Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TBC1D9B	23061	broad.mit.edu	37	5	179321595	179321595	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr5:179321595T>C	ENST00000356834.3	-	4	405	c.368A>G	c.(367-369)aAc>aGc	p.N123S	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.N123S	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	123						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGTTCTTGTTCTCTTCTGC	0.602000													4	64					0	0	0.000602214	0	0
ZFP57	346171	broad.mit.edu	37	6	29640722	29640722	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr6:29640722C>A	ENST00000376883.1	-	6	1517	c.1106G>T	c.(1105-1107)tGt>tTt	p.C369F	ZFP57_ENST00000488757.1_Missense_Mutation_p.C389F|ZFP57_ENST00000376881.3_Missense_Mutation_p.C369F			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	305					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						AGTCAAAGAACAATGGGGGCA	0.517000													79	278					1.7488e-33	1.04928e-32	0.000781405	1	0
WRAP53	55135	broad.mit.edu	37	17	7593016	7593016	+	Silent	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr17:7593016A>G	ENST00000316024.5	+	3	2987	c.639A>G	c.(637-639)gaA>gaG	p.E213E	WRAP53_ENST00000396463.2_Silent_p.E213E|WRAP53_ENST00000534050.1_Silent_p.E180E|WRAP53_ENST00000457584.2_Silent_p.E213E|WRAP53_ENST00000431639.2_Silent_p.E213E			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	213					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						AATATGCAGAAATGGTAAGGA	0.463000													10	36					0	0	0.000442599	0	0
CEPT1	10390	broad.mit.edu	37	1	111726191	111726191	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr1:111726191T>G	ENST00000545121.1	+	8	1321	c.1113T>G	c.(1111-1113)atT>atG	p.I371M	CEPT1_ENST00000357172.4_Missense_Mutation_p.I371M|CEPT1_ENST00000467362.1_3'UTR	NM_001007794.1	NP_001007795.1	Q9Y6K0	CEPT1_HUMAN	choline/ethanolamine phosphotransferase 1	371						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	8		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	ATGAATATATTGTACTTTGGA	0.363000													8	82					0	0	0.000274275	0	0
PKDREJ	10343	broad.mit.edu	37	22	46658152	46658152	+	Silent	SNP	C	C	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr22:46658152C>G	ENST00000253255.5	-	1	1067	c.1068G>C	c.(1066-1068)ctG>ctC	p.L356L		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	356	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TGGACCCGTCCAGAATCAGCT	0.557000													17	104					0	0	0.000958276	0	0
GLI2	2736	broad.mit.edu	37	2	121736058	121736058	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr2:121736058C>T	ENST00000452319.1	+	10	1477	c.1417C>T	c.(1417-1419)Cgc>Tgc	p.R473C	GLI2_ENST00000314490.11_Missense_Mutation_p.R145C|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.R473C			P10070	GLI2_HUMAN	GLI family zinc finger 2	473					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GTTTGTGTGCCGCTGGCAGGC	0.627000													7	184					0	0	0.000978159	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													5	75					0	0	0.000602214	0	0
PRODH2	58510	broad.mit.edu	37	19	36297459	36297459	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr19:36297459G>A	ENST00000301175.3	-	8	1119	c.1102C>T	c.(1102-1104)Cac>Tac	p.H368Y		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	368					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGGCCCTGTGCGCAGCCTCT	0.637000													8	203					0	0	0.000274275	0	0
CIRBP	1153	broad.mit.edu	37	19	1272056	1272056	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr19:1272056T>C	ENST00000444172.2	+	5	483	c.349T>C	c.(349-351)Tca>Cca	p.S117P	CIRBP_ENST00000589660.1_Intron|CIRBP_ENST00000586472.1_Intron|CIRBP_ENST00000413636.2_Missense_Mutation_p.S136P|CIRBP_ENST00000588230.1_Missense_Mutation_p.S170P|CIRBP_ENST00000589686.1_Intron|CIRBP_ENST00000587323.1_Missense_Mutation_p.S170P|CIRBP_ENST00000588030.1_Intron|CIRBP_ENST00000587896.1_Missense_Mutation_p.S170P|CIRBP_ENST00000591935.1_Intron|CIRBP_ENST00000585630.1_Intron|CIRBP_ENST00000589235.1_Intron|CIRBP_ENST00000320936.5_Intron|CIRBP_ENST00000588090.1_Intron|CIRBP_ENST00000586773.1_Intron|CIRBP_ENST00000589710.1_Missense_Mutation_p.S170P			Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	169	Gly-rich.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity			endometrium(1)|large_intestine(1)|lung(3)	5		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTACGGTAAGTCACACTCCGA	0.587000													3	99					0	0	0.00024832	0	0
