Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HAS2	3037	broad.mit.edu	37	8	122626563	122626563	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:122626563G>A	ENST00000303924.4	-	4	1982	c.1445C>T	c.(1444-1446)tCa>tTa	p.S482L		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	482						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AAACCAAACTGATACTGGAAT	0.403000													11	98					0	0	0.001368	0	0
COL14A1	7373	broad.mit.edu	37	8	121267561	121267561	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:121267561C>A	ENST00000297848.3	+	23	3105	c.2835C>A	c.(2833-2835)gcC>gcA	p.A945A	COL14A1_ENST00000247781.3_Silent_p.A850A|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Silent_p.A945A	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	945	Fibronectin type-III 8.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ATCGCCATGCCACAGCCTATA	0.443000													5	95					0.000602214	0.00103512	0.000602	1	0
SLC35B4	84912	broad.mit.edu	37	7	133984945	133984945	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:133984945T>A	ENST00000378509.4	-	7	855	c.556A>T	c.(556-558)Aaa>Taa	p.K186*		NM_032826.4	NP_116215.1	Q969S0	S35B4_HUMAN	solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4	186						Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			large_intestine(1)|lung(2)|skin(1)|stomach(1)	5						CCAAATCGTTTGTAGAGAGTC	0.393000													15	70					0	0	0.000743	0	0
GBP2	2634	broad.mit.edu	37	1	89587488	89587488	+	Silent	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:89587488C>G	ENST00000370466.3	-	2	430	c.162G>C	c.(160-162)ctG>ctC	p.L54L		NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	54					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		GCTTGTTCATCAGGTAGGATT	0.527000													4	96					0	0	0.000248	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949102	59949102	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:59949102C>A	ENST00000528851.1	-	2	239	c.99G>T	c.(97-99)ggG>ggT	p.G33G	MS4A6A_ENST00000420732.2_Silent_p.G33G|MS4A6A_ENST00000529054.1_Silent_p.G61G|MS4A6A_ENST00000530839.1_Silent_p.G33G|MS4A6A_ENST00000532169.1_Silent_p.G33G|MS4A6A_ENST00000426738.2_Silent_p.G33G|MS4A6A_ENST00000412309.2_Silent_p.G61G|MS4A6A_ENST00000323961.3_Silent_p.G33G|MS4A6A_ENST00000533023.1_Silent_p.G33G			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	33						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGCTATCCTGCCCCTGGTTGG	0.473000													9	110					2.52707e-12	5.59896e-12	0.000443	1	0
ST7L	54879	broad.mit.edu	37	1	113098567	113098567	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:113098567G>C	ENST00000358039.4	-	12	1623	c.1319C>G	c.(1318-1320)gCc>gGc	p.A440G	ST7L_ENST00000343210.7_Missense_Mutation_p.A440G|ST7L_ENST00000369669.1_Missense_Mutation_p.A257G|ST7L_ENST00000544629.1_Missense_Mutation_p.A375G|ST7L_ENST00000543570.1_Intron|ST7L_ENST00000538187.1_Missense_Mutation_p.A384G|ST7L_ENST00000490067.1_Missense_Mutation_p.A423G|ST7L_ENST00000463235.1_5'UTR|ST7L_ENST00000369666.1_Missense_Mutation_p.A423G|ST7L_ENST00000369668.2_Missense_Mutation_p.A440G|ST7L_ENST00000360743.4_Missense_Mutation_p.A440G	NM_017744.4|NM_138727.3	NP_060214.2|NP_620055.1	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7 like	440					negative regulation of cell growth	integral to membrane	binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(1)|prostate(2)|stomach(1)|urinary_tract(3)	15	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAAGCATAGGCAATTGCTTC	0.363000													6	47					0	0	0.001984	0	0
LEPR	3953	broad.mit.edu	37	1	66067104	66067104	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:66067104A>G	ENST00000349533.6	+	9	1209	c.1024A>G	c.(1024-1026)Aca>Gca	p.T342A	LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371058.1_Missense_Mutation_p.T342A|LEPR_ENST00000344610.8_Missense_Mutation_p.T342A|LEPR_ENST00000371059.3_Missense_Mutation_p.T342A|LEPR_ENST00000371060.3_Missense_Mutation_p.T342A	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	342	Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TAAAATTCTGACAAGTGTTGG	0.343000													5	47					0	0	0.001168	0	0
ISM2	145501	broad.mit.edu	37	14	77942010	77942010	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:77942010G>A	ENST00000393684.3	-	8	1771	c.1380C>T	c.(1378-1380)aaC>aaT	p.N460N	ISM2_ENST00000493585.1_3'UTR|ISM2_ENST00000429906.1_Silent_p.N467N|ISM2_ENST00000412904.1_Silent_p.N467N|ISM2_ENST00000342219.4_Silent_p.N548N			Q6H9L7	ISM2_HUMAN	isthmin 2	548	AMOP.					extracellular region		p.N548N(1)		endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						AGGCTCGGCCGTTGTTGGGAG	0.612000													5	63					0	0	0.001168	0	0
DISP1	84976	broad.mit.edu	37	1	223178684	223178684	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:223178684G>A	ENST00000284476.6	+	8	4109	c.3945G>A	c.(3943-3945)ctG>ctA	p.L1315L		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1315					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		TGGCACCTCTGAAGGCCACAC	0.592000													20	80					0	0	0.001216	0	0
OR56A1	120796	broad.mit.edu	37	11	6048350	6048350	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:6048350G>A	ENST00000316650.5	-	1	621	c.585C>T	c.(583-585)tcC>tcT	p.S195S		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATTATCACAGGAGAGCCTGG	0.458000													6	58					0	0	0.001984	0	0
CLK2	1196	broad.mit.edu	37	1	155238556	155238556	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:155238556C>G	ENST00000368361.4	-	4	745	c.430G>C	c.(430-432)Gag>Cag	p.E144Q	CLK2_ENST00000355560.4_Missense_Mutation_p.E142Q|CLK2_ENST00000536801.1_Missense_Mutation_p.E144Q|CLK2_ENST00000361168.5_Missense_Mutation_p.E143Q|CLK2_ENST00000497188.1_5'UTR			P49760	CLK2_HUMAN	CDC-like kinase 2	144						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCGTCGTCCTCTACACTCTTG	0.637000								Other conserved DNA damage response genes					12	92					0	0	0.001855	0	0
FAM63A	55793	broad.mit.edu	37	1	150974245	150974245	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:150974245G>A	ENST00000361936.5	-	4	1421	c.467C>T	c.(466-468)cCg>cTg	p.P156L	FAM63A_ENST00000361738.6_Missense_Mutation_p.P204L|FAM63A_ENST00000312210.5_Missense_Mutation_p.P14L|FAM63A_ENST00000470877.1_5'UTR|FAM63A_ENST00000493834.2_Missense_Mutation_p.P61L	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	156							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTCCTTCTGCGGGGGGAGCTT	0.562000													14	45					0	0	0.002450	0	0
URGCP	55665	broad.mit.edu	37	7	43917438	43917438	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:43917438G>A	ENST00000336086.6	-	4	3731	c.1495C>T	c.(1495-1497)Cat>Tat	p.H499Y	RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000223341.7_Missense_Mutation_p.H499Y|URGCP_ENST00000443736.1_Missense_Mutation_p.H499Y|URGCP_ENST00000453200.1_Missense_Mutation_p.H542Y|URGCP_ENST00000402306.3_Missense_Mutation_p.H533Y|URGCP_ENST00000447717.3_Missense_Mutation_p.H499Y|URGCP_ENST00000497914.1_5'UTR			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	542					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAGGGATCATGGCCGTTCTGC	0.627000													4	45					0	0	0.000248	0	0
CNOT1	23019	broad.mit.edu	37	16	58620566	58620566	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:58620566G>C	ENST00000317147.5	-	7	852	c.520C>G	c.(520-522)Caa>Gaa	p.Q174E	CNOT1_ENST00000441024.2_Missense_Mutation_p.Q174E|CNOT1_ENST00000569240.1_Missense_Mutation_p.Q174E	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	174					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCTATATCTTGGAAGCCACCT	0.473000													4	297					0	0	0.000602	0	0
ZNF710	374655	broad.mit.edu	37	15	90611352	90611352	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:90611352G>T	ENST00000268154.4	+	2	1234	c.983G>T	c.(982-984)tGc>tTc	p.C328F		NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGCCCACACTGCAGCAAGCTC	0.622000													6	50					3.59834e-05	6.58332e-05	0.001168	1	0
GRM7	2917	broad.mit.edu	37	3	7620456	7620456	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:7620456C>T	ENST00000486284.1	+	8	2137	c.1863C>T	c.(1861-1863)gtC>gtT	p.V621V	GRM7_ENST00000389336.4_Silent_p.V621V|GRM7_ENST00000403881.1_Silent_p.V621V|GRM7_ENST00000357716.4_Silent_p.V621V|GRM7_ENST00000402647.2_Silent_p.V621V|GRM7_ENST00000458641.2_3'UTR	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	621					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CGCCCATTGTCCGGGCATCTG	0.512000													22	96					0	0	0.001882	0	0
EIF3A	8661	broad.mit.edu	37	10	120797844	120797844	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:120797844C>A	ENST00000369144.3	-	20	3761	c.3634G>T	c.(3634-3636)Gat>Tat	p.D1212Y	EIF3A_ENST00000478852.1_Intron|EIF3A_ENST00000541549.1_Missense_Mutation_p.D1178Y	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1212	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		tcttgattatctctgtccctt	0.493000													23	109					3.8784e-16	8.63258e-16	0.001882	1	0
OR2L13	284521	broad.mit.edu	37	1	248263597	248263597	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:248263597T>C	ENST00000366478.2	+	3	1257	c.920T>C	c.(919-921)tTc>tCc	p.F307S	OR2L13_ENST00000358120.2_Missense_Mutation_p.F307S	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TTTGGGATATTCTCTTTCCTG	0.458000													3	40					0	0	0.000248	0	0
SLA	6503	broad.mit.edu	37	8	134050875	134050875	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:134050875T>A	ENST00000338087.5	-	9	1544	c.725A>T	c.(724-726)gAg>gTg	p.E242V	SLA_ENST00000395352.3_Missense_Mutation_p.E259V|SLA_ENST00000427060.2_Missense_Mutation_p.E282V|TG_ENST00000519543.1_Intron|TG_ENST00000220616.4_Intron|TG_ENST00000542445.1_Intron|SLA_ENST00000524345.1_Missense_Mutation_p.E134V|TG_ENST00000377869.1_Intron|SLA_ENST00000517648.1_Missense_Mutation_p.E215V	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	242	SLA C-terminal.					endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			GGTGTTGTCCTCACTGGTCAG	0.512000													16	69					0	0	0.003163	0	0
GPATCH1	55094	broad.mit.edu	37	19	33588673	33588673	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:33588673G>C	ENST00000170564.2	+	8	1179	c.865G>C	c.(865-867)Ggt>Cgt	p.G289R		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	289						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TTTTGGTGTAGGTGCCCTGGA	0.443000													19	107					0	0	0.000958	0	0
NBPF1	55672	broad.mit.edu	37	1	16918399	16918399	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:16918399C>G	ENST00000430580.2	-	7	1005	c.118G>C	c.(118-120)Gag>Cag	p.E40Q		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	40						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AAACATTTCTCTTTGAGGTTT	0.458000													18	1121					0	0	0.002450	0	0
NDST3	9348	broad.mit.edu	37	4	119064762	119064762	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:119064762G>C	ENST00000296499.5	+	6	1865	c.1462G>C	c.(1462-1464)Gaa>Caa	p.E488Q	NDST3_ENST00000433996.2_Missense_Mutation_p.E407Q	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	488	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						TTTCTACAAAGAATATCCAGG	0.388000													3	44					0	0	0.000248	0	0
PCDHA5	56143	broad.mit.edu	37	5	140201934	140201934	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:140201934G>T	ENST00000529859.1	+	1	574	c.574G>T	c.(574-576)Gag>Tag	p.E192*	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Nonsense_Mutation_p.E192*|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000378126.3_Nonsense_Mutation_p.E192*|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACTTTTTAGAGCTGGTTTT	0.348000													8	49					0.000274275	0.000481727	0.004482	1	0
JMY	133746	broad.mit.edu	37	5	78573820	78573820	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:78573820G>A	ENST00000396137.4	+	2	1582	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K		NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	374					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		CAGCCTTGCAGAAGCTACAAC	0.438000													12	69					0	0	0.001855	0	0
KCNG3	170850	broad.mit.edu	37	2	42671645	42671645	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:42671645C>G	ENST00000306078.1	-	2	1335	c.740G>C	c.(739-741)tGt>tCt	p.C247S	KCNG3_ENST00000394973.4_Missense_Mutation_p.C236S	NM_133329.5|NM_172344.2	NP_579875.1|NP_758847.1	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G, member 3	247						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	6						GACAAACTCACACTTGTTTTT	0.423000													4	68					0	0	0.000248	0	0
OR5L1	219437	broad.mit.edu	37	11	55578976	55578976	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:55578976T>G	ENST00000333973.2	+	1	123	c.34T>G	c.(34-36)Ttc>Gtc	p.F12V		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGTGGCTGAGTTCATTCTCCT	0.418000													10	185					0	0	0.001368	0	0
OR52R1	119695	broad.mit.edu	37	11	4824894	4824894	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:4824894T>G	ENST00000380382.1	-	1	953	c.954A>C	c.(952-954)aaA>aaC	p.K318N	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.K239N|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTAAAAGCTTTGAGGCGGG	0.483000													3	45					0	0	0.004672	0	0
RASA4B	100271927	broad.mit.edu	37	7	102136619	102136619	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:102136619G>A	ENST00000481893.1	-	16	1947	c.823C>T	c.(823-825)Ctg>Ttg	p.L275L	RASA4B_ENST00000541662.1_Silent_p.L347L|RASA4B_ENST00000306682.6_Silent_p.L275L|RASA4B_ENST00000465829.1_Silent_p.L347L					RAS p21 protein activator 4B											skin(1)	1						TTTGAGGCCAGAGAGTTGCTC	0.537000													10	220					0	0	0.001368	0	0
LY9	4063	broad.mit.edu	37	1	160771687	160771687	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:160771687G>A	ENST00000368039.2	+	3	563	c.562G>A	c.(562-564)Gtg>Atg	p.V188M	LY9_ENST00000368041.2_Intron|LY9_ENST00000368040.1_Intron|LY9_ENST00000341032.4_Intron|LY9_ENST00000263285.5_Intron|LY9_ENST00000471816.1_Intron	NM_001033667.2	NP_001028839.1	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	0	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TGAGCCACGTGTGAGCGTGCG	0.667000													7	101					0	0	0.001984	0	0
SLC39A1	27173	broad.mit.edu	37	1	153932779	153932779	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:153932779C>T	ENST00000368623.3	-	3	1529	c.770G>A	c.(769-771)gGt>gAt	p.G257D	SLC39A1_ENST00000310483.6_Missense_Mutation_p.G257D|SLC39A1_ENST00000368621.1_Missense_Mutation_p.G257D|SLC39A1_ENST00000537590.1_Missense_Mutation_p.G155D|SLC39A1_ENST00000356205.4_Missense_Mutation_p.G257D			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	257						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		CAGAGCTGCACCCAGCCCGAT	0.602000													15	42					0	0	0.002450	0	0
DACH2	117154	broad.mit.edu	37	X	85769388	85769388	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:85769388C>A	ENST00000373131.1	+	2	758	c.595C>A	c.(595-597)Ccg>Acg	p.P199T	DACH2_ENST00000510272.1_5'UTR|DACH2_ENST00000373125.4_Missense_Mutation_p.P212T|DACH2_ENST00000508860.1_Missense_Mutation_p.P45T	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						ACTTATCACTCCGACAGGTAA	0.498000													4	11					1.23904e-05	2.3196e-05	0.000602	1	0
