Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NEK1	4750	broad.mit.edu	37	4	170523765	170523765	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:170523765C>G	ENST00000439128.2	-	2	657	c.17G>C	c.(16-18)aGa>aCa	p.R6T	NEK1_ENST00000511633.1_Missense_Mutation_p.R6T|NEK1_ENST00000510533.1_Missense_Mutation_p.R6T|NEK1_ENST00000507142.1_Missense_Mutation_p.R6T|NEK1_ENST00000512193.1_Missense_Mutation_p.R6T	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	6	Protein kinase.				cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CTTCTGTAGTCTAACATACTT	0.308000													13	83					0	0	0.00244969	0	0
CDH2	1000	broad.mit.edu	37	18	25570215	25570215	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:25570215C>A	ENST00000269141.3	-	10	1867	c.1444G>T	c.(1444-1446)Gca>Tca	p.A482S	CDH2_ENST00000399380.3_Missense_Mutation_p.A451S	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	482	Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GACACGGTTGCAGTTGACTGA	0.448000													19	49					1.01871e-10	4.54829e-10	0.00121646	1	0
PDCL3	79031	broad.mit.edu	37	2	101192814	101192814	+	Splice_Site	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:101192814A>G	ENST00000264254.6	+	6	955		c.e6-1			NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3						apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						TTTACCATATAGAGTTGGAAT	0.433000													14	69					0	0	0.00316338	0	0
CPED1	79974	broad.mit.edu	37	7	120935629	120935629	+	Missense_Mutation	SNP	C	C	T	rs147434701	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:120935629C>T	ENST00000310396.5	+	23	3471	c.3004C>T	c.(3004-3006)Cat>Tat	p.H1002Y		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATCGCCATATCATGTCAGAGG	0.378000													23	103					0	0	0.000878237	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952157	96952157	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:96952157T>C	ENST00000323853.5	-	29	3972	c.3895A>G	c.(3895-3897)Acc>Gcc	p.T1299A	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1299						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						AAAAGTTCGGTTGGAGGGGGG	0.507000													13	53					0	0	0.00185496	0	0
TEX10	54881	broad.mit.edu	37	9	103092397	103092397	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:103092397T>A	ENST00000374902.4	-	6	1481	c.1305A>T	c.(1303-1305)ttA>ttT	p.L435F	TEX10_ENST00000537512.1_Missense_Mutation_p.L370F|TEX10_ENST00000535814.1_Missense_Mutation_p.L438F	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	435						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CAGACAGTGTTAAATTCAGTA	0.388000													39	133					0	0	0.00148497	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602259	61602259	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:61602259C>A	ENST00000238508.3	+	8	1036	c.977C>A	c.(976-978)tCt>tAt	p.S326Y	AC009802.1_ENST00000599868.1_Intron	NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TCAGGAATGTCTTCAGCAAGA	0.428000													16	32					6.31663e-08	2.51402e-07	0.00316338	1	0
POTEF	728378	broad.mit.edu	37	2	130832747	130832747	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:130832747G>T	ENST00000357462.5	-	15	2391	c.2298C>A	c.(2296-2298)acC>acA	p.T766T	POTEF_ENST00000409914.2_Silent_p.T766T			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	766	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GGTACTTCAGGGTCAGGATGC	0.592000													15	61					1.99824e-07	7.77526e-07	0.000566183	1	0
OLFM4	10562	broad.mit.edu	37	13	53624108	53624108	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:53624108C>A	ENST00000219022.2	+	5	813	c.735C>A	c.(733-735)agC>agA	p.S245R		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	245	Olfactomedin-like.				cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GTATAGGGAGCTGTGGTCATG	0.388000													24	90					7.41945e-09	3.08516e-08	0.000878237	1	0
TRHDE	29953	broad.mit.edu	37	12	73015519	73015519	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:73015519G>T	ENST00000261180.4	+	15	2624	c.2528G>T	c.(2527-2529)aGc>aTc	p.S843I		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	843					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TGGATTTCCAGCAACAGGAAC	0.398000													15	43					2.35188e-11	1.08124e-10	0.00074312	1	0
PHKA1	5255	broad.mit.edu	37	X	71840645	71840645	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:71840645G>C	ENST00000339490.3	-	19	2367	c.2067C>G	c.(2065-2067)ttC>ttG	p.F689L	PHKA1_ENST00000373539.3_Missense_Mutation_p.F689L|PHKA1_ENST00000373545.3_Intron|PHKA1_ENST00000541944.1_Intron|PHKA1_ENST00000373542.4_Missense_Mutation_p.F689L	NM_001122670.1	NP_001116142.1	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	689					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CAGCAGCTTGGAACCGATCTA	0.512000													5	33					0	0	0.000602214	0	0
GCA	25801	broad.mit.edu	37	2	163215621	163215621	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:163215621C>G	ENST00000437150.2	+	6	683	c.522C>G	c.(520-522)ttC>ttG	p.F174L	GCA_ENST00000233612.4_Missense_Mutation_p.F155L|GCA_ENST00000429691.2_Intron	NM_012198.3	NP_036330.1	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	174	EF-hand 4.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	9						GCAGAATTTTCTTTGATGATT	0.308000													14	160					0	0	0.000566183	0	0
SMS	6611	broad.mit.edu	37	X	21996187	21996187	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:21996187G>T	ENST00000404933.2	+	6	867	c.615G>T	c.(613-615)ttG>ttT	p.L205F	SMS_ENST00000379404.1_Missense_Mutation_p.L152F|SMS_ENST00000415881.2_Missense_Mutation_p.L109F	NM_004595.4	NP_004586.2	P52788	SPSY_HUMAN	spermine synthase	205					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(2)	14					Spermine(DB00127)	GAGGCATATTGTGTGAAATAG	0.428000													15	59					6.31663e-08	2.51402e-07	0.00316338	1	0
DCHS2	54798	broad.mit.edu	37	4	155191131	155191131	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:155191131A>G	ENST00000357232.3	-	19	5132	c.5133T>C	c.(5131-5133)ccT>ccC	p.P1711P		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1711	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAATTGAGTCAGGAGCAAAAG	0.338000													18	94					0	0	0.00152264	0	0
SPTBN1	6711	broad.mit.edu	37	2	54858128	54858128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:54858128C>T	ENST00000333896.5	+	15	3290	c.2905C>T	c.(2905-2907)Cag>Tag	p.Q969*	SPTBN1_ENST00000356805.4_Nonsense_Mutation_p.Q982*	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	982					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CGAGTCCACCCAGGACCTGGG	0.587000													6	23					0	0	0.00116845	0	0
PTPRO	5800	broad.mit.edu	37	12	15669860	15669860	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:15669860A>T	ENST00000281171.4	+	9	2079	c.1749A>T	c.(1747-1749)atA>atT	p.I583I	PTPRO_ENST00000348962.2_Silent_p.I583I|PTPRO_ENST00000543886.1_Silent_p.I583I	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	583	Fibronectin type-III 6.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				ACTATGAAATAGCAGCAACTG	0.418000													31	113					0	0	0.00111076	0	0
LPA	4018	broad.mit.edu	37	6	160969685	160969685	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:160969685C>T	ENST00000447678.1	-	32	5100	c.4980G>A	c.(4978-4980)ctG>ctA	p.L1660L	LPA_ENST00000316300.5_Silent_p.L1660L	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4168	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGTTCATTGTCAGGCCACTGG	0.478000													13	36					0	0	0.00244969	0	0
TKTL2	84076	broad.mit.edu	37	4	164393100	164393100	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:164393100A>T	ENST00000280605.3	-	1	1947	c.1787T>A	c.(1786-1788)gTg>gAg	p.V596E		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	596						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ACGTTGAGGCACTCCTGACAC	0.463000													13	55					0	0	0.00244969	0	0
GRIK2	2898	broad.mit.edu	37	6	102503354	102503354	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:102503354G>T	ENST00000369138.1	+	15	2951	c.2461G>T	c.(2461-2463)Ggt>Tgt	p.G821C	GRIK2_ENST00000413795.1_Missense_Mutation_p.G821C|GRIK2_ENST00000369134.4_Missense_Mutation_p.G772C|GRIK2_ENST00000318991.6_Missense_Mutation_p.G821C|GRIK2_ENST00000369137.3_Missense_Mutation_p.G745C|GRIK2_ENST00000421544.1_Missense_Mutation_p.G821C	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	821					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TCAGAATATTGGTGGCATCTT	0.468000													31	61					3.67414e-24	1.98375e-23	0.0024448	1	0
OR2A5	393046	broad.mit.edu	37	7	143748240	143748240	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:143748240G>T	ENST00000408906.2	+	1	780	c.746G>T	c.(745-747)gGa>gTa	p.G249V		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TGCATGGTGGGACTCTTCTTT	0.587000													9	68					5.4927e-09	2.2977e-08	0.00448238	1	0
ACSL1	2180	broad.mit.edu	37	4	185678789	185678789	+	Splice_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:185678789C>A	ENST00000515030.1	-	20	2281	c.1956_splice	c.e20+1	p.Q652_splice	ACSL1_ENST00000507295.1_Splice_Site_p.Q618_splice|ACSL1_ENST00000513317.1_Splice_Site_p.Q652_splice|ACSL1_ENST00000504342.1_Splice_Site_p.Q652_splice|ACSL1_ENST00000454703.2_Splice_Site_p.Q481_splice|ACSL1_ENST00000437665.3_Splice_Site_p.Q481_splice|ACSL1_ENST00000281455.2_Splice_Site_p.Q652_splice			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	652					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAGGTCATACCTGTTCAAATG	0.348000													55	174					1.14385e-22	6.15208e-22	0.00361006	1	0
FLG	2312	broad.mit.edu	37	1	152280119	152280119	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152280119G>T	ENST00000368799.1	-	3	7278	c.7243C>A	c.(7243-7245)Ctc>Atc	p.L2415I	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2415	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTGGTAGAGGAAAGACCCT	0.612000									Ichthyosis				30	139					4.11147e-13	2.00957e-12	0.00375469	1	0
ATP2B2	491	broad.mit.edu	37	3	10413663	10413663	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:10413663A>T	ENST00000397077.1	-	11	1929	c.1354T>A	c.(1354-1356)Tgc>Agc	p.C452S	ATP2B2_ENST00000360273.2_Missense_Mutation_p.C497S|ATP2B2_ENST00000343816.4_Missense_Mutation_p.C483S|ATP2B2_ENST00000352432.4_Missense_Mutation_p.C497S|ATP2B2_ENST00000383800.4_Missense_Mutation_p.C452S			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	497					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TTGTCTGAGCAGATGGCTGTG	0.562000													20	41					0	0	0.00188189	0	0
WDR96	80217	broad.mit.edu	37	10	105990542	105990542	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:105990542T>A	ENST00000357060.3	-	2	240	c.125A>T	c.(124-126)tAc>tTc	p.Y42F	WDR96_ENST00000369720.1_5'UTR|WDR96_ENST00000278064.2_5'UTR|WDR96_ENST00000428666.1_Missense_Mutation_p.Y42F|WDR96_ENST00000369719.1_5'UTR	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	42										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCCACAAGGGTAGCAAATGGT	0.358000													10	72					0	0	0.000673444	0	0
ABCC6	368	broad.mit.edu	37	16	16276354	16276354	+	Missense_Mutation	SNP	C	C	A	rs72650701		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:16276354C>A	ENST00000205557.7	-	17	2191	c.2162G>T	c.(2161-2163)tGg>tTg	p.W721L	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	721	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCTCTCCAGCCAGGGTGGGTC	0.592000													11	28					0.000673444	0.00208468	0.000673444	1	0
FAM171A1	221061	broad.mit.edu	37	10	15255673	15255673	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:15255673C>A	ENST00000378116.4	-	8	1920	c.1914G>T	c.(1912-1914)ctG>ctT	p.L638L		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	638						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCTGGGAAGACAGGGGCTGGG	0.602000													16	22					0.000308642	0.000974917	0.00316338	1	0
SKP1	6500	broad.mit.edu	37	5	133509710	133509710	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:133509710G>A	ENST00000353411.6	-	2	187	c.4C>T	c.(4-6)Cct>Tct	p.P2S	SKP1_ENST00000517625.1_Missense_Mutation_p.P2S|SKP1_ENST00000522552.1_Missense_Mutation_p.P2S|SKP1_ENST00000522855.1_Missense_Mutation_p.P2S|SKP1_ENST00000521216.1_Missense_Mutation_p.P2S	NM_170679.2	NP_733779.1	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1	2					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTAATTGAAGGCATCTAAAAA	0.338000													13	42					0	0	0.00136819	0	0
COX7B2	170712	broad.mit.edu	37	4	46737207	46737207	+	Translation_Start_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:46737207C>A	ENST00000396533.1	-	4	253	c.3G>T	c.(1-3)atG>atT	p.M1I	COX7B2_ENST00000543208.1_5'UTR|COX7B2_ENST00000302930.5_Start_Codon_SNP_p.M1I|COX7B2_ENST00000355591.3_Start_Codon_SNP_p.M1I			Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2	1						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			large_intestine(1)|lung(4)	5						AGGGAAACATCATGAAGGATT	0.403000													13	46					2.32078e-09	9.76693e-09	0.00316338	1	0
TBC1D13	54662	broad.mit.edu	37	9	131568291	131568291	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:131568291A>G	ENST00000372648.5	+	10	1222	c.1072A>G	c.(1072-1074)Atg>Gtg	p.M358V	TBC1D13_ENST00000223865.8_Missense_Mutation_p.M233V|TBC1D13_ENST00000539497.1_Missense_Mutation_p.M177V	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	358						intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						CTGCTGCGCCATGCTCATGTG	0.622000													7	21					0	0	0.00198382	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829916	106829916	+	RNA	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:106829916A>G	ENST00000390616.2	-	0	98																											AGAAACCCACAGTGAGCCCTG	0.582000													11	16					0	0	0.000673444	0	0
SULF1	23213	broad.mit.edu	37	8	70539471	70539471	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:70539471T>C	ENST00000260128.4	+	16	2594	c.1877T>C	c.(1876-1878)aTc>aCc	p.I626T	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.I626T|SULF1_ENST00000419716.3_Missense_Mutation_p.I626T|SULF1_ENST00000458141.2_Missense_Mutation_p.I626T	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	626					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATGACTCTATCCATTGTGAG	0.388000													4	32					0	0	0.00024832	0	0
ZNF699	374879	broad.mit.edu	37	19	9407478	9407478	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9407478C>A	ENST00000591998.1	-	6	830	c.602G>T	c.(601-603)gGa>gTa	p.G201V	ZNF699_ENST00000308650.3_Missense_Mutation_p.G201V			Q32M78	ZN699_HUMAN	zinc finger protein 699	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GAAGGCCTTTCCACACTCATG	0.418000													24	99					8.24728e-16	4.16249e-15	0.00465635	1	0
GBP4	115361	broad.mit.edu	37	1	89655932	89655932	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:89655932G>A	ENST00000355754.6	-	7	1083	c.986C>T	c.(985-987)gCa>gTa	p.A329V		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	329						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		TGCTGTCACTGCATTCTCCAG	0.537000													15	44					0	0	0.00074312	0	0
AGT	183	broad.mit.edu	37	1	230846414	230846414	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:230846414C>A	ENST00000366667.4	-	2	397	c.183G>T	c.(181-183)aaG>aaT	p.K61N		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	61					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGTCTTTGGGCTTCCCGGCAT	0.572000													6	33					8.12818e-05	0.000265788	0.00198382	1	0
OR4B1	119765	broad.mit.edu	37	11	48238420	48238420	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:48238420C>A	ENST00000309562.2	+	1	77	c.59C>A	c.(58-60)gCt>gAt	p.A20D		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CAGGATCCAGCTGTGCAGAGT	0.507000													17	67					1.78486e-19	9.31204e-19	0.000958276	1	0
EML5	161436	broad.mit.edu	37	14	89091321	89091321	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:89091321C>G	ENST00000554922.1	-	36	5139	c.4891G>C	c.(4891-4893)Gaa>Caa	p.E1631Q	EML5_ENST00000380664.5_Missense_Mutation_p.E1623Q|EML5_ENST00000352093.5_Missense_Mutation_p.E1585Q|EML5_ENST00000553320.1_5'UTR	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1623						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CACGGCCTTTCCTTTCCCCCA	0.453000													9	17					0	0	0.00448238	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138719314	138719314	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:138719314C>T	ENST00000389532.4	-	8	1226	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M	CAMSAP1_ENST00000409386.3_Missense_Mutation_p.V399M|CAMSAP1_ENST00000312405.6_Missense_Mutation_p.V110M	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	388						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGCAGCTGCACGGGGGGCTGC	0.597000													5	18					0	0	0.000602214	0	0
NOS2	4843	broad.mit.edu	37	17	26086080	26086080	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:26086080G>T	ENST00000313735.6	-	26	3414	c.3181C>A	c.(3181-3183)Cgg>Agg	p.R1061R		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1061					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGCTGCTGCCGCAGGATGTCC	0.622000													4	12					1.23904e-05	4.26169e-05	0.000602214	1	0
UNC80	285175	broad.mit.edu	37	2	210650811	210650811	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:210650811C>A	ENST00000439458.1	+	5	702	c.622C>A	c.(622-624)Ctg>Atg	p.L208M	UNC80_ENST00000272845.5_Missense_Mutation_p.L208M|UNC80_ENST00000478701.1_3'UTR	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	208						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						CACCTTCCGTCTGGCCAGTGG	0.498000													19	79					8.34094e-07	3.09838e-06	0.00121646	1	0
SATL1	340562	broad.mit.edu	37	X	84363384	84363384	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:84363384G>A	ENST00000509231.1	-	1	670	c.591C>T	c.(589-591)ggC>ggT	p.G197G	SATL1_ENST00000332921.5_Silent_p.G10G|SATL1_ENST00000395409.3_Silent_p.G10G			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	10	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GTTGTTGCACGCCTGGTTGCC	0.572000													19	75					0	0	0.000958276	0	0
CALD1	800	broad.mit.edu	37	7	134613555	134613555	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:134613555G>A	ENST00000361388.2	+	4	588	c.122G>A	c.(121-123)cGg>cAg	p.R41Q	CALD1_ENST00000422748.1_Missense_Mutation_p.R41Q|CALD1_ENST00000495522.1_Missense_Mutation_p.R35Q|CALD1_ENST00000361675.2_Missense_Mutation_p.R41Q|CALD1_ENST00000361901.2_Missense_Mutation_p.R41Q|CALD1_ENST00000424922.1_Missense_Mutation_p.R35Q|CALD1_ENST00000417172.1_Missense_Mutation_p.R41Q|CALD1_ENST00000543443.1_Missense_Mutation_p.R46Q|CALD1_ENST00000393118.2_Missense_Mutation_p.R35Q	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	261	Myosin and calmodulin-binding (By similarity).|Poly-Arg.				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GCCCGGGAACGGCGCCGCCGA	0.587000													6	26					0	0	0.00307968	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717364	222717364	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:222717364C>A	ENST00000343410.6	-	2	547	c.489G>T	c.(487-489)agG>agT	p.R163S		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	163					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		GGGTACCGTCCCTTCCATGAG	0.567000													14	46					0.000151284	0.000491234	0.00185496	1	0
LARP1B	55132	broad.mit.edu	37	4	129043061	129043061	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:129043061G>T	ENST00000326639.6	+	11	1453	c.1242G>T	c.(1240-1242)ttG>ttT	p.L414F	LARP1B_ENST00000264584.5_Missense_Mutation_p.L367F|LARP1B_ENST00000427266.1_Missense_Mutation_p.L414F|LARP1B_ENST00000354456.3_5'UTR|LARP1B_ENST00000441387.1_Missense_Mutation_p.L414F|LARP1B_ENST00000512292.1_Missense_Mutation_p.L414F	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	414							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TTGATTTTTTGTTTGATGAAG	0.338000													10	46					1.76689e-08	7.26042e-08	0.000442599	1	0
EXOC4	60412	broad.mit.edu	37	7	133160178	133160178	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:133160178G>A	ENST00000253861.4	+	8	1308	c.1279G>A	c.(1279-1281)Gcc>Acc	p.A427T	EXOC4_ENST00000393161.2_Missense_Mutation_p.A427T|EXOC4_ENST00000539845.1_Missense_Mutation_p.A326T	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	427					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				AGAGTTTGCAGCCTTTTTTGC	0.378000													30	136					0	0	0.00375469	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745779	77745779	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:77745779G>T	ENST00000409088.3	-	3	1630	c.1216C>A	c.(1216-1218)Cca>Aca	p.P406T	LRRTM4_ENST00000409093.1_Missense_Mutation_p.P406T|LRRTM4_ENST00000409911.1_Missense_Mutation_p.P407T|LRRTM4_ENST00000409884.1_Missense_Mutation_p.P406T|LRRTM4_ENST00000409282.1_Missense_Mutation_p.P407T	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	406						integral to membrane		p.P406T(2)		autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TGAAACCCTGGGGAAGGGCTT	0.498000													9	39					7.48243e-07	2.80944e-06	0.000442599	1	0
PSAT1	29968	broad.mit.edu	37	9	80916926	80916926	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:80916926G>T	ENST00000376588.3	+	3	246	c.178G>T	c.(178-180)Gtg>Ttg	p.V60L	PSAT1_ENST00000347159.2_Missense_Mutation_p.V60L	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	60					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	AGAGAATCTTGTGCGGGAATT	0.328000													15	34					6.31663e-08	2.51402e-07	0.00316338	1	0
ZMYM4	9202	broad.mit.edu	37	1	35862216	35862216	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:35862216T>A	ENST00000314607.6	+	19	3055	c.2975T>A	c.(2974-2976)aTa>aAa	p.I992K	ZMYM4_ENST00000373297.2_Missense_Mutation_p.I903K	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	992					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTTGTTCCCATACCTCTTCAC	0.393000													18	73					0	0	0.00121646	0	0
SEMA5A	9037	broad.mit.edu	37	5	9202174	9202174	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:9202174G>A	ENST00000382496.5	-	9	1490	c.825C>T	c.(823-825)cgC>cgT	p.R275R		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	275	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AGCAGTTCAGGCGAGCCTTCA	0.522000													22	45					0	0	0.00278032	0	0
DNAH3	55567	broad.mit.edu	37	16	21073854	21073854	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:21073854C>A	ENST00000261383.3	-	25	3668	c.3669G>T	c.(3667-3669)tcG>tcT	p.S1223S	DNAH3_ENST00000415178.1_Silent_p.S1223S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1223	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTTCTTTTTCCGAGCTGATCA	0.428000													24	111					1.85244e-09	7.86723e-09	0.00332997	1	0
SCN2A	6326	broad.mit.edu	37	2	166179956	166179956	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:166179956C>A	ENST00000357398.3	+	12	2252	c.1962C>A	c.(1960-1962)gtC>gtA	p.V654V	SCN2A_ENST00000375427.2_Silent_p.V654V|SCN2A_ENST00000375437.2_Silent_p.V654V|SCN2A_ENST00000283256.6_Silent_p.V654V			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	654					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	ATGGTGTGGTCTCCCTGGTCG	0.582000													4	11					0.000602214	0.00186834	0.000602214	1	0
SMPDL3A	10924	broad.mit.edu	37	6	123122474	123122474	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:123122474C>A	ENST00000368440.4	+	4	668	c.491C>A	c.(490-492)aCc>aAc	p.T164N	SMPDL3A_ENST00000539041.1_Missense_Mutation_p.T33N	NM_006714.3	NP_006705.1	Q92484	ASM3A_HUMAN	sphingomyelin phosphodiesterase, acid-like 3A	164					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity			breast(1)|cervix(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(226;0.236)		CCTGTAGTCACCAGTAAAGTG	0.373000													39	96					2.40228e-13	1.1783e-12	0.00321405	1	0
CNTN3	5067	broad.mit.edu	37	3	74347277	74347277	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:74347277C>A	ENST00000263665.6	-	17	2259	c.2232G>T	c.(2230-2232)ggG>ggT	p.G744G		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	744	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AGGTGGTAACCCCAAGAGGGC	0.453000													11	44					0.000978159	0.00300789	0.000978159	1	0
PCDH9	5101	broad.mit.edu	37	13	67205364	67205364	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:67205364A>G	ENST00000544246.1	-	4	4009	c.3318T>C	c.(3316-3318)gaT>gaC	p.D1106D	PCDH9_ENST00000456367.1_Silent_p.D1072D|PCDH9_ENST00000328454.5_Silent_p.D1072D|PCDH9_ENST00000377865.2_Silent_p.D1106D	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1106					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CAGAGTTGCCATCTGCTTCAG	0.478000													11	81					0	0	0.00136819	0	0
ATRX	546	broad.mit.edu	37	X	76845317	76845317	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:76845317G>C	ENST00000373344.5	-	27	6418	c.6204C>G	c.(6202-6204)ccC>ccG	p.P2068P	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Silent_p.P2030P	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2068	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TATAAATAAGGGGTTTATCTT	0.308000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						5	40					0	0	0.00116845	0	0
