043.1_Silent_p.D142D|TRPC4_ENST00000338947.5_Intron|TRPC4_ENST00000355779.2_Silent_p.D142D|TRPC4_ENST00000358477.2_Silent_p.D142D			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	142	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTGGTGTAATGTCTGGAGTGA	0.398000													161	52					0	0	0.048971	0	0
MAP3K3	4215	broad.mit.edu	37	17	61768535	61768535	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:61768535G>T	ENST00000361357.3	+	14	1697	c.1379G>T	c.(1378-1380)gGc>gTc	p.G460V	MAP3K3_ENST00000361733.3_Missense_Mutation_p.G429V|MAP3K3_ENST00000579585.1_Missense_Mutation_p.G460V|MAP3K3_ENST00000584573.1_Missense_Mutation_p.G456V|MAP3K3_ENST00000577395.1_Missense_Mutation_p.G425V	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	429	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						CAGTACTATGGCTGTCTGCGG	0.562000													42	45					2.20914e-33	3.2798e-33	0.042209	1	0
NCAM2	4685	broad.mit.edu	37	21	22658668	22658668	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:22658668C>A	ENST00000400546.1	+	4	666	c.417C>A	c.(415-417)agC>agA	p.S139R	NCAM2_ENST00000284894.7_Intron|NCAM2_ENST00000535285.1_Missense_Mutation_p.S164R|NCAM2_ENST00000486367.1_3'UTR	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	139	Ig-like C2-type 2.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GCCGAGTTAGCAGTTCACCTG	0.398000													59	76					2.01871e-26	2.82954e-26	0.048971	1	0
WDR11	55717	broad.mit.edu	37	10	122643308	122643308	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:122643308G>T	ENST00000263461.6	+	14	2002	c.1756G>T	c.(1756-1758)Gta>Tta	p.V586L	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	586						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TTTGGCAGTCGTATTCAGAGA	0.348000													68	78					6.72169e-28	9.60039e-28	0.048971	1	0
ZNF232	7775	broad.mit.edu	37	17	5012586	5012586	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:5012586C>A	ENST00000416429.2	-	3	798	c.520G>T	c.(520-522)Ggc>Tgc	p.G174C	ZNF232_ENST00000575898.1_Intron|ZNF232_ENST00000250076.3_Intron|ZNF232_ENST00000575538.1_Intron			Q9UNY5	ZN232_HUMAN	zinc finger protein 232	0					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						TCTACCTGGCCCAAGAGAGGT	0.532000													31	4					1.75199e-13	2.12181e-13	0.034045	1	0
SGCD	6444	broad.mit.edu	37	5	156186253	156186253	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:156186253G>T	ENST00000435422.3	+	8	1209	c.722G>T	c.(721-723)aGg>aTg	p.R241M	SGCD_ENST00000337851.4_Missense_Mutation_p.R242M	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	241					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCGAAAATCAGGCTACCTAGA	0.478000													66	102					4.66136e-34	6.95098e-34	0.048971	1	0
CLIP2	7461	broad.mit.edu	37	7	73768239	73768239	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:73768239G>T	ENST00000223398.6	+	4	1035	c.708G>T	c.(706-708)cgG>cgT	p.R236R	CLIP2_ENST00000395060.1_Silent_p.R236R|CLIP2_ENST00000361545.5_Silent_p.R236R	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	236						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GCGTGGTGCGGTACGTGGGGG	0.647000													159	289					1.63722e-96	2.94006e-96	0.048971	1	0
OR56B4	196335	broad.mit.edu	37	11	6129756	6129756	+	Missense_Mutation	SNP	C	C	T	rs58431577	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:6129756C>T	ENST00000316529.3	+	1	843	c.748C>T	c.(748-750)Cac>Tac	p.H250Y	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGTAGCTCCCACCTCATCCT	0.468000													121	26					0	0	0.048971	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798221	140798221	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140798221G>T	ENST00000398594.2	+	1	795	c.795G>T	c.(793-795)aaG>aaT	p.K265N	PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGAGTGAAGGCCACTGACC	0.527000													25	43					1.1804e-14	1.43987e-14	0.091800	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118236276	118236276	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:118236276C>A	ENST00000369230.3	+	11	1431	c.1285C>A	c.(1285-1287)Cag>Aag	p.Q429K		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	429	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		TGAAGATTCTCAGAATAAGTT	0.323000													156	191					2.77756e-48	4.53111e-48	0.048971	1	0
FHL5	9457	broad.mit.edu	37	6	97053948	97053948	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:97053948G>T	ENST00000326771.2	+	5	884		c.e5+1		FHL5_ENST00000541107.1_Splice_Site	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5							nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TTGTAAGAAGGTAATTTTCTA	0.348000													37	59					2.40579e-17	3.07306e-17	0.086207	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701605	56701605	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:56701605C>A	ENST00000586855.2	-	5	1392	c.1079G>T	c.(1078-1080)tGc>tTc	p.C360F	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.C360F			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	360					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TGATTTATTGCACACGTCACA	0.532000													122	143					1.38063e-58	2.36032e-58	0.048971	1	0
SLC25A23	79085	broad.mit.edu	37	19	6454458	6454458	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:6454458T>C	ENST00000301454.4	-	6	777	c.671A>G	c.(670-672)aAc>aGc	p.N224S	SLC25A23_ENST00000334510.5_Missense_Mutation_p.N224S|SLC25A23_ENST00000414491.2_Missense_Mutation_p.N41S	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	224					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						CCCAAGGATGTTCAGCCGGTT	0.602000													68	77					0	0	0.048971	0	0
JAK3	3718	broad.mit.edu	37	19	17945771	17945771	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:17945771G>T	ENST00000458235.1	-	16	2188	c.2089C>A	c.(2089-2091)Cgg>Agg	p.R697R	JAK3_ENST00000534444.1_Silent_p.R697R|JAK3_ENST00000527670.1_Silent_p.R697R	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	697	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						TGCGCCTCCCGGAGACACTCG	0.622000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								110	128					1.40631e-78	2.49234e-78	0.048971	1	0
SEZ6L	23544	broad.mit.edu	37	22	26688759	26688759	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:26688759C>A	ENST00000529632.2	+	2	678	c.482C>A	c.(481-483)aCg>aAg	p.T161K	SEZ6L_ENST00000360929.3_Missense_Mutation_p.T161K|SEZ6L_ENST00000404234.3_Missense_Mutation_p.T161K|SEZ6L_ENST00000248933.6_Missense_Mutation_p.T161K|SEZ6L_ENST00000343706.4_Missense_Mutation_p.T161K|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000402979.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	161						endoplasmic reticulum membrane|integral to membrane		p.T161K(1)|p.T161M(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TCCTCCTCCACGGAGAAGCCT	0.677000													152	24					6.31826e-54	1.06404e-53	0.048971	1	0
RSPH6A	81492	broad.mit.edu	37	19	46318261	46318261	+	Silent	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:46318261T>A	ENST00000221538.3	-	1	316	c.174A>T	c.(172-174)tcA>tcT	p.S58S	RSPH6A_ENST00000597055.1_Silent_p.S58S	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	58						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						TGCCCCTCTGTGACCAACCAG	0.642000													25	30					0	0	0.041601	0	0
GPR158	57512	broad.mit.edu	37	10	25887861	25887861	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:25887861G>T	ENST00000376351.3	+	11	3665	c.3306G>T	c.(3304-3306)gaG>gaT	p.E1102D	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1102						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CAAAAGAGGAGAACGGAGGTC	0.502000													68	112					1.931e-44	3.07596e-44	0.048971	1	0
VCAN	1462	broad.mit.edu	37	5	82834200	82834200	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:82834200T>C	ENST00000265077.3	+	8	5943	c.5378T>C	c.(5377-5379)tTt>tCt	p.F1793S	VCAN_ENST00000343200.5_Missense_Mutation_p.F806S|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1793	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACTCCTGTCTTTACAGAAACA	0.443000													78	116					0	0	0.048971	0	0
OASL	8638	broad.mit.edu	37	12	121469379	121469379	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:121469379C>A	ENST00000257570.5	-	3	793	c.523G>T	c.(523-525)Gtg>Ttg	p.V175L	OASL_ENST00000339275.5_Missense_Mutation_p.V175L	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	175					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATCAGGCTCACATAGACCTCA	0.542000													99	94					3.89013e-33	5.75026e-33	0.048971	1	0
ABCC9	10060	broad.mit.edu	37	12	22065815	22065815	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:22065815G>T	ENST00000261200.4	-	6	1001	c.1002C>A	c.(1000-1002)aaC>aaA	p.N334K	ABCC9_ENST00000261201.4_Missense_Mutation_p.N334K|ABCC9_ENST00000345162.2_Missense_Mutation_p.N334K	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	334	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTCCAGTTGTGTTATTTGTCC	0.368000													63	10					5.10508e-28	7.30685e-28	0.048971	1	0
TLN2	83660	broad.mit.edu	37	15	62989969	62989969	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:62989969G>T	ENST00000561311.1	+	14	1605	c.1375G>T	c.(1375-1377)Ggc>Tgc	p.G459C	TLN2_ENST00000306829.6_Missense_Mutation_p.G459C			Q9Y4G6	TLN2_HUMAN	talin 2	459					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GATGCGCTCGGGCTCCAGCGG	0.652000													38	61					1.836e-18	2.37662e-18	0.064281	1	0
CCDC59	29080	broad.mit.edu	37	12	82750917	82750917	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:82750917G>A	ENST00000256151.7	-	2	697	c.286C>T	c.(286-288)Ctc>Ttc	p.L96F	CCDC59_ENST00000548126.1_5'UTR	NM_014167.4	NP_054886.2	Q9P031	TAP26_HUMAN	coiled-coil domain containing 59	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)	5						GCTAAATAGAGATGTTTCAGA	0.408000													64	78					0	0	0.048971	0	0
WTAPP1	100288077	broad.mit.edu	37	11	102702721	102702721	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:102702721G>T	ENST00000525739.2	+	0	1284					NR_038390.1																						AACAATGGTAGACCGAGCCAT	0.507000													6	3					2.0095e-06	2.14918e-06	0.029380	1	0
CALCOCO1	57658	broad.mit.edu	37	12	54105846	54105846	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:54105846C>A	ENST00000262059.4	-	15	2320	c.1955G>T	c.(1954-1956)tGg>tTg	p.W652L	CALCOCO1_ENST00000548263.1_3'UTR|CALCOCO1_ENST00000550804.1_Missense_Mutation_p.W653L|CALCOCO1_ENST00000430117.2_Missense_Mutation_p.W568L	NM_020898.2	NP_065949.1	Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	653	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						ACACTCCTTCCATGTGGGGGT	0.572000													45	47					8.48111e-28	1.20624e-27	0.048971	1	0
KCTD3	51133	broad.mit.edu	37	1	215793472	215793472	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:215793472C>T	ENST00000259154.4	+	18	2254	c.1960C>T	c.(1960-1962)Cct>Tct	p.P654S	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	654						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CAGAGAAAGTCCTTTATTAGC	0.413000													44	60					0	0	0.039052	0	0
LGALS9C	654346	broad.mit.edu	37	17	18392259	18392259	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:18392259C>A	ENST00000328114.6	+	5	530	c.449C>A	c.(448-450)cCc>cAc	p.P150H	LGALS9C_ENST00000412421.2_Missense_Mutation_p.P62H|LGALS9C_ENST00000583322.1_Intron|LGALS9C_ENST00000581545.1_Intron|LGALS9C_ENST00000584941.1_Intron	NM_001040078.2	NP_001035167.2	Q6DKI2	LEG9C_HUMAN	lectin, galactoside-binding, soluble, 9C	150							sugar binding			NS(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	7						TAACAGAATCCCCGCGCAGTC	0.587000													17	33					1.5739e-10	1.81212e-10	0.028581	1	0
FRG1B	284802	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													4	157					0	0	0.029380	0	0
DCDC1	341019	broad.mit.edu	37	11	30938475	30938475	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:30938475G>T	ENST00000597505.1	-	24	3393	c.3394C>A	c.(3394-3396)Ctt>Att	p.L1132I	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.L211I			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TTCTTTGGAAGACTGTCATCC	0.418000													44	110					2.35958e-20	3.10182e-20	0.111260	1	0
RTTN	25914	broad.mit.edu	37	18	67794780	67794780	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr18:67794780C>G	ENST00000255674.6	-	25	3627	c.3341G>C	c.(3340-3342)gGg>gCg	p.G1114A	RTTN_ENST00000437017.1_Missense_Mutation_p.G1114A|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1114							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CAAGGTAACCCCACATGGACC	0.488000													86	67					0	0	0.048971	0	0
TLN2	83660	broad.mit.edu	37	15	62948149	62948149	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:62948149G>A	ENST00000561311.1	+	7	754	c.524G>A	c.(523-525)tGg>tAg	p.W175*	TLN2_ENST00000306829.6_Nonsense_Mutation_p.W175*			Q9Y4G6	TLN2_HUMAN	talin 2	175	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GCAGTAAATTGGCTGGATCAC	0.378000													24	50					0	0	0.091800	0	0
TP53	7157	broad.mit.edu	37	17	7577531	7577531	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:7577531G>A	ENST00000420246.2	-	7	882	c.750C>T	c.(748-750)ccC>ccT	p.P250P	TP53_ENST00000445888.2_Silent_p.P250P|TP53_ENST00000413465.2_Silent_p.P250P|TP53_ENST00000359597.4_Silent_p.P250P|TP53_ENST00000455263.2_Silent_p.P250P|TP53_ENST00000269305.4_Silent_p.P250P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	250	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		P -> A (in sporadic cancers; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(5)|p.P250P(4)|p.P250L(2)|p.M246_P250delMNRRP(2)|p.P250_L252delPIL(2)|p.P250Q(2)|p.N247_P250delNRRP(1)|p.R248_P250delRRP(1)|p.P250_T253delPILT(1)|p.P250_I251insXXXXXX(1)|p.P250_I251insXXXXXXX(1)|p.R249_P250delRP(1)|p.P250_I251insX(1)|p.I251fs*96(1)|p.R249_T256delRPILTIIT(1)|p.R249_I251delRPI(1)|p.I251fs*13(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGATGGGCCTCCGGT	0.577000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			180	30					0	0	0.048971	0	0
ZW10	9183	broad.mit.edu	37	11	113607343	113607343	+	Splice_Site	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:113607343G>A	ENST00000200135.3	-	15	2362	c.2219_splice	c.e15+1	p.R740_splice		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	740					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TATACATACCGATCCCCAATT	0.418000													179	361					0	0	0.048971	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923158	35923158	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:35923158A>G	ENST00000490799.1	-	17	2356	c.2003T>C	c.(2002-2004)gTg>gCg	p.V668A	SLC26A8_ENST00000355574.2_Missense_Mutation_p.V668A|SLC26A8_ENST00000394602.2_Missense_Mutation_p.V563A	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	668	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TTTCTGAGACACGGACGATAC	0.473000													153	250					0	0	0.048971	0	0
PRX	57716	broad.mit.edu	37	19	40902381	40902381	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:40902381G>T	ENST00000324001.7	-	7	2148	c.1878C>A	c.(1876-1878)gtC>gtA	p.V626V	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	626	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCATCTCTGGGACTTTTGGAA	0.577000													260	285					7.64293e-143	1.39093e-142	0.048971	1	0
KLHL1	57626	broad.mit.edu	37	13	70293521	70293521	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:70293521C>A	ENST00000377844.4	-	9	2754	c.1995G>T	c.(1993-1995)cgG>cgT	p.R665R	KLHL1_ENST00000545028.1_Silent_p.R472R	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	665					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AATCCAGTAGCCGGGAACAGT	0.463000													168	128					2.67785e-60	4.61299e-60	0.048971	1	0
NWD1	284434	broad.mit.edu	37	19	16870093	16870093	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:16870093G>T	ENST00000524140.2	+	7	2245	c.1827G>T	c.(1825-1827)ctG>ctT	p.L609L	NWD1_ENST00000339803.6_Silent_p.L474L|NWD1_ENST00000379808.3_Silent_p.L609L|NWD1_ENST00000552788.1_Silent_p.L609L|NWD1_ENST00000549814.1_Silent_p.L609L|NWD1_ENST00000523826.1_Silent_p.L403L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	609	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ACGAGGTCCTGCAGGATGTGT	0.612000													84	124					3.31034e-53	5.54727e-53	0.048971	1	0
KALRN	8997	broad.mit.edu	37	3	124211729	124211729	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:124211729G>T	ENST00000360013.3	+	32	4953	c.4826_splice	c.e32+1	p.R1609_splice	KALRN_ENST00000240874.3_Splice_Site_p.R1609_splice|KALRN_ENST00000460856.1_Splice_Site_p.R1600_splice	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1609					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AATAGTAAGAGGTAACCAGCA	0.522000													26	43					1.33986e-20	1.7682e-20	0.099896	1	0
USP32	84669	broad.mit.edu	37	17	58270219	58270219	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:58270219C>A	ENST00000300896.4	-	28	3701	c.3507G>T	c.(3505-3507)tgG>tgT	p.W1169C	USP32_ENST00000592339.1_Missense_Mutation_p.W839C	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1169					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACCATGGGCACCAAGCACAGG	0.378000													75	136					4.00405e-42	6.30405e-42	0.048971	1	0
PGM5P2	595135	broad.mit.edu	37	9	69117767	69117767	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:69117767G>T	ENST00000591037.1	-	0	827					NR_002836.2																						CAGTTGGCTGGGCCCAGTCAG	0.448000													136	163					1.60242e-51	2.64594e-51	0.048971	1	0
DUSP27	92235	broad.mit.edu	37	1	167096834	167096834	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:167096834C>T	ENST00000361200.2	+	6	2632	c.2466C>T	c.(2464-2466)ccC>ccT	p.P822P	DUSP27_ENST00000443333.1_Silent_p.P822P|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Silent_p.P822P			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	822					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGCAAGCCCATCTTCAGCC	0.527000													46	99					0	0	0.048971	0	0
TRAF3	7187	broad.mit.edu	37	14	103369758	103369758	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:103369758G>A	ENST00000560371.1	+	10	1344	c.1127G>A	c.(1126-1128)cGg>cAg	p.R376Q	TRAF3_ENST00000539721.1_Missense_Mutation_p.R293Q|TRAF3_ENST00000392745.2_Missense_Mutation_p.R376Q|TRAF3_ENST00000351691.5_Missense_Mutation_p.R351Q|TRAF3_ENST00000347662.4_Missense_Mutation_p.R351Q	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	376					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		CAAGTGGCTCGGAACACAGGT	0.672000													14	41					0	0	0.024245	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133674019	133674019	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:133674019T>A	ENST00000310926.4	-	4	689	c.416A>T	c.(415-417)cAg>cTg	p.Q139L	SLCO2A1_ENST00000493729.1_Intron	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	139					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GAGCTCGGCCTGCAAGCGGCT	0.632000													10	14					0	0	0.080935	0	0
CLCA2	9635	broad.mit.edu	37	1	86891153	86891153	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:86891153T>A	ENST00000370565.4	+	2	480	c.318T>A	c.(316-318)taT>taA	p.Y106*		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	106					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AAGAATCATATGAAAAGGTAA	0.294000													28	26					0	0	0.041601	0	0
ZNF527	84503	broad.mit.edu	37	19	37879596	37879596	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:37879596G>T	ENST00000436120.2	+	5	752	c.645G>T	c.(643-645)gaG>gaT	p.E215D	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCATGCTGAGAAGGAATCTT	0.343000													49	102					7.05377e-20	9.23675e-20	0.048971	1	0
GMEB1	10691	broad.mit.edu	37	1	29040746	29040746	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:29040746C>T	ENST00000373816.1	+	10	1291	c.1153C>T	c.(1153-1155)Cct>Tct	p.P385S	GMEB1_ENST00000480454.1_3'UTR|GMEB1_ENST00000361872.4_Missense_Mutation_p.P385S|GMEB1_ENST00000294409.2_Missense_Mutation_p.P395S	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCCCTTCTCCTCCTGTCCA	0.562000													22	29					0	0	0.037714	0	0
ATOH8	84913	broad.mit.edu	37	2	85981923	85981923	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:85981923A>G	ENST00000306279.3	+	1	907	c.611A>G	c.(610-612)cAg>cGg	p.Q204R	ATOH8_ENST00000463422.1_3'UTR	NM_032827.6	NP_116216.2	Q96SQ7	ATOH8_HUMAN	atonal homolog 8 (Drosophila)	204					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	5						AATAACCACCAGGATTCCTCC	0.652000													31	79					0	0	0.054565	0	0
HEPHL1	341208	broad.mit.edu	37	11	93815724	93815724	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:93815724C>A	ENST00000315765.9	+	10	1865	c.1857C>A	c.(1855-1857)aaC>aaA	p.N619K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	619	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TGAAATCCAACCGAATGCATG	0.348000													15	39					6.72482e-11	7.79573e-11	0.024245	1	0
PDE6A	5145	broad.mit.edu	37	5	149286877	149286877	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:149286877G>T	ENST00000255266.5	-	7	1182	c.1063C>A	c.(1063-1065)Ctg>Atg	p.L355M		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	355	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTACTTACCAGGCCATTCTGG	0.463000													177	225					1.00621e-116	1.8214e-116	0.048971	1	0
PKHD1	5314	broad.mit.edu	37	6	51613225	51613225	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:51613225G>T	ENST00000371117.3	-	58	9464	c.9189C>A	c.(9187-9189)aaC>aaA	p.N3063K	PKHD1_ENST00000340994.4_Missense_Mutation_p.N3063K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3063					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GAACCACAAGGTTATTAGTGA	0.483000													110	147					1.15365e-47	1.87295e-47	0.048971	1	0
SELE	6401	broad.mit.edu	37	1	169698390	169698390	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:169698390C>A	ENST00000333360.7	-	7	1166	c.1027G>T	c.(1027-1029)Gga>Tga	p.G343*	SELE_ENST00000367777.1_Nonsense_Mutation_p.G343*|SELE_ENST00000367776.1_Nonsense_Mutation_p.G343*|SELE_ENST00000367775.1_Nonsense_Mutation_p.G281*|SELE_ENST00000367779.4_Nonsense_Mutation_p.G343*|SELE_ENST00000367782.4_Nonsense_Mutation_p.G343*|SELE_ENST00000367774.1_Nonsense_Mutation_p.G343*|SELE_ENST00000367781.4_Nonsense_Mutation_p.G343*|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Nonsense_Mutation_p.G281*	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	343	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TGGGCTGGTCCCTGCAACATG	0.498000													66	43					7.46257e-40	1.16678e-39	0.048971	1	0
ZNF354C	30832	broad.mit.edu	37	5	178505712	178505712	+	Silent	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:178505712A>G	ENST00000315475.6	+	5	585	c.279A>G	c.(277-279)gcA>gcG	p.A93A		NM_014594.1	NP_055409.1	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	93					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|urinary_tract(3)	30	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AAACAGAAGCATTGCCTCATA	0.373000													53	51					0	0	0.048971	0	0
BNC1	646	broad.mit.edu	37	15	83932935	83932935	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:83932935C>T	ENST00000345382.2	-	4	1153	c.1068G>A	c.(1066-1068)cgG>cgA	p.R356R	BNC1_ENST00000569704.1_Silent_p.R349R|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	356					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TGCAGAACACCCGGCCCTTCT	0.478000													5	183					0	0	0.021553	0	0
DLAT	1737	broad.mit.edu	37	11	111922022	111922022	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:111922022G>T	ENST00000280346.6	+	11	2122	c.1463G>T	c.(1462-1464)tGt>tTt	p.C488F	DLAT_ENST00000537636.1_Missense_Mutation_p.C259F|DLAT_ENST00000393051.1_Missense_Mutation_p.C383F	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	488	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	GCTTTGGCATGTTTAAAAGTT	0.343000													77	60					1.5608e-48	2.55496e-48	0.048971	1	0
SI	6476	broad.mit.edu	37	3	164780197	164780197	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:164780197C>A	ENST00000264382.3	-	9	1044	c.982G>T	c.(982-984)Gga>Tga	p.G328*		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	328	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGTGTATCTCCTAGAAGGATG	0.328000										HNSCC(35;0.089)			25	50					7.01153e-11	8.1142e-11	0.034045	1	0
RIT2	6014	broad.mit.edu	37	18	40554090	40554090	+	Silent	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr18:40554090G>C	ENST00000589109.1	-	3	354	c.183C>G	c.(181-183)gtC>gtG	p.V61V	RIT2_ENST00000326695.5_Silent_p.V61V|RIT2_ENST00000282028.4_Silent_p.V61V|RIT2_ENST00000590910.1_Silent_p.V61V	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	61					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGTCAATCCTGACCTGGGTCT	0.363000													25	33					0	0	0.037714	0	0
SEMA5B	54437	broad.mit.edu	37	3	122667529	122667529	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:122667529G>T	ENST00000195173.4	-	3	455	c.152C>A	c.(151-153)gCt>gAt	p.A51D	SEMA5B_ENST00000357599.3_Missense_Mutation_p.A51D|SEMA5B_ENST00000465147.1_5'UTR|SEMA5B_ENST00000451055.2_Missense_Mutation_p.A105D			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	51					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGCAGTCCTAGCTCCGGGAGG	0.607000													18	57					1.56452e-12	1.84206e-12	0.043863	1	0
NID1	4811	broad.mit.edu	37	1	236192981	236192981	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:236192981C>A	ENST00000264187.6	-	7	1689	c.1607G>T	c.(1606-1608)cGg>cTg	p.R536L	NID1_ENST00000366595.3_Missense_Mutation_p.R536L	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	536	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCCGCTGAACCGCTGCTTAAT	0.602000													12	22					9.31168e-06	9.83464e-06	0.105934	1	0
KIAA0922	23240	broad.mit.edu	37	4	154510157	154510157	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:154510157C>T	ENST00000409663.3	+	16	1717	c.1665C>T	c.(1663-1665)tgC>tgT	p.C555C	KIAA0922_ENST00000440693.1_Silent_p.C556C|KIAA0922_ENST00000409959.3_Silent_p.C556C	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	555						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				GTGACGTCTGCAAGTACGTCT	0.448000													29	56					0	0	0.054565	0	0
SNX1	6642	broad.mit.edu	37	15	64423929	64423929	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:64423929G>T	ENST00000353874.4	+	11	1095	c.1059G>T	c.(1057-1059)atG>atT	p.M353I	SNX1_ENST00000559844.1_Missense_Mutation_p.M353I|SNX1_ENST00000561026.1_Missense_Mutation_p.M288I|SNX1_ENST00000560829.1_Missense_Mutation_p.M135I|SNX1_ENST00000261889.5_Missense_Mutation_p.M353I			Q13596	SNX1_HUMAN	sorting nexin 1	353	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						GTCTAGCCATGCTTGGGAGCT	0.532000													33	52					1.47197e-15	1.8386e-15	0.098360	1	0
A1CF	29974	broad.mit.edu	37	10	52603771	52603771	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:52603771C>A	ENST00000395489.2	-	6	586	c.190G>T	c.(190-192)Gag>Tag	p.E64*	A1CF_ENST00000373993.1_Nonsense_Mutation_p.E71*|A1CF_ENST00000395495.1_Nonsense_Mutation_p.E71*|A1CF_ENST00000373995.3_Nonsense_Mutation_p.E79*|A1CF_ENST00000374001.1_Nonsense_Mutation_p.E71*|A1CF_ENST00000282641.2_Nonsense_Mutation_p.E71*|A1CF_ENST00000373997.3_Nonsense_Mutation_p.E71*	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	71	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGTATAAGCTCATCCTCAAAA	0.388000													67	88					2.40885e-21	3.20391e-21	0.048971	1	0
