Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP26B1	56603	broad.mit.edu	37	2	72362467	72362467	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:72362467C>A	ENST00000001146.2	-	3	714	c.511G>T	c.(511-513)Gcc>Tcc	p.A171S	CYP26B1_ENST00000412253.1_5'UTR|CYP26B1_ENST00000546307.1_Missense_Mutation_p.A96S	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	171					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						CTGCTCCAGGCGCGCAGTGTG	0.617000													5	103					0.014758	0.0158932	1	1	0
CPSF2	53981	broad.mit.edu	37	14	92627534	92627534	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr14:92627534C>G	ENST00000298875.4	+	15	2485	c.2200C>G	c.(2200-2202)Caa>Gaa	p.Q734E		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	734					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		GGAGGGGATTCAAGCTGAATT	0.428000													4	68					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89656982	89656982	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:89656982G>C	ENST00000355754.6	-	6	975	c.878C>G	c.(877-879)aCc>aGc	p.T293S		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	293						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CAGGGTCTTGGTCTTTGCATG	0.413000													4	52					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43818105	43818105	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:43818105G>A	ENST00000377564.3	+	7	1385	c.992G>A	c.(991-993)gGg>gAg	p.G331E	CNTNAP3B_ENST00000276974.6_Missense_Mutation_p.G331E	NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	331	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCTTTCATGGGTGTTTAGAA	0.388000													3	32					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170277	36170277	+	Missense_Mutation	SNP	C	C	T	rs140883913	byFrequency	TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:36170277C>T	ENST00000335119.2	+	1	889	c.778C>T	c.(778-780)Cgc>Tgc	p.R260C		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	260					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			CCTGATGGACCGCAAGCAGGA	0.587000													9	45					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52673893	52673893	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr13:52673893G>A	ENST00000355568.4	-	12	1151	c.1012C>T	c.(1012-1014)Cag>Tag	p.Q338*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	338							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTGGCCTTCTGGGCTCCAGCT	0.408000													13	32					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589746	140589746	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr5:140589746G>A	ENST00000239450.2	+	1	1456	c.1267G>A	c.(1267-1269)Gtc>Atc	p.V423I	PCDHB12_ENST00000541609.1_Missense_Mutation_p.V86I	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		423	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCATCACCGTCACCGACTT	0.517000													6	103					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66453366	66453366	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:66453366G>T	ENST00000533211.1	-	38	7480	c.7149C>A	c.(7147-7149)ttC>ttA	p.F2383L	SPTBN2_ENST00000529997.1_3'UTR|SPTBN2_ENST00000309996.2_Missense_Mutation_p.F2383L			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2383					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						TAAAGAAGCTGAAGCGTTTTT	0.612000													7	84					1.06961e-07	1.30214e-07	1	1	0
ZNF250	58500	broad.mit.edu	37	8	146108179	146108179	+	Missense_Mutation	SNP	G	G	A	rs143336224		TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr8:146108179G>A	ENST00000292579.7	-	6	520	c.404C>T	c.(403-405)cCg>cTg	p.P135L	ZNF250_ENST00000543949.1_Intron|ZNF250_ENST00000342660.6_Intron|ZNF250_ENST00000417550.2_Missense_Mutation_p.P130L	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TAATGGCTTCGGACTCAAGTC	0.383000													7	94					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134645358	134645358	+	Silent	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:134645358G>A	ENST00000361388.2	+	13	2053	c.1587G>A	c.(1585-1587)aaG>aaA	p.K529K	CALD1_ENST00000466704.1_3'UTR|CALD1_ENST00000361675.2_Silent_p.K758K|CALD1_ENST00000424922.1_Silent_p.K497K|CALD1_ENST00000361901.2_Silent_p.K503K|CALD1_ENST00000543443.1_Silent_p.K508K|CALD1_ENST00000417172.1_Silent_p.K503K|CALD1_ENST00000393118.2_Silent_p.K523K|CALD1_ENST00000495522.1_Silent_p.K522K|CALD1_ENST00000422748.1_Silent_p.K528K	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	758					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						ATGGAAACAAGTCACCTGCTC	0.438000													5	19					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578271	7578271	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:7578271T>A	ENST00000420246.2	-	6	710	c.578A>T	c.(577-579)cAt>cTt	p.H193L	TP53_ENST00000269305.4_Missense_Mutation_p.H193L|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.H193L|TP53_ENST00000445888.2_Missense_Mutation_p.H193L|TP53_ENST00000413465.2_Missense_Mutation_p.H193L|TP53_ENST00000455263.2_Missense_Mutation_p.H193L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(80)|p.H193L(42)|p.H193P(18)|p.0?(8)|p.?(6)|p.H61R(4)|p.H100R(4)|p.H100L(4)|p.H61L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.H193fs*16(3)|p.P191fs*53(2)|p.H61P(2)|p.H100P(2)|p.A189fs*53(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P98_E105>Q(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	37					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2463960	2463960	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr20:2463960G>T	ENST00000278772.4	-	6	2134	c.1647C>A	c.(1645-1647)taC>taA	p.Y549*	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	549					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						CACTGCACACGTAAGGCTTCT	0.502000													6	55					2.0095e-06	2.3943e-06	1	1	0