MUC7	4589	broad.mit.edu	37	4	71347308	71347308	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:71347308G>C	ENST00000413702.1	+	4	1135	c.847G>C	c.(847-849)Gcc>Ccc	p.A283P	MUC7_ENST00000304887.5_Missense_Mutation_p.A283P|MUC7_ENST00000456088.1_Missense_Mutation_p.A283P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	283	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			GACCACAGCTGCCCCACCCAC	0.577000													43	142					0	0	0.0025221	0	0
EFCAB13	124989	broad.mit.edu	37	17	45518003	45518003	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:45518003C>A	ENST00000331493.2	+	25	3256	c.2845C>A	c.(2845-2847)Cac>Aac	p.H949N		NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		TATAAAACAACACAAGATTAG	0.313000													14	81					0.000219431	0.000702685	0.00244969	1	0
PCDH18	54510	broad.mit.edu	37	4	138451383	138451383	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:138451383T>A	ENST00000344876.4	-	1	2246	c.1860A>T	c.(1858-1860)atA>atT	p.I620I	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000412923.2_Silent_p.I620I|PCDH18_ENST00000507846.1_Silent_p.I400I	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	620	Cadherin 6.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TACCTGCTACTATGGCGCAGC	0.448000													60	212					0	0	0.00361006	0	0
FLG2	388698	broad.mit.edu	37	1	152325056	152325056	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152325056C>A	ENST00000388718.5	-	3	5278	c.5206G>T	c.(5206-5208)Ggg>Tgg	p.G1736W	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1736							calcium ion binding|structural molecule activity	p.G1736W(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGAGTACCCTTCACTGTCA	0.488000													70	219					8.29215e-51	4.63894e-50	0.00361006	1	0
ZFP30	22835	broad.mit.edu	37	19	38126323	38126323	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:38126323C>A	ENST00000351218.2	-	6	1676	c.1119G>T	c.(1117-1119)caG>caT	p.Q373H	ZFP30_ENST00000589018.1_Intron|ZFP30_ENST00000514101.2_Missense_Mutation_p.Q373H|ZFP30_ENST00000392144.1_Missense_Mutation_p.Q373H	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTATTCTCTGATGGAGAG	0.403000													21	66					5.26018e-13	2.56204e-12	0.00188189	1	0
LRIT2	340745	broad.mit.edu	37	10	85984201	85984201	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:85984201G>T	ENST00000372113.4	-	2	785	c.780C>A	c.(778-780)gcC>gcA	p.A260A	LRIT2_ENST00000538192.1_Silent_p.A260A	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	260	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						TGGTGATATTGGCACTGGGGG	0.542000													13	54					2.31682e-05	7.89079e-05	0.00316338	1	0
FAM47C	442444	broad.mit.edu	37	X	37028698	37028698	+	Missense_Mutation	SNP	C	C	T	rs144392292		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:37028698C>T	ENST00000358047.3	+	1	2267	c.2215C>T	c.(2215-2217)Cgc>Tgc	p.R739C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	739										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GTCCCATCTCCGCCCAGAGCC	0.637000													12	41					0	0	0.00185496	0	0
NPY2R	4887	broad.mit.edu	37	4	156136118	156136118	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:156136118G>C	ENST00000329476.3	+	2	1516	c.1027G>C	c.(1027-1029)Gag>Cag	p.E343Q	NPY2R_ENST00000506608.1_Missense_Mutation_p.E343Q	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	343					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTCCGCTGTGAGCAGCGGTT	0.512000													6	88					0	0	0.00307968	0	0
ZNF681	148213	broad.mit.edu	37	19	23927743	23927743	+	Silent	SNP	A	A	G	rs61397759		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:23927743A>G	ENST00000402377.3	-	4	750	c.609T>C	c.(607-609)tgT>tgC	p.C203C	ZNF681_ENST00000395385.3_Silent_p.C134C	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C134fs*5(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AGGCTTTTCCACAGTCTTCAC	0.294000													7	18					0	0	0.00448238	0	0
ADAM29	11086	broad.mit.edu	37	4	175898063	175898063	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:175898063G>T	ENST00000359240.3	+	5	2057	c.1387G>T	c.(1387-1389)Gat>Tat	p.D463Y	ADAM29_ENST00000445694.1_Missense_Mutation_p.D463Y|ADAM29_ENST00000404450.4_Missense_Mutation_p.D463Y|ADAM29_ENST00000514159.1_Missense_Mutation_p.D463Y	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	463	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CAATGAATGTGATCTTCCAGA	0.448000													7	55					8.12818e-05	0.000265788	0.00198382	1	0
ZNF534	147658	broad.mit.edu	37	19	52937229	52937229	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:52937229G>A	ENST00000332323.6	+	2	98	c.37G>A	c.(37-39)Gtg>Atg	p.V13M	ZNF534_ENST00000432303.2_Missense_Mutation_p.V13M|ZNF534_ENST00000301085.4_Missense_Mutation_p.V13M|ZNF534_ENST00000433050.1_Missense_Mutation_p.V13M	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						ATTCAGCGATGTGGCCATAGA	0.443000													14	59					0	0	0.00244969	0	0
ABCA1	19	broad.mit.edu	37	9	107595033	107595033	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:107595033T>C	ENST00000374736.3	-	12	1725	c.1331A>G	c.(1330-1332)gAc>gGc	p.D444G		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	444					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTGGTCATTGTCCCTGCTGTC	0.458000													12	48					0	0	0.00316338	0	0
PTPRK	5796	broad.mit.edu	37	6	128312532	128312532	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:128312532G>A	ENST00000368227.3	-	21	3303	c.2937C>T	c.(2935-2937)ccC>ccT	p.P979P	PTPRK_ENST00000368213.5_Silent_p.P968P|PTPRK_ENST00000368207.3_Silent_p.P994P|PTPRK_ENST00000368210.3_Silent_p.P980P|PTPRK_ENST00000532331.1_Silent_p.P984P|PTPRK_ENST00000368215.3_Silent_p.P961P|PTPRK_ENST00000368226.4_Silent_p.P962P			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	961	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTTCATGAACGGGACCTACAA	0.338000													13	24					0	0	0.00185496	0	0
AKR1C3	8644	broad.mit.edu	37	10	5138693	5138693	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:5138693A>G	ENST00000380554.3	+	2	828	c.176A>G	c.(175-177)gAg>gGg	p.E59G	AKR1C3_ENST00000470862.2_3'UTR|AKR1C3_ENST00000439082.2_5'UTR|AKR1C3_ENST00000605149.1_Missense_Mutation_p.E36G	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	59					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	AATAATGAGGAGCAGGTTGGA	0.438000													10	72					0	0	0.000442599	0	0
FLG2	388698	broad.mit.edu	37	1	152324228	152324228	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152324228G>T	ENST00000388718.5	-	3	6106	c.6034C>A	c.(6034-6036)Cat>Aat	p.H2012N	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2012							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGTCCATGACCAGAGTGG	0.527000													90	236					4.4782e-45	2.49525e-44	0.00361006	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072290	17072290	+	Missense_Mutation	SNP	C	C	A	rs141686687		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:17072290C>A	ENST00000359963.3	-	1	1410	c.1151G>T	c.(1150-1152)gGg>gTg	p.G384V		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	384					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACTCCGCAGCCCCTGGGTGGT	0.567000													18	29					5.35267e-07	2.04842e-06	0.000958276	1	0
OR2L3	391192	broad.mit.edu	37	1	248224498	248224498	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248224498C>G	ENST00000359959.3	+	1	515	c.515C>G	c.(514-516)gCc>gGc	p.A172G	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAATCCAGGGCCATCAATCAT	0.468000													31	131					0	0	0.00178596	0	0
KLK2	3817	broad.mit.edu	37	19	51381809	51381809	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:51381809C>A	ENST00000325321.3	+	5	1005	c.780C>A	c.(778-780)aaC>aaA	p.N260K	KLK2_ENST00000391810.2_Missense_Mutation_p.N158K|KLK2_ENST00000358049.4_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	260					proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TCGCAGCCAACCCCTGAGTGC	0.557000			T	ETV4	prostate								17	71					1.33834e-09	5.73632e-09	0.000958276	1	0
SLC1A6	6511	broad.mit.edu	37	19	15082639	15082639	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:15082639G>A	ENST00000598504.1	-	5	1612	c.253C>T	c.(253-255)Cag>Tag	p.Q85*	SLC1A6_ENST00000430939.2_Missense_Mutation_p.P89L|SLC1A6_ENST00000221742.3_Nonsense_Mutation_p.Q85*|SLC1A6_ENST00000600144.1_Nonsense_Mutation_p.Q85*|SLC1A6_ENST00000544886.2_Nonsense_Mutation_p.Q85*	NM_001272087.1	NP_001259016.1	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	85					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	TACTTGATCTGGCGGTAGGTG	0.567000													10	57					0	0	0.00244969	0	0
SOX5	6660	broad.mit.edu	37	12	23818489	23818489	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:23818489G>A	ENST00000546136.1	-	6	783	c.781C>T	c.(781-783)Cag>Tag	p.Q261*	SOX5_ENST00000381381.2_Nonsense_Mutation_p.Q261*|SOX5_ENST00000537393.1_Nonsense_Mutation_p.Q239*|SOX5_ENST00000309359.1_Nonsense_Mutation_p.Q261*|SOX5_ENST00000545921.1_Nonsense_Mutation_p.Q264*|SOX5_ENST00000541536.1_Nonsense_Mutation_p.Q261*|SOX5_ENST00000451604.2_Nonsense_Mutation_p.Q274*			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	274					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						GGCGGCAGCTGACCTTGAACC	0.483000													20	63					0	0	0.00188189	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70956824	70956824	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:70956824G>T	ENST00000359655.4	+	8	1068	c.1008G>T	c.(1006-1008)acG>acT	p.T336T		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	336					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGTACACAACGGGGGAGGAAG	0.473000													17	86					4.96729e-08	1.99984e-07	0.00121646	1	0
DSG3	1830	broad.mit.edu	37	18	29039949	29039949	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:29039949C>A	ENST00000257189.4	+	6	742	c.659C>A	c.(658-660)aCt>aAt	p.T220N		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	220	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAAGTCCGTACTTTGACCAAT	0.438000													10	16					1.08611e-07	4.24985e-07	0.000978159	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1965194	1965194	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:1965194C>T	ENST00000382722.5	-	22	2498	c.2136G>A	c.(2134-2136)aaG>aaA	p.K712K	CACNA2D4_ENST00000587995.1_Silent_p.K687K|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000588077.1_Silent_p.K648K|CACNA2D4_ENST00000585708.1_Silent_p.K648K|CACNA2D4_ENST00000586184.1_Silent_p.K712K|CACNA2D4_ENST00000585732.1_Silent_p.K573K	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	712						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGTCTGGGTCCTTCCTGGTGA	0.577000													5	25					0	0	0.000602214	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812810	31812810	+	Nonsense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:31812810C>G	ENST00000334067.3	+	1	214	c.165C>G	c.(163-165)taC>taG	p.Y55*		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	55						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						AGGAGACCTACTGTGAGCCCA	0.502000													13	80					0	0	0.00185496	0	0
MTG1	92170	broad.mit.edu	37	10	135233639	135233639	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:135233639G>T	ENST00000468317.2	+	12	1245	c.990G>T	c.(988-990)cgG>cgT	p.R330R	MTG1_ENST00000317502.6_Silent_p.R325R|MTG1_ENST00000477902.2_Silent_p.R284R																							ACGTCCTGCGGGGCCACCCCC	0.637000													10	20					0.000442599	0.00138238	0.000442599	1	0
SAMD9	54809	broad.mit.edu	37	7	92733058	92733058	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:92733058C>A	ENST00000379958.2	-	3	2622	c.2353G>T	c.(2353-2355)Gca>Tca	p.A785S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	785						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CGGTTCATTGCCCCATAGGTG	0.388000													28	130					3.99451e-17	2.05327e-16	0.00178596	1	0
CCDC178	374864	broad.mit.edu	37	18	30926184	30926184	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:30926184C>G	ENST00000383096.3	-	9	831	c.649G>C	c.(649-651)Gtg>Ctg	p.V217L	CCDC178_ENST00000579947.1_Missense_Mutation_p.V217L|CCDC178_ENST00000406524.2_Missense_Mutation_p.V217L|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000403303.1_Missense_Mutation_p.V217L|CCDC178_ENST00000300227.8_Missense_Mutation_p.V217L|CCDC178_ENST00000402325.1_Missense_Mutation_p.V217L|CCDC178_ENST00000583930.1_Missense_Mutation_p.V217L					coiled-coil domain containing 178																		CCTTTCTGCACAGCCAATGGG	0.323000													24	56					0	0	0.00127121	0	0
TTN	7273	broad.mit.edu	37	2	179451991	179451991	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179451991A>G	ENST00000589042.1	-	307	64171	c.63947T>C	c.(63946-63948)gTt>gCt	p.V21316A	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V12251A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V12376A|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V19675A|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V18748A|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V12443A|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590743.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19675	Ig-like 113.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGGGGTAACGGTCGACCA	0.493000													14	44					0	0	0.00185496	0	0
UNC5D	137970	broad.mit.edu	37	8	35608192	35608192	+	Nonsense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:35608192T>A	ENST00000287272.2	+	12	1841	c.1821T>A	c.(1819-1821)taT>taA	p.Y607*	UNC5D_ENST00000453357.2_Nonsense_Mutation_p.Y671*|UNC5D_ENST00000420357.1_Nonsense_Mutation_p.Y609*|UNC5D_ENST00000416672.1_Nonsense_Mutation_p.Y681*|UNC5D_ENST00000404895.2_Nonsense_Mutation_p.Y676*|UNC5D_ENST00000449677.1_Nonsense_Mutation_p.Y252*			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	676	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGGGACCTATGCGCTCACTG	0.512000													13	78					0	0	0.00185496	0	0
SERPINB3	6317	broad.mit.edu	37	18	61328320	61328320	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:61328320C>A	ENST00000283752.5	-	2	274	c.131G>T	c.(130-132)gGa>gTa	p.G44V	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G44V	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	44					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						GTCTTTGGCTCCTAAGAGGAC	0.438000													28	97					5.60225e-13	2.71914e-12	0.00178596	1	0
KLHL38	340359	broad.mit.edu	37	8	124664033	124664033	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:124664033G>T	ENST00000325995.7	-	1	1157	c.1134C>A	c.(1132-1134)agC>agA	p.S378R	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	378										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						TATGGGCAGTGCTTCTGTGGG	0.552000													6	34					8.12818e-05	0.000265788	0.00198382	1	0
SYT10	341359	broad.mit.edu	37	12	33579112	33579112	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:33579112C>A	ENST00000228567.3	-	2	766	c.470G>T	c.(469-471)cGt>cTt	p.R157L	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	157						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TCTTTGCACACGTGCATGTTT	0.408000													41	175					2.47872e-24	1.34353e-23	0.0025221	1	0
KRT23	25984	broad.mit.edu	37	17	39092731	39092731	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:39092731C>G	ENST00000209718.3	-	2	549	c.125G>C	c.(124-126)cGc>cCc	p.R42P	KRT23_ENST00000436344.3_Intron|AC004231.2_ENST00000418393.1_RNA	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	42	Head.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				CAGGGAGATGCGGGCTCCCCC	0.706000													6	21					0	0	0.00198382	0	0
FBN1	2200	broad.mit.edu	37	15	48808532	48808532	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:48808532G>A	ENST00000316623.5	-	11	1630	c.1175C>T	c.(1174-1176)cCt>cTt	p.P392L		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	392					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AATTACCATAGGAACAGAGCA	0.483000													15	34					0	0	0.00316338	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819098	50819098	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:50819098G>A	ENST00000374115.3	+	1	752	c.312G>A	c.(310-312)gcG>gcA	p.A104A	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	104					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CGACAGCTGCGTGGCCAGCGG	0.682000													9	30					0	0	0.00448238	0	0
ZNF264	9422	broad.mit.edu	37	19	57724116	57724116	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:57724116A>T	ENST00000263095.6	+	4	2065	c.1651A>T	c.(1651-1653)Agc>Tgc	p.S551C	ZNF264_ENST00000536056.1_Missense_Mutation_p.S551C	NM_003417.4	NP_003408.1	O43296	ZN264_HUMAN	zinc finger protein 264	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	27		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CTTCAGTCGCAGCTCGTCCCT	0.458000													20	59					0	0	0.000958276	0	0
CDH16	1014	broad.mit.edu	37	16	66950032	66950032	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:66950032A>T	ENST00000299752.4	-	5	553	c.360T>A	c.(358-360)aaT>aaA	p.N120K	CDH16_ENST00000568632.1_Missense_Mutation_p.N120K|CDH16_ENST00000570262.1_Missense_Mutation_p.N40K|CDH16_ENST00000565796.1_Missense_Mutation_p.N120K|CDH16_ENST00000394055.3_Missense_Mutation_p.N120K	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	120	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCACCTGGTCATTCTCATCCT	0.577000													7	32					0	0	0.00307968	0	0
EDA	1896	broad.mit.edu	37	X	69255360	69255360	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:69255360G>T	ENST00000374552.4	+	8	1319	c.1077G>T	c.(1075-1077)aaG>aaT	p.K359N	EDA_ENST00000374553.2_Missense_Mutation_p.K357N|EDA_ENST00000524573.1_Missense_Mutation_p.K354N	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	359					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						CCCGGCAGAAGATCGCCGTCA	0.577000													6	40					0.00116845	0.00354607	0.00116845	1	0
TBC1D10A	83874	broad.mit.edu	37	22	30722752	30722752	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:30722752G>C	ENST00000215790.7	-	1	283	c.119C>G	c.(118-120)tCt>tGt	p.S40C	TBC1D10A_ENST00000403477.3_Missense_Mutation_p.S40C|TBC1D10A_ENST00000490449.1_5'UTR	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	40						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						AGACCCGAGAGAGCTGAGTTC	0.721000													5	20					0	0	0.000602214	0	0
MROH2B	133558	broad.mit.edu	37	5	41004995	41004995	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:41004995G>T	ENST00000399564.4	-	36	4342	c.3892C>A	c.(3892-3894)Cat>Aat	p.H1298N	MROH2B_ENST00000506092.2_Missense_Mutation_p.H853N	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AGATTCCCATGCTTCCAAAGG	0.527000													7	25					0.000274275	0.00086833	0.00448238	1	0
LAMA2	3908	broad.mit.edu	37	6	129636648	129636648	+	Silent	SNP	C	C	T	rs1063373		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:129636648C>T	ENST00000421865.2	+	25	3632	c.3583C>T	c.(3583-3585)Cta>Tta	p.L1195L		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1195	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCAGACCATTCTACCCCTGGT	0.463000													19	46					0	0	0.00152264	0	0
NXF4	55999	broad.mit.edu	37	X	101822111	101822111	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:101822111G>T	ENST00000360035.2	+	0	1864					NR_002216.1															endometrium(2)|lung(8)	10						GAAGGTGAGTGTCTATAGATT	0.468000													4	7					0.000602214	0.00186834	0.000602214	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253550	32253550	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:32253550A>G	ENST00000332378.4	-	1	324	c.294T>C	c.(292-294)acT>acC	p.T98T		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	98						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						GGCTGTAGGTAGTTGAGCAGG	0.567000													6	43					0	0	0.00116845	0	0
CRISP3	10321	broad.mit.edu	37	6	49696489	49696489	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:49696489C>A	ENST00000433368.2	-	8	830	c.761G>T	c.(760-762)aGg>aTg	p.R254M	CRISP3_ENST00000371159.4_Missense_Mutation_p.R262M|CRISP3_ENST00000393666.1_Missense_Mutation_p.R231M|CRISP3_ENST00000423399.2_Missense_Mutation_p.R141M|CRISP3_ENST00000263045.4_Missense_Mutation_p.R244M	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	231					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GCAACTGTCCCTGACCAACTG	0.388000													30	89					1.7881e-09	7.6172e-09	0.001512	1	0
DSC2	1824	broad.mit.edu	37	18	28651795	28651795	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:28651795C>G	ENST00000280904.6	-	13	2344	c.1901G>C	c.(1900-1902)cGt>cCt	p.R634P	DSC2_ENST00000251081.6_Missense_Mutation_p.R634P	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	634	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			ATAGGAAAGACGTGCTGCTGT	0.323000													12	34					0	0	0.00244969	0	0
OR10G7	390265	broad.mit.edu	37	11	123909438	123909438	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:123909438T>C	ENST00000330487.5	-	1	279	c.271A>G	c.(271-273)Atc>Gtc	p.I91V		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGGAAGGAGATAGTCCTGCCG	0.527000													21	118					0	0	0.00278032	0	0
C7	730	broad.mit.edu	37	5	40958249	40958249	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:40958249C>T	ENST00000313164.9	+	11	1734	c.1375C>T	c.(1375-1377)Cct>Tct	p.P459S		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	459	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				TCATTGCCGGCCTTGTCAAAA	0.488000													15	58					0	0	0.00244969	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912566	77912566	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:77912566G>T	ENST00000321110.1	-	2	1647	c.1352C>A	c.(1351-1353)cCt>cAt	p.P451H		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	451							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						AAAATGACCAGGATAACCACA	0.557000													6	22					8.12818e-05	0.000265788	0.00198382	1	0
KCNH7	90134	broad.mit.edu	37	2	163693067	163693067	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:163693067A>T	ENST00000332142.5	-	2	386	c.287T>A	c.(286-288)gTc>gAc	p.V96D	KCNH7_ENST00000328032.4_Missense_Mutation_p.V96D	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	96	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	ATAGTAGGTGACCTCCACTTT	0.418000													6	34					0	0	0.00198382	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912567	77912567	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:77912567G>T	ENST00000321110.1	-	2	1646	c.1351C>A	c.(1351-1353)Cct>Act	p.P451T		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	451							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						AAATGACCAGGATAACCACAG	0.557000													6	21					8.12818e-05	0.000265788	0.00198382	1	0
POT1	25913	broad.mit.edu	37	7	124503463	124503463	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:124503463C>A	ENST00000357628.3	-	8	1085	c.487G>T	c.(487-489)Gac>Tac	p.D163Y	POT1_ENST00000393329.1_Missense_Mutation_p.D32Y	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	163					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						CAAGTCAGGTCAAAATACTGC	0.403000													21	97					1.10513e-12	5.30845e-12	0.00229938	1	0
ZNF705A	440077	broad.mit.edu	37	12	8329900	8329900	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:8329900C>A	ENST00000359286.4	+	5	713	c.624C>A	c.(622-624)gcC>gcA	p.A208A		NM_001004328.2|NM_001278713.1	NP_001004328.1|NP_001265642.1	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(3)|stomach(4)	18				Kidney(36;0.0877)		GTGGAAAAGCCTTCACTCAGT	0.423000													27	82					6.70999e-13	3.23426e-12	0.00428921	1	0
TEX101	83639	broad.mit.edu	37	19	43920616	43920616	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43920616G>C	ENST00000602198.1	+	6	796	c.354G>C	c.(352-354)ctG>ctC	p.L118L	TEX101_ENST00000601707.1_3'UTR|TEX101_ENST00000598265.1_Silent_p.L100L|TEX101_ENST00000253435.7_Silent_p.L118L	NM_031451.4	NP_113639.4	Q9BY14	TX101_HUMAN	testis expressed 101	100						anchored to membrane|plasma membrane				large_intestine(1)|lung(12)|ovary(1)|skin(1)	15		Prostate(69;0.0199)				CTCCCGGCCTGATCGTGACCT	0.527000													28	143					0	0	0.00178596	0	0
OR4A16	81327	broad.mit.edu	37	11	55111429	55111429	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55111429C>A	ENST00000314721.2	+	1	803	c.753C>A	c.(751-753)ccC>ccA	p.P251P		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TTTTTGTTCCCTGTATTTTTA	0.373000													12	57					9.31168e-06	3.25092e-05	0.00185496	1	0
HMGB4	127540	broad.mit.edu	37	1	34330269	34330269	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:34330269C>G	ENST00000522796.1	+	4	2382	c.477C>G	c.(475-477)ctC>ctG	p.L159L	HMGB4_ENST00000519684.1_Silent_p.L159L|HMGB4_ENST00000425537.1_3'UTR|CSMD2_ENST00000373381.4_Intron			B2R4X7	B2R4X7_HUMAN	high mobility group box 4	159						nucleus	DNA binding			NS(1)|breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AACTTGAACTCTACCGTAAAC	0.488000													5	32					0	0	0.00116845	0	0
DDX58	23586	broad.mit.edu	37	9	32500928	32500928	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:32500928T>A	ENST00000379883.2	-	2	273	c.116A>T	c.(115-117)cAg>cTg	p.Q39L	DDX58_ENST00000542096.1_5'UTR|DDX58_ENST00000379882.1_Intron|DDX58_ENST00000545044.1_5'UTR|DDX58_ENST00000379868.1_5'UTR	NM_014314.3	NP_055129.2	O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	39	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CTGAATATACTGCACCTCTTC	0.443000													17	72					0	0	0.000958276	0	0