PLEC	5339	broad.mit.edu	37	8	144995163	144995163	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:144995163C>A	ENST00000322810.4	-	32	9406	c.9237G>T	c.(9235-9237)ctG>ctT	p.L3079L	PLEC_ENST00000436759.2_Silent_p.L2969L|PLEC_ENST00000398774.2_Silent_p.L2910L|PLEC_ENST00000345136.3_Silent_p.L2942L|PLEC_ENST00000527096.1_Silent_p.L2965L|PLEC_ENST00000356346.3_Silent_p.L2928L|PLEC_ENST00000354958.2_Silent_p.L2920L|PLEC_ENST00000354589.3_Silent_p.L2942L|PLEC_ENST00000357649.2_Silent_p.L2946L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3079	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GGAACTGCCGCAGCAGGTCCC	0.597000													12	18					0.0167234	0.0169741	0.105934	1	0
DGCR14	8220	broad.mit.edu	37	22	19132106	19132106	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:19132106C>A	ENST00000252137.6	-	1	91	c.48G>T	c.(46-48)gcG>gcT	p.A16A		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	16					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					GGGGCCTGGACGCGGCGGGAA	0.677000													8	0					9.31168e-06	9.83464e-06	0.105934	1	0
MIR7-3HG	284424	broad.mit.edu	37	19	4770765	4770765	+	RNA	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:4770765G>A	ENST00000586721.1	+	0	509				MIR7-3_ENST00000384898.1_RNA																							AGTCACAGCCGGCCTCATAGC	0.557000													172	284					0	0	0.048971	0	0
ZNF208	7757	broad.mit.edu	37	19	22155984	22155984	+	Missense_Mutation	SNP	A	A	G	rs34025466		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:22155984A>G	ENST00000397126.4	-	4	2000	c.1852T>C	c.(1852-1854)Ttt>Ctt	p.F618L	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACCTTACTAAAGGTTTTGCCA	0.368000													99	121					0	0	0.048971	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6068579	6068579	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:6068579T>C	ENST00000199389.6	-	12	1563	c.1417A>G	c.(1417-1419)Aac>Gac	p.N473D	EIF2AK1_ENST00000536084.1_Missense_Mutation_p.N349D	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	473	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CAGTCTGTGTTCTTCTGTAGG	0.373000													33	229					0	0	0.086207	0	0
KIF1B	23095	broad.mit.edu	37	1	10338104	10338104	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:10338104C>T	ENST00000377086.1	+	13	1300	c.1098C>T	c.(1096-1098)gcC>gcT	p.A366A	KIF1B_ENST00000377081.1_Silent_p.A366A|KIF1B_ENST00000377093.4_Silent_p.A360A|KIF1B_ENST00000263934.6_Silent_p.A360A|KIF1B_ENST00000377083.1_Silent_p.A360A			O60333	KIF1B_HUMAN	kinesin family member 1B	366					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACCCCAATGCCAAACTGGTTC	0.398000													43	118					0	0	0.042209	0	0
ZEB2	9839	broad.mit.edu	37	2	145156031	145156031	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:145156031G>T	ENST00000558170.2	-	8	3907	c.2723C>A	c.(2722-2724)aCt>aAt	p.T908N	ZEB2_ENST00000539609.3_Missense_Mutation_p.T884N|ZEB2_ENST00000303660.4_Missense_Mutation_p.T908N|ZEB2_ENST00000409487.3_Missense_Mutation_p.T908N	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	908						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGGCATGAAAGTAGCAGGGGG	0.498000													133	151					5.62627e-71	9.86783e-71	0.048971	1	0
ST7	7982	broad.mit.edu	37	7	116830916	116830916	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:116830916G>T	ENST00000265437.5	+	12	1394	c.1180G>T	c.(1180-1182)Ggg>Tgg	p.G394W	ST7_ENST00000487459.1_3'UTR|ST7_ENST00000393444.3_Missense_Mutation_p.G328W|ST7_ENST00000393443.1_Missense_Mutation_p.G321W|ST7_ENST00000432298.1_Missense_Mutation_p.G348W|ST7_ENST00000393446.2_Missense_Mutation_p.G371W|ST7_ENST00000422922.1_Missense_Mutation_p.G325W|ST7_ENST00000393447.4_Missense_Mutation_p.G351W|ST7_ENST00000393449.1_Missense_Mutation_p.G394W|ST7_ENST00000393451.3_Missense_Mutation_p.G371W|ST7_ENST00000323984.3_Missense_Mutation_p.G394W	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	394						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ATCTCGGCGGGGGCTGAGCAC	0.512000													41	101					3.68337e-26	5.13095e-26	0.048971	1	0
EVC	2121	broad.mit.edu	37	4	5750010	5750010	+	Missense_Mutation	SNP	G	G	T	rs150923920	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:5750010G>T	ENST00000382674.2	+	8	1259	c.1075G>T	c.(1075-1077)Gat>Tat	p.D359Y	EVC_ENST00000264956.6_Missense_Mutation_p.D359Y|EVC_ENST00000509451.1_Missense_Mutation_p.D359Y			P57679	EVC_HUMAN	Ellis van Creveld syndrome	359					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				GCTATTGTGCGATTCTCAGGA	0.498000													44	92					8.04919e-23	1.09204e-22	0.048971	1	0
CLIP2	7461	broad.mit.edu	37	7	73768238	73768238	+	Missense_Mutation	SNP	G	G	A	rs150032298		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:73768238G>A	ENST00000223398.6	+	4	1034	c.707G>A	c.(706-708)cGg>cAg	p.R236Q	CLIP2_ENST00000395060.1_Missense_Mutation_p.R236Q|CLIP2_ENST00000361545.5_Missense_Mutation_p.R236Q	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	236						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GGCGTGGTGCGGTACGTGGGG	0.647000													159	295					0	0	0.048971	0	0
FYB	2533	broad.mit.edu	37	5	39153643	39153643	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:39153643G>A	ENST00000351578.6	-	3	1389	c.1199C>T	c.(1198-1200)cCg>cTg	p.P400L	FYB_ENST00000515010.1_Missense_Mutation_p.P400L|FYB_ENST00000540520.1_Missense_Mutation_p.P410L|FYB_ENST00000512982.1_Missense_Mutation_p.P400L|FYB_ENST00000505428.1_Missense_Mutation_p.P400L	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	400	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TTGGCTGGCCGGATGGGATGG	0.493000													5	343					0	0	0.014758	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450836	105450836	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:105450836T>C	ENST00000337685.2	+	5	2196	c.1411T>C	c.(1411-1413)Tca>Cca	p.S471P	MUM1L1_ENST00000357175.2_Missense_Mutation_p.S471P|MUM1L1_ENST00000372552.1_Missense_Mutation_p.S471P	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	471										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTGGTGCATCTCACTAATTTG	0.363000													3	124					0	0	0.004672	0	0
SELE	6401	broad.mit.edu	37	1	169698391	169698391	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:169698391C>T	ENST00000333360.7	-	7	1165	c.1026G>A	c.(1024-1026)caG>caA	p.Q342Q	SELE_ENST00000367777.1_Silent_p.Q342Q|SELE_ENST00000367776.1_Silent_p.Q342Q|SELE_ENST00000367775.1_Silent_p.Q280Q|SELE_ENST00000367779.4_Silent_p.Q342Q|SELE_ENST00000367782.4_Silent_p.Q342Q|SELE_ENST00000367774.1_Silent_p.Q342Q|SELE_ENST00000367781.4_Silent_p.Q342Q|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Silent_p.Q280Q	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	342	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GGGCTGGTCCCTGCAACATGA	0.493000													66	43					0	0	0.048971	0	0
MVB12A	93343	broad.mit.edu	37	19	17533201	17533201	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:17533201A>T	ENST00000317040.7	+	4	1402	c.347A>T	c.(346-348)gAc>gTc	p.D116V	MVB12A_ENST00000392702.2_Missense_Mutation_p.D116V|MVB12A_ENST00000528515.1_Intron|MVB12A_ENST00000543795.1_Missense_Mutation_p.D116V|MVB12A_ENST00000529939.1_Missense_Mutation_p.D116V					multivesicular body subunit 12A																		GGAGCCACGGACACGGCTGTG	0.602000													33	37					0	0	0.080422	0	0
LPHN2	23266	broad.mit.edu	37	1	82456358	82456358	+	Silent	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:82456358A>T	ENST00000370728.1	+	25	4554	c.3909A>T	c.(3907-3909)gcA>gcT	p.A1303A	LPHN2_ENST00000359929.3_Silent_p.A1247A|LPHN2_ENST00000370727.1_Silent_p.A1275A|LPHN2_ENST00000370730.1_Silent_p.A1260A|LPHN2_ENST00000394879.1_Silent_p.A1305A|LPHN2_ENST00000370713.1_3'UTR|LPHN2_ENST00000370715.1_3'UTR|LPHN2_ENST00000370725.1_Silent_p.A1318A|LPHN2_ENST00000370717.2_Silent_p.A1318A|LPHN2_ENST00000370721.1_Silent_p.A1228A|LPHN2_ENST00000319517.6_Silent_p.A1247A|LPHN2_ENST00000335786.5_Silent_p.A1260A|LPHN2_ENST00000271029.4_Silent_p.A1275A|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000370723.1_Silent_p.A1305A			O95490	LPHN2_HUMAN	latrophilin 2	1303					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTATTGTGGCAGATGCTTCAT	0.517000													28	46					0	0	0.092188	0	0
IFRD1	3475	broad.mit.edu	37	7	112096994	112096994	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:112096994G>A	ENST00000403825.3	+	4	571	c.310G>A	c.(310-312)Gaa>Aaa	p.E104K	IFRD1_ENST00000535603.1_Missense_Mutation_p.E54K|IFRD1_ENST00000429071.1_Missense_Mutation_p.E104K|IFRD1_ENST00000005558.4_Missense_Mutation_p.E104K	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	104					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						AGCAGCTCTTGAAGGTATTAA	0.343000													77	130					0	0	0.048971	0	0
OR14C36	127066	broad.mit.edu	37	1	248512562	248512562	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:248512562C>A	ENST00000317861.1	+	1	486	c.486C>A	c.(484-486)ttC>ttA	p.F162L		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						GCAGCACATTCCAGCTGCCCT	0.512000													52	69					4.88482e-21	6.47167e-21	0.048971	1	0
TPPP2	122664	broad.mit.edu	37	14	21498833	21498833	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:21498833C>A	ENST00000321760.6	+	2	241	c.93C>A	c.(91-93)tcC>tcA	p.S31S	TPPP2_ENST00000460647.2_Silent_p.S31S|NDRG2_ENST00000403829.3_Intron|TPPP2_ENST00000530140.2_Silent_p.S31S	NM_173846.4	NP_776245.2	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family member 2	31						cytoplasm				endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		AGAACTTCTCCAAGCTGTGCA	0.478000													49	56					8.86878e-18	1.13715e-17	0.048971	1	0
WSB1	26118	broad.mit.edu	37	17	25630530	25630530	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:25630530G>T	ENST00000262394.2	+	3	663	c.347G>T	c.(346-348)gGg>gTg	p.G116V	WSB1_ENST00000581185.1_Missense_Mutation_p.G116V|WSB1_ENST00000427287.2_Missense_Mutation_p.G85V|WSB1_ENST00000583193.1_Intron|WSB1_ENST00000579733.1_Intron|WSB1_ENST00000348811.2_Intron	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	116					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CTTGCTTTTGGGTCATCAGTT	0.393000													189	124					3.7662e-97	6.78117e-97	0.048971	1	0
SHROOM4	57477	broad.mit.edu	37	X	50351111	50351111	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:50351111C>A	ENST00000376020.2	-	6	3056	c.3031G>T	c.(3031-3033)Gac>Tac	p.D1011Y	SHROOM4_ENST00000289292.7_Missense_Mutation_p.D1011Y|SHROOM4_ENST00000460112.3_Missense_Mutation_p.D895Y	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1011					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTTGACAAGTCCAGTGCTGGG	0.453000													58	5					1.00798e-23	1.37581e-23	0.048971	1	0
TPTE	7179	broad.mit.edu	37	21	10934087	10934087	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:10934087T>A	ENST00000298232.7	-	15	1203	c.836A>T	c.(835-837)aAt>aTt	p.N279I	TPTE_ENST00000342420.5_Missense_Mutation_p.N259I|TPTE_ENST00000361285.4_Missense_Mutation_p.N297I|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	297	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AACGACCCTATTATGGAAGTG	0.328000													49	98					0	0	0.048971	0	0
KRT85	3891	broad.mit.edu	37	12	52758935	52758935	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:52758935T>A	ENST00000257901.3	-	2	515	c.440A>T	c.(439-441)cAg>cTg	p.Q147L		NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	147	Coil 1A.|Rod.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGCTTGTTCTGCTGCTCCAG	0.607000													10	43					0	0	0.030593	0	0
PRDM15	63977	broad.mit.edu	37	21	43279791	43279791	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:43279791C>A	ENST00000422911.1	-	3	253	c.152G>T	c.(151-153)tGt>tTt	p.C51F	PRDM15_ENST00000269844.3_Missense_Mutation_p.C314F|PRDM15_ENST00000398548.1_Missense_Mutation_p.C51F|PRDM15_ENST00000447207.2_Missense_Mutation_p.C14F|PRDM15_ENST00000538201.1_Missense_Mutation_p.C14F			P57071	PRD15_HUMAN	PR domain containing 15	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						GCAGTCTTCACACCCTGCAAG	0.577000													8	24					0.0381472	0.0386034	0.038147	1	0
LYST	1130	broad.mit.edu	37	1	235827894	235827894	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:235827894C>A	ENST00000389794.3	-	51	11240	c.11066G>T	c.(11065-11067)tGg>tTg	p.W3689L	LYST_ENST00000389793.2_Missense_Mutation_p.W3689L|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3689					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GTTCACCGTCCAGAGTCTGAG	0.547000													29	39					4.02929e-09	4.52376e-09	0.045705	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125671764	125671764	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:125671764A>T	ENST00000431078.1	+	24	4184	c.3820A>T	c.(3820-3822)Atg>Ttg	p.M1274L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1274					cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TACGAGCCAGATGAAGGAGAA	0.443000													70	228					0	0	0.048971	0	0
CDH17	1015	broad.mit.edu	37	8	95186447	95186447	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:95186447G>A	ENST00000027335.3	-	6	590	c.466C>T	c.(466-468)Ccg>Tcg	p.P156S	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Missense_Mutation_p.P156S	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	156	Cadherin 2.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GGAGTGGCCGGATCATCCAGG	0.413000													84	164					0	0	0.048971	0	0
MYOM2	9172	broad.mit.edu	37	8	2000375	2000375	+	Missense_Mutation	SNP	G	G	T	rs138096233	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:2000375G>T	ENST00000262113.4	+	3	348	c.207G>T	c.(205-207)agG>agT	p.R69S	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	69					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCATCTGCAGGGTCTGTGCGA	0.607000													64	73					1.52808e-22	2.06902e-22	0.048971	1	0
IGSF3	3321	broad.mit.edu	37	1	117146563	117146563	+	Missense_Mutation	SNP	G	G	A	rs61786578		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:117146563G>A	ENST00000369486.3	-	6	2072	c.1307C>T	c.(1306-1308)aCg>aTg	p.T436M	IGSF3_ENST00000318837.6_Missense_Mutation_p.T456M|IGSF3_ENST00000369483.1_Missense_Mutation_p.T456M	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	436	Ig-like C2-type 4.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCTGCCTGCCGTGCGGACACT	0.627000													59	85					0	0	0.048971	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354438	17354438	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:17354438G>T	ENST00000511821.1	+	0	297				FTH1P10_ENST00000401830.3_RNA																							GGTAAACGCAGGAGGCGTAGA	0.542000													29	43					1.2476e-16	1.57874e-16	0.030593	1	0
ZW10	9183	broad.mit.edu	37	11	113607342	113607342	+	Splice_Site	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:113607342C>G	ENST00000200135.3	-	15	2363	c.2219_splice	c.e15+1	p.R740_splice		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	740					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTATACATACCGATCCCCAAT	0.413000													174	356					0	0	0.048971	0	0
NETO1	81832	broad.mit.edu	37	18	70461478	70461478	+	Splice_Site	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr18:70461478C>T	ENST00000327305.6	-	6	1170	c.511_splice	c.e6-1	p.A171_splice	NETO1_ENST00000299430.2_Splice_Site_p.A170_splice|NETO1_ENST00000583169.1_Splice_Site_p.A171_splice	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	171					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity	p.A171A(1)		NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CAAACTCACACGCTAAATAAC	0.388000													34	67					0	0	0.050027	0	0
TBX3	6926	broad.mit.edu	37	12	115112301	115112301	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:115112301G>C	ENST00000349155.2	-	6	2342	c.1379C>G	c.(1378-1380)gCg>gGg	p.A460G	TBX3_ENST00000257566.3_Missense_Mutation_p.A480G	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	480					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGTGAGCGGCGCGAAGGCCTC	0.781000													2	3					0	0	0.009096	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54603855	54603855	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:54603855T>C	ENST00000474759.1	+	7	758	c.710T>C	c.(709-711)aTt>aCt	p.I237T	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.I143T|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.I237T|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.I237T	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	237						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AATGGAGTCATTGCCTTCGAC	0.383000													4	9					0	0	0.014758	0	0
USP33	23032	broad.mit.edu	37	1	78181454	78181454	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:78181454T>A	ENST00000370793.1	-	19	2457	c.2111A>T	c.(2110-2112)aAt>aTt	p.N704I	USP33_ENST00000370792.3_Missense_Mutation_p.N696I|USP33_ENST00000370794.3_Missense_Mutation_p.N673I|USP33_ENST00000357428.1_Missense_Mutation_p.N704I	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	704					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						AGCTTCTGCATTTTGTACAGT	0.373000													29	35					0	0	0.037714	0	0
IVL	3713	broad.mit.edu	37	1	152883676	152883676	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:152883676A>T	ENST00000368764.3	+	2	1467	c.1403A>T	c.(1402-1404)aAg>aTg	p.K468M	IVL_ENST00000392667.2_Missense_Mutation_p.K322M			P07476	INVO_HUMAN	involucrin	468	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGGAGGAGAAGCAACTGGAG	0.617000													4	3					0	0	0.014758	0	0
GRM8	2918	broad.mit.edu	37	7	126173024	126173024	+	Silent	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:126173024T>A	ENST00000339582.2	-	9	3220	c.2412A>T	c.(2410-2412)acA>acT	p.T804T	GRM8_ENST00000358373.3_Silent_p.T804T|GRM8_ENST00000444921.2_Silent_p.T804T			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	804					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTGACTGGGCTGTACCAAAAA	0.393000										HNSCC(24;0.065)			70	79					0	0	0.048971	0	0
AQP12A	375318	broad.mit.edu	37	2	241631351	241631351	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:241631351C>T	ENST00000429564.1	+	1	84	c.21C>T	c.(19-21)tcC>tcT	p.S7S	AQP12A_ENST00000337801.4_Silent_p.S7S			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	7						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		TTAACGTGTCCCTCTCCTTCT	0.667000													34	47					0	0	0.086207	0	0
ACSM1	116285	broad.mit.edu	37	16	20648732	20648732	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:20648732C>A	ENST00000219151.4	-	8	1225	c.15G>T	c.(13-15)ccG>ccT	p.P5P	ACSM1_ENST00000307493.4_Silent_p.P386P|ACSM1_ENST00000520010.1_Silent_p.P386P			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	386					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding	p.P5P(1)|p.P386P(1)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CCATGAAACCCGGCTTGATCT	0.527000													112	30					1.36713e-32	2.01207e-32	0.048971	1	0
PLCH2	9651	broad.mit.edu	37	1	2428372	2428372	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:2428372G>T	ENST00000449969.1	+	15	2119	c.1958G>T	c.(1957-1959)cGc>cTc	p.R653L	PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000378486.3_Missense_Mutation_p.R680L|PLCH2_ENST00000378488.3_Missense_Mutation_p.R680L|PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000419816.2_Missense_Mutation_p.R680L			O75038	PLCH2_HUMAN	phospholipase C, eta 2	680	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CAGCTCTCCCGCATCTACCCC	0.632000													14	12					6.94344e-10	7.90035e-10	0.038395	1	0
MT-ND4	4538	broad.mit.edu	37	MT	11475	11475	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrM:11475G>A	ENST00000361381.2	+	1	716	c.716G>A	c.(715-717)gGc>gAc	p.239_239insD						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CTTAAAACTAGGCGGCTATGG	0.463000													4	0					0	0	0.009096	0	0
SART1	9092	broad.mit.edu	37	11	65745041	65745041	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:65745041G>T	ENST00000312397.5	+	16	2045	c.1953G>T	c.(1951-1953)ctG>ctT	p.L651L		NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	651					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TAGGGCTGCTGGAGACCACAG	0.647000													16	46					5.3912e-06	5.72974e-06	0.038395	1	0
DDX1	1653	broad.mit.edu	37	2	15770224	15770224	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:15770224G>T	ENST00000381341.2	+	26	2471	c.2082G>T	c.(2080-2082)agG>agT	p.R694S	DDX1_ENST00000233084.3_Missense_Mutation_p.R694S			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	694	Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GTCAGAAAAGGGCTGCTGGTG	0.368000													11	162					6.56871e-35	9.88226e-35	0.048971	1	0
CALCRL	10203	broad.mit.edu	37	2	188247947	188247947	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:188247947T>A	ENST00000409998.1	-	6	918	c.137A>T	c.(136-138)tAt>tTt	p.Y46F	AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.Y46F|CALCRL_ENST00000410068.1_Missense_Mutation_p.Y46F			Q16602	CALRL_HUMAN	calcitonin receptor-like	46						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GTAACATTCATATTGAGCTGT	0.338000													88	109					0	0	0.048971	0	0
FBN1	2200	broad.mit.edu	37	15	48741007	48741007	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:48741007G>A	ENST00000316623.5	-	46	6084	c.5629C>T	c.(5629-5631)Cac>Tac	p.H1877Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1877	EGF-like 31; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AAACCAGTGTGGCAAAGGCAA	0.348000													32	39					0	0	0.054565	0	0
TRHDE	29953	broad.mit.edu	37	12	72936116	72936116	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:72936116G>T	ENST00000261180.4	+	7	1729	c.1633G>T	c.(1633-1635)Gtt>Ttt	p.V545F		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	545					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GGGCCATTCAGTTTTCCAGAG	0.303000													33	57					3.38236e-24	4.62597e-24	0.092188	1	0
RAPGEF4	11069	broad.mit.edu	37	2	173855582	173855582	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:173855582T>C	ENST00000264111.6	+	15	1603	c.1416T>C	c.(1414-1416)gaT>gaC	p.D472D	RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000409036.1_Silent_p.D473D|RAPGEF4_ENST00000538974.1_Silent_p.D302D|RAPGEF4_ENST00000397081.3_Silent_p.D473D|RAPGEF4_ENST00000535187.1_Silent_p.D253D|RAPGEF4_ENST00000540783.1_Silent_p.D320D|RAPGEF4_ENST00000397087.3_Silent_p.D329D|RAPGEF4_ENST00000539331.1_Silent_p.D320D			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	473					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			ATGACCAAGATGTCTTGGTGC	0.448000													22	39					0	0	0.034045	0	0
MSR1	4481	broad.mit.edu	37	8	16001085	16001085	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:16001085C>T	ENST00000350896.3	-	8	1212	c.1015G>A	c.(1015-1017)Ggg>Agg	p.G339R	MSR1_ENST00000381998.4_Missense_Mutation_p.G339R|MSR1_ENST00000355282.2_Missense_Mutation_p.G339R|MSR1_ENST00000536385.1_Missense_Mutation_p.G113R|MSR1_ENST00000262101.5_Missense_Mutation_p.G339R|MSR1_ENST00000445506.2_Missense_Mutation_p.G357R	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	402	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTTCCACTCCCCTTTTCCCCT	0.348000													17	42					0	0	0.038395	0	0
OR5D18	219438	broad.mit.edu	37	11	55587917	55587917	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:55587917C>A	ENST00000333976.4	+	1	832	c.812C>A	c.(811-813)aCa>aAa	p.T271K		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T271K(2)		NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCCAGGCACACAGTCAAAGTG	0.507000													82	137					2.1672e-28	3.12168e-28	0.048971	1	0
FETUB	26998	broad.mit.edu	37	3	186358877	186358877	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:186358877T>C	ENST00000265029.3	+	2	385	c.284T>C	c.(283-285)gTg>gCg	p.V95A	FETUB_ENST00000488561.1_Intron|FETUB_ENST00000382134.3_Intron|FETUB_ENST00000450521.1_Missense_Mutation_p.V95A|FETUB_ENST00000539949.1_Intron|FETUB_ENST00000382136.3_Intron	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	95	Cystatin fetuin-B-type 1.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GACTGCCATGTGCTCAGAAAG	0.448000													15	40					0	0	0.043863	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862806	10862806	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:10862806G>T	ENST00000559480.1	+	0	102																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						AGAAGCCTGGGGCCTCAGTGA	0.567000													22	63					1.7881e-09	2.01757e-09	0.037714	1	0
TTN	7273	broad.mit.edu	37	2	179484542	179484542	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:179484542G>T	ENST00000589042.1	-	250	46726	c.46502C>A	c.(46501-46503)gCa>gAa	p.A15501E	TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.A6561E|TTN_ENST00000591111.1_Missense_Mutation_p.A13860E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A12933E|TTN_ENST00000342175.6_Missense_Mutation_p.A6628E|TTN_ENST00000460472.2_Missense_Mutation_p.A6436E|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000604956.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13860							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGAGTTCTGCTAAAAAGAC	0.383000													110	96					1.12924e-63	1.96025e-63	0.048971	1	0
SPTBN4	57731	broad.mit.edu	37	19	40996038	40996038	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:40996038G>T	ENST00000352632.3	+	4	464	c.378G>T	c.(376-378)gcG>gcT	p.A126A	SPTBN4_ENST00000344104.3_Silent_p.A126A|SPTBN4_ENST00000598249.1_Silent_p.A126A|SPTBN4_ENST00000595535.1_Silent_p.A126A|SPTBN4_ENST00000338932.3_Silent_p.A126A			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	126	Actin-binding.|CH 1.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGACAAGGCGCTGCAGTTTC	0.657000													48	77					2.14674e-31	3.12547e-31	0.048971	1	0
CNTNAP3	79937	broad.mit.edu	37	9	39118245	39118245	+	Missense_Mutation	SNP	G	G	T	rs146599628		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:39118245G>T	ENST00000297668.6	-	14	2165	c.2092C>A	c.(2092-2094)Ctg>Atg	p.L698M	CNTNAP3_ENST00000323947.7_Missense_Mutation_p.L604M|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.L610M|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.L697M|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.L697M	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	698	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CACCAGCTCAGTGGGGTTCCA	0.473000													52	66					1.34568e-36	2.05648e-36	0.048971	1	0
NCAN	1463	broad.mit.edu	37	19	19344697	19344697	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:19344697G>T	ENST00000252575.5	+	9	3162	c.3119G>T	c.(3118-3120)gGg>gTg	p.G1040V	NCAN_ENST00000538881.1_Missense_Mutation_p.G491V	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1040	EGF-like 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGCTTCGCCGGGGAGAACTGT	0.522000													70	123					3.13743e-37	4.81642e-37	0.048971	1	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933578	31933578	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:31933578G>T	ENST00000334849.2	-	1	55	c.31C>A	c.(31-33)Cta>Ata	p.L11I		NM_181614.1	NP_853645.1	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	11						intermediate filament				endometrium(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	11						CCGTAGCCTAGGCCTCCATAG	0.527000													25	49					2.22609e-26	3.10734e-26	0.048971	1	0