ZNF157	7712	broad.mit.edu	37	X	47269685	47269685	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:47269685C>T	ENST00000377073.3	+	2	169	c.83C>T	c.(82-84)tCa>tTa	p.S28L		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	28	KRAB.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GGGTCCGTGTCATTCGAGGAT	0.493000													15	60					0	0	0.003163	0	0
DNAH9	1770	broad.mit.edu	37	17	11592889	11592889	+	Silent	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:11592889T>C	ENST00000262442.3	+	20	3818	c.3750T>C	c.(3748-3750)gaT>gaC	p.D1250D	DNAH9_ENST00000454412.2_Silent_p.D1250D	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1250	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTAGGTTTGATAGCATCCACC	0.468000													14	64					0	0	0.003163	0	0
ADCY5	111	broad.mit.edu	37	3	123010084	123010084	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:123010084T>C	ENST00000462833.1	-	18	4415	c.3203A>G	c.(3202-3204)gAg>gGg	p.E1068G	ADCY5_ENST00000491190.1_Missense_Mutation_p.E726G|ADCY5_ENST00000309879.5_Missense_Mutation_p.E718G	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1068					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CGCCACACACTCACAGGACTG	0.597000													4	59					0	0	0.000248	0	0
PNISR	25957	broad.mit.edu	37	6	99854026	99854026	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:99854026C>T	ENST00000369239.5	-	8	1087	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	PNISR_ENST00000438806.1_Missense_Mutation_p.E295K	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	295						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TCAGTGTCTTCTTCTTCCTCA	0.388000													3	33					0	0	0.000248	0	0
PARP10	84875	broad.mit.edu	37	8	145057150	145057150	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:145057150C>A	ENST00000313028.7	-	9	2600	c.2506G>T	c.(2506-2508)Gcc>Tcc	p.A836S	PARP10_ENST00000524918.1_Missense_Mutation_p.A827S|PARP10_ENST00000525773.1_Missense_Mutation_p.A848S	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	836	Myc binding.|PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGTAGAAGGCCCGCACCACC	0.642000													4	61					2.56e-06	5.02634e-06	0.000248	1	0
EYS	346007	broad.mit.edu	37	6	66054009	66054009	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:66054009G>T	ENST00000503581.1	-	10	2058	c.1521C>A	c.(1519-1521)tgC>tgA	p.C507*	EYS_ENST00000393380.2_Nonsense_Mutation_p.C507*|EYS_ENST00000370618.3_Nonsense_Mutation_p.C507*|EYS_ENST00000370621.3_Nonsense_Mutation_p.C507*|EYS_ENST00000370616.2_Nonsense_Mutation_p.C507*|EYS_ENST00000342421.5_Nonsense_Mutation_p.C507*	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	507					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CATCTTCAGTGCAGTTTGCAG	0.353000													12	41					3.07112e-06	5.98125e-06	0.000978	1	0
FUT10	84750	broad.mit.edu	37	8	33247083	33247083	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:33247083T>A	ENST00000327671.5	-	4	1241	c.610A>T	c.(610-612)Aaa>Taa	p.K204*	FUT10_ENST00000518076.1_5'UTR|FUT10_ENST00000524021.1_Nonsense_Mutation_p.K176*|FUT10_ENST00000518672.1_Nonsense_Mutation_p.K176*|FUT10_ENST00000335589.3_Nonsense_Mutation_p.K142*	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	204					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		AGCTTGTTTTTGGACTGCAAA	0.483000													10	120					0	0	0.000443	0	0
FBN2	2201	broad.mit.edu	37	5	127673703	127673703	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:127673703C>A	ENST00000508053.1	-	33	4558	c.3584G>T	c.(3583-3585)cGt>cTt	p.R1195L	FBN2_ENST00000507835.1_Missense_Mutation_p.R45L|FBN2_ENST00000262464.4_Missense_Mutation_p.R1195L|FBN2_ENST00000508989.1_Missense_Mutation_p.R1162L			P35556	FBN2_HUMAN	fibrillin 2	1195	EGF-like 17; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.R1195L(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACAGTCCTCACGGGATGGTGA	0.527000													4	28					0.00024832	0.000440951	0.000248	1	0
NCF4	4689	broad.mit.edu	37	22	37268425	37268425	+	Silent	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:37268425T>C	ENST00000397147.4	+	7	769	c.585T>C	c.(583-585)gaT>gaC	p.D195D	NCF4_ENST00000248899.6_Silent_p.D195D	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	195	SH3.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AAGCTGGAGATGTGATCTTCC	0.478000													14	74					0	0	0.004990	0	0
NNT	23530	broad.mit.edu	37	5	43609421	43609421	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:43609421C>T	ENST00000264663.5	+	2	345	c.124C>T	c.(124-126)Ctg>Ttg	p.L42L	NNT_ENST00000512996.2_Intron|NNT_ENST00000344920.4_Silent_p.L42L	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	42					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	TCACCAAGAACTGTGGTGTAA	0.403000													3	47					0	0	0.004672	0	0
PDZD2	23037	broad.mit.edu	37	5	32089285	32089285	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:32089285A>G	ENST00000438447.1	+	20	6119	c.5731A>G	c.(5731-5733)Acg>Gcg	p.T1911A	PDZD2_ENST00000282493.3_Missense_Mutation_p.T1911A			O15018	PDZD2_HUMAN	PDZ domain containing 2	1911					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GGCTGGGGGGACGGACCACAG	0.582000													3	73					0	0	0.004672	0	0
VOPP1	81552	broad.mit.edu	37	7	55565370	55565370	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:55565370C>T	ENST00000285279.5	-	3	327	c.127G>A	c.(127-129)Gag>Aag	p.E43K	VOPP1_ENST00000454227.1_Intron|VOPP1_ENST00000433959.1_Missense_Mutation_p.E34K|VOPP1_ENST00000545390.1_Missense_Mutation_p.E40K|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000471168.1_5'UTR|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000418904.1_Missense_Mutation_p.E26K|VOPP1_ENST00000427700.1_Missense_Mutation_p.E41K|VOPP1_ENST00000453256.1_5'UTR	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						CAGCAGTCCTCGTAGGAGCGG	0.597000													5	54					0	0	0.000602	0	0
C16orf45	89927	broad.mit.edu	37	16	15675108	15675108	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:15675108G>A	ENST00000300006.4	+	4	698	c.339G>A	c.(337-339)gaG>gaA	p.E113E	C16orf45_ENST00000566490.1_Silent_p.E113E|C16orf45_ENST00000565913.1_3'UTR|C16orf45_ENST00000561692.1_Silent_p.E65E|C16orf45_ENST00000452191.2_Silent_p.E96E	NM_033201.2	NP_149978.1	Q96MC5	CP045_HUMAN	chromosome 16 open reading frame 45	113										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)	11						AGCAGAGAGAGGATGAGCTAA	0.502000													11	15					0	0	0.001855	0	0
CPA2	1358	broad.mit.edu	37	7	129919434	129919434	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:129919434A>T	ENST00000222481.4	+	9	974	c.919A>T	c.(919-921)Agc>Tgc	p.S307C		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	307	Substrate binding (By similarity).				proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					TACCCTCCACAGCTATTCCCA	0.443000													11	54					0	0	0.000978	0	0
KIF12	113220	broad.mit.edu	37	9	116854684	116854684	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:116854684G>A	ENST00000374118.3	-	15	1568	c.1331C>T	c.(1330-1332)aCg>aTg	p.T444M		NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	577					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CTCCTCCTCCGTCAACATCTC	0.622000													5	93					0	0	0.003080	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25268403	25268403	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:25268403C>G	ENST00000328086.7	-	1	849	c.46G>C	c.(46-48)Gag>Cag	p.E16Q		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	16					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		AGGCATCCCTCAACCTCCAGG	0.562000											OREG0023690	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	98					0	0	0.003080	0	0
TRRAP	8295	broad.mit.edu	37	7	98609091	98609091	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:98609091G>T	ENST00000359863.4	+	71	11437	c.11228G>T	c.(11227-11229)gGg>gTg	p.G3743V	TRRAP_ENST00000446306.3_Missense_Mutation_p.G3732V|TRRAP_ENST00000355540.3_Missense_Mutation_p.G3714V	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3743	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.G3714E(2)|p.G3743E(2)		NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACCACCATCGGGGTCTCCGGC	0.572000													10	79					0.000673444	0.00115345	0.000673	1	0
ZHX3	23051	broad.mit.edu	37	20	39832030	39832030	+	Silent	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:39832030C>G	ENST00000309060.3	-	4	1942	c.1527G>C	c.(1525-1527)ctG>ctC	p.L509L	ZHX3_ENST00000540170.1_Silent_p.L509L|ZHX3_ENST00000560361.1_Silent_p.L509L|ZHX3_ENST00000432768.2_Silent_p.L509L|ZHX3_ENST00000559234.1_Silent_p.L509L|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000544979.2_Silent_p.L509L			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	509	Required for nuclear localization.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				AGCTCCCTTTCAGAGCTGACA	0.522000													8	41					0	0	0.003080	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168424	25168424	+	RNA	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr13:25168424G>A	ENST00000453498.1	+	0	1096																											GCATGACATTGAAACAGCTGG	0.363000													5	17					0	0	0.000602	0	0
SMTN	6525	broad.mit.edu	37	22	31484501	31484501	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:31484501C>G	ENST00000333137.7	+	4	421	c.203C>G	c.(202-204)tCt>tGt	p.S68C	SMTN_ENST00000358743.1_Missense_Mutation_p.S68C|SMTN_ENST00000347557.2_Missense_Mutation_p.S68C|SMTN_ENST00000475548.1_3'UTR	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	68					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						CTCTGCAGCTCTCAGCAGCGG	0.607000													15	82					0	0	0.000743	0	0
TCF25	22980	broad.mit.edu	37	16	89967051	89967051	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:89967051G>C	ENST00000263346.8	+	12	1286	c.1230G>C	c.(1228-1230)cgG>cgC	p.R410R	TCF25_ENST00000263347.7_Silent_p.R175R	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	410					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		AGGCTCATCGGAACCTGTCCC	0.522000													6	55					0	0	0.001984	0	0
EPHA7	2045	broad.mit.edu	37	6	93982064	93982064	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:93982064C>A	ENST00000369303.4	-	6	1585	c.1401G>T	c.(1399-1401)gaG>gaT	p.E467D		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	467	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CATTGGGATGCTCTGGTTCCT	0.448000													17	107					1.99824e-07	4.10701e-07	0.004990	1	0
OR1L1	26737	broad.mit.edu	37	9	125424358	125424358	+	Missense_Mutation	SNP	C	C	T	rs146376238		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:125424358C>T	ENST00000373686.1	+	1	514	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						GGCCATTGACCGCTATGTGGC	0.458000													32	198					0	0	0.001786	0	0
OR6K3	391114	broad.mit.edu	37	1	158687325	158687325	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:158687325A>T	ENST00000368146.1	-	1	628	c.629T>A	c.(628-630)aTg>aAg	p.M210K	OR6K3_ENST00000368145.1_Missense_Mutation_p.M194K			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					AATCAGAATCATGGACGTGTC	0.453000													15	142					0	0	0.004007	0	0
CDH26	60437	broad.mit.edu	37	20	58569350	58569350	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:58569350C>T	ENST00000348616.4	+	11	1772	c.1472C>T	c.(1471-1473)tCt>tTt	p.S491F	CDH26_ENST00000244047.5_Missense_Mutation_p.S491F|CDH26_ENST00000497614.1_3'UTR	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	491	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CTCTTCCTGTCTGACATCAAT	0.557000													6	37					0	0	0.001984	0	0
HSPB8	26353	broad.mit.edu	37	12	119617367	119617367	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:119617367G>A	ENST00000281938.2	+	1	921	c.250G>A	c.(250-252)Gag>Aag	p.E84K		NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	84					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity	p.E84K(2)|p.E84*(2)|p.E84Q(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGCCTGCCGAGGGCAGGAC	0.657000													6	37					0	0	0.001168	0	0
OR5J2	282775	broad.mit.edu	37	11	55944365	55944365	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:55944365C>G	ENST00000312298.1	+	1	272	c.272C>G	c.(271-273)aCa>aGa	p.T91R		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GTGAAGGCAACAATTTCTTTC	0.453000													7	98					0	0	0.001984	0	0
TLK1	9874	broad.mit.edu	37	2	171863128	171863128	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:171863128C>G	ENST00000442919.2	-	17	2095	c.1480G>C	c.(1480-1482)Gaa>Caa	p.E494Q	TLK1_ENST00000360843.3_Missense_Mutation_p.E563Q|TLK1_ENST00000431350.2_Missense_Mutation_p.E542Q|TLK1_ENST00000434911.2_Missense_Mutation_p.E446Q|TLK1_ENST00000521943.1_Missense_Mutation_p.E494Q	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	542	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TCATTGCCTTCACAGTATTCT	0.348000													7	75					0	0	0.004482	0	0
NRDE2	55051	broad.mit.edu	37	14	90770522	90770522	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:90770522T>C	ENST00000354366.3	-	5	994	c.762A>G	c.(760-762)atA>atG	p.I254M	NRDE2_ENST00000357904.3_Missense_Mutation_p.I23M	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CCTTCACTGGTATAAAGGAGA	0.453000													6	83					0	0	0.001984	0	0
NUFIP2	57532	broad.mit.edu	37	17	27613571	27613571	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:27613571T>C	ENST00000225388.4	-	2	1499	c.1441A>G	c.(1441-1443)Atg>Gtg	p.M481V	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	481						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			CTCAACAGCATAGTTTGCATA	0.413000													4	56					0	0	0.000248	0	0
DSP	1832	broad.mit.edu	37	6	7572109	7572109	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:7572109C>A	ENST00000379802.3	+	15	2279	c.1938C>A	c.(1936-1938)tgC>tgA	p.C646*	DSP_ENST00000418664.2_Nonsense_Mutation_p.C646*	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	646	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATGGAACCTGCCAAGATGTCA	0.413000													14	87					1.3612e-06	2.7056e-06	0.003163	1	0
RTN4RL2	349667	broad.mit.edu	37	11	57235087	57235087	+	Missense_Mutation	SNP	G	G	A	rs140089941		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:57235087G>A	ENST00000335099.3	+	2	354	c.37G>A	c.(37-39)Gcc>Acc	p.A13T	RTN4RL2_ENST00000395120.2_Missense_Mutation_p.A13T|RTN4RL2_ENST00000533205.1_Missense_Mutation_p.A13T	NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	13					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CACAGCTCCCGCCTCGGCCTG	0.682000													6	62					0	0	0.001168	0	0
CTNND2	1501	broad.mit.edu	37	5	11111044	11111044	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:11111044C>T	ENST00000304623.8	-	14	2578	c.2389G>A	c.(2389-2391)Gag>Aag	p.E797K	CTNND2_ENST00000359640.2_Missense_Mutation_p.E797K|CTNND2_ENST00000503622.1_Missense_Mutation_p.E460K|CTNND2_ENST00000458100.2_Missense_Mutation_p.E364K|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.E706K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	797					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CCATTGGCCTCGCCACAGAGT	0.562000													16	246					0	0	0.004990	0	0