PIKFYVE	200576	broad.mit.edu	37	2	209138435	209138435	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:209138435C>T	ENST00000264380.4	+	3	458	c.300C>T	c.(298-300)ctC>ctT	p.L100L	PIKFYVE_ENST00000392202.3_Silent_p.L100L|PIKFYVE_ENST00000407449.1_Silent_p.L100L|PIKFYVE_ENST00000308862.6_Silent_p.L100L	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	100					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ATGAGGAACTCCAGCGGCGCT	0.443000													5	60					0	0	1	0	0
MYC	4609	broad.mit.edu	37	8	128750809	128750809	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr8:128750809A>G	ENST00000377970.2	+	2	856	c.346A>G	c.(346-348)Atg>Gtg	p.M116V	MYC_ENST00000259523.6_Missense_Mutation_p.M101V|MYC_ENST00000524013.1_Missense_Mutation_p.M115V	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	101					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		CCAGCTGGAGATGGTGACCGA	0.602000		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	32					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11579486	11579486	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:11579486G>T	ENST00000294484.6	+	8	2102	c.1964G>T	c.(1963-1965)gGa>gTa	p.G655V	PTCHD2_ENST00000389575.3_Missense_Mutation_p.G655V	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	655					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GAGCAGGTTGGAGGCAGCCCT	0.637000													10	162					3.86212e-05	4.36927e-05	1	1	0
AGMAT	79814	broad.mit.edu	37	1	15905400	15905400	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:15905400C>T	ENST00000375826.3	-	4	816	c.674G>A	c.(673-675)cGg>cAg	p.R225Q	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	225					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGAGCCCCGGATGCCAAT	0.602000													4	30					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95718600	95718600	+	RNA	SNP	T	T	C	rs11815169	by1000genomes	TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr10:95718600T>C	ENST00000480546.1	-	0	2697					NR_002319.2																						TCCTTCTTGCTGTCCTTGGTG	0.547000													3	35					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65342649	65342649	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:65342649C>T	ENST00000402939.2	-	23	3792	c.3793G>A	c.(3793-3795)Gat>Aat	p.D1265N	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1294					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CCTTTCGGATCCCTTGCGTGT	0.592000													8	117					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113848603	113848603	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:113848603A>T	ENST00000504030.2	+	2	623	c.178A>T	c.(178-180)Acc>Tcc	p.T60S	HTR3A_ENST00000506841.2_Missense_Mutation_p.T60S|HTR3A_ENST00000299961.5_Missense_Mutation_p.T45S|HTR3A_ENST00000535865.1_5'UTR|HTR3A_ENST00000375498.2_Missense_Mutation_p.T66S|HTR3A_ENST00000355556.2_Missense_Mutation_p.T66S			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	60					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GAAGCCAACCACCGTATCCAT	0.592000													5	72					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283199	152283199	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:152283199C>T	ENST00000368799.1	-	3	4198	c.4163G>A	c.(4162-4164)cGa>cAa	p.R1388Q	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1388	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGGACCCTCGGTGTCCACT	0.562000									Ichthyosis				16	480					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92627506	92627506	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr14:92627506C>T	ENST00000298875.4	+	15	2457	c.2172C>T	c.(2170-2172)ttC>ttT	p.F724F		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	724					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TGTCAGACTTCAAGCAAGTTC	0.413000													4	61					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21206819	21206819	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:21206819G>A	ENST00000357374.2	-	1	323	c.278C>T	c.(277-279)aCa>aTa	p.T93I		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	93					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		TGAGTCCTCTGTGCTGAAGAG	0.493000													14	69					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88478006	88478006	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr14:88478006A>G	ENST00000267549.3	+	2	1373	c.815A>G	c.(814-816)tAt>tGt	p.Y272C	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	272					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TACACAATGTATAGAATCACG	0.373000													4	31					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33684076	33684076	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr13:33684076G>A	ENST00000336934.5	-	12	3097	c.2981C>T	c.(2980-2982)aCa>aTa	p.T994I	STARD13_ENST00000255486.4_Missense_Mutation_p.T986I|STARD13_ENST00000399365.3_Missense_Mutation_p.T876I	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	994	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GTAGATCTCTGTTTGCCTGTC	0.537000											OREG0022359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	68					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4554407	4554407	+	Missense_Mutation	SNP	A	A	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr19:4554407A>C	ENST00000586582.1	-	9	1074	c.764T>G	c.(763-765)cTg>cGg	p.L255R	SEMA6B_ENST00000301293.3_Missense_Mutation_p.L255R|SEMA6B_ENST00000586965.1_Missense_Mutation_p.L255R	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	255	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCTTCTCCAGGTAGTTAAA	0.567000													4	21					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958498	143958498	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr8:143958498T>G	ENST00000292427.4	-	3	568	c.536A>C	c.(535-537)aAc>aCc	p.N179T	CYP11B1_ENST00000377675.3_Missense_Mutation_p.N250T|CYP11B1_ENST00000517471.1_Missense_Mutation_p.N179T	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	179					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CCCCCGGGCGTTCTGCAGCAC	0.622000									Familial Hyperaldosteronism type I				3	28					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38855744	38855744	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr19:38855744G>T	ENST00000409235.3	+	22	2715	c.2600G>T	c.(2599-2601)gGg>gTg	p.G867V	CATSPERG_ENST00000410018.1_Missense_Mutation_p.G827V|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	867					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ACACACCTGGGGCCCCATATG	0.597000													7	59					0.000157383	0.000176269	1	1	0