PLXNB2	23654	broad.mit.edu	37	22	50721207	50721207	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:50721207C>T	ENST00000449103.1	-	18	3060	c.2920G>A	c.(2920-2922)Ggc>Agc	p.G974S	PLXNB2_ENST00000359337.4_Missense_Mutation_p.G974S			O15031	PLXB2_HUMAN	plexin B2	974	IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity	p.G1017S(1)		breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AAGAAGATGCCGGGGTTGGGC	0.667000													9	0					0	0	0.069234	0	0
TRAC	28755	broad.mit.edu	37	14	23020867	23020867	+	RNA	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:23020867C>A	ENST00000478163.3	+	0	744																											AGACTGCCTCCGCCATCCCAC	0.517000													106	111					1.51934e-53	2.55235e-53	0.048971	1	0
FAM120B	84498	broad.mit.edu	37	6	170626835	170626835	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:170626835C>G	ENST00000476287.1	+	2	465	c.357C>G	c.(355-357)atC>atG	p.I119M	FAM120B_ENST00000540480.1_Missense_Mutation_p.I131M|FAM120B_ENST00000537664.1_Missense_Mutation_p.I142M|FAM120B_ENST00000252510.9_Intron	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	119					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		TTCATTACATCAAGTCACACA	0.448000													55	55					0	0	0.048971	0	0
PEG3	5178	broad.mit.edu	37	19	57328635	57328635	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:57328635C>T	ENST00000326441.9	-	10	1538	c.1175G>A	c.(1174-1176)aGg>aAg	p.R392K	ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.R268K|PEG3_ENST00000593695.1_Missense_Mutation_p.R266K|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R392K|ZIM2_ENST00000601070.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	392					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATGATAGCGCCTCTTTCTTTC	0.453000													148	267					0	0	0.048971	0	0
SLC8A2	6543	broad.mit.edu	37	19	47940789	47940789	+	Silent	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:47940789C>G	ENST00000236877.6	-	8	2435	c.2040G>C	c.(2038-2040)acG>acC	p.T680T	SLC8A2_ENST00000539381.1_Silent_p.T143T|SLC8A2_ENST00000542837.1_Silent_p.T436T|SLC8A2_ENST00000601757.1_5'UTR	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	680					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AGGCCAAGTTCGTTTTCTTGA	0.547000													81	105					0	0	0.048971	0	0
OR5B2	390190	broad.mit.edu	37	11	58190697	58190697	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:58190697A>G	ENST00000302581.2	-	1	89	c.38T>C	c.(37-39)cTa>cCa	p.L13P		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGTTAGTCCTAGAAGAATGAA	0.418000													44	351					0	0	0.042209	0	0
GPM6A	2823	broad.mit.edu	37	4	176556066	176556066	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:176556066G>T	ENST00000280187.7	-	8	872	c.827C>A	c.(826-828)gCa>gAa	p.A276E	GPM6A_ENST00000515090.1_Missense_Mutation_p.A269E|GPM6A_ENST00000393658.2_Missense_Mutation_p.A276E|GPM6A_ENST00000506219.1_5'UTR|GPM6A_ENST00000506894.1_Missense_Mutation_p.A265E	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	276						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TTATGTGTATGCATTGAGCCG	0.428000													69	125					1.42748e-55	2.42206e-55	0.048971	1	0
CACNG6	59285	broad.mit.edu	37	19	54502970	54502970	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:54502970C>A	ENST00000252729.2	+	3	1079	c.489C>A	c.(487-489)ctC>ctA	p.L163L	CACNG6_ENST00000352529.1_Intron|CACNG6_ENST00000346968.2_Intron	NM_145814.1	NP_665813.1	Q9BXT2	CCG6_HUMAN	calcium channel, voltage-dependent, gamma subunit 6	163						voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		TCATGGTGCTCAGTAAAGGTG	0.592000													220	407					9.94903e-101	1.79613e-100	0.048971	1	0
STK10	6793	broad.mit.edu	37	5	171509412	171509412	+	Missense_Mutation	SNP	C	C	A	rs143931389		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:171509412C>A	ENST00000176763.5	-	12	2250	c.1907G>T	c.(1906-1908)cGg>cTg	p.R636L		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	636							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGCCTCCTCCCGGCGGCGCAC	0.557000													52	82					3.21867e-24	4.41266e-24	0.048971	1	0
COL11A1	1301	broad.mit.edu	37	1	103496798	103496798	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:103496798C>A	ENST00000358392.2	-	5	971	c.654G>T	c.(652-654)ggG>ggT	p.G218G	COL11A1_ENST00000512756.1_Silent_p.G218G|COL11A1_ENST00000353414.4_Silent_p.G218G|COL11A1_ENST00000370096.3_Silent_p.G218G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	218	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTGAATGTCCCCCTGGGAAA	0.388000													14	22					0.00316338	0.00324486	0.024245	1	0
FAM114A1	92689	broad.mit.edu	37	4	38937413	38937413	+	Splice_Site	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:38937413T>A	ENST00000358869.2	+	13	1712		c.e13+2		FAM114A1_ENST00000515037.1_Splice_Site|FAM114A1_ENST00000513966.1_Splice_Site	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1							cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						ACTGTTGGGGTAAGATTACAG	0.353000													32	55					0	0	0.045705	0	0
R3HDML	140902	broad.mit.edu	37	20	42973925	42973925	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:42973925G>T	ENST00000217043.2	+	4	708	c.536G>T	c.(535-537)cGg>cTg	p.R179L		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	179						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TCCTCCAATCGGCTGGGCTGT	0.572000													104	134					5.94134e-38	9.20432e-38	0.048971	1	0
OSBPL10	114884	broad.mit.edu	37	3	31789593	31789593	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:31789593C>T	ENST00000396556.2	-	5	871	c.749G>A	c.(748-750)gGg>gAg	p.G250E	OSBPL10_ENST00000438237.2_Missense_Mutation_p.G186E|OSBPL10_ENST00000467647.1_5'UTR	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	250					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		CTTCTGCTGCCCTTCCACCTG	0.567000													50	71					0	0	0.048971	0	0
MYLK2	85366	broad.mit.edu	37	20	30408011	30408011	+	Silent	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:30408011G>C	ENST00000375994.2	+	2	408	c.135G>C	c.(133-135)ccG>ccC	p.P45P	MYLK2_ENST00000375985.4_Silent_p.P45P			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	45					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGAAAGCTCCGGATCCACCCA	0.597000													31	20					0	0	0.054565	0	0
FAM49B	51571	broad.mit.edu	37	8	130874493	130874493	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:130874493C>G	ENST00000519824.2	-	5	556	c.283G>C	c.(283-285)Gaa>Caa	p.E95Q	FAM49B_ENST00000522250.1_5'UTR|FAM49B_ENST00000518879.1_5'UTR|FAM49B_ENST00000523509.1_Missense_Mutation_p.E95Q|FAM49B_ENST00000519110.1_Missense_Mutation_p.E95Q|FAM49B_ENST00000517654.1_Missense_Mutation_p.E95Q|FAM49B_ENST00000401979.2_Missense_Mutation_p.E95Q|FAM49B_ENST00000519540.1_Missense_Mutation_p.E95Q|FAM49B_ENST00000522941.1_Intron|FAM49B_ENST00000522746.1_Missense_Mutation_p.E95Q	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	95										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TGAGAAAATTCGTAAAATTTC	0.358000													117	171					0	0	0.048971	0	0
SCN3A	6328	broad.mit.edu	37	2	165948941	165948941	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:165948941T>A	ENST00000360093.3	-	27	5121	c.4630A>T	c.(4630-4632)Atg>Ttg	p.M1544L	SCN3A_ENST00000283254.7_Missense_Mutation_p.M1544L|SCN3A_ENST00000540861.1_Missense_Mutation_p.M27L|SCN3A_ENST00000465043.1_5'UTR|SCN3A_ENST00000409101.3_Missense_Mutation_p.M1495L	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1544						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GTTTCCACCATCATGGTGACC	0.423000													56	48					0	0	0.048971	0	0
GPC5	2262	broad.mit.edu	37	13	92345880	92345880	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:92345880G>T	ENST00000377067.3	+	3	1137	c.765G>T	c.(763-765)atG>atT	p.M255I		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	255						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCCTGAAGATGCAATACTGCC	0.552000													48	29					4.29476e-34	6.43264e-34	0.048971	1	0
CCDC108	255101	broad.mit.edu	37	2	219886523	219886523	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:219886523C>T	ENST00000341552.5	-	18	3192	c.3109G>A	c.(3109-3111)Gcc>Acc	p.A1037T	CCDC108_ENST00000453220.1_Missense_Mutation_p.A1037T|CCDC108_ENST00000441968.1_Missense_Mutation_p.A1037T	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1037						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGTCAACGGCCTCAGGGCTG	0.612000													24	19					0	0	0.080422	0	0
POLR3B	55703	broad.mit.edu	37	12	106895116	106895116	+	Silent	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:106895116A>G	ENST00000228347.4	+	26	3222	c.3000A>G	c.(2998-3000)gcA>gcG	p.A1000A	POLR3B_ENST00000539066.1_Silent_p.A942A|RP11-144F15.1_ENST00000551505.1_Intron	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	1000					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						CCTTAGAAGCATACATCTATT	0.498000													5	275					0	0	0.021553	0	0
SELE	6401	broad.mit.edu	37	1	169698684	169698684	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:169698684C>G	ENST00000333360.7	-	6	985	c.846G>C	c.(844-846)caG>caC	p.Q282H	SELE_ENST00000367777.1_Missense_Mutation_p.Q282H|SELE_ENST00000367776.1_Missense_Mutation_p.Q282H|SELE_ENST00000367775.1_Missense_Mutation_p.Q220H|SELE_ENST00000367779.4_Missense_Mutation_p.Q282H|SELE_ENST00000367782.4_Missense_Mutation_p.Q282H|SELE_ENST00000367774.1_Missense_Mutation_p.Q282H|SELE_ENST00000367781.4_Missense_Mutation_p.Q282H|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Missense_Mutation_p.Q220H	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	282	Sushi 2.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					ACTGAAGGCTCTGGGCTCCCA	0.458000													45	125					0	0	0.048971	0	0
LRP2	4036	broad.mit.edu	37	2	170063751	170063751	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:170063751T>C	ENST00000263816.3	-	39	6764	c.6479A>G	c.(6478-6480)tAt>tGt	p.Y2160C		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2160					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTGGTGAAATAAAGATTTCC	0.373000													53	44					0	0	0.048971	0	0
KIAA1586	57691	broad.mit.edu	37	6	56915638	56915638	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:56915638G>T	ENST00000370733.4	+	3	379	c.172G>T	c.(172-174)Gcc>Tcc	p.A58S	KIAA1586_ENST00000545356.1_Intron|KIAA1586_ENST00000488682.1_3'UTR	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	58							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAACCCTAGCGCCTATTATAG	0.383000													48	76					1.56241e-48	2.55496e-48	0.048971	1	0
JAK1	3716	broad.mit.edu	37	1	65330594	65330594	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:65330594T>C	ENST00000342505.4	-	8	1300	c.1052A>G	c.(1051-1053)aAg>aGg	p.K351R		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	351	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CTCATCCTTCTTGTGTTTATT	0.358000			Mis		ALL								67	107					0	0	0.048971	0	0
CP	1356	broad.mit.edu	37	3	148917570	148917570	+	Missense_Mutation	SNP	G	G	A	rs35331711	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:148917570G>A	ENST00000264613.6	-	8	1692	c.1430C>T	c.(1429-1431)cCg>cTg	p.P477L		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	477	F5/8 type A 2.|Plastocyanin-like 3.		P -> L (in dbSNP:rs35331711).		cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CACCCCAATCGGCTCAATACT	0.458000													72	111					0	0	0.048971	0	0
COL22A1	169044	broad.mit.edu	37	8	139614397	139614397	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:139614397G>A	ENST00000303045.6	-	60	4592	c.4146C>T	c.(4144-4146)gtC>gtT	p.V1382V	COL22A1_ENST00000435777.1_Silent_p.V1362V|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1382	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCTTCCCAGGGACCCCCTGCA	0.577000										HNSCC(7;0.00092)			35	74					0	0	0.086207	0	0
MDH1	4190	broad.mit.edu	37	2	63832432	63832432	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:63832432G>T	ENST00000233114.8	+	7	1129	c.694G>T	c.(694-696)Gct>Tct	p.A232S	MDH1_ENST00000394423.1_Missense_Mutation_p.A232S|MDH1_ENST00000544381.1_Missense_Mutation_p.A143S|MDH1_ENST00000409908.1_Missense_Mutation_p.A67S|MDH1_ENST00000539945.1_Missense_Mutation_p.A250S|MDH1_ENST00000409476.1_Missense_Mutation_p.A108S	NM_005917.3	NP_005908.1	P40925	MDHC_HUMAN	malate dehydrogenase 1, NAD (soluble)	232					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(4)	13					NADH(DB00157)	GCAGCGTGGCGCTGCTGTCAT	0.517000													15	31					1.3612e-06	1.46508e-06	0.024245	1	0
SYMPK	8189	broad.mit.edu	37	19	46345509	46345509	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:46345509C>A	ENST00000245934.7	-	9	1330	c.1087_splice	c.e9+1	p.L362_splice		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	362					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CCCTCTCACCCAGCTTCATCT	0.517000													112	112					8.80896e-55	1.49092e-54	0.048971	1	0
C12orf40	283461	broad.mit.edu	37	12	40076498	40076498	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:40076498G>A	ENST00000324616.5	+	8	926	c.772G>A	c.(772-774)Gac>Aac	p.D258N	C12orf40_ENST00000398716.1_Missense_Mutation_p.D181N|C12orf40_ENST00000405531.3_Missense_Mutation_p.D258N	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	258										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						AAGACAGTCAGACTACATTAC	0.353000													150	13					0	0	0.048971	0	0
CACNA2D1	781	broad.mit.edu	37	7	81603792	81603792	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:81603792T>C	ENST00000356860.3	-	25	2370	c.2032A>G	c.(2032-2034)Aaa>Gaa	p.K678E	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.K690E	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	690						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTTGGAGTTTTTCTATCAATA	0.284000													21	19					0	0	0.069288	0	0
GPA33	10223	broad.mit.edu	37	1	167038196	167038196	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:167038196C>T	ENST00000367868.3	-	3	721	c.378G>A	c.(376-378)gaG>gaA	p.E126E	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	126	Ig-like V-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						TGGTGTTGCCCTCCAGGTCTG	0.562000													40	59					0	0	0.111260	0	0
SPTBN1	6711	broad.mit.edu	37	2	54844783	54844783	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:54844783G>T	ENST00000333896.5	+	5	951	c.566G>T	c.(565-567)tGg>tTg	p.W189L	SPTBN1_ENST00000356805.4_Missense_Mutation_p.W202L	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	202	Actin-binding.|CH 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			ACCACTAGCTGGAGGGACGGC	0.453000													51	31					2.44813e-32	3.5952e-32	0.048971	1	0
NAALAD2	10003	broad.mit.edu	37	11	89885637	89885637	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:89885637G>T	ENST00000534061.1	+	6	1011	c.781G>T	c.(781-783)Ggc>Tgc	p.G261C	NAALAD2_ENST00000375944.3_Missense_Mutation_p.G261C|NAALAD2_ENST00000525171.1_Missense_Mutation_p.G261C|NAALAD2_ENST00000321955.4_Missense_Mutation_p.G261C	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	261					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ACTCACTCCAGGCTATCCAGC	0.448000													67	60					1.25742e-37	1.93471e-37	0.048971	1	0
ANKRD24	170961	broad.mit.edu	37	19	4210294	4210294	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:4210294G>T	ENST00000600132.1	+	13	1260	c.984G>T	c.(982-984)agG>agT	p.R328S	ANKRD24_ENST00000262970.5_Missense_Mutation_p.R418S|ANKRD24_ENST00000318934.4_Missense_Mutation_p.R328S|ANKRD24_ENST00000595096.1_3'UTR	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	328										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		AGATCGTGAGGCTGCGGCAGG	0.627000													14	19					2.4624e-09	2.77378e-09	0.049695	1	0
ZNF425	155054	broad.mit.edu	37	7	148801676	148801676	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:148801676C>T	ENST00000378061.2	-	4	1419	c.1287G>A	c.(1285-1287)ctG>ctA	p.L429L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	429					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGTGGGCTTTCAGGCTTCTCT	0.587000													87	83					0	0	0.048971	0	0
RFX6	222546	broad.mit.edu	37	6	117246757	117246757	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:117246757C>A	ENST00000332958.2	+	16	1836	c.1820C>A	c.(1819-1821)cCt>cAt	p.P607H		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	607					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TCCAGTCAACCTGGAGGCCTA	0.542000													43	69					2.56175e-15	3.17638e-15	0.048971	1	0
HYDIN	54768	broad.mit.edu	37	16	71007911	71007911	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:71007911G>C	ENST00000393567.2	-	34	5200	c.5050C>G	c.(5050-5052)Cca>Gca	p.P1684A		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1684										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGAACTGTTGGCCCTCCAACC	0.478000													11	48					0	0	0.043863	0	0
NOVA2	4858	broad.mit.edu	37	19	46443836	46443836	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:46443836G>T	ENST00000263257.5	-	4	958	c.764C>A	c.(763-765)cCc>cAc	p.P255H		NM_002516.2	NP_002507.1	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	255	Ala-rich.					nucleus	RNA binding			endometrium(3)|large_intestine(5)|lung(13)	21		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		CAGCCCGGCGGGGCCCAGCAG	0.756000													2	3					0.00307968	0.00316861	0.038147	1	0
MAGEL2	54551	broad.mit.edu	37	15	23890368	23890368	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:23890368T>A	ENST00000532292.1	-	1	807	c.713A>T	c.(712-714)aAt>aTt	p.N238I		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGCATTCATATTGGGCTGTGG	0.592000													36	65					0	0	0.092188	0	0
CSMD1	64478	broad.mit.edu	37	8	3205673	3205673	+	Silent	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:3205673T>A	ENST00000520002.1	-	23	3873	c.3318A>T	c.(3316-3318)ggA>ggT	p.G1106G	CSMD1_ENST00000602723.1_Silent_p.G1106G|CSMD1_ENST00000400186.3_Silent_p.G1106G|CSMD1_ENST00000602557.1_Silent_p.G1106G|CSMD1_ENST00000542608.1_Silent_p.G1105G|CSMD1_ENST00000539096.1_Silent_p.G1105G|CSMD1_ENST00000537824.1_Silent_p.G1105G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1106	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGACACTTGCTCCACATTCGG	0.333000													19	24					0	0	0.062417	0	0
CHML	1122	broad.mit.edu	37	1	241798259	241798259	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:241798259T>A	ENST00000366553.1	-	1	973	c.810A>T	c.(808-810)gaA>gaT	p.E270D	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000469376.1_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	270					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTACCTTTCCTTCCCGAAATG	0.348000													37	59					0	0	0.074837	0	0
MLLT10	8028	broad.mit.edu	37	10	21962822	21962822	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:21962822G>T	ENST00000377072.3	+	11	1943	c.1595G>T	c.(1594-1596)aGt>aTt	p.S532I	MLLT10_ENST00000446906.2_Missense_Mutation_p.S532I|MLLT10_ENST00000377059.3_Missense_Mutation_p.S532I|MLLT10_ENST00000307729.7_Missense_Mutation_p.S532I	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	532	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						CAGAGCCTCAGTGTTGGCTCA	0.453000			T	"""MLL, PICALM, CDK6"""	AL								59	90					5.00936e-31	7.26196e-31	0.048971	1	0
EYS	346007	broad.mit.edu	37	6	66204803	66204803	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:66204803C>A	ENST00000503581.1	-	4	1038	c.501G>T	c.(499-501)gtG>gtT	p.V167V	EYS_ENST00000370616.2_Silent_p.V167V|EYS_ENST00000370618.3_Silent_p.V167V|EYS_ENST00000342421.5_Silent_p.V167V|EYS_ENST00000370621.3_Silent_p.V167V|EYS_ENST00000393380.2_Silent_p.V167V	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	167					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GTTTCACTGTCACATTTAGTC	0.433000													59	68					6.20203e-27	8.71116e-27	0.048971	1	0
NFASC	23114	broad.mit.edu	37	1	204985663	204985663	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:204985663C>A	ENST00000367172.4	+	32	4368	c.4040C>A	c.(4039-4041)gCc>gAc	p.A1347D	NFASC_ENST00000338515.6_Missense_Mutation_p.A1257D|NFASC_ENST00000367169.4_Missense_Mutation_p.A1071D|NFASC_ENST00000513543.1_Missense_Mutation_p.A1169D|NFASC_ENST00000401399.1_Missense_Mutation_p.A1240D|NFASC_ENST00000339876.6_Missense_Mutation_p.A1240D|NFASC_ENST00000338586.6_Missense_Mutation_p.A1224D|NFASC_ENST00000360049.4_Missense_Mutation_p.A1169D|NFASC_ENST00000404076.1_Missense_Mutation_p.A1157D|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000367170.4_Missense_Mutation_p.A1268D|NFASC_ENST00000404907.1_Missense_Mutation_p.A1174D|NFASC_ENST00000367171.4_Missense_Mutation_p.A1332D|NFASC_ENST00000539706.1_Missense_Mutation_p.A1174D			O94856	NFASC_HUMAN	neurofascin	1347					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TACTCTCTGGCCTAACGGAGC	0.567000													46	55					1.66251e-12	1.95063e-12	0.048971	1	0
PLBD2	196463	broad.mit.edu	37	12	113824843	113824843	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:113824843G>T	ENST00000280800.3	+	10	1419	c.1388G>T	c.(1387-1389)cGg>cTg	p.R463L	PLBD2_ENST00000545182.2_Missense_Mutation_p.R431L	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	463					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CAGATCTTCCGGCGGAACCAG	0.602000													72	98					1.53276e-45	2.45895e-45	0.048971	1	0
TRHDE	29953	broad.mit.edu	37	12	72936124	72936124	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:72936124G>T	ENST00000261180.4	+	7	1737	c.1641G>T	c.(1639-1641)caG>caT	p.Q547H		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	547					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CAGTTTTCCAGAGGGGTTTGC	0.308000													33	57					6.19805e-25	8.56343e-25	0.080422	1	0
CACNA1B	774	broad.mit.edu	37	9	141010115	141010115	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:141010115A>T	ENST00000277549.5	+	42	5912	c.3343A>T	c.(3343-3345)Agc>Tgc	p.S1115C	CACNA1B_ENST00000371363.1_Missense_Mutation_p.S1919C|CACNA1B_ENST00000371372.1_Missense_Mutation_p.S1921C|CACNA1B_ENST00000277551.2_Missense_Mutation_p.S1921C|CACNA1B_ENST00000371355.4_Missense_Mutation_p.S1922C|CACNA1B_ENST00000371357.1_Missense_Mutation_p.S1920C			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1921					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CACCTCCCTCAGCAATGGCGG	0.582000													36	38					0	0	0.111260	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432991	140432991	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140432991C>G	ENST00000306549.3	+	1	2013	c.1936C>G	c.(1936-1938)Cag>Gag	p.Q646E		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		646	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTCTTGTTCAGGATCACGG	0.448000													63	100					0	0	0.048971	0	0
EFHC2	80258	broad.mit.edu	37	X	44109566	44109566	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:44109566T>C	ENST00000420999.1	-	5	815	c.732A>G	c.(730-732)ggA>ggG	p.G244G		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	244	DM10 2.						calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						CTCTACGGTCTCCAAACATTG	0.443000													23	2					0	0	0.091800	0	0
MOCS1	4337	broad.mit.edu	37	6	39883915	39883915	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:39883915C>A	ENST00000373186.4	-	3	617	c.480G>T	c.(478-480)ctG>ctT	p.L160L	MOCS1_ENST00000432280.2_Silent_p.L131L|MOCS1_ENST00000373195.3_Silent_p.L73L|MOCS1_ENST00000373175.4_Silent_p.L131L|MOCS1_ENST00000308559.7_Silent_p.L160L|MOCS1_ENST00000425303.2_Silent_p.L160L|MOCS1_ENST00000340692.5_Silent_p.L160L|MOCS1_ENST00000373188.2_Silent_p.L160L	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	160	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GTAGCCGGGCCAGGTTGATGC	0.572000													6	8					3.59834e-05	3.77101e-05	0.021553	1	0
ATAD3C	219293	broad.mit.edu	37	1	1391282	1391282	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:1391282A>G	ENST00000378785.2	+	6	1545	c.550A>G	c.(550-552)Acg>Gcg	p.T184A		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	184							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CACCGGGAAGACGCTGTTTGC	0.637000													6	14					0	0	0.029380	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572514	140572514	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140572514C>A	ENST00000239446.4	+	1	573	c.389C>A	c.(388-390)gCg>gAg	p.A130E		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		130	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.A130V(1)		breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGATCACGCGCCAGTATTT	0.423000													61	126					6.86016e-32	1.00309e-31	0.048971	1	0
CC2D2A	57545	broad.mit.edu	37	4	15591208	15591208	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:15591208A>C	ENST00000424120.1	+	33	4474	c.4220A>C	c.(4219-4221)tAt>tCt	p.Y1407S	CC2D2A_ENST00000413206.1_Missense_Mutation_p.Y1407S|CC2D2A_ENST00000389652.5_Missense_Mutation_p.Y1299S|CC2D2A_ENST00000503292.1_Missense_Mutation_p.Y1407S			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	1407					cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						CAAGGTCGTTATTTAATATGG	0.388000													125	110					0	0	0.048971	0	0
RYR2	6262	broad.mit.edu	37	1	237711738	237711738	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:237711738C>G	ENST00000366574.2	+	26	3231	c.2914C>G	c.(2914-2916)Ctg>Gtg	p.L972V	RYR2_ENST00000542537.1_Missense_Mutation_p.L956V|RYR2_ENST00000360064.6_Missense_Mutation_p.L970V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	972	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAGTTACCAGCTGACAAGTGG	0.398000													16	22					0	0	0.043863	0	0
FEZ1	9638	broad.mit.edu	37	11	125330404	125330404	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:125330404C>A	ENST00000278919.3	-	5	891	c.657G>T	c.(655-657)tgG>tgT	p.W219C	FEZ1_ENST00000527350.1_Intron	NM_005103.4	NP_005094.1	Q99689	FEZ1_HUMAN	fasciculation and elongation protein zeta 1 (zygin I)	219					axon guidance|cell adhesion|transport	microtubule|plasma membrane				breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	24	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		CTTCATAGGACCAGTTGTTGT	0.577000													71	66					1.37693e-34	2.06693e-34	0.048971	1	0
MUC16	94025	broad.mit.edu	37	19	9085589	9085589	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:9085589C>A	ENST00000397910.4	-	1	6429	c.6226G>T	c.(6226-6228)Ggc>Tgc	p.G2076C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2076	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGAATGGCCTGAGGACAGT	0.468000													304	438					5.2272e-135	9.48744e-135	0.048971	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144852366	144852366	+	Silent	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:144852366T>A	ENST00000369356.4	-	44	7367	c.7077A>T	c.(7075-7077)ctA>ctT	p.L2359L	PDE4DIP_ENST00000530740.1_3'UTR|PDE4DIP_ENST00000369359.4_3'UTR|PDE4DIP_ENST00000313382.9_3'UTR|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_3'UTR	NM_001198834.2|NM_014644.4	NP_001185763.2|NP_055459.4	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGCAGATAGGTAGCTGCACAA	0.567000			T	PDGFRB	MPD								6	31					0	0	0.080935	0	0
