Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RGS12	6002	broad.mit.edu	37	4	3318367	3318367	+	Missense_Mutation	SNP	G	G	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr4:3318367G>T	ENST00000336727.3	+	2	1374	c.470G>T	c.(469-471)tGt>tTt	p.C157F	RGS12_ENST00000382788.3_Missense_Mutation_p.C157F|RGS12_ENST00000344733.5_Missense_Mutation_p.C157F|RGS12_ENST00000543385.1_Missense_Mutation_p.C157F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	157						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCGAGCCTTTGTGCGAGCAAT	0.413000													7	69					0.248553	0.248553	1	1	0
DENND3	22898	broad.mit.edu	37	8	142202483	142202483	+	Silent	SNP	T	T	C			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr8:142202483T>C	ENST00000519811.1	+	21	3503	c.3433T>C	c.(3433-3435)Ttg>Ctg	p.L1145L	DENND3_ENST00000424248.1_Silent_p.L1013L|DENND3_ENST00000523308.1_Silent_p.L115L|DENND3_ENST00000262585.2_Silent_p.L1065L			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1065										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCATCAAGAATTGAAGATTGA	0.532000													4	66					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324040	9324040	+	Silent	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr1:9324040G>A	ENST00000377403.2	+	5	1790	c.1488G>A	c.(1486-1488)aaG>aaA	p.K496K	H6PD_ENST00000602477.1_Silent_p.K507K	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	496	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	TGGCCCATAAGGCCCCACGCC	0.577000													21	271					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	24					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101096474	101096474	+	Missense_Mutation	SNP	C	C	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chrX:101096474C>A	ENST00000537026.1	-	6	656	c.297G>T	c.(295-297)aaG>aaT	p.K99N	NXF5_ENST00000361708.2_Missense_Mutation_p.K99N|NXF5_ENST00000473265.2_Missense_Mutation_p.K99N	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	99					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						TTTGGCCTGGCTTCAACTTAT	0.483000													7	58					0.00448238	0.00480255	1	1	0
ATF4	468	broad.mit.edu	37	22	39917589	39917589	+	Missense_Mutation	SNP	C	C	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr22:39917589C>T	ENST00000337304.2	+	1	1021	c.139C>T	c.(139-141)Cat>Tat	p.H47Y	ATF4_ENST00000396680.1_Missense_Mutation_p.H47Y|ATF4_ENST00000404241.2_Missense_Mutation_p.H47Y	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	47					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					CTTCAAACCTCATGGGTTCTC	0.582000													12	109					0	0	1	0	0
CCDC124	115098	broad.mit.edu	37	19	18054500	18054500	+	Silent	SNP	C	C	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr19:18054500C>T	ENST00000597436.1	+	5	755	c.648C>T	c.(646-648)gcC>gcT	p.A216A	CCDC124_ENST00000445755.2_Silent_p.A216A	NM_138442.3	NP_612451.1	Q96CT7	CC124_HUMAN	coiled-coil domain containing 124	216							DNA binding			central_nervous_system(1)|kidney(2)	3						ACCAGCGGGCCGTGCCCTTCA	0.612000													5	28					0	0	1	0	0
FAR2	55711	broad.mit.edu	37	12	29469919	29469919	+	Silent	SNP	T	T	C			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr12:29469919T>C	ENST00000182377.4	+	9	1369	c.1101T>C	c.(1099-1101)taT>taC	p.Y367Y	FAR2_ENST00000547116.1_Silent_p.Y270Y|RP11-996F15.2_ENST00000553105.1_RNA|FAR2_ENST00000536681.2_Silent_p.Y367Y	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	367					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						ATGACTGCTATCTGCGGCTCA	0.507000													34	218					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000358919.2_Missense_Mutation_p.S304T|DLC1_ENST00000520226.1_Missense_Mutation_p.S230T|DLC1_ENST00000512044.2_Missense_Mutation_p.S338T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627000													4	72					0	0	1	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13927900	13927900	+	RNA	SNP	T	T	C			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr17:13927900T>C	ENST00000602743.1	-	0	224																											GAGCCTTTTCTGACGATGCCG	0.572000													6	66					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417108	62417108	+	Silent	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr11:62417108G>A	ENST00000330574.2	-	2	496	c.444C>T	c.