Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NMUR2	56923	broad.mit.edu	37	5	151784186	151784186	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:151784186G>T	ENST00000255262.3	-	1	654	c.489C>A	c.(487-489)gcC>gcA	p.A163A	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	163					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GGATCCTGAGGGCCCGGCGCC	0.637000													19	35					2.94398e-08	3.38937e-08	1	1	0
TRBV6-5	28602	broad.mit.edu	37	7	142180795	142180795	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:142180795C>A	ENST00000390368.2	-	0	129																											TGAGTGACACCAGCATTCACT	0.537000													6	135					0.00448238	0.00470495	1	1	0
GPR142	350383	broad.mit.edu	37	17	72368126	72368126	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:72368126C>A	ENST00000335666.4	+	4	824	c.776C>A	c.(775-777)gCc>gAc	p.A259D		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	259						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CGCTACACTGCCCTGTGCCAC	0.682000													32	97					2.19489e-29	3.28801e-29	1	1	0
CD82	3732	broad.mit.edu	37	11	44626733	44626733	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:44626733G>T	ENST00000227155.4	+	5	509		c.e5+1		CD82_ENST00000530931.1_Splice_Site|RP11-58K22.5_ENST00000533814.1_RNA|CD82_ENST00000342935.3_Splice_Site	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule							integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						GCTGGGGCTGGTGAGTACGGA	0.657000													4	60					1.23904e-05	1.36654e-05	1	1	0
RPTOR	57521	broad.mit.edu	37	17	78796041	78796041	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:78796041G>A	ENST00000306801.3	+	8	1293	c.931G>A	c.(931-933)Gaa>Aaa	p.E311K	RPTOR_ENST00000570891.1_Missense_Mutation_p.E311K|RPTOR_ENST00000544334.2_Missense_Mutation_p.E311K|RPTOR_ENST00000537330.1_Missense_Mutation_p.E126K|RPTOR_ENST00000575542.1_3'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	311					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						GCCCCTGGGTGAACTGAACTG	0.627000													70	468					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125988590	125988590	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:125988590G>T	ENST00000319286.5	+	3	234	c.79_splice	c.e3-1	p.G27_splice		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			ATTCTTGCAGGAGATACAAGT	0.333000										HNSCC(60;0.17)			6	57					0.248553	0.249207	1	1	0
SPEG	10290	broad.mit.edu	37	2	220326736	220326736	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:220326736G>A	ENST00000312358.7	+	7	2705	c.2573G>A	c.(2572-2574)cGc>cAc	p.R858H	SPEG_ENST00000396686.1_Missense_Mutation_p.R9H|SPEG_ENST00000396695.2_Missense_Mutation_p.R66H|SPEG_ENST00000396688.1_Missense_Mutation_p.R9H|SPEG_ENST00000396689.2_Missense_Mutation_p.R9H|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396698.1_Missense_Mutation_p.R754H	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	858					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCCAGAACCGCCGTTCTTCT	0.657000													26	100					0	0	1	0	0
MCMBP	79892	broad.mit.edu	37	10	121600468	121600468	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:121600468T>C	ENST00000360003.3	-	11	1304	c.1135A>G	c.(1135-1137)Aca>Gca	p.T379A	MCMBP_ENST00000369077.3_Missense_Mutation_p.T377A|MCMBP_ENST00000466047.1_5'UTR	NM_001256378.1|NM_001256379.1|NM_024834.3	NP_001243307.1|NP_001243308.1|NP_079110.1	Q9BTE3	MCMBP_HUMAN	minichromosome maintenance complex binding protein	379					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding			breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(2)|skin(2)	21						TCTCTTCTTGTATATCTAGAA	0.328000													6	34					0	0	1	0	0
FAM209B	388799	broad.mit.edu	37	20	55111383	55111383	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:55111383T>A	ENST00000371325.1	+	2	501	c.405T>A	c.(403-405)ggT>ggA	p.G135G		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	135						integral to membrane											ATCTTAAAGGTGCCATGGCAA	0.413000													11	104					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132082031	132082031	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:132082031C>A	ENST00000374786.1	+	3	995	c.516C>A	c.(514-516)atC>atA	p.I172I	NTM_ENST00000425719.2_Silent_p.I172I|NTM_ENST00000427481.2_Silent_p.I163I|NTM_ENST00000374784.1_Silent_p.I172I|NTM_ENST00000374791.3_Silent_p.I172I|NTM_ENST00000539799.1_Silent_p.I172I|NTM_ENST00000474900.1_3'UTR	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	172	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GGAGACACATCTCTCCCAAAG	0.438000													26	88					1.62565e-12	2.03139e-12	1	1	0
NEURL4	84461	broad.mit.edu	37	17	7228151	7228151	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:7228151G>T	ENST00000399464.2	-	9	1795	c.1780C>A	c.(1780-1782)Cag>Aag	p.Q594K	NEURL4_ENST00000315614.7_Missense_Mutation_p.Q594K|NEURL4_ENST00000570460.1_Missense_Mutation_p.Q572K	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAGGGCAACTGGAGGTAGGCA	0.587000											OREG0024134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	195					1.55811e-20	2.19986e-20	1	1	0
SDK1	221935	broad.mit.edu	37	7	4116702	4116702	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:4116702A>T	ENST00000404826.2	+	21	3222	c.3083A>T	c.(3082-3084)cAc>cTc	p.H1028L	SDK1_ENST00000389531.3_Missense_Mutation_p.H1028L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1028	Fibronectin type-III 4.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCACGACGCACGAGTACAAG	0.562000													9	106					0	0	1	0	0
ZNF136	7695	broad.mit.edu	37	19	12298301	12298301	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:12298301G>T	ENST00000343979.4	+	4	1248	c.1108G>T	c.(1108-1110)Ggg>Tgg	p.G370W	ZNF136_ENST00000398616.2_Missense_Mutation_p.G304W	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	370					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						TAAGGAATGTGGGGAAGCATT	0.388000													13	30					2.31682e-05	2.54784e-05	1	1	0
SCEL	8796	broad.mit.edu	37	13	78130833	78130833	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:78130833G>A	ENST00000535157.1	+	3	316	c.146G>A	c.(145-147)cGc>cAc	p.R49H	SCEL_ENST00000349847.3_Missense_Mutation_p.R49H|SCEL_ENST00000377246.3_Missense_Mutation_p.R49H	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	49					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ATAAAGAAACGCCCTGAAGAA	0.463000													12	83					0	0	1	0	0
IMPAD1	54928	broad.mit.edu	37	8	57890671	57890671	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:57890671C>A	ENST00000262644.4	-	3	842	c.584G>T	c.(583-585)tGt>tTt	p.C195F		NM_017813.4	NP_060283.3	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	195						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				TACAGCCACACACACCATAGT	0.328000													20	189					1.1423e-28	1.7045e-28	1	1	0
TBX3	6926	broad.mit.edu	37	12	115120784	115120784	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:115120784G>C	ENST00000349155.2	-	1	1185	c.222C>G	c.(220-222)acC>acG	p.T74T	TBX3_ENST00000257566.3_Silent_p.T74T	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	74					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		ACGGGATGCCGGTCTCGGCCG	0.697000													7	24					0	0	1	0	0
COCH	1690	broad.mit.edu	37	14	31346828	31346828	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:31346828A>G	ENST00000396618.3	+	4	189	c.133A>G	c.(133-135)Aaa>Gaa	p.K45E	RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000216361.4_Missense_Mutation_p.K45E|COCH_ENST00000475087.1_Missense_Mutation_p.K45E|COCH_ENST00000460581.2_5'UTR	NM_004086.2	NP_004077.1	O43405	COCH_HUMAN	cochlin	45	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CAGGAAAGAGAAAGCAGATGT	0.463000													9	46					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947932	237947932	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:237947932G>T	ENST00000366574.2	+	90	13237	c.12920G>T	c.(12919-12921)cGc>cTc	p.R4307L	RYR2_ENST00000542537.1_Missense_Mutation_p.R4291L|RYR2_ENST00000360064.6_Missense_Mutation_p.R4313L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4307					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R4305L(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCTTTTTCCGCATCATTTGC	0.502000													35	54					3.66082e-28	5.45182e-28	1	1	0
BCKDHB	594	broad.mit.edu	37	6	80881045	80881045	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:80881045C>T	ENST00000320393.6	+	6	727	c.680C>T	c.(679-681)tCa>tTa	p.S227L	BCKDHB_ENST00000356489.5_Missense_Mutation_p.S227L|BCKDHB_ENST00000545529.1_3'UTR	NM_183050.2	NP_898871.1	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	227					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CTTCTTTTGTCATGCATAGAG	0.308000													5	21					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76069856	76069856	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:76069856C>G	ENST00000416245.1	+	6	1553	c.460C>G	c.(460-462)Cca>Gca	p.P154A	ZP3_ENST00000394857.3_Missense_Mutation_p.P330A|ZP3_ENST00000336517.4_Missense_Mutation_p.P279A|ZP3_ENST00000467555.1_3'UTR			P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	330	ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						CTGTGGCACTCCAAGCCATTC	0.527000													77	283					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73521482	73521482	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:73521482G>A	ENST00000418310.1	+	8	1216	c.1114G>A	c.(1114-1116)Ggg>Agg	p.G372R	LIMK1_ENST00000336180.2_Missense_Mutation_p.G342R|LIMK1_ENST00000538333.3_Missense_Mutation_p.G308R			P53667	LIMK1_HUMAN	LIM domain kinase 1	342	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CCTCATCCACGGGGAGGTGCT	0.677000													3	129					0	0	1	0	0
RSU1	6251	broad.mit.edu	37	10	16859039	16859039	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:16859039C>T	ENST00000377921.3	-	1	343	c.42G>A	c.(40-42)gaG>gaA	p.E14E	RSU1_ENST00000345264.5_Silent_p.E14E|RSU1_ENST00000602389.1_Intron|RSU1_ENST00000464074.2_Intron			Q15404	RSU1_HUMAN	Ras suppressor protein 1	14					cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(1;7.54e-08)		GCTGGTTCTTCTCCCGGCTCT	0.577000													25	181					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72738406	72738406	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:72738406G>T	ENST00000333149.2	-	2	580	c.380C>A	c.(379-381)aCc>aAc	p.T127N	TRIM50_ENST00000453152.1_Missense_Mutation_p.T127N|TRIM50_ENST00000493498.1_5'UTR	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	127						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						GCTGTAGACGGTGGAGACGGG	0.657000											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	127					5.22007e-41	8.0252e-41	1	1	0
C11orf68	83638	broad.mit.edu	37	11	65684941	65684941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:65684941C>A	ENST00000438576.2	-	2	956	c.871G>T	c.(871-873)Gaa>Taa	p.E291*	C11orf68_ENST00000449692.3_Nonsense_Mutation_p.E290*|C11orf68_ENST00000530188.1_Nonsense_Mutation_p.E249*			Q9H3H3	CK068_HUMAN	chromosome 11 open reading frame 68	249										large_intestine(1)|lung(3)	4				READ - Rectum adenocarcinoma(159;0.166)		TAGGTCAGTTCCACGTTGTTG	0.617000													35	140					2.24893e-16	2.99726e-16	1	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64532515	64532515	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:64532515G>T	ENST00000498707.1	-	32	5325	c.4983C>A	c.(4981-4983)ggC>ggA	p.G1661G	ADAMTS9_ENST00000295903.4_Silent_p.G1633G	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1661	TSP type-1 14.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGGGCTGCGTGCCTGGGCAGT	0.547000													21	81					5.26018e-13	6.64949e-13	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103345257	103345257	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:103345257T>A	ENST00000358392.2	-	66	5609	c.5292A>T	c.(5290-5292)acA>acT	p.T1764T	COL11A1_ENST00000353414.4_Silent_p.T1713T|COL11A1_ENST00000370096.3_Silent_p.T1752T|COL11A1_ENST00000512756.1_Silent_p.T1636T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1752	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CATCATACAGTGTTTTGATAA	0.433000													9	86					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202043	248202043	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:248202043C>A	ENST00000366479.2	+	1	570	c.474C>A	c.(472-474)caC>caA	p.H158Q	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTTGTGCTCACACAGTATATG	0.423000													40	261					9.62906e-15	1.24833e-14	1	1	0
MYT1L	23040	broad.mit.edu	37	2	1842939	1842939	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:1842939C>A	ENST00000399161.2	-	21	3809	c.3062G>T	c.(3061-3063)aGc>aTc	p.S1021I	MYT1L_ENST00000428368.2_Missense_Mutation_p.S1019I|MYT1L_ENST00000407844.1_Missense_Mutation_p.S17I|MYT1L_ENST00000471668.1_5'UTR	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1021					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGTGAGGAAGCTGCCGCTGAC	0.667000													5	24					0.014758	0.0151563	1	1	0
PIRT	644139	broad.mit.edu	37	17	10728817	10728817	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:10728817C>T	ENST00000580256.1	-	2	784	c.146G>A	c.(145-147)tGg>tAg	p.W49*		NM_001101387.1	NP_001094857.1	P0C851	PIRT_HUMAN	phosphoinositide-interacting regulator of transient receptor potential channels	49						integral to membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)	8						GTAGATTTCCCAGTTACTCCT	0.592000													10	19					0	0	1	0	0
UCK2	7371	broad.mit.edu	37	1	165865517	165865517	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:165865517C>T	ENST00000367879.4	+	4	750	c.447C>T	c.(445-447)ttC>ttT	p.F149F	RP11-525G13.2_ENST00000455257.1_RNA|UCK2_ENST00000372212.4_Intron	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	149					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GAGACCTGTTCCAGATGAAGC	0.557000													43	388					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33572544	33572544	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:33572544A>T	ENST00000404816.2	+	26	4320	c.3967A>T	c.(3967-3969)Atg>Ttg	p.M1323L	LTBP1_ENST00000418533.2_Missense_Mutation_p.M955L|LTBP1_ENST00000354476.3_Missense_Mutation_p.M1324L|LTBP1_ENST00000404525.1_Missense_Mutation_p.M944L|LTBP1_ENST00000390003.4_Missense_Mutation_p.M998L|LTBP1_ENST00000402934.1_Missense_Mutation_p.M944L|LTBP1_ENST00000407925.1_Missense_Mutation_p.M997L|LTBP1_ENST00000272273.5_Missense_Mutation_p.M221L			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1323	EGF-like 14; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTACAGCCCCATGACTGGGCA	0.557000													25	164					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8615069	8615069	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:8615069G>T	ENST00000338257.8	-	10	1343	c.1076C>A	c.(1075-1077)gCc>gAc	p.A359D		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	359	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GAAGAGGCGGGCATAGAGCCC	0.627000													29	33					3.90053e-15	5.08271e-15	1	1	0
DPAGT1	1798	broad.mit.edu	37	11	118971380	118971380	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:118971380G>A	ENST00000409993.2	-	5	2007	c.456C>T	c.(454-456)ccC>ccT	p.P152P	DPAGT1_ENST00000445653.1_5'UTR|DPAGT1_ENST00000354202.4_Silent_p.P152P|DPAGT1_ENST00000432443.2_Silent_p.P45P			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	152					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GGAAGGGCTTGGGCACCACAA	0.567000											OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	62					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24996713	24996713	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:24996713C>T	ENST00000323848.9	+	15	2622	c.2307C>T	c.(2305-2307)tcC>tcT	p.S769S	SRRM1_ENST00000447431.2_Silent_p.S781S|SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000374389.4_Silent_p.S778S	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	769	Pro-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CACCTCCATCCCCCGTCCAGT	0.577000													28	145					0	0	1	0	0
IGKV3D-15	28875	broad.mit.edu	37	2	90154133	90154133	+	RNA	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:90154133A>T	ENST00000417279.2	+	0	269																											TGCATCCACCAGGGCCACTGG	0.562000													17	90					0	0	1	0	0
FAM101A	144347	broad.mit.edu	37	12	124798748	124798748	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:124798748G>A	ENST00000389727.3	+	3	328	c.328G>A	c.(328-330)Gag>Aag	p.E110K	FAM101A_ENST00000338359.4_Missense_Mutation_p.E29K|FAM101A_ENST00000324038.3_Missense_Mutation_p.E29K|FAM101A_ENST00000546355.1_Missense_Mutation_p.E29K			Q6ZTI6	F101A_HUMAN	family with sequence similarity 101, member A	110										endometrium(1)|kidney(1)|lung(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CTGCAACTCTGAGGTCAAGTA	0.617000													13	51					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448393	89448393	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:89448393C>A	ENST00000399794.2	-	3	1832	c.1117G>T	c.(1117-1119)Ggt>Tgt	p.G373C	CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.G373C	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	373							nucleotide binding|RNA binding										GGGCCAGCACCTCTTGGTGCT	0.512000													27	149					1.04352e-10	1.26653e-10	1	1	0
TRIM6	117854	broad.mit.edu	37	11	5632082	5632082	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:5632082T>C	ENST00000380097.3	+	8	1303	c.1061T>C	c.(1060-1062)gTg>gCg	p.V354A	TRIM6_ENST00000445329.1_Missense_Mutation_p.V151A|TRIM6_ENST00000278302.5_Missense_Mutation_p.V326A|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000507320.1_Missense_Mutation_p.V151A|TRIM6_ENST00000506134.1_Missense_Mutation_p.V151A|TRIM6_ENST00000481603.1_3'UTR|TRIM6_ENST00000380107.1_Missense_Mutation_p.V300A|TRIM6_ENST00000515022.1_Missense_Mutation_p.V151A|HBG2_ENST00000380259.2_Intron|TRIM6-TRIM34_ENST00000354852.5_Intron	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTGAGGTTTGTGGGAGCTAAA	0.468000													10	47					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72964957	72964957	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:72964957G>C	ENST00000262209.4	-	14	1895	c.1688C>G	c.(1687-1689)gCc>gGc	p.A563G	RP11-383H13.1_ENST00000537896.1_3'UTR|RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	563						integral to plasma membrane		p.A563D(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AAGCGCAACGGCTTTGGCGTG	0.463000													11	129					0	0	1	0	0
CA1	759	broad.mit.edu	37	8	86250502	86250502	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:86250502C>T	ENST00000523953.1	-	4	1260	c.214G>A	c.(214-216)Gag>Aag	p.E72K	CA1_ENST00000542576.1_Missense_Mutation_p.E72K|CA1_ENST00000256119.5_Missense_Mutation_p.E72K|CA1_ENST00000431316.1_Missense_Mutation_p.E72K|CA1_ENST00000432364.2_Missense_Mutation_p.E72K|CA1_ENST00000523022.1_Missense_Mutation_p.E72K|CA1_ENST00000518341.1_5'UTR|CA1_ENST00000522389.1_Intron			P00915	CAH1_HUMAN	carbonic anhydrase I	72					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	13		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	TCGTTGTCCTCAAAATTTACA	0.388000													19	199					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714922	38714922	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:38714922C>G	ENST00000308742.4	+	3	1645	c.1329C>G	c.(1327-1329)tgC>tgG	p.C443W	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	443					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				AACTGAGTTGCTATGCAATTG	0.348000													65	106					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61935148	61935148	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:61935148T>C	ENST00000577390.1	-	3	1436	c.482A>G	c.(481-483)aAt>aGt	p.N161S	CDH8_ENST00000577730.1_Missense_Mutation_p.N161S|CDH8_ENST00000299345.6_Missense_Mutation_p.N161S|CDH8_ENST00000584337.1_Missense_Mutation_p.N161S	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	161	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGCATTGTCATTGATGTCTTG	0.403000													14	79					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47888227	47888227	+	Missense_Mutation	SNP	T	T	C	rs143179718		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:47888227T>C	ENST00000396105.1	-	3	368	c.122A>G	c.(121-123)aAt>aGt	p.N41S	ZNFX1_ENST00000371754.4_Missense_Mutation_p.N41S|ZNFX1_ENST00000371752.1_Missense_Mutation_p.N41S	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	41							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCGGAGAGCATTGGCTGGTGG	0.522000													11	107					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63052236	63052236	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:63052236C>T	ENST00000251157.5	-	15	1775	c.1742G>A	c.(1741-1743)aGa>aAa	p.R581K	DOCK7_ENST00000340370.5_Missense_Mutation_p.R581K|DOCK7_ENST00000404627.2_Missense_Mutation_p.R581K	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	581	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TGTTATATTTCTAGCAGAACC	0.333000													5	31					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406361	148406361	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:148406361A>G	ENST00000394358.2	-	12	3041	c.2589T>C	c.(2587-2589)caT>caC	p.H863H	SH3TC2_ENST00000538184.1_Intron|SH3TC2_ENST00000512049.1_Intron|SH3TC2_ENST00000515425.1_Intron			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	778							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGATAGGAAATGGATAAAAC	0.448000													21	100					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169582842	169582842	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:169582842C>A	ENST00000263686.6	-	4	608	c.571G>T	c.(571-573)Ggg>Tgg	p.G191W	SELP_ENST00000367793.2_Missense_Mutation_p.G191W|SELP_ENST00000458599.2_Missense_Mutation_p.G191W|SELP_ENST00000367794.2_Missense_Mutation_p.G191W|SELP_ENST00000367788.2_Missense_Mutation_p.G191W|SELP_ENST00000367792.2_Missense_Mutation_p.G191W|SELP_ENST00000367791.2_Missense_Mutation_p.G191W|SELP_ENST00000367786.2_Missense_Mutation_p.G191W	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	191	EGF-like.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CATTCTGGCCCATAGAATCCA	0.448000													10	108					0.000673444	0.000717774	1	1	0
MB21D2	151963	broad.mit.edu	37	3	192635661	192635661	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:192635661G>T	ENST00000392452.2	-	0	289					NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2											endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						CTCCGCGGCAGCGCGGCACCC	0.736000													4	10					0.000602214	0.000645472	1	1	0
SGIP1	84251	broad.mit.edu	37	1	67155965	67155965	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:67155965C>A	ENST00000371037.4	+	17	1613	c.1536C>A	c.(1534-1536)acC>acA	p.T512T	SGIP1_ENST00000371035.3_Silent_p.T302T|SGIP1_ENST00000371036.3_Silent_p.T312T|SGIP1_ENST00000371039.1_Silent_p.T313T|SGIP1_ENST00000237247.6_Silent_p.T543T	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	512					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TATCGTCAACCAATTCCTTGA	0.458000													28	205					9.04072e-19	1.24187e-18	1	1	0
MTG1	92170	broad.mit.edu	37	10	135209677	135209677	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:135209677C>G	ENST00000468317.2	+	4	458	c.203C>G	c.(202-204)tCa>tGa	p.S68*	MTG1_ENST00000317502.6_Nonsense_Mutation_p.S63*|MTG1_ENST00000477902.2_Nonsense_Mutation_p.S22*																							ATCCCACTTTCAGGCCGCAAC	0.468000													52	346					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175375360	175375360	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:175375360G>T	ENST00000367674.1	-	3	1199	c.491C>A	c.(490-492)gCt>gAt	p.A164D	TNR_ENST00000263525.2_Missense_Mutation_p.A164D	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	164	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACCTGTGGCAGCACTTTCTTG	0.617000													14	93					1.99824e-07	2.27303e-07	1	1	0
LRRN3	54674	broad.mit.edu	37	7	110764165	110764165	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:110764165C>A	ENST00000451085.1	+	4	2383	c.1337C>A	c.(1336-1338)gCt>gAt	p.A446D	IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000452895.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.A446D|LRRN3_ENST00000308478.5_Missense_Mutation_p.A446D|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000489381.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	446	Ig-like C2-type.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CACTGTAGAGCTACTGCAGAA	0.433000													22	159					9.39395e-14	1.20553e-13	1	1	0
FAM24A	118670	broad.mit.edu	37	10	124671262	124671262	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:124671262G>T	ENST00000368894.1	+	2	233	c.112G>T	c.(112-114)Gct>Tct	p.A38S		NM_001029888.1	NP_001025059.1	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	38						extracellular region				large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	9		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		CTTCAAAGTAGCTAAGGCACT	0.463000													79	484					7.0627e-44	1.088e-43	1	1	0