HMGA2	8091	broad.mit.edu	37	12	66232336	66232336	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:66232336G>C	ENST00000541363.1	+	3	609	c.236G>C	c.(235-237)aGa>aCa	p.R79T	HMGA2_ENST00000354636.3_Missense_Mutation_p.R79T|HMGA2_ENST00000393578.3_Missense_Mutation_p.R79T|HMGA2_ENST00000393577.3_Missense_Mutation_p.R79T|HMGA2_ENST00000536545.1_Missense_Mutation_p.R79T|HMGA2_ENST00000403681.2_Missense_Mutation_p.R79T|HMGA2_ENST00000425208.2_Missense_Mutation_p.R79T			P52926	HMGA2_HUMAN	high mobility group AT-hook 2	79					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/RAD51B(11)|HMGA2/CCNB1IP1(2)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/LPP(161)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/COX6C(2)	lung(2)	2	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		CCAAGAGGCAGACCTAGGAAA	0.323000			T	""" LHFP, RAD51L1, LPP, COX6C, CMKOR1, NFIB, ALDH2, CCNB1IP1, EBF1, WIF1, FHIT"""	"""lipoma, leiomyoma, pleiomorphic salivary gland adenoma"""								25	49					0	0	0.092188	0	0
LDLR	3949	broad.mit.edu	37	19	11213428	11213428	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:11213428G>A	ENST00000558518.1	+	3	466	c.279G>A	c.(277-279)gtG>gtA	p.V93V	LDLR_ENST00000455727.2_Silent_p.V93V|LDLR_ENST00000535915.1_Intron|LDLR_ENST00000558013.1_Silent_p.V93V|LDLR_ENST00000557933.1_Silent_p.V93V|LDLR_ENST00000545707.1_Silent_p.V93V	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	93	LDL-receptor class A 2.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	ATGGCCAAGTGGACTGCGACA	0.567000													99	106					0	0	0.048971	0	0
POTEM	641455	broad.mit.edu	37	14	20019987	20019987	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:20019987G>T	ENST00000551509.1	-	1	285	c.234C>A	c.(232-234)agC>agA	p.S78R		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	78										endometrium(4)|kidney(1)|lung(4)	9						TGCCCACGTTGCTCTTGCCGC	0.592000													24	330					2.69953e-25	3.73739e-25	0.048971	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47115536	47115536	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:47115536C>T	ENST00000290341.3	+	6	742	c.408C>T	c.(406-408)atC>atT	p.I136I	IGF2BP1_ENST00000431824.2_Intron	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	136	RRM 2.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CCAGAGCCATCATGAAGCTGA	0.532000													111	187					0	0	0.048971	0	0
CD177	57126	broad.mit.edu	37	19	43859867	43859867	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:43859867G>T	ENST00000378009.4	+	0	476				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				TGTCTGGAGGGGACAACAGAA	0.592000													63	77					6.00099e-30	8.68091e-30	0.048971	1	0
CDH22	64405	broad.mit.edu	37	20	44856177	44856177	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:44856177C>A	ENST00000372262.3	-	3	1040	c.640G>T	c.(640-642)Gag>Tag	p.E214*	CDH22_ENST00000537909.1_Nonsense_Mutation_p.E214*	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	214	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				AAGTGGTGCTCGCCGTCCAGC	0.736000													28	24					3.99451e-17	5.08324e-17	0.041601	1	0
CDHR2	54825	broad.mit.edu	37	5	175995737	175995737	+	Silent	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:175995737G>C	ENST00000510636.1	+	4	457	c.183G>C	c.(181-183)ggG>ggC	p.G61G	CDHR2_ENST00000506348.1_Silent_p.G61G|CDHR2_ENST00000261944.5_Silent_p.G61G	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	61	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding	p.G61G(1)		breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TGACCTATGGGATGAGCGGCC	0.607000													31	46					0	0	0.041601	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768280	31768280	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:31768280G>T	ENST00000240587.4	-	2	2746	c.2419C>A	c.(2419-2421)Ctt>Att	p.L807I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	807					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGTGACAGAAGCACTGAACCC	0.552000													51	56					8.44121e-28	1.20309e-27	0.048971	1	0
FBXO47	494188	broad.mit.edu	37	17	37101330	37101330	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:37101330G>T	ENST00000378079.2	-	7	875	c.676C>A	c.(676-678)Cat>Aat	p.H226N		NM_001008777.2	NP_001008777.2	Q5MNV8	FBX47_HUMAN	F-box protein 47	226										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	20						TGTGTCCAATGATCAAGGAGG	0.393000													28	135					6.07407e-21	8.03154e-21	0.034045	1	0
GLI1	2735	broad.mit.edu	37	12	57858626	57858626	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:57858626G>T	ENST00000228682.2	+	4	455	c.364G>T	c.(364-366)Ggt>Tgt	p.G122C	GLI1_ENST00000546141.1_Missense_Mutation_p.G81C|GLI1_ENST00000543426.1_5'UTR	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	122					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			AGGCTCCTACGGTCATCTCTC	0.577000													85	177					5.93652e-64	1.03317e-63	0.048971	1	0
FSHR	2492	broad.mit.edu	37	2	49190382	49190382	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:49190382C>G	ENST00000406846.2	-	10	1697	c.1578G>C	c.(1576-1578)ttG>ttC	p.L526F	FSHR_ENST00000304421.4_Missense_Mutation_p.L500F|FSHR_ENST00000541117.1_Missense_Mutation_p.L262F|FSHR_ENST00000346173.3_Missense_Mutation_p.L464F	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	526					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ACAGCTGTGACAAAGGGCTGT	0.512000									Gonadal Dysgenesis, 46 XX				35	40					0	0	0.069456	0	0
RBM12	10137	broad.mit.edu	37	20	34240756	34240756	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:34240756C>A	ENST00000374114.3	-	3	2752	c.2489G>T	c.(2488-2490)gGc>gTc	p.G830V	RBM12_ENST00000359646.1_Missense_Mutation_p.G830V|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000317677.5_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397443.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.G830V|CPNE1_ENST00000317619.3_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	830	Gly-rich.|Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			ggggccggggccggggccagg	0.612000													17	14					6.94344e-10	7.90035e-10	0.038395	1	0
TLL1	7092	broad.mit.edu	37	4	166986903	166986903	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:166986903C>T	ENST00000061240.2	+	16	2723	c.2076C>T	c.(2074-2076)ttC>ttT	p.F692F	TLL1_ENST00000507499.1_Silent_p.F715F	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	692	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.F692F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATGGCAAATTCTGTGGCGCTG	0.403000													65	97					0	0	0.048971	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184440	130184440	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:130184440T>C	ENST00000422113.2	-	2	1209	c.883A>G	c.(883-885)Ata>Gta	p.I295V		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	295						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTCTTTGGTATATAGTGGATG	0.512000													13	37					0	0	0.062417	0	0
GSAP	54103	broad.mit.edu	37	7	76984659	76984659	+	Silent	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:76984659G>C	ENST00000257626.7	-	16	1287	c.1209C>G	c.(1207-1209)ctC>ctG	p.L403L		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		GTGCTCTATAGAGCTTTCCAG	0.453000													90	155					0	0	0.048971	0	0
FAM208A	23272	broad.mit.edu	37	3	56683054	56683054	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:56683054T>A	ENST00000431842.2	-	5	1136	c.212A>T	c.(211-213)tAc>tTc	p.Y71F	FAM208A_ENST00000493960.2_Missense_Mutation_p.Y467F|FAM208A_ENST00000355628.5_Missense_Mutation_p.Y467F	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	467										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						AAGAAAAAGGTATCCTCGGTC	0.363000													29	45					0	0	0.039052	0	0
RB1	5925	broad.mit.edu	37	13	48916851	48916851	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:48916851G>T	ENST00000267163.4	+	3	518		c.e3+1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(9)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGAAATCAGGTAAAGTTTCT	0.343000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			44	18					1.8453e-21	2.46404e-21	0.039052	1	0
TSPAN12	23554	broad.mit.edu	37	7	120446688	120446688	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:120446688C>A	ENST00000222747.3	-	7	1134	c.527G>T	c.(526-528)tGg>tTg	p.W176L	TSPAN12_ENST00000415871.1_Missense_Mutation_p.W176L	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	176					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					ATCTGGGGGCCAGTCCATCTC	0.443000													53	63					8.52529e-16	1.07279e-15	0.048971	1	0
TACC2	10579	broad.mit.edu	37	10	123846990	123846990	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:123846990G>T	ENST00000369005.1	+	4	5315	c.4975G>T	c.(4975-4977)Gaa>Taa	p.E1659*	TACC2_ENST00000515603.1_Nonsense_Mutation_p.E1659*|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Nonsense_Mutation_p.E1659*|TACC2_ENST00000515273.1_Nonsense_Mutation_p.E1659*|TACC2_ENST00000453444.2_Nonsense_Mutation_p.E1659*|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1659						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCTTGGGGGTGAAAGGAGACC	0.592000													32	41					3.90053e-15	4.82753e-15	0.050027	1	0
MYH10	4628	broad.mit.edu	37	17	8393742	8393742	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:8393742C>A	ENST00000360416.3	-	35	4938	c.4800G>T	c.(4798-4800)atG>atT	p.M1600I	MYH10_ENST00000269243.4_Missense_Mutation_p.M1569I|MYH10_ENST00000396239.1_Missense_Mutation_p.M1590I|MYH10_ENST00000379980.4_Missense_Mutation_p.M1585I	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1569					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCATGGCCTGCATGTTGACCT	0.572000													136	175					2.94116e-64	5.13187e-64	0.048971	1	0
RYR3	6263	broad.mit.edu	37	15	33842510	33842510	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:33842510C>A	ENST00000389232.4	+	10	1035	c.965C>A	c.(964-966)gCa>gAa	p.A322E	RYR3_ENST00000415757.3_Missense_Mutation_p.A322E	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	322	MIR 4.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTTTCCGGGCATCAAAGGTA	0.478000													22	16					1.9806e-07	2.15227e-07	0.069288	1	0
CSMD1	64478	broad.mit.edu	37	8	3432588	3432588	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:3432588G>T	ENST00000520002.1	-	11	1781	c.1225_splice	c.e11-1	p.A409_splice	CSMD1_ENST00000602723.1_Splice_Site_p.A409_splice|CSMD1_ENST00000400186.3_Splice_Site_p.A409_splice|CSMD1_ENST00000602557.1_Splice_Site_p.A409_splice|CSMD1_ENST00000542608.1_Splice_Site_p.A408_splice|CSMD1_ENST00000539096.1_Splice_Site_p.A408_splice|CSMD1_ENST00000537824.1_Splice_Site_p.A408_splice			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	409	Sushi 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACATGTTCTCGCTGGAAACAC	0.413000													31	50					3.86903e-22	5.21779e-22	0.054565	1	0
MTR	4548	broad.mit.edu	37	1	237058851	237058851	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:237058851G>T	ENST00000366577.5	+	31	3992		c.e31+1		MTR_ENST00000535889.1_Splice_Site|MTR_ENST00000470570.1_Splice_Site	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CAGTCTACAGGTAGGAGCCAG	0.547000													5	5					3.59834e-05	3.77101e-05	0.021553	1	0
HYDIN	54768	broad.mit.edu	37	16	70926379	70926379	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:70926379G>A	ENST00000393567.2	-	56	9452	c.9302C>T	c.(9301-9303)tCa>tTa	p.S3101L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3101										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGGTTGGACTGAGATCATGGA	0.428000													38	156					0	0	0.048971	0	0
HTR3C	170572	broad.mit.edu	37	3	183777831	183777831	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:183777831G>T	ENST00000318351.1	+	8	1175	c.1141_splice	c.e8+1	p.G381_splice		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	381						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCACCTGCCTGGTGAGGGAAG	0.617000													4	11					0.000157383	0.000164427	0.038147	1	0
TLR2	7097	broad.mit.edu	37	4	154626008	154626008	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:154626008G>T	ENST00000260010.6	+	1	3357	c.1949G>T	c.(1948-1950)cGg>cTg	p.R650L		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	650	TIR.				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TACAGTGAGCGGGATGCCTAC	0.502000													33	56					1.04352e-10	1.20556e-10	0.064281	1	0
TMEM131	23505	broad.mit.edu	37	2	98378537	98378537	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:98378537C>A	ENST00000186436.5	-	36	5078	c.4850G>T	c.(4849-4851)cGg>cTg	p.R1617L		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1617						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GTAGCTGCCCCGGGCCACAAA	0.577000													29	20					2.80507e-11	3.26856e-11	0.050027	1	0
CHL1	10752	broad.mit.edu	37	3	419556	419556	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:419556G>A	ENST00000256509.2	+	16	2449	c.1807G>A	c.(1807-1809)Ggt>Agt	p.G603S	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.G587S	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	587	Ig-like C2-type 6.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGAGGACCAAGGTATTTACTG	0.358000													98	134					0	0	0.048971	0	0
LHCGR	3973	broad.mit.edu	37	2	48921418	48921418	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:48921418C>T	ENST00000294954.7	-	10	913	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Intron|LHCGR_ENST00000401907.1_Missense_Mutation_p.E298K|LHCGR_ENST00000344775.3_Missense_Mutation_p.E236K|LHCGR_ENST00000403273.1_Missense_Mutation_p.E298K	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	298					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GAAAAGTTTTCAGAAATGGAA	0.353000													22	39					0	0	0.069288	0	0
SLC27A6	28965	broad.mit.edu	37	5	128368829	128368829	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:128368829C>G	ENST00000262462.4	+	10	2724	c.1714C>G	c.(1714-1716)Cta>Gta	p.L572V	SLC27A6_ENST00000506176.1_Missense_Mutation_p.L572V|SLC27A6_ENST00000395266.1_Missense_Mutation_p.L572V			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	572					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AACATTCAAACTATTGAAGCA	0.303000													16	24					0	0	0.038395	0	0
MAP3K5	4217	broad.mit.edu	37	6	136926374	136926374	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:136926374C>A	ENST00000359015.4	-	19	3012	c.2652G>T	c.(2650-2652)ctG>ctT	p.L884L	MAP3K5_ENST00000355845.4_Silent_p.L131L	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	884	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GTGGTTCTCCCAGTTCATAAA	0.418000													89	150					3.33393e-45	5.33586e-45	0.048971	1	0
UNC45B	146862	broad.mit.edu	37	17	33495200	33495200	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:33495200G>T	ENST00000268876.5	+	10	1369	c.1272G>T	c.(1270-1272)gaG>gaT	p.E424D	UNC45B_ENST00000378449.1_Missense_Mutation_p.E424D|UNC45B_ENST00000433649.1_Missense_Mutation_p.E424D|UNC45B_ENST00000394570.2_Missense_Mutation_p.E424D|UNC45B_ENST00000591048.1_Missense_Mutation_p.E424D	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	424					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				GTGTGATGGAGATGATGGTGG	0.597000													24	43					1.55469e-16	1.96001e-16	0.083992	1	0
CACNA1D	776	broad.mit.edu	37	3	53804040	53804040	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:53804040C>T	ENST00000288139.3	+	32	4089	c.3971C>T	c.(3970-3972)cCt>cTt	p.P1324L	CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1304L|CACNA1D_ENST00000422281.2_Intron|CACNA1D_ENST00000540742.1_Intron	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1304					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACTGCTACACCTGGGGTAAGA	0.428000													93	159					0	0	0.048971	0	0
LZTR1	8216	broad.mit.edu	37	22	21340155	21340155	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:21340155C>T	ENST00000215739.8	+	3	648	c.289C>T	c.(289-291)Cgg>Tgg	p.R97W	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Intron	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	97					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGACCTCCTGCGGTTCGATGT	0.602000													21	2					0	0	0.062417	0	0
DDX54	79039	broad.mit.edu	37	12	113603731	113603731	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:113603731G>A	ENST00000314045.7	-	13	1548	c.1521C>T	c.(1519-1521)ggC>ggT	p.G507G	DDX54_ENST00000306014.5_Silent_p.G507G	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	507					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CGCGGGCCAGGCCCCGTAGCT	0.657000													19	55					0	0	0.055883	0	0
FUT3	2525	broad.mit.edu	37	19	5844847	5844847	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:5844847C>G	ENST00000303225.6	-	3	638	c.4G>C	c.(4-6)Gat>Cat	p.D2H	FUT3_ENST00000458379.2_Missense_Mutation_p.D2H|FUT3_ENST00000589620.1_Missense_Mutation_p.D2H|FUT3_ENST00000589918.1_Missense_Mutation_p.D2H	NM_000149.3	NP_000140.1	P21217	FUT3_HUMAN	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	2					protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						CCCAGGGGATCCATGGGTCAG	0.577000													45	62					0	0	0.104719	0	0
LNPEP	4012	broad.mit.edu	37	5	96315554	96315554	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:96315554C>T	ENST00000231368.5	+	2	1424	c.732C>T	c.(730-732)gcC>gcT	p.A244A	LNPEP_ENST00000395770.3_Silent_p.A230A	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	244					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GACAGATCGCCATTGTTGCCC	0.413000													79	97					0	0	0.048971	0	0
NDST4	64579	broad.mit.edu	37	4	115997337	115997337	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:115997337C>T	ENST00000264363.2	-	2	1534	c.856G>A	c.(856-858)Gat>Aat	p.D286N		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	286	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity	p.D286H(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GAGATGGCATCTATGAAGATG	0.443000													115	208					0	0	0.048971	0	0
CDH23	64072	broad.mit.edu	37	10	73550964	73550964	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:73550964T>A	ENST00000224721.6	+	46	6145	c.6140T>A	c.(6139-6141)cTg>cAg	p.L2047Q		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2042	Cadherin 19.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CTGCTGCTGCTGGCTGAGGAC	0.632000													9	10					0	0	0.080935	0	0
SULF1	23213	broad.mit.edu	37	8	70533314	70533314	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:70533314C>G	ENST00000260128.4	+	14	2139	c.1422C>G	c.(1420-1422)caC>caG	p.H474Q	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000419716.3_Missense_Mutation_p.H474Q|SULF1_ENST00000402687.4_Missense_Mutation_p.H474Q|SULF1_ENST00000458141.2_Missense_Mutation_p.H474Q	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	474					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTCGAATTCACAAGTGTAAAG	0.493000													46	59					0	0	0.048971	0	0
SPATA31A2	642265	broad.mit.edu	37	9	39887061	39887061	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:39887061G>T	ENST00000456183.2	+	3	332	c.303G>T	c.(301-303)ctG>ctT	p.L101L		NM_001040065.1	NP_001035154.1			SPATA31 subfamily A, member 2																		TTTCACAACTGCAGAGGTGAG	0.632000													104	152					1.78676e-68	3.12568e-68	0.048971	1	0
PRKCD	5580	broad.mit.edu	37	3	53221364	53221364	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:53221364C>T	ENST00000394729.2	+	14	1689	c.1361C>T	c.(1360-1362)gCc>gTc	p.A454V	PRKCD_ENST00000330452.3_Missense_Mutation_p.A454V	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	454	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AGGTTTTATGCCGCTGAGATA	0.587000													4	158					0	0	0.009096	0	0
TG	7038	broad.mit.edu	37	8	133900711	133900711	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:133900711A>G	ENST00000220616.4	+	10	2699	c.2659A>G	c.(2659-2661)Agc>Ggc	p.S887G	TG_ENST00000377869.1_Missense_Mutation_p.S887G	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	887	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTCAGACTTCAGCACTCCTTT	0.552000													39	40					0	0	0.104719	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433528	73433528	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:73433528T>C	ENST00000263666.4	-	10	2303	c.2189A>G	c.(2188-2190)aAc>aGc	p.N730S	PDZRN3_ENST00000479530.1_Missense_Mutation_p.N447S|PDZRN3_ENST00000462146.2_Missense_Mutation_p.N387S|PDZRN3_ENST00000466780.1_Missense_Mutation_p.N387S|PDZRN3_ENST00000535920.1_Missense_Mutation_p.N452S	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	730							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GATGCTGGTGTTGTAGTTGCG	0.602000													9	9					0	0	0.043863	0	0
PRDM9	56979	broad.mit.edu	37	5	23527761	23527761	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:23527761C>A	ENST00000296682.3	+	11	2746	c.2564C>A	c.(2563-2565)aCa>aAa	p.T855K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	855					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.T855K(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGGACACACACAGGGGAGAAG	0.592000										HNSCC(3;0.000094)			89	177					6.65942e-36	1.01086e-35	0.048971	1	0
LRIG2	9860	broad.mit.edu	37	1	113661947	113661947	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:113661947G>T	ENST00000361127.4	+	17	2971	c.2773G>T	c.(2773-2775)Gct>Tct	p.A925S	LRIG2_ENST00000492207.1_3'UTR	NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	925						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CACCTATATTGCTGAGGAGGA	0.468000													72	99					1.88737e-50	3.10887e-50	0.048971	1	0
AVPR1A	552	broad.mit.edu	37	12	63544125	63544125	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:63544125C>T	ENST00000299178.2	-	1	597	c.492G>A	c.(490-492)gcG>gcA	p.A164A		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	164					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GCGAGCGGCGCGCGGGCTGTT	0.617000													53	81					0	0	0.048971	0	0
TDRD3	81550	broad.mit.edu	37	13	61083927	61083927	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:61083927G>A	ENST00000196169.3	+	9	1398	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	TDRD3_ENST00000535286.1_Missense_Mutation_p.E297K|TDRD3_ENST00000377881.2_Missense_Mutation_p.E204K|TDRD3_ENST00000377894.2_Missense_Mutation_p.E204K	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	204	UBA.				chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity	p.E204*(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GCACATAACGGAAATGGGCTT	0.413000													94	141					0	0	0.048971	0	0
COLGALT1	79709	broad.mit.edu	37	19	17691563	17691563	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:17691563G>T	ENST00000252599.4	+	11	1570	c.1450G>T	c.(1450-1452)Gtg>Ttg	p.V484L		NM_024656.2	NP_078932.2			collagen beta(1-O)galactosyltransferase 1																		TGTGCCTCGCGTGAGGAACCT	0.652000													91	83					2.24395e-52	3.71432e-52	0.048971	1	0
IRAK2	3656	broad.mit.edu	37	3	10242074	10242074	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:10242074G>T	ENST00000256458.4	+	3	389	c.299G>T	c.(298-300)aGg>aTg	p.R100M		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	100					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						CCTGAAATCAGGTGTCCCATT	0.493000													139	193					4.74804e-72	8.3709e-72	0.048971	1	0
AHCYL2	23382	broad.mit.edu	37	7	129064950	129064950	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:129064950A>T	ENST00000325006.3	+	15	1730	c.1676A>T	c.(1675-1677)aAg>aTg	p.K559M	AHCYL2_ENST00000531335.2_Missense_Mutation_p.K478M|AHCYL2_ENST00000446544.2_Missense_Mutation_p.K558M|AHCYL2_ENST00000446212.1_Missense_Mutation_p.K457M|AHCYL2_ENST00000474594.1_Missense_Mutation_p.K456M|AHCYL2_ENST00000490911.1_Missense_Mutation_p.K456M	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	559					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GGTCGCTATAAGCAGGATGTC	0.448000													144	162					0	0	0.048971	0	0
WDR55	54853	broad.mit.edu	37	5	140048960	140048960	+	Silent	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140048960C>G	ENST00000358337.5	+	7	1110	c.873C>G	c.(871-873)ggC>ggG	p.G291G	WDR55_ENST00000520764.1_3'UTR	NM_017706.4	NP_060176.2	Q9H6Y2	WDR55_HUMAN	WD repeat domain 55	291					rRNA processing	cytoplasm|nucleolus				NS(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTGTGGGCCAGCACACTG	0.617000													9	43					0	0	0.080935	0	0
PMM1	5372	broad.mit.edu	37	22	41974850	41974850	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:41974850C>T	ENST00000216259.7	-	6	594	c.510G>A	c.(508-510)ctG>ctA	p.L170L		NM_002676.2	NP_002667.2	Q92871	PMM1_HUMAN	phosphomannomutase 1	170					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			NS(1)|large_intestine(4)|lung(3)|ovary(1)|urinary_tract(2)	11						ACTCTGTTTTCAGGGCTTCCA	0.607000													7	1					0	0	0.047766	0	0
COL11A1	1301	broad.mit.edu	37	1	103496799	103496799	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:103496799C>A	ENST00000358392.2	-	5	970	c.651_splice	c.e5-1	p.G218_splice	COL11A1_ENST00000512756.1_Splice_Site_p.G218_splice|COL11A1_ENST00000353414.4_Splice_Site_p.G218_splice|COL11A1_ENST00000370096.3_Splice_Site_p.G218_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	218	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGAATGTCCCCCTGGGAAAA	0.383000													14	22					0.00400662	0.00410361	0.028581	1	0
HECTD1	25831	broad.mit.edu	37	14	31642916	31642916	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:31642916C>T	ENST00000399332.1	-	5	1188	c.700G>A	c.(700-702)Gag>Aag	p.E234K	HECTD1_ENST00000553700.1_Missense_Mutation_p.E234K	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	234					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AACAGCTCCTCAGTTAATCCA	0.527000													13	11					0	0	0.091800	0	0
XIRP2	129446	broad.mit.edu	37	2	168067310	168067310	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:168067310G>T	ENST00000409195.1	+	4	717	c.628G>T	c.(628-630)Gtg>Ttg	p.V210L	XIRP2_ENST00000409273.1_5'UTR|XIRP2_ENST00000409728.1_Missense_Mutation_p.V243L|XIRP2_ENST00000295237.9_Missense_Mutation_p.V210L|XIRP2_ENST00000409756.2_Missense_Mutation_p.V210L|XIRP2_ENST00000409605.1_5'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.V210L|XIRP2_ENST00000420519.1_Missense_Mutation_p.V243L	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	35					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGGCGAGGGTGTGTCAGACCT	0.557000													73	146					5.96624e-29	8.61225e-29	0.048971	1	0
WDR96	80217	broad.mit.edu	37	10	105928572	105928572	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:105928572T>A	ENST00000357060.3	-	21	2736	c.2621A>T	c.(2620-2622)aAg>aTg	p.K874M	WDR96_ENST00000278064.2_Missense_Mutation_p.K805M|WDR96_ENST00000428666.1_Missense_Mutation_p.K875M	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	874										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CAAATAGCTCTTGGCTAAGTT	0.373000													216	225					0	0	0.048971	0	0