(442-444)tcC>tcT	p.S148S		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	148					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						TGAGGTCAATGGACCATGCAC	0.567000													8	107					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241326	126241326	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr4:126241326G>T	ENST00000394329.3	+	1	3773	c.3760G>T	c.(3760-3762)Gaa>Taa	p.E1254*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1254	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAAAGGAAATGAAGAAAGACA	0.373000													4	38					0.150653	0.155848	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49443497	49443497	+	Missense_Mutation	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr12:49443497G>A	ENST00000301067.7	-	11	3873	c.3874C>T	c.(3874-3876)Cgc>Tgc	p.R1292C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGGAGCTGCGCCGCCGCCCC	0.582000													4	59					0	0	1	0	0
SLC50A1	55974	broad.mit.edu	37	1	155109396	155109396	+	Missense_Mutation	SNP	T	T	G			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr1:155109396T>G	ENST00000368404.4	+	3	313	c.251T>G	c.(250-252)aTc>aGc	p.I84S	SLC50A1_ENST00000303343.8_Missense_Mutation_p.I84S|SLC50A1_ENST00000368405.3_Intron|SLC50A1_ENST00000368401.5_Intron|SLC50A1_ENST00000484157.1_Intron	NM_018845.3	NP_061333.2	Q9BRV3	SWET1_HUMAN	solute carrier family 50 (sugar efflux transporter), member 1	84	MtN3/slv 1.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						ACCCTGTATATCTTGGCATAT	0.572000													8	64					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951088	235951088	+	Missense_Mutation	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr2:235951088G>A	ENST00000409212.1	+	4	2182	c.1675G>A	c.(1675-1677)Gtg>Atg	p.V559M	SH3BP4_ENST00000392011.2_Missense_Mutation_p.V559M|SH3BP4_ENST00000344528.4_Missense_Mutation_p.V559M			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	559					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGCCAAAGTGGTGCGAGGATT	0.552000													9	121					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57797944	57797944	+	Missense_Mutation	SNP	C	C	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr4:57797944C>T	ENST00000309042.7	+	4	3234	c.2920C>T	c.(2920-2922)Ctt>Ttt	p.L974F		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	974					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					TTCACCAATGCTTCCCCCTTC	0.423000													4	49					0	0	1	0	0
KRTAP5-6	440023	broad.mit.edu	37	11	1718512	1718512	+	Missense_Mutation	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr11:1718512G>A	ENST00000382160.1	+	1	88	c.37G>A	c.(37-39)Ggc>Agc	p.G13S		NM_001012416.1	NP_001012416.1	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	13						keratin filament				endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTGTGGCTCCGGCTGTGGGGG	0.647000													22	234					0	0	1	0	0
LAMTOR5	10542	broad.mit.edu	37	1	110946580	110946580	+	Missense_Mutation	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr1:110946580G>A	ENST00000474861.2	-	3	779	c.173C>T	c.(172-174)cCc>cTc	p.P58L	LAMTOR5_ENST00000602318.1_Missense_Mutation_p.P59L|LAMTOR5-AS1_ENST00000590413.1_RNA|LAMTOR5_ENST00000483260.1_Missense_Mutation_p.P58L|LAMTOR5_ENST00000602858.1_Missense_Mutation_p.P47L|LAMTOR5_ENST00000256644.4_Missense_Mutation_p.P141L					late endosomal/lysosomal adaptor, MAPK and MTOR activator 5																		AATATCAGTGGGGTCAGAGGT	0.448000													5	102					0	0	1	0	0