CD33	945	broad.mit.edu	37	19	51729239	51729239	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr19:51729239C>G	ENST00000436584.2	+	2	273	c.218C>G	c.(217-219)aCc>aGc	p.T73S	CD33_ENST00000391796.3_Missense_Mutation_p.T200S|CD33_ENST00000262262.4_Missense_Mutation_p.T200S|CD33_ENST00000421133.2_Missense_Mutation_p.T73S			P20138	CD33_HUMAN	CD33 molecule	200	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTCATAATCACCCCACGGCCC	0.617000													4	87					0	0	0.00024832	0	0
FRG1B	284802	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													4	57					0	0	0.00024832	0	0
GPR6	2830	broad.mit.edu	37	6	110300677	110300677	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr6:110300677C>T	ENST00000414000.2	+	3	646	c.407C>T	c.(406-408)gCg>gTg	p.A136V	GPR6_ENST00000275169.3_Missense_Mutation_p.A121V			P46095	GPR6_HUMAN	G protein-coupled receptor 6	121						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GACCTGTTGGCGGGCTGTGGC	0.652000													30	116					0	0	0.00178596	0	0
HERC2P2	400322	broad.mit.edu	37	15	23312122	23312122	+	RNA	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr15:23312122C>T	ENST00000560464.1	-	0	3266																											CACTGCACCGCTCTTCACCAG	0.617000													7	10					0	0	0.000274275	0	0
ASB10	136371	broad.mit.edu	37	7	150878359	150878359	+	Silent	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:150878359G>A	ENST00000422024.1	-	3	1031	c.906C>T	c.(904-906)gaC>gaT	p.D302D	ASB10_ENST00000377867.3_Silent_p.D242D|ASB10_ENST00000434669.1_Silent_p.D302D|ASB10_ENST00000275838.1_Silent_p.D257D|ASB10_ENST00000420175.2_Silent_p.D257D	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	257					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCAGCGGACGTCACAGGCAG	0.652000													6	35					0	0	8.12818e-05	0	0
ZNF212	7988	broad.mit.edu	37	7	148947288	148947288	+	Silent	SNP	C	C	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:148947288C>G	ENST00000335870.2	+	2	191	c.63C>G	c.(61-63)tcC>tcG	p.S21S		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TAACTTCTTCCACACTTCCTT	0.458000													8	75					0	0	0.000157383	0	0
SEMA3E	9723	broad.mit.edu	37	7	83119449	83119449	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:83119449A>T	ENST00000307792.3	-	2	724	c.257T>A	c.(256-258)aTc>aAc	p.I86N	SEMA3E_ENST00000427262.1_Missense_Mutation_p.I26N	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	86	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GCCGTCACTGATTCTCTCCAA	0.388000													3	19					0	0	0.00024832	0	0
LZTR1	8216	broad.mit.edu	37	22	21340175	21340175	+	Silent	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr22:21340175C>T	ENST00000215739.8	+	3	668	c.309C>T	c.(307-309)tgC>tgT	p.C103C	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Intron	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	103					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGAAAGACTGCTCCTGGTGCA	0.592000													8	45					0	0	0.000442599	0	0
DSC3	1825	broad.mit.edu	37	18	28604352	28604352	+	Silent	SNP	T	T	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr18:28604352T>G	ENST00000434452.1	-	6	892	c.738A>C	c.(736-738)gcA>gcC	p.A246A	DSC3_ENST00000360428.4_Silent_p.A246A	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	246	Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AATTATAAATTGCTTCTGTGA	0.368000													6	33					0	0	0.000157383	0	0