NTRK3	4916	broad.mit.edu	37	15	88576116	88576116	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:88576116C>T	ENST00000394480.1	-	14	1878	c.1557G>A	c.(1555-1557)caG>caA	p.Q519Q	NTRK3_ENST00000542733.2_Silent_p.Q421Q|NTRK3_ENST00000558676.1_Silent_p.Q511Q|NTRK3_ENST00000355254.2_Silent_p.Q519Q|NTRK3_ENST00000540489.2_Silent_p.Q519Q|NTRK3_ENST00000360948.2_Silent_p.Q519Q|NTRK3_ENST00000357724.2_Silent_p.Q511Q|NTRK3_ENST00000317501.3_Silent_p.Q519Q|NTRK3_ENST00000557856.1_Silent_p.Q511Q|NTRK3_ENST00000558306.1_5'UTR	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	519					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGTTGTGTCCCTGACGGAAGT	0.597000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			38	50					0	0	0.042209	0	0
ZBED4	9889	broad.mit.edu	37	22	50278348	50278348	+	Silent	SNP	G	G	T	rs143242906		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:50278348G>T	ENST00000216268.4	+	2	1515	c.1038G>T	c.(1036-1038)acG>acT	p.T346T		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	346						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		ACGGGGGCACGGGCATCCCGC	0.657000													28	3					8.58068e-18	1.1023e-17	0.034045	1	0
MAP3K8	1326	broad.mit.edu	37	10	30747105	30747105	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:30747105G>A	ENST00000263056.1	+	7	1662	c.966G>A	c.(964-966)acG>acA	p.T322T	MAP3K8_ENST00000542547.1_Silent_p.T322T|MAP3K8_ENST00000375321.1_Silent_p.T322T	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	322	Protein kinase.				cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding	p.T322T(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				ACATGCAGACGGGCACCCCAC	0.602000													50	51					0	0	0.048971	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920674	51920674	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:51920674G>A	ENST00000353836.5	-	2	304	c.83C>T	c.(82-84)tCa>tTa	p.S28L	SIGLEC10_ENST00000339313.5_Missense_Mutation_p.S28L|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.S28L|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.S28L|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.S28L|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.S28L|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.S28L|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.S28L|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.S28L	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	28	Ig-like V-type.			S -> P (in Ref. 4; AAK51124).	cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CACCATCACTGACTCCTGCAC	0.612000													131	104					0	0	0.048971	0	0
BAIAP3	8938	broad.mit.edu	37	16	1394319	1394319	+	Splice_Site	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:1394319G>A	ENST00000324385.5	+	17	1865		c.e17+1		BAIAP3_ENST00000421665.2_Splice_Site|BAIAP3_ENST00000426824.3_Splice_Site|BAIAP3_ENST00000562208.1_Splice_Site|BAIAP3_ENST00000568887.1_Splice_Site|BAIAP3_ENST00000397489.1_Splice_Site|BAIAP3_ENST00000397488.2_Splice_Site	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3						G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GGCCCTGAAGGTGTGTTCCAA	0.627000													19	7					0	0	0.038395	0	0
IL17RD	54756	broad.mit.edu	37	3	57148729	57148729	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:57148729C>A	ENST00000320057.5	-	0	411				IL17RD_ENST00000296318.7_Missense_Mutation_p.G101W|IL17RD_ENST00000463523.1_De_novo_Start_OutOfFrame|IL17RD_ENST00000427856.2_Missense_Mutation_p.G77W			Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D							Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		CCGAGGGCCCCTGGGGACCAA	0.547000													30	25					3.1745e-13	3.79706e-13	0.037714	1	0
OR5H6	79295	broad.mit.edu	37	3	97983469	97983469	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:97983469T>C	ENST00000383696.2	+	1	382	c.341T>C	c.(340-342)aTg>aCg	p.M114T	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TCTGAATGCATGGTACAATTT	0.393000													73	101					0	0	0.048971	0	0
LRRK1	79705	broad.mit.edu	37	15	101605612	101605612	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:101605612T>C	ENST00000284395.5	+	33	5361	c.4961T>C	c.(4960-4962)gTg>gCg	p.V1654A	RP11-505E24.2_ENST00000559857.1_RNA|LRRK1_ENST00000388948.3_Missense_Mutation_p.V1657A|LRRK1_ENST00000532145.1_3'UTR			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1657					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGTTTCCCGTGGTGCGGGGC	0.582000													54	112					0	0	0.048971	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966201	41966201	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:41966201C>T	ENST00000298919.7	+	10	1228	c.840C>T	c.(838-840)gaC>gaT	p.D280D	PDZRN4_ENST00000402685.2_Silent_p.D540D|PDZRN4_ENST00000539469.2_Silent_p.D282D			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	540	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GCACAACAGACACTGCAACAT	0.383000													107	56					0	0	0.048971	0	0
HIVEP2	3097	broad.mit.edu	37	6	143092972	143092972	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:143092972G>A	ENST00000367603.2	-	5	3646	c.2904C>T	c.(2902-2904)agC>agT	p.S968S	HIVEP2_ENST00000012134.2_Silent_p.S968S|HIVEP2_ENST00000367604.1_Silent_p.S968S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	968	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGCTTTCTTGGCTGGGGCTGC	0.517000													58	53					0	0	0.048971	0	0
RYR1	6261	broad.mit.edu	37	19	39037100	39037100	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:39037100G>T	ENST00000355481.4	+	87	12144	c.12013G>T	c.(12013-12015)Gag>Tag	p.E4005*	RYR1_ENST00000360985.3_Nonsense_Mutation_p.E4005*|RYR1_ENST00000359596.3_Nonsense_Mutation_p.E4010*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4010					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.E4010*(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGCCAGATCGAGCTGCTGAA	0.567000													29	44					1.22384e-17	1.56623e-17	0.054565	1	0
C1orf186	440712	broad.mit.edu	37	1	206239438	206239438	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:206239438A>G	ENST00000331555.5	-	6	1098	c.460T>C	c.(460-462)Tgg>Cgg	p.W154R		NM_001007544.1	NP_001007545.1	Q6ZWK4	CA186_HUMAN	chromosome 1 open reading frame 186	154						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	9			BRCA - Breast invasive adenocarcinoma(75;0.0754)			ACAAAATACCAGAAACTGGGC	0.423000													46	52					0	0	0.048971	0	0
MEGF10	84466	broad.mit.edu	37	5	126776464	126776464	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:126776464C>A	ENST00000274473.6	+	19	2534	c.2267C>A	c.(2266-2268)gCa>gAa	p.A756E	MEGF10_ENST00000503335.2_Missense_Mutation_p.A756E	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	756	EGF-like 14.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AAAGATTGTGCACTGATATGC	0.522000													106	125					1.22908e-42	1.94413e-42	0.048971	1	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273485	26273485	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:26273485G>T	ENST00000377733.2	+	1	342	c.282G>T	c.(280-282)gaG>gaT	p.E94D		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	94					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						CTTCCAGGGAGATCCAAACGG	0.582000													61	74					5.98616e-33	8.82926e-33	0.048971	1	0
CDH22	64405	broad.mit.edu	37	20	44879774	44879774	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:44879774C>G	ENST00000372262.3	-	1	560	c.160G>C	c.(160-162)Gcg>Ccg	p.A54P	CDH22_ENST00000537909.1_Missense_Mutation_p.A54P	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	54					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GCTCCCAGCGCGCCGTCCTGC	0.711000													11	10					0	0	0.054565	0	0
CHN2	1124	broad.mit.edu	37	7	29519962	29519962	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:29519962A>G	ENST00000222792.6	+	7	1174	c.644A>G	c.(643-645)cAc>cGc	p.H215R	CHN2_ENST00000546235.1_Missense_Mutation_p.H200R|CHN2_ENST00000539389.1_Missense_Mutation_p.H71R|CHN2_ENST00000539406.1_Missense_Mutation_p.H290R|CHN2_ENST00000439711.2_Missense_Mutation_p.H79R|CHN2_ENST00000421775.2_Missense_Mutation_p.H79R|CHN2_ENST00000495789.2_Missense_Mutation_p.H228R|CHN2_ENST00000435288.2_Intron|CHN2_ENST00000409041.4_Missense_Mutation_p.H79R|CHN2_ENST00000424025.2_Intron	NM_004067.2	NP_004058.1	P52757	CHIO_HUMAN	chimerin 2	215					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			breast(2)|endometrium(3)|large_intestine(2)|lung(12)|ovary(2)|urinary_tract(2)	23						GAGAAGACACACAACTTTAAG	0.473000													97	159					0	0	0.048971	0	0
TDRD6	221400	broad.mit.edu	37	6	46663671	46663671	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:46663671G>T	ENST00000544460.1	+	2	6414	c.6160G>T	c.(6160-6162)Gaa>Taa	p.E2054*	TDRD6_ENST00000316081.6_Nonsense_Mutation_p.E2054*	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	2054	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AACAGCTGAAGAAGGAACAAG	0.378000													61	344					2.3441e-25	3.25196e-25	0.048971	1	0
EPHA3	2042	broad.mit.edu	37	3	89499354	89499354	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:89499354C>A	ENST00000336596.2	+	15	2749	c.2524C>A	c.(2524-2526)Cga>Aga	p.R842R	EPHA3_ENST00000494014.1_Silent_p.R842R	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	842	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGAGGGCTATCGACTGCCACC	0.483000										TSP Lung(6;0.00050)			30	49					5.71845e-15	7.05171e-15	0.080422	1	0
MUC17	140453	broad.mit.edu	37	7	100676862	100676862	+	Nonsense_Mutation	SNP	C	C	A	rs71530303		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:100676862C>A	ENST00000306151.4	+	3	2229	c.2165C>A	c.(2164-2166)tCa>tAa	p.S722*		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	722	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGACCACTTCAACTGAAGCC	0.502000													32	444					1.99505e-19	2.5974e-19	0.050027	1	0
DNM1P46	196968	broad.mit.edu	37	15	100332044	100332044	+	RNA	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:100332044T>A	ENST00000341853.1	-	0	2147					NR_003260.1																						GCACTCCACCTCTCTGCCCCG	0.572000													11	26					0	0	0.080935	0	0
BAGE2	85319	broad.mit.edu	37	21	11058342	11058342	+	RNA	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:11058342A>G	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTAAAGGAGAGAAATCTCTT	0.358000													7	211					0	0	0.047766	0	0
SNHG14	104472715	broad.mit.edu	37	15	25349840	25349840	+	RNA	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:25349840T>C	ENST00000546682.1	+	0	2310				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000516123.1_RNA	NR_003361.1																						GCAAAACGAGTGAGCAAACCA	0.463000													89	99					0	0	0.048971	0	0
SORD	6652	broad.mit.edu	37	15	45361251	45361251	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:45361251G>T	ENST00000267814.9	+	7	966		c.e7+1		SORD_ENST00000558580.1_Splice_Site	NM_003104.5	NP_003095.2	Q00796	DHSO_HUMAN	sorbitol dehydrogenase						fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(4)	9		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	GGGCATCTACGTGAGTGGGCT	0.582000													13	42					7.93312e-07	8.55211e-07	0.020292	1	0
C14orf183	196913	broad.mit.edu	37	14	50551964	50551964	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:50551964C>G	ENST00000305273.1	-	4	499	c.500G>C	c.(499-501)tGg>tCg	p.W167S	RP11-58E21.5_ENST00000556019.2_lincRNA	NM_001014830.1	NP_001014830.1	Q8WXQ3	CN183_HUMAN	chromosome 14 open reading frame 183	167										endometrium(2)|large_intestine(2)|lung(3)	7						TCCTTGCTTCCACTCCTCCTC	0.393000													3	14					0	0	0.009096	0	0
DPYD	1806	broad.mit.edu	37	1	98157295	98157295	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:98157295A>C	ENST00000370192.3	-	7	840	c.740T>G	c.(739-741)cTa>cGa	p.L247R	DPYD_ENST00000423006.2_3'UTR|DPYD_ENST00000474241.1_5'UTR	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	247					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTCCTTCATTAGCTCAATCTC	0.368000													58	76					0	0	0.048971	0	0
GPR98	84059	broad.mit.edu	37	5	90021007	90021007	+	Silent	SNP	T	T	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:90021007T>G	ENST00000405460.2	+	47	10107	c.10011T>G	c.(10009-10011)ctT>ctG	p.L3337L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3337					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGCCTTCTCTTAACAGTGTGT	0.264000													6	21					0	0	0.029380	0	0
PKN3	29941	broad.mit.edu	37	9	131475465	131475465	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:131475465G>T	ENST00000291906.4	+	7	1363	c.970G>T	c.(970-972)Ggc>Tgc	p.G324C		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	324					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						GCGTGGCCGAGGCGAGCTTGC	0.706000													8	11					3.07112e-06	3.27425e-06	0.080935	1	0
NAV3	89795	broad.mit.edu	37	12	78592410	78592410	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:78592410C>G	ENST00000397909.2	+	36	6645	c.6472C>G	c.(6472-6474)Cag>Gag	p.Q2158E	NAV3_ENST00000266692.7_Missense_Mutation_p.Q1959E|NAV3_ENST00000536525.2_Missense_Mutation_p.Q2136E|NAV3_ENST00000228327.6_Missense_Mutation_p.Q2136E			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2158						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AACAATGAATCAGGGAGTTTC	0.284000										HNSCC(70;0.22)			39	109					0	0	0.111260	0	0
RNF17	56163	broad.mit.edu	37	13	25373689	25373689	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:25373689A>T	ENST00000255324.5	+	12	1608	c.1556A>T	c.(1555-1557)gAt>gTt	p.D519V	RNF17_ENST00000381921.1_Missense_Mutation_p.D519V|RNF17_ENST00000255325.5_Missense_Mutation_p.D520V	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	519					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTCATGGTAGATTTTGGAAAT	0.353000													52	14					0	0	0.048971	0	0
TGFB2	7042	broad.mit.edu	37	1	218607550	218607550	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:218607550C>A	ENST00000366929.4	+	4	1188	c.721C>A	c.(721-723)Cat>Aat	p.H241N	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Missense_Mutation_p.H213N	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	213					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		ATGGCTTCACCATAAAGGTTA	0.423000													37	64					4.90274e-10	5.61617e-10	0.086207	1	0
TF	7018	broad.mit.edu	37	3	133486935	133486935	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:133486935T>A	ENST00000402696.3	+	13	2034	c.1549T>A	c.(1549-1551)Tgt>Agt	p.C517S	TF_ENST00000264998.3_Missense_Mutation_p.C390S	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	517	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CTGTAAGCTGTGTATGGGCTC	0.468000													64	101					0	0	0.048971	0	0
DMBX1	127343	broad.mit.edu	37	1	46972733	46972733	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:46972733C>T	ENST00000371956.4	+	1	66	c.51C>T	c.(49-51)ctC>ctT	p.L17L	DMBX1_ENST00000360032.3_Silent_p.L17L	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	17	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					TGAACTCACTCAGCGCCATGT	0.637000													53	99					0	0	0.048971	0	0
ANK2	287	broad.mit.edu	37	4	114290764	114290764	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:114290764G>C	ENST00000357077.4	+	43	11466	c.11413G>C	c.(11413-11415)Gca>Cca	p.A3805P	ANK2_ENST00000264366.6_Missense_Mutation_p.A3772P|ANK2_ENST00000394537.3_Missense_Mutation_p.A1720P|ANK2_ENST00000506722.1_Missense_Mutation_p.A1711P|ANK2_ENST00000510275.2_Missense_Mutation_p.A372P|ANK2_ENST00000509550.1_Missense_Mutation_p.A896P	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3772					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TAGCACCCCTGCAGAGGAGGA	0.547000													54	56					0	0	0.048971	0	0
CUBN	8029	broad.mit.edu	37	10	17083166	17083166	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:17083166C>G	ENST00000377833.4	-	27	3948	c.3883G>C	c.(3883-3885)Ggg>Cgg	p.G1295R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1295	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCGGATACCCTATACTCTCT	0.378000													86	148					0	0	0.048971	0	0
ACSS3	79611	broad.mit.edu	37	12	81568589	81568589	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:81568589A>T	ENST00000548058.1	+	8	2031	c.1121A>T	c.(1120-1122)gAt>gTt	p.D374V	ACSS3_ENST00000548324.1_Missense_Mutation_p.D56V|ACSS3_ENST00000261206.3_Missense_Mutation_p.D373V			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	374						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GGAACACCAGATGCTGGCGCT	0.438000													29	81					0	0	0.045705	0	0
URB2	9816	broad.mit.edu	37	1	229781638	229781638	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:229781638G>A	ENST00000258243.2	+	6	3964	c.3828G>A	c.(3826-3828)ctG>ctA	p.L1276L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1276						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TGCTGAGGCTGCTACTGAACT	0.527000													7	239					0	0	0.058154	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146236139	146236139	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:146236139C>A	ENST00000508545.2	-	0	259				PPP2R2B_ENST00000530902.1_Intron|PPP2R2B_ENST00000453001.1_Intron|PPP2R2B_ENST00000394414.1_Intron|PPP2R2B_ENST00000394413.3_Intron|PPP2R2B_ENST00000394410.2_De_novo_Start_InFrame|PPP2R2B_ENST00000394411.4_Intron|PPP2R2B_ENST00000394409.3_Intron|PPP2R2B_ENST00000504198.1_Intron|PPP2R2B_ENST00000336640.6_Intron|PPP2R2B_ENST00000356826.3_Intron			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta						apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGGTTCTCCCTTGGCTCCTG	0.398000													40	40					1.15183e-24	1.58494e-24	0.111260	1	0
SLC12A1	6557	broad.mit.edu	37	15	48500073	48500073	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:48500073G>T	ENST00000396577.3	+	2	372	c.157G>T	c.(157-159)Gaa>Taa	p.E53*	SLC12A1_ENST00000330289.6_Nonsense_Mutation_p.E53*|SLC12A1_ENST00000561031.1_Nonsense_Mutation_p.E53*|SLC12A1_ENST00000380993.3_Nonsense_Mutation_p.E53*|SLC12A1_ENST00000558405.1_Nonsense_Mutation_p.E53*	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	53					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTTTGGGGATGAAGCTCAGAA	0.433000													26	51					1.16021e-09	1.31129e-09	0.034045	1	0
CHML	1122	broad.mit.edu	37	1	241798846	241798846	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:241798846C>A	ENST00000366553.1	-	1	386	c.223G>T	c.(223-225)Gta>Tta	p.V75L	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000469376.1_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	75					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCCTGCCATACAACAGTACTT	0.438000													88	231					6.64136e-43	1.05298e-42	0.048971	1	0
COMMD1	150684	broad.mit.edu	37	2	62228015	62228015	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:62228015G>T	ENST00000311832.5	+	2	392	c.360G>T	c.(358-360)cgG>cgT	p.R120R	COMMD1_ENST00000472729.1_3'UTR|COMMD1_ENST00000538736.1_Silent_p.R120R	NM_152516.2	NP_689729.1	Q8N668	COMD1_HUMAN	copper metabolism (Murr1) domain containing 1	120	COMM.				copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			large_intestine(1)|liver(2)|lung(5)|ovary(1)	9	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			GCGGGCTTCGGGGCCTGAGCT	0.498000													34	41					2.19962e-31	3.19559e-31	0.104719	1	0
SCNN1G	6340	broad.mit.edu	37	16	23197657	23197657	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:23197657C>T	ENST00000300061.2	+	2	208	c.65C>T	c.(64-66)gCg>gTg	p.A22V		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	22					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GGCCCTCAGGCGCCGACCATT	0.612000													21	40					0	0	0.083992	0	0
METTL1	4234	broad.mit.edu	37	12	58162892	58162892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:58162892C>A	ENST00000324871.7	-	6	1427	c.718G>T	c.(718-720)Gag>Tag	p.E240*	METTL1_ENST00000257848.7_3'UTR	NM_005371.5	NP_005362.3	Q9UBP6	TRMB_HUMAN	methyltransferase like 1	240	S-adenosyl-L-methionine binding.					cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding	p.E240K(1)		large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TTCTTCCCCTCCTCAGTTGAG	0.542000													69	129					2.10328e-26	2.94199e-26	0.048971	1	0
SLC9C2	284525	broad.mit.edu	37	1	173569258	173569258	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:173569258C>T	ENST00000367714.3	-	3	648	c.226G>A	c.(226-228)Gag>Aag	p.E76K	SLC9C2_ENST00000536496.1_Intron|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	76					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TACAGTACCTCAACAGAATTG	0.348000													25	35					0	0	0.030593	0	0
MEDAG	84935	broad.mit.edu	37	13	31480658	31480658	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:31480658G>T	ENST00000380482.4	+	1	331	c.6G>T	c.(4-6)gcG>gcT	p.A2A	TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000585870.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000588726.1_RNA	NM_032849.3	NP_116238.2			mesenteric estrogen-dependent adipogenesis																		CGGGCATGGCGGGGGCGGCCT	0.741000													8	1					6.44725e-10	7.36052e-10	0.069288	1	0
PDCD1	5133	broad.mit.edu	37	2	242794882	242794882	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:242794882G>T	ENST00000334409.5	-	2	396	c.327C>A	c.(325-327)agC>agA	p.S109R		NM_005018.2	NP_005009.2	Q15116	PDCD1_HUMAN	programmed cell death 1	109	Ig-like V-type.				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		CCCTGACCACGCTCATGTGGA	0.677000													7	24					1.58986e-06	1.70847e-06	0.069234	1	0
NFATC4	4776	broad.mit.edu	37	14	24842998	24842998	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:24842998G>T	ENST00000413692.2	+	6	1990	c.1846G>T	c.(1846-1848)Gtg>Ttg	p.V616L	NFATC4_ENST00000539237.2_Missense_Mutation_p.V585L|NFATC4_ENST00000422617.3_Missense_Mutation_p.V541L|NFATC4_ENST00000554473.1_Missense_Mutation_p.V88L|NFATC4_ENST00000557451.1_Missense_Mutation_p.V483L|NFATC4_ENST00000553469.1_Missense_Mutation_p.V585L|NFATC4_ENST00000554661.1_Missense_Mutation_p.V483L|NFATC4_ENST00000554966.1_Missense_Mutation_p.V566L|NFATC4_ENST00000554344.1_Missense_Mutation_p.V483L|NFATC4_ENST00000555167.1_Missense_Mutation_p.V88L|NFATC4_ENST00000553879.1_Missense_Mutation_p.V483L|NFATC4_ENST00000556759.1_Missense_Mutation_p.V88L|NFATC4_ENST00000554591.1_Missense_Mutation_p.V616L|NFATC4_ENST00000556169.1_Missense_Mutation_p.V541L|NFATC4_ENST00000554050.1_Missense_Mutation_p.V553L|NFATC4_ENST00000555453.1_Missense_Mutation_p.V541L|NFATC4_ENST00000250373.4_Missense_Mutation_p.V553L|NFATC4_ENST00000555590.1_Missense_Mutation_p.V566L|NFATC4_ENST00000556279.1_Missense_Mutation_p.V585L|NFATC4_ENST00000424781.2_Missense_Mutation_p.V566L|NFATC4_ENST00000553708.1_Missense_Mutation_p.V553L	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	553	IPT/TIG.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		TGTACGGCTGGTGTTCCGGGT	0.602000													46	43					9.40368e-32	1.37205e-31	0.048971	1	0
DENND5A	23258	broad.mit.edu	37	11	9215202	9215202	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:9215202C>G	ENST00000328194.3	-	5	1296	c.976G>C	c.(976-978)Gag>Cag	p.E326Q	DENND5A_ENST00000530044.1_Missense_Mutation_p.E326Q	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	326	DENN.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTAATCGTCTCCGCCACAGTC	0.443000													53	10					0	0	0.048971	0	0
SETBP1	26040	broad.mit.edu	37	18	42529998	42529998	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr18:42529998C>A	ENST00000282030.5	+	4	989	c.693C>A	c.(691-693)gtC>gtA	p.V231V		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	231			V -> L (in dbSNP:rs11082414).			nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCGGACCCGTCACTCAGAATT	0.547000									Schinzel-Giedion syndrome				112	118					9.50027e-55	1.60391e-54	0.048971	1	0
SF3B4	10262	broad.mit.edu	37	1	149897745	149897745	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:149897745C>T	ENST00000271628.8	-	4	1480	c.896G>A	c.(895-897)gGt>gAt	p.G299D		NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa	299						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGGCATCCCACCCGGTGGGAA	0.602000													27	61					0	0	0.034045	0	0
NLRP5	126206	broad.mit.edu	37	19	56569690	56569690	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:56569690C>T	ENST00000390649.3	+	14	3384	c.3384C>T	c.(3382-3384)aaC>aaT	p.N1128N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1128						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCAGTCTAAACCTGGTGCAGA	0.512000													42	46					0	0	0.111260	0	0
CRELD1	78987	broad.mit.edu	37	3	9979755	9979755	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:9979755G>A	ENST00000383811.3	+	4	1024	c.425G>A	c.(424-426)tGc>tAc	p.C142Y	CRELD1_ENST00000452070.1_Missense_Mutation_p.C142Y|CRELD1_ENST00000397170.3_Missense_Mutation_p.C142Y|CRELD1_ENST00000326434.5_Missense_Mutation_p.C142Y	NM_015513.4	NP_056328.2	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1	142					cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|urinary_tract(1)	14						CTGAAGCTCTGCTGCCCCGCA	0.647000													13	23					0	0	0.020292	0	0
FZD2	2535	broad.mit.edu	37	17	42635672	42635672	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:42635672A>T	ENST00000315323.3	+	1	748	c.616A>T	c.(616-618)Aag>Tag	p.K206*		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	206					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCGCGTCCTCAAGGTGCCATC	0.701000													21	19					0	0	0.062417	0	0
PDE3B	5140	broad.mit.edu	37	11	14665857	14665857	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:14665857G>C	ENST00000282096.4	+	1	589	c.236G>C	c.(235-237)cGc>cCc	p.R79P	PDE3B_ENST00000534317.1_3'UTR|PDE3B_ENST00000455098.2_Missense_Mutation_p.R79P	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	79					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TGCCGGGCGCGCCTCTCGCTG	0.751000													8	2					0	0	0.080935	0	0
MRPL3	11222	broad.mit.edu	37	3	131208916	131208916	+	Silent	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:131208916T>A	ENST00000264995.3	-	5	624	c.477A>T	c.(475-477)acA>acT	p.T159T	MRPL3_ENST00000425847.2_Silent_p.T186T|MRPL3_ENST00000506946.1_5'UTR	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	159					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						CCAATATGGATGTAGCTTTCT	0.338000													58	59					0	0	0.048971	0	0
LAMA2	3908	broad.mit.edu	37	6	129774214	129774214	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:129774214G>T	ENST00000421865.2	+	46	6560	c.6511G>T	c.(6511-6513)Gtt>Ttt	p.V2171F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2171	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAATAATATTGTTGTCAACGT	0.338000													38	57					6.70999e-13	7.95562e-13	0.069456	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100629	89100629	+	RNA	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:89100629C>A	ENST00000393525.3	+	0	1103																											CTGGATGATGCTCGCAACAAA	0.393000													8	159					2.23348e-06	2.38497e-06	0.028581	1	0
KLC2	64837	broad.mit.edu	37	11	66031147	66031147	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:66031147A>T	ENST00000394065.2	+	4	1370	c.352A>T	c.(352-354)Aag>Tag	p.K118*	KLC2_ENST00000394067.2_Nonsense_Mutation_p.K257*|KLC2_ENST00000421552.1_Nonsense_Mutation_p.K180*|KLC2_ENST00000394066.2_Nonsense_Mutation_p.K180*|KLC2_ENST00000417856.1_Nonsense_Mutation_p.K257*|KLC2_ENST00000316924.5_Nonsense_Mutation_p.K257*|KLC2_ENST00000394078.1_Intron			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	257					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						GAACAAGTACAAGGAGGCTGC	0.612000													92	112					0	0	0.048971	0	0