CRTC1	23373	broad.mit.edu	37	19	18888151	18888151	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:18888151G>A	ENST00000338797.6	+	15	1937	c.1912G>A	c.(1912-1914)Gac>Aac	p.D638N	CRTC1_ENST00000321949.8_Missense_Mutation_p.D622N|CRTC1_ENST00000594658.1_Missense_Mutation_p.D581N|CRTC1_ENST00000601916.1_Missense_Mutation_p.D380N	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	622					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						GGTTCTGGCCGACCCAGCCAC	0.687000													173	303					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380500	56380500	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:56380500G>A	ENST00000526538.1	-	1	478	c.479C>T	c.(478-480)tCa>tTa	p.S160L		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GGTTAGCAGTGACTGAGAGAA	0.473000													12	56					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344276	53344276	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:53344276G>C	ENST00000595646.1	-	4	1391	c.1271C>G	c.(1270-1272)tCa>tGa	p.S424*	ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Nonsense_Mutation_p.S371*|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Nonsense_Mutation_p.S371*			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TTCCAGGTTTGATTTGCGACT	0.413000													38	125					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511468	61511468	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:61511468C>A	ENST00000266070.4	-	16	6165	c.5840G>T	c.(5839-5841)gGa>gTa	p.G1947V	DIDO1_ENST00000395343.1_Missense_Mutation_p.G1947V	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1947	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCCTCTGGGTCCTTCAAACTG	0.577000													56	187					4.46356e-37	6.80715e-37	1	1	0
HMGB4	127540	broad.mit.edu	37	1	34329881	34329881	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:34329881A>T	ENST00000522796.1	+	4	1994	c.89A>T	c.(88-90)cAg>cTg	p.Q30L	HMGB4_ENST00000425537.1_3'UTR|CSMD2_ENST00000373381.4_Intron|HMGB4_ENST00000519684.1_Missense_Mutation_p.Q30L			B2R4X7	B2R4X7_HUMAN	high mobility group box 4	30						nucleus	DNA binding			NS(1)|breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TTCAAGGAGCAGCAGCCAAAT	0.393000													14	81					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6921855	6921855	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:6921855G>T	ENST00000312053.4	+	14	1789	c.1752G>T	c.(1750-1752)atG>atT	p.M584I	EMR1_ENST00000381407.5_Missense_Mutation_p.M443I|EMR1_ENST00000381404.4_Missense_Mutation_p.M532I|EMR1_ENST00000250572.8_Missense_Mutation_p.M584I|EMR1_ENST00000450315.3_Missense_Mutation_p.M407I	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	584	GPS.|Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					GTAATCAGATGGCAAATCTTG	0.483000													36	82					1.22674e-20	1.73846e-20	1	1	0
MSH3	4437	broad.mit.edu	37	5	80074609	80074609	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:80074609G>T	ENST00000265081.6	+	17	2469	c.2389G>T	c.(2389-2391)Gag>Tag	p.E797*		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	797					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TCAGCTCCGGGAGCAGCTAGT	0.398000								Mismatch excision repair (MMR)					14	82					4.14922e-12	5.1426e-12	1	1	0
SOGA2	23255	broad.mit.edu	37	18	8784440	8784440	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:8784440C>A	ENST00000359865.3	+	6	1472	c.1330C>A	c.(1330-1332)Ctc>Atc	p.L444I	SOGA2_ENST00000517570.1_Missense_Mutation_p.L444I|SOGA2_ENST00000306329.11_Missense_Mutation_p.L804I|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Missense_Mutation_p.L444I	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	795																	CCCCACGGAGCTCCTGAAGGC	0.642000													21	109					5.35356e-11	6.54993e-11	1	1	0
ADAM22	53616	broad.mit.edu	37	7	87564433	87564433	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:87564433G>T	ENST00000398204.4	+	2	501	c.178G>T	c.(178-180)Ggc>Tgc	p.G60C	ADAM22_ENST00000265727.7_Missense_Mutation_p.G60C|ADAM22_ENST00000315984.7_Missense_Mutation_p.G60C|ADAM22_ENST00000398209.3_Missense_Mutation_p.G60C|ADAM22_ENST00000398201.4_Missense_Mutation_p.G60C|ADAM22_ENST00000439864.1_Missense_Mutation_p.G60C	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	60					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CTACCGCTCGGGCGGCGAAGA	0.672000													31	34					1.08312e-15	1.42113e-15	1	1	0
CELF4	56853	broad.mit.edu	37	18	34839100	34839100	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:34839100G>T	ENST00000588597.1	-	11	1350	c.1341C>A	c.(1339-1341)aaC>aaA	p.N447K	CELF4_ENST00000601019.1_Intron|CELF4_ENST00000361795.5_Intron|CELF4_ENST00000420428.2_Intron|CELF4_ENST00000591282.1_Intron|CELF4_ENST00000603232.1_Intron|CELF4_ENST00000334919.5_Intron|CELF4_ENST00000591287.1_Intron|CELF4_ENST00000412753.1_Intron			Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	92	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						ATTTACTTTGGTTAGTCGCCC	0.507000													24	39					7.38237e-10	8.7644e-10	1	1	0
SPTBN2	6712	broad.mit.edu	37	11	66460553	66460553	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:66460553C>T	ENST00000533211.1	-	25	5204	c.4873G>A	c.(4873-4875)Gca>Aca	p.A1625T	SPTBN2_ENST00000309996.2_Missense_Mutation_p.A1625T|SPTBN2_ENST00000529997.1_Missense_Mutation_p.A1625T			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1625					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						TTCACCTCTGCCTGGGCACTC	0.627000													20	77					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65390520	65390520	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:65390520G>T	ENST00000519389.1	+	2	449	c.270G>T	c.(268-270)caG>caT	p.Q90H	HEPH_ENST00000419594.1_Missense_Mutation_p.Q39H|HEPH_ENST00000441993.2_Missense_Mutation_p.Q39H|HEPH_ENST00000343002.2_Missense_Mutation_p.Q36H|HEPH_ENST00000336279.5_Intron|HEPH_ENST00000374727.3_Missense_Mutation_p.Q39H			Q9BQS7	HEPH_HUMAN	hephaestin	36	Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GGGATGTGCAGTGGAACTATG	0.522000													11	12					0.000978159	0.00104109	1	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140794527	140794527	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140794527G>T	ENST00000398610.2	+	1	1785	c.1785G>T	c.(1783-1785)gtG>gtT	p.V595V	PCDHGA8_ENST00000398604.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCAAGGTGGTGGCGGTGG	0.701000													26	176					5.61819e-17	7.54046e-17	1	1	0
WHSC1L1	54904	broad.mit.edu	37	8	38146269	38146269	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:38146269G>C	ENST00000317025.8	-	19	3754	c.3237C>G	c.(3235-3237)aaC>aaG	p.N1079K	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.N1079K|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.N1030K	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	1079					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CTATTACTTTGTTAGCCTAGA	0.488000			T	NUP98	AML								14	100					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38838183	38838183	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:38838183G>A	ENST00000359357.3	+	47	6438	c.6184G>A	c.(6184-6186)Gaa>Aaa	p.E2062K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E2279K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E2026K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTAGGTTGATGAAGATGAACC	0.408000													37	117					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133622721	133622721	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:133622721G>A	ENST00000253861.4	+	14	2134	c.2105G>A	c.(2104-2106)cGt>cAt	p.R702H	EXOC4_ENST00000541309.1_5'UTR|EXOC4_ENST00000539845.1_Missense_Mutation_p.R601H|EXOC4_ENST00000545148.1_Missense_Mutation_p.R312H	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	702					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GACATCCTTCGTGACGTCAGT	0.458000													22	183					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44777742	44777742	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:44777742G>A	ENST00000391958.2	+	5	1056	c.929G>A	c.(928-930)gGa>gAa	p.G310E	ZNF233_ENST00000334152.1_Missense_Mutation_p.G292E|ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000592581.1_3'UTR	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				TTCCACATAGGAGAGAAATGC	0.493000													19	59					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10225956	10225956	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:10225956G>T	ENST00000315330.4	-	5	660	c.598C>A	c.(598-600)Ctt>Att	p.L200I	CLEC1A_ENST00000457018.2_Missense_Mutation_p.L167I|CLEC1A_ENST00000420265.2_Missense_Mutation_p.L108I	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	200	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						GGGCGCAAAAGCCCTGTCCAA	0.453000													16	58					1.5739e-10	1.89815e-10	1	1	0
XPC	7508	broad.mit.edu	37	3	14193877	14193877	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:14193877C>A	ENST00000285021.7	-	11	2287	c.2073G>T	c.(2071-2073)ctG>ctT	p.L691L	XPC_ENST00000449060.2_Silent_p.L654L	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	691	DNA-binding; preference for heteroduplex DNA.|Interaction with RAD23B.|Minimal sensor domain involved in damage recognition.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGCTTTCTTCAGCCACGTGT	0.577000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				3	34					0.004672	0.0048704	1	1	0
BGN	633	broad.mit.edu	37	X	152773768	152773768	+	Silent	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:152773768C>G	ENST00000331595.4	+	8	1158	c.972C>G	c.(970-972)ggC>ggG	p.G324G	BGN_ENST00000480756.1_3'UTR|BGN_ENST00000370204.1_Silent_p.G263G	NM_001711.4	NP_001702.1	P21810	PGS1_HUMAN	biglycan	324						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCCCATGGGCTTCGGGGTGA	0.612000													57	142					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097384	167097384	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:167097384C>A	ENST00000361200.2	+	6	3182	c.3016C>A	c.(3016-3018)Cgg>Agg	p.R1006R	DUSP27_ENST00000271385.5_Silent_p.R1006R|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Silent_p.R1006R			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1006	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AAGCACTTCACGGTTCTCATC	0.527000													71	81					2.72187e-29	4.06943e-29	1	1	0
NELL1	4745	broad.mit.edu	37	11	20869300	20869300	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:20869300G>T	ENST00000298925.5	+	5	743		c.e5+1		NELL1_ENST00000357134.5_Splice_Site|NELL1_ENST00000325319.5_Intron|NELL1_ENST00000532434.1_Splice_Site			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)						cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						ACTGTAACAGGTATTTCTTTG	0.453000													3	20					1	1	1	1	0
PXK	54899	broad.mit.edu	37	3	58381406	58381406	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:58381406C>T	ENST00000463280.1	+	7	734	c.643C>T	c.(643-645)Cta>Tta	p.L215L	PXK_ENST00000479241.1_Silent_p.L231L|PXK_ENST00000484288.1_Silent_p.L248L|PXK_ENST00000383716.3_Silent_p.L215L|PXK_ENST00000356151.2_Silent_p.L248L|PXK_ENST00000536660.1_Silent_p.L111L|PXK_ENST00000302779.5_Silent_p.L231L|PXK_ENST00000383715.4_Silent_p.L231L			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	248	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AGACCCATTTCTAAAGAAGTA	0.428000													10	72					0	0	1	0	0
BCL2L2	599	broad.mit.edu	37	14	23778060	23778060	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:23778060G>T	ENST00000250405.5	+	4	697	c.468G>T	c.(466-468)ctG>ctT	p.L156L	BCL2L2-PABPN1_ENST00000557008.1_Intron|BCL2L2-PABPN1_ENST00000553781.1_Intron	NM_001199839.1|NM_004050.4	NP_001186768.1|NP_004041.1			BCL2-like 2											central_nervous_system(1)|lung(4)|prostate(1)	6	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00654)		ACGGGGCCCTGGAGGAGGCGC	0.622000													43	63					1.54043e-34	2.32593e-34	1	1	0
DCDC1	341019	broad.mit.edu	37	11	30953366	30953366	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:30953366C>G	ENST00000597505.1	-	20	2848	c.2849G>C	c.(2848-2850)aGa>aCa	p.R950T	DCDC1_ENST00000339794.5_Missense_Mutation_p.R29T|DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	188					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					AGTAACGGATCTGTTTTTATT	0.423000													6	48					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31024197	31024197	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:31024197G>A	ENST00000375687.4	+	13	4106	c.3682G>A	c.(3682-3684)Gaa>Aaa	p.E1228K	ASXL1_ENST00000306058.5_Missense_Mutation_p.E1223K	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1228					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						GAAACTGGAAGAAATGGATTC	0.463000			"""F, N, Mis"""		"""MDS, CMML"""								17	90					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291465	33291465	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:33291465G>A	ENST00000280979.4	+	13	4616	c.4446G>A	c.(4444-4446)atG>atA	p.M1482I	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1482					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AATTACCAATGATAATGAAAC	0.358000													10	29					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	872020	872020	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:872020C>T	ENST00000312090.6	-	12	2154	c.2004G>A	c.(2002-2004)ctG>ctA	p.L668L	MED16_ENST00000395808.3_Silent_p.L668L|MED16_ENST00000589119.1_Silent_p.L668L|MED16_ENST00000325464.1_Silent_p.L668L|MED16_ENST00000269814.4_Intron			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	668					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGGCTTCAGAAGGCCCC	0.632000													11	36					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37266571	37266571	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:37266571C>T	ENST00000397147.4	+	5	641	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C	NCF4_ENST00000248899.6_Missense_Mutation_p.R153C	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	153			R -> H (in dbSNP:rs35160112).		cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						GCTCCGCCCGCGCACCCGGAA	0.617000													30	49					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670794	134670794	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:134670794C>A	ENST00000398015.3	+	3	1075	c.705C>A	c.(703-705)ccC>ccA	p.P235P	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	235	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TGGACGTGCCCATCAAACTCT	0.557000													120	240					1.88711e-46	2.91297e-46	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118567936	118567936	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:118567936G>T	ENST00000336338.5	-	27	3899	c.3834C>A	c.(3832-3834)ccC>ccA	p.P1278P		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1278						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCTGCTCTGCGGGTGGCATCA	0.458000													25	44					1.13719e-10	1.37584e-10	1	1	0
MAS1L	116511	broad.mit.edu	37	6	29455370	29455370	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:29455370C>G	ENST00000377127.3	-	1	368	c.310G>C	c.(310-312)Gcc>Ccc	p.A104P		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	104						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GGATTCGTGGCCCCACAGCAA	0.552000													15	54					0	0	1	0	0
NCR1	9437	broad.mit.edu	37	19	55418152	55418152	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:55418152T>A	ENST00000594765.1	+	3	367	c.342T>A	c.(340-342)gaT>gaA	p.D114E	NCR1_ENST00000447255.1_Missense_Mutation_p.D114E|NCR1_ENST00000598576.1_Missense_Mutation_p.D102E|NCR1_ENST00000350790.5_Intron|NCR1_ENST00000291890.4_Missense_Mutation_p.D114E|NCR1_ENST00000338835.5_Missense_Mutation_p.D114E|NCR1_ENST00000357397.5_Intron			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	114	Ig-like 1.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		ACTTGCTGGATCTGGTGGTAA	0.527000													37	102					0	0	1	0	0
CD82	3732	broad.mit.edu	37	11	44626732	44626732	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:44626732G>T	ENST00000227155.4	+	5	509	c.261_splice	c.e5+1	p.L87_splice	CD82_ENST00000530931.1_3'UTR|RP11-58K22.5_ENST00000533814.1_RNA|CD82_ENST00000342935.3_Splice_Site_p.L87_splice	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	87						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						TGCTGGGGCTGGTGAGTACGG	0.652000													5	60					5.9392e-07	6.7158e-07	1	1	0
NLRC5	84166	broad.mit.edu	37	16	57060811	57060811	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:57060811C>T	ENST00000436936.1	+	6	2181	c.1956C>T	c.(1954-1956)gcC>gcT	p.A652A	NLRC5_ENST00000539144.1_Silent_p.A652A|NLRC5_ENST00000262510.6_Silent_p.A652A|NLRC5_ENST00000308149.7_Silent_p.A652A			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	652					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				CCGACCTGGCCACCCTGACCA	0.607000													50	134					0	0	1	0	0
WNT4	54361	broad.mit.edu	37	1	22456245	22456245	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:22456245C>T	ENST00000290167.6	-	2	220	c.177G>A	c.(175-177)cgG>cgA	p.R59R	WNT4_ENST00000542383.1_Silent_p.R4R	NM_030761.4	NP_110388.2	P56705	WNT4_HUMAN	wingless-type MMTV integration site family, member 4	59					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	8		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CTTCCAGGTTCCGCTTGCACA	0.627000													35	159					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45026873	45026873	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:45026873C>A	ENST00000454753.1	-	0	819							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane		p.E181K(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CTGGAGCCCTCCATCACCTCA	0.498000													3	22					0.115264	0.116643	1	1	0
TTLL9	164395	broad.mit.edu	37	20	30510853	30510853	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:30510853G>C	ENST00000375938.4	+	8	914	c.661G>C	c.(661-663)Gga>Cga	p.G221R	TTLL9_ENST00000375922.4_Missense_Mutation_p.G148R|TTLL9_ENST00000375934.4_Missense_Mutation_p.G203R|TTLL9_ENST00000535842.1_Missense_Mutation_p.G221R|TTLL9_ENST00000310998.4_Missense_Mutation_p.G171R|TTLL9_ENST00000375921.2_Missense_Mutation_p.G148R			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	221	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTACCTGATAGGAGGTGAGAT	0.483000													15	115					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22382497	22382497	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:22382497G>A	ENST00000263160.3	+	5	1065	c.628G>A	c.(628-630)Gag>Aag	p.E210K		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	210					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						CCCACCTCTAGAGAGGAGTAG	0.473000													12	79					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33630903	33630903	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:33630903A>G	ENST00000504830.1	-	13	2339	c.2004T>C	c.(2002-2004)tgT>tgC	p.C668C	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Intron	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	668	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TGCCATTAATACAGACATTTC	0.393000										HNSCC(64;0.19)			34	72					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3644562	3644562	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:3644562C>T	ENST00000294008.3	-	10	2692	c.2052G>A	c.(2050-2052)atG>atA	p.M684I		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	684	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GGTTATTGACCATGGCGCCAA	0.592000								Direct reversal of damage					9	97					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242423696	242423696	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:242423696G>A	ENST00000264042.3	+	21	2541	c.2371G>A	c.(2371-2373)Ggg>Agg	p.G791R		NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	791	PH 1.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGGAGTTGCAGGGACCAGCCA	0.537000													26	68					0	0	1	0	0
DHFR	1719	broad.mit.edu	37	5	79929790	79929790	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:79929790G>A	ENST00000439211.2	-	5	884	c.391C>T	c.(391-393)Cat>Tat	p.H131Y	DHFR_ENST00000504396.1_Missense_Mutation_p.H79Y|DHFR_ENST00000511032.1_Intron|DHFR_ENST00000513048.1_5'UTR|DHFR_ENST00000505337.1_Missense_Mutation_p.H131Y	NM_000791.3	NP_000782.1	P00374	DYR_HUMAN	dihydrofolate reductase	131	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding			kidney(1)|large_intestine(1)	2		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	AGTTTAAGATGGCCTGGGTGA	0.328000													11	35					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229882	140229882	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140229882C>T	ENST00000378122.3	+	1	2526	c.1802C>T	c.(1801-1803)tCg>tTg	p.S601L	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S601L|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCCGACTCGGGCTACAAC	0.677000													21	112					0	0	1	0	0
SYNE4	163183	broad.mit.edu	37	19	36497349	36497349	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:36497349G>C	ENST00000324444.3	-	5	954	c.843C>G	c.(841-843)ccC>ccG	p.P281P	SYNE4_ENST00000340477.5_Silent_p.P168P	NM_001039876.1	NP_001034965.1			spectrin repeat containing, nuclear envelope family member 4																		CCCTGCCCTGGGGCCCCCTCT	0.647000													13	54					0	0	1	0	0
BPIFC	254240	broad.mit.edu	37	22	32811906	32811906	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:32811906A>G	ENST00000397452.1	-	15	1507	c.1397T>C	c.(1396-1398)cTt>cCt	p.L466P	BPIFC_ENST00000534972.1_Missense_Mutation_p.L190P|BPIFC_ENST00000432451.2_Missense_Mutation_p.L223P|BPIFC_ENST00000300399.3_Missense_Mutation_p.L466P			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C	466						extracellular region	lipopolysaccharide binding|phospholipid binding										TCTTACCTCAAGAACTTCAAT	0.343000													8	14					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130910655	130910655	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:130910655G>A	ENST00000409031.1	-	19	3380	c.2232C>T	c.(2230-2232)gtC>gtT	p.V744V	SMPD4_ENST00000426662.2_Silent_p.V380V|SMPD4_ENST00000431183.2_Silent_p.V642V|SMPD4_ENST00000452225.2_Silent_p.V485V|SMPD4_ENST00000453750.1_Silent_p.V493V|SMPD4_ENST00000339679.7_Silent_p.V602V|SMPD4_ENST00000351288.6_Silent_p.V715V|SMPD4_ENST00000443958.2_Silent_p.V408V	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	705					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	AGAGTGTGCGGACCAAGCTGG	0.577000													27	183					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140063	54140063	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:54140063C>A	ENST00000376650.1	+	3	448	c.397C>A	c.(397-399)Ctg>Atg	p.L133M		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	133						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CCAGCTCATCCTGTACCCCAA	0.537000													33	173					4.62619e-21	6.63e-21	1	1	0
SCN9A	6335	broad.mit.edu	37	2	167129194	167129194	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:167129194C>A	ENST00000375387.4	-	17	3409	c.3069G>T	c.(3067-3069)agG>agT	p.R1023S	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1011S|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1022S|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1023S			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1022						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	GTCTTATCTCCCTGGAAATCT	0.328000													3	14					0.00024832	0.000268045	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22941213	22941213	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:22941213T>C	ENST00000397104.3	-	5	1224	c.1225A>G	c.(1225-1227)Aag>Gag	p.K409E	ZNF99_ENST00000596209.1_Missense_Mutation_p.K500E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGAATTACCTTATGTACAGTA	0.353000													8	14					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382642	22382642	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:22382642C>A	ENST00000328795.4	+	1	261	c.170C>A	c.(169-171)gCc>gAc	p.A57D	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGGCTCACAGCCCCCCTCTAT	0.463000													16	373					1.75199e-13	2.22953e-13	1	1	0
CR1	1378	broad.mit.edu	37	1	207789974	207789974	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:207789974C>A	ENST00000367049.4	+	41	6716	c.6716C>A	c.(6715-6717)cCc>cAc	p.P2239H	CR1_ENST00000367052.1_Missense_Mutation_p.P1789H|CR1_ENST00000367053.1_Missense_Mutation_p.P1789H|CR1_ENST00000400960.2_Missense_Mutation_p.P1789H|CR1_ENST00000367051.1_Missense_Mutation_p.P1789H	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1789					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACAGGAACTCCCTTTGGAGAT	0.428000													23	180					1.64293e-13	2.09777e-13	1	1	0
CDC27	996	broad.mit.edu	37	17	45214547	45214547	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:45214547G>A	ENST00000066544.3	-	14	1977	c.1884C>T	c.(1882-1884)atC>atT	p.I628I	CDC27_ENST00000531206.1_Silent_p.I634I|CDC27_ENST00000446365.2_Silent_p.I567I|CDC27_ENST00000527547.1_Silent_p.I627I	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	628					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						GATTGACTCTGATAGCATTTC	0.348000													4	33					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100912025	100912025	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:100912025G>T	ENST00000328766.5	-	5	1003	c.550C>A	c.(550-552)Cct>Act	p.P184T	ARMCX2_ENST00000330154.2_Missense_Mutation_p.P184T|ARMCX2_ENST00000356824.4_Missense_Mutation_p.P184T	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	184	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GCTTCGGTAGGCACCACTGTC	0.657000													7	23					0.000274275	0.000295224	1	1	0
ZNF438	220929	broad.mit.edu	37	10	31138002	31138002	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:31138002T>A	ENST00000538351.1	-	7	1939	c.1185A>T	c.(1183-1185)atA>atT	p.I395I	ZNF438_ENST00000436087.2_Silent_p.I444I|ZNF438_ENST00000375311.1_Silent_p.I8I|ZNF438_ENST00000331737.6_Silent_p.I434I|ZNF438_ENST00000452305.1_Silent_p.I434I|ZNF438_ENST00000413025.1_Silent_p.I444I|ZNF438_ENST00000444692.2_Silent_p.I434I|ZNF438_ENST00000361310.3_Silent_p.I444I|ZNF438_ENST00000442986.1_Silent_p.I444I	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				CCAAAGTGGGTATGACCATGA	0.438000													47	53					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48690397	48690397	+	Splice_Site	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:48690397C>T	ENST00000236495.5	+	2	214	c.162_splice	c.e2-1	p.S55_splice	SLC5A9_ENST00000420136.2_Splice_Site_p.S48_splice|SLC5A9_ENST00000438567.2_Splice_Site_p.S55_splice|SLC5A9_ENST00000533824.1_Splice_Site_p.S55_splice	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	55						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						CCTTTCCAGTCGTCCATCCGT	0.572000													14	88					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149642	18149642	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:18149642G>T	ENST00000375406.1	+	2	355	c.139G>T	c.(139-141)Gcc>Tcc	p.A47S		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	47						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCCCAGCTATGCCCGTAGGCG	0.592000													22	145					8.24728e-16	1.08962e-15	1	1	0