TRIM58	25893	broad.mit.edu	37	1	248039760	248039760	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:248039760C>T	ENST00000366481.3	+	6	1478	c.1430C>T	c.(1429-1431)cCt>cTt	p.P477L	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	477						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CATTTAGATCCTGCTTCTGAT	0.448000													4	48					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30804817	30804817	+	Silent	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr20:30804817G>A	ENST00000375730.3	+	5	598	c.549G>A	c.(547-549)gaG>gaA	p.E183E	POFUT1_ENST00000375749.3_Intron|POFUT1_ENST00000486717.1_Intron|POFUT1_ENST00000539210.1_Intron	NM_172236.1	NP_758436.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	0					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity	p.E183E(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTAGGCGTGAGAATCACTCCT	0.458000													3	38					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234345041	234345041	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:234345041G>T	ENST00000264057.2	+	7	785	c.773G>T	c.(772-774)aGt>aTt	p.S258I	DGKD_ENST00000409813.3_Missense_Mutation_p.S214I	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	258					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ACCTGTGGCAGTGTGCTGCGC	0.637000													4	69					0.150653	0.153393	1	1	0
CDC5L	988	broad.mit.edu	37	6	44371653	44371653	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr6:44371653T>G	ENST00000371477.3	+	6	946	c.647T>G	c.(646-648)tTt>tGt	p.F216C		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	216					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAAATCCCATTTGAAAAAAAG	0.403000													6	37					0	0	1	0	0
EDARADD	128178	broad.mit.edu	37	1	236645797	236645797	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:236645797G>A	ENST00000359362.5	+	6	680	c.466G>A	c.(466-468)Gag>Aag	p.E156K	EDARADD_ENST00000334232.4_Missense_Mutation_p.E166K	NM_080738.3	NP_542776.1	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain	166	Death.				cell differentiation|signal transduction	cytoplasm				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|stomach(1)	12	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CCCCACCTTGGAGTTCTTGCT	0.572000													8	87					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080810	126080810	+	Silent	SNP	C	C	T	rs146693390		TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr6:126080810C>T	ENST00000368364.3	+	5	1073	c.876C>T	c.(874-876)aaC>aaT	p.N292N	HEY2_ENST00000368365.1_Silent_p.N246N	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	292	Ala-rich.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		TTCCCCCAAACGCAGCAGCAG	0.647000													15	257					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14063097	14063097	+	RNA	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:14063097G>A	ENST00000310358.7	+	0	913							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CTCAGTTTATGAGCAATTGCC	0.478000													5	120					0	0	1	0	0
CDC14A	8556	broad.mit.edu	37	1	100933521	100933521	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:100933521G>T	ENST00000336454.3	+	10	1203	c.848G>T	c.(847-849)gGa>gTa	p.G283V	CDC14A_ENST00000544534.1_Missense_Mutation_p.G283V|RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000361544.6_Missense_Mutation_p.G283V|CDC14A_ENST00000370124.3_Missense_Mutation_p.G283V|CDC14A_ENST00000370125.2_3'UTR|CDC14A_ENST00000542213.1_Missense_Mutation_p.G225V	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	283	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		GCTGGTCTTGGAAGAACAGGG	0.383000													4	61					0.150653	0.153393	1	1	0
FLG	2312	broad.mit.edu	37	1	152282974	152282974	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:152282974C>G	ENST00000368799.1	-	3	4423	c.4388G>C	c.(4387-4389)gGa>gCa	p.G1463A	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1463	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTCTTCCTCCAGTGCTGGG	0.572000									Ichthyosis				11	323					0	0	1	0	0
C17orf66	256957	broad.mit.edu	37	17	34185257	34185257	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:34185257C>A	ENST00000311880.2	-	11	1247	c.1099G>T	c.(1099-1101)Gag>Tag	p.E367*	C17orf66_ENST00000592980.1_Nonsense_Mutation_p.E327*	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	367							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GTGAGTTCCTCTAGCCCCTGT	0.537000													10	145					3.86212e-05	4.36927e-05	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151860499	151860499	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:151860499T>C	ENST00000355193.2	-	43	10381	c.10163A>G	c.(10162-10164)aAc>aGc	p.N3388S	KMT2C_ENST00000262189.6_Missense_Mutation_p.N3388S					lysine (K)-specific methyltransferase 2C																		AAAGGGATTGTTGTCATCAAA	0.453000													8	114					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175664886	175664886	+	Silent	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:175664886C>A	ENST00000409900.3	-	13	1651	c.1338G>T	c.(1336-1338)ctG>ctT	p.L446L	CHN1_ENST00000409597.1_Silent_p.L262L|CHN1_ENST00000488080.1_5'UTR|CHN1_ENST00000295497.7_Silent_p.L321L|CHN1_ENST00000409156.3_Silent_p.L420L	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	446	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			GCTCCACCACCAGTCTCTGAT	0.373000			T	TAF15	extraskeletal myxoid chondrosarcoma								5	30					1.23904e-05	1.43064e-05	1	1	0