TM9SF1	10548	broad.mit.edu	37	14	24659658	24659658	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:24659658C>A	ENST00000530611.1	-	9	2015	c.1982G>T	c.(1981-1983)cGg>cTg	p.R661L	TM9SF1_ENST00000524835.1_Missense_Mutation_p.R365L|TM9SF1_ENST00000528669.1_Missense_Mutation_p.R452L|TM9SF1_ENST00000396854.4_Missense_Mutation_p.R452L|TM9SF1_ENST00000261789.4_Missense_Mutation_p.R452L|TM9SF1_ENST00000556387.1_Missense_Mutation_p.R661L			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	452					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		TGGAATCTCCCGGGCGATGTT	0.542000													112	110					4.21061e-56	7.16226e-56	0.048971	1	0
PPM1D	8493	broad.mit.edu	37	17	58678173	58678173	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:58678173C>T	ENST00000305921.3	+	1	630	c.398C>T	c.(397-399)tCc>tTc	p.S133F		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	133	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TTCACCTCGTCCGAGCCGGCT	0.597000													35	78					0	0	0.064281	0	0
VPS37D	155382	broad.mit.edu	37	7	73085416	73085416	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:73085416G>T	ENST00000324941.4	+	4	600	c.466G>T	c.(466-468)Gcc>Tcc	p.A156S	VPS37D_ENST00000451519.1_Missense_Mutation_p.A71S	NM_001077621.1	NP_001071089.1	Q86XT2	VP37D_HUMAN	vacuolar protein sorting 37 homolog D (S. cerevisiae)	156	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	late endosome membrane				central_nervous_system(1)|ovary(1)	2		Lung NSC(55;0.0908)|all_lung(88;0.198)				GCGTGGCCGCGCCCTGGCCCA	0.711000													21	44					7.26314e-15	8.92404e-15	0.034045	1	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324424	39324424	+	Splice_Site	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:39324424T>C	ENST00000391356.2	-	1	0	c.0_splice	c.e1-1	p.M1_splice		NM_033187.1	NP_149443.1	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	1						keratin filament				breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GAGCTGACCATGGCGTCAGAG	0.587000													44	53					0	0	0.048971	0	0
AIM1L	55057	broad.mit.edu	37	1	26669332	26669332	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:26669332C>T	ENST00000527815.1	-	4	544	c.495G>A	c.(493-495)ctG>ctA	p.L165L	AIM1L_ENST00000308182.5_5'UTR	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	84	Beta/gamma crystallin 'Greek key' 3.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CAGGCAGGACCAGCTTCTGAC	0.592000													46	68					0	0	0.048971	0	0
UNC93A	54346	broad.mit.edu	37	6	167728843	167728843	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:167728843G>T	ENST00000230256.3	+	8	1452	c.1277G>T	c.(1276-1278)gGg>gTg	p.G426V	UNC93A_ENST00000366829.2_Missense_Mutation_p.G384V	NM_018974.3	NP_061847.2	Q86WB7	UN93A_HUMAN	unc-93 homolog A (C. elegans)	426						integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTGGCGTATGGGCTTGTGGAG	0.542000													147	284					7.97313e-81	1.41675e-80	0.048971	1	0
LRP2BP	55805	broad.mit.edu	37	4	186294187	186294187	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:186294187G>A	ENST00000362004.3	-	6	1443	c.632C>T	c.(631-633)tCc>tTc	p.S211F	LRP2BP_ENST00000510776.1_Missense_Mutation_p.S183F|RP11-714G18.1_ENST00000514884.1_RNA|LRP2BP_ENST00000328559.7_Missense_Mutation_p.S209F|LRP2BP_ENST00000505916.1_Missense_Mutation_p.S209F			Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	209						cytoplasm	protein binding			breast(1)|endometrium(2)|large_intestine(6)|lung(3)|prostate(1)|skin(2)	15		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		TGCACCCTGGGACTCCAGATT	0.473000													57	105					0	0	0.048971	0	0
EIF2D	1939	broad.mit.edu	37	1	206767041	206767041	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:206767041G>T	ENST00000271764.2	-	14	1819	c.1611C>A	c.(1609-1611)gcC>gcA	p.A537A	EIF2D_ENST00000472709.2_Intron|EIF2D_ENST00000367114.3_Silent_p.A413A	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	537	SUI1.				intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TGGCCCCAGGGGCAGGATTGA	0.607000													83	87					2.05912e-35	3.11167e-35	0.048971	1	0
NDE1	54820	broad.mit.edu	37	16	15785139	15785139	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:15785139G>T	ENST00000396355.1	+	7	1488	c.662G>T	c.(661-663)gGa>gTa	p.G221V	NDE1_ENST00000396353.2_Missense_Mutation_p.G221V|NDE1_ENST00000396354.1_Missense_Mutation_p.G221V|NDE1_ENST00000342673.5_Missense_Mutation_p.G221V	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	221	Interaction with CENPF (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						GCTCACCGAGGACCCAGCTCA	0.562000													29	2					9.80776e-20	1.28182e-19	0.030593	1	0
FZD2	2535	broad.mit.edu	37	17	42636025	42636025	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:42636025G>A	ENST00000315323.3	+	1	1101	c.969G>A	c.(967-969)aaG>aaA	p.K323K		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	323					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		AGGGCACCAAGAAGGAGGGCT	0.622000													29	61					0	0	0.037714	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889965	23889965	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:23889965G>T	ENST00000532292.1	-	1	1210	c.1116C>A	c.(1114-1116)acC>acA	p.T372T		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGGCCCTGGAGGTGCTCGGGC	0.657000													17	10					1.15088e-07	1.25264e-07	0.028581	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872703	51872703	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:51872703C>A	ENST00000371497.5	+	2	3593	c.2706C>A	c.(2704-2706)aaC>aaA	p.N902K	TSHZ2_ENST00000603338.2_Missense_Mutation_p.N899K|RP4-678D15.1_ENST00000606932.1_RNA|TSHZ2_ENST00000329613.6_Missense_Mutation_p.N899K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	902					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			GGCTGGCCAACGTCAAGTACC	0.488000													78	45					8.6838e-40	1.35459e-39	0.048971	1	0
C2orf71	388939	broad.mit.edu	37	2	29294983	29294983	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:29294983G>T	ENST00000331664.5	-	1	2144	c.2145C>A	c.(2143-2145)gcC>gcA	p.A715A		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	715					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CTGTGGCCTTGGCAGCCTCAC	0.532000													79	53					1.61229e-46	2.59886e-46	0.048971	1	0
HIST3H2BB	128312	broad.mit.edu	37	1	228646196	228646196	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:228646196C>T	ENST00000369160.2	+	1	389	c.366C>T	c.(364-366)taC>taT	p.Y122Y		NM_175055.2	NP_778225.1	Q8N257	H2B3B_HUMAN	histone cluster 3, H2bb	122					nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		Prostate(94;0.183)				TCACCAAGTACACCAGCTCCA	0.617000													13	25					0	0	0.028581	0	0
TLN2	83660	broad.mit.edu	37	15	62948150	62948150	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:62948150G>T	ENST00000561311.1	+	7	755	c.525G>T	c.(523-525)tgG>tgT	p.W175C	TLN2_ENST00000306829.6_Missense_Mutation_p.W175C			Q9Y4G6	TLN2_HUMAN	talin 2	175	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CAGTAAATTGGCTGGATCACA	0.378000													26	50					2.27525e-19	2.95652e-19	0.091800	1	0
ITPR3	3710	broad.mit.edu	37	6	33652605	33652605	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:33652605A>C	ENST00000374316.5	+	40	6252	c.5192A>C	c.(5191-5193)gAg>gCg	p.E1731A	ITPR3_ENST00000605930.1_Missense_Mutation_p.E1731A			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1731					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CTGGACAAGGAGGGGGCCACC	0.627000													36	57					0	0	0.039052	0	0
SARDH	1757	broad.mit.edu	37	9	136573446	136573446	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:136573446A>G	ENST00000371872.4	-	11	1690	c.1433T>C	c.(1432-1434)cTg>cCg	p.L478P	SARDH_ENST00000439388.1_Missense_Mutation_p.L478P|SARDH_ENST00000422262.2_Missense_Mutation_p.L310P	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	478					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCGCCCGGCCAGCGGCTCATC	0.652000													10	36					0	0	0.055883	0	0
XIRP2	129446	broad.mit.edu	37	2	168101776	168101776	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:168101776G>T	ENST00000409195.1	+	9	3963	c.3874G>T	c.(3874-3876)Gac>Tac	p.D1292Y	XIRP2_ENST00000409273.1_Missense_Mutation_p.D1070Y|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1292Y|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1117					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAAGAATCTGACTATATCAG	0.368000													112	199					2.01602e-52	3.34521e-52	0.048971	1	0
GON4L	54856	broad.mit.edu	37	1	155735059	155735059	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:155735059G>C	ENST00000437809.1	-	21	4327	c.4205C>G	c.(4204-4206)tCa>tGa	p.S1402*	GON4L_ENST00000271883.5_Nonsense_Mutation_p.S1402*|GON4L_ENST00000368331.1_Nonsense_Mutation_p.S1402*|GON4L_ENST00000361040.5_Nonsense_Mutation_p.S1402*|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1402					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATCTGTCCCTGAGGTTCCTTC	0.483000													4	112					0	0	0.009096	0	0
SETX	23064	broad.mit.edu	37	9	135172287	135172287	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:135172287C>A	ENST00000372169.2	-	14	6118	c.5936G>T	c.(5935-5937)cGt>cTt	p.R1979L	SETX_ENST00000224140.5_Missense_Mutation_p.R1979L|SETX_ENST00000393220.1_Missense_Mutation_p.R1979L			Q7Z333	SETX_HUMAN	senataxin	1979					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGTCAGTAGACGATAGAGGAG	0.398000													22	52					1.55469e-16	1.96001e-16	0.083992	1	0
TMEM132D	121256	broad.mit.edu	37	12	129566381	129566381	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:129566381C>A	ENST00000422113.2	-	7	2172	c.1846G>T	c.(1846-1848)Gtg>Ttg	p.V616L	TMEM132D_ENST00000389441.4_Missense_Mutation_p.V154L	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	616						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGCTCCTCCACCTGCATGAAG	0.567000													11	114					9.70103e-10	1.1001e-09	0.069234	1	0
MYO16	23026	broad.mit.edu	37	13	109817397	109817397	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr13:109817397C>A	ENST00000356711.2	+	33	5373	c.5247C>A	c.(5245-5247)tcC>tcA	p.S1749S	MYO16-AS1_ENST00000439299.1_RNA|MYO16_ENST00000357550.2_Silent_p.S1749S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1749					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATGGAAATTCCATCTCAAATG	0.323000													16	39					1.15088e-07	1.25264e-07	0.028581	1	0
C19orf80	55908	broad.mit.edu	37	19	11350393	11350393	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:11350393C>A	ENST00000252453.8	+	1	99	c.80C>A	c.(79-81)cCa>cAa	p.P27Q	C19orf80_ENST00000591200.1_Intron|DOCK6_ENST00000294618.7_Intron	NM_018687.6	NP_061157.3	Q6UXH0	TD26_HUMAN	chromosome 19 open reading frame 80	27						extracellular region				NS(1)|breast(1)|endometrium(2)	4						ATGGGCGGCCCAGAACTGGCA	0.657000													65	45					2.42712e-22	3.27977e-22	0.048971	1	0
TRPA1	8989	broad.mit.edu	37	8	72945894	72945894	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:72945894G>T	ENST00000262209.4	-	23	3060	c.2853C>A	c.(2851-2853)gtC>gtA	p.V951V	RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron|RP11-383H13.1_ENST00000524152.1_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	951						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AATTCATGAGGACAATTGGGA	0.308000													44	82					2.37825e-27	3.35432e-27	0.039052	1	0
ZNF141	7700	broad.mit.edu	37	4	337570	337570	+	Splice_Site	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:337570G>A	ENST00000240499.7	+	2	152		c.e2-1		ZNF141_ENST00000505939.1_Splice_Site|ZNF141_ENST00000512994.1_Splice_Site	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141						anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						TGTATTTTCAGGAACTCTTAA	0.423000													23	44					0	0	0.069288	0	0
FAM181B	220382	broad.mit.edu	37	11	82443607	82443607	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:82443607G>A	ENST00000329203.3	-	1	1299	c.1165C>T	c.(1165-1167)Cat>Tat	p.H389Y		NM_175885.3	NP_787081.2	A6NEQ2	F181B_HUMAN	family with sequence similarity 181, member B	389										large_intestine(1)|lung(2)|prostate(1)	4						GACACCTGATGGGGCGGCGGC	0.706000													11	24					0	0	0.080935	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174341	150174341	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:150174341G>A	ENST00000307271.3	+	5	2045	c.1471G>A	c.(1471-1473)Gtt>Att	p.V491I		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	491	Poly-Val.					endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GGAGGTGGTGGTTGTGGACAC	0.582000													75	107					0	0	0.048971	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220332740	220332740	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:220332740C>A	ENST00000358951.2	-	29	3365	c.3249G>T	c.(3247-3249)agG>agT	p.R1083S		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	1083					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TTCGGCATAACCTATCTTTTG	0.279000													11	21					7.03913e-09	7.85089e-09	0.093190	1	0
SECISBP2	79048	broad.mit.edu	37	9	91965627	91965627	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:91965627G>A	ENST00000375807.3	+	14	2044	c.1973G>A	c.(1972-1974)cGt>cAt	p.R658H	SECISBP2_ENST00000534113.2_Missense_Mutation_p.R590H|SECISBP2_ENST00000339901.4_Missense_Mutation_p.R585H	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	658					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						TTCCAAGACCGTATGTACCAG	0.443000													5	328					0	0	0.014758	0	0
COL6A6	131873	broad.mit.edu	37	3	130289995	130289995	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:130289995C>A	ENST00000358511.6	+	6	2766	c.2735C>A	c.(2734-2736)cCc>cAc	p.P912H	COL6A6_ENST00000453409.2_Missense_Mutation_p.P912H	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	912	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AAGGGGGTCCCCCAAGTCCTC	0.562000													39	51					4.32679e-17	5.49576e-17	0.092188	1	0
PDE1A	5136	broad.mit.edu	37	2	183104919	183104919	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:183104919C>A	ENST00000435564.1	-	3	516	c.316G>T	c.(316-318)Ggg>Tgg	p.G106W	PDE1A_ENST00000351439.5_Missense_Mutation_p.G90W|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000331935.6_Missense_Mutation_p.G106W|PDE1A_ENST00000456212.1_Missense_Mutation_p.G106W|PDE1A_ENST00000358139.2_Missense_Mutation_p.G106W|PDE1A_ENST00000409365.1_Missense_Mutation_p.G90W|PDE1A_ENST00000536095.1_Missense_Mutation_p.G2W|PDE1A_ENST00000346717.4_Missense_Mutation_p.G72W|PDE1A_ENST00000410103.1_Missense_Mutation_p.G106W	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	106					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTTGTCATCCCCATTTTCCGT	0.428000													110	239					3.676e-42	5.80105e-42	0.048971	1	0
TNS3	64759	broad.mit.edu	37	7	47440037	47440037	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:47440037T>A	ENST00000398879.1	-	15	1238	c.872A>T	c.(871-873)tAt>tTt	p.Y291F	TNS3_ENST00000355730.3_Intron|TNS3_ENST00000311160.9_Missense_Mutation_p.Y291F			Q68CZ2	TENS3_HUMAN	tensin 3	291	C2 tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						AACCTTCCCATAGTCAGGAAA	0.428000													71	90					0	0	0.048971	0	0
PTPRC	5788	broad.mit.edu	37	1	198677262	198677262	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:198677262G>T	ENST00000367376.2	+	10	1070	c.898_splice	c.e10-1	p.G300_splice	PTPRC_ENST00000442510.2_Splice_Site_p.G302_splice|PTPRC_ENST00000594404.1_Splice_Site_p.G139_splice|PTPRC_ENST00000348564.6_Splice_Site_p.G141_splice|PTPRC_ENST00000352140.3_Splice_Site_p.G252_splice	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	300					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TTCTTGTCAGGGGTTGAAAAG	0.303000													37	71					4.14481e-20	5.43805e-20	0.086207	1	0
PRPF39	55015	broad.mit.edu	37	14	45565408	45565408	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:45565408G>C	ENST00000355765.6	+	3	597	c.427G>C	c.(427-429)Gac>Cac	p.D143H		NM_017922.3	NP_060392.3	Q86UA1	PRP39_HUMAN	pre-mRNA processing factor 39	143					mRNA processing|RNA splicing	nucleus	binding			breast(2)|endometrium(2)|kidney(4)|lung(3)|ovary(1)	12						AAAGCGGCACGACAACATTAA	0.368000													11	14					0	0	0.093190	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130897670	130897670	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:130897670C>A	ENST00000509018.1	-	5	557		c.e5+1		RAPGEF6_ENST00000308008.6_Splice_Site|RAPGEF6_ENST00000507093.1_Splice_Site|RAPGEF6_ENST00000503398.2_Intron|RAPGEF6_ENST00000307984.5_Splice_Site|FNIP1_ENST00000514667.1_Splice_Site|RAPGEF6_ENST00000510071.1_Splice_Site|RAPGEF6_ENST00000296859.6_Splice_Site	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AAAGTTCTTACCACAATCATT	0.308000													53	107					5.2118e-15	6.43866e-15	0.048971	1	0
CELA3B	23436	broad.mit.edu	37	1	22310714	22310714	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:22310714G>T	ENST00000337107.6	+	6	551	c.532G>T	c.(532-534)Gcc>Tcc	p.A178S		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	178	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						GCTGCAGGAGGCCCTGCTGCC	0.632000													22	41					2.08457e-15	2.59421e-15	0.045705	1	0
TTC21A	199223	broad.mit.edu	37	3	39162658	39162658	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:39162658G>A	ENST00000301819.6	+	9	1272	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	TTC21A_ENST00000440121.1_Silent_p.K316K|TTC21A_ENST00000431162.2_Silent_p.K365K	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	365							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AACTGGACAAGGATGGCATGG	0.542000													31	42					0	0	0.086207	0	0
PSD3	23362	broad.mit.edu	37	8	18432723	18432723	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:18432723C>A	ENST00000440756.2	-	13	2662	c.2560G>T	c.(2560-2562)Gca>Tca	p.A854S	PSD3_ENST00000286485.8_Missense_Mutation_p.A318S|PSD3_ENST00000428502.2_Missense_Mutation_p.A181S|PSD3_ENST00000327040.8_Missense_Mutation_p.A852S|PSD3_ENST00000523619.1_Missense_Mutation_p.A787S			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	853	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GCCTTGGATGCCAATGCGTGG	0.428000													154	182					1.29554e-71	2.27814e-71	0.048971	1	0
ZSWIM4	65249	broad.mit.edu	37	19	13941161	13941161	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:13941161G>A	ENST00000254323.2	+	13	2456	c.2267G>A	c.(2266-2268)cGc>cAc	p.R756H	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.R590H	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	756							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GCCTGCGCCCGCACCCTGGCC	0.672000													7	531					0	0	0.029380	0	0
RYR3	6263	broad.mit.edu	37	15	34042406	34042406	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:34042406C>T	ENST00000389232.4	+	57	8388	c.8318C>T	c.(8317-8319)aCt>aTt	p.T2773I	RYR3_ENST00000415757.3_Missense_Mutation_p.T2773I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2773	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACACCTTGACTGCCAAGGAA	0.507000													5	18					0	0	0.029380	0	0
SIX4	51804	broad.mit.edu	37	14	61190693	61190693	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:61190693C>G	ENST00000216513.4	-	1	159	c.100G>C	c.(100-102)Gaa>Caa	p.E34Q		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	34						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		CCCGCCACTTCTCGGTGCGCC	0.706000													44	106					0	0	0.048971	0	0
CEP89	84902	broad.mit.edu	37	19	33444564	33444564	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:33444564C>A	ENST00000305768.4	-	4	537	c.449G>T	c.(448-450)gGa>gTa	p.G150V	CEP89_ENST00000590597.1_Missense_Mutation_p.G150V	NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	150						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						ACTGTGGCCTCCTCTGTCCTC	0.493000													12	624					4.74835e-14	5.761e-14	0.045705	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118386475	118386475	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:118386475G>T	ENST00000537242.1	+	0	457				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		CGGGTTGTTGGGGCGGAGACA	0.562000													8	13					2.17888e-05	2.29409e-05	0.058154	1	0
SCARA5	286133	broad.mit.edu	37	8	27823991	27823991	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:27823991C>A	ENST00000354914.3	-	3	666	c.181G>T	c.(181-183)Gct>Tct	p.A61S	SCARA5_ENST00000301906.4_Intron|SCARA5_ENST00000518030.1_Intron|SCARA5_ENST00000524352.1_Missense_Mutation_p.A61S|SCARA5_ENST00000380385.2_Missense_Mutation_p.A61S	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	61					cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CCCAGGACAGCATGCTTCAGG	0.542000													122	176					5.80419e-74	1.02596e-73	0.048971	1	0
GYLTL1B	120071	broad.mit.edu	37	11	45946098	45946098	+	Silent	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:45946098C>G	ENST00000531526.1	+	5	645	c.534C>G	c.(532-534)ctC>ctG	p.L178L	GYLTL1B_ENST00000536139.1_Silent_p.L147L|GYLTL1B_ENST00000401752.1_Silent_p.L178L|GYLTL1B_ENST00000325468.5_Silent_p.L178L|GYLTL1B_ENST00000529052.1_Silent_p.L147L|GYLTL1B_ENST00000389968.3_5'UTR	NM_152312.3	NP_689525.3	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	178					muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(35;0.226)		ACTCCGGCCTCTATGGGCTAA	0.602000													8	37					0	0	0.069234	0	0
COPS2	9318	broad.mit.edu	37	15	49426538	49426538	+	Splice_Site	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:49426538T>C	ENST00000388901.5	-	7	787	c.715_splice	c.e7+1	p.R238_splice	COPS2_ENST00000299259.6_Splice_Site_p.R245_splice|COPS2_ENST00000542928.1_Splice_Site_p.R174_splice	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	238					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		CAAACTTGCCTCTGATAACTC	0.418000													20	29					0	0	0.069288	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839660	27839660	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:27839660C>T	ENST00000356790.2	+	3	482	c.237C>T	c.(235-237)caC>caT	p.H79H		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	79										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CTGCTTCACACACAAGACATC	0.498000													14	0					0	0	0.024245	0	0
FAM83C	128876	broad.mit.edu	37	20	33874960	33874960	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:33874960G>A	ENST00000374408.3	-	4	1718	c.1622C>T	c.(1621-1623)cCa>cTa	p.P541L		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	541										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTGTCCTCTGGGGCCTGCTC	0.662000													31	47					0	0	0.054565	0	0
LRIT1	26103	broad.mit.edu	37	10	85992365	85992365	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:85992365G>T	ENST00000372105.3	-	4	1211	c.1190C>A	c.(1189-1191)tCt>tAt	p.S397Y		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	397						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GCTGGGCACAGAGGGTCCAGT	0.617000													26	30					7.26314e-15	8.92404e-15	0.034045	1	0
FLI1	2313	broad.mit.edu	37	11	128680420	128680420	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:128680420G>T	ENST00000344954.6	+	9	1185	c.797G>T	c.(796-798)tGt>tTt	p.C266F	FLI1_ENST00000534087.1_Missense_Mutation_p.C266F|FLI1_ENST00000281428.8_Missense_Mutation_p.C233F|FLI1_ENST00000429175.2_Missense_Mutation_p.C299F|FLI1_ENST00000525560.1_Missense_Mutation_p.C106F			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	299					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AACGCCAGCTGTATCACCTGG	0.607000			T	EWSR1	Ewing sarcoma								12	22					1.5739e-10	1.81212e-10	0.028581	1	0
FNDC7	163479	broad.mit.edu	37	1	109268418	109268418	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:109268418C>T	ENST00000370017.3	+	6	1180	c.903C>T	c.(901-903)ggC>ggT	p.G301G	FNDC7_ENST00000271311.2_Silent_p.G302G	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	302	Fibronectin type-III 4.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		ATCCCCCTGGCCACCTGTCTG	0.468000													74	109					0	0	0.048971	0	0
DMBT1	1755	broad.mit.edu	37	10	124390487	124390487	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:124390487G>C	ENST00000338354.3	+	46	5755	c.5649G>C	c.(5647-5649)ttG>ttC	p.L1883F	DMBT1_ENST00000368956.2_Missense_Mutation_p.L1255F|DMBT1_ENST00000368955.3_Missense_Mutation_p.L1873F|DMBT1_ENST00000344338.3_Missense_Mutation_p.L1873F|DMBT1_ENST00000359586.6_Missense_Mutation_p.L603F|DMBT1_ENST00000330163.4_Missense_Mutation_p.L1255F|DMBT1_ENST00000368909.3_Missense_Mutation_p.L1883F			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1883	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGCCACCTTGAGGTTGGTCA	0.483000													32	48					0	0	0.054565	0	0
PABPC1	26986	broad.mit.edu	37	8	101717279	101717279	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:101717279G>A	ENST00000318607.5	-	13	2821	c.1693C>T	c.(1693-1695)Cgg>Tgg	p.R565W	PABPC1_ENST00000519004.1_Missense_Mutation_p.R520W|PABPC1_ENST00000522387.1_Missense_Mutation_p.R533W	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	565	PABC.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			GGAAACAGCCGTTCACCTAGG	0.368000													26	124					0	0	0.050027	0	0
PSG11	5680	broad.mit.edu	37	19	43519365	43519365	+	Silent	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:43519365A>T	ENST00000401740.1	-	4	970	c.867T>A	c.(865-867)ccT>ccA	p.P289P	PSG11_ENST00000403486.1_Silent_p.P167P|PSG11_ENST00000306322.7_Silent_p.P167P|PSG11_ENST00000320078.7_Silent_p.P289P			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	289	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GAGTAATCTGAGGGATAAAGA	0.463000													97	253					0	0	0.048971	0	0
EMILIN3	90187	broad.mit.edu	37	20	39992303	39992303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:39992303G>T	ENST00000332312.3	-	3	681	c.489C>A	c.(487-489)taC>taA	p.Y163*		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	163						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CTGCTCTGCTGTAGGAAGGGG	0.652000													35	63					7.04047e-22	9.47595e-22	0.080422	1	0
SCN5A	6331	broad.mit.edu	37	3	38622698	38622698	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:38622698G>T	ENST00000413689.1	-	17	3145	c.2952C>A	c.(2950-2952)ctC>ctA	p.L984L	SCN5A_ENST00000425664.1_Silent_p.L984L|SCN5A_ENST00000414099.2_Silent_p.L984L|SCN5A_ENST00000333535.4_Silent_p.L984L|SCN5A_ENST00000443581.1_Silent_p.L984L|SCN5A_ENST00000423572.2_Silent_p.L984L|SCN5A_ENST00000455624.2_Silent_p.L984L|SCN5A_ENST00000451551.2_Silent_p.L984L|SCN5A_ENST00000450102.2_Silent_p.L984L|SCN5A_ENST00000449557.2_Silent_p.L984L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	984					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCTGCCGCAGGAGACCACAGC	0.667000													8	8					0.00307968	0.00316861	0.038147	1	0
QRFPR	84109	broad.mit.edu	37	4	122250803	122250803	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:122250803C>A	ENST00000394427.2	-	6	1373	c.962G>T	c.(961-963)gGa>gTa	p.G321V	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	321						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						GTTGGAAAATCCAATAATTTG	0.274000													14	33					6.31663e-08	6.91967e-08	0.024245	1	0