NLRP12	91662	broad.mit.edu	37	19	54313761	54313761	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:54313761C>A	ENST00000324134.6	-	3	1320	c.1152G>T	c.(1150-1152)gcG>gcT	p.A384A	NLRP12_ENST00000391775.3_Silent_p.A384A|NLRP12_ENST00000391773.1_Silent_p.A384A|NLRP12_ENST00000391772.1_Silent_p.A384A|NLRP12_ENST00000535162.1_Silent_p.A384A|NLRP12_ENST00000354278.3_Silent_p.A384A|NLRP12_ENST00000345770.5_Silent_p.A384A|NLRP12_ENST00000351894.4_Silent_p.A384A	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	384	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGACTTGGCCCGCCTGCTCTG	0.562000													34	139					5.66738e-07	2.16292e-06	0.00128727	1	0
TP53	7157	broad.mit.edu	37	17	7577570	7577570	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:7577570C>T	ENST00000420246.2	-	7	843	c.711G>A	c.(709-711)atG>atA	p.M237I	TP53_ENST00000413465.2_Missense_Mutation_p.M237I|TP53_ENST00000455263.2_Missense_Mutation_p.M237I|TP53_ENST00000269305.4_Missense_Mutation_p.M237I|TP53_ENST00000445888.2_Missense_Mutation_p.M237I|TP53_ENST00000359597.4_Missense_Mutation_p.M237I	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	237	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(109)|p.0?(8)|p.?(5)|p.M144I(4)|p.M237_N239delMCN(4)|p.Y236_M237delYM(1)|p.H233fs*6(1)|p.M144_N146delMCN(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.H233_C242del10(1)|p.M237fs*1(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	34					0	0	0.00448238	0	0
MT1HL1	645745	broad.mit.edu	37	1	237167558	237167558	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:237167558G>C	ENST00000464121.2	-	1	160	c.115C>G	c.(115-117)Ctg>Gtg	p.L39V		NM_001276687.1	NP_001263616.1			metallothionein 1H-like 1																		GCACAGCCCAGGGGGCAACAG	0.622000													14	28					0	0	0.00316338	0	0
CD163	9332	broad.mit.edu	37	12	7632483	7632483	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:7632483C>T	ENST00000359156.4	-	16	3655	c.3453G>A	c.(3451-3453)aaG>aaA	p.K1151K	CD163_ENST00000396620.3_3'UTR|CD163_ENST00000432237.2_3'UTR|CD163_ENST00000541972.1_3'UTR	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	1151					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TCCCATTTTCCTTTTCAGTGT	0.403000													17	63					0	0	0.000566183	0	0
ARVCF	421	broad.mit.edu	37	22	19960554	19960554	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:19960554G>A	ENST00000263207.3	-	15	2735	c.2444C>T	c.(2443-2445)tCg>tTg	p.S815L	ARVCF_ENST00000401994.1_Missense_Mutation_p.S752L|ARVCF_ENST00000406522.1_Missense_Mutation_p.S746L|ARVCF_ENST00000406259.1_Missense_Mutation_p.S809L|ARVCF_ENST00000344269.3_Missense_Mutation_p.S752L	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	815					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					TTCGCGTACCGATTGGCTGTG	0.687000													5	17					0	0	0.00116845	0	0
YTHDC2	64848	broad.mit.edu	37	5	112849603	112849603	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:112849603C>G	ENST00000161863.4	+	1	224	c.11C>G	c.(10-12)cCg>cGg	p.P4R	YTHDC2_ENST00000515883.1_Missense_Mutation_p.P4R	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	4							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ATGTCCAGGCCGAGCAGCGTC	0.716000													5	8					0	0	0.00116845	0	0
FAF1	11124	broad.mit.edu	37	1	50941222	50941222	+	Missense_Mutation	SNP	T	T	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:50941222T>G	ENST00000396153.2	-	18	2234	c.1783A>C	c.(1783-1785)Aag>Cag	p.K595Q	FAF1_ENST00000545823.1_Missense_Mutation_p.K353Q|FAF1_ENST00000371778.4_Missense_Mutation_p.K595Q	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	595	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		ATCTGGAGCTTGTTGCTGGCC	0.512000													7	49					0	0	0.00198382	0	0
UBE2D3	7323	broad.mit.edu	37	4	103730964	103730964	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:103730964G>A	ENST00000453744.2	-	3	586	c.73C>T	c.(73-75)Cca>Tca	p.P25S	UBE2D3_ENST00000394804.2_Missense_Mutation_p.P25S|UBE2D3_ENST00000350435.7_Missense_Mutation_p.P19S|UBE2D3_ENST00000338145.3_Missense_Mutation_p.P25S|UBE2D3_ENST00000394803.5_Missense_Mutation_p.P25S|UBE2D3_ENST00000505207.1_5'UTR|UBE2D3_ENST00000507845.1_5'UTR|UBE2D3_ENST00000357194.6_Missense_Mutation_p.P27S|UBE2D3_ENST00000502404.1_5'UTR|UBE2D3_ENST00000504211.1_5'UTR|UBE2D3_ENST00000321805.7_Missense_Mutation_p.P25S|UBE2D3_ENST00000343106.5_Missense_Mutation_p.P25S|UBE2D3_ENST00000349311.8_Missense_Mutation_p.P25S|UBE2D3_ENST00000394801.4_Missense_Mutation_p.P25S|UBE2D3_ENST00000513098.1_5'UTR	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	25					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TCCCCAACTGGACCTGCAGAA	0.363000													16	93					0	0	0.00400662	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84605877	84605877	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:84605877T>A	ENST00000344803.2	+	4	539	c.492T>A	c.(490-492)tcT>tcA	p.S164S		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CTTCGGCTTCTGCGACTGAGT	0.572000													7	47					0	0	0.00198382	0	0
SEMA3C	10512	broad.mit.edu	37	7	80427413	80427413	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:80427413C>A	ENST00000265361.3	-	11	1687	c.1126G>T	c.(1126-1128)Gga>Tga	p.G376*	SEMA3C_ENST00000536800.1_Nonsense_Mutation_p.G228*|SEMA3C_ENST00000544525.1_Nonsense_Mutation_p.G394*|SEMA3C_ENST00000419255.2_Nonsense_Mutation_p.G376*	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	376	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTTACAGTTCCAGGGCGAGGA	0.388000													12	33					0.00316338	0.0094562	0.00316338	1	0
DNAH3	55567	broad.mit.edu	37	16	21048036	21048036	+	Splice_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:21048036C>A	ENST00000261383.3	-	35	5084	c.5085_splice	c.e35+1	p.Q1695_splice	DNAH3_ENST00000415178.1_Splice_Site_p.Q1695_splice	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1695	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGGAACCAACCTGGATAATTT	0.383000													18	55					2.94398e-08	1.19562e-07	0.000958276	1	0
RGS6	9628	broad.mit.edu	37	14	72939605	72939605	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:72939605G>A	ENST00000553530.1	+	9	769	c.562G>A	c.(562-564)Gaa>Aaa	p.E188K	RGS6_ENST00000554782.1_Missense_Mutation_p.E49K|RGS6_ENST00000402788.2_Missense_Mutation_p.E188K|RGS6_ENST00000343854.6_Missense_Mutation_p.E188K|RGS6_ENST00000404301.2_Missense_Mutation_p.E188K|RGS6_ENST00000406236.4_Missense_Mutation_p.E188K|RGS6_ENST00000355512.6_Missense_Mutation_p.E188K|RGS6_ENST00000553525.1_Missense_Mutation_p.E188K|RGS6_ENST00000553690.1_3'UTR|RGS6_ENST00000407322.4_Missense_Mutation_p.E188K|RGS6_ENST00000556437.1_Missense_Mutation_p.E188K|RGS6_ENST00000434263.2_Missense_Mutation_p.E119K|RGS6_ENST00000555571.1_Missense_Mutation_p.E188K	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	188					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGACAAGACAGAAAGGAAAAT	0.398000													68	154					0	0	0.00361006	0	0
ZXDB	158586	broad.mit.edu	37	X	57620764	57620764	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:57620764A>T	ENST00000374888.1	+	1	2496	c.2283A>T	c.(2281-2283)gtA>gtT	p.V761V		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	761					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						AGTGGAACGTACATCCTGACT	0.473000													11	83					0	0	0.000673444	0	0
SLA	6503	broad.mit.edu	37	8	134072432	134072432	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:134072432G>A	ENST00000395352.3	-	2	373	c.25C>T	c.(25-27)Cca>Tca	p.P9S	SLA_ENST00000524345.1_Intron|TG_ENST00000377869.1_Intron|SLA_ENST00000517648.1_Missense_Mutation_p.P9S|SLA_ENST00000518565.1_5'UTR|TG_ENST00000220616.4_Intron|SLA_ENST00000427060.2_Missense_Mutation_p.P32S|TG_ENST00000519543.1_Intron|TG_ENST00000542445.1_Intron|SLA_ENST00000338087.5_5'UTR	NM_001045557.2	NP_001039022.2	Q13239	SLAP1_HUMAN	Src-like-adaptor	0						endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			GGGGCCGCTGGTGATGCCCAG	0.577000													7	24					0	0	0.00198382	0	0
OR9A4	130075	broad.mit.edu	37	7	141619587	141619587	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:141619587G>C	ENST00000548136.1	+	1	971	c.912G>C	c.(910-912)ggG>ggC	p.G304G	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TTCGGGATGGGGTGAAACGCT	0.423000													12	57					0	0	0.00136819	0	0
WDR52	55779	broad.mit.edu	37	3	113082352	113082352	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:113082352C>A	ENST00000393845.2	-	20	2809	c.2743G>T	c.(2743-2745)Gaa>Taa	p.E915*	WDR52_ENST00000295868.2_Nonsense_Mutation_p.E915*	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	915										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						TCAATGTCTTCTGGAATTGGC	0.363000													8	45					0.00307968	0.00922579	0.00307968	1	0
GPR149	344758	broad.mit.edu	37	3	154145425	154145425	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:154145425G>T	ENST00000389740.2	-	2	1153	c.1054C>A	c.(1054-1056)Ctg>Atg	p.L352M		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	352						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GTGGCCAGCAGGGTAAGTAGA	0.532000													6	23					5.9392e-07	2.24818e-06	0.00116845	1	0
C9orf41	138199	broad.mit.edu	37	9	77598701	77598701	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:77598701C>T	ENST00000376834.3	-	8	1364	c.1212G>A	c.(1210-1212)gtG>gtA	p.V404V	RP11-197P3.4_ENST00000455609.1_RNA	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	404										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						GCTTACGGACCACAAACAAGA	0.348000													11	61					0	0	0.00136819	0	0
CCDC60	160777	broad.mit.edu	37	12	119937958	119937958	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:119937958C>G	ENST00000327554.2	+	6	1098	c.633C>G	c.(631-633)ttC>ttG	p.F211L	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	211										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GGGAGCATTTCATCACAGCGC	0.468000													13	48					0	0	0.00185496	0	0
BAI3	577	broad.mit.edu	37	6	69349230	69349230	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:69349230C>A	ENST00000370598.1	+	3	1484	c.663C>A	c.(661-663)ccC>ccA	p.P221P		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	221					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TGGTGTTACCCCTGAATGAGC	0.522000													12	20					3.07112e-06	1.10544e-05	0.000978159	1	0
PIEZO2	63895	broad.mit.edu	37	18	10681738	10681738	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:10681738T>A	ENST00000302079.6	-	46	7170	c.7171A>T	c.(7171-7173)Atg>Ttg	p.M2391L	PIEZO2_ENST00000538948.1_Missense_Mutation_p.M411L|PIEZO2_ENST00000285141.4_Missense_Mutation_p.M246L|PIEZO2_ENST00000503781.3_Missense_Mutation_p.M2454L|PIEZO2_ENST00000580640.1_Missense_Mutation_p.M2479L			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2423						integral to membrane	ion channel activity										TGGGCACTCATTGTGAAAATA	0.378000													16	71					0	0	0.00074312	0	0
TEX11	56159	broad.mit.edu	37	X	69774579	69774579	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:69774579C>A	ENST00000395889.2	-	27	2412	c.2257G>T	c.(2257-2259)Gat>Tat	p.D753Y	TEX11_ENST00000374333.2_Missense_Mutation_p.D738Y|TEX11_ENST00000344304.3_Missense_Mutation_p.D753Y|TEX11_ENST00000374320.2_Missense_Mutation_p.D428Y	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	753							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					AGTAATGGATCATTCAATTTG	0.363000													17	44					9.16793e-09	3.80087e-08	0.000566183	1	0
VMP1	81671	broad.mit.edu	37	17	57917132	57917132	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:57917132G>C	ENST00000262291.4	+	12	1391	c.1081G>C	c.(1081-1083)Gaa>Caa	p.E361Q	VMP1_ENST00000536180.1_Missense_Mutation_p.E264Q|VMP1_ENST00000545362.1_Missense_Mutation_p.E305Q|VMP1_ENST00000537567.1_Missense_Mutation_p.E227Q|VMP1_ENST00000539763.1_Missense_Mutation_p.E169Q|VMP1_ENST00000588617.1_3'UTR	NM_030938.3	NP_112200.2	Q96GC9	VMP1_HUMAN	vacuole membrane protein 1	361					autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|skin(2)	16						TCTACAGGGAGAAAACTGGTT	0.368000													20	299					0	0	0.00229938	0	0
CYLC2	1539	broad.mit.edu	37	9	105767379	105767379	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:105767379G>A	ENST00000374798.3	+	5	536	c.466G>A	c.(466-468)Gat>Aat	p.D156N	CYLC2_ENST00000487798.1_Missense_Mutation_p.D156N	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	156	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton	p.D156Y(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				agaaaagctagatgcaaagaa	0.353000													5	28					0	0	0.000602214	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801983	185801983	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185801983G>T	ENST00000302277.6	+	4	2454	c.1860G>T	c.(1858-1860)atG>atT	p.M620I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	620						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GCTGCAAAATGGAAGCAGAGA	0.338000													41	134					1.00776e-21	5.35803e-21	0.00361006	1	0
HOXD11	3237	broad.mit.edu	37	2	176973687	176973687	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:176973687C>A	ENST00000249504.5	+	2	904	c.834C>A	c.(832-834)atC>atA	p.I278I	HOXD10_ENST00000490088.2_3'UTR|HOXD11_ENST00000498438.1_3'UTR	NM_021192.2	NP_067015.2	P31277	HXD11_HUMAN	homeobox D11	278						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity							OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		AGTACCAGATCCGCGAACTGG	0.527000			T	NUP98	AML								10	65					3.07112e-06	1.10544e-05	0.000978159	1	0
OR2T1	26696	broad.mit.edu	37	1	248570293	248570293	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248570293C>A	ENST00000366474.1	+	1	998	c.998C>A	c.(997-999)cCc>cAc	p.P333H		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	333					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTCTCACACCCATGCTGAAC	0.522000													27	122					1.68575e-08	6.96812e-08	0.00127121	1	0
KMT2C	58508	broad.mit.edu	37	7	151856020	151856020	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:151856020C>G	ENST00000355193.2	-	44	11816	c.11598G>C	c.(11596-11598)aaG>aaC	p.K3866N	KMT2C_ENST00000262189.6_Missense_Mutation_p.K3866N					lysine (K)-specific methyltransferase 2C																		TTTTCCTTTTCTTTGAGCGAG	0.483000													16	149					0	0	0.00316338	0	0
SCN7A	6332	broad.mit.edu	37	2	167262212	167262212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:167262212G>A	ENST00000409855.1	-	25	5053	c.4927C>T	c.(4927-4929)Cga>Tga	p.R1643*		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1643					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTGTCATTTCGCCTCAAGCGG	0.368000													16	166					0	0	0.000566183	0	0
CDK5	1020	broad.mit.edu	37	7	150752397	150752397	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:150752397T>A	ENST00000485972.1	-	8	1228	c.547A>T	c.(547-549)Atc>Ttc	p.I183F	CDK5_ENST00000297518.4_Missense_Mutation_p.I151F	NM_004935.3	NP_004926.1	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5	183	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			central_nervous_system(1)|endometrium(2)|lung(5)|urinary_tract(1)	9		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CACATGTCGATGGACGTGGAG	0.582000													7	23					0	0	0.00448238	0	0
ZNF135	7694	broad.mit.edu	37	19	58578566	58578566	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:58578566A>G	ENST00000506786.1	+	5	1142	c.588A>G	c.(586-588)ggA>ggG	p.G196G	ZNF135_ENST00000439855.2_Silent_p.G238G|ZNF135_ENST00000359978.6_Silent_p.G250G|ZNF135_ENST00000511556.1_Silent_p.G250G|ZNF135_ENST00000313434.5_Silent_p.G238G|ZNF135_ENST00000401053.4_Silent_p.G262G			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	250					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CGCACACAGGAGAGAGACCTT	0.468000													19	117					0	0	0.00121646	0	0
IL15	3600	broad.mit.edu	37	4	142643115	142643115	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:142643115G>T	ENST00000477265.1	+	4	5076	c.68G>T	c.(67-69)tGg>tTg	p.W23L	IL15_ENST00000514653.1_Missense_Mutation_p.W23L|IL15_ENST00000296545.7_Missense_Mutation_p.W50L|IL15_ENST00000529613.1_Missense_Mutation_p.W50L|IL15_ENST00000320650.4_Missense_Mutation_p.W50L|IL15_ENST00000394159.1_Missense_Mutation_p.W23L			P40933	IL15_HUMAN	interleukin 15	50					cell-cell signaling|immune response|positive regulation of interleukin-17 production	endosome|extracellular space|Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	cytokine activity|cytokine receptor binding|signal transducer activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_hematologic(180;0.158)					GAAGCCAACTGGGTGAATGTA	0.353000													16	102					1.01871e-10	4.54829e-10	0.00121646	1	0
OR2T1	26696	broad.mit.edu	37	1	248570294	248570294	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248570294C>A	ENST00000366474.1	+	1	999	c.999C>A	c.(997-999)ccC>ccA	p.P333P		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	333					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCTCACACCCATGCTGAACC	0.527000													28	124					1.7881e-09	7.6172e-09	0.001512	1	0
PCSK4	54760	broad.mit.edu	37	19	1488005	1488005	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:1488005G>T	ENST00000300954.5	-	4	535	c.474C>A	c.(472-474)gaC>gaA	p.D158E	PCSK4_ENST00000587784.1_5'UTR	NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	158	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGCCATCGTCCAGCACAG	0.682000													15	62					4.14922e-12	1.98621e-11	0.00400662	1	0
RNLS	55328	broad.mit.edu	37	10	90074241	90074241	+	Silent	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:90074241T>C	ENST00000371947.3	-	6	2197	c.858A>G	c.(856-858)caA>caG	p.Q286Q	RNLS_ENST00000437752.1_Silent_p.Q203Q|RNLS_ENST00000331772.4_Silent_p.Q286Q	NM_018363.3	NP_060833.1	Q5VYX0	RNLS_HUMAN	renalase, FAD-dependent amine oxidase	286						extracellular region	oxidoreductase activity			breast(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7						GTCTCCATTTTTGGCATTTGG	0.418000													24	70					0	0	0.00106085	0	0
CYTIP	9595	broad.mit.edu	37	2	158300414	158300414	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:158300414C>A	ENST00000264192.3	-	1	240	c.119G>T	c.(118-120)aGa>aTa	p.R40I	CYTIP_ENST00000540637.1_Intron|CYTIP_ENST00000497432.1_Intron	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	40					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TTGAATCCTTCTATTATCGTC	0.502000													9	86					2.74318e-10	1.20544e-09	0.000442599	1	0
LRP1B	53353	broad.mit.edu	37	2	141200182	141200182	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:141200182G>T	ENST00000389484.3	-	66	11276	c.10305C>A	c.(10303-10305)agC>agA	p.S3435R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3435	LDL-receptor class A 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGAGAACAGCTGTTTTCAG	0.378000										TSP Lung(27;0.18)			22	72					4.26978e-12	2.03692e-11	0.00332997	1	0
ARHGAP24	83478	broad.mit.edu	37	4	86491875	86491875	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:86491875G>T	ENST00000395184.1	+	2	646		c.e2+1		ARHGAP24_ENST00000506421.1_Splice_Site|ARHGAP24_ENST00000503995.1_Splice_Site	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24						angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CAAGCCCTTGGTGAGTAGGAG	0.458000													12	55					9.05144e-12	4.27412e-11	0.00185496	1	0
KCNH8	131096	broad.mit.edu	37	3	19389436	19389436	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:19389436G>T	ENST00000328405.2	+	5	1056	c.790G>T	c.(790-792)Gtg>Ttg	p.V264L	KCNH8_ENST00000475063.1_3'UTR	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	264						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TGACATTGCAGTGGAGATTCT	0.403000													25	80					2.79863e-10	1.22594e-09	0.00465635	1	0
OR2L2	26246	broad.mit.edu	37	1	248202089	248202089	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248202089A>G	ENST00000366479.2	+	1	616	c.520A>G	c.(520-522)Aat>Gat	p.N174D	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAGAGCCATCAATCATTTTTT	0.428000													72	201					0	0	0.00361006	0	0
CNGB1	1258	broad.mit.edu	37	16	57954298	57954298	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:57954298G>T	ENST00000564448.1	-	19	1836	c.1776C>A	c.(1774-1776)ccC>ccA	p.P592P	CNGB1_ENST00000251102.8_Silent_p.P598P			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	598					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						CACAGGGCTTGGGGCTCTCCT	0.592000													4	35					0.00116845	0.00354607	0.00116845	1	0
REG1A	5967	broad.mit.edu	37	2	79350017	79350017	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79350017G>T	ENST00000233735.1	+	5	475	c.372G>T	c.(370-372)tgG>tgT	p.W124C		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	124	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						ACAAGTCCTGGGGCATTGGAG	0.552000													17	66					2.27731e-05	7.77521e-05	0.00188189	1	0
SP100	6672	broad.mit.edu	37	2	231371124	231371124	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:231371124A>T	ENST00000264052.5	+	22	2332	c.1977A>T	c.(1975-1977)atA>atT	p.I659I	SP100_ENST00000409112.1_Silent_p.I659I|SP100_ENST00000340126.4_Silent_p.I659I	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	659	SAND.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGCTAAGTATACGCTGCGGTG	0.448000													8	39					0	0	0.00307968	0	0
PI4K2B	55300	broad.mit.edu	37	4	25256887	25256887	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:25256887G>T	ENST00000264864.6	+	3	813	c.624_splice	c.e3+1	p.K208_splice	PI4K2B_ENST00000512921.1_Splice_Site_p.K112_splice	NM_018323.3	NP_060793.2	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	208	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|skin(3)	15		Breast(46;0.173)				CTAAAACAAAGGTAAGCCAGA	0.398000													12	26					0.000151284	0.000491234	0.00185496	1	0
MNDA	4332	broad.mit.edu	37	1	158813834	158813834	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:158813834C>A	ENST00000368141.4	+	4	753	c.492C>A	c.(490-492)gcC>gcA	p.A164A		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	164					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					CCTCAGGAGCCAGCACATCTG	0.488000													30	79					8.88839e-20	4.65471e-19	0.00209593	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433092	73433092	+	Silent	SNP	C	C	G	rs141774740		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:73433092C>G	ENST00000263666.4	-	10	2739	c.2625G>C	c.(2623-2625)gcG>gcC	p.A875A	PDZRN3_ENST00000479530.1_Silent_p.A592A|PDZRN3_ENST00000466780.1_Silent_p.A532A|PDZRN3_ENST00000535920.1_Silent_p.A597A|PDZRN3_ENST00000462146.2_Silent_p.A532A	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	875							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCTGGGCGTGCGCCGGGATGT	0.652000													6	30					0	0	0.00116845	0	0
SF3B3	23450	broad.mit.edu	37	16	70595659	70595659	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:70595659A>G	ENST00000302516.5	+	17	2471	c.2260A>G	c.(2260-2262)Att>Gtt	p.I754V		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	754					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				TCCCGAGGGCATTGTGGCCAT	0.527000													16	53					0	0	0.00400662	0	0
MUC16	94025	broad.mit.edu	37	19	9090346	9090346	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9090346G>T	ENST00000397910.4	-	1	1672	c.1469C>A	c.(1468-1470)tCt>tAt	p.S490Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	490	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGCCTCCCAGAGGTGCTGCC	0.537000													15	54					2.32078e-09	9.76693e-09	0.00316338	1	0
SLC8A2	6543	broad.mit.edu	37	19	47935674	47935674	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:47935674G>C	ENST00000236877.6	-	9	2534	c.2139C>G	c.(2137-2139)tcC>tcG	p.S713S	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000542837.1_Silent_p.S469S|SLC8A2_ENST00000539381.1_Silent_p.S176S	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	713					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GCTCCTCCCGGGACCCGTCCT	0.622000													6	35					0	0	0.00198382	0	0
BIRC8	112401	broad.mit.edu	37	19	53793483	53793483	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:53793483A>T	ENST00000426466.1	-	1	1392	c.145T>A	c.(145-147)Tgg>Agg	p.W49R		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	49					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		TTGGGCTTCCAGTTGGCTAGC	0.433000													11	45					0	0	0.000978159	0	0
NOL10	79954	broad.mit.edu	37	2	10712241	10712241	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:10712241C>A	ENST00000345985.3	-	20	1983	c.1873G>T	c.(1873-1875)Gga>Tga	p.G625*	NOL10_ENST00000381685.5_Nonsense_Mutation_p.G675*|NOL10_ENST00000542668.1_Nonsense_Mutation_p.G625*|NOL10_ENST00000538384.1_Nonsense_Mutation_p.G649*	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	675						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TTCAGGTGTCCGGCCGAACGA	0.478000													46	166					6.23363e-37	3.44581e-36	0.00361006	1	0