NSF	4905	broad.mit.edu	37	17	44788352	44788352	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr17:44788352T>G	ENST00000398238.4	+	14	1601	c.1494T>G	c.(1492-1494)gaT>gaG	p.D498E	NSF_ENST00000225282.8_Missense_Mutation_p.D404E|NSF_ENST00000575068.1_Missense_Mutation_p.D493E	NM_006178.3	NP_006169.2	P46459	NSF_HUMAN	N-ethylmaleimide-sensitive factor	498					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			kidney(2)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		ACCAAGAAGATTATGCAAGTT	0.398000													5	79					0	0	0.000602214	0	0
SLC17A8	246213	broad.mit.edu	37	12	100811839	100811839	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr12:100811839C>T	ENST00000323346.5	+	11	1643	c.1330C>T	c.(1330-1332)Cgc>Tgc	p.R444C	SLC17A8_ENST00000392989.3_Missense_Mutation_p.R394C|SLC17A8_ENST00000552697.1_3'UTR	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	444					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						CATTGCCCCACGCTATGCCAG	0.458000													9	120					0	0	0.000978159	0	0
LETM1	3954	broad.mit.edu	37	4	1843351	1843351	+	Missense_Mutation	SNP	C	C	T	rs138076114		TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr4:1843351C>T	ENST00000302787.2	-	3	613	c.317G>A	c.(316-318)cGt>cAt	p.R106H		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	106					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			GTGCCAGCCACGCACAGGAAG	0.597000													10	94					0	0	0.000673444	0	0
SACS	26278	broad.mit.edu	37	13	23910594	23910594	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr13:23910594A>T	ENST00000382298.3	-	10	8009	c.7421T>A	c.(7420-7422)aTa>aAa	p.I2474K	SACS_ENST00000382292.3_Missense_Mutation_p.I2474K|SACS_ENST00000402364.1_Missense_Mutation_p.I1724K	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2474					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTTACTTTTATCCAAGGGCA	0.378000													14	81					0	0	0.000219431	0	0
AHNAK	79026	broad.mit.edu	37	11	62295599	62295599	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr11:62295599T>C	ENST00000378024.4	-	5	6564	c.6290A>G	c.(6289-6291)gAa>gGa	p.E2097G	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2097					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CAGCTTCCCTTCTGGACCTTC	0.532000													5	329					0	0	0.000602214	0	0
FRG1B	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D|FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													4	78					0	0	0.000602214	0	0
OR51A7	119687	broad.mit.edu	37	11	4929446	4929446	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr11:4929446C>T	ENST00000359350.4	+	1	847	c.847C>T	c.(847-849)Ccg>Tcg	p.P283S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGTTGGTGCCGCCCCTTAT	0.458000													21	123					0	0	0.000295444	0	0
BPIFB2	80341	broad.mit.edu	37	20	31604887	31604887	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr20:31604887G>A	ENST00000170150.3	+	7	751	c.556G>A	c.(556-558)Gtc>Atc	p.V186I		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	186						extracellular region	lipid binding										GGGTGTCAATGTCCACCTGGG	0.622000													27	125					0	0	0.00106085	0	0
SLC25A34	284723	broad.mit.edu	37	1	16065758	16065758	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr1:16065758A>G	ENST00000294454.5	+	5	853	c.772A>G	c.(772-774)Atc>Gtc	p.I258V	SLC25A34_ENST00000489568.1_3'UTR	NM_207348.1	NP_997231.1	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	258					transport	integral to membrane|mitochondrial inner membrane				NS(1)|breast(1)|endometrium(3)|large_intestine(1)|lung(2)|skin(1)	9		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CATGGTGAAGATCTGGCGGCA	0.657000													11	58					0	0	0.000978159	0	0
SETD5	55209	broad.mit.edu	37	3	9477424	9477424	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr3:9477424G>C	ENST00000402466.1	+	7	836	c.68G>C	c.(67-69)aGt>aCt	p.S23T	SETD5_ENST00000302463.6_Missense_Mutation_p.S23T|SETD5_ENST00000406341.1_Missense_Mutation_p.S134T|SETD5_ENST00000402198.1_Missense_Mutation_p.S134T|SETD5_ENST00000407969.1_Missense_Mutation_p.S153T			Q9C0A6	SETD5_HUMAN	SET domain containing 5	134										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GGGGATAGCAGTGCAACAGAA	0.423000													5	12					0	0	0.00116845	0	0