FAF2	23197	broad.mit.edu	37	5	175913446	175913446	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:175913446G>C	ENST00000261942.6	+	3	276	c.223G>C	c.(223-225)Gac>Cac	p.D75H	FAF2_ENST00000510446.1_3'UTR	NM_014613.2	NP_055428.1	Q96CS3	FAF2_HUMAN	Fas associated factor family member 2	75					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			breast(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TAATACAGCTGACCACAGGAT	0.453000													8	56					0	0	0.004482	0	0
RYR3	6263	broad.mit.edu	37	15	33905510	33905510	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:33905510G>C	ENST00000389232.4	+	19	2361	c.2291G>C	c.(2290-2292)gGg>gCg	p.G764A	RYR3_ENST00000415757.3_Missense_Mutation_p.G764A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	764	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCCGTGCAGGGGATGTTTGAG	0.532000													3	31					0	0	0.004672	0	0
RRAGB	10325	broad.mit.edu	37	X	55755773	55755773	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:55755773G>C	ENST00000374941.4	+	4	862	c.273G>C	c.(271-273)ttG>ttC	p.L91F	RRAGB_ENST00000262850.7_Missense_Mutation_p.L119F	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	119					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						ACCTGGTATTGAACCTGTGGG	0.398000													6	34					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179455242	179455242	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:179455242G>A	ENST00000589042.1	-	304	61434	c.61210C>T	c.(61210-61212)Cta>Tta	p.L20404L	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000591111.1_Silent_p.L18763L|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Silent_p.L11464L|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Silent_p.L17836L|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Silent_p.L11339L|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.L11531L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18763	Fibronectin type-III 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATATCCTAGAATGGGGCTA	0.448000													8	119					0	0	0.004482	0	0
OTOF	9381	broad.mit.edu	37	2	26684613	26684613	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:26684613G>C	ENST00000272371.2	-	43	5610	c.5484C>G	c.(5482-5484)ctC>ctG	p.L1828L	OTOF_ENST00000403946.3_Silent_p.L1828L|OTOF_ENST00000402415.3_Silent_p.L1138L|OTOF_ENST00000339598.3_Silent_p.L1061L|OTOF_ENST00000338581.6_Silent_p.L1061L	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1828					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGCAGGGTGAGCCGCGCGG	0.607000													8	94					0	0	0.003080	0	0
RBM41	55285	broad.mit.edu	37	X	106310824	106310824	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:106310824G>C	ENST00000372487.1	-	7	1201	c.1175C>G	c.(1174-1176)tCa>tGa	p.S392*	RBM41_ENST00000372479.3_Nonsense_Mutation_p.S392*	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	392							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						TTGGAGATTTGACCGTTGCTT	0.383000													19	109					0	0	0.000743	0	0
PRG4	10216	broad.mit.edu	37	1	186276052	186276052	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:186276052A>C	ENST00000445192.2	+	7	1246	c.1201A>C	c.(1201-1203)Acc>Ccc	p.T401P	PRG4_ENST00000367485.4_Missense_Mutation_p.T308P|PRG4_ENST00000367483.4_Missense_Mutation_p.T360P|PRG4_ENST00000367486.3_Missense_Mutation_p.T358P|PRG4_ENST00000367484.3_Missense_Mutation_p.T360P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	401	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T401P(4)|p.T400>?(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCACCAAGGAGCC	0.642000													6	69					0	0	0.003080	0	0
FARSA	2193	broad.mit.edu	37	19	13035517	13035517	+	Silent	SNP	C	C	T	rs113870503	byFrequency	TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:13035517C>T	ENST00000588025.1	-	11	1391	c.1251G>A	c.(1249-1251)gtG>gtA	p.V417V	FARSA_ENST00000423140.2_Silent_p.V346V|FARSA_ENST00000314606.4_Silent_p.V377V			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	377					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	CATGATCCGCCACCACGCCCT	0.627000													12	37					0	0	0.000978	0	0
TRPM1	4308	broad.mit.edu	37	15	31341653	31341653	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:31341653C>T	ENST00000542188.1	-	12	1861	c.1548G>A	c.(1546-1548)gtG>gtA	p.V516V	TRPM1_ENST00000397795.2_Silent_p.V477V|TRPM1_ENST00000256552.6_Silent_p.V499V	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	477					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCAGGAGCTTCACAAAGTCGA	0.502000													16	85					0	0	0.004007	0	0
OR5T1	390155	broad.mit.edu	37	11	56044014	56044014	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:56044014C>T	ENST00000313033.2	+	1	986	c.900C>T	c.(898-900)atC>atT	p.I300I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TGAATCCCATCATCTACAGTT	0.353000													9	79					0	0	0.004482	0	0
NSMCE2	286053	broad.mit.edu	37	8	126194398	126194398	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:126194398G>A	ENST00000287437.3	+	5	534	c.318G>A	c.(316-318)aaG>aaA	p.K106K	NSMCE2_ENST00000522563.1_Silent_p.K106K|NSMCE2_ENST00000517315.1_Silent_p.K46K	NM_173685.2	NP_775956.1	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog (S. cerevisiae)	106					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			TGGTAGAGAAGAAATTTTTGG	0.294000													4	94					0	0	0.000248	0	0
TRAV9-1	28678	broad.mit.edu	37	14	22280084	22280084	+	RNA	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:22280084T>C	ENST00000390431.3	+	0	273																											AAACCACTTCTTTCCACTTGG	0.498000													6	34					0	0	0.001168	0	0
COL11A1	1301	broad.mit.edu	37	1	103352393	103352393	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:103352393G>T	ENST00000358392.2	-	63	5181	c.4864C>A	c.(4864-4866)Ctg>Atg	p.L1622M	COL11A1_ENST00000353414.4_Missense_Mutation_p.L1571M|COL11A1_ENST00000370096.3_Missense_Mutation_p.L1610M|COL11A1_ENST00000512756.1_Missense_Mutation_p.L1494M	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1610	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGAGTTGCAGGTCTTTACAA	0.438000													12	141					0.00136819	0.00230257	0.001368	1	0
ELTD1	64123	broad.mit.edu	37	1	79404939	79404939	+	Silent	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:79404939A>G	ENST00000370742.3	-	4	393	c.330T>C	c.(328-330)aaT>aaC	p.N110N		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	110					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTGCATTCACATTTTCTGTAA	0.244000													16	27					0	0	0.000743	0	0
MAGI2	9863	broad.mit.edu	37	7	77764519	77764519	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:77764519C>A	ENST00000354212.4	-	17	3103	c.2850G>T	c.(2848-2850)gtG>gtT	p.V950V	MAGI2_ENST00000419488.1_Silent_p.V936V|MAGI2_ENST00000522391.1_Silent_p.V950V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	950	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TTTTATGGGGCACAGCTAAAA	0.458000													7	64					0.000157383	0.000281541	0.003080	1	0
DNAH9	1770	broad.mit.edu	37	17	11809074	11809074	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:11809074G>A	ENST00000262442.3	+	61	11765	c.11697G>A	c.(11695-11697)atG>atA	p.M3899I	DNAH9_ENST00000396001.2_Missense_Mutation_p.M211I|DNAH9_ENST00000454412.2_Missense_Mutation_p.M3899I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3899	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACTCCTATGTTTTTCATCC	0.498000													7	28					0	0	0.001984	0	0
BCL2L1	598	broad.mit.edu	37	20	30309467	30309467	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:30309467G>A	ENST00000307677.4	-	2	965	c.555C>T	c.(553-555)aaC>aaT	p.N185N	BCL2L1_ENST00000376062.2_Silent_p.N185N|BCL2L1_ENST00000420653.1_Silent_p.N185N|BCL2L1_ENST00000376055.4_Intron	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	185					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CCCAGCCGCCGTTCTCCTGGA	0.522000													9	81					0	0	0.004482	0	0
USP26	83844	broad.mit.edu	37	X	132160157	132160157	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:132160157G>A	ENST00000511190.1	-	6	2561	c.2092C>T	c.(2092-2094)Cga>Tga	p.R698*	USP26_ENST00000406273.1_Nonsense_Mutation_p.R698*|USP26_ENST00000370832.1_Nonsense_Mutation_p.R698*	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	698					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					TATTTCTTTCGTTTTGGATTT	0.383000													7	57					0	0	0.003080	0	0
NOP9	161424	broad.mit.edu	37	14	24774178	24774178	+	Silent	SNP	C	C	T	rs138357845	byFrequency	TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:24774178C>T	ENST00000267425.3	+	10	1881	c.1788C>T	c.(1786-1788)ttC>ttT	p.F596F	NOP9_ENST00000396802.3_3'UTR	NM_174913.1	NP_777573.1			NOP9 nucleolar protein																		GAGACCCTTTCGGCCACCATG	0.547000													5	44					0	0	0.001168	0	0
ZBTB41	360023	broad.mit.edu	37	1	197168484	197168484	+	Splice_Site	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:197168484C>T	ENST00000367405.4	-	1	1188	c.1120_splice	c.e1+1	p.G374_splice	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CTTTTCTTACCTATTCGGTCA	0.308000													4	39					0	0	0.000248	0	0
CSTF3	1479	broad.mit.edu	37	11	33108570	33108570	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:33108570G>A	ENST00000323959.4	-	18	1898	c.1759C>T	c.(1759-1761)Cag>Tag	p.Q587*	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	587	Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ATCATCTGCTGAGTGTCTGGT	0.428000													12	182					0	0	0.001368	0	0
ABCA12	26154	broad.mit.edu	37	2	215838676	215838676	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:215838676G>C	ENST00000272895.7	-	36	5778	c.5559C>G	c.(5557-5559)gtC>gtG	p.V1853V	ABCA12_ENST00000389661.4_Silent_p.V1535V	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1853					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATCTTACCTGGACATTTTCTG	0.383000													9	45					0	0	0.004482	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057896	46057896	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:46057896T>A	ENST00000380095.1	+	1	624	c.562T>A	c.(562-564)Tcc>Acc	p.S188T	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	188	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						CAGACCCTCCTCCTCCGTGTC	0.662000													8	164					0	0	0.004482	0	0
TFAP2E	339488	broad.mit.edu	37	1	36054008	36054008	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:36054008C>A	ENST00000373235.3	+	4	848	c.640C>A	c.(640-642)Cct>Act	p.P214T		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	214						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CATCACAAATCCTGGTGAGGT	0.627000													7	80					5.4927e-09	1.16359e-08	0.004482	1	0
ZNF614	80110	broad.mit.edu	37	19	52519665	52519665	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:52519665C>G	ENST00000270649.6	-	5	1730	c.1186G>C	c.(1186-1188)Gaa>Caa	p.E396Q	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TAAGATTTTTCTCCTGTGTGG	0.433000													23	124					0	0	0.003330	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230332	140230332	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:140230332C>A	ENST00000378122.3	+	1	2976	c.2252C>A	c.(2251-2253)tCg>tAg	p.S751*	PCDHA9_ENST00000532602.1_Nonsense_Mutation_p.S751*|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCGTACTCGCAGCAGAGG	0.642000													10	71					3.07112e-06	5.98125e-06	0.000978	1	0
RYR1	6261	broad.mit.edu	37	19	39018978	39018978	+	Silent	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:39018978G>T	ENST00000355481.4	+	73	10973	c.10842G>T	c.(10840-10842)gtG>gtT	p.V3614V	RYR1_ENST00000360985.3_Silent_p.V3619V|AC067969.1_ENST00000597015.1_RNA|RYR1_ENST00000359596.3_Silent_p.V3619V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3619					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGAAGGCCGTGTGGCACAAGC	0.612000													4	35					0.000602214	0.00103512	0.000602	1	0
NDST4	64579	broad.mit.edu	37	4	115856489	115856489	+	Splice_Site	SNP	A	A	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:115856489A>T	ENST00000264363.2	-	6	2087	c.1407_splice	c.e6-1	p.V470_splice		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	470	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCGAGGGAGGACCTGAGTAAA	0.393000													5	23					0	0	0.000602	0	0
OR1A2	26189	broad.mit.edu	37	17	3101596	3101596	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:3101596C>A	ENST00000381951.1	+	1	784	c.784C>A	c.(784-786)Ctg>Atg	p.L262M		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						TTTCCGCCCTCTGACCAGTTA	0.433000													17	76					4.14922e-12	9.15101e-12	0.004007	1	0
CLSTN3	9746	broad.mit.edu	37	12	7288024	7288024	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:7288024G>A	ENST00000537408.1	+	3	1059	c.521G>A	c.(520-522)cGc>cAc	p.R174H	CLSTN3_ENST00000266546.6_Missense_Mutation_p.R162H			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	162	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CTGTACGATCGCATCCTGCGG	0.562000													5	49					0	0	0.000602	0	0
SDHAP1	255812	broad.mit.edu	37	3	195710993	195710993	+	RNA	SNP	A	A	G	rs4927692	by1000genomes	TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:195710993A>G	ENST00000427841.1	-	0	739					NR_003264.2																						CCTCCCGTATAAGGTGTGCAA	0.617000													4	29					0	0	0.001168	0	0
RBM6	10180	broad.mit.edu	37	3	50095202	50095202	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:50095202C>G	ENST00000443081.1	+	9	2258	c.1339C>G	c.(1339-1341)Cag>Gag	p.Q447E	RBM6_ENST00000539992.1_5'UTR|RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000422955.1_Missense_Mutation_p.Q57E|RBM6_ENST00000442092.1_Missense_Mutation_p.Q57E|RBM6_ENST00000266022.4_Missense_Mutation_p.Q579E			P78332	RBM6_HUMAN	RNA binding motif protein 6	579					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CCCTCAGCCTCAGAAAACATC	0.428000													9	82					0	0	0.000443	0	0
TEF	7008	broad.mit.edu	37	22	41783534	41783534	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:41783534A>G	ENST00000266304.4	+	2	453	c.337A>G	c.(337-339)Agc>Ggc	p.S113G	TEF_ENST00000406644.3_Missense_Mutation_p.S83G	NM_003216.3	NP_003207.1	Q10587	TEF_HUMAN	thyrotrophic embryonic factor	113					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						CATCCCCGCCAGCCCCACCCA	0.592000													14	102					0	0	0.003163	0	0
USP29	57663	broad.mit.edu	37	19	57641440	57641440	+	Missense_Mutation	SNP	C	C	A	rs137993626		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:57641440C>A	ENST00000254181.4	+	4	1851	c.1397C>A	c.(1396-1398)cCt>cAt	p.P466H	USP29_ENST00000598197.1_Missense_Mutation_p.P466H	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	466					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACCACTTCCTTTGTCCATT	0.378000													19	68					8.00594e-06	1.54059e-05	0.000958	1	0