ASTN2	23245	broad.mit.edu	37	9	120053783	120053783	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:120053783C>A	ENST00000313400.4	-	2	552	c.452G>T	c.(451-453)gGc>gTc	p.G151V	ASTN2_ENST00000361209.2_Missense_Mutation_p.G151V|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.G151V			O75129	ASTN2_HUMAN	astrotactin 2	151						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGCTGCTGTGCCAGACATCTC	0.602000													5	29					0.000602214	0.00186834	0.000602214	1	0
TAF1L	138474	broad.mit.edu	37	9	32630111	32630111	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:32630111C>A	ENST00000242310.4	-	1	5556	c.5467G>T	c.(5467-5469)Ggg>Tgg	p.G1823W		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1823					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.G1823W(1)|p.G1823R(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTCCGTGCCCATCCTTGTGT	0.498000													6	31					0.00116845	0.00354607	0.00116845	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801970	185801970	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185801970C>G	ENST00000302277.6	+	4	2441	c.1847C>G	c.(1846-1848)aCt>aGt	p.T616S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	616						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAATCAGAAACTCGCTGCAAA	0.343000													31	129					0	0	0.00283554	0	0
CCDC66	285331	broad.mit.edu	37	3	56627033	56627033	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:56627033G>C	ENST00000394672.3	+	8	1042	c.972G>C	c.(970-972)gtG>gtC	p.V324V	CCDC66_ENST00000326595.7_Silent_p.V290V|CCDC66_ENST00000436465.2_Silent_p.V324V	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	324								p.V207V(1)|p.V324V(1)		breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TCAGTGCTGTGAAACAAGAAC	0.338000													17	118					0	0	0.000958276	0	0
NTRK3	4916	broad.mit.edu	37	15	88476310	88476310	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:88476310C>A	ENST00000394480.1	-	16	2143	c.1822G>T	c.(1822-1824)Ggc>Tgc	p.G608C	NTRK3_ENST00000542733.2_Missense_Mutation_p.G510C|NTRK3_ENST00000357724.2_Missense_Mutation_p.G600C|NTRK3_ENST00000360948.2_Missense_Mutation_p.G608C|NTRK3_ENST00000558676.1_Missense_Mutation_p.G600C|NTRK3_ENST00000355254.2_Missense_Mutation_p.G608C|NTRK3_ENST00000557856.1_Missense_Mutation_p.G600C	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	608	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G608S(2)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCCCCATCGCCGCACACTCCA	0.547000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			10	21					0.000442599	0.00138238	0.000442599	1	0
TRBV5-4	28611	broad.mit.edu	37	7	142168408	142168408	+	RNA	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:142168408C>G	ENST00000454561.2	-	0	515																											GATACAGGGCCGAGTCGTCCA	0.512000													9	65					0	0	0.000673444	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67320659	67320659	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:67320659T>C	ENST00000360461.5	+	16	5297	c.2762T>C	c.(2761-2763)cTc>cCc	p.L921P	PLEKHG4_ENST00000427155.2_Missense_Mutation_p.L921P|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.L921P|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.L840P	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	921	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CAGGTTAACCTCAAGGAACAG	0.602000													4	12					0	0	0.00024832	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482880	20482880	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:20482880G>C	ENST00000573854.1	+	6	877	c.763G>C	c.(763-765)Gat>Cat	p.D255H	ACSM2A_ENST00000575690.1_Missense_Mutation_p.D255H|ACSM2A_ENST00000396104.2_Missense_Mutation_p.D255H|ACSM2A_ENST00000417235.2_Missense_Mutation_p.D176H|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.D255H|ACSM2A_ENST00000536134.1_Missense_Mutation_p.D27H	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	255					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCAAGCCTCTGATATAATGTG	0.458000													22	118					0	0	0.0024448	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667841	70667841	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:70667841A>C	ENST00000260126.3	-	4	1782	c.1076T>G	c.(1075-1077)tTt>tGt	p.F359C	SLCO5A1_ENST00000530307.1_Missense_Mutation_p.F359C|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.F359C	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	359						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TATCACAAGAAACATTGCAAT	0.343000													7	44					0	0	0.000673444	0	0
PNISR	25957	broad.mit.edu	37	6	99854038	99854038	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:99854038C>G	ENST00000369239.5	-	8	1075	c.871G>C	c.(871-873)Gat>Cat	p.D291H	PNISR_ENST00000438806.1_Missense_Mutation_p.D291H	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	291						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TCTTCCTCATCACTATCCTAT	0.373000													14	26					0	0	0.00244969	0	0
RFC4	5984	broad.mit.edu	37	3	186510311	186510311	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:186510311C>T	ENST00000392481.2	-	7	924	c.643G>A	c.(643-645)Gcc>Acc	p.A215T	RFC4_ENST00000433496.1_Missense_Mutation_p.A215T|RFC4_ENST00000296273.2_Missense_Mutation_p.A215T	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	215					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TCCTTCTTGGCAATGTCTAGT	0.353000													30	111					0	0	0.00106085	0	0
FAM47A	158724	broad.mit.edu	37	X	34149860	34149860	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:34149860G>T	ENST00000346193.3	-	1	587	c.536C>A	c.(535-537)cCt>cAt	p.P179H		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	179	Pro-rich.									NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						ATGTTTACCAGGCTCAGTGGG	0.577000													5	24					1.6384e-10	7.24537e-10	0.00198382	1	0
IFNL2	282616	broad.mit.edu	37	19	39760264	39760264	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:39760264A>T	ENST00000331982.5	+	4	462	c.407A>T	c.(406-408)cAg>cTg	p.Q136L		NM_172138.1	NP_742150.1			interferon, lambda 2																		ATCCTCTCCCAGTTCCGGGCC	0.657000													6	40					0	0	0.00307968	0	0
OR2L3	391192	broad.mit.edu	37	1	248224827	248224827	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248224827C>A	ENST00000359959.3	+	1	844	c.844C>A	c.(844-846)Cca>Aca	p.P282T	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACCCTCACTCCAATGCTCAA	0.488000													21	63					5.45024e-15	2.74086e-14	0.00332997	1	0
ANKRD16	54522	broad.mit.edu	37	10	5927686	5927686	+	Splice_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:5927686C>A	ENST00000380094.5	-	3	1121	c.578_splice	c.e3+1	p.R193_splice	ANKRD16_ENST00000380092.4_Splice_Site_p.R193_splice|ANKRD16_ENST00000191063.8_Splice_Site_p.R193_splice	NM_019046.2	NP_061919.1	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16	193										breast(1)|endometrium(1)|large_intestine(5)|lung(3)|stomach(2)	12						ttgttcttacctcttaaGAAG	0.383000													7	30					5.18039e-06	1.85033e-05	0.00307968	1	0
GLYAT	10249	broad.mit.edu	37	11	58478071	58478071	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:58478071G>T	ENST00000344743.3	-	5	621	c.480C>A	c.(478-480)ccC>ccA	p.P160P	GLYAT_ENST00000529732.1_Silent_p.P160P|GLYAT_ENST00000278400.3_Silent_p.P160P	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	160					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	ACATGGCCTTGGGTTTGCCAC	0.443000													12	83					8.00594e-06	2.80914e-05	0.000958276	1	0
FBXL17	64839	broad.mit.edu	37	5	107559923	107559923	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:107559923C>A	ENST00000542267.1	-	5	1919	c.1513G>T	c.(1513-1515)Gat>Tat	p.D505Y	FBXL17_ENST00000359660.5_Missense_Mutation_p.D107Y|FBXL17_ENST00000496714.1_Missense_Mutation_p.D107Y	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	505										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		ACTGACTGATCTGTCACCTAG	0.433000													16	28					2.32078e-09	9.76693e-09	0.00316338	1	0
LGI1	9211	broad.mit.edu	37	10	95518028	95518028	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:95518028C>A	ENST00000371418.4	+	1	387	c.127C>A	c.(127-129)Cct>Act	p.P43T	LGI1_ENST00000542308.1_Missense_Mutation_p.P43T|LGI1_ENST00000371413.3_Missense_Mutation_p.P43T|LGI1_ENST00000478763.1_3'UTR	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	43	LRRNT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				GCCAAAATGCCCTGCCGTGTG	0.463000													16	98					1.02788e-11	4.8373e-11	0.000566183	1	0
CACNA1C	775	broad.mit.edu	37	12	2791158	2791158	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:2791158G>T	ENST00000399617.1	+	43	5487	c.5487G>T	c.(5485-5487)agG>agT	p.R1829S	CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000402845.3_Intron|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000347598.4_Intron|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399644.1_Intron|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R1829S|CACNA1C_ENST00000399597.1_Intron|CACNA1C_ENST00000399638.1_Intron	NM_001167624.1	NP_001161096.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1877					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGCTCAGGAGGGATTCAGGCT	0.572000													6	47					5.9392e-07	2.24818e-06	0.00116845	1	0
IL22RA1	58985	broad.mit.edu	37	1	24454646	24454646	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:24454646C>A	ENST00000270800.1	-	5	693	c.655G>T	c.(655-657)Gtg>Ttg	p.V219L		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	219	Fibronectin type-III 2.					integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGTGTCTTCACTCGGCACATG	0.547000													4	23					0.00024832	0.000791556	0.00024832	1	0
BAGE2	85319	broad.mit.edu	37	21	11039103	11039103	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:11039103G>T	ENST00000470054.1	-	0	1100									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTCCTTGTAGCCTTTCTATA	0.398000													21	454					2.89027e-11	1.32005e-10	0.00229938	1	0
HFM1	164045	broad.mit.edu	37	1	91739299	91739299	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:91739299T>C	ENST00000370425.3	-	34	3840	c.3742A>G	c.(3742-3744)Aga>Gga	p.R1248G	HFM1_ENST00000294696.5_Missense_Mutation_p.R480G|HFM1_ENST00000370424.3_Missense_Mutation_p.R927G|HFM1_ENST00000462405.1_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	1248							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GGTTCTTGTCTAACTTTTCCA	0.318000													16	60					0	0	0.000958276	0	0
RP1L1	94137	broad.mit.edu	37	8	10467395	10467395	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:10467395C>T	ENST00000382483.3	-	4	4436	c.4213G>A	c.(4213-4215)Gtc>Atc	p.V1405I		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1405					intracellular signal transduction			p.V1405I(1)		breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGCCCGTGGACGCTTCCTTCT	0.562000													64	211					0	0	0.00361006	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836075	12836075	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:12836075T>A	ENST00000357726.4	+	2	704	c.677T>A	c.(676-678)cTg>cAg	p.L226Q		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	226										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCTTACCTGGGCCAGATG	0.522000													28	85					0	0	0.000878237	0	0
RANBP3L	202151	broad.mit.edu	37	5	36270074	36270074	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:36270074G>T	ENST00000296604.3	-	3	654	c.169C>A	c.(169-171)Ctg>Atg	p.L57M	RANBP3L_ENST00000502994.1_Missense_Mutation_p.L57M|RANBP3L_ENST00000515759.1_Missense_Mutation_p.L57M	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	57					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GCTTCATACAGGGTGTCTTCT	0.388000													69	183					4.20717e-43	2.3349e-42	0.00361006	1	0
SKP2	6502	broad.mit.edu	37	5	36171762	36171762	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:36171762G>T	ENST00000274255.6	+	7	1024	c.828G>T	c.(826-828)gtG>gtT	p.V276V	SKP2_ENST00000274254.5_Silent_p.V276V|SKP2_ENST00000546211.1_Silent_p.V62V|SKP2_ENST00000508514.1_Intron	NM_005983.3	NP_005974.2	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	276					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			breast(1)|central_nervous_system(2)|ovary(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATGTACAGGTGGCTGTTGCGC	0.458000													83	141					4.47867e-22	2.39034e-21	0.00361006	1	0
OR6V1	346517	broad.mit.edu	37	7	142749748	142749748	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:142749748C>A	ENST00000418316.1	+	1	332	c.311C>A	c.(310-312)tCc>tAc	p.S104Y		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TTCCACTTTTCCCTGGGGTCC	0.562000													14	73					1.36491e-13	6.74227e-13	0.00185496	1	0
OR10A7	121364	broad.mit.edu	37	12	55615378	55615378	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:55615378G>A	ENST00000326258.1	+	1	570	c.570G>A	c.(568-570)gtG>gtA	p.V190V		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TAGTCACAGTGGATACAACCA	0.448000													15	57					0	0	0.00244969	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839603	128839603	+	Silent	SNP	G	G	T	rs79505038	by1000genomes	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:128839603G>T	ENST00000310343.9	-	22	5462	c.5463C>A	c.(5461-5463)ccC>ccA	p.P1821P	ARHGAP32_ENST00000392657.3_Silent_p.P1472P|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Silent_p.P1472P	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1821	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding	p.P1472P(1)|p.P1821P(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CCTCTCCCTCGGGACTGATGG	0.577000													5	46					0.00116845	0.00354607	0.00116845	1	0
SCN3A	6328	broad.mit.edu	37	2	165947492	165947492	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:165947492G>T	ENST00000360093.3	-	28	5662	c.5171C>A	c.(5170-5172)cCc>cAc	p.P1724H	SCN3A_ENST00000540861.1_Missense_Mutation_p.P207H|SCN3A_ENST00000409101.3_Missense_Mutation_p.P1675H|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000283254.7_Missense_Mutation_p.P1724H	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1724						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GTCACAGTCGGGTGGTGCACT	0.458000													25	115					4.87955e-14	2.43628e-13	0.000878237	1	0
CACNA1E	777	broad.mit.edu	37	1	181452918	181452918	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:181452918G>T	ENST00000526775.1	+	1	203	c.38G>T	c.(37-39)gGg>gTg	p.G13V	CACNA1E_ENST00000367573.2_Missense_Mutation_p.G13V|CACNA1E_ENST00000367570.1_Missense_Mutation_p.G13V|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G13V|CACNA1E_ENST00000357570.5_5'UTR|CACNA1E_ENST00000358338.5_5'UTR|CACNA1E_ENST00000367567.4_5'UTR	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	13					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCCAGGCCAGGGTCCGGCGAT	0.652000													11	22					1.36491e-13	6.74227e-13	0.00185496	1	0
IGKV3D-11	28876	broad.mit.edu	37	2	90211751	90211751	+	RNA	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:90211751A>G	ENST00000390277.2	+	0	109																											TGGAAGCCCCAGCGCAGCTTC	0.572000													7	51					0	0	0.000978159	0	0
GTPBP10	85865	broad.mit.edu	37	7	90014350	90014350	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:90014350A>T	ENST00000222511.6	+	10	1112	c.1046A>T	c.(1045-1047)cAg>cTg	p.Q349L	GTPBP10_ENST00000257659.8_Missense_Mutation_p.Q270L	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	349					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						CAGGCCAACCAGGAAAATGAT	0.388000													26	121					0	0	0.000878237	0	0
BRWD3	254065	broad.mit.edu	37	X	79978262	79978262	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:79978262T>A	ENST00000373275.4	-	17	1891	c.1675A>T	c.(1675-1677)Acg>Tcg	p.T559S		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	559										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CGATAATCCGTGTGGAAGAAC	0.388000													26	68					0	0	0.00127121	0	0
PSAP	5660	broad.mit.edu	37	10	73591639	73591639	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:73591639G>A	ENST00000394936.3	-	3	360	c.213C>T	c.(211-213)acC>acT	p.T71T	PSAP_ENST00000394934.1_Silent_p.T71T			P07602	SAP_HUMAN	prosaposin	71	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						CACCAGCTGCGGTGACAACGT	0.517000													29	95					0	0	0.0024448	0	0
ACVR1C	130399	broad.mit.edu	37	2	158401076	158401076	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:158401076T>C	ENST00000243349.7	-	5	1184	c.824A>G	c.(823-825)cAg>cGg	p.Q275R	ACVR1C_ENST00000348328.5_Missense_Mutation_p.Q118R|ACVR1C_ENST00000335450.7_Missense_Mutation_p.Q195R|ACVR1C_ENST00000409680.3_Missense_Mutation_p.Q225R	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	275	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TAAGGAGCCCTGTTCATGATA	0.383000													13	69					0	0	0.00136819	0	0
FLG	2312	broad.mit.edu	37	1	152280118	152280118	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152280118A>T	ENST00000368799.1	-	3	7279	c.7244T>A	c.(7243-7245)cTc>cAc	p.L2415H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2415	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCTGGTAGAGGAAAGACCC	0.612000									Ichthyosis				27	143					0	0	0.00209593	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615563	140615563	+	RNA	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:140615563C>A	ENST00000526308.1	+	0	1626					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						CAGACAGAGACTCAGGCACCA	0.652000													35	87					5.91797e-21	3.1345e-20	0.0024448	1	0
ARPP21	10777	broad.mit.edu	37	3	35835431	35835431	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:35835431G>T	ENST00000187397.4	+	20	2876	c.2420G>T	c.(2419-2421)gGt>gTt	p.G807V	ARPP21_ENST00000417925.1_Missense_Mutation_p.G808V|ARPP21_ENST00000444190.1_Missense_Mutation_p.G788V|ARPP21_ENST00000337271.5_Missense_Mutation_p.G788V|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000458225.1_Missense_Mutation_p.G808V	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	807						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						AGCAATGCTGGTTGGCAGGTC	0.498000													7	12					0.00198382	0.00598151	0.00198382	1	0
PARP4	143	broad.mit.edu	37	13	25021220	25021220	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:25021220G>A	ENST00000381989.3	-	26	3324	c.3219C>T	c.(3217-3219)gcC>gcT	p.A1073A		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1073					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ACGGCACCTGGGCTGGGGCCT	0.512000													6	69					0	0	0.00198382	0	0
CPZ	8532	broad.mit.edu	37	4	8607877	8607877	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:8607877A>G	ENST00000382480.2	+	5	1260	c.460A>G	c.(460-462)Atg>Gtg	p.M154V	CPZ_ENST00000360986.4_Missense_Mutation_p.M291V|CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000315782.6_Missense_Mutation_p.M280V	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	291	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GCTGCCCTCCATGAACCCTGA	0.617000													3	12					0	0	0.00024832	0	0
AGTR1	185	broad.mit.edu	37	3	148459034	148459034	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:148459034C>A	ENST00000542281.1	+	4	658	c.212C>A	c.(211-213)gCa>gAa	p.A71E	AGTR1_ENST00000497524.1_Missense_Mutation_p.A71E|AGTR1_ENST00000349243.3_Missense_Mutation_p.A71E|AGTR1_ENST00000402260.1_Missense_Mutation_p.A71E|AGTR1_ENST00000404754.2_Missense_Mutation_p.A71E|AGTR1_ENST00000461609.1_Missense_Mutation_p.A71E|AGTR1_ENST00000474935.1_Missense_Mutation_p.A71E|AGTR1_ENST00000418473.2_Missense_Mutation_p.A71E|AGTR1_ENST00000475347.1_Missense_Mutation_p.A71E	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	71					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TTGAATTTAGCACTGGCTGAC	0.408000													14	48					2.61681e-11	1.19909e-10	0.00244969	1	0
CNGA2	1260	broad.mit.edu	37	X	150911608	150911608	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:150911608G>A	ENST00000329903.4	+	6	666	c.633G>A	c.(631-633)ctG>ctA	p.L211L		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	211					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					CCAAGAAACTGCGAGACAACT	0.493000													10	34					0	0	0.000673444	0	0
ULK2	9706	broad.mit.edu	37	17	19687150	19687150	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:19687150C>A	ENST00000395544.4	-	22	2819	c.2320G>T	c.(2320-2322)Ggc>Tgc	p.G774C	ULK2_ENST00000361658.2_Missense_Mutation_p.G774C	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	774					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					AAGCCTGGGCCAGGCGGGGAC	0.642000													7	20					2.0095e-06	7.30869e-06	0.00198382	1	0
IGKV3D-11	28876	broad.mit.edu	37	2	90211750	90211750	+	RNA	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:90211750C>A	ENST00000390277.2	+	0	108																											ATGGAAGCCCCAGCGCAGCTT	0.572000													8	50					5.50884e-06	1.93783e-05	0.00136819	1	0
TBX22	50945	broad.mit.edu	37	X	79279561	79279561	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:79279561G>T	ENST00000442340.1	+	4	486		c.e4-1		TBX22_ENST00000373296.3_Splice_Site|TBX22_ENST00000373291.1_Splice_Site|TBX22_ENST00000373294.5_Splice_Site	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22						multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CTTTCTTACAGGCGGATGTTC	0.483000													7	61					8.12818e-05	0.000265788	0.00198382	1	0
DDX60	55601	broad.mit.edu	37	4	169158497	169158497	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:169158497C>A	ENST00000393743.3	-	32	4642	c.4351G>T	c.(4351-4353)Gtt>Ttt	p.V1451F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1451							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CTGACAAAAACAAGATTAGAA	0.353000													11	34					1.58986e-06	5.82811e-06	0.000673444	1	0
TRIM42	287015	broad.mit.edu	37	3	140409921	140409921	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:140409921G>A	ENST00000286349.3	+	4	2163	c.1972G>A	c.(1972-1974)Gac>Aac	p.D658N		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	658	Fibronectin type-III.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ACAAATTCGGGACATAATGCA	0.443000													14	97					0	0	0.00185496	0	0
MUC16	94025	broad.mit.edu	37	19	9028337	9028337	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9028337G>T	ENST00000397910.4	-	11	36658	c.36455C>A	c.(36454-36456)cCt>cAt	p.P12152H		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12154	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGTCTTCAGGGTCAGGGCG	0.572000													23	81					4.16121e-05	0.000140014	0.00278032	1	0
EXPH5	23086	broad.mit.edu	37	11	108384345	108384345	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:108384345G>A	ENST00000265843.4	-	6	1999	c.1889C>T	c.(1888-1890)tCc>tTc	p.S630F	EXPH5_ENST00000525344.1_Missense_Mutation_p.S623F|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000428840.1_Missense_Mutation_p.S554F|EXPH5_ENST00000443411.1_Missense_Mutation_p.S442F	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	630					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTGGGAAAAGGAAGTTTTGAA	0.408000													8	115					0	0	0.000442599	0	0
SLC36A1	206358	broad.mit.edu	37	5	150858985	150858985	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:150858985G>T	ENST00000243389.3	+	10	1317	c.1094G>T	c.(1093-1095)cGa>cTa	p.R365L	SLC36A1_ENST00000521925.1_Missense_Mutation_p.R365L|SLC36A1_ENST00000520701.1_Missense_Mutation_p.R365L	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	365					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TTTGTGTCCCGAGCGCCCGAG	0.507000													9	40					1.58986e-06	5.82811e-06	0.000673444	1	0
EPSTI1	94240	broad.mit.edu	37	13	43474446	43474446	+	Splice_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:43474446C>A	ENST00000313640.7	-	10	912	c.848_splice	c.e10+1	p.R283_splice	EPSTI1_ENST00000398762.3_Splice_Site_p.R283_splice|EPSTI1_ENST00000313624.7_Splice_Site_p.R272_splice	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	283										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		CCAGTTTTACCTCCTGTGTTC	0.343000													12	43					4.3838e-07	1.68227e-06	0.00185496	1	0
MAP4K1	11184	broad.mit.edu	37	19	39103262	39103262	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:39103262C>G	ENST00000591517.1	-	9	682	c.654G>C	c.(652-654)gtG>gtC	p.V218V	MAP4K1_ENST00000396857.2_Silent_p.V218V|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000586296.1_Silent_p.V218V|MAP4K1_ENST00000589130.1_Silent_p.V214V|MAP4K1_ENST00000423454.2_5'UTR	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	218	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGAGAGGGTGCACATCAAAGA	0.622000													6	24					0	0	0.00116845	0	0
FAM74A3	728495	broad.mit.edu	37	9	40716103	40716103	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:40716103G>T	ENST00000604146.1	+	0	442					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AAACAGCTCAGACGCTGTCTG	0.532000													6	55					3.59834e-05	0.000121368	0.00116845	1	0