USP29	57663	broad.mit.edu	37	19	57640201	57640201	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:57640201T>A	ENST00000254181.4	+	4	612	c.158T>A	c.(157-159)cTg>cAg	p.L53Q	USP29_ENST00000598197.1_Missense_Mutation_p.L53Q	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	53					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTTTTCAGCTGAGCAACAAC	0.333000													9	29					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112924279	112924279	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:112924279G>T	ENST00000351677.2	+	11	1423	c.1224_splice	c.e11-1	p.G409_splice	PTPN11_ENST00000392597.1_Splice_Site_p.G409_splice	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	413	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						TCTACTCCAGGGGAATACGGA	0.527000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				6	66					0.00307968	0.00323707	1	1	0
SLC41A3	54946	broad.mit.edu	37	3	125725351	125725351	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:125725351C>T	ENST00000315891.6	-	12	1661	c.1423G>A	c.(1423-1425)Gga>Aga	p.G475R	SLC41A3_ENST00000360370.4_3'UTR|SLC41A3_ENST00000383598.2_3'UTR|SLC41A3_ENST00000346785.5_Missense_Mutation_p.G439R	NM_001008485.1|NM_017836.3	NP_001008485.1|NP_060306.3	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	475						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		AGGCCCCATCCTGGGGAGGCT	0.473000													10	53					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636835	152636835	+	Missense_Mutation	SNP	G	G	A	rs113433987		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:152636835G>A	ENST00000368784.1	+	2	309	c.254G>A	c.(253-255)cGg>cAg	p.R85Q		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	85	Cys-rich.				keratinization			p.R85Q(1)		large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCGGCGCCGGCACCAGAGC	0.677000													18	113					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7798322	7798322	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:7798322G>A	ENST00000380358.4	+	9	1535	c.1534G>A	c.(1534-1536)Gat>Aat	p.D512N	CHD3_ENST00000330494.7_Missense_Mutation_p.D453N|CHD3_ENST00000358181.4_Missense_Mutation_p.D453N	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	453	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				ggaggaggaggaTGATCACAT	0.577000													15	63					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993430	28993430	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:28993430C>T	ENST00000359747.4	+	15	3081	c.3052C>T	c.(3052-3054)Cca>Tca	p.P1018S	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.P999S|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	999					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTTAGTAGGGCCAGAAATTCA	0.493000													26	158					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123465533	123465533	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:123465533G>A	ENST00000529750.1	+	5	758	c.431G>A	c.(430-432)cGc>cAc	p.R144H	GRAMD1B_ENST00000322282.7_Missense_Mutation_p.R144H|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.R151H	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	144	GRAM.					integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		AACATCTTCCGCTGGGAAACT	0.507000													11	78					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249728	140249728	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140249728C>T	ENST00000398640.2	+	1	1040	c.1040C>T	c.(1039-1041)cCt>cTt	p.P347L	PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAACTCTCCTGAAGTCGCC	0.527000													33	66					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70504865	70504865	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:70504865C>A	ENST00000457664.2	-	1	493	c.494G>T	c.(493-495)gGt>gTt	p.G165V	UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.G366V	NM_001105677.2	NP_001099147.2																					AACAAGATCACCACAGATTGT	0.428000													7	40					0.000157383	0.000170611	1	1	0
ZIC1	7545	broad.mit.edu	37	3	147128529	147128529	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:147128529C>T	ENST00000282928.4	+	1	1359	c.630C>T	c.(628-630)gcC>gcT	p.A210A		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	210					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						ATCACGGCGCCGGCGCCTTCT	0.632000													17	44					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24228512	24228512	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:24228512G>A	ENST00000379177.1	+	11	1864	c.1437G>A	c.(1435-1437)aaG>aaA	p.K479K	ZFX_ENST00000304543.5_Silent_p.K479K|ZFX_ENST00000540034.1_Silent_p.K518K|ZFX_ENST00000539115.1_Silent_p.K250K|ZFX_ENST00000379188.3_Silent_p.K479K|ZFX_ENST00000338565.3_Silent_p.K429K	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						AGAGCCACAAGCTGACCAGCA	0.463000													8	24					0	0	1	0	0
SPEM1	374768	broad.mit.edu	37	17	7324694	7324694	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:7324694C>A	ENST00000323675.3	+	3	725	c.700C>A	c.(700-702)Cag>Aag	p.Q234K	RP11-104H15.7_ENST00000575310.1_RNA	NM_199339.2	NP_955371.2	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	234					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	12		Prostate(122;0.173)				AGAGGCGGCTCAGTACCAGCC	0.637000													21	19					2.98393e-07	3.37912e-07	1	1	0
CCDC170	80129	broad.mit.edu	37	6	151917629	151917629	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:151917629G>T	ENST00000367290.5	+	9	1716	c.1627G>T	c.(1627-1629)Gag>Tag	p.E543*	CCDC170_ENST00000239374.7_Nonsense_Mutation_p.E543*			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	543																	GAAGAAGGTGGAGAGGCTGCA	0.547000													35	70					1.32136e-16	1.76413e-16	1	1	0
DUPD1	338599	broad.mit.edu	37	10	76803716	76803716	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:76803716G>A	ENST00000338487.5	-	2	259	c.260C>T	c.(259-261)gCg>gTg	p.A87V		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	87	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GCCGTGGGCCGCGTTCAGCAC	0.692000													13	40					0	0	1	0	0
GUCA1B	2979	broad.mit.edu	37	6	42153463	42153463	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:42153463C>G	ENST00000230361.3	-	3	525	c.430G>C	c.(430-432)Gag>Cag	p.E144Q		NM_002098.5	NP_002089.4	Q9UMX6	GUC1B_HUMAN	guanylate cyclase activator 1B (retina)	144	EF-hand 4.				body fluid secretion|cell-cell signaling|receptor guanylyl cyclase signaling pathway|visual perception	plasma membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			large_intestine(3)|lung(3)|skin(2)	8	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00154)|STAD - Stomach adenocarcinoma(11;0.00177)			TCCACGACCTCCTCGGGTGTG	0.547000													45	40					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495810	71495810	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:71495810C>A	ENST00000296755.7	+	5	6926	c.6628C>A	c.(6628-6630)Cct>Act	p.P2210T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2210						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGACCGCAGCCCTTCGCCACG	0.542000													68	163					1.11057e-38	1.69708e-38	1	1	0
FAM217A	222826	broad.mit.edu	37	6	4077607	4077607	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:4077607C>A	ENST00000274673.3	-	2	445	c.42G>T	c.(40-42)gtG>gtT	p.V14V	FAM217A_ENST00000380188.2_Intron	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	14																	AGATGTTTGACACACGTAGGC	0.473000													48	159					7.06795e-37	1.07359e-36	1	1	0
MS4A14	84689	broad.mit.edu	37	11	60165372	60165372	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:60165372A>G	ENST00000300187.6	+	2	463	c.186A>G	c.(184-186)atA>atG	p.I62M	MS4A14_ENST00000531787.1_Intron|MS4A14_ENST00000395001.1_5'UTR|MS4A14_ENST00000531783.1_Missense_Mutation_p.I62M|MS4A14_ENST00000395005.2_Missense_Mutation_p.I62M	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	62						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						TTGGAACTATATTTGCACTTA	0.453000													3	82					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69158622	69158622	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:69158622G>A	ENST00000398004.2	+	5	1166	c.894G>A	c.(892-894)aaG>aaA	p.K298K	SLC35E3_ENST00000538043.1_Intron	NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	298						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			CCCACTTTAAGCTCAGTGAAC	0.378000													12	81					0	0	1	0	0
KLK11	11012	broad.mit.edu	37	19	51527500	51527500	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:51527500T>A	ENST00000594768.1	-	4	545	c.360A>T	c.(358-360)acA>acT	p.T120T	KLK11_ENST00000319720.7_Silent_p.T88T|KLK11_ENST00000594458.1_5'UTR|KLK11_ENST00000453757.3_Silent_p.T88T|KLK11_ENST00000600362.1_Intron|KLK11_ENST00000391804.3_Silent_p.T113T	NM_144947.1	NP_659196.1	Q9UBX7	KLK11_HUMAN	kallikrein-related peptidase 11	120	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		ACTCAGTGGCTGTCCGGGTCT	0.582000													57	147					0	0	1	0	0
AC010731.4	0	broad.mit.edu	37	2	207508987	207508987	+	RNA	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:207508987G>T	ENST00000543490.1	+	0	202																											ACAGAGGAGGGATCCACCGCC	0.502000													10	34					4.36969e-10	5.21212e-10	1	1	0
ZNF667	63934	broad.mit.edu	37	19	56973780	56973780	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:56973780G>T	ENST00000591790.1	-	0	1388				ZNF667_ENST00000292069.6_De_novo_Start_OutOfFrame|ZNF667_ENST00000504904.3_De_novo_Start_OutOfFrame|ZNF667_ENST00000342634.3_Missense_Mutation_p.S80Y			Q5HYK9	ZN667_HUMAN	zinc finger protein 667						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GAGATGGGCAGAGAGCTGGTA	0.562000													23	154					2.48779e-11	3.06345e-11	1	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125204376	125204376	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:125204376G>T	ENST00000431078.1	+	6	1144	c.780G>T	c.(778-780)ctG>ctT	p.L260L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	260	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTGCCACCCTGGGCAGCCTCC	0.602000													47	72					1.81118e-26	2.66083e-26	1	1	0
NHSL2	340527	broad.mit.edu	37	X	71358694	71358694	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:71358694T>A	ENST00000373677.1	+	2	1460	c.198T>A	c.(196-198)ccT>ccA	p.P66P	NHSL2_ENST00000535692.1_Silent_p.P66P|NHSL2_ENST00000510661.1_Silent_p.P201P|NHSL2_ENST00000540800.1_Silent_p.P432P			F5H593	F5H593_HUMAN	NHS-like 2	432										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					AAGTCCCACCTCTGGTTCCTA	0.517000													17	15					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179348562	179348562	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:179348562G>A	ENST00000367618.3	+	6	913	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K	AXDND1_ENST00000457238.2_Missense_Mutation_p.E176K|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	176										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TTTGATTCCTGAAGAATTTCA	0.333000													9	70					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89986689	89986689	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:89986689A>G	ENST00000405460.2	+	31	6878	c.6782A>G	c.(6781-6783)aAt>aGt	p.N2261S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2261					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATAATTCGAAATTCTGGGACA	0.443000													3	20					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128487899	128487899	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:128487899G>T	ENST00000325888.8	+	25	4698	c.4437G>T	c.(4435-4437)gtG>gtT	p.V1479V	FLNC_ENST00000346177.6_Silent_p.V1479V	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1479					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCCTGCAGGTGGCTGTGCTGG	0.697000													10	108					1.5739e-10	1.89815e-10	1	1	0
OR7E91P	79315	broad.mit.edu	37	2	71256941	71256941	+	RNA	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:71256941G>A	ENST00000434990.1	-	0	61																											CTGAGAAACAGGGACATTCAA	0.527000													6	22					0	0	1	0	0
RP11-464F9.1	0	broad.mit.edu	37	10	75487170	75487170	+	RNA	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:75487170T>A	ENST00000399449.3	-	0	307				BMS1P4_ENST00000584747.1_RNA|RP11-574K11.28_ENST00000580790.1_RNA																							ACTACCACTATTGGTGGGGGC	0.438000													21	133					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141294005	141294005	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:141294005G>A	ENST00000389328.4	-	14	2405	c.2391C>T	c.(2389-2391)atC>atT	p.I797I	TRAPPC9_ENST00000389327.3_Silent_p.I690I|TRAPPC9_ENST00000438773.2_Silent_p.I699I	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	699					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GAGAGGTGCTGATCTGCAGTC	0.488000													22	141					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58126079	58126079	+	Missense_Mutation	SNP	G	G	T	rs139841692		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:58126079G>T	ENST00000357377.3	-	1	463	c.464C>A	c.(463-465)tCt>tAt	p.S155Y		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AATTTGGATAGAAGCATTCAG	0.438000													8	99					0.0477658	0.048531	1	1	0
CEBPZ	10153	broad.mit.edu	37	2	37439112	37439112	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:37439112C>T	ENST00000234170.5	-	12	2819	c.2674G>A	c.(2674-2676)Gaa>Aaa	p.E892K	AC007390.5_ENST00000397064.2_Intron|RP11-423P10.2_ENST00000606229.1_RNA	NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	892					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTACCAAGTTCATCATCACTA	0.358000													14	39					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493627	55493627	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:55493627G>T	ENST00000543010.1	+	6	704	c.561G>T	c.(559-561)gaG>gaT	p.E187D	NLRP2_ENST00000448584.2_Missense_Mutation_p.E187D|NLRP2_ENST00000391721.4_Missense_Mutation_p.E163D|NLRP2_ENST00000427260.2_Missense_Mutation_p.E164D|NLRP2_ENST00000538819.1_Missense_Mutation_p.E163D|NLRP2_ENST00000263437.6_Missense_Mutation_p.E184D|NLRP2_ENST00000339757.7_Missense_Mutation_p.E165D|NLRP2_ENST00000537859.1_Missense_Mutation_p.E165D	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	187					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TTATGGCTGAGAGATACAAGA	0.517000													39	307					4.44401e-20	6.21672e-20	1	1	0
LPPR4	9890	broad.mit.edu	37	1	99771889	99771889	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:99771889G>A	ENST00000370185.3	+	7	2112	c.1615G>A	c.(1615-1617)Gag>Aag	p.E539K	LPPR4_ENST00000457765.1_Missense_Mutation_p.E481K|LPPR4_ENST00000370184.1_Missense_Mutation_p.E381K	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		539							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CATCCCTGAGGAGACTCAGGA	0.557000													75	165					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408040	107408040	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:107408040C>T	ENST00000340010.5	-	20	2439	c.2255G>A	c.(2254-2256)cGt>cAt	p.R752H	SLC26A3_ENST00000422236.2_Missense_Mutation_p.R639H	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	752					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TACCCGATTACGTAATCCTCC	0.343000													12	22					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53186082	53186082	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:53186082G>T	ENST00000417996.2	-	5	1203	c.1129C>A	c.(1129-1131)Cag>Aag	p.Q377K	KRT3_ENST00000309505.3_Missense_Mutation_p.Q377K	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	377	Coil 2.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCCTCATACTGTGCACGAACT	0.532000													17	48					1.56452e-12	1.95823e-12	1	1	0
FAM83C	128876	broad.mit.edu	37	20	33875411	33875411	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:33875411G>C	ENST00000374408.3	-	4	1267	c.1171C>G	c.(1171-1173)Cag>Gag	p.Q391E		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	391										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AGGGAGGGCTGGCCACTGGCC	0.637000													7	39					0	0	1	0	0
STEAP1B	256227	broad.mit.edu	37	7	22533417	22533417	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:22533417A>G	ENST00000404369.4	-	3	538	c.123T>C	c.(121-123)ccT>ccC	p.P41P	STEAP1B_ENST00000406890.2_Intron	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	28						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						GCAAAAGCACAGGTCTTTTTA	0.428000													36	130					0	0	1	0	0
P2RX6	9127	broad.mit.edu	37	22	21380781	21380781	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:21380781G>A	ENST00000413302.2	+	12	1349	c.1201G>A	c.(1201-1203)Gag>Aag	p.E401K	P2RX6_ENST00000402329.3_3'UTR|P2RX6_ENST00000443995.3_Missense_Mutation_p.E348K|P2RX6_ENST00000336296.2_Missense_Mutation_p.E391K|P2RX6_ENST00000401443.1_Missense_Mutation_p.E375K			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	401					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										CCGACTGGCCGAGTGCCTCAG	0.627000													6	25					0	0	1	0	0
EDA	1896	broad.mit.edu	37	X	68836338	68836338	+	Silent	SNP	A	A	T	rs41539891		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:68836338A>T	ENST00000374552.4	+	1	428	c.186A>T	c.(184-186)ctA>ctT	p.L62L	EDA_ENST00000338901.3_Silent_p.L62L|EDA_ENST00000527388.1_Silent_p.L62L|EDA_ENST00000525810.1_Silent_p.L62L|EDA_ENST00000374553.2_Silent_p.L62L|EDA_ENST00000502251.1_3'UTR|EDA_ENST00000524573.1_Silent_p.L62L	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	62					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						GCTGCTACCTAGAGTTGCGCT	0.692000													29	12					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626733	49626733	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:49626733G>A	ENST00000371571.4	-	2	428	c.143C>T	c.(142-144)cCg>cTg	p.P48L	KCNG1_ENST00000396017.3_Missense_Mutation_p.P48L	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	48						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CTCATCCTGCGGCCGCAGCCG	0.711000													10	28					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14741351	14741351	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:14741351C>A	ENST00000403951.2	-	7	890	c.471G>T	c.(469-471)atG>atT	p.M157I	DGKB_ENST00000399322.3_Missense_Mutation_p.M157I|DGKB_ENST00000444700.2_Missense_Mutation_p.M150I|DGKB_ENST00000402815.1_Missense_Mutation_p.M157I|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000406247.3_Missense_Mutation_p.M157I|DGKB_ENST00000258767.5_Missense_Mutation_p.M157I|DGKB_ENST00000407950.1_Missense_Mutation_p.M150I			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	157	EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	AAAGGCGAAACATAACTAGAA	0.313000													9	78					2.80697e-09	3.27624e-09	1	1	0
MIR513A2	574510	broad.mit.edu	37	X	146307394	146307394	+	RNA	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:146307394A>T	ENST00000385249.1	-	0	76					NR_030232.1																						cagaaaggtgaaatttatatt	0.458000													22	26					0	0	1	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49967388	49967388	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:49967388C>T	ENST00000293350.4	+	10	1362	c.1199C>T	c.(1198-1200)cCg>cTg	p.P400L	ALDH16A1_ENST00000455361.2_Missense_Mutation_p.P349L|ALDH16A1_ENST00000540132.1_Missense_Mutation_p.P237L|ALDH16A1_ENST00000433981.2_Missense_Mutation_p.P235L|CTD-3148I10.9_ENST00000599536.1_Intron	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	400							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TTGCAGGTGCCGTGGCCTGTG	0.711000													6	33					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100897230	100897230	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:100897230C>T	ENST00000188403.7	+	1	93	c.65C>T	c.(64-66)cCg>cTg	p.P22L	NR1H4_ENST00000551379.1_Missense_Mutation_p.P22L|NR1H4_ENST00000546380.1_Intron|NR1H4_ENST00000392986.3_Intron|NR1H4_ENST00000548884.1_Intron|NR1H4_ENST00000549996.1_Intron	NM_001206992.1|NM_001206993.1	NP_001193921.1|NP_001193922.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	22					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						AGCTGTACGCCGTCAGGATTT	0.448000													3	27					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187466749	187466749	+	Splice_Site	SNP	C	C	T	rs142312022	byFrequency	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:187466749C>T	ENST00000261023.3	+	2	461	c.185_splice	c.e2-1	p.R63_splice	ITGAV_ENST00000433736.2_Splice_Site_p.R17_splice|ITGAV_ENST00000374907.3_Splice_Site_p.R63_splice	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	63					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GTATTTTAGCCGGATGTTTCT	0.443000													9	82					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691558	109691558	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:109691558C>T	ENST00000277225.5	+	3	5654	c.5365C>T	c.(5365-5367)Cgc>Tgc	p.R1789C	ZNF462_ENST00000457913.1_Missense_Mutation_p.R1789C|ZNF462_ENST00000441147.2_Missense_Mutation_p.R634C			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1789					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TTACATGAAACGCCACCCAGG	0.562000													24	131					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52535585	52535585	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:52535585C>G	ENST00000216286.5	-	1	127	c.128G>C	c.(127-129)tGg>tCg	p.W43S	NID2_ENST00000541773.1_Intron	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	43						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CTGGTCCCCCCACGACTCCCC	0.632000													12	67					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553338	140553338	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140553338G>A	ENST00000231137.3	+	1	1096	c.922G>A	c.(922-924)Gac>Aac	p.D308N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		308	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCGCAATTGGACTATGAGGC	0.403000													19	93					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186570747	186570747	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:186570747G>A	ENST00000431808.1	-	10	1006	c.443C>T	c.(442-444)cCt>cTt	p.P148L	SORBS2_ENST00000449407.2_Missense_Mutation_p.P219L|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000437304.2_Missense_Mutation_p.P327L|SORBS2_ENST00000355634.5_Missense_Mutation_p.P248L|SORBS2_ENST00000393528.3_Missense_Mutation_p.P194L|SORBS2_ENST00000319471.9_Missense_Mutation_p.P234L|SORBS2_ENST00000284776.7_Missense_Mutation_p.P148L|SORBS2_ENST00000448662.2_Missense_Mutation_p.P217L|SORBS2_ENST00000418609.1_Missense_Mutation_p.P52L			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	148						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTTGGAAAGAGGTCTGTAGGT	0.522000													15	70					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176853596	176853596	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:176853596G>T	ENST00000367654.2	-	19	3142	c.3129C>A	c.(3127-3129)agC>agA	p.S1043R	ASTN1_ENST00000361833.2_Missense_Mutation_p.S1035R|ASTN1_ENST00000424564.2_Missense_Mutation_p.S1035R|ASTN1_ENST00000367657.3_Missense_Mutation_p.S1035R			O14525	ASTN1_HUMAN	astrotactin 1	1043	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CAAGAGTGCTGCTGGGCTCGT	0.537000													51	67					7.71302e-15	1.00164e-14	1	1	0
CCDC147	159686	broad.mit.edu	37	10	106130709	106130709	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:106130709C>G	ENST00000369704.3	+	7	1121	c.987C>G	c.(985-987)atC>atG	p.I329M	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	329										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TCAACAAAATCAGAGAACAAA	0.383000													7	39					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53667757	53667757	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:53667757G>C	ENST00000600412.1	-	2	1906	c.1791C>G	c.(1789-1791)gtC>gtG	p.V597V	ZNF665_ENST00000396424.3_Silent_p.V662V			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TTTGAGTAAAGACCTTGCCAC	0.453000													6	35					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33936610	33936610	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:33936610C>A	ENST00000389232.4	+	28	3725	c.3655C>A	c.(3655-3657)Caa>Aaa	p.Q1219K	RYR3_ENST00000415757.3_Missense_Mutation_p.Q1219K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1219	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGCGGTCTCCAAGAGGGCTT	0.517000													3	23					0.004672	0.0048704	1	1	0