TNN	63923	broad.mit.edu	37	1	175116197	175116197	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:175116197G>A	ENST00000239462.4	+	19	4003	c.3890G>A	c.(3889-3891)cGa>cAa	p.R1297Q		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1297					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGAAGGCTGCGAACGTTCTGA	0.602000											OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	25					0	0	0.000443	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111956512	111956512	+	Silent	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:111956512G>T	ENST00000374566.3	-	21	2728	c.2211C>A	c.(2209-2211)tcC>tcA	p.S737S		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	737						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGGCCCCAGGGGACAGCAGGC	0.572000													10	89					1.58986e-06	3.14715e-06	0.000673	1	0
MX1	4599	broad.mit.edu	37	21	42830502	42830502	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:42830502C>T	ENST00000398600.2	+	19	2831	c.1806C>T	c.(1804-1806)ttC>ttT	p.F602F	MX1_ENST00000398598.3_Silent_p.F602F|MX1_ENST00000288383.6_Silent_p.F579F|MX1_ENST00000455164.2_Silent_p.F602F	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	602	GED.				induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				TCATCCAGTTCTTCATGCTCC	0.592000													12	177					0	0	0.001368	0	0
NUP210L	91181	broad.mit.edu	37	1	153974274	153974274	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:153974274G>T	ENST00000368559.3	-	36	5189	c.5118C>A	c.(5116-5118)agC>agA	p.S1706R	NUP210L_ENST00000271854.3_Intron|NUP210L_ENST00000368553.1_Intron	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1706						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CTTGTTTGTGGCTAAGAACCA	0.428000													13	205					0.00185496	0.00310015	0.001855	1	0
RRP12	23223	broad.mit.edu	37	10	99144961	99144961	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:99144961C>A	ENST00000370992.4	-	10	1281	c.1170G>T	c.(1168-1170)tgG>tgT	p.W390C	RRP12_ENST00000315563.6_Missense_Mutation_p.W290C|RRP12_ENST00000536831.1_Missense_Mutation_p.W108C|RRP12_ENST00000414986.1_Missense_Mutation_p.W329C	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	390						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TGACCTTAAGCCAGGCTAGCA	0.537000													19	77					8.34094e-07	1.66474e-06	0.001216	1	0
DKC1	1736	broad.mit.edu	37	X	153996698	153996698	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:153996698G>C	ENST00000369550.5	+	8	972	c.762G>C	c.(760-762)atG>atC	p.M254I		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	254					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTGGAGTCATGAGTGAAAAGG	0.493000									Congenital Dyskeratosis				21	93					0	0	0.002299	0	0
ZAN	7455	broad.mit.edu	37	7	100359846	100359846	+	RNA	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:100359846C>A	ENST00000542585.1	+	0	3999				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGCACATACTCTGGCAAACTC	0.577000													9	38					3.09899e-07	6.28912e-07	0.004482	1	0
VWA3B	200403	broad.mit.edu	37	2	98887340	98887340	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:98887340G>A	ENST00000477737.1	+	22	3243	c.3039G>A	c.(3037-3039)ccG>ccA	p.P1013P	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1013										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ACAAGGCCCCGGGAGAGGTGG	0.532000													9	60					0	0	0.004482	0	0
OR8B2	26595	broad.mit.edu	37	11	124252802	124252802	+	Silent	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:124252802A>G	ENST00000375013.2	-	1	456	c.438T>C	c.(436-438)ttT>ttC	p.F146F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGTAAGCAGCAAAAGTGAGCA	0.468000													3	19					0	0	0.004672	0	0
TRIM22	10346	broad.mit.edu	37	11	5717615	5717615	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:5717615A>C	ENST00000379965.3	+	2	430	c.153A>C	c.(151-153)agA>agC	p.R51S	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	51					immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TCATCTCAAGAGGGGAAAGCA	0.532000													4	49					0	0	0.000248	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69337200	69337200	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:69337200G>T	ENST00000305363.4	+	5	413	c.349G>T	c.(349-351)Gct>Tct	p.A117S		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	117	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TGGAGTGTTGGCTCATATGCT	0.398000													24	195					3.01185e-09	6.43683e-09	0.003954	1	0
ZNF536	9745	broad.mit.edu	37	19	30935893	30935893	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:30935893G>A	ENST00000355537.3	+	2	1571	c.1424G>A	c.(1423-1425)aGc>aAc	p.S475N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCCATCTCCAGCATGGCCCAC	0.657000													5	46					0	0	0.000602	0	0
FREM1	158326	broad.mit.edu	37	9	14747282	14747282	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:14747282C>T	ENST00000380881.4	-	34	6807	c.5992G>A	c.(5992-5994)Gac>Aac	p.D1998N	FREM1_ENST00000422223.2_Missense_Mutation_p.D1997N|FREM1_ENST00000380880.3_Missense_Mutation_p.D1997N|FREM1_ENST00000380894.1_Missense_Mutation_p.D533N			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1997					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAGTGTGAGTCAGTTGTGGAT	0.408000													16	147					0	0	0.000743	0	0
SV2A	9900	broad.mit.edu	37	1	149885253	149885253	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:149885253G>C	ENST00000369146.3	-	2	630	c.140C>G	c.(139-141)tCc>tGc	p.S47C	SV2A_ENST00000369145.1_Missense_Mutation_p.S47C	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	47	Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTCAAAGCGGGAGTACGATCT	0.537000													35	72					0	0	0.005524	0	0
PRIMA1	145270	broad.mit.edu	37	14	94187833	94187833	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:94187833G>A	ENST00000393140.1	-	5	521	c.419C>T	c.(418-420)tCg>tTg	p.S140L	PRIMA1_ENST00000316227.3_3'UTR|PRIMA1_ENST00000393143.1_Missense_Mutation_p.S140L	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	140					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GTTGCTCTGCGAAGCACTCAT	0.577000													4	48					0	0	0.000602	0	0
CENPF	1063	broad.mit.edu	37	1	214813858	214813858	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:214813858C>G	ENST00000366955.3	+	12	2345	c.2177C>G	c.(2176-2178)tCt>tGt	p.S726C		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	726					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTGAAGACTTCTCAGCTTACT	0.403000													8	41					0	0	0.004482	0	0
OR4C15	81309	broad.mit.edu	37	11	55322726	55322726	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:55322726C>A	ENST00000314644.2	+	1	944	c.944C>A	c.(943-945)cCa>cAa	p.P315Q		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						ACACGACCTCCATCTGCTTTT	0.393000										HNSCC(20;0.049)			11	136					2.80697e-09	6.02564e-09	0.000978	1	0
CDH12	1010	broad.mit.edu	37	5	21755753	21755753	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:21755753C>T	ENST00000382254.1	-	14	2918	c.1832G>A	c.(1831-1833)gGa>gAa	p.G611E	CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Missense_Mutation_p.G571E|RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Missense_Mutation_p.G611E	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	611					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G611E(1)		NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AGTGCTAAGTCCTACAGGTAG	0.398000										HNSCC(59;0.17)			11	52					0	0	0.000673	0	0
F11R	50848	broad.mit.edu	37	1	160990842	160990842	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:160990842C>G	ENST00000368026.6	-	1	296	c.22G>C	c.(22-24)Gag>Cag	p.E8Q	F11R_ENST00000289779.3_3'UTR|F11R_ENST00000537746.1_Missense_Mutation_p.E8Q	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	8					blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			AGTTTCCTCTCGACTTGCGCC	0.577000													7	44					0	0	0.001368	0	0
CHST6	4166	broad.mit.edu	37	16	75512953	75512953	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:75512953G>C	ENST00000332272.4	-	3	953	c.774C>G	c.(772-774)ctC>ctG	p.L258L	CHST6_ENST00000390664.2_Silent_p.L258L|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	258					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GTGGCGGCTTGAGTGTGGCGG	0.711000													4	33					0	0	0.000248	0	0
TSC22D4	81628	broad.mit.edu	37	7	100074925	100074925	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:100074925A>T	ENST00000300181.2	-	2	1491	c.737T>A	c.(736-738)tTg>tAg	p.L246*	TSC22D4_ENST00000496728.1_5'UTR|TSC22D4_ENST00000393991.1_Nonsense_Mutation_p.L7*	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	246					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGAGCACCCAACTCCATCCG	0.637000													16	76					0	0	0.004990	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062081	66062081	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:66062081G>T	ENST00000327259.4	+	2	508	c.364G>T	c.(364-366)Gtg>Ttg	p.V122L		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	122						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						GCACTGTCACGTGCGGTCCTG	0.697000													3	13					0.004672	0.007728	0.004672	1	0
SRGAP3	9901	broad.mit.edu	37	3	9100091	9100091	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:9100091G>C	ENST00000383836.3	-	7	1294	c.867C>G	c.(865-867)taC>taG	p.Y289*	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Nonsense_Mutation_p.Y289*	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	289					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCTCCAGGTTGTATTCAGCTG	0.547000			T	RAF1	pilocytic astrocytoma								4	113					0	0	0.001168	0	0
OR6K2	81448	broad.mit.edu	37	1	158669964	158669964	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:158669964G>A	ENST00000359610.2	-	1	522	c.479C>T	c.(478-480)gCc>gTc	p.A160V		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					AGAGATCCAGGCAATCTCAGG	0.493000													24	50					0	0	0.003330	0	0
GPR124	25960	broad.mit.edu	37	8	37687465	37687465	+	Silent	SNP	C	C	G	rs137891322		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:37687465C>G	ENST00000315215.7	+	6	1014	c.651C>G	c.(649-651)ctC>ctG	p.L217L	GPR124_ENST00000412232.2_Silent_p.L217L			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	217	LRRCT.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			AACACACGCTCTGTGCTTACC	0.662000													4	28					0	0	0.000248	0	0
RINL	126432	broad.mit.edu	37	19	39360303	39360303	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:39360303C>T	ENST00000340740.3	-	10	1429	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	RINL_ENST00000591812.1_Missense_Mutation_p.E462K|RINL_ENST00000598904.1_Missense_Mutation_p.E348K	NM_001195833.1|NM_198445.3	NP_001182762.1|NP_940847.1	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	348	VPS9.						GTPase activator activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|urinary_tract(2)	17						CAGATGAGTTCCTCGGTCAGC	0.607000											OREG0025454	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	60					0	0	0.000248	0	0
FMNL1	752	broad.mit.edu	37	17	43311087	43311087	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:43311087G>C	ENST00000331495.3	+	5	810	c.474G>C	c.(472-474)caG>caC	p.Q158H	FMNL1_ENST00000592006.1_3'UTR|FMNL1_ENST00000328118.3_Missense_Mutation_p.Q158H	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	158	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						CCTTTGCCCAGTGCTCTGTCA	0.617000													4	49					0	0	0.000248	0	0
ELFN2	114794	broad.mit.edu	37	22	37769903	37769903	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:37769903C>A	ENST00000402918.1	-	3	2457	c.1672G>T	c.(1672-1674)Gac>Tac	p.D558Y	ELFN2_ENST00000349653.3_Missense_Mutation_p.D558Y|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	558						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					GAGGCCGAGTCCAGCTTGAGA	0.622000													8	71					1.12685e-05	2.12605e-05	0.004482	1	0
VMA21	203547	broad.mit.edu	37	X	150573509	150573509	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:150573509G>T	ENST00000330374.6	+	3	390	c.285G>T	c.(283-285)tgG>tgT	p.W95C	VMA21_ENST00000477649.1_3'UTR|VMA21_ENST00000370361.1_Missense_Mutation_p.W150C	NM_001017980.3	NP_001017980.1	Q3ZAQ7	VMA21_HUMAN	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)	95					vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	7						CACGACAGTGGCGTGAAGGCA	0.438000													9	32					2.17888e-05	4.06331e-05	0.000443	1	0
PRDM9	56979	broad.mit.edu	37	5	23523430	23523430	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:23523430G>C	ENST00000296682.3	+	9	1095	c.913G>C	c.(913-915)Gtg>Ctg	p.V305L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	305	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CTATGAGTATGTGGATGGAAA	0.423000										HNSCC(3;0.000094)			8	83					0	0	0.004482	0	0
SAMD9	54809	broad.mit.edu	37	7	92734035	92734035	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:92734035C>A	ENST00000379958.2	-	3	1645	c.1376G>T	c.(1375-1377)cGa>cTa	p.R459L		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	459						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTTGCTACTCGGCTTTCTTT	0.378000													6	46					0.00116845	0.00197328	0.001168	1	0
FAM71B	153745	broad.mit.edu	37	5	156593047	156593047	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:156593047G>C	ENST00000302938.4	-	1	228	c.133C>G	c.(133-135)Cca>Gca	p.P45A		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	45						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCGAACATTGGTGCATACTTG	0.453000													9	92					0	0	0.004482	0	0
KEAP1	9817	broad.mit.edu	37	19	10610364	10610364	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:10610364G>A	ENST00000171111.5	-	2	893	c.346C>T	c.(346-348)Cgg>Tgg	p.R116W	KEAP1_ENST00000393623.2_Missense_Mutation_p.R116W	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	116	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCCTGCTCCCGCAGCCCGTTG	0.612000													5	37					0	0	0.000602	0	0
HAS2	3037	broad.mit.edu	37	8	122626832	122626832	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:122626832G>C	ENST00000303924.4	-	4	1713	c.1176C>G	c.(1174-1176)gcC>gcG	p.A392A		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	392						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GGATTACTGTGGCAATGAGAA	0.418000													14	101					0	0	0.001855	0	0
ADAM29	11086	broad.mit.edu	37	4	175898063	175898063	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:175898063G>T	ENST00000359240.3	+	5	2057	c.1387G>T	c.(1387-1389)Gat>Tat	p.D463Y	ADAM29_ENST00000445694.1_Missense_Mutation_p.D463Y|ADAM29_ENST00000514159.1_Missense_Mutation_p.D463Y|ADAM29_ENST00000404450.4_Missense_Mutation_p.D463Y	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	463	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CAATGAATGTGATCTTCCAGA	0.448000													5	74					5.9392e-07	1.19526e-06	0.001168	1	0
FCRL3	115352	broad.mit.edu	37	1	157659641	157659641	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:157659641A>G	ENST00000368184.3	-	10	2048	c.1757T>C	c.(1756-1758)gTc>gCc	p.V586A	FCRL3_ENST00000368186.5_Missense_Mutation_p.V586A|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	586						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AGCAGCAAGGACGAGGATGCT	0.562000													5	47					0	0	0.001168	0	0