KCNH3	23416	broad.mit.edu	37	12	49950989	49950989	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr12:49950989C>T	ENST00000257981.6	+	14	2859	c.2599C>T	c.(2599-2601)Cat>Tat	p.H867Y		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	867					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						CACTGTTCCCCATGGGCCCAG	0.627000													17	49					0	0	0.000566183	0	0
AFF3	3899	broad.mit.edu	37	2	100175384	100175384	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr2:100175384T>C	ENST00000317233.4	-	21	3473	c.3238A>G	c.(3238-3240)Agg>Ggg	p.R1080G	AFF3_ENST00000409236.1_Missense_Mutation_p.R1080G|AFF3_ENST00000409579.1_Missense_Mutation_p.R1105G|AFF3_ENST00000356421.2_Missense_Mutation_p.R1105G	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1080					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GCGTGGTCCCTTTTGAGTCGA	0.483000											OREG0014830	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	55					0	0	0.00024832	0	0
PDILT	204474	broad.mit.edu	37	16	20384335	20384335	+	Splice_Site	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr16:20384335T>C	ENST00000302451.4	-	6	1039	c.792_splice	c.e6+1	p.E264_splice		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	264					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CTCACTGACCTCAGTGTTGTA	0.443000													6	98					0	0	0.00116845	0	0
GIGYF2	26058	broad.mit.edu	37	2	233715054	233715054	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr2:233715054A>G	ENST00000373566.3	+	29	4030	c.3833A>G	c.(3832-3834)gAg>gGg	p.E1278G	GIGYF2_ENST00000409451.3_Missense_Mutation_p.E1277G|GIGYF2_ENST00000409196.3_Missense_Mutation_p.E1250G|GIGYF2_ENST00000373563.4_Missense_Mutation_p.E1256G|GIGYF2_ENST00000409480.1_Missense_Mutation_p.E1278G|GIGYF2_ENST00000409547.1_Missense_Mutation_p.E1256G			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1256					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TCCAATTTTGAGGCTGTGCAG	0.463000													3	70					0	0	0.00024832	0	0
HCN4	10021	broad.mit.edu	37	15	73617439	73617439	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr15:73617439C>T	ENST00000261917.3	-	6	2828	c.1835G>A	c.(1834-1836)cGt>cAt	p.R612H		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	612					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GACCTCGAAACGCAGCTTGGT	0.552000													15	96					0	0	0.000566183	0	0
KCNB2	9312	broad.mit.edu	37	8	73848601	73848601	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr8:73848601G>C	ENST00000523207.1	+	3	1599	c.1011G>C	c.(1009-1011)ttG>ttC	p.L337F		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	337					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AATTGGGCTTGTTGATATTGT	0.473000													7	136					0	0	8.12818e-05	0	0
MALAT1	378938	broad.mit.edu	37	11	65273581	65273581	+	RNA	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr11:65273581A>G	ENST00000534336.1	+	0	8349					NR_002819.2																						AAAAAAAAAAAGCAAAAGATG	0.413000													5	42					0	0	0.000602214	0	0
SLIT3	6586	broad.mit.edu	37	5	168134994	168134994	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr5:168134994G>A	ENST00000519560.1	-	26	3250	c.2831C>T	c.(2830-2832)cCc>cTc	p.P944L	CTC-558O2.1_ENST00000521870.1_RNA|SLIT3_ENST00000404867.3_Missense_Mutation_p.P944L|SLIT3_ENST00000332966.8_Missense_Mutation_p.P951L|CTC-558O2.1_ENST00000522615.1_RNA	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	944	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTAGCTGTAGGGGCAGGCACA	0.612000													7	45					0	0	0.000157383	0	0