P4HTM	54681	broad.mit.edu	37	3	49038897	49038897	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:49038897G>C	ENST00000343546.4	+	3	831	c.463G>C	c.(463-465)Gag>Cag	p.E155Q	P4HTM_ENST00000383729.4_Missense_Mutation_p.E155Q|P4HTM_ENST00000468374.1_3'UTR	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	155						endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	GACTGATGAAGAGTGTCGGCT	0.567000													5	37					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596970	142596970	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:142596970C>G	ENST00000370503.2	-	2	183	c.100G>C	c.(100-102)Gtc>Ctc	p.V34L	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	34										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCTAAGACTCTGTTTGGT	0.383000													7	39					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101763579	101763579	+	Splice_Site	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr13:101763579T>C	ENST00000251127.6	-	19	2274		c.e19-2			NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective							integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTGCAAGCTCTAGGAAAAAAA	0.458000													7	60					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228104	39228104	+	Silent	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:39228104G>T	ENST00000340369.3	-	2	3061	c.2833C>A	c.(2833-2835)Cgg>Agg	p.R945R	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Silent_p.R945R	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	945							actin binding	p.R945W(1)		breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGCTCCCACCGCAGACTGTGC	0.642000													7	61					0.0293803	0.0310434	1	1	0
NAT10	55226	broad.mit.edu	37	11	34156118	34156118	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:34156118C>A	ENST00000257829.3	+	18	2102	c.1896C>A	c.(1894-1896)caC>caA	p.H632Q	NAT10_ENST00000531159.2_Missense_Mutation_p.H560Q|NAT10_ENST00000527971.1_Intron	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	632	N-acetyltransferase.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TTGCTGTTCACCCAGATTATC	0.527000													7	69					0.00198382	0.00219988	1	1	0
COL9A2	1298	broad.mit.edu	37	1	40773385	40773385	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:40773385G>A	ENST00000372748.3	-	18	1040	c.944C>T	c.(943-945)cCt>cTt	p.P315L		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	315	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CTTCATGCCAGGCGTGCCTGG	0.612000													5	25					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65156439	65156439	+	Silent	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:65156439G>C	ENST00000358691.5	-	17	2281	c.2115C>G	c.(2113-2115)ctC>ctG	p.L705L	HELZ_ENST00000580168.1_Silent_p.L706L	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CCTTTATGTAGAGATCAGCAG	0.343000													5	25					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49062390	49062390	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:49062390G>T	ENST00000326739.4	-	11	1273	c.1234C>A	c.(1234-1236)Cgc>Agc	p.R412S		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	412	IMP binding (By similarity).				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCCATACCGCGATATTTCTTT	0.542000													5	56					0.014758	0.0158932	1	1	0
HOXA3	3200	broad.mit.edu	37	7	27147855	27147855	+	Silent	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:27147855C>A	ENST00000396352.4	-	3	1210	c.1011G>T	c.(1009-1011)ggG>ggT	p.G337G	HOXA3_ENST00000317201.2_Silent_p.G337G|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	337					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						CGGGGGTGCCCCCTGCGCCCG	0.726000													7	20					5.18039e-06	6.10741e-06	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25468218	25468218	+	RNA	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr15:25468218G>C	ENST00000453082.2	+	0	766					NR_003343.1																						GGTGAGACTTGAGGAAGACTT	0.617000													3	23					0	0	1	0	0
TRIM21	6737	broad.mit.edu	37	11	4409627	4409627	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:4409627T>A	ENST00000254436.7	-	4	750	c.638A>T	c.(637-639)gAg>gTg	p.E213V	TRIM21_ENST00000543625.1_Missense_Mutation_p.E213V	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	213					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GGCCTCTTTCTCCCCCAGGAT	0.562000													14	130					0	0	1	0	0
PNPLA4	8228	broad.mit.edu	37	X	7870101	7870101	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:7870101G>A	ENST00000381042.4	-	6	729	c.559C>T	c.(559-561)Cga>Tga	p.R187*	PNPLA4_ENST00000537427.1_Nonsense_Mutation_p.R100*|PNPLA4_ENST00000444736.1_Nonsense_Mutation_p.R187*	NM_004650.2	NP_004641.1	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	187			R -> Q (in dbSNP:rs2231793).		lipid catabolic process		triglyceride lipase activity			kidney(1)|large_intestine(3)|lung(2)|prostate(1)	7		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				ATGTCCAGTCGTCCACTGAAG	0.512000													8	76					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12326017	12326017	+	Missense_Mutation	SNP	A	A	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr18:12326017A>C	ENST00000317702.5	+	4	1463	c.1229A>C	c.(1228-1230)gAg>gCg	p.E410A	TUBB6_ENST00000591909.1_Intron|TUBB6_ENST00000591208.1_3'UTR|TUBB6_ENST00000590967.1_Intron			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	410					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		GAGTTCACCGAGGCGGAGAGC	0.572000													7	164					0	0	1	0	0