TBX2	6909	broad.mit.edu	37	17	59479175	59479175	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:59479175G>T	ENST00000240328.3	+	2	807	c.526G>T	c.(526-528)Ggc>Tgc	p.G176C	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	176				AGKA -> TDKT (in Ref. 4; AAB36216).	cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						GATGGTGGCGGGCAAGGCCGA	0.592000													8	14					0.00448238	0.00458395	0.047766	1	0
SEMA5A	9037	broad.mit.edu	37	5	9108286	9108286	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:9108286C>A	ENST00000382496.5	-	16	2704	c.2039G>T	c.(2038-2040)tGt>tTt	p.C680F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	680	TSP type-1 3.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CCCATTCTCACAGATCCTGCG	0.557000													9	23					0.000978159	0.00101101	0.080935	1	0
TEK	7010	broad.mit.edu	37	9	27197413	27197413	+	Silent	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:27197413T>C	ENST00000380036.4	+	12	2167	c.1725T>C	c.(1723-1725)taT>taC	p.Y575Y	TEK_ENST00000406359.4_Silent_p.Y532Y|TEK_ENST00000519097.1_Silent_p.Y428Y	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	575	Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ATGACTTTTATGTTGAAGTGG	0.433000													125	121					0	0	0.048971	0	0
TENM1	10178	broad.mit.edu	37	X	123785936	123785936	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chrX:123785936G>T	ENST00000422452.2	-	8	1470	c.1407C>A	c.(1405-1407)gtC>gtA	p.V469V	TENM1_ENST00000371130.3_Silent_p.V469V	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AGTCCTGCTTGACCAGCTGTT	0.423000													92	8					2.75442e-36	4.19987e-36	0.048971	1	0
CACNA1E	777	broad.mit.edu	37	1	181689367	181689367	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:181689367G>A	ENST00000526775.1	+	14	1942	c.1777G>A	c.(1777-1779)Gtg>Atg	p.V593M	CACNA1E_ENST00000357570.5_Missense_Mutation_p.V544M|CACNA1E_ENST00000360108.3_Missense_Mutation_p.V593M|CACNA1E_ENST00000367570.1_Missense_Mutation_p.V593M|CACNA1E_ENST00000358338.5_Missense_Mutation_p.V544M|CACNA1E_ENST00000367573.2_Missense_Mutation_p.V593M|CACNA1E_ENST00000367567.4_Missense_Mutation_p.V200M	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	593					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACGGAATTTGGTGGTCTCCTT	0.468000													36	62					0	0	0.069456	0	0
TLE3	7090	broad.mit.edu	37	15	70342448	70342448	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:70342448C>T	ENST00000558939.1	-	20	3684	c.2307G>A	c.(2305-2307)gaG>gaA	p.E769E	TLE3_ENST00000451782.2_Silent_p.E766E|TLE3_ENST00000317509.8_Silent_p.E757E|TLE3_ENST00000557997.1_Silent_p.E761E|TLE3_ENST00000558379.1_Silent_p.E764E|TLE3_ENST00000560589.1_Silent_p.E713E|TLE3_ENST00000559048.1_Silent_p.E769E|TLE3_ENST00000442299.2_Silent_p.E761E|TLE3_ENST00000558201.1_Silent_p.E775E|TLE3_ENST00000560939.1_Silent_p.E771E|TLE3_ENST00000559929.1_Silent_p.E779E|TLE3_ENST00000559191.1_Silent_p.E350E|TLE3_ENST00000440567.3_Silent_p.E759E|TLE3_ENST00000539550.1_Silent_p.E696E|TLE3_ENST00000557907.1_Silent_p.E761E			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	769					organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AGTAGATGACCTCATAAACTG	0.517000													64	107					0	0	0.048971	0	0
WDTC1	23038	broad.mit.edu	37	1	27621116	27621116	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:27621116A>G	ENST00000319394.3	+	9	1404	c.869A>G	c.(868-870)gAa>gGa	p.E290G	WDTC1_ENST00000361771.3_Missense_Mutation_p.E290G	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	290							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		ATGGGGGGGGAACAGGTATGT	0.532000													4	66					0	0	0.009096	0	0
ADAT3	113179	broad.mit.edu	37	19	1913034	1913034	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:1913034G>T	ENST00000329478.2	+	2	1208	c.988G>T	c.(988-990)Gac>Tac	p.D330Y	SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000316097.8_Intron|SCAMP4_ENST00000414057.2_Intron|ADAT3_ENST00000602400.1_Missense_Mutation_p.D314Y			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	314					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCTCGCCCGACGGCGCCCT	0.711000													7	24					0.00829132	0.00844094	0.069234	1	0
NEO1	4756	broad.mit.edu	37	15	73468860	73468860	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:73468860G>T	ENST00000339362.5	+	7	1579	c.1132G>T	c.(1132-1134)Ggg>Tgg	p.G378W	NEO1_ENST00000261908.6_Missense_Mutation_p.G378W|NEO1_ENST00000558964.1_Missense_Mutation_p.G378W|NEO1_ENST00000560262.1_Missense_Mutation_p.G378W			Q92859	NEO1_HUMAN	neogenin 1	378	Ig-like C2-type 4.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						GGTCAAAAATGGGGATATGGT	0.323000													30	48					9.65021e-13	1.14017e-12	0.045705	1	0
OR4K17	390436	broad.mit.edu	37	14	20586172	20586172	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:20586172A>T	ENST00000315543.4	+	1	607	c.607A>T	c.(607-609)Aat>Tat	p.N203Y		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTGTGGTCCCAATGTGGTAGA	0.438000													270	264					0	0	0.048971	0	0
KIF3A	11127	broad.mit.edu	37	5	132062049	132062049	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:132062049G>T	ENST00000378746.4	-	3	640	c.422C>A	c.(421-423)aCa>aAa	p.T141K	KIF3A_ENST00000403231.1_Missense_Mutation_p.T141K|KIF3A_ENST00000378735.1_Missense_Mutation_p.T141K	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	141	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTTTACCTTGTATCACCCTC	0.333000													52	107					4.32865e-36	6.58538e-36	0.048971	1	0
SH2D4B	387694	broad.mit.edu	37	10	82403749	82403749	+	Splice_Site	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:82403749G>C	ENST00000339284.2	+	7	1416	c.985_splice	c.e7-1	p.G329_splice	SH2D4B_ENST00000470604.2_Splice_Site_p.E402_splice|SH2D4B_ENST00000372150.3_3'UTR|SH2D4B_ENST00000313455.4_Splice_Site_p.G281_splice	NM_207372.2	NP_997255.2	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B	328	SH2.									endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)	13			Colorectal(32;0.229)			TCTGTTTTAGGAGGAAATTAT	0.388000													83	94					0	0	0.048971	0	0
SLC30A6	55676	broad.mit.edu	37	2	32418022	32418022	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:32418022C>A	ENST00000282587.5	+	7	438	c.401_splice	c.e7+1	p.T134_splice	SLC30A6_ENST00000406369.1_Splice_Site_p.T60_splice|SLC30A6_ENST00000357055.3_5'UTR|SLC30A6_ENST00000538303.1_Splice_Site_p.T105_splice|SLC30A6_ENST00000379343.2_Splice_Site_p.T174_splice|SLC30A6_ENST00000435660.1_Splice_Site_p.T134_splice	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	134						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GAGATACACACGTGAGATTTT	0.254000													3	2					1.23904e-05	1.30659e-05	0.014758	1	0
SNX2	6643	broad.mit.edu	37	5	122163148	122163148	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:122163148A>T	ENST00000379516.2	+	13	1539	c.1431A>T	c.(1429-1431)agA>agT	p.R477S	SNX2_ENST00000514949.1_Missense_Mutation_p.R360S|SNX2_ENST00000510372.1_3'UTR	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	477					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		AAGTGGGAAGATTTGAGGCAT	0.323000													60	82					0	0	0.048971	0	0
POM121L12	285877	broad.mit.edu	37	7	53103588	53103588	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:53103588C>A	ENST00000408890.4	+	1	240	c.224C>A	c.(223-225)aCc>aAc	p.T75N		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	75										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GTGCCCAGCACCCACCTCATC	0.706000													18	33					1.22574e-08	1.36037e-08	0.069288	1	0
MUC17	140453	broad.mit.edu	37	7	100696652	100696652	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:100696652G>A	ENST00000306151.4	+	11	13362	c.13298G>A	c.(13297-13299)tGg>tAg	p.W4433*		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4433						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TTATACAAGTGGCAAGAAGAG	0.478000													66	66					0	0	0.048971	0	0
OR2C3	81472	broad.mit.edu	37	1	247695285	247695285	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:247695285G>T	ENST00000366487.3	-	2	890	c.529C>A	c.(529-531)Cac>Aac	p.H177N	GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527084.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CAAAAGAAGTGGTCGATGCAA	0.552000													22	31					1.1804e-14	1.43987e-14	0.091800	1	0
CDHR3	222256	broad.mit.edu	37	7	105656440	105656440	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:105656440C>T	ENST00000542731.1	+	11	1503	c.1395C>T	c.(1393-1395)tcC>tcT	p.S465S	CDHR3_ENST00000343407.5_Silent_p.S184S|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000478080.1_Silent_p.S377S|CDHR3_ENST00000317716.9_Silent_p.S465S			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	465	Cadherin 4.|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						ATAGGCCATCCTATGTATTTG	0.393000													26	30					0	0	0.037714	0	0
MADD	8567	broad.mit.edu	37	11	47317082	47317082	+	Silent	SNP	A	A	T	rs143711042	by1000genomes	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:47317082A>T	ENST00000342922.4	+	21	3795	c.3438A>T	c.(3436-3438)ccA>ccT	p.P1146P	MADD_ENST00000407859.3_Silent_p.P1123P|MADD_ENST00000395336.3_Silent_p.P1184P|MADD_ENST00000402799.1_Silent_p.P1103P|MADD_ENST00000405573.2_5'UTR|MADD_ENST00000406482.1_Silent_p.P1103P|MADD_ENST00000402192.2_Silent_p.P1146P|MADD_ENST00000395344.3_Silent_p.P1103P|MADD_ENST00000311027.5_Silent_p.P1184P|MADD_ENST00000349238.3_Silent_p.P1166P	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1184					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GCGTGAGTCCAGCTGTTATGA	0.512000													36	76					0	0	0.080422	0	0
ASB13	79754	broad.mit.edu	37	10	5683788	5683788	+	Silent	SNP	C	C	T	rs149225019	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:5683788C>T	ENST00000357700.6	-	5	680	c.654G>A	c.(652-654)ccG>ccA	p.P218P	ASB13_ENST00000479033.1_5'UTR	NM_024701.3	NP_078977.2	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box containing 13	218					intracellular signal transduction		protein binding			NS(1)|endometrium(3)|lung(3)|ovary(1)	8				GBM - Glioblastoma multiforme(2;9.59e-09)		TGTAGTCAGACGGCTTCTTCC	0.602000													7	22					0	0	0.047766	0	0
CDH23	64072	broad.mit.edu	37	10	73553269	73553269	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:73553269A>G	ENST00000224721.6	+	47	6604	c.6599A>G	c.(6598-6600)aAt>aGt	p.N2200S		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2195	Cadherin 21.			EFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVG IVAKDDTDRLVPNQEDAFAVNIN -> ASWEGQSHVTQAYE EAVGPPQPQVPDSTGDRHPLWGLGGFGQEHPWEGQILGGSS QAEPGLVWS (in Ref. 6; BAB61902).	calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTCATTGCCAATATCACGGCC	0.562000													28	52					0	0	0.069456	0	0
MYO1F	4542	broad.mit.edu	37	19	8601852	8601852	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:8601852G>T	ENST00000338257.8	-	17	2047	c.1780C>A	c.(1780-1782)Cga>Aga	p.R594R		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	594	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.R594*(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TCCCAGTCTCGGGGCCTCTTG	0.577000													14	20					2.39556e-15	2.97577e-15	0.076483	1	0
BCMO1	53630	broad.mit.edu	37	16	81324046	81324046	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:81324046C>G	ENST00000258168.2	+	11	1969	c.1508C>G	c.(1507-1509)gCc>gGc	p.A503G	BCMO1_ENST00000425577.2_Missense_Mutation_p.A434G	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	503					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						TTGGCCCGTGCCTCTGTTGAT	0.473000													80	21					0	0	0.048971	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23444035	23444035	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:23444035G>T	ENST00000526079.1	+	0	1679					NR_027407.1|NR_033350.1																						TGGACAGTGAGGGGGAGGAGG	0.617000													10	56					5.50884e-06	5.83644e-06	0.093190	1	0
CPPED1	55313	broad.mit.edu	37	16	12798851	12798851	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:12798851C>A	ENST00000381774.4	-	3	585	c.345G>T	c.(343-345)gtG>gtT	p.V115V	CPPED1_ENST00000433677.2_Intron|CPPED1_ENST00000261660.4_Intron	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	115							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						TGGCCCTGTCCACTGCCCTAA	0.622000													46	11					7.88023e-25	1.08654e-24	0.048971	1	0
CHSY3	337876	broad.mit.edu	37	5	129521158	129521158	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:129521158T>C	ENST00000305031.4	+	3	2681	c.2323T>C	c.(2323-2325)Tgg>Cgg	p.W775R		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	775						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GACTGGATTTTGGAGAGACTA	0.413000													100	145					0	0	0.048971	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7671671	7671671	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:7671671G>T	ENST00000446248.2	+	5	731	c.630G>T	c.(628-630)acG>acT	p.T210T	CAMSAP3_ENST00000160298.4_Intron	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	207	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						AGTGCCCTACGCGCTGGTACT	0.612000													12	4					2.61681e-11	3.05445e-11	0.020292	1	0
RELN	5649	broad.mit.edu	37	7	103294653	103294653	+	Splice_Site	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:103294653C>G	ENST00000428762.1	-	13	1601		c.e13-1		RELN_ENST00000343529.5_Splice_Site|RELN_ENST00000424685.2_Splice_Site	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAAATTCCTCCTGCACAAAAC	0.318000													96	127					0	0	0.048971	0	0
SOAT1	6646	broad.mit.edu	37	1	179320569	179320569	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:179320569A>G	ENST00000367619.3	+	15	1711	c.1568A>G	c.(1567-1569)tAt>tGt	p.Y523C	SOAT1_ENST00000540564.1_Missense_Mutation_p.Y465C|SOAT1_ENST00000539888.1_Missense_Mutation_p.Y458C|SOAT1_ENST00000535686.1_Missense_Mutation_p.Y259C	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	523					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	CAAGAATGGTATGCACGTCAG	0.428000													224	296					0	0	0.048971	0	0
CDHR3	222256	broad.mit.edu	37	7	105656441	105656441	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:105656441T>A	ENST00000542731.1	+	11	1504	c.1396T>A	c.(1396-1398)Tat>Aat	p.Y466N	CDHR3_ENST00000343407.5_Missense_Mutation_p.Y185N|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000478080.1_Missense_Mutation_p.Y378N|CDHR3_ENST00000317716.9_Missense_Mutation_p.Y466N			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	466	Cadherin 4.|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						TAGGCCATCCTATGTATTTGA	0.393000													24	30					0	0	0.030593	0	0
SART3	9733	broad.mit.edu	37	12	108954775	108954775	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:108954775C>A	ENST00000228284.3	-	1	390	c.156G>T	c.(154-156)ggG>ggT	p.G52G	SART3_ENST00000546611.1_Silent_p.G52G|SART3_ENST00000431469.2_Silent_p.G52G|SART3_ENST00000552221.1_5'UTR	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	52					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						CCCACGCTGGCCCCATGGTCT	0.642000									Porokeratosis				12	31					3.27435e-08	3.60445e-08	0.020292	1	0
COL6A3	1293	broad.mit.edu	37	2	238263564	238263564	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:238263564C>T	ENST00000295550.4	-	24	7057	c.6605G>A	c.(6604-6606)cGa>cAa	p.R2202Q	COL6A3_ENST00000353578.4_Missense_Mutation_p.R1996Q|COL6A3_ENST00000347401.3_Missense_Mutation_p.R2001Q|COL6A3_ENST00000346358.4_Missense_Mutation_p.R2002Q|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1996Q|COL6A3_ENST00000472056.1_Missense_Mutation_p.R1595Q	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2202	Collagen-like 3.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R2202Q(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGGTCCCCTTCGGCCAAAGCC	0.592000													11	36					0	0	0.080935	0	0
SLC25A41	284427	broad.mit.edu	37	19	6430113	6430113	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:6430113C>G	ENST00000321510.6	-	3	491	c.423G>C	c.(421-423)caG>caC	p.Q141H		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	141					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						AGCCGCCCTCCTGGACCATGC	0.622000													14	10					0	0	0.020292	0	0
IQGAP2	10788	broad.mit.edu	37	5	75979002	75979002	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:75979002G>T	ENST00000274364.6	+	29	4020	c.3723G>T	c.(3721-3723)ctG>ctT	p.L1241L	IQGAP2_ENST00000396234.3_Silent_p.L737L|IQGAP2_ENST00000502745.1_Silent_p.L737L|IQGAP2_ENST00000379730.3_Silent_p.L743L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1241					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GTGAATTGCTGGGGTCGCTGG	0.443000													97	195					5.07675e-46	8.16379e-46	0.048971	1	0
BANK1	55024	broad.mit.edu	37	4	102992455	102992455	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:102992455C>A	ENST00000504592.1	+	18	2609	c.2191C>A	c.(2191-2193)Cca>Aca	p.P731T	BANK1_ENST00000508653.1_Missense_Mutation_p.P613T|BANK1_ENST00000428908.1_Missense_Mutation_p.P613T|BANK1_ENST00000444316.2_Missense_Mutation_p.P716T|BANK1_ENST00000322953.4_Missense_Mutation_p.P746T			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	746					B cell activation			p.P746S(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TGTGCACCATCCAGGTGGTAA	0.294000													74	143					1.50979e-27	2.13834e-27	0.048971	1	0
ERN1	2081	broad.mit.edu	37	17	62135165	62135165	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:62135165G>A	ENST00000433197.2	-	12	1490	c.1395C>T	c.(1393-1395)ccC>ccT	p.P465P		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	465					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						GCTTTACCAGGGGATAGGTGA	0.547000													11	77					0	0	0.069234	0	0
OVOL1	5017	broad.mit.edu	37	11	65561659	65561659	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:65561659C>A	ENST00000335987.3	+	2	610	c.258C>A	c.(256-258)gaC>gaA	p.D86E	OVOL1_ENST00000532448.1_Missense_Mutation_p.D24E	NM_004561.3	NP_004552.2	O14753	OVOL1_HUMAN	ovo-like zinc finger 1	86					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6				READ - Rectum adenocarcinoma(159;0.17)		CCTCTGAAGACATGGGCCACT	0.637000													35	51					5.43694e-19	7.05135e-19	0.080422	1	0
RASGRP1	10125	broad.mit.edu	37	15	38800034	38800034	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr15:38800034T>C	ENST00000310803.5	-	9	1312	c.1135A>G	c.(1135-1137)Aac>Gac	p.N379D	RASGRP1_ENST00000450598.2_Missense_Mutation_p.N379D|RASGRP1_ENST00000559830.1_Missense_Mutation_p.N379D|RASGRP1_ENST00000539159.1_Missense_Mutation_p.N331D|RASGRP1_ENST00000561180.1_Missense_Mutation_p.N430D|RASGRP1_ENST00000558164.1_Missense_Mutation_p.N379D	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	379	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTATGGACGTTCACTTTCCCG	0.512000													18	15					0	0	0.062417	0	0
USP36	57602	broad.mit.edu	37	17	76802278	76802278	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:76802278G>A	ENST00000312010.6	-	15	2500	c.2176C>T	c.(2176-2178)Cac>Tac	p.H726Y	USP36_ENST00000542802.2_Missense_Mutation_p.H726Y|USP36_ENST00000449938.2_Missense_Mutation_p.H426Y	NM_025090.3	NP_079366.3	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	726					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			ACGACGGGGTGAGAGGTTTTC	0.622000													40	65					0	0	0.045515	0	0
ENPP2	5168	broad.mit.edu	37	8	120592356	120592356	+	Splice_Site	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:120592356C>G	ENST00000427067.2	-	19	1948	c.1768_splice	c.e19+1	p.A590_splice	ENPP2_ENST00000522167.1_Splice_Site_p.E229_splice|ENPP2_ENST00000522826.1_Splice_Site_p.A594_splice|ENPP2_ENST00000075322.6_Splice_Site_p.E594_splice|ENPP2_ENST00000259486.6_Splice_Site_p.E646_splice			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	593					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CACCCCTTACCTTCTGTAGAC	0.338000													298	426					0	0	0.048971	0	0
LRP2	4036	broad.mit.edu	37	2	170097780	170097780	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:170097780C>A	ENST00000263816.3	-	25	4048	c.3763G>T	c.(3763-3765)Gac>Tac	p.D1255Y	LRP2_ENST00000443831.1_Missense_Mutation_p.D1118Y	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1255	LDL-receptor class A 13.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TAGAGGCAGTCTGGATGCCCA	0.502000													128	117					1.01513e-52	1.68855e-52	0.048971	1	0
ABCA4	24	broad.mit.edu	37	1	94481334	94481334	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:94481334T>G	ENST00000370225.3	-	37	5359	c.5273A>C	c.(5272-5274)gAa>gCa	p.E1758A	ABCA4_ENST00000536513.1_Missense_Mutation_p.E28A	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1758					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGGAAGGTTTTCTGGAGAAGT	0.537000													32	40					0	0	0.054565	0	0
SETD2	29072	broad.mit.edu	37	3	47098321	47098321	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:47098321G>A	ENST00000409792.3	-	15	6995	c.6953C>T	c.(6952-6954)cCa>cTa	p.P2318L		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2318	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTGTACAATTGGTGGAGTTGT	0.403000			"""N, F, S, Mis"""		clear cell renal carcinoma								55	78					0	0	0.048971	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126276453	126276453	+	Splice_Site	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:126276453G>T	ENST00000526727.1	+	2	475		c.e2+1		ST3GAL4_ENST00000534083.1_Splice_Site|ST3GAL4_ENST00000534457.1_Intron|ST3GAL4_ENST00000532243.1_Splice_Site|ST3GAL4_ENST00000227495.6_Intron|ST3GAL4_ENST00000530591.1_Intron|ST3GAL4_ENST00000526756.1_Splice_Site|ST3GAL4_ENST00000449406.2_Splice_Site|ST3GAL4_ENST00000444328.2_Splice_Site|ST3GAL4_ENST00000392669.2_Splice_Site|ST3GAL4_ENST00000356132.4_Splice_Site			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4						post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		ACATCGAGCTGTGAGTTCACC	0.577000													58	55					3.00063e-23	4.07916e-23	0.048971	1	0
C2orf71	388939	broad.mit.edu	37	2	29294984	29294984	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:29294984G>T	ENST00000331664.5	-	1	2143	c.2144C>A	c.(2143-2145)gCc>gAc	p.A715D		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	715					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TGTGGCCTTGGCAGCCTCACT	0.527000													80	54					5.56898e-48	9.06297e-48	0.048971	1	0
BICC1	80114	broad.mit.edu	37	10	60461881	60461881	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:60461881G>T	ENST00000373886.3	+	3	289	c.285G>T	c.(283-285)aaG>aaT	p.K95N		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	95					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						CAAAACTGAAGATCGGAGCCA	0.368000													29	40					2.70662e-09	3.04382e-09	0.041601	1	0
NCK1	4690	broad.mit.edu	37	3	136664548	136664548	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr3:136664548A>G	ENST00000469404.1	+	2	249	c.158A>G	c.(157-159)tAc>tGc	p.Y53C	NCK1_ENST00000481752.1_Missense_Mutation_p.Y117C|NCK1_ENST00000288986.2_Missense_Mutation_p.Y117C	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	117	SH3 1.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						AAATTTAACTACATGGCTGAG	0.463000													144	202					0	0	0.048971	0	0
GPR148	344561	broad.mit.edu	37	2	131487498	131487498	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:131487498G>T	ENST00000309926.4	+	1	856	c.774G>T	c.(772-774)cgG>cgT	p.R258R		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	258						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					GCTATTCCCGGGCCAGGGGCA	0.572000													84	177					1.6246e-59	2.7915e-59	0.048971	1	0
TPD52L2	7165	broad.mit.edu	37	20	62521253	62521253	+	Silent	SNP	A	A	T	rs149447981	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:62521253A>T	ENST00000217121.5	+	9	717	c.645A>T	c.(643-645)tcA>tcT	p.S215S	TPD52L2_ENST00000351424.4_Silent_p.S195S|TPD52L2_ENST00000369927.4_Silent_p.S149S|TPD52L2_ENST00000346249.4_Silent_p.S192S|TPD52L2_ENST00000358548.4_Silent_p.S186S|TPD52L2_ENST00000352482.4_Silent_p.S206S|TPD52L2_ENST00000348257.5_Silent_p.S172S	NM_199360.2	NP_955392.1	O43399	TPD54_HUMAN	tumor protein D52-like 2	192					regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					TCCCTTCCTCAGCGGGGAGTG	0.547000													6	25					0	0	0.058154	0	0
RSAD2	91543	broad.mit.edu	37	2	7035938	7035938	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:7035938G>T	ENST00000382040.3	+	6	1087	c.951G>T	c.(949-951)cgG>cgT	p.R317R	RSAD2_ENST00000541728.1_Silent_p.R210R	NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	317					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GAAAGGGACGGAAGGACCCTT	0.378000													46	86					1.00776e-21	1.34832e-21	0.048971	1	0
DCD	117159	broad.mit.edu	37	12	55040935	55040935	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:55040935C>G	ENST00000456047.2	-	2	256	c.67G>C	c.(67-69)Gag>Cag	p.E23Q	DCD_ENST00000293371.6_Missense_Mutation_p.E23Q			P81605	DCD_HUMAN	dermcidin	23					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				GAGGCGGCCTCTGGATCATCT	0.567000													16	13					0	0	0.038395	0	0
HSPA6	3310	broad.mit.edu	37	1	161495987	161495987	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:161495987C>T	ENST00000309758.4	+	1	1952	c.1539C>T	c.(1537-1539)agC>agT	p.S513S		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	513					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCGGCTGAGCAAGGAGGAGG	0.557000													22	36					0	0	0.055883	0	0
ACTG2	72	broad.mit.edu	37	2	74135818	74135818	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:74135818T>C	ENST00000409624.1	+	5	917	c.274T>C	c.(274-276)Tac>Cac	p.Y92H	ACTG2_ENST00000409731.3_Missense_Mutation_p.Y49H|ACTG2_ENST00000345517.3_Missense_Mutation_p.Y92H			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	92					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						CCACTCCTTCTACAATGAGCT	0.522000													33	34					0	0	0.059317	0	0
TRAV9-2	28677	broad.mit.edu	37	14	22409354	22409354	+	RNA	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:22409354G>C	ENST00000390441.2	+	0	42																											CCATTATTTGGGTAACACACT	0.398000													19	30					0	0	0.049695	0	0
PARD3B	117583	broad.mit.edu	37	2	206023618	206023618	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:206023618G>T	ENST00000406610.2	+	11	1814	c.1607G>T	c.(1606-1608)gGc>gTc	p.G536V	PARD3B_ENST00000358768.2_Intron|PARD3B_ENST00000349953.3_Missense_Mutation_p.G536V|PARD3B_ENST00000462231.1_Missense_Mutation_p.G536V|PARD3B_ENST00000351153.1_Missense_Mutation_p.G536V	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	536	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ATTCATGGAGGCGCTGCTTTT	0.443000													33	76					8.53417e-09	9.48709e-09	0.054565	1	0
ANKRD24	170961	broad.mit.edu	37	19	4218088	4218088	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:4218088C>T	ENST00000600132.1	+	18	3207	c.2931C>T	c.(2929-2931)aaC>aaT	p.N977N	ANKRD24_ENST00000262970.5_Silent_p.N1067N|ANKRD24_ENST00000318934.4_Silent_p.N977N	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	977										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGCAGGCCAACGTGGCCCAGC	0.716000													5	10					0	0	0.021553	0	0
