Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM66D	100132923	broad.mit.edu	37	8	11986719	11986719	+	RNA	SNP	G	G	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr8:11986719G>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGGATTTCAGGAAAAGCTGCA	0.522000													4	28					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186302290	186302290	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr1:186302290C>G	ENST00000367478.3	-	37	5715	c.5419G>C	c.(5419-5421)Gag>Cag	p.E1807Q		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1807					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity	p.E1807Q(1)|p.E1808Q(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GAAGGCCGCTCAACTGGTGAA	0.398000			T	NTRK1	papillary thyroid								4	53					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47772543	47772543	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr11:47772543T>C	ENST00000263773.5	-	6	843	c.831A>G	c.(829-831)atA>atG	p.I277M	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	277								p.I277M(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						CCTTAGAATATATGTCTGTAT	0.343000													6	70					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760104	167760104	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr2:167760104C>T	ENST00000409195.1	+	2	201	c.112C>T	c.(112-114)Cct>Tct	p.P38S	XIRP2_ENST00000295237.9_Missense_Mutation_p.P38S|XIRP2_ENST00000409756.2_Missense_Mutation_p.P38S|XIRP2_ENST00000420519.1_Missense_Mutation_p.P38S|XIRP2_ENST00000409728.1_Missense_Mutation_p.P38S|XIRP2_ENST00000409043.1_Missense_Mutation_p.P38S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding	p.Q37_P38>HS(2)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATTTTCCAGCCTCAGGAAAG	0.498000													5	43					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	72					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42507507	42507507	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr19:42507507G>A	ENST00000262895.3	-	18	2490	c.2491C>T	c.(2491-2493)Cgg>Tgg	p.R831W	GRIK5_ENST00000301218.4_Missense_Mutation_p.R831W|GRIK5_ENST00000593562.1_Missense_Mutation_p.R831W	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	831						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.R831W(2)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GCTGACCTCCGTGTGGACCAT	0.577000													7	50					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162766424	162766424	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr1:162766424C>G	ENST00000367917.3	+	3	357	c.289C>G	c.(289-291)Cca>Gca	p.P97A	HSD17B7_ENST00000254521.3_Missense_Mutation_p.P97A|HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000367913.1_Missense_Mutation_p.P97A			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	97					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	CATGCCTAATCCACAACTAAA	0.358000													3	94					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978332	69978332	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr4:69978332T>G	ENST00000305231.7	+	6	1514	c.1468T>G	c.(1468-1470)Tct>Gct	p.S490A	UGT2B7_ENST00000508661.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	490					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.S490A(1)		autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCAGTACCACTCTTTGGATGT	0.473000													6	142					0	0	1	0	0
MCU	90550	broad.mit.edu	37	10	74618992	74618992	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr10:74618992G>A	ENST00000536019.1	+	3	576	c.131G>A	c.(130-132)cGg>cAg	p.R44Q	MCU_ENST00000357157.6_Missense_Mutation_p.R93Q|MCU_ENST00000373053.3_Missense_Mutation_p.R93Q	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	93					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding	p.R93Q(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						CTACCATCCCGGCGTGAACGC	0.423000													11	103					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178408828	178408828	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr5:178408828C>T	ENST00000231188.5	-	10	2642	c.2464G>A	c.(2464-2466)Gtg>Atg	p.V822M	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.V822M	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	822					detection of visible light|visual perception	integral to plasma membrane		p.V822M(1)		NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CTCAAGGACACGGTTAGCGTG	0.572000													5	136					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39525666	39525666	+	Silent	SNP	C	C	T	rs35144407	byFrequency	TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr8:39525666C>T	ENST00000265707.5	+	14	1521	c.1476C>T	c.(1474-1476)aaC>aaT	p.N492N	ADAM18_ENST00000379866.1_Silent_p.N468N|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	492	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.N492N(1)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATTGCTATAACGGACAATGTC	0.378000													7	179					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71535077	71535077	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr15:71535077C>T	ENST00000355327.3	+	5	688	c.554C>T	c.