OR5C1	392391	broad.mit.edu	37	9	125552135	125552135	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:125552135C>A	ENST00000373680.2	+	1	986	c.924C>A	c.(922-924)acC>acA	p.T308T		NM_001001923.1	NP_001001923.1	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(5)|skin(1)	20						TCAGGCAGACCTGGAGCCGAT	0.582000													8	39					0.000274275	0.00086833	0.00448238	1	0
RGPD3	653489	broad.mit.edu	37	2	107040375	107040375	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:107040375C>T	ENST00000409886.3	-	20	4135	c.4048G>A	c.(4048-4050)Ggt>Agt	p.G1350S	RGPD3_ENST00000304514.7_Missense_Mutation_p.G1350S	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1350	RanBD1 2.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTTCCTCACCACTGGATACT	0.383000													22	261					0	0	0.00106085	0	0
KRT6B	3854	broad.mit.edu	37	12	52845722	52845722	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:52845722C>A	ENST00000252252.3	-	1	188	c.141G>T	c.(139-141)ctG>ctT	p.L47L		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	47	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		ATGCGCCACCCAGGCCACCAC	0.667000													8	68					1.08611e-07	4.24985e-07	0.000978159	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77401440	77401440	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:77401440C>A	ENST00000282849.5	-	4	1094	c.676G>T	c.(676-678)Ggt>Tgt	p.G226C	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	226					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GGGGAGTAACCAGGATAATTC	0.537000													11	30					0.00010058	0.000328121	0.00136819	1	0
TTN	7273	broad.mit.edu	37	2	179416521	179416521	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179416521A>T	ENST00000589042.1	-	335	91330	c.91106T>A	c.(91105-91107)aTc>aAc	p.I30369N	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I21304N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I21429N|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.I28728N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.I27801N|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I21496N|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28728							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCCAGAGGATGCTATTTCT	0.408000													13	127					0	0	0.00185496	0	0
SACS	26278	broad.mit.edu	37	13	23904603	23904603	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:23904603T>A	ENST00000382298.3	-	10	14000	c.13412A>T	c.(13411-13413)gAg>gTg	p.E4471V	SACS_ENST00000382292.3_Missense_Mutation_p.E4471V|SACS_ENST00000402364.1_Missense_Mutation_p.E3721V	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4471	HEPN.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCACACCCACTCATTGGCATT	0.443000													35	125					0	0	0.000953801	0	0
RYR3	6263	broad.mit.edu	37	15	33878289	33878289	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:33878289T>A	ENST00000389232.4	+	16	1830	c.1760T>A	c.(1759-1761)cTg>cAg	p.L587Q	RYR3_ENST00000415757.3_Missense_Mutation_p.L587Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	587	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCATCTCCCTGTTGGATAAG	0.463000													9	27					0	0	0.000673444	0	0
MC5R	4161	broad.mit.edu	37	18	13826290	13826290	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:13826290G>T	ENST00000324750.3	+	1	748	c.526G>T	c.(526-528)Gtc>Ttc	p.V176F		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	176					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						CTGCGGCATTGTCTTCATCCT	0.557000													69	202					5.98616e-33	3.29594e-32	0.00361006	1	0
MUC17	140453	broad.mit.edu	37	7	100682907	100682907	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:100682907A>T	ENST00000306151.4	+	3	8274	c.8210A>T	c.(8209-8211)gAa>gTa	p.E2737V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2737	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTGCTGAAGGTACCAGC	0.502000													60	296					0	0	0.00361006	0	0
NFKBIA	4792	broad.mit.edu	37	14	35873698	35873698	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:35873698C>T	ENST00000216797.5	-	1	254	c.153G>A	c.(151-153)gaG>gaA	p.E51E	NFKBIA_ENST00000557100.1_5'UTR|NFKBIA_ENST00000557140.1_Silent_p.E51E	NM_020529.2	NP_065390.1	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	51					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(3)|endometrium(1)|large_intestine(2)|liver(1)	7	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		CGAGGCGGATCTCCTGCAGCT	0.677000													5	11					0	0	0.00116845	0	0
GPR27	2850	broad.mit.edu	37	3	71804195	71804195	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:71804195G>T	ENST00000304411.2	+	1	995	c.995G>T	c.(994-996)gGc>gTc	p.G332V		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	332						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		GCGCAGGCCGGCATCAACCCC	0.706000													4	8					0.00024832	0.000791556	0.00024832	1	0
RELN	5649	broad.mit.edu	37	7	103290776	103290776	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:103290776C>A	ENST00000428762.1	-	16	2106	c.1947G>T	c.(1945-1947)agG>agT	p.R649S	RELN_ENST00000343529.5_Missense_Mutation_p.R649S|RELN_ENST00000424685.2_Missense_Mutation_p.R649S	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	649					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCAGCGAATCCTGGTGTTCC	0.423000													20	51					1.50039e-11	6.99011e-11	0.00188189	1	0
MED13L	23389	broad.mit.edu	37	12	116413011	116413011	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:116413011C>A	ENST00000281928.3	-	25	5902	c.5696G>T	c.(5695-5697)gGg>gTg	p.G1899V		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1899					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent			p.G1899V(1)		NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCCAAGTCGCCCGATTACAAC	0.443000													9	62					7.48243e-07	2.80944e-06	0.000442599	1	0
INSIG2	51141	broad.mit.edu	37	2	118864760	118864760	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:118864760G>A	ENST00000245787.4	+	5	837	c.631G>A	c.(631-633)Gca>Aca	p.A211T	INSIG2_ENST00000485520.1_3'UTR	NM_016133.2	NP_057217.2	Q9Y5U4	INSI2_HUMAN	insulin induced gene 2	211					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						TCGACAACTGGCAATGGTAAG	0.378000													8	106					0	0	0.00307968	0	0
ZNF521	25925	broad.mit.edu	37	18	22806665	22806665	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:22806665C>A	ENST00000361524.3	-	4	1365	c.1217G>T	c.(1216-1218)aGc>aTc	p.S406I	ZNF521_ENST00000538137.2_Missense_Mutation_p.S406I|ZNF521_ENST00000584787.1_Missense_Mutation_p.S186I	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	406					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GTAAATACAGCTGTAGGTAAC	0.463000			T	PAX5	ALL								26	50					3.73988e-18	1.9295e-17	0.00106085	1	0
TRPM6	140803	broad.mit.edu	37	9	77357520	77357520	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:77357520C>A	ENST00000451710.3	-	32	5406	c.5169G>T	c.(5167-5169)atG>atT	p.M1723I	TRPM6_ENST00000449912.2_Missense_Mutation_p.M1714I|TRPM6_ENST00000376864.4_Missense_Mutation_p.M1723I|TRPM6_ENST00000376871.3_Missense_Mutation_p.M556I|TRPM6_ENST00000376872.3_Missense_Mutation_p.M674I|TRPM6_ENST00000361255.3_Missense_Mutation_p.M1714I|TRPM6_ENST00000360774.1_Missense_Mutation_p.M1719I			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1719					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GAGAAAGCCTCATTAAATTAT	0.373000													10	39					2.27111e-07	8.78794e-07	0.00136819	1	0
MYO6	4646	broad.mit.edu	37	6	76599837	76599837	+	Nonsense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:76599837G>T	ENST00000369981.3	+	26	3001	c.2722G>T	c.(2722-2724)Gaa>Taa	p.E908*	MYO6_ENST00000369985.4_Nonsense_Mutation_p.E908*|MYO6_ENST00000369977.3_Nonsense_Mutation_p.E908*|MYO6_ENST00000369975.1_Nonsense_Mutation_p.E908*			Q9UM54	MYO6_HUMAN	myosin VI	908					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAGCTCAGAGGAACTCCTCAG	0.368000													21	66					6.21321e-17	3.17033e-16	0.00278032	1	0
TSHZ3	57616	broad.mit.edu	37	19	31770099	31770099	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:31770099G>T	ENST00000240587.4	-	2	927	c.600C>A	c.(598-600)agC>agA	p.S200R		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	200					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGAGCTTGCTGCTCTGCCGGT	0.627000													9	34					1.08611e-07	4.24985e-07	0.000978159	1	0
OR11H1	81061	broad.mit.edu	37	22	16449081	16449081	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:16449081C>A	ENST00000252835.4	-	1	724	c.724G>T	c.(724-726)Ggt>Tgt	p.G242C		NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		GAAGGCATACCCAACATAGCT	0.408000													49	166					3.10996e-30	1.70558e-29	0.00361006	1	0
OR2T6	254879	broad.mit.edu	37	1	248551233	248551233	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248551233G>T	ENST00000355728.2	+	1	324	c.324G>T	c.(322-324)atG>atT	p.M108I		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGGCTTTATGGGGGCTGAAT	0.562000													12	67					6.40141e-05	0.00021282	0.000978159	1	0
CA10	56934	broad.mit.edu	37	17	50008437	50008437	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:50008437T>A	ENST00000451037.2	-	3	1132	c.192A>T	c.(190-192)aaA>aaT	p.K64N	CA10_ENST00000442502.2_Missense_Mutation_p.K64N|CA10_ENST00000285273.4_Missense_Mutation_p.K64N|CA10_ENST00000570565.1_5'UTR|CA10_ENST00000340813.6_Missense_Mutation_p.K70N	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	64					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GCGACTGCCGTTTCCCCACAG	0.478000													18	107					0	0	0.000958276	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14787073	14787073	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:14787073G>T	ENST00000358984.4	+	15	1888	c.1708G>T	c.(1708-1710)Gat>Tat	p.D570Y	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Missense_Mutation_p.D570Y	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	570										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACAAAAGGACGATGAAGAAAA	0.289000													12	47					4.3838e-07	1.68227e-06	0.00185496	1	0
OR4A16	81327	broad.mit.edu	37	11	55110821	55110821	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55110821G>T	ENST00000314721.2	+	1	195	c.145G>T	c.(145-147)Ggc>Tgc	p.G49C		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GACTACTATTGGCAGCCCCTC	0.413000													19	87					2.94398e-08	1.19562e-07	0.000958276	1	0
OR13C4	138804	broad.mit.edu	37	9	107289036	107289036	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:107289036C>A	ENST00000277216.3	-	1	454	c.455G>T	c.(454-456)gGt>gTt	p.G152V		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ATTGATTCCACCAGAAAGCCA	0.423000													18	99					3.32936e-07	1.28471e-06	0.00074312	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655024	31655024	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:31655024C>A	ENST00000340345.4	-	1	252	c.227G>T	c.(226-228)tGt>tTt	p.C76F		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	76						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						CTTGGGCTCACAGCTGGGAGA	0.527000													13	49					1.49906e-05	5.13069e-05	0.00244969	1	0
PCED1A	64773	broad.mit.edu	37	20	2819111	2819111	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:2819111G>A	ENST00000360652.2	-	6	1110	c.608C>T	c.(607-609)gCa>gTa	p.A203V	PCED1A_ENST00000356872.3_Missense_Mutation_p.A152V	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		CAGGGAGCCTGCCAGGGGCTG	0.572000													5	33					0	0	0.00198382	0	0
PTPRO	5800	broad.mit.edu	37	12	15669861	15669861	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:15669861G>T	ENST00000281171.4	+	9	2080	c.1750G>T	c.(1750-1752)Gca>Tca	p.A584S	PTPRO_ENST00000348962.2_Missense_Mutation_p.A584S|PTPRO_ENST00000543886.1_Missense_Mutation_p.A584S	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	584	Fibronectin type-III 6.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				CTATGAAATAGCAGCAACTGT	0.413000													33	110					1.32136e-16	6.71769e-16	0.00195071	1	0
ABHD13	84945	broad.mit.edu	37	13	108881821	108881821	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:108881821A>G	ENST00000375898.3	+	2	556	c.255A>G	c.(253-255)ccA>ccG	p.P85P		NM_032859.2	NP_116248.2	Q7L211	ABHDD_HUMAN	abhydrolase domain containing 13	85						integral to membrane	hydrolase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTGGCATTCCACATGAAAACA	0.378000													22	133					0	0	0.00332997	0	0
RUNX1T1	862	broad.mit.edu	37	8	92998434	92998434	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:92998434G>T	ENST00000523629.1	-	9	1651	c.1197C>A	c.(1195-1197)gcC>gcA	p.A399A	RUNX1T1_ENST00000518844.1_Silent_p.A372A|RUNX1T1_ENST00000436581.2_Silent_p.A410A|RUNX1T1_ENST00000396218.1_Silent_p.A372A|RUNX1T1_ENST00000422361.2_Silent_p.A362A|RUNX1T1_ENST00000360348.2_Silent_p.A362A|RUNX1T1_ENST00000265814.3_Silent_p.A399A|RUNX1T1_ENST00000520724.1_Silent_p.A362A	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	399					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTAAGTCCTCGGCGTCACTGT	0.512000													49	90					3.86236e-30	2.10991e-29	0.00361006	1	0
SLC5A5	6528	broad.mit.edu	37	19	17986910	17986910	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:17986910C>A	ENST00000222248.3	+	5	1040	c.693C>A	c.(691-693)ctC>ctA	p.L231L		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	231					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						GGATCAACCTCATGGAGTGAG	0.622000													13	35					5.50884e-06	1.93783e-05	0.00136819	1	0
KLF7	8609	broad.mit.edu	37	2	207953210	207953210	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:207953210T>C	ENST00000309446.6	-	3	1205	c.829A>G	c.(829-831)Aag>Gag	p.K277E	KLF7_ENST00000412414.2_Missense_Mutation_p.K249E|KLF7_ENST00000423015.1_Silent_p.Q209Q|KLF7_ENST00000458272.1_Missense_Mutation_p.K87E|KLF7_ENST00000467833.1_5'UTR|KLF7_ENST00000421199.1_Missense_Mutation_p.K244E	NM_003709.3	NP_003700.1	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	277					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(3)|liver(1)|lung(4)|skin(1)	11				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		TTGAAGGGCTTTGCACCTGTG	0.537000													14	80					0	0	0.00400662	0	0
LAMB1	3912	broad.mit.edu	37	7	107580657	107580657	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:107580657G>T	ENST00000393561.1	-	23	3794	c.3610C>A	c.(3610-3612)Cac>Aac	p.H1204N	LAMB1_ENST00000222399.6_Missense_Mutation_p.H1180N			P07942	LAMB1_HUMAN	laminin, beta 1	1180	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGCACTGGTGGCAGGGTGTG	0.577000													9	48					1.12685e-05	3.90473e-05	0.00448238	1	0
RET	5979	broad.mit.edu	37	10	43610004	43610004	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:43610004G>C	ENST00000355710.3	+	11	2188	c.1956G>C	c.(1954-1956)ctG>ctC	p.L652L	RET_ENST00000340058.5_Silent_p.L652L	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	652					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CGGTGCTGCTGTCTGCCTTCT	0.627000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				8	42					0	0	0.00307968	0	0
TTN	7273	broad.mit.edu	37	2	179596138	179596138	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179596138G>A	ENST00000589042.1	-	59	17579	c.17355C>T	c.(17353-17355)gcC>gcT	p.A5785A	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.A5468A|TTN_ENST00000342992.6_Silent_p.A4541A|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5468							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTACAAACTGGCCACATTGT	0.423000													42	152					0	0	0.00170553	0	0
CDH9	1007	broad.mit.edu	37	5	26881683	26881683	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:26881683A>T	ENST00000231021.4	-	12	2104	c.1932T>A	c.(1930-1932)ccT>ccA	p.P644P		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	644					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						AAATTATCAGAGGTTCCTTTT	0.388000													11	113					0	0	0.000978159	0	0
SZT2	23334	broad.mit.edu	37	1	43896264	43896264	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:43896264A>G	ENST00000562955.1	+	31	4407	c.4407A>G	c.(4405-4407)ctA>ctG	p.L1469L	SZT2_ENST00000372442.1_Silent_p.L627L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1526						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTGCTGGGCTAGACTCTGCCT	0.567000													10	51					0	0	0.00185496	0	0
YLPM1	56252	broad.mit.edu	37	14	75264921	75264921	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:75264921C>T	ENST00000325680.7	+	5	3045	c.2921C>T	c.(2920-2922)tCa>tTa	p.S974L	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Missense_Mutation_p.S779L	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	779	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTAGCAACATCATCATTAACA	0.448000													22	36					0	0	0.00395357	0	0
PCDH15	65217	broad.mit.edu	37	10	55582648	55582648	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:55582648C>G	ENST00000361849.3	-	34	5238	c.4844G>C	c.(4843-4845)gGa>gCa	p.G1615A	PCDH15_ENST00000395430.1_Missense_Mutation_p.G1610A|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.G1590A|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.G1544A|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.G1613A|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.G1573A	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1613					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTACAGATTCCAGTGTTTTC	0.433000										HNSCC(58;0.16)			26	106					0	0	0.00465635	0	0
TTN	7273	broad.mit.edu	37	2	179430521	179430521	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179430521G>A	ENST00000589042.1	-	326	80562	c.80338C>T	c.(80338-80340)Cct>Tct	p.P26780S	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P17715S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P17840S|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P25139S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P24212S|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P17907S|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25139	Ig-like 128.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGAAGGAGGTTCAGCAGCT	0.478000													36	131					0	0	0.00148497	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777718	43777718	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:43777718A>G	ENST00000389420.3	-	30	4514	c.4515T>C	c.(4513-4515)gtT>gtC	p.V1505V		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1505	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCACCTGACCAACACCTTTCA	0.488000													6	38					0	0	0.00116845	0	0
PCDH7	5099	broad.mit.edu	37	4	30726066	30726066	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:30726066C>A	ENST00000361762.2	+	1	4030	c.3022C>A	c.(3022-3024)Cat>Aat	p.H1008N	PCDH7_ENST00000543491.1_Missense_Mutation_p.H1008N	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	1008					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						TGTTCAGCTTCATCCCCAGTC	0.517000													11	29					5.50884e-06	1.93783e-05	0.00136819	1	0
TAS2R4	50832	broad.mit.edu	37	7	141478324	141478324	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:141478324C>T	ENST00000247881.2	+	1	83	c.36C>T	c.(34-36)gcC>gcT	p.A12A	SSBP1_ENST00000465582.1_Intron	NM_016944.1	NP_058640.1	Q9NYW5	TA2R4_HUMAN	taste receptor, type 2, member 4	12					sensory perception of taste	cilium membrane	taste receptor activity			endometrium(1)|large_intestine(4)|lung(2)	7	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		CTATTATTGCCTCAGTTATTT	0.353000													12	50					0	0	0.000978159	0	0
ZNF135	7694	broad.mit.edu	37	19	58578565	58578565	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:58578565G>A	ENST00000506786.1	+	5	1141	c.587G>A	c.(586-588)gGa>gAa	p.G196E	ZNF135_ENST00000439855.2_Missense_Mutation_p.G238E|ZNF135_ENST00000359978.6_Missense_Mutation_p.G250E|ZNF135_ENST00000511556.1_Missense_Mutation_p.G250E|ZNF135_ENST00000313434.5_Missense_Mutation_p.G238E|ZNF135_ENST00000401053.4_Missense_Mutation_p.G262E			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	250					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		ACGCACACAGGAGAGAGACCT	0.473000													20	115					0	0	0.00152264	0	0
CADM2	253559	broad.mit.edu	37	3	86010741	86010741	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:86010741G>T	ENST00000383699.3	+	8	1541	c.914G>T	c.(913-915)tGt>tTt	p.C305F	CADM2_ENST00000407528.2_Missense_Mutation_p.C296F|CADM2_ENST00000405615.2_Missense_Mutation_p.C298F	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	296	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ACATATCGATGTGAAGCCACA	0.413000													12	91					2.27111e-07	8.78794e-07	0.00136819	1	0
MUC17	140453	broad.mit.edu	37	7	100679317	100679317	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:100679317C>G	ENST00000306151.4	+	3	4684	c.4620C>G	c.(4618-4620)gtC>gtG	p.V1540V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1540	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCTGCTGTCACCAGCACAC	0.478000													58	220					0	0	0.00361006	0	0
XIRP2	129446	broad.mit.edu	37	2	168099116	168099116	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:168099116C>T	ENST00000409195.1	+	9	1303	c.1214C>T	c.(1213-1215)tCa>tTa	p.S405L	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S405L|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.S183L|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	230					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGCCATCATCAGTTGTGAGT	0.428000													24	95					0	0	0.00395357	0	0
THSD1	55901	broad.mit.edu	37	13	52951957	52951957	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:52951957A>G	ENST00000349258.4	-	4	2533	c.1989T>C	c.(1987-1989)agT>agC	p.S663S	THSD1_ENST00000258613.4_Silent_p.S716S|THSD1_ENST00000544466.1_Silent_p.S337S	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	716						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CACGGGTTCCACTTGCCTCTT	0.557000													9	40					0	0	0.000673444	0	0
FLCN	201163	broad.mit.edu	37	17	17122418	17122418	+	Missense_Mutation	SNP	G	G	T	rs138031155	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:17122418G>T	ENST00000285071.4	-	9	1431	c.977C>A	c.(976-978)cCg>cAg	p.P326Q	RP11-45M22.4_ENST00000427497.3_Intron	NM_144997.5	NP_659434.2	Q8NFG4	FLCN_HUMAN	folliculin	326					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|stomach(1)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GGACTCTGCCGGGCCCTGGGT	0.627000									Familial Non-VHL Clear Cell Renal Cancer;Birt-Hogg-Dub syndrome				21	79					5.35356e-11	2.42127e-10	0.00278032	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27539200	27539200	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:27539200G>T	ENST00000574842.1	+	0	469				LRRC37A6P_ENST00000284414.4_RNA																							TGAGTTTGATGGTGACCTGGA	0.532000													19	82					2.94398e-08	1.19562e-07	0.000958276	1	0
ABLIM3	22885	broad.mit.edu	37	5	148626046	148626046	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:148626046G>T	ENST00000506113.1	+	16	1970	c.1486_splice	c.e16-1	p.V496_splice	AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000517451.1_5'UTR|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000326685.7_Splice_Site_p.V401_splice|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000504238.1_Splice_Site_p.V385_splice|ABLIM3_ENST00000356541.3_Splice_Site_p.V385_splice|ABLIM3_ENST00000508983.1_Splice_Site_p.V463_splice|ABLIM3_ENST00000309868.7_Splice_Site_p.V496_splice			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	496					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGACAGTGCCCCGAGCCA	0.473000													11	22					6.40141e-05	0.00021282	0.000978159	1	0
ERBB4	2066	broad.mit.edu	37	2	212530153	212530153	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:212530153C>A	ENST00000342788.4	-	15	2076	c.1766G>T	c.(1765-1767)tGt>tTt	p.C589F	ERBB4_ENST00000436443.1_Missense_Mutation_p.C589F|ERBB4_ENST00000402597.1_Missense_Mutation_p.C589F	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	589	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTTTCCACACAGTTTGGGCC	0.428000										TSP Lung(8;0.080)			5	49					0.00198382	0.00598151	0.00198382	1	0
PCDH15	65217	broad.mit.edu	37	10	55826597	55826597	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:55826597C>A	ENST00000373965.2	-	19	2555	c.2161G>T	c.(2161-2163)Gct>Tct	p.A721S	PCDH15_ENST00000395430.1_Missense_Mutation_p.A714S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.A719S|PCDH15_ENST00000395445.1_Missense_Mutation_p.A721S|PCDH15_ENST00000395433.1_Missense_Mutation_p.A692S|PCDH15_ENST00000373955.1_Missense_Mutation_p.A714S|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.A714S|PCDH15_ENST00000437009.1_Missense_Mutation_p.A643S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000409834.1_Missense_Mutation_p.A325S|PCDH15_ENST00000373957.3_Missense_Mutation_p.A692S|PCDH15_ENST00000320301.6_Missense_Mutation_p.A714S|PCDH15_ENST00000395438.1_Missense_Mutation_p.A714S|PCDH15_ENST00000395432.2_Missense_Mutation_p.A677S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	714	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AACACTGGAGCATTGTCATTG	0.363000										HNSCC(58;0.16)			11	75					5.16669e-11	2.35202e-10	0.000978159	1	0