LCP2	3937	broad.mit.edu	37	5	169677861	169677861	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:169677861G>A	ENST00000046794.5	-	20	1967	c.1352C>T	c.(1351-1353)tCt>tTt	p.S451F	LCP2_ENST00000521416.1_Missense_Mutation_p.S246F|C5orf58_ENST00000517575.1_Intron	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	451	SH2.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		TGTTTTTTTAGAGCTGTCTCT	0.353000													38	55					0	0	0.092188	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43481636	43481636	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:43481636C>A	ENST00000376922.2	-	6	888	c.456_splice	c.e6+1	p.R152_splice	ARHGAP27_ENST00000442348.1_Splice_Site_p.R466_splice|ARHGAP27_ENST00000532038.1_Intron|ARHGAP27_ENST00000528384.1_Splice_Site_p.R125_splice|ARHGAP27_ENST00000455881.1_Splice_Site_p.R152_splice|ARHGAP27_ENST00000532891.2_Intron|ARHGAP27_ENST00000428638.1_Splice_Site_p.R493_splice	NM_199282.2	NP_954976.1	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	493					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					GATGCCTACCCTCACAGCAGC	0.617000													29	59					3.05275e-18	3.93659e-18	0.045515	1	0
STOX2	56977	broad.mit.edu	37	4	184938371	184938371	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:184938371G>T	ENST00000308497.4	+	4	4150	c.2715G>T	c.(2713-2715)ccG>ccT	p.P905P		NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	905					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CGGAGCCCCCGACAAATGAAG	0.537000													11	14					6.42651e-13	7.64631e-13	0.080935	1	0
ZNF536	9745	broad.mit.edu	37	19	30935852	30935852	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:30935852G>T	ENST00000355537.3	+	2	1530	c.1383G>T	c.(1381-1383)aaG>aaT	p.K461N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGCCCATGAAGGAGAAGGAAG	0.647000													67	45					9.0989e-53	1.52098e-52	0.048971	1	0
PYGL	5836	broad.mit.edu	37	14	51378963	51378963	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr14:51378963G>C	ENST00000216392.7	-	14	2011	c.1679C>G	c.(1678-1680)cCa>cGa	p.P560R	PYGL_ENST00000532462.1_Missense_Mutation_p.P560R|PYGL_ENST00000544180.2_Missense_Mutation_p.P526R|RP11-218E20.5_ENST00000557343.1_RNA	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	560					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CATGGAGGATGGGTTGATCTT	0.473000													152	126					0	0	0.048971	0	0
VPS13D	55187	broad.mit.edu	37	1	12304475	12304475	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:12304475C>T	ENST00000358136.3	+	4	478	c.348C>T	c.(346-348)gcC>gcT	p.A116A	VPS13D_ENST00000356315.4_Silent_p.A116A	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	116					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TACTTCAAGCCCTGGAGGAGA	0.458000													76	107					0	0	0.048971	0	0
UGT1A1	54658	broad.mit.edu	37	2	234676544	234676544	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:234676544C>A	ENST00000360418.3	+	3	1046	c.1046C>A	c.(1045-1047)aCg>aAg	p.T349K	UGT1A9_ENST00000354728.4_Missense_Mutation_p.T346K|UGT1A10_ENST00000344644.5_Missense_Mutation_p.T346K|UGT1A6_ENST00000305139.6_Missense_Mutation_p.T348K|UGT1A6_ENST00000406651.1_Missense_Mutation_p.T81K|UGT1A6_ENST00000373424.1_Missense_Mutation_p.T81K|UGT1A7_ENST00000373426.3_Missense_Mutation_p.T346K|UGT1A10_ENST00000373445.1_Missense_Mutation_p.T346K|UGT1A5_ENST00000373414.3_Missense_Mutation_p.T350K|UGT1A4_ENST00000373409.3_Missense_Mutation_p.T350K|UGT1A3_ENST00000482026.1_Missense_Mutation_p.T350K|UGT1A1_ENST00000305208.5_Missense_Mutation_p.T349K|UGT1A8_ENST00000373450.4_Missense_Mutation_p.T346K			P22309	UD11_HUMAN		349					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GCGAACAACACGATACTTGTT	0.453000													39	136					1.00953e-15	1.26565e-15	0.045515	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52926896	52926896	+	Splice_Site	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:52926896C>A	ENST00000371544.3	-	19	3494		c.e19-1		ZCCHC11_ENST00000257177.4_Splice_Site	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TATGTTGAGCCTGAAAAATAA	0.274000													36	53					1.06647e-15	1.33457e-15	0.064281	1	0
GPR98	84059	broad.mit.edu	37	5	90085636	90085636	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:90085636A>T	ENST00000405460.2	+	69	14107	c.14011A>T	c.(14011-14013)Aga>Tga	p.R4671*	GPR98_ENST00000425867.2_Nonsense_Mutation_p.R332*	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4671					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTCTTTGTCAGAAGAGTCAA	0.428000													3	0					0	0	0.009096	0	0
AIM1	202	broad.mit.edu	37	6	106987390	106987390	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:106987390C>T	ENST00000369066.3	+	7	4094	c.3607C>T	c.(3607-3609)Cgg>Tgg	p.R1203W		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1203	Beta/gamma crystallin 'Greek key' 4.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TGGATCCATGCGGCCTCTGAA	0.438000													5	274					0	0	0.021553	0	0
LIG1	3978	broad.mit.edu	37	19	48643258	48643258	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:48643258C>A	ENST00000263274.7	-	12	1476	c.1057G>T	c.(1057-1059)Gtc>Ttc	p.V353F	LIG1_ENST00000427526.2_Missense_Mutation_p.V322F|LIG1_ENST00000536218.1_Missense_Mutation_p.V285F	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	353					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	TTGAGAAGGACACCATCACCC	0.632000								Nucleotide excision repair (NER)					72	66					8.87156e-34	1.32001e-33	0.048971	1	0
GLI3	2737	broad.mit.edu	37	7	42004046	42004046	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:42004046C>A	ENST00000395925.3	-	15	4709	c.4625G>T	c.(4624-4626)cGg>cTg	p.R1542L	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1542					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GAGGGACGCCCGAGGCGTGGT	0.577000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				35	50					3.4345e-17	4.37882e-17	0.042209	1	0
RNF213	57674	broad.mit.edu	37	17	78320202	78320202	+	Silent	SNP	C	C	T	rs143580800	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr17:78320202C>T	ENST00000582970.1	+	29	8210	c.8067C>T	c.(8065-8067)atC>atT	p.I2689I	RNF213_ENST00000336301.6_Silent_p.I762I|RNF213_ENST00000508628.2_Silent_p.I2738I	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCTGGCCATCGGGGTGTGTT	0.522000													25	64					0	0	0.076483	0	0
TLR6	10333	broad.mit.edu	37	4	38829072	38829072	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr4:38829072C>A	ENST00000436693.2	-	2	2142	c.2023G>T	c.(2023-2025)Gag>Tag	p.E675*	TLR6_ENST00000381950.1_Nonsense_Mutation_p.E675*	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	675	TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAGTTTCTCTCATGAAGACAA	0.368000													107	115					6.28223e-41	9.86791e-41	0.048971	1	0
AC096579.13	0	broad.mit.edu	37	2	89156777	89156777	+	RNA	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:89156777G>T	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							CTGGAGGACCGCAATAGGGGT	0.522000													10	24					0.00621372	0.00633537	0.058154	1	0
FZD5	7855	broad.mit.edu	37	2	208632887	208632887	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:208632887G>C	ENST00000295417.3	-	2	1130	c.577C>G	c.(577-579)Cgc>Ggc	p.R193G		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	193					angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		AAGGGCTCGCGACACTTGCAC	0.701000													7	22					0	0	0.029380	0	0
ZNF268	10795	broad.mit.edu	37	12	133764456	133764456	+	Splice_Site	SNP	A	A	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:133764456A>T	ENST00000536435.2	+	3	363		c.e3-1		ZNF268_ENST00000541009.2_Splice_Site|ZNF268_ENST00000542986.2_Splice_Site|ZNF268_ENST00000539248.2_Splice_Site|CTD-2140B24.4_ENST00000540096.2_Splice_Site|ZNF268_ENST00000541211.2_Splice_Site|ZNF268_ENST00000542711.2_Intron|ZNF268_ENST00000416488.1_Splice_Site|ZNF268_ENST00000228289.5_Splice_Site|ZNF268_ENST00000592241.1_Intron|ZNF268_ENST00000537565.1_Intron|ZNF268_ENST00000536899.2_Intron	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TTGAGTCCACAGGTCCCACCT	0.453000													3	46					0	0	0.004672	0	0
NOL6	65083	broad.mit.edu	37	9	33462736	33462736	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:33462736G>C	ENST00000455041.2	-	25	3270	c.3211C>G	c.(3211-3213)Ctg>Gtg	p.L1071V	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000379471.2_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	1123					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AAGTCCTCCAGGATTGCTTCA	0.567000													62	63					0	0	0.048971	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590240	140590240	+	Silent	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:140590240C>A	ENST00000239450.2	+	1	1950	c.1761C>A	c.(1759-1761)acC>acA	p.T587T	PCDHB12_ENST00000541609.1_Silent_p.T250T	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		587	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGGTGACCAAGGTGGTGG	0.697000													15	141					1.77063e-15	2.20758e-15	0.108266	1	0
BTBD11	121551	broad.mit.edu	37	12	107937716	107937716	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:107937716C>A	ENST00000280758.5	+	3	1818	c.1290C>A	c.(1288-1290)gaC>gaA	p.D430E	BTBD11_ENST00000490090.2_Missense_Mutation_p.D430E|BTBD11_ENST00000420571.2_Missense_Mutation_p.D430E	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	430						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CCACAGGTGACCTGGTGTCCC	0.572000													24	44					1.1804e-14	1.43987e-14	0.091800	1	0
DDX11	1663	broad.mit.edu	37	12	31256895	31256895	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:31256895G>T	ENST00000407793.2	+	27	3092	c.2841G>T	c.(2839-2841)tgG>tgT	p.W947C	DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_3'UTR|DDX11_ENST00000545668.1_Missense_Mutation_p.W947C|DDX11_ENST00000350437.4_3'UTR	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	947					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GGAGAGTGTGGAGTCCAGAGT	0.602000										Multiple Myeloma(12;0.14)			15	18					1.05317e-09	1.1923e-09	0.020292	1	0
PXDN	7837	broad.mit.edu	37	2	1653092	1653092	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:1653092C>A	ENST00000252804.4	-	17	2510	c.2460G>T	c.(2458-2460)caG>caT	p.Q820H		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	820					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACTGGCCCCACTGCATCAGCA	0.657000													30	20					3.1745e-13	3.79706e-13	0.037714	1	0
COL4A4	1286	broad.mit.edu	37	2	227872247	227872247	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:227872247G>T	ENST00000396625.3	-	48	5074	c.4867C>A	c.(4867-4869)Ctg>Atg	p.L1623M	COL4A4_ENST00000329662.7_Missense_Mutation_p.L1620M	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1623	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AAATCTTCCAGGCAGCTGCCA	0.532000													37	86					8.69298e-16	1.09186e-15	0.092188	1	0
NR2F1	7025	broad.mit.edu	37	5	92921132	92921132	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:92921132C>A	ENST00000327111.3	+	1	2090	c.403C>A	c.(403-405)Cgc>Agc	p.R135S	NR2F1-AS1_ENST00000513055.1_RNA	NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	135					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CCAGCACCACCGCAACCAGTG	0.562000													17	24					3.52763e-06	3.75504e-06	0.033300	1	0
TRBV5-4	28611	broad.mit.edu	37	7	142168646	142168646	+	RNA	SNP	C	C	T	rs35534131		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:142168646C>T	ENST00000454561.2	-	0	277																											GTGTGTGGGACTTTGGGTGAC	0.552000													35	72					0	0	0.048971	0	0
ANK3	288	broad.mit.edu	37	10	61829123	61829123	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr10:61829123C>A	ENST00000280772.1	-	37	11707	c.11516G>T	c.(11515-11517)tGt>tTt	p.C3839F	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3839					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATCTCTTACACAGTGTCCTTG	0.408000													211	346					6.85672e-94	1.22804e-93	0.048971	1	0
CRB1	23418	broad.mit.edu	37	1	197404099	197404099	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:197404099G>T	ENST00000367397.1	+	5	2107	c.1249G>T	c.(1249-1251)Gaa>Taa	p.E417*	CRB1_ENST00000535699.1_Nonsense_Mutation_p.E1012*|CRB1_ENST00000367399.2_Nonsense_Mutation_p.E924*|CRB1_ENST00000367400.3_Nonsense_Mutation_p.E1036*|CRB1_ENST00000544212.1_Nonsense_Mutation_p.E517*|CRB1_ENST00000538660.1_Intron			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1036	EGF-like 10; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CACATGGCACGAAGTGACCCT	0.453000													64	93					6.8682e-38	1.06159e-37	0.048971	1	0
U2AF1L4	199746	broad.mit.edu	37	19	36233706	36233706	+	Splice_Site	SNP	T	T	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:36233706T>A	ENST00000412391.2	-	8	592		c.e8-2		U2AF1L4_ENST00000378975.3_Splice_Site|U2AF1L4_ENST00000292879.5_Splice_Site|AD000671.6_ENST00000589807.1_Intron			Q8WU68	U2AF4_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 4						mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGGGTGACCTGGGAATAGGA	0.612000													28	66					0	0	0.108266	0	0
CYFIP2	26999	broad.mit.edu	37	5	156787323	156787323	+	Silent	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:156787323C>T	ENST00000347377.6	+	25	3282	c.2851C>T	c.(2851-2853)Ctg>Ttg	p.L951L	CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000522463.1_Silent_p.L755L|CYFIP2_ENST00000377576.3_Silent_p.L951L|CYFIP2_ENST00000541131.1_Silent_p.L876L|CYFIP2_ENST00000521420.1_Silent_p.L925L|CYFIP2_ENST00000318218.6_Silent_p.L976L|CYFIP2_ENST00000435847.2_Silent_p.L650L	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	976					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTGAAAACACTGATAGAGGT	0.512000													64	99					0	0	0.048971	0	0
LEFTY1	10637	broad.mit.edu	37	1	226076566	226076566	+	Silent	SNP	G	G	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:226076566G>A	ENST00000272134.5	-	1	280	c.201C>T	c.(199-201)cgC>cgT	p.R67R	LEFTY1_ENST00000492457.1_Intron|RP4-559A3.7_ENST00000432920.2_Intron	NM_020997.3	NP_066277.1	O75610	LFTY1_HUMAN	left-right determination factor 1	67					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					CCCCGTGGCTGCGCTGCAGCA	0.677000													16	14					0	0	0.024245	0	0
FLI1	2313	broad.mit.edu	37	11	128680554	128680554	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:128680554G>T	ENST00000344954.6	+	9	1319	c.931G>T	c.(931-933)Gat>Tat	p.D311Y	FLI1_ENST00000534087.1_Missense_Mutation_p.D311Y|FLI1_ENST00000281428.8_Missense_Mutation_p.D278Y|FLI1_ENST00000429175.2_Missense_Mutation_p.D344Y|FLI1_ENST00000525560.1_Missense_Mutation_p.D151Y			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	344					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		TTATTACTATGATAAAAACAT	0.527000			T	EWSR1	Ewing sarcoma								37	29					1.36161e-19	1.77613e-19	0.069456	1	0
USP5	8078	broad.mit.edu	37	12	6965284	6965284	+	Silent	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:6965284G>T	ENST00000229268.8	+	4	460	c.408G>T	c.(406-408)ctG>ctT	p.L136L	USP5_ENST00000389231.5_Silent_p.L136L	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	136					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						GGGATGGACTGGGGGGACTGC	0.507000													90	16					8.55712e-49	1.40611e-48	0.048971	1	0
ANKLE2	23141	broad.mit.edu	37	12	133306845	133306845	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:133306845T>C	ENST00000539605.1	-	10	8401	c.1717A>G	c.(1717-1719)Att>Gtt	p.I573V	ANKLE2_ENST00000542374.1_Intron|ANKLE2_ENST00000542657.1_5'UTR|ANKLE2_ENST00000357997.5_Missense_Mutation_p.I635V|ANKLE2_ENST00000542282.1_5'UTR			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	635						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CTCACGGAAATGGAATTGCTG	0.527000													5	4					0	0	0.021553	0	0
LMF2	91289	broad.mit.edu	37	22	50944120	50944120	+	Missense_Mutation	SNP	C	C	A	rs113089468	byFrequency	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr22:50944120C>A	ENST00000216080.5	-	6	992	c.824G>T	c.(823-825)cGc>cTc	p.R275L	LMF2_ENST00000474879.2_Missense_Mutation_p.R300L|LMF2_ENST00000380796.3_Missense_Mutation_p.R300L			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	300						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGTCTTCTTGCGGCTGCCGTG	0.632000													7	0					0.000422831	0.000438372	0.028581	1	0
MRE11A	4361	broad.mit.edu	37	11	94180429	94180429	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:94180429C>T	ENST00000323929.3	-	15	1961	c.1739G>A	c.(1738-1740)aGa>aAa	p.R580K	MRE11A_ENST00000323977.3_Missense_Mutation_p.R580K|MRE11A_ENST00000393241.4_Missense_Mutation_p.R580K|MRE11A_ENST00000407439.3_Missense_Mutation_p.R583K	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	580					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				ATTCTGCCCTCTTCCACCTCT	0.478000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				237	430					0	0	0.048971	0	0
KCNN3	3782	broad.mit.edu	37	1	154680544	154680544	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:154680544C>A	ENST00000271915.3	-	8	2419	c.2104G>T	c.(2104-2106)Gtg>Ttg	p.V702L	KCNN3_ENST00000515643.1_5'UTR|KCNN3_ENST00000358505.2_Missense_Mutation_p.V389L|KCNN3_ENST00000361147.4_Missense_Mutation_p.V397L	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	707						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GTGGTGCCCACTGCCACGCTG	0.612000													55	67					1.38909e-20	1.82961e-20	0.048971	1	0
KPNA5	3841	broad.mit.edu	37	6	117043355	117043355	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:117043355G>T	ENST00000368564.1	+	9	971	c.823G>T	c.(823-825)Gtg>Ttg	p.V275L	KPNA5_ENST00000356348.1_Missense_Mutation_p.V275L			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	272					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GTTAGCAGACGTGTGTTGGGC	0.408000													66	99					4.66136e-34	6.95098e-34	0.048971	1	0
ZNF133	7692	broad.mit.edu	37	20	18297071	18297071	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr20:18297071G>T	ENST00000377671.3	+	7	2132	c.1573G>T	c.(1573-1575)Gag>Tag	p.E525*	ZNF133_ENST00000401790.1_Nonsense_Mutation_p.E526*|ZNF133_ENST00000402618.2_Nonsense_Mutation_p.E463*|ZNF133_ENST00000396026.3_Nonsense_Mutation_p.E529*|ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000538547.1_Nonsense_Mutation_p.E431*|ZNF133_ENST00000535822.1_Nonsense_Mutation_p.E431*|ZNF133_ENST00000316358.4_Nonsense_Mutation_p.E526*	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	526						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						TGTGTGCCGAGAGTGCGGGCG	0.622000													44	78					3.21987e-24	4.41266e-24	0.048971	1	0
MRPL9	65005	broad.mit.edu	37	1	151732565	151732565	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr1:151732565delT	ENST00000368830.3	-	7	849	c.765delA	c.(763-765)cafs	p.Q255fs	MRPL9_ENST00000368829.3_Frame_Shift_Del_p.Q221fs|MRPL9_ENST00000467306.1_5'UTR	NM_031420.2	NP_113608.1	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9	255					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCTTGGCAGCTTGCTGGGCTA	0.512													58	95	---	---	---	---					
CYP27A1	1593	broad.mit.edu	37	2	219677646	219677646	+	Splice_Site	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr2:219677646delG	ENST00000258415.4	+	5	1271		c.e5-1			NM_000784.3	NP_000775.1	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A, polypeptide 1						bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(3)|urinary_tract(1)	26		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGCTTTCACAGGGAAGAAGCT	0.517													29	35	---	---	---	---					
GPR98	84059	broad.mit.edu	37	5	90106258	90106258	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr5:90106258delG	ENST00000405460.2	+	74	15277	c.15181delG	c.(15181-15183)ggfs	p.G5061fs	GPR98_ENST00000425867.2_Frame_Shift_Del_p.G722fs	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5061	Calx-beta 33.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTCAGAATGGGGAACTGTT	0.358													22	33	---	---	---	---					
TAP2	6891	broad.mit.edu	37	6	32805380	32805380	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr6:32805380delC	ENST00000374897.2	-	3	673	c.542delG	c.(541-543)gafs	p.G182fs	TAP2_ENST00000374899.4_Frame_Shift_Del_p.G182fs|TAP2_ENST00000452392.2_Frame_Shift_Del_p.G182fs	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	182	ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										AAAATCACCTCCCAGGATGTC	0.507													46	94	---	---	---	---					
HGF	3082	broad.mit.edu	37	7	81392156	81392157	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:81392156_81392157insA	ENST00000222390.5	-	2	346_347	c.120_121insT	c.(118-123)caaattfs	p.QI40fs	HGF_ENST00000453018.1_5'UTR|HGF_ENST00000457544.2_Frame_Shift_Ins_p.QI40fs|HGF_ENST00000354224.6_Frame_Shift_Ins_p.QI40fs|HGF_ENST00000423064.2_Frame_Shift_Ins_p.QI40fs|HGF_ENST00000444829.2_Frame_Shift_Ins_p.QI40fs|HGF_ENST00000453411.1_Frame_Shift_Ins_p.QI40fs	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	40	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTTTTGAATTCATGAATTGTAT	0.277													24	59	---	---	---	---					
SAMD9L	219285	broad.mit.edu	37	7	92762932	92762932	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:92762932delC	ENST00000318238.4	-	5	3569	c.2353delG	c.(2353-2355)tcfs	p.V785fs	SAMD9L_ENST00000437805.1_Frame_Shift_Del_p.V785fs|SAMD9L_ENST00000411955.1_Frame_Shift_Del_p.V785fs	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	785										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTATAGGTGACCAGATTGATC	0.378													268	557	---	---	---	---					
LOC101928451	101928451	broad.mit.edu	37	7	128210235	128210236	+	RNA	DEL	TT	TT	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr7:128210235_128210236delTT	ENST00000605862.1	+	0	189																											gttttagttcttTTTTTTTTTT	0.441													2	4	---	---	---	---					
MATN2	4147	broad.mit.edu	37	8	98943445	98943446	+	Frame_Shift_Ins	INS	-	-	T	rs2290470	by1000genomes	TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr8:98943445_98943446insT	ENST00000254898.5	+	3	638_639	c.407_408insT	c.(406-408)aggfs	p.R136fs	MATN2_ENST00000524308.1_Frame_Shift_Ins_p.R136fs|MATN2_ENST00000522025.2_Intron|MATN2_ENST00000521689.1_Frame_Shift_Ins_p.R136fs|MATN2_ENST00000520016.1_Frame_Shift_Ins_p.R136fs	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	136	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GGCACCATGACTGGGCTGGCCA	0.574													32	41	---	---	---	---					
CCIN	881	broad.mit.edu	37	9	36171041	36171042	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:36171041_36171042delTG	ENST00000335119.2	+	1	1653_1654	c.1542_1543delTG	c.(1540-1545)gatgfs	p.DV514fs		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	514					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			GCCCCTTGGATGTGTCCCATGC	0.540													95	114	---	---	---	---					
RP11-213G2.2	0	broad.mit.edu	37	9	88401139	88401140	+	RNA	INS	-	-	A			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr9:88401139_88401140insA	ENST00000443630.1	-	0	317																											GACAGTTCAGCAAGCAGCTTAA	0.431													39	66	---	---	---	---					
OR56B1	387748	broad.mit.edu	37	11	5757908	5757908	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:5757908delC	ENST00000317121.3	+	1	228	c.162delC	c.(160-162)atfs	p.I54fs	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ACACCCTCATCCTCATCATCA	0.512													91	27	---	---	---	---					
OR10A6	390093	broad.mit.edu	37	11	7949605	7949605	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:7949605delC	ENST00000309838.2	-	1	604	c.605delG	c.(604-606)gcfs	p.G202fs		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAAAAAGGTGCCTGTGAATGC	0.393													105	21	---	---	---	---					
PDE3B	5140	broad.mit.edu	37	11	14865565	14865565	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr11:14865565delC	ENST00000282096.4	+	12	2866	c.2513delC	c.(2512-2514)gcfs	p.A838fs	PDE3B_ENST00000455098.2_Frame_Shift_Del_p.A787fs	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	838	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GCTACAAATGCCCCTCAGGTA	0.378													134	50	---	---	---	---					
ANO2	57101	broad.mit.edu	37	12	5687633	5687633	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:5687633delG	ENST00000327087.8	-	22	2356	c.2285delC	c.(2284-2286)ctfs	p.P762fs	ANO2_ENST00000546188.1_Frame_Shift_Del_p.P763fs|ANO2_ENST00000356134.5_Frame_Shift_Del_p.P763fs			Q9NQ90	ANO2_HUMAN	anoctamin 2	767						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity	p.P763L(1)		central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GGCAAACACAGGTGCCAGGGG	0.522													39	8	---	---	---	---					
ZNF664-FAM101A	100533183	broad.mit.edu	37	12	124719518	124719520	+	RNA	DEL	ATA	ATA	-	rs112028864		TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr12:124719518_124719520delATA	ENST00000540762.1	+	0	444																											cattaccaccataatcatcatca	0.488													4	4	---	---	---	---					
CES5A	221223	broad.mit.edu	37	16	55907815	55907815	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr16:55907815delG	ENST00000521992.1	-	3	440	c.295delC	c.(295-297)tgfs	p.L99fs	CES5A_ENST00000290567.9_Frame_Shift_Del_p.L70fs|CES5A_ENST00000319165.9_Frame_Shift_Del_p.L70fs|CES5A_ENST00000518005.1_5'UTR|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000520435.1_Frame_Shift_Del_p.L70fs	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	70						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GTAAATCGCAGGGATCCCAGC	0.597													24	16	---	---	---	---					
TSHZ1	10194	broad.mit.edu	37	18	72999246	72999247	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr18:72999246_72999247insC	ENST00000322038.5	+	2	2333_2334	c.1749_1750insC	c.(1747-1752)acccccfs	p.TP583fs	TSHZ1_ENST00000580243.1_Frame_Shift_Ins_p.TP628fs	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	628						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GGAGCCTCACGCCCCCACCGCA	0.639													31	64	---	---	---	---					
GOLGA2P9	440518	broad.mit.edu	37	19	22780047	22780047	+	RNA	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:22780047delG	ENST00000600260.1	+	0	163					NR_033899.1																						tgtgattgtagggacttctca	0.383													44	62	---	---	---	---					
LMTK3	114783	broad.mit.edu	37	19	48994680	48994680	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:48994680delG	ENST00000600059.1	-	13	4436	c.4209delC	c.(4207-4209)ccfs	p.P1403fs	LMTK3_ENST00000270238.3_Frame_Shift_Del_p.P1432fs					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TGTCGTTGCTGGGAAACCCAT	0.741													4	5	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57272345	57272345	+	RNA	DEL	G	G	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr19:57272345delG	ENST00000594400.1	+	0	266				AC006115.3_ENST00000597822.1_RNA																							TGGCCACAGTGGTTCAGATCC	0.592													4	2	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11049811	11049811	+	RNA	DEL	C	C	-			TCGA-17-Z049-01A-01W-0746-08	TCGA-17-Z049-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac31bcc6-6ccc-43b7-96f2-3ab47050be76	19f580ae-ea08-4615-b7ed-f6fdcbb35e4e	g.chr21:11049811delC	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTAAATGTAACCACATTAAAT	0.294													3	4	---	---	---	---					