ZXDA	7789	broad.mit.edu	37	X	57935351	57935351	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:57935351T>A	ENST00000358697.4	-	1	1716	c.1504A>T	c.(1504-1506)Att>Ttt	p.I502F		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	502	Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						AGGTGGGTAATGCTGTGGCCT	0.547000													5	63					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35985841	35985841	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:35985841G>A	ENST00000297866.5	+	10	1772	c.1706G>A	c.(1705-1707)cGc>cAc	p.R569H		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	569										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GCCATGACACGCACTCACAAT	0.453000													4	50					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30297202	30297202	+	Silent	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr6:30297202G>A	ENST00000376659.5	+	3	706	c.108G>A	c.(106-108)ctG>ctA	p.L36L	TRIM39_ENST00000396551.3_Silent_p.L36L|TRIM39_ENST00000396548.1_Silent_p.L36L|TRIM39_ENST00000396547.1_Silent_p.L36L|TRIM39_ENST00000376656.4_Silent_p.L36L|TRIM39_ENST00000540416.1_Silent_p.L36L	NM_172016.2	NP_742013.1			tripartite motif containing 39											ovary(3)	3						TGGAGTATCTGAAGGAACCTG	0.557000													9	143					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105886139	105886139	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:105886139G>C	ENST00000393359.2	-	11	2422	c.1996C>G	c.(1996-1998)Ccc>Gcc	p.P666A	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.P666A			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	666					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						CTCTCCATGGGCAGGCCAGCT	0.647000													4	24					0	0	1	0	0
VSIG8	391123	broad.mit.edu	37	1	159828685	159828685	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:159828685G>A	ENST00000368100.1	-	2	202	c.67C>T	c.(67-69)Cgg>Tgg	p.R23W	RP11-190A12.7_ENST00000544342.1_Missense_Mutation_p.A30V	NM_001013661.1	NP_001013683.1	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	23	Ig-like V-type 1.					integral to membrane				central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	8	all_hematologic(112;0.0597)					CCGTTGATCCGCACAGCAGAC	0.587000													3	34					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29041259	29041259	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr18:29041259G>T	ENST00000257189.4	+	8	966	c.883G>T	c.(883-885)Gaa>Taa	p.E295*		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	295	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGATTTGGATGAAGAGTACAC	0.338000													9	21					7.48243e-07	9.0111e-07	1	1	0
ZNF250	58500	broad.mit.edu	37	8	146108192	146108192	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr8:146108192T>C	ENST00000292579.7	-	6	507	c.391A>G	c.(391-393)Aca>Gca	p.T131A	ZNF250_ENST00000543949.1_Intron|ZNF250_ENST00000342660.6_Intron|ZNF250_ENST00000417550.2_Missense_Mutation_p.T126A	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		CTCAAGTCTGTATTTTGACTC	0.383000													6	84					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587708	43587708	+	RNA	SNP	A	A	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:43587708A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							AACAACCACCATCTCCAAATC	0.348000													4	21					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147744204	147744204	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:147744204C>T	ENST00000370460.2	+	3	1435	c.956C>T	c.(955-957)tCa>tTa	p.S319L	AFF2_ENST00000342251.3_Missense_Mutation_p.S315L|AFF2_ENST00000370457.5_Missense_Mutation_p.S315L|AFF2_ENST00000370458.1_Missense_Mutation_p.S315L	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	319					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAATCTGTCATTTGGAACA	0.443000													5	62					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264485	155264485	+	Silent	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:155264485G>A	ENST00000392414.3	-	6	773	c.660C>T	c.(658-660)ggC>ggT	p.G220G	PKLR_ENST00000342741.4_Silent_p.G251G	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	251					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity	p.G251G(1)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GCAAGTTCACGCCCTTCCGGC	0.672000													6	37					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320607	79320607	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:79320607T>C	ENST00000428286.1	-	8	6706	c.5506A>G	c.(5506-5508)Ata>Gta	p.I1836V	PRUNE2_ENST00000376718.3_Missense_Mutation_p.I2195V			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2195					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCACCGTTTATTTCAGAAGGT	0.458000													10	70					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18023035	18023035	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:18023035C>T	ENST00000205890.5	+	2	1259	c.921C>T	c.(919-921)taC>taT	p.Y307Y		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	307	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCTACGGCTACGGCTACGACG	0.617000													18	107					0	0	1	0	0
CCDC24	149473	broad.mit.edu	37	1	44461719	44461719	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:44461719C>T	ENST00000372318.3	+	9	982	c.811C>T	c.(811-813)Cga>Tga	p.R271*	SLC6A9_ENST00000372306.3_Intron|CCDC24_ENST00000486064.1_3'UTR|SLC6A9_ENST00000372307.3_Intron	NM_152499.1	NP_689712.1	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	271										endometrium(3)|large_intestine(2)|lung(3)|stomach(1)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCCCTACCTTCGACCTCGAGG	0.677000													8	68					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186506920	186506920	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:186506920C>T	ENST00000323963.5	+	11	1150	c.1086C>T	c.(1084-1086)ggC>ggT	p.G362G	EIF4A2_ENST00000356531.5_Silent_p.G267G|EIF4A2_ENST00000440191.2_Silent_p.G363G			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	362	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		ACAGAATTGGCAGAGGGGGTC	0.398000			T	BCL6	NHL								10	73					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328152	88328152	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr13:88328152C>A	ENST00000325089.6	+	2	728	c.509C>A	c.(508-510)cCc>cAc	p.P170H	SLITRK5_ENST00000400028.3_Intron	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	170						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTCATTGAACCCAATGCTTTT	0.423000													5	39					1.23904e-05	1.43064e-05	1	1	0