OR14C36	127066	broad.mit.edu	37	1	248512671	248512671	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248512671G>T	ENST00000317861.1	+	1	595	c.595G>T	c.(595-597)Gtc>Ttc	p.V199F		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						CATGATTGTTGTCTCTGCTCT	0.488000													11	71					5.50884e-06	1.93783e-05	0.00136819	1	0
KMT2E	55904	broad.mit.edu	37	7	104719376	104719376	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:104719376G>T	ENST00000334877.4	+	12	1748	c.1214G>T	c.(1213-1215)cGa>cTa	p.R405L	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000476671.1_Missense_Mutation_p.R405L|KMT2E_ENST00000311117.3_Missense_Mutation_p.R405L|KMT2E_ENST00000257745.4_Missense_Mutation_p.R405L					lysine (K)-specific methyltransferase 2E																		AATGAGGCTCGATTCATCAGG	0.423000													22	70					5.35356e-11	2.42127e-10	0.00278032	1	0
DNAI2	64446	broad.mit.edu	37	17	72278023	72278023	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:72278023C>G	ENST00000579490.1	+	1	373	c.238C>G	c.(238-240)Cgc>Ggc	p.R80G	DNAI2_ENST00000311014.6_Missense_Mutation_p.R23G|DNAI2_ENST00000446837.2_Missense_Mutation_p.R23G|DNAI2_ENST00000582036.1_Missense_Mutation_p.R23G|DNAI2_ENST00000307504.5_5'UTR			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	23					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TTTCTCGGACCGCCAGGCCGA	0.617000									Kartagener syndrome				11	34					0	0	0.00185496	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722958	64722958	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:64722958C>G	ENST00000338957.4	+	5	2447	c.2380C>G	c.(2380-2382)Cag>Gag	p.Q794E	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.Q783E	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	783							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACACCAGTATCAGACCTACAA	0.498000													5	45					0	0	0.000602214	0	0
C4orf40	401137	broad.mit.edu	37	4	71024281	71024281	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:71024281C>A	ENST00000344526.5	+	3	501	c.312C>A	c.(310-312)ctC>ctA	p.L104L	C4orf40_ENST00000502294.1_Silent_p.L104L|C4orf40_ENST00000502441.2_Intron	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	104						extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TTCCTCCTCTCCCTCCTAGGG	0.527000													33	125					9.04072e-19	4.69915e-18	0.00327116	1	0
TRAF6	7189	broad.mit.edu	37	11	36512083	36512083	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:36512083C>A	ENST00000526995.1	-	7	1120	c.874G>T	c.(874-876)Gtc>Ttc	p.V292F	TRAF6_ENST00000348124.5_Missense_Mutation_p.V292F|TRAF6_ENST00000529150.1_5'UTR	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	292	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				AAATTCCGGACCTCTGAGATA	0.483000													24	88					2.65835e-16	1.34657e-15	0.00127121	1	0
TBC1D19	55296	broad.mit.edu	37	4	26638832	26638832	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:26638832G>T	ENST00000264866.4	+	5	572		c.e5-1		TBC1D19_ENST00000515568.1_Splice_Site|TBC1D19_ENST00000511789.1_Splice_Site	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19							intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				TTATGTTTCAGGGAAGTTGGG	0.279000													17	35					2.35188e-11	1.08124e-10	0.00074312	1	0
MADD	8567	broad.mit.edu	37	11	47296557	47296557	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:47296557C>G	ENST00000342922.4	+	3	863	c.506C>G	c.(505-507)tCc>tGc	p.S169C	MADD_ENST00000406482.1_Missense_Mutation_p.S169C|MADD_ENST00000402799.1_Missense_Mutation_p.S169C|MADD_ENST00000402192.2_Missense_Mutation_p.S169C|MADD_ENST00000395344.3_Missense_Mutation_p.S169C|MADD_ENST00000349238.3_Missense_Mutation_p.S169C|MADD_ENST00000407859.3_Missense_Mutation_p.S169C|MADD_ENST00000311027.5_Missense_Mutation_p.S169C|MADD_ENST00000395336.3_Missense_Mutation_p.S169C	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	169					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GGGAGCCGCTCCCGCAACAGT	0.602000													7	34					0	0	0.00448238	0	0
AFF2	2334	broad.mit.edu	37	X	147744018	147744018	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:147744018C>G	ENST00000370460.2	+	3	1249	c.770C>G	c.(769-771)tCt>tGt	p.S257C	AFF2_ENST00000370457.5_Missense_Mutation_p.S253C|AFF2_ENST00000370458.1_Missense_Mutation_p.S253C|AFF2_ENST00000342251.3_Missense_Mutation_p.S253C	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	257					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGCTTCCTCTTTATTAGCT	0.478000													7	138					0	0	0.00198382	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349307	30349307	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:30349307C>G	ENST00000327564.7	+	1	1284	c.1223C>G	c.(1222-1224)tCt>tGt	p.S408C	LRRC37B_ENST00000341671.7_Missense_Mutation_p.S381C|LRRC37B_ENST00000584368.1_Missense_Mutation_p.S393C|LRRC37B_ENST00000394713.3_Missense_Mutation_p.S381C|LRRC37B_ENST00000543378.2_Missense_Mutation_p.S299C			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	381						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				GAACCTTCTTCTACAGCCCTG	0.547000													24	81					0	0	0.00229938	0	0
ABCA7	10347	broad.mit.edu	37	19	1053825	1053825	+	Silent	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:1053825A>C	ENST00000263094.6	+	25	3693	c.3462A>C	c.(3460-3462)acA>acC	p.T1154T	ABCA7_ENST00000433129.1_Silent_p.T1154T|ABCA7_ENST00000435683.2_Silent_p.T1016T	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1154					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCGGACACAGATATGGAGG	0.627000													8	49					0	0	0.000442599	0	0
MTPAP	55149	broad.mit.edu	37	10	30615418	30615418	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:30615418C>A	ENST00000358107.4	-	6	1316	c.1317G>T	c.(1315-1317)cgG>cgT	p.R439R	MTPAP_ENST00000488290.1_5'UTR|MTPAP_ENST00000263063.3_Silent_p.R309R			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	309	PAP-associated.				cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CGAGCGGACACCGGGCATTTA	0.443000													15	108					1.49906e-05	5.13069e-05	0.00244969	1	0
OIT3	170392	broad.mit.edu	37	10	74692166	74692166	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:74692166C>A	ENST00000334011.5	+	9	1740	c.1522C>A	c.(1522-1524)Cgc>Agc	p.R508S		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	508	ZP.					nuclear envelope	calcium ion binding	p.R508S(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					CGAGCGTTCCCGCTGTGCCCA	0.577000													6	99					0.00307968	0.00922579	0.00307968	1	0
DNASE2	1777	broad.mit.edu	37	19	12989306	12989306	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:12989306A>T	ENST00000222219.3	-	5	691	c.599T>A	c.(598-600)gTg>gAg	p.V200E	DNASE2_ENST00000538460.1_Missense_Mutation_p.V145E	NM_001375.2	NP_001366.1	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal	200					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)	7						GCCCTTGACCACATTCTCCAA	0.552000													8	26					0	0	0.00307968	0	0
NBEA	26960	broad.mit.edu	37	13	36228995	36228995	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:36228995A>G	ENST00000400445.3	+	53	8510	c.7976A>G	c.(7975-7977)aAt>aGt	p.N2659S	NBEA_ENST00000379922.3_Missense_Mutation_p.N237S|NBEA_ENST00000310336.4_Missense_Mutation_p.N2659S|NBEA_ENST00000537702.1_Missense_Mutation_p.N452S|NBEA_ENST00000379939.2_Missense_Mutation_p.N2656S|NBEA_ENST00000540320.1_Missense_Mutation_p.N2659S	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2659						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTTTAGCCAATAATTCAGGT	0.348000													4	25					0	0	0.00024832	0	0
MYOF	26509	broad.mit.edu	37	10	95141111	95141111	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:95141111G>T	ENST00000371501.4	-	20	1863	c.1741C>A	c.(1741-1743)Cat>Aat	p.H581N	MYOF_ENST00000359263.4_Missense_Mutation_p.H581N|MYOF_ENST00000371502.4_Missense_Mutation_p.H581N|MYOF_ENST00000358334.5_Missense_Mutation_p.H568N			Q9NZM1	MYOF_HUMAN	myoferlin	581					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTGGCTGAATGAAACACGGCA	0.448000													15	43					0.000422831	0.00133259	0.00400662	1	0
TLR3	7098	broad.mit.edu	37	4	186998018	186998018	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:186998018T>C	ENST00000296795.2	+	2	349	c.245T>C	c.(244-246)gTa>gCa	p.V82A		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	82					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		AGCTTGGATGTAGGATTTAAC	0.418000													19	91					0	0	0.00121646	0	0
SERPINE3	647174	broad.mit.edu	37	13	51922467	51922467	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:51922467C>T	ENST00000524365.1	+	7	1444	c.819C>T	c.(817-819)atC>atT	p.I273I	SERPINE3_ENST00000521255.1_Silent_p.I273I|SERPINE3_ENST00000400389.4_Silent_p.I273I			A8MV23	SERP3_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3	273					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						TGAGCCACATCGAGCCACACC	0.622000													6	18					0	0	0.00198382	0	0
OLFM3	118427	broad.mit.edu	37	1	102269969	102269969	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:102269969G>T	ENST00000370103.4	-	6	1415	c.1202C>A	c.(1201-1203)tCc>tAc	p.S401Y	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Missense_Mutation_p.S421Y|OLFM3_ENST00000536598.1_3'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	421	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GGTTTTGGTGGAATAGGAATA	0.443000													18	163					0.000958276	0.00295982	0.000958276	1	0
TAAR9	134860	broad.mit.edu	37	6	132859864	132859864	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:132859864G>T	ENST00000434551.1	+	0	436					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		CAAGTTTACTGTGTCAGTTTC	0.393000													14	34					9.31168e-06	3.25092e-05	0.00185496	1	0
DDB2	1643	broad.mit.edu	37	11	47236683	47236683	+	Translation_Start_Site	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:47236683A>T	ENST00000256996.4	+	0	191				DDB2_ENST00000378601.3_De_novo_Start_OutOfFrame|DDB2_ENST00000378603.3_De_novo_Start_OutOfFrame|DDB2_ENST00000378600.3_De_novo_Start_OutOfFrame	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa						nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CACACGGAGGACGCGATGGCT	0.587000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				11	79					0	0	0.000673444	0	0
PQLC1	80148	broad.mit.edu	37	18	77703343	77703343	+	Missense_Mutation	SNP	C	C	A	rs139297349		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:77703343C>A	ENST00000397778.2	-	3	505	c.323G>T	c.(322-324)cGc>cTc	p.R108L	PQLC1_ENST00000357575.4_Missense_Mutation_p.R108L|PQLC1_ENST00000409073.1_Missense_Mutation_p.R25L|PQLC1_ENST00000590381.1_Missense_Mutation_p.R108L	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	108						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		AAAGGAGCGGCGCCTGGCGTT	0.587000													28	114					2.47511e-08	1.01407e-07	0.001512	1	0
VPS13B	157680	broad.mit.edu	37	8	100182324	100182324	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:100182324C>T	ENST00000395996.1	+	16	2377	c.2266C>T	c.(2266-2268)Cct>Tct	p.P756S	VPS13B_ENST00000521932.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.P756S|VPS13B_ENST00000355155.1_Missense_Mutation_p.P756S|VPS13B_ENST00000358544.2_Missense_Mutation_p.P756S			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	756					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTACTGCTTACCTGTACCAGT	0.393000													8	103					0	0	0.000442599	0	0
SRPRB	58477	broad.mit.edu	37	3	133524720	133524720	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:133524720G>A	ENST00000466490.2	+	2	313	c.28G>A	c.(28-30)Gca>Aca	p.A10T		NM_021203.3	NP_067026.3	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, B subunit	10						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			breast(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|urinary_tract(2)	12						GCGCCGGGTGGCAGATGGCGG	0.682000													6	30					0	0	0.00198382	0	0
PREX1	57580	broad.mit.edu	37	20	47268019	47268019	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:47268019T>C	ENST00000396220.1	-	22	2592	c.2570A>G	c.(2569-2571)tAt>tGt	p.Y857C	PREX1_ENST00000371941.3_Missense_Mutation_p.Y857C			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	857					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CACATACTCATACACCACGCC	0.637000													5	37					0	0	0.000602214	0	0
NIPAL1	152519	broad.mit.edu	37	4	48032142	48032142	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:48032142G>A	ENST00000295461.5	+	3	385	c.319G>A	c.(319-321)Ggt>Agt	p.G107S	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	107						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						TTTAGGACAAGGTGGACATTC	0.343000													11	52					0	0	0.000978159	0	0
MCMDC2	157777	broad.mit.edu	37	8	67790844	67790844	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:67790844A>G	ENST00000422365.2	+	6	688	c.517A>G	c.(517-519)Aca>Gca	p.T173A	MCMDC2_ENST00000541540.1_Missense_Mutation_p.T110A|MCMDC2_ENST00000492775.1_Missense_Mutation_p.T173A|MCMDC2_ENST00000469823.1_3'UTR|MCMDC2_ENST00000313616.5_Missense_Mutation_p.T173A|MCMDC2_ENST00000396592.3_Missense_Mutation_p.T173A	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	173					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						GCCTGGTGCTACAGAATCTGC	0.333000													28	102					0	0	0.00178596	0	0
CR2	1380	broad.mit.edu	37	1	207646412	207646412	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:207646412C>A	ENST00000367057.3	+	10	2055	c.1866C>A	c.(1864-1866)taC>taA	p.Y622*	CR2_ENST00000367059.3_Nonsense_Mutation_p.Y622*|CR2_ENST00000367058.3_Nonsense_Mutation_p.Y622*|CR2_ENST00000458541.2_Nonsense_Mutation_p.Y595*	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	622	Sushi 10.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CATATTTCTACAATGACACTG	0.438000													14	71					4.36969e-10	1.90218e-09	0.00185496	1	0
OR14C36	127066	broad.mit.edu	37	1	248512663	248512663	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248512663T>C	ENST00000317861.1	+	1	587	c.587T>C	c.(586-588)aTg>aCg	p.M196T		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						AATGAGGTCATGATTGTTGTC	0.493000													13	71					0	0	0.00185496	0	0
KLF8	11279	broad.mit.edu	37	X	56296679	56296679	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:56296679C>A	ENST00000468660.1	+	5	1111	c.823C>A	c.(823-825)Caa>Aaa	p.Q275K	KLF8_ENST00000374928.3_Intron	NM_007250.4	NP_009181.2	O95600	KLF8_HUMAN	Kruppel-like factor 8	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(4)|large_intestine(6)|lung(5)|ovary(1)	16						ACGGATTCACCAATGTGACTT	0.493000													8	53					1.12685e-05	3.90473e-05	0.00448238	1	0
FRMPD1	22844	broad.mit.edu	37	9	37745609	37745609	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:37745609C>A	ENST00000539465.1	+	16	4173	c.3580C>A	c.(3580-3582)Cag>Aag	p.Q1194K	FRMPD1_ENST00000377765.3_Missense_Mutation_p.Q1194K|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1194						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GCAAGGCTGCCAGGCTCAAGA	0.522000													7	61					5.18039e-06	1.85033e-05	0.00307968	1	0
KMT2C	58508	broad.mit.edu	37	7	151945133	151945133	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:151945133T>A	ENST00000355193.2	-	14	2604	c.2386A>T	c.(2386-2388)Atg>Ttg	p.M796L	KMT2C_ENST00000262189.6_Missense_Mutation_p.M796L					lysine (K)-specific methyltransferase 2C																		TTATGCAGCATGTCATGCGAA	0.448000													27	561					0	0	0.001512	0	0
CD163L1	283316	broad.mit.edu	37	12	7585940	7585940	+	Splice_Site	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:7585940C>G	ENST00000416109.2	-	3	493	c.475_splice	c.e3+1	p.G159_splice	CD163L1_ENST00000396630.1_Intron|CD163L1_ENST00000313599.3_Intron	NM_174941.4	NP_777601.2	Q9NR16	C163B_HUMAN	CD163 molecule-like 1	149	SRCR 2.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TAGGTCTTACCTTGCCTTCCT	0.423000													11	33					0	0	0.000978159	0	0
FAT1	2195	broad.mit.edu	37	4	187539651	187539651	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:187539651C>A	ENST00000441802.2	-	10	8298	c.8089G>T	c.(8089-8091)Gaa>Taa	p.E2697*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2697	Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.E2700*(2)|p.E2697*(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGCTGCATTTCCGGTGGAAGG	0.393000										HNSCC(5;0.00058)			17	152					5.3912e-06	1.9207e-05	0.00074312	1	0
PDE1C	5137	broad.mit.edu	37	7	31867932	31867932	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:31867932G>T	ENST00000396184.3	-	13	1463	c.1259C>A	c.(1258-1260)tCc>tAc	p.S420Y	PDE1C_ENST00000396191.1_Missense_Mutation_p.S420Y|PDE1C_ENST00000396193.1_Missense_Mutation_p.S480Y|PDE1C_ENST00000396182.2_Missense_Mutation_p.S420Y|PDE1C_ENST00000321453.7_Missense_Mutation_p.S420Y	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	420	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AACCATAGTGGACTTTCGGTC	0.468000													8	34					1.06961e-07	4.23287e-07	0.00307968	1	0
PSG4	5672	broad.mit.edu	37	19	43708326	43708326	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43708326C>A	ENST00000405312.3	-	2	379	c.142G>T	c.(142-144)Ggg>Tgg	p.G48W	PSG4_ENST00000244295.9_Missense_Mutation_p.G48W|PSG4_ENST00000433626.2_Missense_Mutation_p.G48W	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	48	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				ACATCCTTCCCCTCAGAAACT	0.463000													32	179					1.71298e-08	7.05971e-08	0.00375469	1	0
N4BP2L2	10443	broad.mit.edu	37	13	33110497	33110497	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:33110497T>C	ENST00000267068.3	-	2	832	c.668A>G	c.(667-669)gAt>gGt	p.D223G	N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000357505.6_Intron|N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.D223G	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	223										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATTACTAAGATCTTTCTTTTC	0.353000													11	73					0	0	0.00136819	0	0
CAMK4	814	broad.mit.edu	37	5	110814169	110814169	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:110814169C>A	ENST00000282356.4	+	9	1190	c.792C>A	c.(790-792)ccC>ccA	p.P264P	CAMK4_ENST00000512453.1_Silent_p.P264P	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	264	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TTATCTCCCCCTGGTGGGATG	0.333000													30	69					2.85442e-18	1.47814e-17	0.00209593	1	0
OXGR1	27199	broad.mit.edu	37	13	97639970	97639970	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:97639970G>T	ENST00000298440.1	-	4	287	c.44C>A	c.(43-45)cCc>cAc	p.P15H	OXGR1_ENST00000543457.1_Missense_Mutation_p.P15H	NM_080818.3	NP_543008.3	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	15						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			NS(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TGCATAATCGGGGAAATCAGA	0.403000													18	88					1.28384e-07	5.00949e-07	0.00188189	1	0
SNTG1	54212	broad.mit.edu	37	8	51314850	51314850	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:51314850G>T	ENST00000522124.1	+	4	769	c.108G>T	c.(106-108)ttG>ttT	p.L36F	SNTG1_ENST00000518864.1_Missense_Mutation_p.L36F|SNTG1_ENST00000517473.1_Missense_Mutation_p.L36F|SNTG1_ENST00000276467.5_Missense_Mutation_p.L36F	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	36					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AAGACATTTTGATGATCCAGG	0.383000													25	121					6.32553e-13	3.05954e-12	0.00465635	1	0
ASXL1	171023	broad.mit.edu	37	20	31024829	31024829	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:31024829G>T	ENST00000375687.4	+	13	4738	c.4314G>T	c.(4312-4314)caG>caT	p.Q1438H	ASXL1_ENST00000306058.5_Missense_Mutation_p.Q1433H	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1438					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						GCATCAAGCAGGCATTTTATG	0.517000			"""F, N, Mis"""		"""MDS, CMML"""								10	68					1.08611e-07	4.24985e-07	0.000978159	1	0
HCLS1	3059	broad.mit.edu	37	3	121350993	121350993	+	Missense_Mutation	SNP	C	C	A	rs112494135		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:121350993C>A	ENST00000314583.3	-	13	1370	c.1279G>T	c.(1279-1281)Gtg>Ttg	p.V427L	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.V390L	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	427					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		CCCAGagccacagccccagcc	0.537000													9	48					0.000274275	0.00086833	0.00448238	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725926	140725926	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:140725926G>A	ENST00000253812.6	+	1	2326	c.2326G>A	c.(2326-2328)Gcg>Acg	p.A776T	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCAACTATGCGGACACGCT	0.547000													25	69					0	0	0.00127121	0	0
C1orf101	257044	broad.mit.edu	37	1	244747191	244747191	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:244747191G>T	ENST00000366534.4	+	13	2089	c.2035G>T	c.(2035-2037)Gtt>Ttt	p.V679F	C1orf101_ENST00000366533.4_Missense_Mutation_p.V679F|C1orf101_ENST00000366531.3_Missense_Mutation_p.V528F|C1orf101_ENST00000473875.1_3'UTR	NM_001130957.1	NP_001124429.1	Q5SY80	CA101_HUMAN	chromosome 1 open reading frame 101	679						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	36	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TCTTGTGCTGGTTCAGTTTCG	0.423000													14	26					0.000219431	0.000702685	0.00244969	1	0
MAP2K2	5605	broad.mit.edu	37	19	4110509	4110509	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:4110509T>A	ENST00000262948.5	-	3	701	c.448A>T	c.(448-450)Atg>Ttg	p.M150L	MAP2K2_ENST00000394867.4_Missense_Mutation_p.M53L|MAP2K2_ENST00000599345.1_5'UTR	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	150	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACTCACCATGTGTTCCATG	0.627000													6	44					0	0	0.00198382	0	0
COL4A4	1286	broad.mit.edu	37	2	227876937	227876937	+	Silent	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:227876937A>C	ENST00000396625.3	-	45	4500	c.4293T>G	c.(4291-4293)cgT>cgG	p.R1431R	COL4A4_ENST00000329662.7_Silent_p.R1428R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1431	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGTCACCTTTACGTCCGGGAG	0.537000													3	19					0	0	0.00024832	0	0
OR5B3	441608	broad.mit.edu	37	11	58170847	58170847	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:58170847A>T	ENST00000309403.2	-	1	35	c.36T>A	c.(34-36)ctT>ctA	p.L12L		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTAGTCCTAGAAGAATGAATT	0.383000													19	89					0	0	0.00152264	0	0
OR13C4	138804	broad.mit.edu	37	9	107289037	107289037	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:107289037C>A	ENST00000277216.3	-	1	453	c.454G>T	c.(454-456)Ggt>Tgt	p.G152C		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TTGATTCCACCAGAAAGCCAT	0.428000													19	98					8.34094e-07	3.09838e-06	0.00121646	1	0
DMRTB1	63948	broad.mit.edu	37	1	53930460	53930460	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:53930460C>A	ENST00000371445.3	+	3	956	c.901C>A	c.(901-903)Cca>Aca	p.P301T		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	301	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						GCCACCGCCACCACCACCTCC	0.637000													7	71					5.18039e-06	1.85033e-05	0.00307968	1	0
LCE3A	353142	broad.mit.edu	37	1	152595328	152595328	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152595328A>G	ENST00000335674.1	-	1	251	c.252T>C	c.(250-252)agT>agC	p.S84S		NM_178431.1	NP_848518.1	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	84					keratinization					endometrium(1)|lung(5)	6	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCCGCAGAACTGTGGCCAC	0.547000													7	54					0	0	0.00198382	0	0
FAM194A	131831	broad.mit.edu	37	3	150396332	150396332	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:150396332C>A	ENST00000295910.6	-	10	1173	c.1121G>T	c.(1120-1122)cGc>cTc	p.R374L	FAM194A_ENST00000491361.1_Missense_Mutation_p.R228L	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	374										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TGTTTTTAAGCGCTTTGAATC	0.269000													11	32					6.40141e-05	0.00021282	0.000978159	1	0
KIF20B	9585	broad.mit.edu	37	10	91488933	91488933	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:91488933G>T	ENST00000416354.1	+	18	2392	c.2320G>T	c.(2320-2322)Gat>Tat	p.D774Y	KIF20B_ENST00000260753.4_Missense_Mutation_p.D734Y|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000371728.3_Missense_Mutation_p.D774Y|KIF20B_ENST00000394289.2_Missense_Mutation_p.D774Y			Q96Q89	KI20B_HUMAN	kinesin family member 20B	774					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AAATATAATTGATCAAAAAGA	0.244000													9	57					0.000442599	0.00138238	0.000442599	1	0
FBXO18	84893	broad.mit.edu	37	10	5960359	5960359	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:5960359C>A	ENST00000379999.5	+	14	2275	c.2171C>A	c.(2170-2172)cCg>cAg	p.P724Q	FBXO18_ENST00000379994.1_Intron|FBXO18_ENST00000397269.3_Missense_Mutation_p.P160Q|FBXO18_ENST00000362091.4_Missense_Mutation_p.P673Q	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	673					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding	p.P724Q(1)		NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						GTAGGGGACCCGCACCAGCAG	0.537000													7	98					0.00307968	0.00922579	0.00307968	1	0