HRNR	388697	broad.mit.edu	37	1	152191804	152191804	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:152191804T>A	ENST00000368801.2	-	3	2376	c.2301A>T	c.(2299-2301)cgA>cgT	p.R767R	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	767					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCCTTGTCGGCCGTGGC	0.582000													26	204					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64360916	64360916	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:64360916G>C	ENST00000377574.1	+	3	1293	c.546G>C	c.(544-546)caG>caC	p.Q182H	SLC22A12_ENST00000377567.2_Intron|SLC22A12_ENST00000377572.1_Intron|SLC22A12_ENST00000473690.1_Intron|SLC22A12_ENST00000336464.7_Missense_Mutation_p.Q182H	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	182					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						GCTACCTTCAGATGGCTGTGA	0.632000													21	201					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69350199	69350199	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:69350199A>G	ENST00000303714.4	+	11	1175	c.853A>G	c.(853-855)Atc>Gtc	p.I285V	ANTXR1_ENST00000409829.3_Missense_Mutation_p.I285V|ANTXR1_ENST00000409349.3_Missense_Mutation_p.I285V	NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	285					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCCAGCGCCTATCTTAAAAGA	0.443000									Familial Infantile Hemangioma				34	74					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677167	100677167	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:100677167A>G	ENST00000306151.4	+	3	2534	c.2470A>G	c.(2470-2472)Agc>Ggc	p.S824G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	824	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTGAGGCTAGCACCCTTTC	0.488000													80	640					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72345425	72345425	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:72345425G>T	ENST00000389916.4	+	10	1288	c.1150G>T	c.(1150-1152)Gag>Tag	p.E384*		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	384					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CAAGATTGATGAGCAGACTGG	0.647000													14	67					6.72482e-11	8.21443e-11	1	1	0
TSC1	7248	broad.mit.edu	37	9	135786048	135786048	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:135786048T>A	ENST00000298552.3	-	12	1394	c.1173A>T	c.(1171-1173)ccA>ccT	p.P391P	TSC1_ENST00000545250.1_Silent_p.P340P|TSC1_ENST00000440111.2_Silent_p.P391P	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	391					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GAGAGGTTGCTGGGGTTCCCA	0.517000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				100	250					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585729	33585729	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:33585729G>T	ENST00000404816.2	+	27	4419	c.4066G>T	c.(4066-4068)Gcc>Tcc	p.A1356S	LTBP1_ENST00000418533.2_Missense_Mutation_p.A988S|LTBP1_ENST00000354476.3_Missense_Mutation_p.A1357S|LTBP1_ENST00000404525.1_Missense_Mutation_p.A977S|LTBP1_ENST00000390003.4_Missense_Mutation_p.A1031S|LTBP1_ENST00000402934.1_Missense_Mutation_p.A975S|LTBP1_ENST00000407925.1_Missense_Mutation_p.A1030S|LTBP1_ENST00000272273.5_Missense_Mutation_p.A254S			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1356	TB 3.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCTCAATGACGCCAGTCTCTG	0.423000													30	60					3.99451e-17	5.39933e-17	1	1	0
HELB	92797	broad.mit.edu	37	12	66703495	66703495	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:66703495A>T	ENST00000247815.4	+	4	846	c.787A>T	c.(787-789)Aga>Tga	p.R263*		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	263					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GATAACCTACAGAGAGTGGAA	0.338000													28	113					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626762	49626762	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:49626762C>T	ENST00000371571.4	-	2	399	c.114G>A	c.(112-114)gcG>gcA	p.A38A	KCNG1_ENST00000396017.3_Silent_p.A38A	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	38						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGCGGTAGAACGCGCCCTTGA	0.697000													15	37					0	0	1	0	0
F7	2155	broad.mit.edu	37	13	113773177	113773177	+	Missense_Mutation	SNP	C	C	T	rs121964930		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:113773177C>T	ENST00000375581.3	+	9	1291	c.1256C>T	c.(1255-1257)aCg>aTg	p.T419M	F7_ENST00000346342.3_Missense_Mutation_p.T397M|F7_ENST00000541084.1_Missense_Mutation_p.T350M	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	419	Peptidase S1.		T -> M (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	TGGTACCTGACGGGCATCGTC	0.632000													10	37					0	0	1	0	0
IL20	50604	broad.mit.edu	37	1	207039227	207039227	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:207039227T>C	ENST00000367098.1	+	2	393	c.30T>C	c.(28-30)ctT>ctC	p.L10L	IL20_ENST00000391930.2_Silent_p.L10L|IL20_ENST00000367096.3_Silent_p.L10L			Q9NYY1	IL20_HUMAN	interleukin 20	10					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)|urinary_tract(1)	9	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		CCTTCAGCCTTCTCTCTGCTG	0.468000													40	95					0	0	1	0	0
SF3B2	10992	broad.mit.edu	37	11	65822628	65822628	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:65822628G>A	ENST00000528302.1	+	4	394	c.340G>A	c.(340-342)Ggc>Agc	p.G114S	SF3B2_ENST00000322535.6_Missense_Mutation_p.G114S			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	114					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						ACCTCCACCAGGCCTTGGCCT	0.632000													41	75					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	883121	883121	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:883121G>A	ENST00000456758.2	+	8	796	c.796G>A	c.(796-798)Gtg>Atg	p.V266M	SUN1_ENST00000405266.1_Missense_Mutation_p.V208M|SUN1_ENST00000403868.1_Missense_Mutation_p.V208M|SUN1_ENST00000401592.1_Missense_Mutation_p.V208M|SUN1_ENST00000425407.2_Missense_Mutation_p.V158M|SUN1_ENST00000389574.3_Missense_Mutation_p.V158M|SUN1_ENST00000457378.2_Missense_Mutation_p.V229M|SUN1_ENST00000452783.2_Intron			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	208	EMD-binding.|SYNE2-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCCGGGCCCGTGTCGAGAGT	0.542000													39	454					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112766012	112766012	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:112766012C>A	ENST00000295408.4	+	14	2177	c.1920C>A	c.(1918-1920)tgC>tgA	p.C640*	MERTK_ENST00000409780.1_Nonsense_Mutation_p.C464*|MERTK_ENST00000421804.2_Nonsense_Mutation_p.C640*			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	640	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						AGGCAGCGTGCATGAAAGACT	0.473000													23	87					8.16721e-17	1.09423e-16	1	1	0
IGHV4-4	28401	broad.mit.edu	37	14	106478460	106478460	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:106478460C>T	ENST00000390596.2	-	0	110																											AGGCACCTCCCATATCCCCAT	0.592000													3	31					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648758	130648758	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:130648758G>T	ENST00000229030.4	+	1	1755	c.1271G>T	c.(1270-1272)cGg>cTg	p.R424L	FZD10_ENST00000539839.1_Silent_p.P391P			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	424					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TTCCACATCCGGAGGGTGATG	0.622000													43	69					2.24722e-20	3.16106e-20	1	1	0
SLC14A2	8170	broad.mit.edu	37	18	43217147	43217147	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:43217147G>T	ENST00000255226.6	+	6	1659	c.843_splice	c.e6+1	p.L281_splice	SLC14A2_ENST00000586448.1_Splice_Site_p.L281_splice	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	281						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AAATGCCCCTGGTAAGTTACC	0.507000													17	56					0.000132079	0.000144	1	1	0
ARHGEF37	389337	broad.mit.edu	37	5	148996182	148996182	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:148996182A>T	ENST00000333677.6	+	5	674	c.511A>T	c.(511-513)Agg>Tgg	p.R171W		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	171	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						TCCTCTGCAGAGGATCACCAG	0.557000													24	46					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7682812	7682812	+	Silent	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:7682812A>T	ENST00000256861.6	-	4	384	c.306T>A	c.(304-306)atT>atA	p.I102I	ITIH5_ENST00000397146.2_Silent_p.I102I|ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397145.2_Silent_p.I102I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	102	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CCTTGTCTCCAATAAGCCTGA	0.393000													16	156					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370849	240370849	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:240370849C>A	ENST00000319653.9	+	5	2967	c.2737C>A	c.(2737-2739)Cct>Act	p.P913T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	913	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCCCCTCCCCCTCCTCTTCC	0.657000													48	346					4.32865e-36	6.56196e-36	1	1	0
GAS2L2	246176	broad.mit.edu	37	17	34073306	34073306	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:34073306C>T	ENST00000254466.6	-	6	1237	c.1210G>A	c.(1210-1212)Gag>Aag	p.E404K	GAS2L2_ENST00000587565.1_Missense_Mutation_p.E388K	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	404					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATCTCTCCTCCCTCTTTCCT	0.607000													30	213					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667544	72667544	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:72667544G>A	ENST00000373514.2	+	1	455	c.455G>A	c.(454-456)aGc>aAc	p.S152N		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					CCCAGCAGGAGCCGCCACAGC	0.642000													21	21					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400747	89400747	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:89400747C>T	ENST00000439576.2	+	12	5305	c.4931C>T	c.(4930-4932)tCt>tTt	p.S1644F	ACAN_ENST00000559004.1_Missense_Mutation_p.S1644F|ACAN_ENST00000352105.7_Missense_Mutation_p.S1644F|ACAN_ENST00000561243.1_Missense_Mutation_p.S1644F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1644					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGCCCACCCTCTGGCCTGCCT	0.517000													29	214					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216219863	216219863	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:216219863T>G	ENST00000366943.2	-	32	6621	c.6235A>C	c.(6235-6237)Aaa>Caa	p.K2079Q	USH2A_ENST00000307340.3_Missense_Mutation_p.K2079Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2079	Fibronectin type-III 7.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.K2079E(2)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTGCCTTTTTGGGTGGGTTC	0.453000										HNSCC(13;0.011)			17	106					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186008858	186008858	+	Splice_Site	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:186008858A>T	ENST00000271588.4	+	39	6257		c.e39-1		HMCN1_ENST00000367492.2_Splice_Site	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1						response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTTTTTTTCAGTGGCCCCAT	0.393000													41	147					0	0	1	0	0
HTN3	3347	broad.mit.edu	37	4	70896505	70896505	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:70896505G>T	ENST00000530128.1	+	2	123	c.48G>T	c.(46-48)atG>atT	p.M16I	HTN3_ENST00000381057.3_Missense_Mutation_p.M16I|HTN3_ENST00000526767.1_Missense_Mutation_p.M16I			P15516	HIS3_HUMAN	histatin 3	16					biomineral tissue development|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	metal ion binding|protein binding			breast(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	8						TGCTTTCCATGACTGTAAGTA	0.333000													9	18					0.000673444	0.000717774	1	1	0
CLIC6	54102	broad.mit.edu	37	21	36079667	36079667	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:36079667G>T	ENST00000360731.3	+	3	1518	c.1518G>T	c.(1516-1518)gtG>gtT	p.V506V	CLIC6_ENST00000349499.2_Silent_p.V488V			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	506						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						TATTTAATGTGACCACAGTGG	0.448000													6	29					2.7689e-08	3.20233e-08	1	1	0
CAPN2	824	broad.mit.edu	37	1	223940636	223940636	+	Silent	SNP	G	G	T	rs145344369		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:223940636G>T	ENST00000295006.5	+	9	1422	c.1113G>T	c.(1111-1113)gcG>gcT	p.A371A	CAPN2_ENST00000433674.2_Silent_p.A293A	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	371	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GCTCCACCGCGGGAGGTTGCA	0.562000													19	176					1.10513e-12	1.39009e-12	1	1	0
CYP21A1P	1590	broad.mit.edu	37	6	31975626	31975626	+	RNA	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:31975626G>T	ENST00000342991.6	+	0	1549					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										CGGCCCAGCAGGTGACTCCCG	0.667000													7	24					0.0293803	0.029931	1	1	0
ERAP2	64167	broad.mit.edu	37	5	96215603	96215603	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:96215603G>A	ENST00000437043.3	+	2	925	c.214G>A	c.(214-216)Gtg>Atg	p.V72M	ERAP2_ENST00000510309.1_Missense_Mutation_p.V72M|CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Missense_Mutation_p.V72M	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	72					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GCTCCCCAGTGTGGTCATTCC	0.502000													10	43					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773810	140773810	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140773810A>T	ENST00000398604.2	+	1	1430	c.1430A>T	c.(1429-1431)cAc>cTc	p.H477L	PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGACTGCACACGACCCCGAC	0.547000													12	28					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681272	100681272	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:100681272T>G	ENST00000306151.4	+	3	6639	c.6575T>G	c.(6574-6576)gTg>gGg	p.V2192G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2192	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACACCTGTGACCAATTCT	0.483000													317	506					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79387517	79387517	+	Silent	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:79387517C>G	ENST00000264895.6	+	50	7625	c.7185C>G	c.(7183-7185)ctC>ctG	p.L2395L		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2394					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GTAACTCCCTCAAGGACCGGT	0.522000													19	61					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	37					0	0	1	0	0
GPATCH4	54865	broad.mit.edu	37	1	156565024	156565024	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156565024C>G	ENST00000368232.4	-	8	1226	c.1094G>C	c.(1093-1095)aGa>aCa	p.R365T	GPATCH4_ENST00000438976.2_Missense_Mutation_p.R370T	NM_015590.3|NM_182679.2	NP_056405.2|NP_872620.1	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4	0						intracellular	nucleic acid binding			autonomic_ganglia(1)|breast(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(3)|stomach(1)	17	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCTCTGCTCTCTGCTTCCCTG	0.493000													39	295					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923925	43923925	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:43923925C>T	ENST00000329196.5	+	1	1670	c.1653C>T	c.(1651-1653)ggC>ggT	p.G551G	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	551						integral to membrane	aspartic-type endopeptidase activity										AGCAGGAGGGCGCAGCAGATG	0.612000													22	90					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399083	79399083	+	Missense_Mutation	SNP	C	C	A	rs78484528		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:79399083C>A	ENST00000264895.6	+	55	8406	c.7966C>A	c.(7966-7968)Ctg>Atg	p.L2656M		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2651					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AGCTTATGCCCTGTTAGGGGA	0.483000													3	29					1	1	1	1	0
TTN	7273	broad.mit.edu	37	2	179584160	179584160	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:179584160G>A	ENST00000589042.1	-	83	24181	c.23957C>T	c.(23956-23958)tCc>tTc	p.S7986F	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S7669F|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S6742F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7669	Ig-like 62.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGGATGAAGGAAGGAGGCAC	0.493000													38	55					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761058	92761058	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:92761058T>C	ENST00000318238.4	-	5	5443	c.4227A>G	c.(4225-4227)caA>caG	p.Q1409Q	SAMD9L_ENST00000411955.1_Silent_p.Q1409Q|SAMD9L_ENST00000437805.1_Silent_p.Q1409Q	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1409										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCTCTCGGAGTTGTTTTTTTA	0.403000													84	113					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042710	75042710	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:75042710G>A	ENST00000343932.4	+	2	694	c.631G>A	c.(631-633)Gag>Aag	p.E211K		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	211					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GCACTTCCCTGAGAGTAGCGA	0.577000													45	290					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080655	152080655	+	Missense_Mutation	SNP	C	C	G	rs71585886		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:152080655C>G	ENST00000368804.1	-	2	5037	c.5038G>C	c.(5038-5040)Gag>Cag	p.E1680Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1680	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGTTCCTCCCCTTCCTGG	0.602000													52	210					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789568	89789568	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:89789568G>T	ENST00000289816.5	+	3	620	c.308G>T	c.(307-309)gGg>gTg	p.G103V	ZNF276_ENST00000446326.2_5'UTR|ZNF276_ENST00000568064.1_Missense_Mutation_p.G103V|ZNF276_ENST00000443381.2_Missense_Mutation_p.G178V	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	178	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CCCCCAACAGGGGCAGAGGAG	0.647000													10	108					2.27111e-07	2.57957e-07	1	1	0
MAP1B	4131	broad.mit.edu	37	5	71492093	71492093	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:71492093C>A	ENST00000296755.7	+	5	3209	c.2911C>A	c.(2911-2913)Ccc>Acc	p.P971T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	971						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CAAGCACAGCCCCACTGAGGA	0.562000													13	50					4.93089e-13	6.24361e-13	1	1	0
MSLNL	401827	broad.mit.edu	37	16	830602	830602	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:830602C>T	ENST00000293892.3	-	3	398	c.399G>A	c.(397-399)gcG>gcA	p.A133A	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CGTGCAGGCACGCATGTGTAG	0.557000													48	237					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129807520	129807520	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:129807520G>A	ENST00000358825.5	-	8	1243	c.1012C>T	c.(1012-1014)Cat>Tat	p.H338Y	PRDM10_ENST00000423662.2_Missense_Mutation_p.H252Y|PRDM10_ENST00000526082.1_Missense_Mutation_p.H252Y|PRDM10_ENST00000304538.6_Missense_Mutation_p.H252Y|PRDM10_ENST00000360871.3_Missense_Mutation_p.H338Y|PRDM10_ENST00000528746.1_Missense_Mutation_p.H312Y	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GAAATGTCATGAATTTTCTGG	0.373000													18	66					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51855296	51855296	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:51855296C>A	ENST00000322475.8	+	4	1680	c.1545C>A	c.(1543-1545)tgC>tgA	p.C515*	FAM124A_ENST00000280057.6_Nonsense_Mutation_p.C551*	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	515								p.C551C(2)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		AGCTCCCATGCGATACCCCCA	0.597000													22	138					3.01185e-09	3.50998e-09	1	1	0
TMPO	7112	broad.mit.edu	37	12	98927619	98927619	+	Silent	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:98927619A>T	ENST00000266732.4	+	4	1822	c.1584A>T	c.(1582-1584)acA>acT	p.T528T	TMPO_ENST00000261210.5_Intron|TMPO_ENST00000343315.5_Intron|TMPO_ENST00000556029.1_Intron|TMPO_ENST00000393053.2_Intron	NM_003276.2	NP_003267.1	P42167	LAP2B_HUMAN	thymopoietin	0						integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGGAGGCAACACAGATATTAT	0.418000													15	53					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32222290	32222290	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:32222290C>A	ENST00000373658.3	-	4	489	c.148G>T	c.(148-150)Ggg>Tgg	p.G50W	BAI2_ENST00000398542.1_Missense_Mutation_p.G38W|BAI2_ENST00000373655.2_Missense_Mutation_p.G50W|BAI2_ENST00000527361.1_Missense_Mutation_p.G50W|BAI2_ENST00000398538.1_Missense_Mutation_p.G38W|BAI2_ENST00000398547.1_Missense_Mutation_p.G38W|BAI2_ENST00000257070.4_Missense_Mutation_p.G50W|BAI2_ENST00000398556.3_Missense_Mutation_p.G53W	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	50					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GAGAAGGCCCCGTAGAGCACA	0.652000													4	20					0.0215528	0.0220156	1	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54925582	54925582	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:54925582G>T	ENST00000293373.6	+	25	2833	c.2754G>T	c.(2752-2754)agG>agT	p.R918S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R868S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	918					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCAGTTTCAGGGCCATGGCCC	0.488000													39	57					3.7052e-28	5.50715e-28	1	1	0
OSBPL2	9885	broad.mit.edu	37	20	60861642	60861642	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:60861642G>A	ENST00000313733.3	+	11	1202	c.1000G>A	c.(1000-1002)Gaa>Aaa	p.E334K	OSBPL2_ENST00000439951.2_Missense_Mutation_p.E242K|OSBPL2_ENST00000358053.2_Missense_Mutation_p.E322K	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	334					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTTTCAGGATGAAGACTCCGG	0.617000													23	254					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19382003	19382003	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:19382003G>A	ENST00000263208.5	-	8	940	c.684C>T	c.(682-684)ctC>ctT	p.L228L	HIRA_ENST00000546308.1_Silent_p.L184L|HIRA_ENST00000340170.4_Silent_p.L228L|HIRA_ENST00000541063.1_Silent_p.L184L	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	228					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					GTGACCAGCTGAGCCGCAACA	0.547000													6	163					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128351	3128351	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:3128351T>A	ENST00000380266.3	-	2	1687	c.1366A>T	c.(1366-1368)Agt>Tgt	p.S456C	UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	456					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						TGAATCTCACTTATCAGGCTG	0.458000													48	88					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769975	31769975	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:31769975C>T	ENST00000240587.4	-	2	1051	c.724G>A	c.(724-726)Gac>Aac	p.D242N		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	242					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCATGGTTGTCGTCGCGGTAA	0.592000													88	350					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176165	57176165	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:57176165C>A	ENST00000537055.2	-	2	633	c.402G>T	c.(400-402)ggG>ggT	p.G134G		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						ATGGCTTCTCCCCGGTGTGGA	0.627000													23	161					1.75199e-13	2.22953e-13	1	1	0
FZD6	8323	broad.mit.edu	37	8	104340590	104340590	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:104340590G>C	ENST00000358755.4	+	5	1804	c.1487G>C	c.(1486-1488)aGc>aCc	p.S496T	FZD6_ENST00000540287.1_Missense_Mutation_p.S191T|FZD6_ENST00000523739.1_Missense_Mutation_p.S464T|FZD6_ENST00000522566.1_Missense_Mutation_p.S496T	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	496					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			TGGGTTGGAAGCAAAAAGACA	0.353000													9	59					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51129258	51129258	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:51129258C>T	ENST00000338916.4	-	5	1931	c.1298G>A	c.(1297-1299)gGg>gAg	p.G433E	SYT3_ENST00000600079.1_Missense_Mutation_p.G433E|SYT3_ENST00000593901.1_Missense_Mutation_p.G433E|SYT3_ENST00000544769.1_Missense_Mutation_p.G433E	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	433	C2 2.					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GTTGAGCTCCCCAAGATCTGC	0.562000													8	29					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703149	74703149	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:74703149T>A	ENST00000261918.4	-	14	2365	c.1817A>T	c.(1816-1818)cAg>cTg	p.Q606L	SEMA7A_ENST00000543145.2_Missense_Mutation_p.Q592L|SEMA7A_ENST00000542748.1_Missense_Mutation_p.Q441L	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	606	Ig-like C2-type.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						GCCGTACTGCTGCGCCGTGAG	0.637000													27	46					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220337737	220337737	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:220337737A>G	ENST00000312358.7	+	16	4198	c.4066A>G	c.(4066-4068)Atc>Gtc	p.I1356V	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1356	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGTCCAGCACATCTTCCGGGT	0.672000													13	64					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819247	50819247	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:50819247C>A	ENST00000374115.3	+	1	901	c.461C>A	c.(460-462)cCg>cAg	p.P154Q	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	154					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TACGACGTGCCGCTGCTGATC	0.637000													17	179					1.33834e-09	1.58148e-09	1	1	0