(553-555)aCg>aTg	p.T185M	THSD4_ENST00000261862.6_Missense_Mutation_p.T185M			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	185	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity	p.T185M(1)		breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ACTGCACACACGCCACAGAGG	0.567000													7	133					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169159	90169159	+	Silent	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr4:90169159G>A	ENST00000333209.3	-	2	2621	c.2103C>T	c.(2101-2103)gaC>gaT	p.D701D		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	701								p.D701D(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGGACTCTGCGTCCAAGGATG	0.512000													7	48					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68160359	68160359	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr16:68160359C>T	ENST00000349223.5	+	3	1471	c.1247C>T	c.(1246-1248)tCa>tTa	p.S416L	NFATC3_ENST00000346183.3_Missense_Mutation_p.S416L|NFATC3_ENST00000329524.4_Missense_Mutation_p.S416L|NFATC3_ENST00000575270.1_Missense_Mutation_p.S416L|NFATC3_ENST00000535127.2_3'UTR	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	416	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding	p.S416L(2)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AGCACATCTTCATTACCTCCA	0.398000													4	64					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99723900	99723900	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr14:99723900G>A	ENST00000345514.2	-	2	601	c.335C>T	c.(334-336)cCg>cTg	p.P112L	BCL11B_ENST00000357195.3_Missense_Mutation_p.P112L|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	511						nucleus	zinc ion binding	p.P112L(1)		NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GATCTCCACCGGCTCGGACAC	0.607000			T	TLX3	T-ALL								7	57					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149875	153149875	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr5:153149875G>T	ENST00000285900.5	+	13	2513	c.2170G>T	c.(2170-2172)Gag>Tag	p.E724*	GRIA1_ENST00000448073.4_Nonsense_Mutation_p.E734*|GRIA1_ENST00000518783.1_Nonsense_Mutation_p.E734*|GRIA1_ENST00000518142.1_Nonsense_Mutation_p.E644*|GRIA1_ENST00000340592.5_Nonsense_Mutation_p.E724*|GRIA1_ENST00000521843.2_Nonsense_Mutation_p.E655*	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	724					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding	p.E724*(2)		NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CACCATGAATGAGTACATTGA	0.517000													4	57					0.150653	0.150653	1	1	0
FKBP3	2287	broad.mit.edu	37	14	45587247	45587247	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr14:45587247C>T	ENST00000216330.3	-	7	1014	c.604G>A	c.(604-606)Gga>Aga	p.G202R	FKBP3_ENST00000396062.3_Missense_Mutation_p.G202R			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	202	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity	p.G202R(1)		NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						TCAGGCTGTCCTTTCTTTCCG	0.398000													11	132					0	0	1	0	0
CYBB	1536	broad.mit.edu	37	X	37663304	37663304	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chrX:37663304G>C	ENST00000378588.4	+	9	1139	c.1072G>C	c.(1072-1074)Gtt>Ctt	p.V358L	CYBB_ENST00000536160.1_Missense_Mutation_p.V91L|TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000492288.1_3'UTR|CYBB_ENST00000545017.1_Missense_Mutation_p.V326L	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	358	FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity	p.V358L(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						TATCCGCATCGTTGGGGACTG	0.468000													5	64					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120812	38120812	+	Missense_Mutation	SNP	A	A	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr22:38120812A>C	ENST00000406386.3	+	7	2504	c.2249A>C	c.(2248-2250)cAg>cCg	p.Q750P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	750					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.Q750P(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TCCTGTGCCCAGCGGGACAAT	0.572000													3	39					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185902810	185902810	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr1:185902810G>A	ENST00000271588.4	+	11	1911	c.1682G>A	c.(1681-1683)aGa>aAa	p.R561K	HMCN1_ENST00000367492.2_Missense_Mutation_p.R561K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	561	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R561K(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AGAGATGTCAGACTGGCAGAG	0.443000													3	63					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12120213	12120213	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr6:12120213T>C	ENST00000379388.2	+	4	517	c.185T>C	c.(184-186)aTa>aCa	p.I62T		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	62					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding	p.I62T(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTGAAAAAAATACCAAAATCC	0.398000													7	108					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123109155	123109155	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr12:123109155G>A	ENST00000333479.7	+	63	6703	c.6526G>A	c.