DNAJB1	3337	broad.mit.edu	37	19	14627610	14627610	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr19:14627610C>A	ENST00000254322.2	-	2	530	c.460G>T	c.(460-462)Gag>Tag	p.E154*	DNAJB1_ENST00000396969.4_Nonsense_Mutation_p.E54*	NM_006145.1	NP_006136.1	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	154					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding			NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|urinary_tract(1)	16				GBM - Glioblastoma multiforme(1328;0.0476)		CGGGCGGGCTCTTGGGCAGAG	0.567000													11	136					3.86212e-05	4.29124e-05	1	1	0
TMX3	54495	broad.mit.edu	37	18	66348256	66348256	+	Missense_Mutation	SNP	C	C	T	rs149874821	byFrequency	TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr18:66348256C>T	ENST00000299608.2	-	14	1313	c.997G>A	c.(997-999)Gtc>Atc	p.V333I		NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	333					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						ATAAACTGGACCATGTCTTCA	0.363000													4	37					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78163584	78163584	+	Silent	SNP	C	C	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr17:78163584C>T	ENST00000573882.1	+	8	1412	c.876C>T	c.(874-876)gaC>gaT	p.D292D	CARD14_ENST00000570421.1_Silent_p.D292D|CARD14_ENST00000344227.2_Silent_p.D292D|CARD14_ENST00000392434.2_Silent_p.D55D|CARD14_ENST00000573754.1_3'UTR			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	292					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGAGCCTGGACGAGGCGCGGG	0.692000													4	35					0	0	1	0	0
POLR2J4	84820	broad.mit.edu	37	7	44054352	44054352	+	RNA	SNP	T	T	C	rs56000326	by1000genomes	TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr7:44054352T>C	ENST00000427076.1	-	0	209					NR_003655.2																						AGCCAGCAAATAGCACTTGCG	0.577000													9	205					0	0	1	0	0
VAPA	9218	broad.mit.edu	37	18	9950496	9950496	+	Silent	SNP	A	A	G			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr18:9950496A>G	ENST00000400000.2	+	5	777	c.522A>G	c.(520-522)aaA>aaG	p.K174K	VAPA_ENST00000584796.1_3'UTR|VAPA_ENST00000340541.4_Silent_p.K219K	NM_003574.5|NM_194434.2	NP_003565.4|NP_919415.2	Q9P0L0	VAPA_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	174					cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						AAACAAGGAAACTAATGGAAG	0.383000													3	33					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89386860	89386860	+	Silent	SNP	C	C	T			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr15:89386860C>T	ENST00000439576.2	+	6	1406	c.1032C>T	c.(1030-1032)taC>taT	p.Y344Y	ACAN_ENST00000558207.1_Silent_p.Y344Y|ACAN_ENST00000352105.7_Silent_p.Y344Y|ACAN_ENST00000561243.1_Silent_p.Y344Y|ACAN_ENST00000559004.1_Silent_p.Y344Y	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	344					cell adhesion		hyaluronic acid binding|sugar binding	p.Y344Y(1)		NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CATCCCGCTACGACGCCATCT	0.627000													5	100					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39596496	39596496	+	Missense_Mutation	SNP	G	G	A			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr13:39596496G>A	ENST00000352251.3	-	9	1530	c.697C>T	c.(697-699)Cca>Tca	p.P233S	PROSER1_ENST00000484434.2_Intron|PROSER1_ENST00000350125.3_Missense_Mutation_p.P211S	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	233	Pro-rich.																TATGGAGGTGGAGGTGGAGCT	0.368000													4	51					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29456443	29456443	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-A44F-01A-11D-A24D-08	TCGA-38-A44F-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fca672fe-fe50-4a91-be75-6c1eff51b090	16729fc7-4c8b-47f9-9628-7adef0737ac1	g.chr2:29456443delG	ENST00000389048.3	-	14	3381	c.2475delC	c.(2473-2475)acfs	p.T825fs	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	825	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TAAATACGTAGGTGGCTCCAC	0.517			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				11	132	---	---	---	---					