MYH7	4625	broad.mit.edu	37	14	23899792	23899792	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:23899792C>T	ENST00000355349.3	-	11	1138	c.976G>A	c.(976-978)Gct>Act	p.A326T		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	326	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGCTCCTCAGCGTCATCAATG	0.542000													14	23					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129049331	129049331	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:129049331G>A	ENST00000325006.3	+	11	1364	c.1310G>A	c.(1309-1311)cGa>cAa	p.R437Q	AHCYL2_ENST00000474594.1_Missense_Mutation_p.R334Q|AHCYL2_ENST00000531335.2_Missense_Mutation_p.R356Q|AHCYL2_ENST00000446212.1_Missense_Mutation_p.R335Q|AHCYL2_ENST00000490911.1_Missense_Mutation_p.R334Q|AHCYL2_ENST00000446544.2_Missense_Mutation_p.R436Q	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	437					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GATGGATTTCGACTGGTGAAA	0.393000													17	107					0	0	1	0	0
SLC2A7	155184	broad.mit.edu	37	1	9075181	9075181	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:9075181C>A	ENST00000400906.1	-	6	709	c.710G>T	c.(709-711)cGa>cTa	p.R237L		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	237						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CATACCTTGTCGCGCTGTGGC	0.662000													15	21					1.55795e-14	2.0129e-14	1	1	0
MATN1	4146	broad.mit.edu	37	1	31188925	31188925	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:31188925G>C	ENST00000373765.4	-	5	1073	c.1038C>G	c.(1036-1038)tcC>tcG	p.S346S	MATN1_ENST00000477320.1_5'UTR	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	346	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCATGTAGGACATATTCC	0.587000													37	159					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77243905	77243905	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:77243905G>A	ENST00000341514.6	+	3	443	c.288G>A	c.(286-288)ctG>ctA	p.L96L	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Silent_p.L96L	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	96					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						CGGCGTCACTGACTTTGCCAT	0.433000													111	249					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47408889	47408889	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:47408889C>A	ENST00000295454.3	+	8	1318	c.1026C>A	c.(1024-1026)agC>agA	p.S342R	GABRB1_ENST00000538619.1_Missense_Mutation_p.S272R	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	342					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGGGAGCTAGCAAACAAGACC	0.378000													7	58					0.00198382	0.00209098	1	1	0
LRMP	4033	broad.mit.edu	37	12	25232661	25232661	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:25232661G>T	ENST00000354454.3	+	8	1037	c.208G>T	c.(208-210)Gat>Tat	p.D70Y	LRMP_ENST00000547044.1_Missense_Mutation_p.D70Y|LRMP_ENST00000548766.1_Missense_Mutation_p.D70Y	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	126					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					GAAAGAGGAGGATACAAGATC	0.408000													10	88					1.61879e-10	1.94921e-10	1	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28315846	28315846	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:28315846G>T	ENST00000284987.5	-	3	1379	c.1258C>A	c.(1258-1260)Cat>Aat	p.H420N		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	420	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GAATCGTCATGGGAGAGGCCA	0.428000													7	32					0.000673444	0.000717774	1	1	0
DAZAP1	26528	broad.mit.edu	37	19	1433757	1433757	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:1433757A>G	ENST00000336761.6	+	12	1273	c.1068A>G	c.(1066-1068)ccA>ccG	p.P356P	DAZAP1_ENST00000233078.4_Intron	NM_170711.1	NP_733829.1	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	248	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTATTCTCCAGCCCCGCCGG	0.637000													16	99					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106607	168106607	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:168106607A>G	ENST00000409195.1	+	9	8794	c.8705A>G	c.(8704-8706)aAg>aGg	p.K2902R	XIRP2_ENST00000295237.9_Missense_Mutation_p.K2902R|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.K2680R|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2727					actin cytoskeleton organization	cell junction	actin binding	p.K2902R(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTCGAAGTCAAGGGCATACAA	0.378000													10	49					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74715219	74715219	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:74715219A>G	ENST00000370895.1	+	5	564	c.529A>G	c.(529-531)Att>Gtt	p.I177V	TNNI3K_ENST00000370891.2_Missense_Mutation_p.I177V|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.I177V|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.I177V|TNNI3K_ENST00000326637.3_Missense_Mutation_p.I76V			Q59H18	TNI3K_HUMAN		76						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TTTATGTTGCATTTGTGGAGG	0.353000													9	43					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228492215	228492215	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:228492215G>A	ENST00000570156.2	+	53	14288	c.14214G>A	c.(14212-14214)gaG>gaA	p.E4738E	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000366707.4_Silent_p.E1428E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3781					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ATGCCGGGGAGTACTCGTGCG	0.587000													28	219					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638531	113638531	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:113638531A>G	ENST00000361127.4	+	7	1037	c.839A>G	c.(838-840)aAg>aGg	p.K280R		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	280						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CGAGTAAACAAGGGGTGGTTG	0.418000													17	62					0	0	1	0	0
PVRL1	5818	broad.mit.edu	37	11	119535671	119535671	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:119535671C>A	ENST00000264025.3	-	6	1870	c.1340G>T	c.(1339-1341)gGa>gTa	p.G447V	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	447	Poly-Gly.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CTCGCCCCCTCCACCGCcctc	0.672000													14	13					2.32078e-09	2.72549e-09	1	1	0
PRKCQ	5588	broad.mit.edu	37	10	6549436	6549436	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:6549436C>A	ENST00000263125.5	-	4	440	c.341G>T	c.(340-342)cGa>cTa	p.R114L	PRKCQ_ENST00000397176.2_Missense_Mutation_p.R114L|PRKCQ_ENST00000539722.1_Intron	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	114	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						CATTAGCATTCGGCCTTGAGG	0.468000													176	234					4.24426e-87	6.60508e-87	1	1	0
SERPINI1	5274	broad.mit.edu	37	3	167507043	167507043	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:167507043G>A	ENST00000295777.5	+	2	558	c.127G>A	c.(127-129)Gat>Aat	p.D43N	SERPINI1_ENST00000446050.2_Missense_Mutation_p.D43N	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	43					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						CACTGGTGAAGATGAAAATAT	0.458000													13	122					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117959242	117959242	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:117959242G>A	ENST00000310164.2	+	4	542	c.35G>A	c.(34-36)cGg>cAg	p.R12Q		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						GGTAACAGCCGGCGGCTGAAT	0.517000													24	47					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112147407	112147407	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:112147407G>T	ENST00000455480.2	+	5	786	c.609G>T	c.(607-609)ctG>ctT	p.L203L	ACAD10_ENST00000313698.4_Silent_p.L203L|ACAD10_ENST00000392636.2_5'UTR|ACAD10_ENST00000549590.1_Silent_p.L203L|ACAD10_ENST00000413681.3_3'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	203							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						AGCTCGGCCTGCAGCCCTCTG	0.468000													16	45					2.94398e-08	3.38937e-08	1	1	0
EEFSEC	60678	broad.mit.edu	37	3	128127045	128127045	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:128127045C>T	ENST00000254730.6	+	7	1788	c.1734C>T	c.(1732-1734)agC>agT	p.S578S	EEFSEC_ENST00000483457.1_3'UTR	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	578						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						TGGTGCTCAGCCTGACTTTCA	0.667000													7	103					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40408562	40408562	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:40408562G>T	ENST00000221347.6	-	8	4284	c.4277C>A	c.(4276-4278)tCt>tAt	p.S1426Y		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1426	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGCAGGGAGAGTCGGGCAC	0.627000													23	77					3.65163e-15	4.76653e-15	1	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77325175	77325175	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:77325175C>T	ENST00000282849.5	-	21	3808	c.3390G>A	c.(3388-3390)ttG>ttA	p.L1130L		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1130	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GCTGCCACGGCAATGAATACC	0.483000													35	74					0	0	1	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013306	149013306	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:149013306C>A	ENST00000535454.1	+	4	809	c.260C>A	c.(259-261)tCc>tAc	p.S87Y	MAGEA8_ENST00000286482.1_Missense_Mutation_p.S87Y|MAGEA8_ENST00000493910.1_3'UTR|MAGEA8_ENST00000542674.1_Missense_Mutation_p.S87Y	NM_001166400.1	NP_001159872.1	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	87										NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)					GATGAGGGTTCCAGCAGCAAT	0.582000													29	69					2.68265e-12	3.33578e-12	1	1	0
SPAG6	9576	broad.mit.edu	37	10	22678130	22678130	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:22678130G>T	ENST00000376603.2	+	7	1264	c.1122G>T	c.(1120-1122)gtG>gtT	p.V374V	SPAG6_ENST00000538630.1_Silent_p.V273V|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Silent_p.V298V|SPAG6_ENST00000376601.1_Intron|SPAG6_ENST00000313311.6_Silent_p.V298V			O75602	SPAG6_HUMAN	sperm associated antigen 6	298					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TTGCTGCCGTGATTGACTGCA	0.493000													44	56					8.72198e-27	1.28882e-26	1	1	0
TREM2	54209	broad.mit.edu	37	6	41126668	41126668	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:41126668G>T	ENST00000373113.3	-	4	712	c.619C>A	c.(619-621)Cca>Aca	p.P207T	TREM2_ENST00000373122.4_Missense_Mutation_p.S220Y|TREM2_ENST00000338469.3_Intron	NM_018965.2	NP_061838.1	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	207					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCACTGGGTGGATGTGTCCCT	0.592000													53	128					1.27102e-15	1.66479e-15	1	1	0
OVCH1	341350	broad.mit.edu	37	12	29640664	29640664	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:29640664G>A	ENST00000318184.5	-	7	853	c.854C>T	c.(853-855)tCt>tTt	p.S285F		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	285	CUB 1.|Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					catcaactcagacactttgga	0.443000													10	15					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127434403	127434403	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:127434403G>T	ENST00000337623.3	+	18	2721	c.2616G>T	c.(2614-2616)acG>acT	p.T872T	RP11-383C5.7_ENST00000449436.1_RNA|C10orf137_ENST00000356792.4_Silent_p.T906T|RP11-383C5.7_ENST00000594025.1_RNA|RP11-383C5.7_ENST00000593871.1_RNA|RP11-383C5.7_ENST00000600784.1_RNA|RP11-383C5.7_ENST00000602030.1_RNA	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	906					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding	p.T872T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TATGTAACACGGGAAGGCTCA	0.418000													9	136					0.000673444	0.000717774	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103379246	103379246	+	Splice_Site	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:103379246C>A	ENST00000358392.2	-	53	4332	c.4014_splice	c.e53-1	p.G1339_splice	COL11A1_ENST00000353414.4_Splice_Site_p.G1288_splice|COL11A1_ENST00000370096.3_Splice_Site_p.G1327_splice|COL11A1_ENST00000512756.1_Splice_Site_p.G1211_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1327	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCATCTTGACCCTATAAGAGG	0.353000													23	134					1.55811e-20	2.19986e-20	1	1	0
C3orf14	57415	broad.mit.edu	37	3	62317067	62317067	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:62317067C>G	ENST00000494481.1	+	5	559	c.245C>G	c.(244-246)tCt>tGt	p.S82C	C3orf14_ENST00000542214.1_Missense_Mutation_p.S82C|C3orf14_ENST00000462069.1_Missense_Mutation_p.S82C|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000490916.1_RNA|C3orf14_ENST00000232519.5_Missense_Mutation_p.S82C			Q9HBI5	CC014_HUMAN	chromosome 3 open reading frame 14	82										central_nervous_system(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00023)|KIRC - Kidney renal clear cell carcinoma(15;0.00877)|Kidney(15;0.0101)		GAGGTGGTTTCTCTTGAGGTG	0.393000													37	73					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152954856	152954856	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:152954856G>A	ENST00000539935.1	-	2	202	c.135C>T	c.(133-135)ttC>ttT	p.F45F	CACNB4_ENST00000427385.1_Silent_p.F27F|CACNB4_ENST00000201943.5_Silent_p.F45F|AC079790.2_ENST00000420365.1_RNA	NM_000726.3|NM_001145798.1	NP_000717.2|NP_001139270.1	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	45					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GTCTGAGGATGAAGCTGGTCG	0.672000													26	139					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241700092	241700092	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:241700092C>G	ENST00000498729.2	-	25	2680	c.2434G>C	c.(2434-2436)Gag>Cag	p.E812Q	KIF1A_ENST00000320389.7_Missense_Mutation_p.E803Q	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	803					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTGAGCTTCTCCAGCGTCCAG	0.672000													5	11					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060185	35060185	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:35060185C>A	ENST00000373913.3	+	3	545	c.65C>A	c.(64-66)cCc>cAc	p.P22H	DLGAP4_ENST00000373907.2_Missense_Mutation_p.P22H|DLGAP4_ENST00000339266.5_Missense_Mutation_p.P22H|DLGAP4_ENST00000401952.2_Missense_Mutation_p.P22H			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	22					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCCACGAGCCCCTGTTTGCA	0.701000													25	119					2.68265e-12	3.33578e-12	1	1	0
ZNF468	90333	broad.mit.edu	37	19	53344659	53344659	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:53344659C>T	ENST00000595646.1	-	4	1008	c.888G>A	c.(886-888)gaG>gaA	p.E296E	ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Silent_p.E243E|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Silent_p.E243E			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		CATAAGGTTTCTCTCCAGTAT	0.393000													39	101					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79614075	79614075	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:79614075C>A	ENST00000372391.2	-	4	595	c.590G>T	c.(589-591)cGa>cTa	p.R197L	DLG5_ENST00000372388.2_Missense_Mutation_p.R197L	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	197					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CGACATGGCTCGCACGCACTG	0.587000													22	77					7.38237e-10	8.7644e-10	1	1	0
FCHSD1	89848	broad.mit.edu	37	5	141023943	141023943	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:141023943C>T	ENST00000435817.2	-	17	1755	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	FCHSD1_ENST00000523856.1_5'UTR|FCHSD1_ENST00000522783.1_Missense_Mutation_p.E495K|FCHSD1_ENST00000522126.1_3'UTR	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	569	SH3 2.								FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGCCCCCTCAGGGAAGCTC	0.632000													8	48					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196718096	196718096	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:196718096G>T	ENST00000312428.6	-	46	8852	c.8752C>A	c.(8752-8754)Ctc>Atc	p.L2918I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2918					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGGCTCCGAGGTAAGCAACC	0.498000													18	80					2.4624e-09	2.8829e-09	1	1	0
ERCC8	1161	broad.mit.edu	37	5	60183312	60183312	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:60183312C>A	ENST00000426742.2	-	12	1337	c.903G>T	c.(901-903)ctG>ctT	p.L301L	ERCC8_ENST00000265038.5_Silent_p.L359L|ERCC8_ENST00000543101.1_Silent_p.L206L|ERCC8_ENST00000462279.1_5'UTR			Q13216	ERCC8_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 8	359					positive regulation of DNA repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein polyubiquitination|response to oxidative stress|response to UV|transcription-coupled nucleotide-excision repair	Cul4A-RING ubiquitin ligase complex|nuclear matrix|nucleoplasm|nucleotide-excision repair complex|soluble fraction	protein binding|protein complex binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14		Lung NSC(810;1.51e-06)|Prostate(74;0.0322)|Ovarian(174;0.0481)|Breast(144;0.077)				GAACCCAAGCCAGAATGTTGC	0.348000													14	69					8.34094e-07	9.40363e-07	1	1	0
MYH8	4626	broad.mit.edu	37	17	10312460	10312460	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:10312460G>A	ENST00000403437.2	-	17	2013	c.1919C>T	c.(1918-1920)gCt>gTt	p.A640V	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	640	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTTTTTCTTAGCACCTTTCTT	0.343000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				7	22					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180381752	180381752	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:180381752C>T	ENST00000273654.4	-	8	984	c.365G>A	c.(364-366)aGa>aAa	p.R122K	CCDC39_ENST00000442201.2_Missense_Mutation_p.R38K			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	38					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAAGCTTGCTCTTTCATCCTT	0.323000													12	53					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209796440	209796440	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:209796440C>A	ENST00000391911.1	-	16	2832	c.2443G>T	c.(2443-2445)Ggc>Tgc	p.G815C	LAMB3_ENST00000367030.3_Missense_Mutation_p.G815C|LAMB3_ENST00000356082.4_Missense_Mutation_p.G815C	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	815	Domain alpha.			G -> A (in Ref. 1; AAA61834).	cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CAGCGGGAGCCACAGGCTGTG	0.642000													14	117					2.32078e-09	2.72549e-09	1	1	0
ZSCAN10	84891	broad.mit.edu	37	16	3139400	3139400	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:3139400G>T	ENST00000252463.2	-	5	1957	c.1870C>A	c.(1870-1872)Cgc>Agc	p.R624S	ZSCAN10_ENST00000575108.1_Missense_Mutation_p.R285S|ZSCAN10_ENST00000538082.2_Missense_Mutation_p.R542S	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	624					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CGGCGATGGCGGGCCAGGTTG	0.711000													9	62					1.58986e-06	1.77924e-06	1	1	0
GFOD2	81577	broad.mit.edu	37	16	67709826	67709826	+	Silent	SNP	G	G	A	rs142530623		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:67709826G>A	ENST00000268797.7	-	3	735	c.390C>T	c.(388-390)ttC>ttT	p.F130F	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	130						proteinaceous extracellular matrix	binding|oxidoreductase activity	p.F130F(1)		breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TCATGCGCACGAAGGCAGGCA	0.592000													17	134					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95121315	95121315	+	Splice_Site	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:95121315C>G	ENST00000371501.4	-	28	2991		c.e28-1		MYOF_ENST00000359263.4_Splice_Site|MYOF_ENST00000371502.4_Splice_Site|MYOF_ENST00000358334.5_Splice_Site			Q9NZM1	MYOF_HUMAN	myoferlin						blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TATCGCCGTTCTTACAAAACA	0.428000													21	92					0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53086595	53086595	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:53086595A>T	ENST00000540331.1	+	5	1706	c.1481A>T	c.(1480-1482)cAt>cTt	p.H494L	ZNF701_ENST00000391785.3_Missense_Mutation_p.H428L|CTD-3099C6.7_ENST00000599222.1_RNA|ZNF701_ENST00000301093.2_Missense_Mutation_p.H494L	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		CTTGCATGTCATCGTAGACTT	0.358000													13	32					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96540285	96540285	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:96540285G>T	ENST00000371321.3	+	4	593	c.511G>T	c.(511-513)Ggc>Tgc	p.G171C	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	171					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TTTCATCCTGGGCTGTGCTCC	0.328000													52	246					3.98911e-17	5.39933e-17	1	1	0
DIDO1	11083	broad.mit.edu	37	20	61526418	61526418	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:61526418C>G	ENST00000266070.4	-	9	2639	c.2314G>C	c.(2314-2316)Gag>Cag	p.E772Q	DIDO1_ENST00000395343.1_Missense_Mutation_p.E772Q|DIDO1_ENST00000395340.1_Missense_Mutation_p.E772Q|DIDO1_ENST00000395335.2_Missense_Mutation_p.E772Q	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	772	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCTGGCCTCTCTTTCCACGTG	0.498000													40	327					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351617	156351617	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156351617G>A	ENST00000400992.2	+	6	1133	c.765G>A	c.(763-765)gcG>gcA	p.A255A	RHBG_ENST00000368246.2_Silent_p.A287A|RHBG_ENST00000255013.3_Silent_p.A218A|RHBG_ENST00000537040.1_Silent_p.A125A|RHBG_ENST00000451864.2_Intron|RHBG_ENST00000368249.1_Silent_p.A287A			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	287					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					AAAATGCAGCGCTGGCTGGAG	0.572000													12	103					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56902268	56902268	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:56902268G>A	ENST00000438926.2	+	3	518	c.489G>A	c.(487-489)acG>acA	p.T163T	SLC12A3_ENST00000262502.5_Silent_p.T162T|SLC12A3_ENST00000566786.1_Silent_p.T162T|SLC12A3_ENST00000563236.1_Silent_p.T163T	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	163			T -> M (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CCTGGATTACGGCCCAGGCAG	0.612000													9	61					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21675117	21675117	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:21675117G>A	ENST00000379499.2	-	1	1331	c.790C>T	c.(790-792)Cgc>Tgc	p.R264C		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	264								p.R264C(1)		cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						AGCGGCTGGCGGGAGGGCGTC	0.692000													7	11					0	0	1	0	0
C1orf54	79630	broad.mit.edu	37	1	150249041	150249041	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:150249041G>T	ENST00000369102.1	+	6	1070		c.e6+1		C1orf54_ENST00000369098.3_Splice_Site|C1orf54_ENST00000369099.3_Splice_Site			Q8WWF1	CA054_HUMAN	chromosome 1 open reading frame 54							extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACGGAACCTGTGAGTTGATT	0.498000													9	80					1.12685e-05	1.24461e-05	1	1	0
AE000661.37	0	broad.mit.edu	37	14	22925720	22925720	+	RNA	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:22925720T>G	ENST00000514473.2	-	0	225				TRDJ2_ENST00000390475.1_RNA																							GGAACACAACTCATCGTGGAA	0.428000													34	124					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56047368	56047368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:56047368G>A	ENST00000244728.5	-	2	446	c.49C>T	c.(49-51)Cag>Tag	p.Q17*	COL21A1_ENST00000370819.1_Nonsense_Mutation_p.Q17*|COL21A1_ENST00000535941.1_Nonsense_Mutation_p.Q17*	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	17					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACAGAATTCTGAAGAAGCAGC	0.343000													7	16					0	0	1	0	0
TEX19	400629	broad.mit.edu	37	17	80320402	80320402	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:80320402C>A	ENST00000333437.4	+	2	686	c.376C>A	c.(376-378)Cct>Act	p.P126T		NM_207459.3	NP_997342.1	Q8NA77	TEX19_HUMAN	testis expressed 19	126						nucleus				breast(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6						TGAACTATGGCCTCAGGAGGC	0.637000													22	168					2.44723e-14	3.15651e-14	1	1	0
MYH15	22989	broad.mit.edu	37	3	108140049	108140049	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:108140049T>G	ENST00000273353.3	-	29	3831	c.3775A>C	c.(3775-3777)Aaa>Caa	p.K1259Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1259						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTACAGAGTTTCTCAGCATTT	0.478000													3	93					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9965209	9965209	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:9965209G>T	ENST00000264833.4	-	6	1203	c.1018C>A	c.(1018-1020)Cag>Aag	p.Q340K	OLFM2_ENST00000590841.1_Missense_Mutation_p.Q262K	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	340	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CCCGCGTTCTGGTTGGTGGTG	0.657000													19	83					3.62473e-10	4.34397e-10	1	1	0
U2SURP	23350	broad.mit.edu	37	3	142739511	142739511	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:142739511G>A	ENST00000473835.2	+	8	799	c.709G>A	c.(709-711)Gat>Aat	p.D237N	U2SURP_ENST00000397933.2_5'UTR|U2SURP_ENST00000493598.2_Missense_Mutation_p.D237N	NM_001080415.1	NP_001073884.1	O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	237					RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						TCCTCAGTCAGATTCTGATGG	0.368000													14	20					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230982	36230982	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:36230982C>A	ENST00000303965.4	-	2	616	c.127G>T	c.(127-129)Gac>Tac	p.D43Y		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	43	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGCAGGCTGTCATTTATTGCT	0.368000													23	41					8.24728e-16	1.08962e-15	1	1	0