TAF1C	9013	broad.mit.edu	37	16	84212974	84212974	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:84212974C>T	ENST00000567759.1	-	14	2365	c.2183G>A	c.(2182-2184)cGa>cAa	p.R728Q	TAF1C_ENST00000378541.4_Missense_Mutation_p.R728Q|TAF1C_ENST00000566732.1_Missense_Mutation_p.R702Q|TAF1C_ENST00000341690.6_Missense_Mutation_p.R634Q|TAF1C_ENST00000541676.1_Missense_Mutation_p.R635Q|TAF1C_ENST00000570117.1_Missense_Mutation_p.R396Q	NM_005679.3	NP_005670.3	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	728					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						GGCAGCCCCTCGGCCTGCCCA	0.706000													5	28					0	0	0.000602	0	0
C2orf53	339779	broad.mit.edu	37	2	27360923	27360923	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:27360923G>T	ENST00000335524.3	-	3	800	c.275C>A	c.(274-276)cCa>cAa	p.P92Q		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	92	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGGGAACTTGGGAGAGAGGG	0.572000													5	36					0.000602214	0.00103512	0.000602	1	0
PIGO	84720	broad.mit.edu	37	9	35095173	35095173	+	Silent	SNP	G	G	A	rs139962374		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:35095173G>A	ENST00000378617.3	-	2	784	c.390C>T	c.(388-390)acC>acT	p.T130T	PIGO_ENST00000361778.2_Silent_p.T130T|PIGO_ENST00000341666.3_Silent_p.T130T|PIGO_ENST00000298004.5_Silent_p.T130T|PIGO_ENST00000492770.1_5'UTR	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	130					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTGCATGGTGGTGGTAGGAG	0.567000													9	56					0	0	0.000443	0	0
POP5	51367	broad.mit.edu	37	12	121018963	121018963	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:121018963C>G	ENST00000341039.2	-	2	134	c.118G>C	c.(118-120)Gtg>Ctg	p.V40L	POP5_ENST00000357500.4_Missense_Mutation_p.V40L|POP5_ENST00000542776.1_5'UTR	NM_198202.1	NP_937845.1	Q969H6	POP5_HUMAN	processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)	40					tRNA processing		protein binding|ribonuclease P activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					GTTCCGTGCACCCTGGCGATC	0.672000													5	69					0	0	0.001168	0	0
PEG3	5178	broad.mit.edu	37	19	57335782	57335782	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:57335782G>T	ENST00000326441.9	-	4	605	c.242C>A	c.(241-243)aCc>aAc	p.T81N	ZIM2_ENST00000391708.3_5'UTR|ZIM2_ENST00000221722.5_5'UTR|PEG3_ENST00000423103.2_Missense_Mutation_p.T81N|PEG3_ENST00000593695.1_5'UTR|ZIM2_ENST00000599935.1_5'UTR|PEG3_ENST00000598410.1_5'UTR|ZIM2_ENST00000593711.1_5'UTR|PEG3_ENST00000594706.1_5'UTR|ZIM2_ENST00000601070.1_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	81	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTCCTCCTTGGTGCGGGTCTC	0.527000													8	68					0.000274275	0.000481727	0.004482	1	0
SNTG1	54212	broad.mit.edu	37	8	51617187	51617187	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:51617187C>G	ENST00000522124.1	+	16	1727	c.1066C>G	c.(1066-1068)Cag>Gag	p.Q356E	SNTG1_ENST00000517473.1_Missense_Mutation_p.Q356E|SNTG1_ENST00000276467.5_Missense_Mutation_p.Q356E|SNTG1_ENST00000518864.1_Missense_Mutation_p.Q356E	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	356	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CCGACGGAAACAGTGCTTCAC	0.552000													4	95					0	0	0.000248	0	0
MYT1L	23040	broad.mit.edu	37	2	1926775	1926775	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:1926775C>T	ENST00000399161.2	-	10	1513	c.766G>A	c.(766-768)Gat>Aat	p.D256N	MYT1L_ENST00000428368.2_Missense_Mutation_p.D256N	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	256					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTAACAACATCACTGTCTAAG	0.413000													12	137					0	0	0.001368	0	0
SNX5	27131	broad.mit.edu	37	20	17934694	17934694	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:17934694C>T	ENST00000377768.3	-	5	647	c.335G>A	c.(334-336)gGt>gAt	p.G112D	SNX5_ENST00000483485.1_5'UTR|SNX5_ENST00000377759.4_Missense_Mutation_p.G112D	NM_152227.1	NP_689413.1	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	112	PX.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	11						AGACCCTTCACCTTCTCCCAG	0.478000													10	135					0	0	0.000673	0	0
NEK9	91754	broad.mit.edu	37	14	75555296	75555296	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:75555296G>C	ENST00000238616.5	-	20	2649	c.2491C>G	c.(2491-2493)Ctc>Gtc	p.L831V		NM_033116.4	NP_149107.4	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	831	Interaction with NEK6.|Pro/Ser/Thr-rich.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GCTGCACTGAGAGGAGATGGG	0.458000											OREG0022811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	55					0	0	0.001984	0	0
COL3A1	1281	broad.mit.edu	37	2	189861944	189861944	+	Splice_Site	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:189861944G>A	ENST00000304636.3	+	25	1985	c.1815_splice	c.e25+1	p.Q605_splice	COL3A1_ENST00000317840.5_Splice_Site_p.Q605_splice	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	605	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGGCCCTCAGGTACGTAGCT	0.443000													10	61					0	0	0.000673	0	0
UPK1A	11045	broad.mit.edu	37	19	36159427	36159427	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:36159427G>A	ENST00000222275.2	+	2	156	c.156G>A	c.(154-156)atG>atA	p.M52I	UPK1A_ENST00000379013.2_Missense_Mutation_p.M52I|UPK1A-AS1_ENST00000443196.1_RNA	NM_007000.2	NP_008931.1	O00322	UPK1A_HUMAN	uroplakin 1A	52					epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity			breast(1)|large_intestine(4)|lung(2)|stomach(2)	9	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACCCACTGATGGGAGTCTCAG	0.567000													7	43					0	0	0.003080	0	0
OR8H1	219469	broad.mit.edu	37	11	56057972	56057972	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:56057972C>A	ENST00000313022.2	-	1	594	c.567G>T	c.(565-567)atG>atT	p.M189I		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M189I(1)		NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					CGTATGTGTCCATGCAGGACA	0.428000													11	78					1.08611e-07	2.24184e-07	0.000978	1	0
POLR2J	5439	broad.mit.edu	37	7	102119268	102119268	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:102119268C>G	ENST00000292614.5	-	1	86	c.40G>C	c.(40-42)Gag>Cag	p.E14Q	POLR2J_ENST00000393794.3_Missense_Mutation_p.E14Q	NM_006234.4	NP_006225.1	P52435	RPB11_HUMAN	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	14					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|LRR domain binding|protein dimerization activity			pancreas(2)	2						TTCTCGCCCTCGAAGAGCAAG	0.692000											OREG0018232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	30					0	0	0.000248	0	0
DAB2	1601	broad.mit.edu	37	5	39376765	39376765	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:39376765C>T	ENST00000320816.6	-	12	2591	c.2124G>A	c.(2122-2124)ttG>ttA	p.L708L	DAB2_ENST00000509337.1_Silent_p.L687L|DAB2_ENST00000339788.6_Silent_p.L490L|DAB2_ENST00000545653.1_Silent_p.L687L	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	708	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			TGATCTTGTTCAATAGTTGAT	0.453000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	72					0	0	0.003080	0	0
USP29	57663	broad.mit.edu	37	19	57641439	57641439	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:57641439C>A	ENST00000254181.4	+	4	1850	c.1396C>A	c.(1396-1398)Cct>Act	p.P466T	USP29_ENST00000598197.1_Missense_Mutation_p.P466T	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	466					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAACCACTTCCTTTGTCCAT	0.383000													19	68					8.00594e-06	1.54059e-05	0.000958	1	0
AADACL4	343066	broad.mit.edu	37	1	12726279	12726279	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:12726279C>G	ENST00000376221.1	+	4	757	c.757C>G	c.(757-759)Ctg>Gtg	p.L253V		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	253						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGTGACTTCTCTGTGTAACTA	0.498000													12	144					0	0	0.001855	0	0
SLC18A2	6571	broad.mit.edu	37	10	119003520	119003520	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:119003520G>C	ENST00000298472.5	+	3	303	c.160G>C	c.(160-162)Gag>Cag	p.E54Q	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	54					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CATTAAGCATGAGAAGAATGC	0.478000													4	32					0	0	0.000248	0	0
ACRC	93953	broad.mit.edu	37	X	70823587	70823587	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:70823587G>C	ENST00000373695.1	+	7	997	c.460G>C	c.(460-462)Gat>Cat	p.D154H	ACRC_ENST00000373696.3_Missense_Mutation_p.D154H			Q96QF7	ACRC_HUMAN	acidic repeat containing	154	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CGACAACAGTGATGATTCGGA	0.463000													14	110					0	0	0.004007	0	0
CDH17	1015	broad.mit.edu	37	8	95182647	95182647	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:95182647C>A	ENST00000027335.3	-	9	1168	c.1044G>T	c.(1042-1044)gaG>gaT	p.E348D	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Missense_Mutation_p.E348D	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	348	Cadherin 4.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCTCCTGGACCTCAAATACGG	0.433000													5	76					0.00116845	0.00197328	0.001168	1	0
DMXL2	23312	broad.mit.edu	37	15	51837821	51837821	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:51837821G>A	ENST00000251076.5	-	8	1176	c.889C>T	c.(889-891)Cat>Tat	p.H297Y	DMXL2_ENST00000543779.2_Missense_Mutation_p.H297Y|DMXL2_ENST00000449909.3_Missense_Mutation_p.H297Y	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	297						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CTTCCAGCATGAGAAAGGCTG	0.413000													12	104					0	0	0.001368	0	0
CADPS	8618	broad.mit.edu	37	3	62543142	62543142	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:62543142G>A	ENST00000383710.4	-	10	2040	c.1691C>T	c.(1690-1692)gCg>gTg	p.A564V	CADPS_ENST00000357948.3_Missense_Mutation_p.A564V|CADPS_ENST00000283269.9_Missense_Mutation_p.A564V	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	564	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTGAGGCTCCGCTTTCTTCTC	0.537000													16	147					0	0	0.000743	0	0
ANXA6	309	broad.mit.edu	37	5	150501775	150501775	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:150501775C>T	ENST00000354546.5	-	17	1507	c.1280G>A	c.(1279-1281)aGg>aAg	p.R427K	ANXA6_ENST00000523714.1_Missense_Mutation_p.R395K|ANXA6_ENST00000521512.1_Missense_Mutation_p.R220K|ANXA6_ENST00000356496.5_Missense_Mutation_p.R427K|ANXA6_ENST00000377751.5_Missense_Mutation_p.R84K	NM_001155.4	NP_001146.2	P08133	ANXA6_HUMAN	annexin A6	427						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding			endometrium(2)|kidney(1)|lung(9)	12		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGAATCAGCCTTGCCAGGTC	0.552000													4	15					0	0	0.000248	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179564898	179564898	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:179564898G>T	ENST00000393371.2	-	1	451	c.155C>A	c.(154-156)cCc>cAc	p.P52H	RASGEF1C_ENST00000361132.4_Missense_Mutation_p.P52H			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	52	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTCGGCTGTGGGCACCAGGTG	0.677000													6	25					8.12818e-05	0.000147038	0.001984	1	0
ZC3H4	23211	broad.mit.edu	37	19	47570385	47570385	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:47570385G>A	ENST00000253048.5	-	15	3177	c.3140C>T	c.(3139-3141)tCt>tTt	p.S1047F	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1047							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GAGGATGCGAGACAGAAGTTC	0.706000													4	20					0	0	0.000248	0	0
ZHX3	23051	broad.mit.edu	37	20	39832452	39832452	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:39832452C>G	ENST00000309060.3	-	4	1520	c.1105G>C	c.(1105-1107)Gag>Cag	p.E369Q	ZHX3_ENST00000540170.1_Missense_Mutation_p.E369Q|ZHX3_ENST00000560361.1_Missense_Mutation_p.E369Q|ZHX3_ENST00000432768.2_Missense_Mutation_p.E369Q|ZHX3_ENST00000559234.1_Missense_Mutation_p.E369Q|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000544979.2_Missense_Mutation_p.E369Q			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	369	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				CGGGCATCCTCAATCTCCTCA	0.507000													8	69					0	0	0.003080	0	0
ANGEL2	90806	broad.mit.edu	37	1	213181745	213181745	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:213181745C>T	ENST00000366962.3	-	3	603	c.449G>A	c.(448-450)gGa>gAa	p.G150E	ANGEL2_ENST00000535388.1_5'UTR|ANGEL2_ENST00000360506.2_5'UTR|ANGEL2_ENST00000540642.1_Missense_Mutation_p.G24E|ANGEL2_ENST00000544555.1_5'UTR	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	150										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		ATTTTTGTCTCCTAGGATCTT	0.318000													4	67					0	0	0.000248	0	0
LRP2	4036	broad.mit.edu	37	2	170096037	170096037	+	Splice_Site	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:170096037C>A	ENST00000263816.3	-	26	4579	c.4294_splice	c.e26+1	p.A1432_splice		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1432					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAGCAATTACCTGTAACTTTG	0.423000													13	64					3.35478e-16	7.50165e-16	0.003163	1	0
PFKL	5211	broad.mit.edu	37	21	45738472	45738472	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:45738472G>A	ENST00000403390.1	+	11	1197	c.1197G>A	c.(1195-1197)gtG>gtA	p.V399V	PFKL_ENST00000349048.4_Silent_p.V352V			P17858	K6PL_HUMAN	phosphofructokinase, liver	352					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		TGGAGTGCGTGCAGATGGTAA	0.697000													6	24					0	0	0.003080	0	0
FYCO1	79443	broad.mit.edu	37	3	46009515	46009515	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:46009515C>T	ENST00000296137.2	-	8	1516	c.1311G>A	c.(1309-1311)ctG>ctA	p.L437L	FYCO1_ENST00000535325.1_Silent_p.L437L	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	437					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CATCCTCTTTCAGCTGAAGCT	0.602000													16	239					0	0	0.003163	0	0
AKAP6	9472	broad.mit.edu	37	14	33292180	33292180	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:33292180C>T	ENST00000280979.4	+	13	5331	c.5161C>T	c.(5161-5163)Cgt>Tgt	p.R1721C	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1721					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTTCAGGAAGCGTCTGACTCG	0.458000													5	82					0	0	0.001984	0	0
GEMIN8	54960	broad.mit.edu	37	X	14027091	14027091	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:14027091C>A	ENST00000380523.4	-	5	988	c.670G>T	c.(670-672)Gac>Tac	p.D224Y	GEMIN8_ENST00000398355.3_Missense_Mutation_p.D224Y	NM_017856.2	NP_060326.1	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	224					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	9						CAGTGCTTGTCAAAGCTCAGC	0.602000													11	49					3.86212e-05	7.0128e-05	0.000673	1	0
PARVG	64098	broad.mit.edu	37	22	44602295	44602295	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:44602295G>T	ENST00000422871.1	+	14	1409	c.985G>T	c.(985-987)Gcc>Tcc	p.A329S	PARVG_ENST00000415224.1_Missense_Mutation_p.A329S|PARVG_ENST00000444313.2_Missense_Mutation_p.A329S	NM_001137605.1	NP_001131077.1	Q9HBI0	PARVG_HUMAN	parvin, gamma	329					cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				GCCCCATGGAGCCCCGAATTG	0.607000													9	40					0.000442599	0.000771753	0.000443	1	0