OR2A12	346525	broad.mit.edu	37	7	143792587	143792587	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:143792587G>C	ENST00000408949.2	+	1	447	c.387G>C	c.(385-387)ttG>ttC	p.L129F		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					GTCACCCCTTGCAATACACCC	0.428000													18	74					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346527	29346527	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr15:29346527C>A	ENST00000558402.1	+	5	1039	c.440C>A	c.(439-441)cCg>cAg	p.P147Q	APBA2_ENST00000561069.1_Missense_Mutation_p.P147Q|APBA2_ENST00000411764.1_Missense_Mutation_p.P147Q|APBA2_ENST00000558330.1_Missense_Mutation_p.P147Q|APBA2_ENST00000558259.1_Missense_Mutation_p.P147Q			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	147					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TCGGCGGGCCCGCACCCCCAC	0.667000													4	68					0.217242	0.219199	1	1	0
LCOR	84458	broad.mit.edu	37	10	98708926	98708926	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr10:98708926C>G	ENST00000540664.1	+	6	655	c.112C>G	c.(112-114)Cca>Gca	p.P38A	LCOR_ENST00000498444.1_3'UTR|LCOR_ENST00000371097.4_Missense_Mutation_p.P38A|LCOR_ENST00000356016.3_Missense_Mutation_p.P38A|LCOR_ENST00000371103.3_Missense_Mutation_p.P38A	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		GAAAGCATCTCCAGTCACCAC	0.498000													6	96					0	0	1	0	0
MC2R	4158	broad.mit.edu	37	18	13884723	13884723	+	Silent	SNP	G	G	T	rs141349908	byFrequency	TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr18:13884723G>T	ENST00000327606.3	-	2	975	c.795C>A	c.(793-795)atC>atA	p.I265I		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	265					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	CATTGCACATGATCAACATGC	0.517000													5	52					0.014758	0.0158932	1	1	0
ANGEL2	90806	broad.mit.edu	37	1	213178425	213178425	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:213178425T>A	ENST00000366962.3	-	5	1238	c.1084A>T	c.(1084-1086)Agt>Tgt	p.S362C	ANGEL2_ENST00000540642.1_Missense_Mutation_p.S236C|ANGEL2_ENST00000544555.1_Missense_Mutation_p.S193C|ANGEL2_ENST00000360506.2_Missense_Mutation_p.S193C|ANGEL2_ENST00000535388.1_Missense_Mutation_p.S193C	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	362										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TTTATGAAACTATATAGTGGA	0.413000													6	47					0	0	1	0	0
MRAS	22808	broad.mit.edu	37	3	138121022	138121022	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr3:138121022C>T	ENST00000289104.4	+	6	1185	c.538C>T	c.(538-540)Ccg>Tcg	p.P180S	MRAS_ENST00000474559.1_Missense_Mutation_p.P180S|MRAS_ENST00000464896.1_Missense_Mutation_p.P104S|MRAS_ENST00000423968.2_Missense_Mutation_p.P180S	NM_001085049.2|NM_001252090.1|NM_001252091.1|NM_012219.4	NP_001078518.1|NP_001239019.1|NP_001239020.1|NP_036351.3	O14807	RASM_HUMAN	muscle RAS oncogene homolog	180					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			kidney(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	14						GCAACAGATTCCGGAAAAAAG	0.507000													6	48					0	0	1	0	0
FBXO11	80204	broad.mit.edu	37	2	48050414	48050414	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:48050414C>G	ENST00000403359.3	-	12	1556	c.1484G>C	c.(1483-1485)tGt>tCt	p.C495S	FBXO11_ENST00000434523.2_5'UTR|FBXO11_ENST00000402508.1_Missense_Mutation_p.C411S|FBXO11_ENST00000316377.4_Missense_Mutation_p.C411S	NM_001190274.1	NP_001177203.1	Q86XK2	FBX11_HUMAN	F-box protein 11	495					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.0?(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTGAATTTCACATCGAACCAC	0.373000			"""Mis, F, D"""		DLBCL								3	26					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734961	12734961	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:12734961G>C	ENST00000380682.1	+	15	2889	c.2383G>C	c.(2383-2385)Gag>Cag	p.E795Q		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	795					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TGATGACAATGAGGATGACTT	0.562000													11	184					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688518	109688518	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:109688518A>T	ENST00000277225.5	+	3	2614	c.2325A>T	c.(2323-2325)agA>agT	p.R775S	ZNF462_ENST00000457913.1_Missense_Mutation_p.R775S			Q96JM2	ZN462_HUMAN	zinc finger protein 462	775					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCAACTTCAGAAACATCACCC	0.463000													5	52					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16504268	16504268	+	Nonstop_Mutation	SNP	A	A	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr4:16504268A>C	ENST00000304523.5	-	8	1443	c.1120T>G	c.(1120-1122)Taa>Gaa	p.*374E	RP11-446J8.1_ENST00000512370.1_RNA|LDB2_ENST00000515064.1_Nonstop_Mutation_p.*372E|LDB2_ENST00000441778.2_3'UTR|LDB2_ENST00000502640.1_3'UTR	NM_001290.3	NP_001281.1	O43679	LDB2_HUMAN	LIM domain binding 2	0							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CGATCATCTTATTGGGAAGCC	0.488000													16	183					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38176670	38176670	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chrX:38176670C>G	ENST00000378505.2	-	6	694	c.518G>C	c.(517-519)gGt>gCt	p.G173A	RPGR_ENST00000309513.3_Missense_Mutation_p.G173A|RPGR_ENST00000342811.3_Missense_Mutation_p.G173A|RPGR_ENST00000339363.3_Missense_Mutation_p.G173A|RPGR_ENST00000318842.7_Missense_Mutation_p.G173A|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000338898.3_Missense_Mutation_p.G173A	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	173			G -> R (in RP3 and RPDSI).		intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						ATTTTTTAAACCAATTTGCCC	0.398000													3	24					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71939464	71939464	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:71939464C>G	ENST00000298229.2	+	3	523	c.319C>G	c.(319-321)Cag>Gag	p.Q107E	INPPL1_ENST00000541756.1_5'UTR|INPPL1_ENST00000538751.1_5'UTR	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	107	SH2.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CCAGCCCAACCAGGGCCTTGT	0.662000													6	102					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116412045	116412045	+	Splice_Site	SNP	T	T	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:116412045T>G	ENST00000397752.3	+	14	3228		c.e14+2		MET_ENST00000318493.6_Splice_Site	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene						axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.?(3)|p.982_1028del47(1)		NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTCCAGAAGGTATATTTCAGT	0.343000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				7	19					0	0	1	0	0
CXCL9	4283	broad.mit.edu	37	4	76924829	76924829	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr4:76924829C>T	ENST00000264888.5	-	4	338	c.300G>A	c.(298-300)aaG>aaA	p.K100K	RP11-630D6.5_ENST00000501239.2_RNA	NM_002416.1	NP_002407.1	Q07325	CXCL9_HUMAN	chemokine (C-X-C motif) ligand 9	100					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity	p.K100N(1)		large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(1)	11			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTTTCCCATTCTTTTGCTTTT	0.353000													3	36					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189943259	189943259	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:189943259C>A	ENST00000374866.3	-	16	1316	c.1042G>T	c.(1042-1044)Ggg>Tgg	p.G348W		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	348					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCTGTGGCCCAAGTCTCCCT	0.413000													10	111					9.70103e-10	1.19397e-09	1	1	0
KCTD1	284252	broad.mit.edu	37	18	24035843	24035843	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr18:24035843C>G	ENST00000417602.1	-	5	2461	c.2462G>C	c.(2461-2463)aGa>aCa	p.R821T	KCTD1_ENST00000579973.1_Missense_Mutation_p.R213T|KCTD1_ENST00000408011.3_Missense_Mutation_p.R213T|KCTD1_ENST00000580059.1_Missense_Mutation_p.R213T|KCTD1_ENST00000317932.7_Missense_Mutation_p.R213T	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	213					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			TTCAAATCCTCTTTGCTGCAA	0.552000													4	70					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155147917	155147917	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:155147917A>T	ENST00000392451.2	+	2	202	c.119A>T	c.(118-120)tAc>tTc	p.Y40F	TRIM46_ENST00000368385.4_Missense_Mutation_p.Y40F|TRIM46_ENST00000368383.3_Missense_Mutation_p.Y40F|TRIM46_ENST00000545012.1_Intron|TRIM46_ENST00000543729.1_Missense_Mutation_p.Y47F|TRIM46_ENST00000368382.1_Missense_Mutation_p.Y17F|TRIM46_ENST00000334634.4_Missense_Mutation_p.Y40F|TRIM46_ENST00000468878.1_3'UTR			Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	40						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CAAGAGATGTACAAGCAGCCA	0.597000													11	124					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													6	69					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3349433	3349433	+	Silent	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr16:3349433G>A	ENST00000396862.1	-	2	3010	c.1182C>T	c.(1180-1182)acC>acT	p.T394T	TIGD7_ENST00000268674.2_Silent_p.T394T	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	394	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						CATTTGCTATGGTTATTTGTT	0.303000													8	80					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923323	24923323	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr15:24923323C>A	ENST00000329468.2	+	1	2783	c.2309C>A	c.(2308-2310)cCt>cAt	p.P770H		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGAGCCACCCCTCAACCCAAA	0.567000													7	199					0.27861	0.27861	1	1	0
CNN2	1265	broad.mit.edu	37	19	1037755	1037755	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr19:1037755C>T	ENST00000263097.4	+	7	1149	c.786C>T	c.(784-786)ttC>ttT	p.F262F	CNN2_ENST00000348419.3_Silent_p.F223F|CNN2_ENST00000606983.1_3'UTR|CNN2_ENST00000562958.2_Silent_p.F283F|CNN2_ENST00000565096.2_Silent_p.F251F	NM_004368.2	NP_004359.1	Q99439	CNN2_HUMAN	calponin 2	262					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGTCTTCGGCCTGGGCC	0.647000													16	203					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685396	100685396	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr7:100685396C>A	ENST00000306151.4	+	3	10763	c.10699C>A	c.(10699-10701)Cgt>Agt	p.R3567S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3567	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCACTATGCGTATGTCTAC	0.473000													31	179					1.30897e-18	1.62894e-18	1	1	0
PLEKHH2	130271	broad.mit.edu	37	2	43968145	43968145	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:43968145C>A	ENST00000282406.4	+	21	3294	c.3184C>A	c.(3184-3186)Ctc>Atc	p.L1062I		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1062	MyTH4.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTCCTGTGGCTCCTCAGGCT	0.522000													7	84					0.0293803	0.0310434	1	1	0