CR1	1378	broad.mit.edu	37	1	207789975	207789975	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:207789975C>A	ENST00000367049.4	+	41	6717	c.6717C>A	c.(6715-6717)ccC>ccA	p.P2239P	CR1_ENST00000367052.1_Silent_p.P1789P|CR1_ENST00000367053.1_Silent_p.P1789P|CR1_ENST00000400960.2_Silent_p.P1789P|CR1_ENST00000367051.1_Silent_p.P1789P	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1789					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CAGGAACTCCCTTTGGAGATA	0.428000													23	183					1.64293e-13	2.09777e-13	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228509303	228509303	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:228509303G>A	ENST00000570156.2	+	66	17706	c.17632G>A	c.(17632-17634)Gtg>Atg	p.V5878M	OBSCN_ENST00000422127.1_Missense_Mutation_p.V4921M|OBSCN_ENST00000284548.11_Missense_Mutation_p.V4921M|OBSCN_ENST00000366709.4_Missense_Mutation_p.V2040M|OBSCN_ENST00000366707.4_Missense_Mutation_p.V2555M	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4921					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGAGTGTGTCGTGGCCAGCAA	0.637000													4	51					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114511194	114511194	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:114511194C>T	ENST00000369558.1	+	13	2927	c.2695C>T	c.(2695-2697)Ccc>Tcc	p.P899S	HIPK1_ENST00000426820.2_Missense_Mutation_p.P899S|HIPK1_ENST00000369559.4_Missense_Mutation_p.P899S|HIPK1_ENST00000340480.4_Missense_Mutation_p.P525S|HIPK1_ENST00000369553.1_Missense_Mutation_p.P505S|HIPK1_ENST00000406344.1_Missense_Mutation_p.P505S|HIPK1_ENST00000369554.2_Missense_Mutation_p.P854S|HIPK1_ENST00000369555.2_Missense_Mutation_p.P854S|HIPK1_ENST00000369561.4_Missense_Mutation_p.P865S			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	899	Interaction with TP53.|Required for localization to nuclear speckles (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCAGATACTCCCAGCCCTCC	0.488000													17	107					0	0	1	0	0
U2SURP	23350	broad.mit.edu	37	3	142754944	142754944	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:142754944G>A	ENST00000397933.2	+	19	2117	c.835G>A	c.(835-837)Gag>Aag	p.E279K	U2SURP_ENST00000473835.2_Missense_Mutation_p.E688K|U2SURP_ENST00000493598.2_Missense_Mutation_p.E687K			O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	688	RRM.				RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						AAAGGAAACAGAGGTAGGCAG	0.353000													6	33					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173912666	173912666	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:173912666G>A	ENST00000367696.2	-	18	3400	c.3049C>T	c.(3049-3051)Cct>Tct	p.P1017S	RC3H1_ENST00000258349.4_Missense_Mutation_p.P1017S|RC3H1_ENST00000367694.2_Missense_Mutation_p.P1008S			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	1017					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						ATCATCCCAGGCCATTTTGGA	0.542000													39	262					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118315019	118315019	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:118315019G>T	ENST00000369221.2	+	8	839	c.811_splice	c.e8+1	p.G271_splice		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	271					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AATCTGGGAAGGTAGAACTAT	0.398000													21	130					1.17739e-12	1.47611e-12	1	1	0
BRD3	8019	broad.mit.edu	37	9	136917482	136917482	+	Silent	SNP	G	G	A	rs61731642	byFrequency	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:136917482G>A	ENST00000303407.7	-	3	482	c.297C>T	c.(295-297)agC>agT	p.S99S	BRD3_ENST00000357885.2_Silent_p.S99S|BRD3_ENST00000371834.2_Silent_p.S99S	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	99	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		GCATACATTCGCTTGCACTCC	0.373000			T	C15orf55	lethal midline carcinoma of young people								26	19					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2951227	2951227	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:2951227T>A	ENST00000261596.4	-	4	654	c.416A>T	c.(415-417)cAc>cTc	p.H139L	RP11-737O24.2_ENST00000584431.1_RNA	NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	139					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		TTCCAAGACGTGTGAGATGTC	0.403000													19	53					0	0	1	0	0
MFAP3	4238	broad.mit.edu	37	5	153432490	153432490	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:153432490G>T	ENST00000436816.1	+	3	525	c.306G>T	c.(304-306)tgG>tgT	p.W102C	MFAP3_ENST00000439768.2_5'UTR|MFAP3_ENST00000322602.5_Missense_Mutation_p.W102C	NM_001242336.1|NM_005927.4	NP_001229265.1|NP_005918.1	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3	102	Ig-like C2-type.					integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)	7	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		GTGGAAAGTGGTTGGTTTCTG	0.388000													21	98					9.86323e-18	1.34515e-17	1	1	0
TMCC3	57458	broad.mit.edu	37	12	94975691	94975691	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:94975691C>T	ENST00000261226.4	-	2	833	c.702G>A	c.(700-702)gcG>gcA	p.A234A	TMCC3_ENST00000551457.1_Silent_p.A203A	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	234						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CCCTGGCACTCGCCTCTGGCC	0.527000													17	98					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31327191	31327191	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:31327191G>T	ENST00000597505.1	-	4	724	c.725C>A	c.(724-726)cCc>cAc	p.P242H	DCDC1_ENST00000452803.1_Missense_Mutation_p.P242H			P59894	DCDC1_HUMAN	doublecortin domain containing 1	242	Doublecortin.				intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ATTTAAAAAGGGCTCTCCCGT	0.408000													24	126					8.24728e-16	1.08962e-15	1	1	0
TENM2	57451	broad.mit.edu	37	5	167643928	167643928	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:167643928G>T	ENST00000519204.1	+	21	3988		c.e21+1		TENM2_ENST00000520394.1_Splice_Site|TENM2_ENST00000403607.2_Splice_Site|TENM2_ENST00000545108.1_Splice_Site|TENM2_ENST00000518659.1_Splice_Site					teneurin transmembrane protein 2																		TGTAGCCCAGGTGAGACTCTT	0.527000													38	96					8.94452e-30	1.34256e-29	1	1	0
SEMA4A	64218	broad.mit.edu	37	1	156130745	156130745	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156130745C>T	ENST00000368285.3	+	8	1002	c.735C>T	c.(733-735)ttC>ttT	p.F245F	SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368282.1_Silent_p.F245F|SEMA4A_ENST00000355014.2_Silent_p.F245F|SEMA4A_ENST00000368286.2_Silent_p.F113F|SEMA4A_ENST00000368284.1_Silent_p.F113F	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	245	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					TCGTCTACTTCTTCTTCGAGG	0.642000													27	226					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756672	124756672	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:124756672A>C	ENST00000306534.3	-	16	2967	c.2482T>G	c.(2482-2484)Tat>Gat	p.Y828D	ROBO4_ENST00000533054.1_Missense_Mutation_p.Y683D|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	828					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ATGTACCCATAGGTGGTGGGG	0.607000													58	64					0	0	1	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380095	30380095	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:30380095C>A	ENST00000493196.1	-	4	812	c.712G>T	c.(712-714)Gaa>Taa	p.E238*	RWDD2B_ENST00000486719.1_5'UTR	NM_016940.2	NP_058636.1	P57060	RWD2B_HUMAN	RWD domain containing 2B	238										endometrium(1)|kidney(1)|large_intestine(8)|lung(2)	12						GACCAGAATTCTTCACAGGCA	0.418000													15	63					5.3912e-06	5.98935e-06	1	1	0
EPHB2	2048	broad.mit.edu	37	1	23110993	23110993	+	Missense_Mutation	SNP	C	C	T	rs139122679		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:23110993C>T	ENST00000400191.3	+	3	253	c.235C>T	c.(235-237)Cgg>Tgg	p.R79W	EPHB2_ENST00000374630.3_Missense_Mutation_p.R79W|EPHB2_ENST00000374632.3_Missense_Mutation_p.R79W|EPHB2_ENST00000544305.1_Missense_Mutation_p.R79W|EPHB2_ENST00000374627.1_Missense_Mutation_p.R73W	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	79					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity	p.R79W(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CAAGTTTATCCGGCGCCGTGG	0.577000													4	40					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5144015	5144015	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:5144015C>T	ENST00000159111.4	+	19	2806	c.2588C>T	c.(2587-2589)tCa>tTa	p.S863L	KDM4B_ENST00000536461.1_Missense_Mutation_p.S897L	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	863					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						AAGAAGGTGTCAGGTGCCTGT	0.647000													10	49					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69320611	69320611	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:69320611C>T	ENST00000260364.5	+	4	478	c.177C>T	c.(175-177)atC>atT	p.I59I	NOX5_ENST00000530406.2_Silent_p.I77I|NOX5_ENST00000455873.3_Silent_p.I70I|NOX5_ENST00000388866.3_Silent_p.I77I|NOX5_ENST00000448182.3_Silent_p.I59I|RP11-809H16.2_ENST00000557966.1_RNA			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	77	EF-hand 2.|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						GTGGCACCATCACCCTCCAGG	0.547000													25	138					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909581	123909581	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:123909581A>T	ENST00000330487.5	-	1	136	c.128T>A	c.(127-129)aTc>aAc	p.I43N		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CACCAGCAGGATGAGGAGGTT	0.572000													18	184					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65476106	65476106	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:65476106G>T	ENST00000519389.1	+	17	3171	c.2992G>T	c.(2992-2994)Ggg>Tgg	p.G998W	HEPH_ENST00000419594.1_Missense_Mutation_p.G755W|HEPH_ENST00000441993.2_Missense_Mutation_p.G947W|HEPH_ENST00000343002.2_Missense_Mutation_p.G944W|HEPH_ENST00000336279.5_Missense_Mutation_p.G677W|HEPH_ENST00000374727.3_Missense_Mutation_p.G947W			Q9BQS7	HEPH_HUMAN	hephaestin	944	Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GGCAACCCATGGGTCCCAGGA	0.418000													32	25					2.95478e-19	4.07352e-19	1	1	0
POU4F2	5458	broad.mit.edu	37	4	147561487	147561487	+	Missense_Mutation	SNP	G	G	T	rs3827593		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:147561487G>T	ENST00000281321.3	+	2	1005	c.757G>T	c.(757-759)Gcc>Tcc	p.A253S		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	253	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					CGACGTGGACGCCGACCCGCG	0.687000													3	22					0.004672	0.0048704	1	1	0
SAMD9L	219285	broad.mit.edu	37	7	92765060	92765060	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:92765060C>T	ENST00000318238.4	-	5	1441	c.225G>A	c.(223-225)ttG>ttA	p.L75L	SAMD9L_ENST00000411955.1_Silent_p.L75L|SAMD9L_ENST00000437805.1_Silent_p.L75L	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	75	SAM.									central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ACTTACTATTCAATTTGTTGT	0.393000													51	90					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91131903	91131903	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:91131903G>T	ENST00000373094.1	+	2	1509	c.664G>T	c.(664-666)Gaa>Taa	p.E222*	PCDH11X_ENST00000361724.1_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000504220.1_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000395337.2_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.E222*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.E222*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	222	Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AGTAAAGGTTGAAGATGGTGG	0.408000													40	105					3.70713e-34	5.58639e-34	1	1	0
BAZ1B	9031	broad.mit.edu	37	7	72891683	72891683	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:72891683T>A	ENST00000339594.4	-	7	2446	c.2108A>T	c.(2107-2109)gAg>gTg	p.E703V	BAZ1B_ENST00000404251.1_Missense_Mutation_p.E703V	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	703					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTCGCTTTCCTCCTGAACATC	0.473000													15	137					0	0	1	0	0
MEF2D	4209	broad.mit.edu	37	1	156446948	156446948	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156446948C>A	ENST00000348159.4	-	7	1191	c.711G>T	c.(709-711)gtG>gtT	p.V237V	MEF2D_ENST00000464356.1_Intron|MEF2D_ENST00000353795.3_Silent_p.V191V|MEF2D_ENST00000340875.5_Silent_p.V236V|MEF2D_ENST00000368240.2_Silent_p.V237V|MEF2D_ENST00000360595.3_Silent_p.V237V	NM_005920.2	NP_005911.1	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	237					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	15	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCCATTGGCCACAGGGAGGA	0.597000													9	86					0.0692343	0.0702497	1	1	0
DOK2	9046	broad.mit.edu	37	8	21767437	21767437	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:21767437G>T	ENST00000276420.4	-	5	882	c.624C>A	c.(622-624)acC>acA	p.T208T	DOK2_ENST00000544659.1_Silent_p.T54T	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	208	IRS-type PTB.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		CAAAGGAAAAGGTTACCTGGA	0.527000													8	44					9.70103e-10	1.14992e-09	1	1	0
TROAP	10024	broad.mit.edu	37	12	49724403	49724403	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:49724403A>G	ENST00000551245.1	+	13	1886	c.1775A>G	c.(1774-1776)tAc>tGc	p.Y592C	TROAP_ENST00000547923.1_Intron|TROAP_ENST00000257909.3_Missense_Mutation_p.Y592C			Q12815	TROAP_HUMAN	trophinin associated protein	592	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CTAGAGTCCTACTGTAGGATT	0.617000													3	74					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24582457	24582457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:24582457C>T	ENST00000319715.4	+	18	4502	c.4070C>T	c.(4069-4071)tCa>tTa	p.S1357L	RBBP6_ENST00000381039.3_Missense_Mutation_p.S517L|RBBP6_ENST00000348022.2_Missense_Mutation_p.S1323L	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1357					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		ACAAAGCCATCAAATATAGTC	0.358000													3	30					0	0	1	0	0
FAM153C	653316	broad.mit.edu	37	5	177466387	177466387	+	Splice_Site	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:177466387G>A	ENST00000398106.2	+	5	561		c.e5-1		FAM153C_ENST00000511189.1_Splice_Site|FAM153C_ENST00000507848.1_Splice_Site					family with sequence similarity 153, member C											kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTCATTACAGACATCCTTGG	0.443000													21	409					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44796638	44796638	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:44796638A>G	ENST00000309315.4	+	4	381	c.258A>G	c.(256-258)ccA>ccG	p.P86P	ZMIZ2_ENST00000441627.1_Silent_p.P86P|ZMIZ2_ENST00000433667.1_Intron|ZMIZ2_ENST00000413916.1_Intron|ZMIZ2_ENST00000265346.7_Silent_p.P86P	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	86	Gly-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TGACCTCCCCACAGTGCCTGG	0.677000													9	88					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99126216	99126216	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:99126216G>T	ENST00000357310.1	+	26	4067	c.3490G>T	c.(3490-3492)Ggg>Tgg	p.G1164W	APAF1_ENST00000550527.1_Missense_Mutation_p.G1196W|APAF1_ENST00000359972.2_Missense_Mutation_p.G1153W|APAF1_ENST00000552268.1_Missense_Mutation_p.W325L|APAF1_ENST00000551964.1_Missense_Mutation_p.G1207W|APAF1_ENST00000549007.1_Missense_Mutation_p.G1122W|APAF1_ENST00000339433.3_Missense_Mutation_p.G1122W|APAF1_ENST00000547045.1_Missense_Mutation_p.G1164W|APAF1_ENST00000333991.1_Missense_Mutation_p.W325L	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	1207					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	CGTTGTCACTGGGGAATCCTC	0.388000													10	39					5.50884e-06	6.10222e-06	1	1	0
COL6A3	1293	broad.mit.edu	37	2	238243417	238243417	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:238243417G>A	ENST00000295550.4	-	41	9533	c.9081C>T	c.(9079-9081)gcC>gcT	p.A3027A	COL6A3_ENST00000346358.4_Silent_p.A2827A|COL6A3_ENST00000472056.1_Silent_p.A2420A|COL6A3_ENST00000409809.1_Silent_p.A2821A|COL6A3_ENST00000347401.3_Silent_p.A2826A|COL6A3_ENST00000353578.4_Silent_p.A2821A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	3027	Fibronectin type-III.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACTGATCATGGGCTGAGGTGA	0.567000													13	87					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726783	46726783	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:46726783G>T	ENST00000311764.2	+	5	1763	c.1533G>T	c.(1531-1533)ctG>ctT	p.L511L		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGGGCAACCTGCGTGGGCATT	0.642000													18	153					4.63292e-17	6.2401e-17	1	1	0
IL21R	50615	broad.mit.edu	37	16	27460101	27460101	+	Missense_Mutation	SNP	G	G	A	rs36031126		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:27460101G>A	ENST00000337929.3	+	9	1587	c.1114G>A	c.(1114-1116)Ggc>Agc	p.G372S	IL21R_ENST00000564089.1_Missense_Mutation_p.G372S|IL21R_ENST00000395755.1_Missense_Mutation_p.G372S|IL21R-AS1_ENST00000563191.1_RNA|IL21R_ENST00000395754.4_Missense_Mutation_p.G372S	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	372					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						TCGGCCATACGGCCTGGTGTC	0.627000			T	BCL6	NHL								23	116					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740628	140740628	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140740628T>A	ENST00000522605.1	+	1	926	c.926T>A	c.(925-927)tTt>tAt	p.F309Y	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTTGGATTTTGAGATTGCA	0.383000													9	21					0	0	1	0	0
PRKAG2	51422	broad.mit.edu	37	7	151271982	151271982	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:151271982G>A	ENST00000287878.4	-	8	1504	c.1000C>T	c.(1000-1002)Cct>Tct	p.P334S	PRKAG2_ENST00000433631.2_Missense_Mutation_p.P209S|PRKAG2_ENST00000392801.2_Missense_Mutation_p.P290S|PRKAG2_ENST00000492843.1_Missense_Mutation_p.P210S|PRKAG2_ENST00000418337.2_Missense_Mutation_p.P93S	NM_016203.3	NP_057287.2	Q9UGJ0	AAKG2_HUMAN	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	334	CBS 1.				ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|upper_aerodigestive_tract(1)	26	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CTTACCATAGGTGATTTATAG	0.299000													5	44					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5827304	5827304	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:5827304G>A	ENST00000324989.7	-	13	1974	c.1886C>T	c.(1885-1887)cCc>cTc	p.P629L	EVC_ENST00000382674.2_Intron|CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000397890.2_Missense_Mutation_p.P515L|CRMP1_ENST00000512574.1_Missense_Mutation_p.P513L	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	515					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		TGAAGGAGCGGGAGTTGCATA	0.517000													30	66					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127572586	127572586	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:127572586C>T	ENST00000373580.3	+	8	1854	c.1854C>T	c.(1852-1854)aaC>aaT	p.N618N	OLFML2A_ENST00000288815.5_Silent_p.N404N	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	618	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CGTTCCTCAACGAGCACGCCT	0.632000													11	78					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59518564	59518564	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:59518564G>A	ENST00000038176.3	-	12	1002	c.790C>T	c.(790-792)Ctg>Ttg	p.L264L	NSMAF_ENST00000519858.1_5'UTR|NSMAF_ENST00000427130.2_Silent_p.L295L	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	264					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				TCGGAACACAGATCATCTTCT	0.338000													5	34					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849885	73849885	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:73849885C>A	ENST00000523207.1	+	3	2883	c.2295C>A	c.(2293-2295)gaC>gaA	p.D765E		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	765					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CCCAGGGAGACAGACCCTTGC	0.567000													22	199					1.9806e-07	2.25634e-07	1	1	0
OR8A1	390275	broad.mit.edu	37	11	124440489	124440489	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:124440489A>G	ENST00000284287.3	+	1	597	c.525A>G	c.(523-525)atA>atG	p.I175M		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GCTCCACAATAGAAACTGGCC	0.502000													20	111					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17612122	17612122	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:17612122C>T	ENST00000252595.7	+	11	1774	c.1677C>T	c.(1675-1677)ccC>ccT	p.P559P	CTD-3131K8.2_ENST00000596643.1_lincRNA|SLC27A1_ENST00000442725.1_Silent_p.P559P|SLC27A1_ENST00000598848.1_Intron|SLC27A1_ENST00000598424.1_Silent_p.P380P	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	559					cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TCGCAGACCCCCACAGCCTGC	0.667000													14	51					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1471251	1471251	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:1471251G>A	ENST00000331035.4	+	6	817	c.468G>A	c.(466-468)acG>acA	p.T156T	IL3RA_ENST00000381469.2_Silent_p.T78T	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	156						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTACAAAACGGATGCTCAGG	0.602000													62	307					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176002325	176002325	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:176002325C>A	ENST00000510636.1	+	9	940	c.666C>A	c.(664-666)tcC>tcA	p.S222S	CDHR2_ENST00000261944.5_Silent_p.S222S|CDHR2_ENST00000506348.1_Silent_p.S222S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	222	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TCCAGTGCTCCCTGCCTGTCT	0.637000													18	82					1.67942e-08	1.94526e-08	1	1	0
CRYBA2	1412	broad.mit.edu	37	2	219855630	219855630	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:219855630C>A	ENST00000295728.2	-	3	626	c.390G>T	c.(388-390)ctG>ctT	p.L130L	CRYBA2_ENST00000487181.1_5'UTR|CRYBA2_ENST00000392096.2_Silent_p.L130L	NM_057093.1	NP_476434.1	P53672	CRBA2_HUMAN	crystallin, beta A2	130	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens			endometrium(1)|lung(3)|prostate(1)	5		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCATGGAGGGCAGGGATGGGT	0.572000													22	158					2.98393e-07	3.37912e-07	1	1	0
KRT6A	3853	broad.mit.edu	37	12	52885386	52885386	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:52885386C>A	ENST00000330722.6	-	2	743	c.675G>T	c.(673-675)ctG>ctT	p.L225L		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	225	Coil 1B.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAATGCTGTCCAGCTGCCTCC	0.557000													74	126					9.90312e-32	1.48938e-31	1	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77396132	77396132	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:77396132G>A	ENST00000282849.5	-	7	1504	c.1086C>T	c.(1084-1086)gaC>gaT	p.D362D		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	362	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TCAGAGACTGGTCTGCATGAT	0.393000													19	69					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130898744	130898744	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:130898744G>C	ENST00000392984.3	-	3	1719	c.976C>G	c.(976-978)Caa>Gaa	p.Q326E	CCDC74B_ENST00000409943.3_Missense_Mutation_p.Q158E|CCDC74B_ENST00000310463.6_Missense_Mutation_p.Q224E|CCDC74B_ENST00000409128.1_Missense_Mutation_p.Q200E			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	224										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					GCCTGCCCTTGTACCCCAGGA	0.567000													22	141					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66333375	66333375	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:66333375G>C	ENST00000310325.5	-	7	1000	c.891C>G	c.(889-891)gcC>gcG	p.A297A		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	297					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TGACTGAGAAGGCCCAGCAGG	0.612000													23	46					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200635097	200635097	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:200635097G>C	ENST00000447706.2	-	2	923	c.772C>G	c.(772-774)Ctt>Gtt	p.L258V	DDX59_ENST00000367348.3_Missense_Mutation_p.L258V|DDX59_ENST00000331314.6_Missense_Mutation_p.L258V			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	258	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						ACAGGAAGAAGAAAAGCAGCT	0.413000													12	90					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064609	78064609	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:78064609C>A	ENST00000299642.4	+	3	577	c.492C>A	c.(490-492)gaC>gaA	p.D164E	CLEC3A_ENST00000575655.1_Missense_Mutation_p.D155E|RP11-281J9.2_ENST00000563114.1_RNA|CLEC3A_ENST00000565808.1_3'UTR	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	155	C-type lectin.				skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						TCAACTGGGACCGTGCACAGC	0.532000													26	145					7.01153e-11	8.55093e-11	1	1	0
SIGLECL1	284369	broad.mit.edu	37	19	51768884	51768884	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:51768884G>T	ENST00000316401.7	+	3	666	c.285G>T	c.(283-285)ttG>ttT	p.L95F	CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000597824.1_Intron|SIGLECL1_ENST00000593968.1_Intron	NM_173635.1	NP_775906.1			SIGLEC family like 1																		CCCATGCTTTGAGCATCCTAC	0.552000													25	164					4.4194e-11	5.42446e-11	1	1	0
MED7	9443	broad.mit.edu	37	5	156566358	156566358	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:156566358C>A	ENST00000286317.5	-	2	466	c.85G>T	c.(85-87)Ggc>Tgc	p.G29C	MED7_ENST00000420343.1_Missense_Mutation_p.G29C	NM_004270.4	NP_004261.1	O43513	MED7_HUMAN	mediator complex subunit 7	29					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity			kidney(1)|large_intestine(1)|lung(3)|urinary_tract(2)	7	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGAGCTAAGCCTTCTTGAATA	0.428000													20	59					2.4624e-09	2.8829e-09	1	1	0