EIF3L	51386	broad.mit.edu	37	22	38274173	38274173	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:38274173G>C	ENST00000412331.2	+	11	2152	c.1570G>C	c.(1570-1572)Gat>Cat	p.D524H	EIF3L_ENST00000381683.6_Missense_Mutation_p.D476H|EIF3L_ENST00000406934.1_Missense_Mutation_p.D426H	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L	524						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity	p.D524N(1)		kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTTCTACATTGATAAGGTATG	0.453000													8	62					0	0	0.004482	0	0
FREM1	158326	broad.mit.edu	37	9	14808064	14808064	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:14808064G>T	ENST00000380881.4	-	18	3780	c.2965C>A	c.(2965-2967)Cct>Act	p.P989T	FREM1_ENST00000422223.2_Missense_Mutation_p.P988T|FREM1_ENST00000380880.3_Missense_Mutation_p.P988T			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	988					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCACAAAAGGGCCAGCCTCT	0.483000													14	77					3.27435e-08	6.90617e-08	0.002450	1	0
LBX1	10660	broad.mit.edu	37	10	102987542	102987542	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:102987542C>G	ENST00000370193.2	-	2	1309	c.331G>C	c.(331-333)Gac>Cac	p.D111H		NM_006562.4	NP_006553.2	P52954	LBX1_HUMAN	ladybird homeobox 1	111					muscle organ development		sequence-specific DNA binding			large_intestine(2)|lung(4)|ovary(1)	7		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		GTCATACCGTCGCGGCCTGGG	0.612000													5	38					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9047455	9047455	+	Silent	SNP	T	T	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:9047455T>A	ENST00000397910.4	-	5	34379	c.34176A>T	c.(34174-34176)ccA>ccT	p.P11392P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11394	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTTATTGTTGGAAAATCTG	0.453000													21	114					0	0	0.001523	0	0
ENPEP	2028	broad.mit.edu	37	4	111474511	111474511	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:111474511C>G	ENST00000265162.5	+	18	2884	c.2542C>G	c.(2542-2544)Cag>Gag	p.Q848E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	848					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TATTAAAACTCAGGATGTGTT	0.373000													5	80					0	0	0.001168	0	0
TEX15	56154	broad.mit.edu	37	8	30695150	30695150	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:30695150C>T	ENST00000256246.2	-	3	7575	c.7501G>A	c.(7501-7503)Gat>Aat	p.D2501N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2501										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGAGAAACATCAGTTTCTGGG	0.413000													7	68					0	0	0.003080	0	0
UNC13C	440279	broad.mit.edu	37	15	54306933	54306933	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:54306933G>C	ENST00000545554.1	+	1	1833	c.1833G>C	c.(1831-1833)caG>caC	p.Q611H	UNC13C_ENST00000260323.11_Missense_Mutation_p.Q611H|UNC13C_ENST00000537900.1_Missense_Mutation_p.Q611H			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	611					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAGGTGTTCAGGGTATCCAAG	0.502000													21	76					0	0	0.001882	0	0
EIF5A	1984	broad.mit.edu	37	17	7214941	7214941	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:7214941C>G	ENST00000336458.8	+	5	848	c.447C>G	c.(445-447)atC>atG	p.I149M	EIF5A_ENST00000571955.1_Missense_Mutation_p.I149M|EIF5A_ENST00000576930.1_Missense_Mutation_p.I149M|EIF5A_ENST00000416016.2_Missense_Mutation_p.I149M|GPS2_ENST00000391950.3_Intron|EIF5A_ENST00000419711.2_Missense_Mutation_p.I149M|EIF5A_ENST00000572815.1_Missense_Mutation_p.I181M|EIF5A_ENST00000336452.7_Missense_Mutation_p.I179M|EIF5A_ENST00000573542.1_Missense_Mutation_p.I149M	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	149					induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						CTGTTGCAATCAAGGCCATGG	0.502000													3	44					0	0	0.000248	0	0
DDX21	9188	broad.mit.edu	37	10	70741308	70741308	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:70741308G>T	ENST00000354185.4	+	14	2151	c.2053G>T	c.(2053-2055)Gta>Tta	p.V685L		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	685						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TTGCTTTGATGTACCTACCGC	0.308000													7	42					5.4927e-09	1.16359e-08	0.004482	1	0
RRP15	51018	broad.mit.edu	37	1	218504365	218504365	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:218504365G>T	ENST00000366932.3	+	5	811	c.781G>T	c.(781-783)Gac>Tac	p.D261Y		NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	261						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		ATCTATGAAAGACTGGGACAA	0.408000													5	26					3.59834e-05	6.58332e-05	0.001168	1	0
CXCL14	9547	broad.mit.edu	37	5	134914167	134914167	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:134914167C>G	ENST00000337225.5	-	2	627	c.163G>C	c.(163-165)Gaa>Caa	p.E55Q	CXCL14_ENST00000512158.1_Missense_Mutation_p.E43Q|CTC-321K16.1_ENST00000509372.1_RNA	NM_004887.4	NP_004878.2	O95715	CXL14_HUMAN	chemokine (C-X-C motif) ligand 14	55					cell-cell signaling|chemotaxis|immune response|signal transduction	extracellular space|Golgi apparatus	chemokine activity			large_intestine(2)|lung(2)|prostate(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGCTTCATTTCCAGCTTCTTC	0.587000													9	124					0	0	0.004482	0	0
TULP4	56995	broad.mit.edu	37	6	158923470	158923470	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:158923470G>T	ENST00000367097.3	+	13	4132	c.2775G>T	c.(2773-2775)ttG>ttT	p.L925F	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	925					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CTGCCACCTTGAGGCTCACGG	0.677000													6	52					1.12685e-05	2.12605e-05	0.004482	1	0
KRT28	162605	broad.mit.edu	37	17	38955812	38955812	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:38955812C>A	ENST00000306658.7	-	1	399	c.334G>T	c.(334-336)Gct>Tct	p.A112S		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	112	Coil 1A.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				TCTAATTCAGCATTTGCCTCC	0.448000													8	117					4.68919e-08	9.76241e-08	0.000673	1	0
MAGEE2	139599	broad.mit.edu	37	X	75004250	75004250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:75004250G>A	ENST00000373359.2	-	1	829	c.637C>T	c.(637-639)Cag>Tag	p.Q213*		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	213	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TTGATCCTCTGAGGCTTATCC	0.507000													8	33					0	0	0.004482	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130220003	130220003	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:130220003C>T	ENST00000276211.5	+	9	1566	c.1221C>T	c.(1219-1221)caC>caT	p.H407H	ARHGAP36_ENST00000370922.1_Silent_p.H395H|ARHGAP36_ENST00000370921.1_Silent_p.H271H	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	407	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GGATTGATCACTATGTTGCTT	0.448000													31	104					0	0	0.001512	0	0
LSAMP	4045	broad.mit.edu	37	3	115738360	115738360	+	Splice_Site	SNP	A	A	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:115738360A>T	ENST00000490035.1	-	3	1014		c.e3+1		LSAMP_ENST00000539563.1_Splice_Site|LSAMP_ENST00000498645.1_Splice_Site	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein						cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		AGTATTGCTTACCAGTTGGTG	0.458000													6	24					0	0	0.001984	0	0
TRAF6	7189	broad.mit.edu	37	11	36516548	36516548	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:36516548T>C	ENST00000526995.1	-	5	902	c.656A>G	c.(655-657)aAt>aGt	p.N219S	TRAF6_ENST00000529150.1_5'UTR|TRAF6_ENST00000348124.5_Missense_Mutation_p.N219S	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	219	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				GAGTATAGTATTGCAGTATTC	0.264000													5	59					0	0	0.001168	0	0
OR10R2	343406	broad.mit.edu	37	1	158450525	158450525	+	Silent	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:158450525T>C	ENST00000368152.1	+	1	858	c.858T>C	c.(856-858)taT>taC	p.Y286Y	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CAGCAAACTATGTGTCCAACA	0.473000													14	50					0	0	0.003163	0	0
FOLH1	2346	broad.mit.edu	37	11	49176011	49176011	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:49176011G>C	ENST00000340334.7	-	17	1980	c.1612C>G	c.(1612-1614)Cac>Gac	p.H538D	FOLH1_ENST00000356696.3_Missense_Mutation_p.H553D|FOLH1_ENST00000256999.2_Missense_Mutation_p.H553D|FOLH1_ENST00000343844.4_Missense_Mutation_p.H245D|FOLH1_ENST00000533034.1_Missense_Mutation_p.H538D	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	553	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TAGACACTGTGATACAGTGGA	0.363000													4	24					0	0	0.000248	0	0
BRMS1L	84312	broad.mit.edu	37	14	36304127	36304127	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:36304127G>T	ENST00000216807.7	+	4	638	c.439G>T	c.(439-441)Gag>Tag	p.E147*	BRMS1L_ENST00000543183.1_Nonsense_Mutation_p.E99*	NM_032352.3	NP_115728.2	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like	147					regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)		CCAGCATTGTGAGGTACTGTC	0.323000													4	20					0.00024832	0.000440951	0.000248	1	0
RASGEF1C	255426	broad.mit.edu	37	5	179564908	179564908	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:179564908G>C	ENST00000393371.2	-	1	441	c.145C>G	c.(145-147)Cac>Gac	p.H49D	RASGEF1C_ENST00000361132.4_Missense_Mutation_p.H49D			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	49	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCACCAGGTGCTGGATCAGT	0.677000													5	29					0	0	0.000602	0	0
NPVF	64111	broad.mit.edu	37	7	25266592	25266592	+	Silent	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:25266592A>G	ENST00000222674.2	-	2	238	c.192T>C	c.(190-192)gaT>gaC	p.D64D		NM_022150.3	NP_071433.3	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	64					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						TTGGTCCCCAATCTTTTAATT	0.378000													8	101					0	0	0.004482	0	0
SEMA5A	9037	broad.mit.edu	37	5	9237963	9237963	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:9237963A>C	ENST00000382496.5	-	6	975	c.310T>G	c.(310-312)Tgt>Ggt	p.C104G		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	104	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TTGCTGTAACAGGCCTTTTTG	0.378000													6	54					0	0	0.003080	0	0
FOXB1	27023	broad.mit.edu	37	15	60297753	60297753	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:60297753C>T	ENST00000396057.4	+	2	1070	c.591C>T	c.(589-591)gcC>gcT	p.A197A	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	197					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						TGCCCGCTGCCTACCCGCTCC	0.667000													3	16					0	0	0.004672	0	0
UNC79	57578	broad.mit.edu	37	14	94069648	94069648	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:94069648G>T	ENST00000553484.1	+	26	3792	c.3638G>T	c.(3637-3639)aGa>aTa	p.R1213I	UNC79_ENST00000393151.2_Missense_Mutation_p.R1213I|UNC79_ENST00000256339.4_Missense_Mutation_p.R1036I|UNC79_ENST00000555664.1_Missense_Mutation_p.R1213I			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1213						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AAGATCAAGAGAGCTCGCTTT	0.517000													11	91					9.31168e-06	1.78474e-05	0.001855	1	0
EPG5	57724	broad.mit.edu	37	18	43523190	43523190	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr18:43523190C>A	ENST00000282041.5	-	9	1914	c.1880G>T	c.(1879-1881)gGg>gTg	p.G627V		NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	627					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						GGTTTCTAACCCCACAGCCAG	0.398000													10	60					0.000442599	0.000771753	0.000443	1	0
SOWAHA	134548	broad.mit.edu	37	5	132149857	132149857	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:132149857G>C	ENST00000378693.2	+	1	825	c.544G>C	c.(544-546)Gcc>Ccc	p.A182P		NM_175873.4	NP_787069.3	Q2M3V2	ANR43_HUMAN	sosondowah ankyrin repeat domain family member A	182	Pro-rich.																CGCAGACGCGGCCCCACCGCC	0.756000													4	19					0	0	0.000248	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39355561	39355561	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr22:39355561C>A	ENST00000402255.1	+	3	248	c.44C>A	c.(43-45)cCa>cAa	p.P15Q	APOBEC3A_ENST00000249116.2_Missense_Mutation_p.P15Q					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					TTGATGGATCCACACATATTC	0.542000													12	78					5.50884e-06	1.06858e-05	0.001368	1	0
FLT4	2324	broad.mit.edu	37	5	180056988	180056988	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:180056988C>T	ENST00000261937.6	-	5	709	c.631G>A	c.(631-633)Gga>Aga	p.G211R	FLT4_ENST00000502649.1_Missense_Mutation_p.G211R|FLT4_ENST00000393347.3_Missense_Mutation_p.G211R|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	211	Ig-like C2-type 2.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCCTGGTCTCCCCAGGTGGTC	0.642000													6	53					0	0	0.003080	0	0
MACF1	23499	broad.mit.edu	37	1	39927621	39927621	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:39927621A>G	ENST00000564288.1	+	93	22367	c.21590A>G	c.(21589-21591)tAc>tGc	p.Y7197C	MACF1_ENST00000361689.2_Missense_Mutation_p.Y5138C|MACF1_ENST00000567887.1_Missense_Mutation_p.Y7234C|MACF1_ENST00000289893.4_Missense_Mutation_p.Y5640C|MACF1_ENST00000372915.3_Missense_Mutation_p.Y7096C|MACF1_ENST00000317713.7_Missense_Mutation_p.Y5138C|MACF1_ENST00000539005.1_Missense_Mutation_p.Y5008C|MACF1_ENST00000545844.1_Missense_Mutation_p.Y5138C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	7096	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGGGATGGTTACATTGATTAT	0.418000													35	92					0	0	0.005524	0	0
KIF1B	23095	broad.mit.edu	37	1	10381774	10381774	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:10381774G>T	ENST00000377086.1	+	24	2419	c.2217G>T	c.(2215-2217)tgG>tgT	p.W739C	KIF1B_ENST00000377081.1_Missense_Mutation_p.W739C|KIF1B_ENST00000263934.6_Missense_Mutation_p.W693C			O60333	KIF1B_HUMAN	kinesin family member 1B	739					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CAGTTCCTTGGACACAGCATG	0.413000													5	57					3.59834e-05	6.58332e-05	0.001168	1	0
LRRC4	64101	broad.mit.edu	37	7	127669922	127669922	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:127669922C>T	ENST00000249363.3	-	2	1029	c.772G>A	c.(772-774)Gag>Aag	p.E258K	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	258						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		GCATTCCGCTCAATCAGGCTG	0.542000													4	54					0	0	0.000248	0	0
PABPC4	8761	broad.mit.edu	37	1	40035545	40035545	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:40035545G>A	ENST00000372857.3	-	4	1425	c.633C>T	c.(631-633)ttC>ttT	p.F211F	RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372858.3_Silent_p.F211F|PABPC4_ENST00000372862.3_Silent_p.F211F|PABPC4_ENST00000529216.1_5'UTR|PABPC4_ENST00000372856.3_Silent_p.F211F	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	211	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAAACTGACTGAATAGCTCTT	0.448000													10	66					0	0	0.000978	0	0
KIF15	56992	broad.mit.edu	37	3	44841922	44841922	+	Silent	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:44841922G>C	ENST00000326047.4	+	11	1364	c.1215G>C	c.(1213-1215)ctG>ctC	p.L405L	KIF15_ENST00000425755.1_Silent_p.L40L	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	405					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AAAGCTTCCTGACCAGAGGTA	0.478000													3	45					0	0	0.004672	0	0