SLC2A14	144195	broad.mit.edu	37	12	7984305	7984305	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:7984305G>T	ENST00000543909.1	-	9	995	c.236C>A	c.(235-237)tCt>tAt	p.S79Y	SLC2A14_ENST00000535295.1_Intron|SLC2A14_ENST00000340749.5_Missense_Mutation_p.S56Y|SLC2A14_ENST00000542505.1_Intron|SLC2A14_ENST00000542546.1_Intron|SLC2A14_ENST00000396589.2_Missense_Mutation_p.S79Y|SLC2A14_ENST00000539924.1_Missense_Mutation_p.S94Y|SLC2A14_ENST00000431042.2_Missense_Mutation_p.S56Y			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	79					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		CAGCACCTCAGAGGGAGGGGC	0.463000											OREG0021654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	53					6.31663e-08	2.51402e-07	0.00316338	1	0
GAN	8139	broad.mit.edu	37	16	81388292	81388292	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:81388292G>T	ENST00000248272.3	+	3	727	c.565G>T	c.(565-567)Gtt>Ttt	p.V189F		NM_022041.3	NP_071324.1	Q9H2C0	GAN_HUMAN	gigaxonin	189	BACK.				cell death	cytoplasm|neurofilament	protein binding	p.V189F(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)	25		Colorectal(91;0.153)				GAAGTTAAACGTTGGCAATGA	0.383000													29	75					9.39395e-14	4.67349e-13	0.00106085	1	0
DNM1	1759	broad.mit.edu	37	9	130984836	130984836	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:130984836C>G	ENST00000341179.7	+	8	1181	c.1089C>G	c.(1087-1089)aaC>aaG	p.N363K	DNM1_ENST00000475805.1_Missense_Mutation_p.N363K|DNM1_ENST00000393594.3_Missense_Mutation_p.N363K|DNM1_ENST00000372923.3_Missense_Mutation_p.N363K|DNM1_ENST00000486160.1_Missense_Mutation_p.N363K	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	363					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						CCCGCATTAACCGAATCTTCC	0.592000													6	45					0	0	0.00448238	0	0
VPS13B	157680	broad.mit.edu	37	8	100148930	100148930	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:100148930G>T	ENST00000395996.1	+	12	1712	c.1601G>T	c.(1600-1602)gGg>gTg	p.G534V	VPS13B_ENST00000357162.2_Missense_Mutation_p.G534V|VPS13B_ENST00000355155.1_Missense_Mutation_p.G534V|VPS13B_ENST00000358544.2_Missense_Mutation_p.G534V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	534					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAACGGTTTGGGGCTTTTTAT	0.368000													41	183					3.77016e-25	2.0515e-24	0.00321405	1	0
ARHGAP24	83478	broad.mit.edu	37	4	86491874	86491874	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:86491874G>T	ENST00000395184.1	+	2	646	c.180_splice	c.e2+1	p.L60_splice	ARHGAP24_ENST00000506421.1_3'UTR|ARHGAP24_ENST00000503995.1_Splice_Site_p.L60_splice	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	60	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CCAAGCCCTTGGTGAGTAGGA	0.458000													14	53					1.5739e-10	7.0046e-10	0.00400662	1	0
HMCN1	83872	broad.mit.edu	37	1	186008104	186008104	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:186008104G>T	ENST00000271588.4	+	38	6224	c.5995G>T	c.(5995-5997)Gct>Tct	p.A1999S	HMCN1_ENST00000367492.2_Missense_Mutation_p.A1999S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1999	Ig-like C2-type 17.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTCAGCTGGAGCTACAGAGTT	0.408000													18	81					2.35188e-11	1.08124e-10	0.00074312	1	0
OR5M9	390162	broad.mit.edu	37	11	56230095	56230095	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:56230095G>T	ENST00000279791.1	-	1	782	c.783C>A	c.(781-783)ccC>ccA	p.P261P		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P261P(1)|p.P261Q(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					ATTCCTCAGTGGGTCTCCTGA	0.493000													8	38					0.000157383	0.000509849	0.00307968	1	0
NMRK2	27231	broad.mit.edu	37	19	3941117	3941117	+	Missense_Mutation	SNP	C	C	A	rs142587749		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:3941117C>A	ENST00000168977.2	+	7	734	c.444C>A	c.(442-444)caC>caA	p.H148Q	NMRK2_ENST00000599576.1_Intron|NMRK2_ENST00000593949.1_Missense_Mutation_p.H153Q	NM_170678.2	NP_733778.1			nicotinamide riboside kinase 2																		TCGATGGCCACGTGTGGCCCA	0.612000													5	36					2.0095e-06	7.30869e-06	0.00198382	1	0
NXPH3	11248	broad.mit.edu	37	17	47656161	47656161	+	Silent	SNP	G	G	A	rs36092288		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:47656161G>A	ENST00000328741.5	+	2	620	c.258G>A	c.(256-258)ccG>ccA	p.P86P	NXPH3_ENST00000513748.1_Silent_p.P86P	NM_007225.2	NP_009156.2	O95157	NXPH3_HUMAN	neurexophilin 3	86	III.				neuropeptide signaling pathway	extracellular region				endometrium(2)|large_intestine(3)|lung(4)|pancreas(1)|skin(2)	12	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CCAACCGCCCGAACCACAGCC	0.627000													4	23					0	0	0.00024832	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33616098	33616098	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:33616098C>A	ENST00000504830.1	-	15	2558	c.2223G>T	c.(2221-2223)ctG>ctT	p.L741L	ADAMTS12_ENST00000352040.3_Silent_p.L656L|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	741	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCCTGATGGCCAGGAAGTTTC	0.438000										HNSCC(64;0.19)			11	74					7.03913e-09	2.93578e-08	0.00136819	1	0
CELA2A	63036	broad.mit.edu	37	1	15783627	15783627	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:15783627G>T	ENST00000359621.4	+	2	112	c.87G>T	c.(85-87)gtG>gtT	p.V29V	CELA2A_ENST00000497590.1_3'UTR	NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	29	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						TGACTAGGGTGGTTGGCGGTG	0.567000													8	30					1.58986e-06	5.82811e-06	0.000673444	1	0
TAF1L	138474	broad.mit.edu	37	9	32630112	32630112	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:32630112A>T	ENST00000242310.4	-	1	5555	c.5466T>A	c.(5464-5466)gaT>gaA	p.D1822E		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1822					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTCCGTGCCCATCCTTGTGTT	0.493000													6	31					0	0	0.00116845	0	0
REG1A	5967	broad.mit.edu	37	2	79350037	79350037	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79350037G>A	ENST00000233735.1	+	5	495	c.392G>A	c.(391-393)aGt>aAt	p.S131N		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	131	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCCCCAAGCAGTGTTAATCCT	0.577000													12	61					0	0	0.000978159	0	0
FANCD2	2177	broad.mit.edu	37	3	10140527	10140527	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:10140527G>T	ENST00000287647.3	+	43	4402	c.4309G>T	c.(4309-4311)Ggc>Tgc	p.G1437C	FANCD2_ENST00000383807.1_Intron|FANCD2OS_ENST00000524279.1_Intron|FANCD2_ENST00000383806.1_Intron|FANCD2_ENST00000419585.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1437					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ACCAGAGTCTGGCACTGATGG	0.458000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				14	50					3.27435e-08	1.32592e-07	0.00244969	1	0
ITGA8	8516	broad.mit.edu	37	10	15600165	15600165	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:15600165C>T	ENST00000378076.3	-	26	3027	c.2674G>A	c.(2674-2676)Gcc>Acc	p.A892T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	892					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGCAAAAAGGCGCTGAGCTCA	0.458000													12	40					0	0	0.00185496	0	0
REG1A	5967	broad.mit.edu	37	2	79348783	79348783	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79348783C>A	ENST00000233735.1	+	3	263	c.160C>A	c.(160-162)Cgt>Agt	p.R54S		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	54	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TAATGAAGACCGTGAGACCTG	0.567000													22	101					1.96292e-10	8.65301e-10	0.00152264	1	0
KCTD7	154881	broad.mit.edu	37	7	66240365	66240365	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:66240365G>A	ENST00000380828.2	+	5	605	c.451G>A	c.(451-453)Gtc>Atc	p.V151I	KCTD7_ENST00000510829.2_Missense_Mutation_p.V111I|KCTD7_ENST00000451741.2_Missense_Mutation_p.V111I|RABGEF1_ENST00000437078.2_Missense_Mutation_p.V125I|RABGEF1_ENST00000450873.2_Missense_Mutation_p.V111I|RABGEF1_ENST00000284957.5_Missense_Mutation_p.V111I|RABGEF1_ENST00000484547.2_3'UTR|RABGEF1_ENST00000439720.2_Missense_Mutation_p.V124I			Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	0						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						ATCTTCCAGGGTCGGATCAAA	0.443000													13	50					0	0	0.00244969	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765873	77765873	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:77765873G>T	ENST00000521891.2	+	10	7164	c.6716G>T	c.(6715-6717)aGg>aTg	p.R2239M	ZFHX4_ENST00000518282.1_Missense_Mutation_p.R2213M|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R2194M|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R2194M	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2194						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACCAGCTTAGGGTTCTGCAA	0.398000										HNSCC(33;0.089)			17	20					3.41278e-10	1.49028e-09	0.000566183	1	0
ANK2	287	broad.mit.edu	37	4	114278909	114278909	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:114278909G>T	ENST00000357077.4	+	38	9188	c.9135G>T	c.(9133-9135)tgG>tgT	p.W3045C	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.W3012C|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3012					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGATTCTTGGAGTGAAATTC	0.413000													31	105					3.03874e-20	1.6034e-19	0.00327116	1	0
MAPK1	5594	broad.mit.edu	37	22	22142565	22142565	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:22142565G>A	ENST00000215832.6	-	6	1025	c.837C>T	c.(835-837)ttC>ttT	p.F279F	MAPK1_ENST00000544786.1_Intron|MAPK1_ENST00000398822.3_Silent_p.F279F	NM_002745.4	NP_002736.3	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	279	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	CAGCATTTGGGAACAGCCTGT	0.363000													13	63					0	0	0.00400662	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765484	18765484	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:18765484G>C	ENST00000304081.4	-	5	861	c.761C>G	c.(760-762)tCc>tGc	p.S254C	NT5C1B_ENST00000359846.2_Missense_Mutation_p.S314C|NT5C1B_ENST00000600945.1_Missense_Mutation_p.S314C|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.S314C	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAGCGCGCAGGATGAGAGAGC	0.537000													21	84					0	0	0.00278032	0	0
ZAK	51776	broad.mit.edu	37	2	174085998	174085998	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:174085998G>T	ENST00000338983.3	+	12	1303	c.1108G>T	c.(1108-1110)Ggc>Tgc	p.G370C	MLTK_ENST00000409176.2_Intron|MLTK_ENST00000539448.1_Missense_Mutation_p.G370C|MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000431503.2_Missense_Mutation_p.G269C|MLK7-AS1_ENST00000422703.1_RNA|MLTK_ENST00000375213.3_Intron	NM_133646.2	NP_598407.1																					GGAGGGCCATGGCATGAACCC	0.463000													11	72					4.68919e-08	1.89335e-07	0.000673444	1	0
ZSCAN4	201516	broad.mit.edu	37	19	58187796	58187796	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:58187796G>C	ENST00000318203.5	+	3	980	c.283G>C	c.(283-285)Ggt>Cgt	p.G95R		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	95	SCAN box.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTTATGATTGGTGGCCACTG	0.398000													15	79					0	0	0.000566183	0	0
DDX1	1653	broad.mit.edu	37	2	15760365	15760365	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:15760365G>T	ENST00000381341.2	+	18	1629	c.1240G>T	c.(1240-1242)Gat>Tat	p.D414Y	DDX1_ENST00000233084.3_Missense_Mutation_p.D414Y			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	414	Helicase ATP-binding.|Necessary for interaction with RELA.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GCATTCTTTCGATGTAAAGAA	0.363000													24	93					3.73808e-20	1.96496e-19	0.000878237	1	0
MARCH11	441061	broad.mit.edu	37	5	16067856	16067856	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:16067856G>T	ENST00000332432.8	-	4	1132	c.933C>A	c.(931-933)cgC>cgA	p.R311R		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	311						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						CAGCTCGCCAGCGCTTAAACA	0.428000													10	47					6.40141e-05	0.00021282	0.000978159	1	0
CNTN1	1272	broad.mit.edu	37	12	41316083	41316083	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:41316083G>T	ENST00000551295.2	+	5	370	c.253G>T	c.(253-255)Gat>Tat	p.D85Y	CNTN1_ENST00000347616.1_Missense_Mutation_p.D85Y|CNTN1_ENST00000547702.1_Missense_Mutation_p.D85Y|CNTN1_ENST00000360099.3_Missense_Mutation_p.D85Y|CNTN1_ENST00000547849.1_Missense_Mutation_p.D85Y|CNTN1_ENST00000348761.2_Missense_Mutation_p.D74Y	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	85	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGGGGACGTTGATCTCACAAG	0.393000													17	54					7.45023e-12	3.54204e-11	0.00152264	1	0
TACR3	6870	broad.mit.edu	37	4	104512718	104512718	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:104512718G>T	ENST00000304883.2	-	4	1151	c.1011C>A	c.(1009-1011)gtC>gtA	p.V337V	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	337						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TAGCCAGGTAGACCTGCTGGA	0.398000													16	94					6.72482e-11	3.03161e-10	0.00316338	1	0
C2orf78	388960	broad.mit.edu	37	2	74042529	74042529	+	Silent	SNP	C	C	A	rs143445466	by1000genomes	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:74042529C>A	ENST00000409561.1	+	3	1300	c.1179C>A	c.(1177-1179)ccC>ccA	p.P393P		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	393										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TAGAAATCCCCGATATTCACC	0.448000													8	17					1.12685e-05	3.90473e-05	0.00448238	1	0
COL17A1	1308	broad.mit.edu	37	10	105815145	105815145	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:105815145T>A	ENST00000353479.5	-	19	1992	c.1702A>T	c.(1702-1704)Agc>Tgc	p.S568C	COL17A1_ENST00000369733.3_Missense_Mutation_p.S568C|COL17A1_ENST00000480127.1_5'UTR	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	568	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGCCAGGGCTTCCTCGGAGA	0.448000													16	61					0	0	0.00400662	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54674315	54674315	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:54674315G>T	ENST00000230640.5	+	17	2237		c.e17+1		SKIV2L2_ENST00000545714.1_Splice_Site	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)						maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTTGGTAAAGGTATGTCATTG	0.274000													7	34					8.12818e-05	0.000265788	0.00198382	1	0
ZNF384	171017	broad.mit.edu	37	12	6776900	6776900	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:6776900C>T	ENST00000396795.1	-	9	2028	c.1531G>A	c.(1531-1533)Gag>Aag	p.E511K	ZNF384_ENST00000361959.3_Missense_Mutation_p.E572K|ZNF384_ENST00000396801.3_Missense_Mutation_p.E572K|ZNF384_ENST00000319770.3_Missense_Mutation_p.E495K|RP4-761J14.8_ENST00000589924.1_RNA|ZNF384_ENST00000396799.2_Missense_Mutation_p.E511K|ZNF384_ENST00000355772.4_Missense_Mutation_p.E456K			Q8TF68	ZN384_HUMAN	zinc finger protein 384	572	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						GCCAGGTGCTCCACCTGGATG	0.557000			T	"""EWSR1, TAF15 """	ALL								12	109					0	0	0.000978159	0	0
DBX2	440097	broad.mit.edu	37	12	45417504	45417504	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:45417504G>T	ENST00000332700.6	-	3	844	c.673C>A	c.(673-675)Cta>Ata	p.L225I		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	225						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GATTCCTTTAGTCCCAAGTTG	0.423000													43	197					1.91693e-13	9.43563e-13	0.00361006	1	0
JADE3	9767	broad.mit.edu	37	X	46917717	46917717	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:46917717C>G	ENST00000218343.4	+	11	2008	c.1710C>G	c.(1708-1710)agC>agG	p.S570R	PHF16_ENST00000397189.1_Missense_Mutation_p.S570R	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		570					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						CTGACAGCAGCTCATCTGTTC	0.458000													8	53					0	0	0.000442599	0	0
LAMB1	3912	broad.mit.edu	37	7	107575913	107575913	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:107575913C>G	ENST00000393561.1	-	25	4391	c.4207G>C	c.(4207-4209)Gat>Cat	p.D1403H	LAMB1_ENST00000222399.6_Missense_Mutation_p.D1379H|LAMB1_ENST00000474380.1_5'UTR			P07942	LAMB1_HUMAN	laminin, beta 1	1379	Domain alpha.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCAGTTCATCAAGGAGGCGA	0.512000													20	162					0	0	0.00152264	0	0
SEPT6	23157	broad.mit.edu	37	X	118767439	118767439	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:118767439C>T	ENST00000394610.1	-	8	1237	c.973G>A	c.(973-975)Gag>Aag	p.E325K	SEPT6_ENST00000343984.5_Missense_Mutation_p.E325K|SEPT6_ENST00000360156.7_Missense_Mutation_p.E325K|SEPT6_ENST00000394617.2_Missense_Mutation_p.E355K|SEPT6_ENST00000394616.4_Missense_Mutation_p.E267K|SEPT6_ENST00000489216.1_Missense_Mutation_p.E325K|SEPT6_ENST00000354416.3_Missense_Mutation_p.E325K|SEPT6_ENST00000354228.4_Missense_Mutation_p.E325K	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	325					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						CTTTTGGCCTCATATGTCTCC	0.448000			T	MLL	AML								62	119					0	0	0.00361006	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922542	17922542	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:17922542C>T	ENST00000318683.6	+	3	877	c.730C>T	c.(730-732)Ccc>Tcc	p.P244S	B3GNT3_ENST00000595387.1_Missense_Mutation_p.P244S	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	244					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						AAACGTGGGCCCCATCCGGGC	0.567000													6	27					0	0	0.00198382	0	0
SUCLG2	8801	broad.mit.edu	37	3	67546341	67546341	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:67546341C>A	ENST00000307227.5	-	9	970	c.943G>T	c.(943-945)Gct>Tct	p.A315S	SUCLG2_ENST00000493112.1_Missense_Mutation_p.A315S|SUCLG2_ENST00000492795.1_Missense_Mutation_p.A315S	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	315					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TCACAAGTAGCCATGGCGAGC	0.438000													10	21					3.07112e-06	1.10544e-05	0.000978159	1	0
TBX22	50945	broad.mit.edu	37	X	79279562	79279562	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:79279562G>T	ENST00000373294.5	+	3	385	c.356_splice	c.e3-1	p.R119_splice	TBX22_ENST00000373296.3_Splice_Site_p.R119_splice|TBX22_ENST00000442340.1_5'UTR|TBX22_ENST00000373291.1_5'UTR	NM_016954.2	NP_058650.1	Q9Y458	TBX22_HUMAN	T-box 22	119					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTTCTTACAGGCGGATGTTCC	0.478000													6	63					3.59834e-05	0.000121368	0.00116845	1	0
USP29	57663	broad.mit.edu	37	19	57640279	57640279	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:57640279A>T	ENST00000254181.4	+	4	690	c.236A>T	c.(235-237)aAc>aTc	p.N79I	USP29_ENST00000598197.1_Missense_Mutation_p.N79I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	79					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTGAAAAACAACGTGTTCTTG	0.333000													10	43					0	0	0.000442599	0	0
BCAN	63827	broad.mit.edu	37	1	156628521	156628521	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:156628521G>A	ENST00000329117.4	+	13	2960	c.2624G>A	c.(2623-2625)aGa>aAa	p.R875K	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	875					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGCCCAGAAGACCTGTGAGT	0.607000													11	38					0	0	0.000978159	0	0
OR5D16	390144	broad.mit.edu	37	11	55606407	55606407	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55606407C>A	ENST00000378396.1	+	1	180	c.180C>A	c.(178-180)ccC>ccA	p.P60P		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TGCATACCCCCATGTATTTTT	0.433000													12	150					0.000978159	0.00300789	0.000978159	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128958013	128958013	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:128958013C>A	ENST00000274487.4	+	10	1869	c.1724C>A	c.(1723-1725)cCa>cAa	p.P575Q	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	575	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTTTTGGGCCATTGGCTTCT	0.443000													10	35					5.50884e-06	1.93783e-05	0.00136819	1	0
VPS41	27072	broad.mit.edu	37	7	38857421	38857421	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:38857421T>A	ENST00000310301.4	-	7	500	c.446A>T	c.(445-447)aAg>aTg	p.K149M	VPS41_ENST00000395969.2_Missense_Mutation_p.K124M	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	149					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ACTTACCTTCTTCCCTCCGGT	0.433000													21	60					0	0	0.00278032	0	0
LINS	55180	broad.mit.edu	37	15	101109855	101109855	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:101109855C>A	ENST00000314742.8	-	7	2084	c.1862G>T	c.(1861-1863)cGg>cTg	p.R621L		NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	621								p.R621fs*13(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						TTGAGAGGCCCGGGGGGAAGA	0.527000													5	64					0.00116845	0.00354607	0.00116845	1	0
MARK1	4139	broad.mit.edu	37	1	220825454	220825454	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:220825454G>C	ENST00000402574.1	+	15	2295	c.1293G>C	c.(1291-1293)ctG>ctC	p.L431L	MARK1_ENST00000366918.4_Silent_p.L544L|MARK1_ENST00000366917.4_Silent_p.L566L	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	566					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AAGTCACACTGCCAACCATTA	0.473000													13	78					0	0	0.00244969	0	0
PNPLA5	150379	broad.mit.edu	37	22	44285300	44285300	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:44285300A>T	ENST00000216177.4	-	4	743	c.611T>A	c.(610-612)cTg>cAg	p.L204Q	PNPLA5_ENST00000593866.1_Missense_Mutation_p.L90Q|PNPLA5_ENST00000381198.2_Missense_Mutation_p.L90Q|PNPLA5_ENST00000597664.1_Missense_Mutation_p.L204Q	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	204					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CAGCTCATGCAGGTTGGGGGA	0.567000													15	74					0	0	0.000566183	0	0
OLFM3	118427	broad.mit.edu	37	1	102269968	102269968	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:102269968G>T	ENST00000370103.4	-	6	1416	c.1203C>A	c.(1201-1203)tcC>tcA	p.S401S	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Silent_p.S421S|OLFM3_ENST00000536598.1_3'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	421	Olfactomedin-like.					extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGGTTTTGGTGGAATAGGAAT	0.443000													20	165					0.00152264	0.00461095	0.00152264	1	0
ZBTB41	360023	broad.mit.edu	37	1	197150178	197150178	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:197150178C>G	ENST00000367405.4	-	5	1684	c.1616G>C	c.(1615-1617)tGt>tCt	p.C539S	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						ACCATGAGTACATTCTATATG	0.358000													15	59					0	0	0.00244969	0	0
MYO6	4646	broad.mit.edu	37	6	76599836	76599836	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:76599836G>T	ENST00000369981.3	+	26	3000	c.2721G>T	c.(2719-2721)gaG>gaT	p.E907D	MYO6_ENST00000369985.4_Missense_Mutation_p.E907D|MYO6_ENST00000369977.3_Missense_Mutation_p.E907D|MYO6_ENST00000369975.1_Missense_Mutation_p.E907D			Q9UM54	MYO6_HUMAN	myosin VI	907					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAAGCTCAGAGGAACTCCTCA	0.368000													21	67					6.21321e-17	3.17033e-16	0.00278032	1	0
PZP	5858	broad.mit.edu	37	12	9353608	9353608	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:9353608C>A	ENST00000261336.2	-	6	578	c.550G>T	c.(550-552)Gct>Tct	p.A184S	PZP_ENST00000381997.2_Missense_Mutation_p.A53S	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TTGATGCCAGCTTCTAGCTTG	0.478000													18	87					1.50039e-11	6.99011e-11	0.00188189	1	0
HORMAD1	84072	broad.mit.edu	37	1	150681431	150681431	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:150681431A>C	ENST00000368993.2	-	8	439	c.334T>G	c.(334-336)Tca>Gca	p.S112A	HORMAD1_ENST00000368995.4_Missense_Mutation_p.S32A|HORMAD1_ENST00000361824.2_Missense_Mutation_p.S112A|HORMAD1_ENST00000322343.7_Missense_Mutation_p.S105A			Q86X24	HORM1_HUMAN	HORMA domain containing 1	112	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TAACATTCTGAAATTGTCTTA	0.303000													5	45					0	0	0.00116845	0	0
ITGA2	3673	broad.mit.edu	37	5	52371050	52371050	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:52371050G>T	ENST00000296585.5	+	23	2884		c.e23-1			NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)						axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TCTTTCTATAGTGAAAGCCAA	0.353000													18	43					2.35188e-11	1.08124e-10	0.00074312	1	0
OR2B11	127623	broad.mit.edu	37	1	247614745	247614745	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:247614745G>C	ENST00000318749.6	-	1	563	c.540C>G	c.(538-540)aaC>aaG	p.N180K		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CACAGAAAAAGTTGTTCAGCA	0.592000													5	19					0	0	0.00116845	0	0
PNPLA8	50640	broad.mit.edu	37	7	108128275	108128275	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:108128275C>G	ENST00000422087.1	-	10	2212	c.1806G>C	c.(1804-1806)tgG>tgC	p.W602C	PNPLA8_ENST00000453144.1_Missense_Mutation_p.W502C|PNPLA8_ENST00000388728.5_Intron|PNPLA8_ENST00000426128.2_Intron|PNPLA8_ENST00000436062.1_Missense_Mutation_p.W602C|PNPLA8_ENST00000257694.8_Missense_Mutation_p.W602C	NM_015723.3	NP_056538.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	602	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						TAATGGCCTGCCACATTTTAT	0.388000													11	47					0	0	0.000978159	0	0