SH2D5	400745	broad.mit.edu	37	1	21050668	21050668	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:21050668C>T	ENST00000375031.1	-	6	1079	c.455G>A	c.(454-456)cGc>cAc	p.R152H	SH2D5_ENST00000460804.1_5'UTR|SH2D5_ENST00000444387.2_Missense_Mutation_p.R236H	NM_001103160.1	NP_001096630.1	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5	152										lung(4)|prostate(1)|upper_aerodigestive_tract(1)	6		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCCTTCTTGCGCACCAGCGT	0.672000													27	125					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156502815	156502815	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156502815C>T	ENST00000361170.2	-	32	4070	c.4060G>A	c.(4060-4062)Gag>Aag	p.E1354K		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1354					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCATCTGCCTCTAGTCCTTCA	0.587000													15	100					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209789895	209789895	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:209789895C>A	ENST00000391911.1	-	21	3692	c.3303G>T	c.(3301-3303)caG>caT	p.Q1101H	LAMB3_ENST00000367030.3_Missense_Mutation_p.Q1101H|LAMB3_ENST00000356082.4_Missense_Mutation_p.Q1101H	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1101	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCCGGGCACCCTGCTCACCCA	0.502000													33	246					2.05212e-20	2.89197e-20	1	1	0
DMBT1	1755	broad.mit.edu	37	10	124344818	124344818	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:124344818G>A	ENST00000338354.3	+	15	1558	c.1452G>A	c.(1450-1452)tcG>tcA	p.S484S	DMBT1_ENST00000344338.3_Silent_p.S474S|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Silent_p.S474S|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Silent_p.S484S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	484					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TACCTGCATCGACAGTAGGTA	0.453000													44	248					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64691207	64691207	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:64691207A>T	ENST00000357395.3	+	114	20641	c.9497A>T	c.(9496-9498)gAc>gTc	p.D3166V	SYNE2_ENST00000441438.2_Missense_Mutation_p.D326V|SYNE2_ENST00000554805.1_Missense_Mutation_p.D564V|SYNE2_ENST00000555002.1_Missense_Mutation_p.D3438V|SYNE2_ENST00000555022.1_Missense_Mutation_p.D659V|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.D3166V|SYNE2_ENST00000358025.3_Missense_Mutation_p.D6804V|SYNE2_ENST00000554584.1_Missense_Mutation_p.D6697V|SYNE2_ENST00000344113.4_Missense_Mutation_p.D6781V|SYNE2_ENST00000458046.2_Missense_Mutation_p.D452V			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6781					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCCAGCTTCGACGAGGTAGAC	0.522000													51	100					0	0	1	0	0
ETV2	2116	broad.mit.edu	37	19	36134253	36134253	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:36134253G>A	ENST00000379026.2	+	4	836	c.397G>A	c.(397-399)Gcc>Acc	p.A133T	ETV2_ENST00000403402.1_Missense_Mutation_p.A105T|ETV2_ENST00000379023.4_Intron|ETV2_ENST00000479824.1_Missense_Mutation_p.A12T|ETV2_ENST00000402764.2_Missense_Mutation_p.A105T			B9EIN1	B9EIN1_HUMAN	ets variant 2	105							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTGGAGCGGCGCCTCGCAGAC	0.726000													10	8					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419306	130419306	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:130419306C>A	ENST00000370904.1	-	11	1397	c.487G>T	c.(487-489)Gtg>Ttg	p.V163L	IGSF1_ENST00000370900.1_Missense_Mutation_p.V172L|IGSF1_ENST00000370901.4_Missense_Mutation_p.V172L|IGSF1_ENST00000370903.3_Missense_Mutation_p.V172L|IGSF1_ENST00000370910.1_Missense_Mutation_p.V163L|IGSF1_ENST00000361420.3_Missense_Mutation_p.V172L			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	172	Ig-like C2-type 2.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGGTAATCCACAGGCTCTGCA	0.493000													28	104					1.48458e-05	1.63497e-05	1	1	0
SYNCRIP	10492	broad.mit.edu	37	6	86324692	86324692	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:86324692C>T	ENST00000369622.3	-	11	2154	c.1654G>A	c.(1654-1656)Ggt>Agt	p.G552S	SYNCRIP_ENST00000355238.6_Intron|RP11-321N4.5_ENST00000503906.1_Intron	NM_001159675.1|NM_006372.4	NP_001153147.1|NP_006363.4	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	552	8 X 3 AA repeats of R-G-G.|Interaction with APOBEC1.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CCCCTCGCACCACGTACCCCG	0.587000													83	208					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121691550	121691550	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:121691550G>C	ENST00000393386.2	+	24	6564	c.6153G>C	c.(6151-6153)aaG>aaC	p.K2051N	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.K1184N	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2051	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACAGGGAAAAGAATCGAACTT	0.353000													16	116					0	0	1	0	0
TRIM21	6737	broad.mit.edu	37	11	4406703	4406703	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:4406703C>T	ENST00000254436.7	-	7	1352	c.1240G>A	c.(1240-1242)Gag>Aag	p.E414K	TRIM21_ENST00000543625.1_Missense_Mutation_p.E414K	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	414	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		ATGCCAGCCTCATAGTCCAGG	0.522000													4	4					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286465	57286465	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:57286465G>T	ENST00000391708.3	-	12	1717	c.1175C>A	c.(1174-1176)cCt>cAt	p.P392H	AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000221722.5_Missense_Mutation_p.P392H|ZIM2_ENST00000601070.1_Missense_Mutation_p.P392H|ZIM2_ENST00000599935.1_Missense_Mutation_p.P392H|ZIM2_ENST00000593711.1_Missense_Mutation_p.P392H	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CTGGACGGAAGGCTTTCTACC	0.463000													15	58					2.32078e-09	2.72549e-09	1	1	0
RHOU	58480	broad.mit.edu	37	1	228879188	228879188	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:228879188G>T	ENST00000366691.3	+	3	1144	c.478G>T	c.(478-480)Gga>Tga	p.G160*		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	160					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				CATCCTAGTTGGAACGCAGTC	0.532000													22	168					1.17739e-12	1.47611e-12	1	1	0
NTRK3	4916	broad.mit.edu	37	15	88420185	88420185	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:88420185T>A	ENST00000394480.1	-	19	2780	c.2459A>T	c.(2458-2460)tAc>tTc	p.Y820F	NTRK3_ENST00000557856.1_Missense_Mutation_p.Y812F|NTRK3_ENST00000355254.2_Missense_Mutation_p.Y820F|NTRK3_ENST00000357724.2_Missense_Mutation_p.Y826F|NTRK3_ENST00000360948.2_Missense_Mutation_p.Y834F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	834	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATGTCCAGGTAGATTGGGGT	0.532000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			34	103					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112024285	112024285	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:112024285G>A	ENST00000371959.3	-	9	2301	c.2302C>T	c.(2302-2304)Cgt>Tgt	p.R768C	AMOT_ENST00000524145.1_Missense_Mutation_p.R768C|AMOT_ENST00000371962.1_Missense_Mutation_p.R536C|AMOT_ENST00000304758.1_Missense_Mutation_p.R359C|AMOT_ENST00000371958.1_Missense_Mutation_p.R536C	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	768					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						TTCCGGGAACGCTGCTGGAGT	0.512000													79	212					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63330793	63330793	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:63330793C>A	ENST00000255695.1	-	1	62	c.4G>T	c.(4-6)Gct>Tct	p.A2S		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	2					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						CTTACCAAAGCCATCCTTCCT	0.433000													23	52					9.39395e-14	1.20553e-13	1	1	0
PDXK	8566	broad.mit.edu	37	21	45152394	45152394	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:45152394G>A	ENST00000327574.4	+	2	486	c.136G>A	c.(136-138)Gac>Aac	p.D46N	PDXK_ENST00000291565.4_Intron|PDXK_ENST00000468090.1_Intron|PDXK_ENST00000476313.1_Intron|PDXK_ENST00000398081.1_Intron			O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	107					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	AGAAAATAGCGACTTCATTCT	0.458000													19	99					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9967500	9967500	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:9967500G>T	ENST00000264833.4	-	5	855	c.670C>A	c.(670-672)Ccc>Acc	p.P224T	OLFM2_ENST00000590841.1_Missense_Mutation_p.P146T	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	224	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						TCCGCACTGGGGGCCATCGTG	0.662000													5	31					2.62144e-13	3.32486e-13	1	1	0
ISM1	140862	broad.mit.edu	37	20	13279806	13279806	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:13279806C>A	ENST00000262487.3	+	6	1101	c.1095C>A	c.(1093-1095)gcC>gcA	p.A365A	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	365	AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						AGCCCACTGCCCGGTACTGCA	0.632000													3	21					0.150653	0.152052	1	1	0
ABCC6	368	broad.mit.edu	37	16	16267179	16267179	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:16267179C>A	ENST00000205557.7	-	21	2778	c.2749G>T	c.(2749-2751)Gga>Tga	p.G917*		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	917					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GCTGGCCATCCTGCCCTGTCA	0.577000													9	93					0.00621372	0.00646872	1	1	0
LGR6	59352	broad.mit.edu	37	1	202287310	202287310	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:202287310G>A	ENST00000367278.3	+	18	1968	c.1879G>A	c.(1879-1881)Ggt>Agt	p.G627S	LGR6_ENST00000255432.7_Missense_Mutation_p.G575S|LGR6_ENST00000439764.2_Missense_Mutation_p.G488S	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	627						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						CCTGACCTTTGGTCAGTTCTC	0.622000													11	34					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6680116	6680116	+	Silent	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:6680116T>G	ENST00000309577.6	-	38	5887	c.5724A>C	c.(5722-5724)ccA>ccC	p.P1908P	CHD4_ENST00000544484.1_Silent_p.P1905P|CHD4_ENST00000357008.2_Silent_p.P1880P|CHD4_ENST00000544040.1_Silent_p.P1873P			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1880	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCACAGCAACTGGGGGAATTC	0.517000													79	435					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239025609	239025609	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:239025609G>C	ENST00000343063.3	+	5	1184	c.921G>C	c.(919-921)gcG>gcC	p.A307A	ESPNL_ENST00000409169.1_Intron	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	307										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GTTACACGGCGGCAGACCTGG	0.667000													11	57					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890499	139890499	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:139890499T>A	ENST00000303045.6	-	3	598	c.152A>T	c.(151-153)aAg>aTg	p.K51M	COL22A1_ENST00000435777.1_Missense_Mutation_p.K51M	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	51	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AAAGTCCTCCTTGCCCACGCT	0.637000										HNSCC(7;0.00092)			7	13					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15876551	15876551	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:15876551C>T	ENST00000277632.3	-	7	861	c.641G>A	c.(640-642)gGa>gAa	p.G214E	FAM188A_ENST00000477891.1_5'UTR	NM_024948.2	NP_079224.1	Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	214					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						CCTGCCATGTCCATATACAGG	0.318000													8	64					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233785159	233785159	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:233785159C>T	ENST00000264051.3	-	5	941	c.663G>A	c.(661-663)gaG>gaA	p.E221E	NGEF_ENST00000373552.4_Silent_p.E129E|NGEF_ENST00000409079.1_Silent_p.E129E	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	221	Poly-Glu.|Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity	p.E221E(3)		central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		cctcctcctcctcttcttctt	0.572000													3	94					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10470685	10470685	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:10470685T>A	ENST00000382483.3	-	4	1146	c.923A>T	c.(922-924)gAc>gTc	p.D308V		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	308					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTTCTTCATGTCATCGCCAGC	0.652000													26	133					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492827	21492827	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:21492827C>A	ENST00000377142.4	-	2	912	c.556G>T	c.(556-558)Gcc>Tcc	p.A186S	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	186					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TCGGCCCGGGCGCGCTTCATC	0.677000													30	50					2.42023e-17	3.28306e-17	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13753546	13753546	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:13753546T>C	ENST00000265104.4	-	63	10772	c.10668A>G	c.(10666-10668)ccA>ccG	p.P3556P		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3556					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCTTTCCAAATGGAATTTTCC	0.398000									Kartagener syndrome				21	124					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104427488	104427488	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:104427488C>T	ENST00000297579.5	+	1	547	c.270C>T	c.(268-270)ccC>ccT	p.P90P		NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	0					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						AAGAACCGCCCCTTGCTAACG	0.642000													17	229					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161495503	161495503	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:161495503T>C	ENST00000309758.4	+	1	1468	c.1055T>C	c.(1054-1056)cTg>cCg	p.L352P		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	352					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGAAGTTGCTGCAGGACTTC	0.612000													5	35					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160811529	160811529	+	Missense_Mutation	SNP	G	G	A	rs144670683		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:160811529G>A	ENST00000368034.4	-	2	401	c.224C>T	c.(223-225)cCt>cTt	p.P75L	CD244_ENST00000368032.2_Missense_Mutation_p.P75L|CD244_ENST00000322302.7_Missense_Mutation_p.P75L|CD244_ENST00000368033.3_Missense_Mutation_p.P75L	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	75	Ig-like 1.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGTATTGGAAGGCAAAGAGCC	0.448000													16	107					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412912	124412912	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:124412912G>T	ENST00000306842.2	-	1	663	c.639C>A	c.(637-639)gtC>gtA	p.V213V		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AAGAAATAAAGACAGTGACAA	0.458000													4	27					0.014758	0.0151563	1	1	0
RYR2	6262	broad.mit.edu	37	1	237711755	237711755	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:237711755G>T	ENST00000366574.2	+	26	3248	c.2931G>T	c.(2929-2931)aaG>aaT	p.K977N	RYR2_ENST00000542537.1_Missense_Mutation_p.K961N|RYR2_ENST00000360064.6_Missense_Mutation_p.K975N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	977	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGGATACAAGCCTGCCCCTA	0.423000													5	42					1.06961e-07	1.22587e-07	1	1	0
TRPA1	8989	broad.mit.edu	37	8	72968018	72968018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:72968018G>A	ENST00000262209.4	-	11	1474	c.1267C>T	c.(1267-1269)Cag>Tag	p.Q423*	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	423						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GGGCCCCCCTGTCTACATGCA	0.393000													18	31					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151316209	151316209	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:151316209G>A	ENST00000290524.4	-	9	883	c.705C>T	c.(703-705)ctC>ctT	p.L235L	RFX5_ENST00000452671.2_Silent_p.L235L|RFX5_ENST00000368870.2_Silent_p.L235L|RFX5_ENST00000452513.2_Silent_p.L195L	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	235						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGCAGAGATGAGATGCTGCT	0.582000													18	123					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182025	140182025	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140182025C>A	ENST00000522353.2	+	1	1243	c.1243C>A	c.(1243-1245)Cgc>Agc	p.R415S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.R415S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCTGGACCGCGAGAGCGT	0.637000													47	262					4.33383e-22	6.2463e-22	1	1	0
ABCB1	5243	broad.mit.edu	37	7	87144635	87144635	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:87144635G>A	ENST00000265724.3	-	26	3611	c.3194C>T	c.(3193-3195)aCg>aTg	p.T1065M	ABCB1_ENST00000543898.1_Missense_Mutation_p.T1001M|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1065	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CAGAGCCAGCGTCTGGCCCTT	0.572000													47	53					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736510	140736510	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140736510C>A	ENST00000571252.1	+	1	1743	c.1743C>A	c.(1741-1743)tcC>tcA	p.S581S	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCCCGCTCCGCAGATTCCG	0.592000													60	319					6.5469e-37	9.96438e-37	1	1	0
TTN	7273	broad.mit.edu	37	2	179456526	179456526	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:179456526G>A	ENST00000589042.1	-	303	60244	c.60020C>T	c.(60019-60021)tCt>tTt	p.S20007F	TTN_ENST00000342175.6_Missense_Mutation_p.S11134F|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S18366F|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S11067F|TTN_ENST00000460472.2_Missense_Mutation_p.S10942F|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S17439F|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18366	Fibronectin type-III 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGATTGGAGAACCACCATC	0.458000													3	63					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21382692	21382692	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:21382692G>A	ENST00000400602.2	-	12	1557	c.1522C>T	c.(1522-1524)Cat>Tat	p.H508Y	XPO4_ENST00000255305.6_Missense_Mutation_p.H508Y	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	508					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AACTGACCATGGAGTCTTGTT	0.363000													6	32					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94649796	94649796	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:94649796G>A	ENST00000260526.6	-	19	2340	c.2158C>T	c.(2158-2160)Caa>Taa	p.Q720*	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	720	Rho-GAP.			Q -> L (in Ref. 1; AAB81012).	Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCCAAAGCTTGACACAATTTT	0.303000													13	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179439073	179439073	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:179439073C>T	ENST00000589042.1	-	326	72010	c.71786G>A	c.(71785-71787)gGa>gAa	p.G23929E	TTN_ENST00000342175.6_Missense_Mutation_p.G15056E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G22288E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G14989E|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G14864E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G21361E|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22288	Ig-like 120.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTGGTTTTCCAGGTGGGTC	0.428000													40	80					0	0	1	0	0
HIST3H3	8290	broad.mit.edu	37	1	228612627	228612627	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:228612627C>G	ENST00000366696.1	-	1	399	c.400G>C	c.(400-402)Gag>Cag	p.E134Q		NM_003493.2	NP_003484.1	Q16695	H31T_HUMAN	histone cluster 3, H3	134					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(1)|lung(2)|prostate(2)|skin(1)	6		Prostate(94;0.0724)				TAGGCCCGCTCCCCGCGGATA	0.592000													51	78					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103950001	103950001	+	Missense_Mutation	SNP	C	C	T	rs137880778		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:103950001C>T	ENST00000394785.3	-	11	1926	c.1295G>A	c.(1294-1296)cGa>cAa	p.R432Q	SLC9B2_ENST00000362026.3_Missense_Mutation_p.R432Q|SLC9B2_ENST00000503103.1_Intron|SLC9B2_ENST00000503230.1_Missense_Mutation_p.R375Q|SLC9B2_ENST00000339611.4_Intron	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	432					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										AGTCAAAATTCGTATCAATAC	0.343000													11	39					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237955551	237955551	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:237955551C>A	ENST00000366574.2	+	94	14027	c.13710C>A	c.(13708-13710)ccC>ccA	p.P4570P	RYR2_ENST00000542537.1_Silent_p.P4554P|RYR2_ENST00000360064.6_Silent_p.P4576P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4570					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACATGGAGCCCACGTTGCGTA	0.463000													29	35					6.53348e-20	9.12289e-20	1	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24884930	24884930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:24884930C>A	ENST00000396432.2	-	18	4006	c.3520G>T	c.(3520-3522)Gaa>Taa	p.E1174*	ARHGAP21_ENST00000320481.6_Nonsense_Mutation_p.E961*	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1173	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						AGACCTCTTTCTTCAACTAAT	0.313000													8	9					0.0381472	0.0388102	1	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79058083	79058083	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:79058083C>G	ENST00000388820.4	-	19	4380	c.4170G>C	c.(4168-4170)gaG>gaC	p.E1390D		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1390					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCGGCTGGGTCTCAGGGACTC	0.682000													7	55					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650132	93650132	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:93650132G>C	ENST00000375754.4	+	12	1831	c.1683G>C	c.(1681-1683)ttG>ttC	p.L561F	SYK_ENST00000375751.4_Missense_Mutation_p.L538F|SYK_ENST00000375746.1_Missense_Mutation_p.L561F|SYK_ENST00000375747.1_Missense_Mutation_p.L538F	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	561	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						TTGGAGTGTTGATGTGGGAAG	0.498000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								64	161					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164174	139164174	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:139164174G>T	ENST00000395297.1	-	13	2714	c.2544C>A	c.(2542-2544)ccC>ccA	p.P848P		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	848										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTTTCCCTTTGGGGATGTCTA	0.483000										HNSCC(54;0.14)			10	75					1.58986e-06	1.77924e-06	1	1	0
DNAJC6	9829	broad.mit.edu	37	1	65858334	65858334	+	Silent	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:65858334A>C	ENST00000395325.3	+	12	1675	c.1518A>C	c.(1516-1518)gcA>gcC	p.A506A	DNAJC6_ENST00000371069.4_Silent_p.A563A|DNAJC6_ENST00000263441.7_Silent_p.A493A	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	506	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						AAGGGTCTGCAATGAGTAACA	0.592000													8	45					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113267624	113267624	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:113267624G>T	ENST00000297405.5	-	62	10139	c.9895C>A	c.(9895-9897)Caa>Aaa	p.Q3299K	CSMD3_ENST00000352409.3_Missense_Mutation_p.Q3229K|CSMD3_ENST00000455883.2_Missense_Mutation_p.Q3130K|CSMD3_ENST00000343508.3_Missense_Mutation_p.Q3259K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3299	Sushi 26.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTTTTTCCTTGGGCAGGTATA	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	33					8.10497e-08	9.30299e-08	1	1	0
NPTX2	4885	broad.mit.edu	37	7	98254278	98254278	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:98254278C>A	ENST00000265634.3	+	3	853	c.688C>A	c.(688-690)Cca>Aca	p.P230T		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	230	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GGTGTCCCTCCCACTCCGCAC	0.602000													43	357					1.21353e-23	1.77596e-23	1	1	0
SPATA6	54558	broad.mit.edu	37	1	48877206	48877206	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:48877206C>A	ENST00000371847.3	-	5	499	c.335G>T	c.(334-336)gGt>gTt	p.G112V	SPATA6_ENST00000396199.3_Missense_Mutation_p.G40V|SPATA6_ENST00000463938.1_5'UTR|SPATA6_ENST00000371843.3_Missense_Mutation_p.G112V	NM_019073.2	NP_061946.1	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6	112					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				breast(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	21						TTGGTTTGGACCCGGAAACAT	0.388000													17	54					2.94398e-08	3.38937e-08	1	1	0
ANGEL1	23357	broad.mit.edu	37	14	77257081	77257081	+	Silent	SNP	C	C	A	rs144966408	byFrequency	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:77257081C>A	ENST00000251089.2	-	9	1837	c.1725G>T	c.(1723-1725)acG>acT	p.T575T	ANGEL1_ENST00000557179.1_Silent_p.T140T	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	575										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TATATACTGACGTCAGGTGGA	0.468000													7	36					0.000157383	0.000170611	1	1	0