FAM178A	55719	broad.mit.edu	37	10	102697161	102697161	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr10:102697161G>A	ENST00000238961.3	+	10	2587	c.2439G>A	c.(2437-2439)atG>atA	p.M813I	FAM178A_ENST00000370269.3_Missense_Mutation_p.M813I	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	813																	TTTGACAGATGATGTCAGTTC	0.308000													8	158					0	0	0.000157383	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482229	142482229	+	RNA	SNP	T	T	A	rs145494190	by1000genomes	TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:142482229T>A	ENST00000603901.1	+	0	609					NR_001296.3													p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													5	67					0	0	0.000602214	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99968660	99968660	+	Silent	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr10:99968660C>T	ENST00000298999.3	+	5	1092	c.789C>T	c.(787-789)ggC>ggT	p.G263G	R3HCC1L_ENST00000370584.3_Silent_p.G263G|R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		GCAGCGGAGGCATCACCACTA	0.403000													5	64					0	0	0.00116845	0	0
FRG1B	284802	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P|FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													6	67					0	0	8.12818e-05	0	0
SDHAP1	255812	broad.mit.edu	37	3	195711423	195711423	+	RNA	SNP	A	A	G			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr3:195711423A>G	ENST00000427841.1	-	0	524					NR_003264.2																						CTCTTGTACTAGAAACAGACC	0.552000													5	45					0	0	0.000157383	0	0
FCAMR	83953	broad.mit.edu	37	1	207135834	207135834	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr1:207135834G>A	ENST00000324852.4	-	5	850	c.376C>T	c.(376-378)Cag>Tag	p.Q126*	FCAMR_ENST00000400962.3_Nonsense_Mutation_p.Q126*|FCAMR_ENST00000450945.2_Nonsense_Mutation_p.Q126*	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	81	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						TAATGGCACTGGATGGTGACA	0.557000													6	24					0	0	0.00116845	0	0
JADE2	23338	broad.mit.edu	37	5	133873705	133873705	+	Silent	SNP	A	A	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr5:133873705A>C	ENST00000395003.1	+	3	264	c.85A>C	c.(85-87)Aga>Cga	p.R29R	PHF15_ENST00000282605.4_Silent_p.R29R|PHF15_ENST00000402835.1_Silent_p.R29R|PHF15_ENST00000361895.2_Silent_p.R29R	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		29					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCCGCATCAAGATGCTCCAA	0.567000													10	66					0	0	0.000673444	0	0
MTIF2	4528	broad.mit.edu	37	2	55481241	55481241	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr2:55481241A>C	ENST00000394600.3	-	8	1336	c.600T>G	c.(598-600)ttT>ttG	p.F200L	MTIF2_ENST00000403721.1_Missense_Mutation_p.F200L|MTIF2_ENST00000263629.4_Missense_Mutation_p.F200L	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	200	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						GAGTTTTTCGAAATTTGTCAA	0.453000													5	58					0	0	0.000602214	0	0
TTN	7273	broad.mit.edu	37	2	179459289	179459289	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr2:179459289T>C	ENST00000589042.1	-	296	58156	c.57932A>G	c.(57931-57933)gAt>gGt	p.D19311G	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D16743G|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D10371G|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10246G|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D10438G|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D17670G	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17670	Fibronectin type-III 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACCCACCATCATACTTAGG	0.388000													3	116					0	0	6.4e-05	0	0
IL16	3603	broad.mit.edu	37	15	81575076	81575076	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr15:81575076C>T	ENST00000394660.2	+	9	1538	c.1178C>T	c.(1177-1179)gCg>gTg	p.A393V	IL16_ENST00000302987.4_Missense_Mutation_p.A393V	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	393	Interaction with GRIN2A.|PDZ 2.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GGATCCGTGGCGCACCTGGAC	0.557000													23	228					0	0	0.000878237	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													11	83					0	0	0.00136819	0	0