TNXB	7148	broad.mit.edu	37	6	32036389	32036389	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:32036389G>A	ENST00000375244.3	-	17	6199	c.5998C>T	c.(5998-6000)Cct>Tct	p.P2000S	TNXB_ENST00000375247.2_Missense_Mutation_p.P2000S			P22105	TENX_HUMAN	tenascin XB	2082	Fibronectin type-III 12.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGGGAGTCAGGGGTGGCATCT	0.632000													7	17					0	0	0.00448238	0	0
ANKFN1	162282	broad.mit.edu	37	17	54543847	54543847	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:54543847A>T	ENST00000566473.2	+	14	1697	c.1697A>T	c.(1696-1698)cAg>cTg	p.Q566L	ANKFN1_ENST00000318698.2_Missense_Mutation_p.Q566L			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	566										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AAATGGATGCAGATCTCAAAG	0.398000													8	37					0	0	0.00307968	0	0
CSNK1G3	1456	broad.mit.edu	37	5	122927092	122927092	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:122927092A>T	ENST00000395412.1	+	10	1789	c.1070A>T	c.(1069-1071)cAa>cTa	p.Q357L	CSNK1G3_ENST00000512718.3_Missense_Mutation_p.Q282L|CSNK1G3_ENST00000360683.2_Missense_Mutation_p.Q357L|CSNK1G3_ENST00000521364.1_Missense_Mutation_p.Q357L|CSNK1G3_ENST00000511130.2_Missense_Mutation_p.Q245L|CSNK1G3_ENST00000510842.2_Missense_Mutation_p.Q358L|CSNK1G3_ENST00000395411.1_Missense_Mutation_p.Q357L|CSNK1G3_ENST00000361991.2_Missense_Mutation_p.Q357L|CSNK1G3_ENST00000345990.4_Missense_Mutation_p.Q357L	NM_001044723.1	NP_001038188.1	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3	357					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(1)	15		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		GATAAGATGCAACAATCCAAA	0.383000													7	32					0	0	0.00307968	0	0
CD1A	909	broad.mit.edu	37	1	158225793	158225793	+	Splice_Site	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:158225793G>C	ENST00000289429.5	+	3	858		c.e3-1			NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule						antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CATAACCCCAGATCCTTTTGA	0.423000													18	75					0	0	0.00121646	0	0
EPS15	2060	broad.mit.edu	37	1	51869091	51869091	+	Splice_Site	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:51869091C>A	ENST00000371733.3	-	17	1887	c.1791_splice	c.e17+1	p.E597_splice	EPS15_ENST00000396122.4_Splice_Site_p.E274_splice|EPS15_ENST00000371730.2_Splice_Site_p.E463_splice	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	597					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						CATTTTTTACCTCTTTTGAAT	0.358000			T	MLL	ALL								7	52					2.0095e-06	7.30869e-06	0.00198382	1	0
XIST	7503	broad.mit.edu	37	X	73061259	73061259	+	RNA	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:73061259G>A	ENST00000429829.1	-	0	11329					NR_001564.2																						AGCTGTCCGAGGAGCTAGTAG	0.393000													10	39					0	0	0.000442599	0	0
C7	730	broad.mit.edu	37	5	40947812	40947812	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:40947812C>T	ENST00000313164.9	+	8	1206	c.847C>T	c.(847-849)Ctc>Ttc	p.L283F		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	283	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				GCTTTCCCACCTCCCCTCTCT	0.448000													18	31					0	0	0.00074312	0	0
WDPCP	51057	broad.mit.edu	37	2	63631262	63631262	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:63631262C>G	ENST00000409120.1	-	4	4330	c.780G>C	c.(778-780)aaG>aaC	p.K260N	WDPCP_ENST00000409199.1_Missense_Mutation_p.K260N|WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000398544.3_Missense_Mutation_p.K293N|WDPCP_ENST00000409562.3_Missense_Mutation_p.K452N|WDPCP_ENST00000272321.7_Missense_Mutation_p.K452N			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	452					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						TACCTTCACCCTTCTGAGAAA	0.433000													15	72					0	0	0.00400662	0	0
ENDOD1	23052	broad.mit.edu	37	11	94862474	94862474	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:94862474C>T	ENST00000278505.4	+	2	1352	c.1234C>T	c.(1234-1236)Ctc>Ttc	p.L412F		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	412						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				CATCAGGGCTCTCCTCCGGAT	0.552000													12	69					0	0	0.000978159	0	0
YME1L1	10730	broad.mit.edu	37	10	27409370	27409370	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:27409370C>A	ENST00000326799.3	-	14	1724	c.1576G>T	c.(1576-1578)Gat>Tat	p.D526Y	YME1L1_ENST00000376016.3_Missense_Mutation_p.D469Y|YME1L1_ENST00000375972.3_Missense_Mutation_p.D436Y	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	526					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TTACATTGATCAAACTTTATT	0.333000													11	40					9.70103e-10	4.19675e-09	0.000673444	1	0
PRKG2	5593	broad.mit.edu	37	4	82096055	82096055	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:82096055G>T	ENST00000395578.1	-	3	636	c.520C>A	c.(520-522)Cct>Act	p.P174T	PRKG2_ENST00000264399.1_Missense_Mutation_p.P174T|PRKG2_ENST00000418486.2_Missense_Mutation_p.P174T|RP11-100N20.1_ENST00000512502.1_RNA|RP11-100N20.1_ENST00000505175.1_RNA			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	174					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						ATCTGCTGAGGATCCAGTCTT	0.363000													31	124					1.06801e-11	5.00923e-11	0.00178596	1	0
ABCA12	26154	broad.mit.edu	37	2	215884272	215884272	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:215884272A>T	ENST00000272895.7	-	12	1755	c.1536T>A	c.(1534-1536)aaT>aaA	p.N512K	ABCA12_ENST00000389661.4_Missense_Mutation_p.N194K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	512					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACTGATCCATATTTAAATTAA	0.343000													18	75					0	0	0.00152264	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455447	84455447	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:84455447G>T	ENST00000377084.2	-	1	1081	c.196C>A	c.(196-198)Cat>Aat	p.H66N		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	66						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAATTGCCATGCAGAAATAAA	0.438000													13	65					1.61879e-10	7.18145e-10	0.00136819	1	0
NCAN	1463	broad.mit.edu	37	19	19345853	19345853	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:19345853T>A	ENST00000252575.5	+	10	3241	c.3198T>A	c.(3196-3198)aaT>aaA	p.N1066K	NCAN_ENST00000538881.1_Missense_Mutation_p.N517K	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1066	EGF-like 2; calcium-binding (Potential).				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			ATGAGGTCAATGGCTTTGTCT	0.517000													5	45					0	0	0.000602214	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40458862	40458862	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:40458862C>T	ENST00000378438.4	+	7	765	c.607C>T	c.(607-609)Cta>Tta	p.L203L	ATP6AP2_ENST00000535539.1_Silent_p.L171L|ATP6AP2_ENST00000535777.1_Silent_p.L125L|ATP6AP2_ENST00000544975.1_Silent_p.L127L|ATP6AP2_ENST00000486558.1_3'UTR	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2	203					angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						TCATAAGCATCTAGCCAAGGA	0.408000													6	71					0	0	0.00307968	0	0
CDH2	1000	broad.mit.edu	37	18	25583076	25583076	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:25583076C>A	ENST00000269141.3	-	7	1328	c.905G>T	c.(904-906)gGg>gTg	p.G302V	CDH2_ENST00000399380.3_Missense_Mutation_p.G271V	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	302	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCTCAACATCCCATTGAGGGC	0.458000													21	41					0.000175454	0.000567071	0.00152264	1	0
ZNF804A	91752	broad.mit.edu	37	2	185800553	185800553	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185800553G>C	ENST00000302277.6	+	4	1024	c.430G>C	c.(430-432)Gtg>Ctg	p.V144L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	144						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AACTGTTACTGTGAGAGAAAA	0.353000													19	76					0	0	0.00278032	0	0
XAGE5	170627	broad.mit.edu	37	X	52844149	52844149	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:52844149C>A	ENST00000351072.1	+	4	278	c.212C>A	c.(211-213)tCt>tAt	p.S71Y	XAGE5_ENST00000445860.2_3'UTR|XAGE5_ENST00000375503.3_3'UTR|XAGE5_ENST00000375501.1_Missense_Mutation_p.S71Y|XAGE5_ENST00000425386.1_Missense_Mutation_p.S71Y			Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	71										endometrium(1)|large_intestine(1)|lung(5)|ovary(1)	8						CAGGAGCTGTCTCAGTCAAAG	0.443000													10	44					0.000442599	0.00138238	0.000442599	1	0
SGIP1	84251	broad.mit.edu	37	1	67147941	67147941	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:67147941G>C	ENST00000371037.4	+	15	1281	c.1204G>C	c.(1204-1206)Gat>Cat	p.D402H	SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Missense_Mutation_p.D406H	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	402	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						ATCTCCTAAAGATTTTGGGTT	0.512000													16	84					0	0	0.00400662	0	0
OR2L2	26246	broad.mit.edu	37	1	248201833	248201833	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248201833C>G	ENST00000366479.2	+	1	360	c.264C>G	c.(262-264)aaC>aaG	p.N88K	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			tgtatggaaacaagtctatct	0.413000													46	221					0	0	0.0025221	0	0
DEK	7913	broad.mit.edu	37	6	18258558	18258558	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:18258558C>G	ENST00000397239.3	-	3	671	c.224G>C	c.(223-225)aGa>aCa	p.R75T	DEK_ENST00000244776.7_Intron	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	75					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			AAATGGCTCTCTCTGTAAGGA	0.353000			T	NUP214	AML								12	93					0	0	0.00136819	0	0
PLSCR2	57047	broad.mit.edu	37	3	146176237	146176237	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:146176237C>A	ENST00000497985.1	-	5	719	c.280G>T	c.(280-282)Gat>Tat	p.D94Y	PLSCR2_ENST00000336685.2_Missense_Mutation_p.D21Y	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	21					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						AGTATCATATCTATCTATTAT	0.234000													4	14					1.23904e-05	4.26169e-05	0.000602214	1	0
KDM5B	10765	broad.mit.edu	37	1	202711841	202711841	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:202711841C>G	ENST00000367265.3	-	17	3580	c.2416G>C	c.(2416-2418)Gat>Cat	p.D806H	KDM5B_ENST00000367264.2_Missense_Mutation_p.D842H	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	806					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TTCTCTGCATCCTGTGTGACT	0.458000													25	89					0	0	0.00395357	0	0
PHF20L1	51105	broad.mit.edu	37	8	133837560	133837560	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:133837560A>T	ENST00000395386.2	+	14	1987	c.1688A>T	c.(1687-1689)cAc>cTc	p.H563L	PHF20L1_ENST00000315808.10_3'UTR|PHF20L1_ENST00000395383.1_3'UTR|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000395390.2_Missense_Mutation_p.H538L	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	563	Lys-rich.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			gacaaagaTCACTACAGACCA	0.313000													7	23					0	0	0.00198382	0	0
TTN	7273	broad.mit.edu	37	2	179644746	179644746	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179644746C>A	ENST00000589042.1	-	22	3934	c.3710G>T	c.(3709-3711)aGa>aTa	p.R1237I	TTN_ENST00000460472.2_Missense_Mutation_p.R1191I|TTN_ENST00000359218.5_Missense_Mutation_p.R1191I|TTN_ENST00000591111.1_Missense_Mutation_p.R1237I|TTN_ENST00000360870.5_Missense_Mutation_p.R1237I|TTN_ENST00000342992.6_Missense_Mutation_p.R1237I|TTN_ENST00000342175.6_Missense_Mutation_p.R1191I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1237							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACATAAGTTCTGACCACTAC	0.303000													15	75					3.45872e-05	0.000117512	0.00400662	1	0
TLR4	7099	broad.mit.edu	37	9	120470921	120470921	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:120470921C>T	ENST00000355622.6	+	2	275	c.174C>T	c.(172-174)aaC>aaT	p.N58N	TLR4_ENST00000472304.1_Intron|TLR4_ENST00000394487.4_Silent_p.N18N	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	58					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CAACCAAGAACCTGGACCTGA	0.443000													19	127					0	0	0.00152264	0	0
OR7G2	390882	broad.mit.edu	37	19	9213468	9213468	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9213468G>A	ENST00000305456.2	-	1	514	c.515C>T	c.(514-516)aCt>aTt	p.T172I		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CACAACACTAGTCAACAGAGA	0.522000													7	46					0	0	0.00448238	0	0
APOB	338	broad.mit.edu	37	2	21225982	21225982	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:21225982C>T	ENST00000233242.1	-	29	12439	c.12312G>A	c.(12310-12312)ctG>ctA	p.L4104L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4104					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATTTCTTCTCAGCTTTGAAG	0.488000													27	120					0	0	0.001512	0	0
AGT	183	broad.mit.edu	37	1	230841707	230841707	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:230841707G>T	ENST00000366667.4	-	3	1310	c.1096C>A	c.(1096-1098)Ctc>Atc	p.L366I		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	366					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ATCCAGTTGAGGGAGTTTTGC	0.607000													20	75					4.35082e-09	1.82551e-08	0.00152264	1	0
PICALM	8301	broad.mit.edu	37	11	85692255	85692255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:85692255G>A	ENST00000526033.1	-	17	1991	c.1675C>T	c.(1675-1677)Caa>Taa	p.Q559*	PICALM_ENST00000393346.3_Nonsense_Mutation_p.Q566*|PICALM_ENST00000356360.5_Nonsense_Mutation_p.Q566*|PICALM_ENST00000532317.1_Nonsense_Mutation_p.Q516*|PICALM_ENST00000528398.1_Nonsense_Mutation_p.Q465*	NM_001206946.1|NM_007166.3	NP_001193875.1|NP_009097.2	Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	566					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				TCACCTGGTTGACTCCAATTT	0.353000			T	"""MLLT10, MLL"""	"""TALL, AML, """								17	53					0	0	0.00074312	0	0
TEK	7010	broad.mit.edu	37	9	27185554	27185554	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:27185554C>A	ENST00000380036.4	+	9	1696	c.1254C>A	c.(1252-1254)gaC>gaA	p.D418E	TEK_ENST00000406359.4_Missense_Mutation_p.D375E|TEK_ENST00000519097.1_Missense_Mutation_p.D271E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	418	Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCCCCCCTGACTCAGGAGTTT	0.428000													18	63					1.15919e-05	4.00682e-05	0.00121646	1	0
GSTA1	2938	broad.mit.edu	37	6	52657758	52657758	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:52657758G>T	ENST00000334575.5	-	6	597	c.442C>A	c.(442-444)Ctt>Att	p.L148I	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	148	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	TTGCCAACAAGGTAGTCTTGT	0.527000													28	73					1.16021e-09	4.98818e-09	0.00127121	1	0
VCAN	1462	broad.mit.edu	37	5	82836404	82836404	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:82836404G>C	ENST00000265077.3	+	8	8147	c.7582G>C	c.(7582-7584)Gag>Cag	p.E2528Q	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.E1541Q|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2528	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGGGAATTCGAGGATTCCAC	0.408000													12	50					0	0	0.000978159	0	0
TLR8	51311	broad.mit.edu	37	X	12939365	12939365	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:12939365A>T	ENST00000218032.6	+	2	2293	c.2206A>T	c.(2206-2208)Agt>Tgt	p.S736C	TLR8_ENST00000311912.5_Missense_Mutation_p.S754C	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	736					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTCTGAAGTCAGTAGTCTGAA	0.413000													15	127					0	0	0.00316338	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158014053	158014053	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:158014053G>C	ENST00000359775.5	+	3	1329	c.440G>C	c.(439-441)cGc>cCc	p.R147P	ZDHHC14_ENST00000414563.2_Missense_Mutation_p.R147P|ZDHHC14_ENST00000341375.8_3'UTR			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	147						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGGGGGTACCGCCCGCCTCCC	0.567000													16	38					0	0	0.00400662	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465222	70465222	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:70465222G>C	ENST00000373998.1	-	18	3635	c.2938C>G	c.(2938-2940)Cct>Gct	p.P980A	ZMYM3_ENST00000314425.5_Missense_Mutation_p.P992A|ZMYM3_ENST00000373984.3_Missense_Mutation_p.P994A|ZMYM3_ENST00000373988.1_Missense_Mutation_p.P994A|ZMYM3_ENST00000353904.2_Missense_Mutation_p.P992A|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	992					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TCTTGCCCAGGCTCATCCAAG	0.547000													4	25					0	0	0.00024832	0	0
LGR5	8549	broad.mit.edu	37	12	71898402	71898402	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:71898402G>T	ENST00000266674.5	+	2	532	c.221G>T	c.(220-222)aGt>aTt	p.S74I	LGR5_ENST00000536515.1_Missense_Mutation_p.S74I|LGR5_ENST00000540815.2_Missense_Mutation_p.S74I			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	74						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						AGAGACCTCAGTATGAACAAC	0.493000													43	193					2.51966e-14	1.26255e-13	0.00361006	1	0
BZRAP1	9256	broad.mit.edu	37	17	56400700	56400700	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:56400700C>A	ENST00000355701.3	-	7	1933	c.1063G>T	c.(1063-1065)Gag>Tag	p.E355*	BZRAP1_ENST00000268893.6_Nonsense_Mutation_p.E295*|BZRAP1_ENST00000343736.4_Nonsense_Mutation_p.E355*	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	355						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTTCCTGCTCCAGGCTCTCG	0.607000													21	90					6.44725e-10	2.79783e-09	0.00229938	1	0
PSG7	5676	broad.mit.edu	37	19	43430685	43430685	+	RNA	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43430685G>T	ENST00000406070.2	-	0	989				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CGTGACACTGGGTAGAATGAG	0.502000													41	187					1.41504e-22	7.58132e-22	0.00285205	1	0
TSHR	7253	broad.mit.edu	37	14	81610628	81610628	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:81610628T>A	ENST00000541158.2	+	11	2548	c.2226T>A	c.(2224-2226)atT>atA	p.I742I	RP11-114N19.3_ENST00000557775.1_RNA|TSHR_ENST00000298171.2_Silent_p.I742I			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	742					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	ATGAACTGATTGAAAACTCCC	0.438000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						38	67					0	0	0.00195071	0	0
RPH3A	22895	broad.mit.edu	37	12	113319615	113319615	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:113319615C>A	ENST00000389385.4	+	15	1787	c.1290C>A	c.(1288-1290)ccC>ccA	p.P430P	RPH3A_ENST00000551052.1_Silent_p.P426P|RPH3A_ENST00000447659.2_Silent_p.P381P|RPH3A_ENST00000415485.3_Silent_p.P430P|RPH3A_ENST00000543106.2_Silent_p.P430P|RPH3A_ENST00000420983.2_Silent_p.P430P|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000548866.1_Silent_p.P381P	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	430	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGGCTGATCCCTACGTTAAGC	0.607000													14	49					1.3612e-06	5.04297e-06	0.00316338	1	0
ACADM	34	broad.mit.edu	37	1	76211563	76211563	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:76211563delG	ENST00000370841.4	+	8	1109	c.672delG	c.(670-672)gtfs	p.V224fs	ACADM_ENST00000541113.1_Frame_Shift_Del_p.V188fs|ACADM_ENST00000543667.1_Frame_Shift_Del_p.V35fs|ACADM_ENST00000370834.5_Frame_Shift_Del_p.V257fs|ACADM_ENST00000420607.2_Frame_Shift_Del_p.V228fs	NM_000016.4|NM_001127328.1	NP_000007.1|NP_001120800.1	P11310	ACADM_HUMAN	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	224					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	18						GATTCATTGTGGAAGCAGATA	0.343													13	97	---	---	---	---					
RBM34	23029	broad.mit.edu	37	1	235324345	235324345	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:235324345delC	ENST00000408888.3	-	2	321	c.91delG	c.(91-93)aafs	p.E31fs	RBM34_ENST00000366606.3_Frame_Shift_Del_p.E26fs			P42696	RBM34_HUMAN	RNA binding motif protein 34	31						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CTGTAGTCTTCCGGCGGACTC	0.607													12	18	---	---	---	---					
OR2B11	127623	broad.mit.edu	37	1	247614468	247614468	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:247614468delC	ENST00000318749.6	-	1	840	c.817delG	c.(817-819)agfs	p.E273fs		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTGCCCTGCTCTTGGGAGTAG	0.493													17	126	---	---	---	---					
LRP2	4036	broad.mit.edu	37	2	170134449	170134450	+	Frame_Shift_Ins	INS	-	-	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:170134449_170134450insA	ENST00000263816.3	-	13	1862_1863	c.1577_1578insT	c.(1576-1578)ttcfs	p.F526fs	LRP2_ENST00000443831.1_Intron	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	526					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCCAATCTGAGAAAAATAAATA	0.391													16	73	---	---	---	---					
ZNF717	100131827	broad.mit.edu	37	3	75790810	75790811	+	Frame_Shift_Ins	INS	-	-	T	rs76346895		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:75790810_75790811insT	ENST00000422325.1	-	3	456_457	c.134_135insA	c.(133-135)actfs	p.T45fs	ZNF717_ENST00000477374.1_Frame_Shift_Ins_p.T45fs|ZNF717_ENST00000491507.1_5'UTR|ZNF717_ENST00000478296.1_5'UTR|ZNF717_ENST00000400845.3_Frame_Shift_Ins_p.T38fs	NM_001128223.1	NP_001121695.1	C9JSV9	C9JSV9_HUMAN	zinc finger protein 717	45					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			autonomic_ganglia(6)|endometrium(3)|lung(2)|ovary(1)|stomach(7)	19						CCCTGTACAGGGTCCTCTGAGC	0.510													3	5	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:12316384_12316389delCTCCTA	ENST00000256186.2	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)cca>c	p.PPT469del		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	469	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding	p.T471delT(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.573													4	2	---	---	---	---					
OR5D14	219436	broad.mit.edu	37	11	55563619	55563619	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55563619delC	ENST00000335605.1	+	1	588	c.588delC	c.(586-588)atfs	p.I196fs		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				ATATACTCATCCCCCACCTGC	0.418													19	181	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:49087434_49087436delATG	ENST00000261900.3	-	9	1783_1785	c.1561_1563delCAT	c.(1561-1563)del	p.H521del		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGGTGATTATGATGATGATGA	0.443													7	480	---	---	---	---					
PABPC3	5042	broad.mit.edu	37	13	25671273	25671273	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:25671273delG	ENST00000281589.3	+	1	974	c.937delG	c.(937-939)cgfs	p.A313fs		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	313	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCTCCGGAAAGCGTTTTCTCC	0.408													7	292	---	---	---	---					
NID2	22795	broad.mit.edu	37	14	52526841	52526841	+	Splice_Site	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:52526841delC	ENST00000216286.5	-	3	767		c.e3+1		NID2_ENST00000541773.1_Splice_Site	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)							basement membrane	calcium ion binding|collagen binding	p.?(1)		NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ATGTTACTTACTGATAGAGAT	0.418													7	35	---	---	---	---					
KIF2B	84643	broad.mit.edu	37	17	51901016	51901016	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:51901016delC	ENST00000268919.4	+	1	778	c.622delC	c.(622-624)ccfs	p.P209fs		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	209					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AGTCCTGGAGCCCCCGCAAGA	0.552													8	26	---	---	---	---					
CARD8	22900	broad.mit.edu	37	19	48733883	48733883	+	Frame_Shift_Del	DEL	G	G	-	rs148180647		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:48733883delG	ENST00000391898.3	-	7	889	c.847delC	c.(847-849)ggfs	p.R283fs	CARD8_ENST00000520753.1_Frame_Shift_Del_p.R283fs|CARD8_ENST00000520153.1_Frame_Shift_Del_p.R233fs|CARD8_ENST00000447740.2_Frame_Shift_Del_p.R233fs|CARD8_ENST00000520015.1_Frame_Shift_Del_p.R283fs|CARD8_ENST00000359009.4_Frame_Shift_Del_p.R177fs|CARD8_ENST00000357778.5_Frame_Shift_Del_p.R8fs|CARD8_ENST00000519940.1_Frame_Shift_Del_p.R283fs|CARD8_ENST00000521613.1_Frame_Shift_Del_p.R233fs|ZNF114_ENST00000597695.1_Intron	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	177					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		GGCTCCACCCGGGCTGGATGC	0.577													11	75	---	---	---	---					
TMPRSS15	5651	broad.mit.edu	37	21	19770237	19770238	+	Frame_Shift_Ins	INS	-	-	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:19770237_19770238insT	ENST00000284885.3	-	3	335_336	c.302_303insA	c.(301-303)actfs	p.T101fs		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	101	SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CATTCTTCAGATTGCTTGATAG	0.243													7	28	---	---	---	---					