ABCC3	8714	broad.mit.edu	37	17	48742525	48742525	+	Silent	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:48742525C>T	ENST00000285238.8	+	11	1430	c.1350C>T	c.(1348-1350)ccC>ccT	p.P450P	ABCC3_ENST00000427699.1_Silent_p.P450P	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	450	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	ACCTAGGTCCCTCTGTCCTGG	0.542000													9	62					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10450905	10450905	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr17:10450905G>A	ENST00000245503.5	-	4	619	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	MYH2_ENST00000397183.2_Missense_Mutation_p.P79S|MYH2_ENST00000532183.1_Missense_Mutation_p.P79S|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	79	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GGGTTCATGGGGAAGACCTGA	0.418000													14	125					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82533609	82533609	+	Splice_Site	SNP	A	A	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr15:82533609A>T	ENST00000268206.7	-	5	547		c.e5+1		EFTUD1_ENST00000359445.3_Splice_Site	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1						mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						ACAATCCATTACCTGTGGACA	0.438000													3	37					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120088	103120088	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:103120088T>C	ENST00000295269.4	+	3	1359	c.902T>C	c.(901-903)aTt>aCt	p.I301T		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	301					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ATCTCTGCAATTGAGCCACTC	0.448000													7	46					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756147	248756147	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:248756147T>C	ENST00000330500.2	-	1	953	c.923A>G	c.(922-924)cAg>cGg	p.Q308R		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGAGGTTTCTGCACGCTCAG	0.388000													3	37					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155653	12155653	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr19:12155653C>G	ENST00000602107.1	-	5	703	c.704G>C	c.(703-705)aGa>aCa	p.R235T	CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.R188T			C9JN71	ZN878_HUMAN	zinc finger protein 878	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TCTTTCATGTCTACGAACAGA	0.403000													6	124					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179437928	179437928	+	Missense_Mutation	SNP	T	T	C	rs56201325	by1000genomes	TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr2:179437928T>C	ENST00000589042.1	-	326	73155	c.72931A>G	c.(72931-72933)Acc>Gcc	p.T24311A	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.T22670A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T15246A|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T15371A|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T15438A|TTN_ENST00000342992.6_Missense_Mutation_p.T21743A|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22670	Fibronectin type-III 76.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATGGACTGGTAGGACTTGGT	0.423000													5	51					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475245	140475245	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr5:140475245C>T	ENST00000194155.4	+	1	1019	c.871C>T	c.(871-873)Cgc>Tgc	p.R291C		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		291	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAAGACATTCGCAAAACGTT	0.428000													9	55					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117387317	117387317	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr11:117387317G>T	ENST00000321322.6	-	8	1829	c.1828C>A	c.(1828-1830)Cgc>Agc	p.R610S	DSCAML1_ENST00000527706.1_Missense_Mutation_p.R340S	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	550	Ig-like C2-type 7.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ACCACCTGGCGGTGGTTGTCT	0.587000													3	20					0.115264	0.119533	1	1	0
NOTCH2	4853	broad.mit.edu	37	1	120458413	120458413	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr1:120458413G>C	ENST00000256646.2	-	34	7151	c.6932C>G	c.(6931-6933)cCt>cGt	p.P2311R		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2311					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGCCTTTAGGGATGAGCTG	0.622000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				5	101					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377709	77377709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr9:77377709delG	ENST00000451710.3	-	26	4115	c.3878delC	c.(3877-3879)cafs	p.P1293fs	TRPM6_ENST00000449912.2_Frame_Shift_Del_p.P1288fs|TRPM6_ENST00000376864.4_Frame_Shift_Del_p.P1293fs|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000361255.3_Frame_Shift_Del_p.P1288fs|TRPM6_ENST00000360774.1_Frame_Shift_Del_p.P1293fs			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1293					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CTGCACTCTTGGGGGATGCCG	0.478													12	133	---	---	---	---					
TYSND1	219743	broad.mit.edu	37	10	71905929	71905931	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr10:71905929_71905931delCAG	ENST00000287078.6	-	1	411_413	c.412_414delCTG	c.(412-414)del	p.L138del	TYSND1_ENST00000335494.5_In_Frame_Del_p.L138del	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	138					proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						CCGGGCAGCTCAGCAGCAGCAGC	0.739													3	4	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546141	3546141	+	RNA	DEL	A	A	-	rs74546027		TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr16:3546141delA	ENST00000574423.2	+	0	111																											actccgtctcaaaaaaaaaaa	0.557													3	6	---	---	---	---					
PDYN	5173	broad.mit.edu	37	20	1961527	1961528	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-A47G-01A-21D-A24D-08	TCGA-44-A47G-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26332eb0-30bc-4ad1-b614-99940fa392fc	8ab5382a-817e-4d2a-a139-3a9f65b795fd	g.chr20:1961527_1961528insA	ENST00000217305.2	-	4	431_432	c.206_207insT	c.(205-207)tacfs	p.Y69fs	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Frame_Shift_Ins_p.Y69fs|PDYN_ENST00000539905.1_Frame_Shift_Ins_p.Y69fs	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	69					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGGAGGGGGTGAAAAAAGACAG	0.564													10	55	---	---	---	---					