USP28	57646	broad.mit.edu	37	11	113675622	113675622	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:113675622C>T	ENST00000003302.4	-	20	2615	c.2547G>A	c.(2545-2547)caG>caA	p.Q849Q	USP28_ENST00000260188.5_Silent_p.Q817Q|USP28_ENST00000544967.1_Silent_p.Q525Q|USP28_ENST00000545540.1_Silent_p.Q692Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	849					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TATCTGCAAACTGTTCCAGAA	0.458000													4	61					0	0	0.000248	0	0
CADPS2	93664	broad.mit.edu	37	7	122221328	122221328	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:122221328C>T	ENST00000334010.7	-	7	1661	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N	CADPS2_ENST00000313070.7_Missense_Mutation_p.D414N|CADPS2_ENST00000449022.2_Missense_Mutation_p.D414N|CADPS2_ENST00000476131.1_5'UTR|CADPS2_ENST00000412584.2_Missense_Mutation_p.D414N	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	414	C2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GTGGTGAAATCTCCTTGAGTC	0.433000													6	99					0	0	0.001984	0	0
CUX2	23316	broad.mit.edu	37	12	111779599	111779599	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:111779599G>T	ENST00000261726.6	+	21	3555	c.3401G>T	c.(3400-3402)cGc>cTc	p.R1134L		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1134						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CTGAAACGTCGCTATGGCCTC	0.652000													16	58					3.32936e-07	6.72837e-07	0.000743	1	0
CLK2	1196	broad.mit.edu	37	1	155237835	155237835	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:155237835C>G	ENST00000368361.4	-	6	952	c.637G>C	c.(637-639)Gag>Cag	p.E213Q	CLK2_ENST00000355560.4_Missense_Mutation_p.E211Q|CLK2_ENST00000536801.1_Missense_Mutation_p.E213Q|CLK2_ENST00000361168.5_Missense_Mutation_p.E212Q|CLK2_ENST00000497188.1_5'UTR			P49760	CLK2_HUMAN	CDC-like kinase 2	213	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTGATTTTCTCTAGCACGTTG	0.493000								Other conserved DNA damage response genes					11	147					0	0	0.000978	0	0
NAV3	89795	broad.mit.edu	37	12	78400786	78400786	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:78400786C>T	ENST00000397909.2	+	8	1641	c.1468C>T	c.(1468-1470)Cag>Tag	p.Q490*	NAV3_ENST00000536525.2_Nonsense_Mutation_p.Q490*|NAV3_ENST00000266692.7_Nonsense_Mutation_p.Q490*|NAV3_ENST00000228327.6_Nonsense_Mutation_p.Q490*			Q8IVL0	NAV3_HUMAN	neuron navigator 3	490						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGAGAAGGATCAGGTGACAGA	0.408000										HNSCC(70;0.22)			6	59					0	0	0.001984	0	0
SNRK	54861	broad.mit.edu	37	3	43381790	43381790	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:43381790G>T	ENST00000296088.7	+	5	1047	c.743G>T	c.(742-744)cGg>cTg	p.R248L	SNRK_ENST00000429705.2_Missense_Mutation_p.R248L|SNRK_ENST00000437827.1_Missense_Mutation_p.R42L|SNRK_ENST00000454177.1_Missense_Mutation_p.R248L	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	248	Protein kinase.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		CTAATCACACGGATGCTACAG	0.403000													24	130					5.35356e-11	1.17535e-10	0.002780	1	0
DNM1P46	196968	broad.mit.edu	37	15	100340011	100340011	+	RNA	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:100340011G>T	ENST00000341853.1	-	0	915					NR_003260.1																						CCACGCGAGTGCAGGTTGGAC	0.612000													5	21					0.000602214	0.00103512	0.000602	1	0
LETMD1	25875	broad.mit.edu	37	12	51451898	51451898	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:51451898C>T	ENST00000418425.2	+	8	1057	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	LETMD1_ENST00000550929.1_Silent_p.S277S|LETMD1_ENST00000547008.1_Silent_p.S209S|LETMD1_ENST00000380123.2_3'UTR|LETMD1_ENST00000552739.1_Silent_p.S216S|LETMD1_ENST00000548516.1_3'UTR|LETMD1_ENST00000262055.4_Silent_p.S333S	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	333	LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						TGCAGATTTCCTGCAGCCTGA	0.403000													10	54					0	0	0.000978	0	0
RIMS2	9699	broad.mit.edu	37	8	105160897	105160897	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:105160897G>T	ENST00000436393.2	+	23	3450	c.3209G>T	c.(3208-3210)aGc>aTc	p.S1070I	RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	499					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGACAAAAAGCACCAGCATC	0.493000										HNSCC(12;0.0054)			6	30					2.0095e-06	3.96158e-06	0.001984	1	0
ZNF407	55628	broad.mit.edu	37	18	72343953	72343953	+	Silent	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr18:72343953G>T	ENST00000299687.5	+	1	978	c.978G>T	c.(976-978)acG>acT	p.T326T	ZNF407_ENST00000309902.6_Silent_p.T326T|ZNF407_ENST00000582337.1_Silent_p.T326T|ZNF407_ENST00000577538.1_Silent_p.T326T	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TGGGAAGCACGTTTAAAGATT	0.358000													20	107					3.10358e-05	5.7655e-05	0.002299	1	0
SLC51B	123264	broad.mit.edu	37	15	65345416	65345416	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:65345416C>A	ENST00000334287.2	+	4	622	c.301C>A	c.(301-303)Cca>Aca	p.P101T		NM_178859.3	NP_849190.2			solute carrier family 51, beta subunit																		CTCAGAAAAGCCAAACTTGGC	0.463000													12	58					0.00010058	0.000181269	0.001368	1	0
MADD	8567	broad.mit.edu	37	11	47303198	47303198	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:47303198C>T	ENST00000342922.4	+	8	1720	c.1363C>T	c.(1363-1365)Ccc>Tcc	p.P455S	MADD_ENST00000402799.1_Missense_Mutation_p.P455S|MADD_ENST00000402192.2_Missense_Mutation_p.P455S|MADD_ENST00000349238.3_Missense_Mutation_p.P455S|MADD_ENST00000395336.3_Missense_Mutation_p.P455S|MADD_ENST00000311027.5_Missense_Mutation_p.P455S|MADD_ENST00000395344.3_Missense_Mutation_p.P455S|MADD_ENST00000489415.1_3'UTR|MADD_ENST00000407859.3_Missense_Mutation_p.P455S|MADD_ENST00000406482.1_Missense_Mutation_p.P455S	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	455					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CCAGGAGATCCCCCTTCTCTT	0.498000													4	48					0	0	0.000248	0	0
TECTB	6975	broad.mit.edu	37	10	114059319	114059319	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr10:114059319C>T	ENST00000369422.3	+	8	904	c.904C>T	c.(904-906)Cgg>Tgg	p.R302W	TECTB_ENST00000494328.1_3'UTR	NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	302						anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		GCTCTCCCTGCGGAGTAAGCG	0.567000													9	54					0	0	0.004482	0	0
OR2M3	127062	broad.mit.edu	37	1	248366443	248366443	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:248366443C>T	ENST00000456743.1	+	1	112	c.74C>T	c.(73-75)aCc>aTc	p.T25I		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCCACCCACACCTTCCTCTTC	0.512000													6	287					0	0	0.003080	0	0
KNTC1	9735	broad.mit.edu	37	12	123087422	123087422	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:123087422G>A	ENST00000333479.7	+	47	5049	c.4872G>A	c.(4870-4872)tcG>tcA	p.S1624S	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000537348.1_Silent_p.S49S|KNTC1_ENST00000436959.3_5'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1624					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding	p.S1624S(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TCTTAATTTCGAAATTAATGA	0.328000													10	82					0	0	0.000978	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994036	45994036	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:45994036C>T	ENST00000400374.3	+	1	431	c.401C>T	c.(400-402)tCa>tTa	p.S134L	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	134	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GGGGATTCTTCATGCTGCCAG	0.647000													11	145					0	0	0.000978	0	0
DSCAM	1826	broad.mit.edu	37	21	41550914	41550914	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:41550914T>C	ENST00000400454.1	-	15	3364	c.2887A>G	c.(2887-2889)Aag>Gag	p.K963E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	963	Fibronectin type-III 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATCCGGTTCTTGGCGTACATG	0.592000													5	51					0	0	0.000602	0	0
GALNT2	2590	broad.mit.edu	37	1	230401018	230401018	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:230401018G>A	ENST00000366672.4	+	14	1417	c.1345G>A	c.(1345-1347)Gcc>Acc	p.A449T	GALNT2_ENST00000541865.1_3'UTR|GALNT2_ENST00000543760.1_Missense_Mutation_p.A411T|RP5-956O18.2_ENST00000440729.1_RNA|GALNT2_ENST00000485438.1_3'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	449	Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				AGCTTTTGGGGCCTTGCAGCA	0.512000													16	183					0	0	0.004007	0	0
MNDA	4332	broad.mit.edu	37	1	158817647	158817647	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:158817647C>T	ENST00000368141.4	+	6	1378	c.1117C>T	c.(1117-1119)Caa>Taa	p.Q373*		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	373	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					CTTCTGCCTTCAACTGAGAAC	0.443000													29	72					0	0	0.001271	0	0
FAM71D	161142	broad.mit.edu	37	14	67665013	67665013	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:67665013C>A	ENST00000556046.1	+	3	359	c.135C>A	c.(133-135)ccC>ccA	p.P45P				Q8N9W8	FA71D_HUMAN	family with sequence similarity 71, member D	45										breast(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(1)	13		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		TATCTCCTCCCATGTTAGAGA	0.398000													5	100					1.23904e-05	2.3196e-05	0.000602	1	0
GPNMB	10457	broad.mit.edu	37	7	23293808	23293808	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:23293808C>T	ENST00000258733.4	+	3	539	c.244C>T	c.(244-246)Ctg>Ttg	p.L82L	GPNMB_ENST00000381990.2_Silent_p.L82L|GPNMB_ENST00000409458.3_Silent_p.L82L|GPNMB_ENST00000539136.1_Intron|GPNMB_ENST00000453162.2_Silent_p.L82L			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	82					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GCAGGCGGTCCTGACCAGTGA	0.453000													4	143					0	0	0.000248	0	0
UGT2B11	10720	broad.mit.edu	37	4	70074116	70074116	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:70074116C>A	ENST00000446444.1	-	3	963	c.955G>T	c.(955-957)Gaa>Taa	p.E319*	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	319					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						TTGGCCCTTTCTGCTGTCATG	0.428000													13	167					7.93312e-07	1.58992e-06	0.002450	1	0
PHACTR4	65979	broad.mit.edu	37	1	28800535	28800535	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:28800535G>A	ENST00000373839.3	+	7	1554	c.1293G>A	c.(1291-1293)atG>atA	p.M431I	PHACTR4_ENST00000373836.3_Missense_Mutation_p.M441I|PHACTR4_ENST00000493669.1_3'UTR	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	431	Pro-rich.						actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CACTTCCCATGACTCCTATTC	0.537000													13	62					0	0	0.001855	0	0
IQCC	55721	broad.mit.edu	37	1	32672206	32672206	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:32672206G>C	ENST00000537469.1	+	3	570	c.523G>C	c.(523-525)Gag>Cag	p.E175Q	RP4-622L5.7_ENST00000421616.1_RNA|IQCC_ENST00000291358.6_Missense_Mutation_p.E95Q	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	95										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTCTGAGGGAGAGGCCACCTG	0.537000													8	78					0	0	0.003080	0	0
TFDP3	51270	broad.mit.edu	37	X	132351910	132351910	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:132351910C>A	ENST00000310125.4	-	1	466	c.378G>T	c.(376-378)ggG>ggT	p.G126G		NM_016521.2	NP_057605.3	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	126						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(1)|lung(8)|ovary(1)|prostate(2)	19	Acute lymphoblastic leukemia(192;0.000127)					AGGAAGTGGTCCCTTTCCTCT	0.577000													14	30					2.32078e-09	5.00419e-09	0.003163	1	0
ATP1A2	477	broad.mit.edu	37	1	160104960	160104960	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:160104960G>T	ENST00000361216.3	+	15	2079	c.1990G>T	c.(1990-1992)Ggc>Tgc	p.G664C	ATP1A2_ENST00000392233.3_Missense_Mutation_p.G664C|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	664					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.G664S(2)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGTGGTGCACGGCTCTGACCT	0.597000													12	44					2.27111e-07	4.62847e-07	0.001368	1	0
XXYLT1	152002	broad.mit.edu	37	3	194790681	194790681	+	Silent	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:194790681C>A	ENST00000310380.6	-	4	1053	c.945G>T	c.(943-945)gtG>gtT	p.V315V	XXYLT1_ENST00000429994.1_Silent_p.V169V|XXYLT1_ENST00000356740.5_Silent_p.V109V|XXYLT1_ENST00000355729.4_Silent_p.V112V|XXYLT1_ENST00000460582.1_5'UTR|XXYLT1_ENST00000437101.1_Silent_p.V112V	NM_152531.4	NP_689744.3	Q8NBI6	CC021_HUMAN	xyloside xylosyltransferase 1	315						integral to membrane	transferase activity, transferring glycosyl groups										CCAGCTGCTGCACCTGCGCCG	0.662000													9	34					1.12685e-05	2.12605e-05	0.004482	1	0
TLR4	7099	broad.mit.edu	37	9	120470885	120470885	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:120470885C>G	ENST00000355622.6	+	2	239	c.138C>G	c.(136-138)taC>taG	p.Y46*	TLR4_ENST00000394487.4_Nonsense_Mutation_p.Y6*|TLR4_ENST00000472304.1_Intron	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	46					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGAATTTCTACAAAATCCCCG	0.448000													7	94					0	0	0.001984	0	0
RP1	6101	broad.mit.edu	37	8	55537716	55537716	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:55537716G>T	ENST00000220676.1	+	4	1422	c.1274G>T	c.(1273-1275)tGg>tTg	p.W425L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	425					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCTGCTAGTTGGGAGAATGCT	0.458000													8	73					2.74318e-10	5.99528e-10	0.000443	1	0
PDE10A	10846	broad.mit.edu	37	6	165746548	165746548	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:165746548G>A	ENST00000366882.1	-	23	2460	c.2306C>T	c.(2305-2307)tCc>tTc	p.S769F	PDE10A_ENST00000539869.2_Missense_Mutation_p.S779F|PDE10A_ENST00000354448.4_Missense_Mutation_p.S769F			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	769					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CTGAGCCACGGATGGGGATGA	0.502000													13	107					0	0	0.001855	0	0
BTBD7	55727	broad.mit.edu	37	14	93760232	93760232	+	Silent	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr14:93760232C>G	ENST00000334746.5	-	3	1441	c.1134G>C	c.(1132-1134)ctG>ctC	p.L378L	BTBD7_ENST00000554565.1_Intron|BTBD7_ENST00000298896.3_Silent_p.L378L|BTBD7_ENST00000555525.1_Silent_p.L378L|BTBD7_ENST00000393170.2_Silent_p.L47L	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	378										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ATTCCAAGAACAGTGCTATGT	0.428000													3	38					0	0	0.004672	0	0
TRPC5	7224	broad.mit.edu	37	X	111195531	111195531	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:111195531C>A	ENST00000262839.2	-	2	1036	c.118G>T	c.(118-120)Gtg>Ttg	p.V40L		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	40					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CCCTTCTCCACAGCATTGAGG	0.537000													8	26					0.000274275	0.000481727	0.004482	1	0