UNC13A	23025	broad.mit.edu	37	19	17750669	17750669	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr19:17750669T>C	ENST00000428389.2	-	24	3099	c.3100A>G	c.(3100-3102)Att>Gtt	p.I1034V	UNC13A_ENST00000550896.1_Missense_Mutation_p.I944V|UNC13A_ENST00000552293.1_Missense_Mutation_p.I946V|UNC13A_ENST00000551649.1_Missense_Mutation_p.I946V|UNC13A_ENST00000519716.2_Missense_Mutation_p.I946V|UNC13A_ENST00000252773.7_Missense_Mutation_p.I946V			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	946					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GAGAGGTCAATCCGCAGGGAG	0.577000													12	49					0	0	0.000308642	0	0
PIGG	54872	broad.mit.edu	37	4	502694	502694	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr4:502694C>T	ENST00000453061.2	+	5	942	c.836C>T	c.(835-837)gCc>gTc	p.A279V	PIGG_ENST00000503111.1_Missense_Mutation_p.A190V|PIGG_ENST00000383028.4_Missense_Mutation_p.A146V|PIGG_ENST00000504346.1_Missense_Mutation_p.A190V|PIGG_ENST00000536264.1_Missense_Mutation_p.A157V|PIGG_ENST00000310340.5_Missense_Mutation_p.A279V|PIGG_ENST00000296306.7_Missense_Mutation_p.A190V|PIGG_ENST00000509768.1_Missense_Mutation_p.A190V	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	279					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						AGTCACGGGGCCTCCTCCACC	0.443000													12	73					0	0	0.00136819	0	0
FAT2	2196	broad.mit.edu	37	5	150947463	150947463	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr5:150947463delA	ENST00000261800.5	-	1	1042	c.1030delT	c.(1030-1032)atfs	p.Y344fs		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	344					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCTGGGAATAAAAATAAGGG	0.498													19	189	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100369720	100369721	+	RNA	INS	-	-	T			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr7:100369720_100369721insT	ENST00000542585.1	+	0	5573				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			cctctaaattcttttttttttt	0.535													4	2	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28209226	28209228	+	In_Frame_Del	DEL	GCA	GCA	-	rs142343457	byFrequency	TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr8:28209226_28209228delGCA	ENST00000344423.5	-	7	1148_1150	c.1017_1019delTGC	c.(1015-1020)gcc>gc	p.AA339del	ZNF395_ENST00000523095.1_In_Frame_Del_p.AA339del|ZNF395_ENST00000523202.1_In_Frame_Del_p.AA339del	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	339					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGTGCCTgcggcagcagcagcag	0.606													7	167	---	---	---	---					
A1CF	29974	broad.mit.edu	37	10	52573648	52573648	+	Frame_Shift_Del	DEL	A	A	-	rs140399088		TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr10:52573648delA	ENST00000395489.2	-	12	1691	c.1295delT	c.(1294-1296)tafs	p.L432fs	A1CF_ENST00000373993.1_Frame_Shift_Del_p.L439fs|A1CF_ENST00000395495.1_Frame_Shift_Del_p.L384fs|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000282641.2_Frame_Shift_Del_p.L439fs|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000373997.3_Frame_Shift_Del_p.L431fs|A1CF_ENST00000374001.1_Frame_Shift_Del_p.L431fs|A1CF_ENST00000373995.3_Frame_Shift_Del_p.L439fs	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	439					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TTGGGGTTTTAATGTGACAGG	0.418													19	106	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	RNA	DEL	GT	GT	-			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr11:14276276_14276277delGT	ENST00000310358.7	+	0	1627							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													7	64	---	---	---	---					
FITM1	161247	broad.mit.edu	37	14	24600735	24600735	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr14:24600735delC	ENST00000558325.1	+	3	525	c.525delC	c.(523-525)tgfs	p.175fs	FITM1_ENST00000267426.5_5'UTR																							TCCTCAGCTGCCCAGCAAAGC	0.682													2	4	---	---	---	---					
LOC101927755	101927755	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													3	4	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-6978-01A-11D-1945-08	TCGA-55-6978-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d44bbc31-efda-4b1d-804f-9dc9ba1684ee	bef20a84-615a-481d-a608-fe9071ab24e7	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													9	505	---	---	---	---					