(6526-6528)Gct>Act	p.A2176T	KNTC1_ENST00000534995.1_Missense_Mutation_p.A97T|KNTC1_ENST00000450485.2_Missense_Mutation_p.A1101T|KNTC1_ENST00000436959.3_Missense_Mutation_p.A97T|HCAR1_ENST00000356987.2_Intron|KNTC1_ENST00000537348.1_3'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	2176					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding	p.A2176T(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTAGATGAAGCTTCAGTCTT	0.448000													5	31					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44238567	44238567	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr12:44238567G>A	ENST00000266534.3	+	2	240	c.113G>A	c.(112-114)aGc>aAc	p.S38N	TMEM117_ENST00000551577.1_Missense_Mutation_p.S38N	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	38						endoplasmic reticulum|integral to membrane		p.S38N(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GTTTCTCATAGCCAAACAGAA	0.393000													13	145					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118516248	118516248	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr11:118516248G>T	ENST00000361417.2	+	17	3707	c.3296G>T	c.(3295-3297)cGg>cTg	p.R1099L	PHLDB1_ENST00000356063.5_Missense_Mutation_p.R1052L|PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000524713.1_Missense_Mutation_p.R242L|PHLDB1_ENST00000527898.1_Missense_Mutation_p.R150L	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1099										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCTGCGGGGCGGGAGCGTGGG	0.667000													3	96					0.115264	0.118982	1	1	0
IMPDH1	3614	broad.mit.edu	37	7	128040468	128040468	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr7:128040468C>A	ENST00000338791.6	-	8	1055	c.705G>T	c.(703-705)atG>atT	p.M235I	IMPDH1_ENST00000348127.6_Missense_Mutation_p.M199I|IMPDH1_ENST00000354269.5_Missense_Mutation_p.M225I|IMPDH1_ENST00000419067.2_Missense_Mutation_p.M202I|IMPDH1_ENST00000378717.4_Missense_Mutation_p.M166I|IMPDH1_ENST00000480861.1_Missense_Mutation_p.M145I|IMPDH1_ENST00000343214.4_Missense_Mutation_p.M125I|IMPDH1_ENST00000470772.1_Missense_Mutation_p.M149I|IMPDH1_ENST00000496200.1_Missense_Mutation_p.M125I	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	150	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding	p.M235I(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	GCTTGCTGCCCATGGTGCCCG	0.622000													3	16					0.115264	0.118982	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168101995	168101995	+	Missense_Mutation	SNP	T	T	A			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr2:168101995T>A	ENST00000409195.1	+	9	4182	c.4093T>A	c.(4093-4095)Tca>Aca	p.S1365T	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.S1143T|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S1365T|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1190					actin cytoskeleton organization	cell junction	actin binding	p.S1365T(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TATTAATAAATCAGAAACTGT	0.368000													4	58					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760103	167760103	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr2:167760103G>T	ENST00000409195.1	+	2	200	c.111G>T	c.(109-111)caG>caT	p.Q37H	XIRP2_ENST00000295237.9_Missense_Mutation_p.Q37H|XIRP2_ENST00000409756.2_Missense_Mutation_p.Q37H|XIRP2_ENST00000420519.1_Missense_Mutation_p.Q37H|XIRP2_ENST00000409728.1_Missense_Mutation_p.Q37H|XIRP2_ENST00000409043.1_Missense_Mutation_p.Q37H	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding	p.Q37_P38>HS(2)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CAATTTTCCAGCCTCAGGAAA	0.493000													4	41					0.00024832	0.000274008	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48266967	48266967	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr7:48266967G>C	ENST00000435803.1	+	6	601	c.577G>C	c.(577-579)Gat>Cat	p.D193H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	193					transport	integral to membrane	ATP binding|ATPase activity	p.D138H(1)|p.D193H(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CACAAGCCATGATCATGTGGA	0.398000													4	85					0	0	1	0	0
LAMTOR4	389541	broad.mit.edu	37	7	99747177	99747180	+	Frame_Shift_Del	DEL	TACT	TACT	-			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr7:99747177_99747180delTACT	ENST00000441173.1	+	2	94_97	c.59_62delTACT	c.(58-63)ggfs	p.VL20fs	LAMTOR4_ENST00000341942.5_Frame_Shift_Del_p.VL20fs|LAMTOR4_ENST00000468582.1_3'UTR					late endosomal/lysosomal adaptor, MAPK and MTOR activator 4																		GGCTACCTGGTACTGAGTGAAGGT	0.569													16	192	---	---	---	---					
NPIPB11	728888	broad.mit.edu	37	16	29394767	29394769	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-50-5055-01A-01D-1625-08	TCGA-50-5055-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12fe153e-a8f7-49ec-9e0c-f680e2311cf6	bd0b53df-7024-4f75-9903-6d1215a6016c	g.chr16:29394767_29394769delTAT	ENST00000524087.1	-	8	1558_1560	c.1484_1486delATA	c.(1483-1488)atc>a	p.NI495del	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11																		GGTGTCTTGATATTATCATCTGC	0.586													4	9	---	---	---	---					