DBX2	440097	broad.mit.edu	37	12	45410212	45410212	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:45410212C>A	ENST00000332700.6	-	4	1048	c.877G>T	c.(877-879)Gag>Tag	p.E293*		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	293						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GGAGAATTCTCCCTCCATCTT	0.498000													10	81					4.68919e-08	9.76241e-08	0.000673	1	0
VWF	7450	broad.mit.edu	37	12	6127849	6127849	+	Missense_Mutation	SNP	C	C	A	rs61750113		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:6127849C>A	ENST00000261405.5	-	28	4989	c.4735G>T	c.(4735-4737)Ggg>Tgg	p.G1579W		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1579	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	agggccagcccagtgttggtc	0.632000													11	45					4.68919e-08	9.76241e-08	0.000673	1	0
CASC1	55259	broad.mit.edu	37	12	25299993	25299993	+	Missense_Mutation	SNP	C	C	A	rs150934185		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:25299993C>A	ENST00000354189.5	-	8	840	c.805G>T	c.(805-807)Gtc>Ttc	p.V269F	CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000545133.1_Missense_Mutation_p.V146F|CASC1_ENST00000395987.3_Missense_Mutation_p.V211F|CASC1_ENST00000395990.2_Missense_Mutation_p.V165F|CASC1_ENST00000320267.9_Missense_Mutation_p.V205F|CASC1_ENST00000537577.1_Missense_Mutation_p.V93F	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	205										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TCTTTAATGACTTTTTCCATA	0.388000													10	86					1.08611e-07	2.24184e-07	0.000978	1	0
NUTM1	256646	broad.mit.edu	37	15	34648999	34648999	+	Silent	SNP	C	C	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:34648999C>T	ENST00000537011.1	+	8	3172	c.2790C>T	c.(2788-2790)aaC>aaT	p.N930N	NUTM1_ENST00000333756.4_Silent_p.N902N|NUTM1_ENST00000438749.3_Silent_p.N920N					NUT midline carcinoma, family member 1																		AACCTGTCAACATACTAGATG	0.517000													5	50					0	0	0.001168	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041116	64041116	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr12:64041116G>T	ENST00000324472.4	-	5	801	c.618C>A	c.(616-618)ttC>ttA	p.F206L	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	206					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTATTCCCATGAATGTGCAAT	0.308000													18	75					0.00152264	0.0025536	0.001523	1	0
GJB4	127534	broad.mit.edu	37	1	35227474	35227474	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:35227474T>C	ENST00000339480.1	+	2	989	c.619T>C	c.(619-621)Tac>Cac	p.Y207H	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	207					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TGAAGTCTTCTACCTGGTGGG	0.592000													6	68					0	0	0.003080	0	0
ACSM2A	123876	broad.mit.edu	37	16	20497956	20497956	+	Nonsense_Mutation	SNP	C	C	T	rs143956389		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:20497956C>T	ENST00000573854.1	+	14	1804	c.1690C>T	c.(1690-1692)Cga>Tga	p.R564*	ACSM2A_ENST00000575690.1_Nonsense_Mutation_p.R564*|ACSM2A_ENST00000396104.2_Nonsense_Mutation_p.R564*|ACSM2A_ENST00000219054.6_Nonsense_Mutation_p.R564*|ACSM2A_ENST00000417235.2_Nonsense_Mutation_p.R485*|ACSM2A_ENST00000536134.1_Nonsense_Mutation_p.R336*	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	564					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGCCAAGCTTCGAGACAAGGA	0.458000													13	141					0	0	0.002450	0	0
MAGEA4	4103	broad.mit.edu	37	X	151093075	151093075	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:151093075G>A	ENST00000360243.2	+	3	1206	c.939G>A	c.(937-939)gaG>gaA	p.E313E	MAGEA4_ENST00000370337.4_Silent_p.E313E|MAGEA4_ENST00000276344.2_Silent_p.E313E|MAGEA4_ENST00000393920.1_Silent_p.E313E|MAGEA4_ENST00000393921.1_Silent_p.E313E|MAGEA4_ENST00000370340.3_Silent_p.E313E|MAGEA4_ENST00000370335.1_Silent_p.E313E	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	313							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGTTAGAGGAGGAAGAGGGAG	0.572000													14	36					0	0	0.002450	0	0
HEATR1	55127	broad.mit.edu	37	1	236740143	236740143	+	Silent	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:236740143C>G	ENST00000366582.3	-	21	2976	c.2862G>C	c.(2860-2862)ctG>ctC	p.L954L	HEATR1_ENST00000366581.2_Silent_p.L954L	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	954					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GATCTATTATCAGATAAAACG	0.443000													10	58					0	0	0.000443	0	0
ABCA9	10350	broad.mit.edu	37	17	67014646	67014646	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:67014646T>C	ENST00000340001.4	-	20	2886	c.2675A>G	c.(2674-2676)tAc>tGc	p.Y892C	ABCA9_ENST00000370732.2_Missense_Mutation_p.Y892C|ABCA9_ENST00000453985.2_Missense_Mutation_p.Y892C	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	892					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTCCCACGGGTAACTTTTCTG	0.388000													8	281					0	0	0.004482	0	0
GJC2	57165	broad.mit.edu	37	1	228345700	228345700	+	Missense_Mutation	SNP	G	G	A	rs149908950		TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:228345700G>A	ENST00000366714.2	+	2	416	c.241G>A	c.(241-243)Gtc>Atc	p.V81I		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	81					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				GCGCTTCTGGGTCTTCCAGAT	0.667000													4	27					0	0	0.000602	0	0
RPL7L1	285855	broad.mit.edu	37	6	42851305	42851305	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:42851305G>T	ENST00000493763.1	+	3	540	c.237G>T	c.(235-237)ttG>ttT	p.L79F	RPL7L1_ENST00000424341.2_Missense_Mutation_p.L79F|RPL7L1_ENST00000602561.1_Missense_Mutation_p.L79F|RPL7L1_ENST00000304734.5_Missense_Mutation_p.L79F|RPL7L1_ENST00000397415.3_3'UTR	NM_198486.2	NP_940888.2	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	79					translation	large ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(1)|lung(3)	6	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			CTCATGCCTTGGAATTGCCAG	0.473000													7	47					0.00198382	0.00330408	0.001984	1	0
SLCO4A1	28231	broad.mit.edu	37	20	61299190	61299190	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr20:61299190C>A	ENST00000217159.1	+	8	1771	c.1566C>A	c.(1564-1566)gaC>gaA	p.D522E	SLCO4A1_ENST00000470412.1_3'UTR|SLCO4A1_ENST00000370507.1_Missense_Mutation_p.D522E	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	522	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GCGGCTCGGACGGCCTCATGT	0.652000													11	59					2.27111e-07	4.62847e-07	0.001368	1	0
EPHB3	2049	broad.mit.edu	37	3	184294827	184294827	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr3:184294827G>T	ENST00000330394.2	+	5	1662	c.1210G>T	c.(1210-1212)Ggc>Tgc	p.G404C	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	404	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TCGGCAGCTGGGCCTGACGGA	0.627000													27	71					9.86323e-18	2.21579e-17	0.003954	1	0
PRKDC	5591	broad.mit.edu	37	8	48746951	48746951	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr8:48746951C>G	ENST00000314191.2	-	60	8011	c.7955G>C	c.(7954-7956)aGa>aCa	p.R2652T	PRKDC_ENST00000338368.3_Missense_Mutation_p.R2652T|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2653	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AAATGAGCTTCTTCCATCTGT	0.582000								Non-homologous end-joining					5	82					0	0	0.000602	0	0
DNMT3A	1788	broad.mit.edu	37	2	25462066	25462066	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr2:25462066C>G	ENST00000264709.3	-	20	2678	c.2341G>C	c.(2341-2343)Gat>Cat	p.D781H	DNMT3A_ENST00000402667.1_Missense_Mutation_p.D558H|DNMT3A_ENST00000380746.4_Missense_Mutation_p.D592H|DNMT3A_ENST00000474887.1_5'UTR|DNMT3A_ENST00000321117.5_Missense_Mutation_p.D781H	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	781					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTGGCATCAATCATCACA	0.557000			"""Mis, F, N, S"""		AML								3	25					0	0	0.000248	0	0
BRWD3	254065	broad.mit.edu	37	X	79978183	79978183	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chrX:79978183G>C	ENST00000373275.4	-	17	1970	c.1754C>G	c.(1753-1755)cCt>cGt	p.P585R		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	585										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AAATGGAGGAGGCATGAGGTG	0.433000													12	28					0	0	0.000978	0	0
MAML1	9794	broad.mit.edu	37	5	179201778	179201778	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:179201778C>G	ENST00000292599.3	+	5	3214	c.2951C>G	c.(2950-2952)tCt>tGt	p.S984C	MAML1_ENST00000503050.1_Intron	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	984					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTGGGCTCTCTAGTGTGGCT	0.612000													4	87					0	0	0.000602	0	0
ANGEL2	90806	broad.mit.edu	37	1	213181770	213181770	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr1:213181770C>G	ENST00000366962.3	-	3	578	c.424G>C	c.(424-426)Gat>Cat	p.D142H	ANGEL2_ENST00000535388.1_5'UTR|ANGEL2_ENST00000360506.2_5'UTR|ANGEL2_ENST00000540642.1_Missense_Mutation_p.D16H|ANGEL2_ENST00000544555.1_5'UTR	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	142										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TTTTCTTTATCATGGCTACAT	0.333000													4	62					0	0	0.000248	0	0
IGSF6	10261	broad.mit.edu	37	16	21658803	21658803	+	Silent	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:21658803G>T	ENST00000268389.4	-	2	139	c.78C>A	c.(76-78)ggC>ggA	p.G26G	METTL9_ENST00000358154.3_Intron|METTL9_ENST00000396014.4_Intron	NM_005849.3	NP_005840.2	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6	26					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(48;0.066)		GAGTACAGGCGCCCACAGCAC	0.512000													11	46					3.86212e-05	7.0128e-05	0.000673	1	0
SEMA5A	9037	broad.mit.edu	37	5	9237964	9237964	+	Silent	SNP	G	G	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr5:9237964G>T	ENST00000382496.5	-	6	974	c.309C>A	c.(307-309)gcC>gcA	p.A103A		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	103	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TGCTGTAACAGGCCTTTTTGG	0.378000													6	54					1.26484e-09	2.73955e-09	0.003080	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18194851	18194851	+	Missense_Mutation	SNP	C	C	A	rs140036768	byFrequency	TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr11:18194851C>A	ENST00000314254.3	+	1	468	c.48C>A	c.(46-48)aaC>aaA	p.N16K	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	16						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						CACCAATCAACGGACGTGAGG	0.532000													9	137					0.00448238	0.00743983	0.004482	1	0
ACPT	93650	broad.mit.edu	37	19	51298098	51298098	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr19:51298098C>G	ENST00000270593.1	+	10	1042	c.1042C>G	c.(1042-1044)Ctc>Gtc	p.L348V	ACPT_ENST00000270594.3_Missense_Mutation_p.L255V	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	348						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCCCCTGCCTCTCAGCCTCCC	0.677000													20	159					0	0	0.002780	0	0
SNHG14	104472715	broad.mit.edu	37	15	25419980	25419980	+	RNA	SNP	T	T	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:25419980T>C	ENST00000549301.1	+	0	715				SNHG14_ENST00000441592.2_RNA																							ttggggtccctgacttccctc	0.507000													3	85					0	0	0.004672	0	0
FRYL	285527	broad.mit.edu	37	4	48501637	48501637	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr4:48501637T>G	ENST00000358350.4	-	64	9448	c.8844A>C	c.(8842-8844)ttA>ttC	p.L2948F	FRYL_ENST00000503238.1_Missense_Mutation_p.L2948F|FRYL_ENST00000264319.7_Missense_Mutation_p.L338F|FRYL_ENST00000507873.2_Missense_Mutation_p.L338F|FRYL_ENST00000537810.1_Missense_Mutation_p.L2948F	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	2948					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AATATATATGTAACAGTGTCT	0.433000													4	75					0	0	0.000248	0	0
CLEC16A	23274	broad.mit.edu	37	16	11214550	11214550	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr16:11214550A>C	ENST00000409790.1	+	20	2425	c.2195A>C	c.(2194-2196)tAc>tCc	p.Y732S	CLEC16A_ENST00000465491.1_3'UTR|CLEC16A_ENST00000409552.3_Missense_Mutation_p.Y714S	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	732								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GTGGATATTTACCAGATGAGT	0.532000													6	9					0	0	0.001168	0	0
FAM214B	80256	broad.mit.edu	37	9	35107819	35107819	+	Silent	SNP	G	G	A			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr9:35107819G>A	ENST00000378561.1	-	2	3508	c.453C>T	c.(451-453)tcC>tcT	p.S151S	FAM214B_ENST00000488109.2_Silent_p.S151S|FAM214B_ENST00000322813.5_Silent_p.S151S|FAM214B_ENST00000605244.1_Silent_p.S151S|FAM214B_ENST00000603301.1_Silent_p.S151S|FAM214B_ENST00000378554.2_Silent_p.S151S|FAM214B_ENST00000378566.1_Intron|FAM214B_ENST00000378557.1_Silent_p.S151S			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	151						nucleus											AAGTATTGCAGGAAGCATTTG	0.632000													6	65					0	0	0.001984	0	0
SLC18B1	116843	broad.mit.edu	37	6	133093332	133093332	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr6:133093332C>G	ENST00000275227.4	-	11	1195	c.1099G>C	c.(1099-1101)Gaa>Caa	p.E367Q		NM_052831.2	NP_439896.1	Q6NT16	CF192_HUMAN	solute carrier family 18, subfamily B, member 1	367					transmembrane transport	integral to membrane											AATCCCTCTTCAAACCCATTT	0.303000													3	39					0	0	0.004672	0	0
ZAN	7455	broad.mit.edu	37	7	100385562	100385596	+	RNA	DEL	GCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	GCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	-	rs68029369	by1000genomes	TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr7:100385562_100385596delGCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	ENST00000542585.1	+	0	7176_7210				ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACATTTGACGGCTTCAGCTACCGCTTGCAAGGCCGCATGACCTATGTTCTGATCA	0.583													7	31	---	---	---	---					
PIGB	9488	broad.mit.edu	37	15	55631502	55631503	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr15:55631502_55631503insT	ENST00000164305.5	+	7	1123_1124	c.832_833insT	c.(832-834)tttfs	p.F278fs	PIGB_ENST00000539642.1_Frame_Shift_Ins_p.F83fs	NM_004855.4	NP_004846.4	Q92521	PIGB_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class B	278					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	11				all cancers(107;0.0255)		GATTGATCGTATTTTTTTTGGC	0.282													3	6	---	---	---	---					
GAA	2548	broad.mit.edu	37	17	78085790	78085790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr17:78085790delG	ENST00000302262.3	+	12	1864	c.1645delG	c.(1645-1647)ggfs	p.G550fs	GAA_ENST00000390015.3_Frame_Shift_Del_p.G550fs	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	550					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	AGGGGTGGTTGGGGGGACCCT	0.672													10	48	---	---	---	---					
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-6987-01A-11D-1945-08	TCGA-55-6987-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	375c7a6d-607f-40f4-8e3a-2352150ba073	2c93f910-2aee-45ab-9b50-66d0f1797df3	g.chr21:10944697delA	ENST00000298232.7	-	10	850	c.483delT	c.(481-483)ttfs	p.F161fs	TPTE_ENST00000342420.5_Frame_Shift_Del_p.F141fs|TPTE_ENST00000361285.4_Frame_Shift_Del_p.F179fs|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299													7	221	---	---	---	---					