PROL1	58503	broad.mit.edu	37	4	71275205	71275205	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:71275205G>A	ENST00000399575.2	+	3	334	c.160G>A	c.(160-162)Gac>Aac	p.D54N	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	54	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				ACCTCCCTATGACTCAAGACT	0.498000													36	99					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063982	48063982	+	Nonstop_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:48063982G>T	ENST00000316364.5	+	19	3661	c.3222G>T	c.(3220-3222)taG>taT	p.*1074Y	SEMA6D_ENST00000536845.2_Nonstop_Mutation_p.*1074Y|SEMA6D_ENST00000558014.1_Nonstop_Mutation_p.*1012Y|SEMA6D_ENST00000354744.4_Nonstop_Mutation_p.*1018Y|SEMA6D_ENST00000558816.1_3'UTR|SEMA6D_ENST00000358066.4_Nonstop_Mutation_p.*1012Y|SEMA6D_ENST00000537942.1_Nonstop_Mutation_p.*1012Y|SEMA6D_ENST00000389433.2_Nonstop_Mutation_p.*1055Y|SEMA6D_ENST00000389428.3_Nonstop_Mutation_p.*999Y|SEMA6D_ENST00000389432.2_Nonstop_Mutation_p.*1031Y|SEMA6D_ENST00000355997.3_3'UTR	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0					axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACACATACTAGGCCTCAAGTG	0.453000													44	213					1.81118e-26	2.66083e-26	1	1	0
NES	10763	broad.mit.edu	37	1	156642865	156642865	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156642865A>G	ENST00000368223.3	-	4	1247	c.1115T>C	c.(1114-1116)cTt>cCt	p.L372P		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	372	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGGTTCTTAAGAAAGGCTGG	0.607000													30	183					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4317667	4317667	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:4317667G>T	ENST00000337872.4	+	7	1712	c.1591G>T	c.(1591-1593)Ggg>Tgg	p.G531W	ZBTB49_ENST00000538529.1_Missense_Mutation_p.G14W|ZBTB49_ENST00000355834.3_Intron	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	531					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						TCGGCACACGGGGGAGCGGCC	0.507000													24	75					2.12542e-12	2.65154e-12	1	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140750492	140750492	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140750492C>A	ENST00000576222.1	+	1	662	c.531C>A	c.(529-531)caC>caA	p.H177Q	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGATCCGCACTTCTCTTTGA	0.537000													93	235					1.16775e-40	1.79165e-40	1	1	0
CHRM3	1131	broad.mit.edu	37	1	240070926	240070926	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:240070926C>A	ENST00000255380.4	+	5	954	c.175C>A	c.(175-177)Cct>Act	p.P59T		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	59					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CACCGATGACCCTCTGGGAGG	0.557000													16	145					8.81451e-21	1.25615e-20	1	1	0
SNTG1	54212	broad.mit.edu	37	8	51465635	51465635	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:51465635G>T	ENST00000522124.1	+	12	1367	c.706G>T	c.(706-708)Gtg>Ttg	p.V236L	SNTG1_ENST00000518864.1_Missense_Mutation_p.V236L|SNTG1_ENST00000517473.1_Missense_Mutation_p.V236L|SNTG1_ENST00000276467.5_Missense_Mutation_p.V236L	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	236					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AGTCATTGCTGTGGATGGGGT	0.428000													19	125					2.70639e-06	3.01547e-06	1	1	0
DMBX1	127343	broad.mit.edu	37	1	46972693	46972693	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:46972693A>G	ENST00000371956.4	+	1	26	c.11A>G	c.(10-12)tAc>tGc	p.Y4C	DMBX1_ENST00000360032.3_Missense_Mutation_p.Y4C	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	4	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					ATGCAGCACTACGGGGTGAAC	0.637000													20	178					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862986	10862986	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:10862986C>T	ENST00000559480.1	+	0	282																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GGGACACATCCATGAGCACAG	0.507000													56	755					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3230722	3230722	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:3230722G>A	ENST00000355072.5	+	59	8240	c.8095G>A	c.(8095-8097)Gag>Aag	p.E2699K	HTT_ENST00000513806.1_3'UTR	NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2699					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCTGATCAGTGAGGTGGTCAG	0.597000													25	72					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358367	57358367	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:57358367A>G	ENST00000518770.1	-	3	299	c.146T>C	c.(145-147)gTt>gCt	p.V49A	PENK_ENST00000451791.2_Intron|PENK_ENST00000314922.3_Intron|PENK_ENST00000523051.1_Intron|RP11-17A4.2_ENST00000518662.1_RNA			P01210	PENK_HUMAN	proenkephalin	47					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCCGCGCGCAACACTCACCAG	0.687000													26	161					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28305242	28305242	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:28305242C>A	ENST00000284987.5	-	5	1932	c.1811G>T	c.(1810-1812)cGc>cTc	p.R604L	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	604	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGTGCAGTAGCGTCCGTTGTT	0.562000													6	43					0.0215528	0.0220156	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129807677	129807677	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:129807677C>A	ENST00000421865.2	+	56	7857	c.7808C>A	c.(7807-7809)gCa>gAa	p.A2603E		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2603	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCCACAGGGGCACGAACAATG	0.453000													33	68					6.05902e-23	8.79945e-23	1	1	0
MYH3	4621	broad.mit.edu	37	17	10543528	10543528	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:10543528T>A	ENST00000583535.1	-	22	2554	c.2467A>T	c.(2467-2469)Atg>Ttg	p.M823L	MYH3_ENST00000226209.7_Missense_Mutation_p.M823L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	823					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TTGACGTTCATGAATGAGCGA	0.473000													16	48					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107076856	107076856	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:107076856C>T	ENST00000539449.1	-	1	517	c.41G>A	c.(40-42)tGc>tAc	p.C14Y	RTN4IP1_ENST00000369063.3_Missense_Mutation_p.C14Y			Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	14						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AACCGCAGTGCATGCATTTCT	0.433000													25	44					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214819977	214819977	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:214819977C>T	ENST00000366955.3	+	13	7232	c.7064C>T	c.(7063-7065)gCa>gTa	p.A2355V		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2451	2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CAAGAGCATGCAGCTCTTGAG	0.438000													3	47					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30554589	30554589	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:30554589C>A	ENST00000383096.3	-	22	2627	c.2445G>T	c.(2443-2445)gtG>gtT	p.V815V	CCDC178_ENST00000579947.1_Silent_p.V815V|CCDC178_ENST00000403303.1_Silent_p.V815V|CCDC178_ENST00000402325.1_Silent_p.V765V|CCDC178_ENST00000579916.1_Silent_p.V135V|CCDC178_ENST00000581852.1_Silent_p.V20V|CCDC178_ENST00000300227.8_Silent_p.V777V|CCDC178_ENST00000406524.2_Silent_p.V839V|CCDC178_ENST00000583930.1_Silent_p.V839V					coiled-coil domain containing 178									p.V777V(2)|p.V815V(2)									TGAAGAGGACCACCAGTTTGA	0.512000													10	54					6.40141e-05	7.00931e-05	1	1	0
NHS	4810	broad.mit.edu	37	X	17743882	17743882	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:17743882G>T	ENST00000380060.3	+	6	1931	c.1593G>T	c.(1591-1593)ccG>ccT	p.P531P	NHS_ENST00000398097.3_Silent_p.P375P	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	531						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CAAGCAGCCCGAGTGCCCAGG	0.542000													8	69					0.000157383	0.000170611	1	1	0
TCFL5	10732	broad.mit.edu	37	20	61485407	61485407	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:61485407C>T	ENST00000335351.3	-	5	1433	c.1341G>A	c.(1339-1341)ctG>ctA	p.L447L	TCFL5_ENST00000217162.5_Silent_p.L399L	NM_006602.2	NP_006593.2	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 (basic helix-loop-helix)	447	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|urinary_tract(1)	9	Breast(26;5.68e-08)					GGATGTATTTCAGGAATGCTG	0.433000													13	112					0	0	1	0	0
FCHO2	115548	broad.mit.edu	37	5	72285274	72285274	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:72285274A>T	ENST00000430046.2	+	3	262	c.146A>T	c.(145-147)tAc>tTc	p.Y49F	FCHO2_ENST00000287761.6_Missense_Mutation_p.Y49F|FCHO2_ENST00000512348.1_Missense_Mutation_p.Y49F|FCHO2_ENST00000341845.6_Missense_Mutation_p.Y49F	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	49	FCH.									cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		GAGGAGGCATACTCCAGGTCA	0.323000													4	11					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5170040	5170040	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:5170040G>A	ENST00000282908.5	+	3	545	c.123G>A	c.(121-123)caG>caA	p.Q41Q	STK32B_ENST00000510398.1_5'UTR|STK32B_ENST00000512636.1_5'UTR	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	41	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						GCATCGTGCAGAAGCGAGACA	0.473000													4	43					0	0	1	0	0
SLC2A3	6515	broad.mit.edu	37	12	8078467	8078467	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:8078467C>A	ENST00000075120.7	-	7	1179	c.939G>T	c.(937-939)gtG>gtT	p.V313V		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	313					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		TAGTATTAACCACACCCGCGC	0.423000													24	108					1.39806e-14	1.80939e-14	1	1	0
C16orf46	123775	broad.mit.edu	37	16	81095214	81095214	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:81095214C>A	ENST00000378611.4	-	3	855	c.740G>T	c.(739-741)gGg>gTg	p.G247V	C16orf46_ENST00000299578.5_Missense_Mutation_p.G247V|RP11-303E16.8_ENST00000564536.1_RNA	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	247										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						AGCCACACACCCATCCTTTTC	0.468000													56	192					5.86059e-21	8.38329e-21	1	1	0
ROBO1	6091	broad.mit.edu	37	3	78667098	78667098	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:78667098A>G	ENST00000436010.2	-	25	4849	c.3852T>C	c.(3850-3852)gaT>gaC	p.D1284D	ROBO1_ENST00000467549.1_Silent_p.D1223D|ROBO1_ENST00000464233.1_Silent_p.D1323D|ROBO1_ENST00000495273.1_Silent_p.D1278D			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1323					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GCGCATCCGTATCCATATCTG	0.552000													6	69					0	0	1	0	0
CD300LD	100131439	broad.mit.edu	37	17	72584744	72584744	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:72584744C>G	ENST00000375352.1	-	2	365	c.285G>C	c.(283-285)gaG>gaC	p.E95D	C17orf77_ENST00000392620.1_Intron	NM_001115152.1	NP_001108624.1	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d	95	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			large_intestine(1)|lung(2)|prostate(1)|stomach(1)	5						TTTTGAGATTCTCCATGGTCA	0.433000													30	233					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169995788	169995788	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:169995788A>G	ENST00000263816.3	-	74	13646	c.13361T>C	c.(13360-13362)cTt>cCt	p.L4454P		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4454					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGCAGGCAAAAGGGAGCCGGT	0.468000													3	100					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132257844	132257844	+	RNA	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:132257844G>C	ENST00000438378.2	+	0	567					NR_026922.1																						GTCCTCGTTGGCTGGAACCTC	0.567000													21	43					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382720	22382720	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:22382720T>A	ENST00000328795.4	+	1	339	c.248T>A	c.(247-249)gTg>gAg	p.V83E	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AGGATGTTGGTGGACTTCCTC	0.512000													20	311					0	0	1	0	0
SLC30A10	55532	broad.mit.edu	37	1	220101698	220101698	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:220101698C>A	ENST00000366926.3	-	1	246	c.85G>T	c.(85-87)Ggc>Tgc	p.G29C	SLC30A10_ENST00000536992.1_Missense_Mutation_p.G29C|SLC30A10_ENST00000536446.1_Intron	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	29					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		CCCAGGTAGCCGGAGACCAGC	0.662000													4	45					2.0095e-06	2.24227e-06	1	1	0
SERPINI2	5276	broad.mit.edu	37	3	167189533	167189533	+	Silent	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:167189533T>G	ENST00000476257.1	-	3	388	c.90A>C	c.(88-90)gcA>gcC	p.A30A	SERPINI2_ENST00000461846.1_Silent_p.A30A|SERPINI2_ENST00000465031.1_5'UTR|SERPINI2_ENST00000264677.4_Silent_p.A30A|SERPINI2_ENST00000471111.1_Silent_p.A30A			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	30					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						AAAGATCCACTGCAAATTCGG	0.388000													9	103					0	0	1	0	0
TP53INP2	58476	broad.mit.edu	37	20	33298102	33298102	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:33298102C>T	ENST00000374810.3	+	5	1043	c.654C>T	c.(652-654)ttC>ttT	p.F218F	TP53INP2_ENST00000374809.2_Silent_p.F218F|NCOA6_ENST00000593786.1_Intron	NM_021202.1	NP_067025.1	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	218						nucleus				endometrium(1)|urinary_tract(1)	2						AGCGCCAGTTCAACTACTGAG	0.682000													6	24					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142004848	142004848	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:142004848C>A	ENST00000389484.3	-	5	1510	c.539G>T	c.(538-540)tGt>tTt	p.C180F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	180	EGF-like 2; calcium-binding (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCTTCCACACAACTGCAAGT	0.388000										TSP Lung(27;0.18)			14	136					1.15088e-07	1.31504e-07	1	1	0
MC4R	4160	broad.mit.edu	37	18	58039136	58039136	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:58039136A>G	ENST00000299766.3	-	1	865	c.447T>C	c.(445-447)ttT>ttC	p.F149F		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	149					feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				AGAAGATAGTAAAGTACCTGT	0.428000													13	115					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15761599	15761599	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:15761599C>T	ENST00000378076.3	-	1	525	c.172G>A	c.(172-174)Ggc>Agc	p.G58S		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	58					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						ACGGCGTAGCCGAAGTAGCTG	0.687000													6	13					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2817322	2817322	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:2817322G>T	ENST00000301740.8	+	11	7342	c.6793G>T	c.(6793-6795)Gca>Tca	p.A2265S		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2265	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GCCAGCTGCAGCAGCGGCCAT	0.632000													64	155					1.41408e-17	1.92164e-17	1	1	0
TNS3	64759	broad.mit.edu	37	7	47343038	47343038	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:47343038C>A	ENST00000398879.1	-	22	3333	c.2967G>T	c.(2965-2967)ccG>ccT	p.P989P	TNS3_ENST00000355730.3_Silent_p.P749P|TNS3_ENST00000311160.9_Silent_p.P989P			Q68CZ2	TENS3_HUMAN	tensin 3	989						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GCTCTGACGGCGGGAAGCAGG	0.672000													13	29					0.000308642	0.000331747	1	1	0
EPB41L1	2036	broad.mit.edu	37	20	34809854	34809854	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:34809854C>T	ENST00000338074.2	+	20	2669	c.2508C>T	c.(2506-2508)gtC>gtT	p.V836V	EPB41L1_ENST00000373950.2_Silent_p.V727V|EPB41L1_ENST00000441639.1_Silent_p.V734V|EPB41L1_ENST00000202028.5_Silent_p.V734V|EPB41L1_ENST00000373941.1_Silent_p.V835V|EPB41L1_ENST00000373946.3_Silent_p.V656V	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	836	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					ATGAAGATGTCGATCAAGACC	0.517000													22	148					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57134023	57134023	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:57134023C>A	ENST00000439986.4	-	5	538	c.501G>T	c.(499-501)cgG>cgT	p.R167R	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	167	EGF-like; calcium-binding (Potential).				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				CATCATCTTCCCGGATGTAGC	0.473000													30	232					1.36161e-19	1.88741e-19	1	1	0
INA	9118	broad.mit.edu	37	10	105037100	105037100	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:105037100C>A	ENST00000369849.4	+	1	181	c.132C>A	c.(130-132)tcC>tcA	p.S44S		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	44	Head.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AGTCGCTGTCCCGCAGCAATG	0.751000													4	11					0.014758	0.0151563	1	1	0
SLIT3	6586	broad.mit.edu	37	5	168310311	168310311	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:168310311G>T	ENST00000519560.1	-	5	863	c.444C>A	c.(442-444)atC>atA	p.I148I	SLIT3_ENST00000332966.8_Silent_p.I148I|SLIT3_ENST00000404867.3_Silent_p.I148I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	148					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTTCCTCGGGATCCCCTGGA	0.473000													11	68					3.27435e-08	3.76402e-08	1	1	0
ZNF615	284370	broad.mit.edu	37	19	52496644	52496644	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:52496644T>A	ENST00000602063.1	-	6	2034	c.1685A>T	c.(1684-1686)cAt>cTt	p.H562L	ZNF615_ENST00000598071.1_Missense_Mutation_p.H573L|ZNF615_ENST00000594083.1_Missense_Mutation_p.H573L|ZNF615_ENST00000376716.5_Missense_Mutation_p.H562L|ZNF615_ENST00000391795.3_Missense_Mutation_p.H567L			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTCTCCTGTATGAGTGCGCCG	0.448000													51	143					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29957549	29957549	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:29957549C>A	ENST00000216121.7	-	6	779	c.525G>T	c.(523-525)gaG>gaT	p.E175D		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	175								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						TGGGCTGTGGCTCATTCCAGA	0.587000													35	79					1.22674e-20	1.73846e-20	1	1	0
EPHB4	2050	broad.mit.edu	37	7	100402834	100402834	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:100402834C>A	ENST00000358173.3	-	16	3256	c.2788G>T	c.(2788-2790)Gcc>Tcc	p.A930S	EPHB4_ENST00000360620.3_Intron	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	930	SAM.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					AAGCCAGCGGCTGCGAAACTT	0.602000													14	22					9.16793e-09	1.06354e-08	1	1	0
HOXC11	3227	broad.mit.edu	37	12	54369110	54369110	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:54369110G>A	ENST00000243082.4	+	2	946	c.832G>A	c.(832-834)Gaa>Aaa	p.E278K	HOXC11_ENST00000546378.1_Silent_p.V276V	NM_014212.3	NP_055027.1	O43248	HXC11_HUMAN	homeobox C11	0					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						ACCGACAAGTGAAAATTTGGT	0.493000			T	NUP98	AML								22	108					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100170098	100170098	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:100170098C>A	ENST00000524871.1	+	20	2880	c.2590C>A	c.(2590-2592)Caa>Aaa	p.Q864K	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Missense_Mutation_p.Q864K|CNTN5_ENST00000279463.3_Missense_Mutation_p.Q864K|CNTN5_ENST00000418526.2_Missense_Mutation_p.Q790K|CNTN5_ENST00000528682.1_Missense_Mutation_p.Q864K	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	864	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCCTTTTAGTCAAATTGTGGT	0.338000													8	55					0.00829132	0.00860804	1	1	0
PLXNA2	5362	broad.mit.edu	37	1	208390490	208390490	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:208390490G>A	ENST00000367033.3	-	2	1535	c.778C>T	c.(778-780)Ccc>Tcc	p.P260S		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	260	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGGGTCTCGGGCTGGACAGTG	0.557000													31	252					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21450829	21450829	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:21450829G>A	ENST00000425654.2	+	3	808	c.328G>A	c.(328-330)Ggc>Agc	p.G110S	CNKSR2_ENST00000279451.4_Missense_Mutation_p.G110S|CNKSR2_ENST00000543067.1_Missense_Mutation_p.G110S|CNKSR2_ENST00000379510.3_Missense_Mutation_p.G110S	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	110	CRIC.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						GAGAAGGAGTGGCCATTATGA	0.438000													30	98					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11325286	11325286	+	Silent	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:11325286C>G	ENST00000294618.7	-	33	4157	c.4146G>C	c.(4144-4146)ggG>ggC	p.G1382G	CTC-510F12.2_ENST00000588634.1_RNA|DOCK6_ENST00000319867.7_Silent_p.G721G	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1382					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						TTGCCAGGTTCCCTTCCACCA	0.577000													10	57					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61388157	61388157	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:61388157C>A	ENST00000544088.1	+	0	773				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000536691.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				TTGAGCTGCCCTACGTTAACA	0.358000													3	12					0.004672	0.0048704	1	1	0
DIP2C	22982	broad.mit.edu	37	10	403803	403803	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:403803G>A	ENST00000280886.6	-	23	2956	c.2869C>T	c.(2869-2871)Ctg>Ttg	p.L957L	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Silent_p.L278L	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	957						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		ATCTGACCCAGGTCTCTGCCA	0.587000													17	109					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005685	118005685	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:118005685C>A	ENST00000310754.4	-	1	1051	c.865G>T	c.(865-867)Gga>Tga	p.G289*		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	289	TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane		p.G289R(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TTTACATTTCCAGTAAGGGCA	0.443000													32	45					2.75727e-19	3.80814e-19	1	1	0
PCOLCE	5118	broad.mit.edu	37	7	100200090	100200090	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:100200090C>A	ENST00000223061.5	+	1	291	c.11C>A	c.(10-12)gCa>gAa	p.A4E	PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA|PCOLCE_ENST00000496269.1_3'UTR	NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	4					multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ATGCTGCCTGCAGCCACAGCC	0.657000													41	64					8.20599e-20	1.14373e-19	1	1	0
VENTX	27287	broad.mit.edu	37	10	135053272	135053272	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:135053272C>A	ENST00000325980.9	+	2	845	c.334C>A	c.(334-336)Cac>Aac	p.H112N		NM_014468.2	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	112					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		CGTCTTCCAGCACCACCAGTA	0.647000													14	48					6.49762e-13	8.20015e-13	1	1	0
BAAT	570	broad.mit.edu	37	9	104124900	104124900	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:104124900G>C	ENST00000259407.2	-	4	1175	c.1067C>G	c.(1066-1068)tCt>tGt	p.S356C	BAAT_ENST00000395051.3_Missense_Mutation_p.S356C	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	356					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CCCAGGGTAAGATAGCAGGGT	0.512000													20	66					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18823127	18823127	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:18823127C>A	ENST00000446231.2	-	62	11276	c.10864G>T	c.(10864-10866)Ggc>Tgc	p.G3622C	SMG1_ENST00000389467.3_Missense_Mutation_p.G3623C|RP11-1035H13.2_ENST00000569096.1_RNA			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3622					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACATCTCGGCCCTCTAACTTG	0.448000													86	595					8.64784e-51	1.34033e-50	1	1	0
NLGN3	54413	broad.mit.edu	37	X	70384154	70384154	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:70384154C>T	ENST00000374051.3	+	5	1151	c.829C>T	c.(829-831)Ctc>Ttc	p.L277F	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.L257F|NLGN3_ENST00000358741.3_Missense_Mutation_p.L297F	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	297					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					CGTCAGCCTCCTCACGTTGTC	0.612000													23	52					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6921856	6921856	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:6921856G>T	ENST00000312053.4	+	14	1790	c.1753G>T	c.(1753-1755)Gca>Tca	p.A585S	EMR1_ENST00000381407.5_Missense_Mutation_p.A444S|EMR1_ENST00000381404.4_Missense_Mutation_p.A533S|EMR1_ENST00000250572.8_Missense_Mutation_p.A585S|EMR1_ENST00000450315.3_Missense_Mutation_p.A408S	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	585	GPS.|Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TAATCAGATGGCAAATCTTGC	0.483000													37	81					1.22674e-20	1.73846e-20	1	1	0
TTN	7273	broad.mit.edu	37	2	179588708	179588708	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:179588708G>C	ENST00000589042.1	-	73	21502	c.21278C>G	c.(21277-21279)aCa>aGa	p.T7093R	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.T6776R|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T5849R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6776	Ig-like 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTGAAAATGTGGTTTGGTA	0.428000													40	45					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709081	128709081	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:128709081C>A	ENST00000392665.2	-	2	1202	c.1058G>T	c.(1057-1059)gGc>gTc	p.G353V	KCNJ1_ENST00000392666.1_Missense_Mutation_p.G353V|KCNJ1_ENST00000324036.3_Missense_Mutation_p.G353V|KCNJ1_ENST00000440599.2_Missense_Mutation_p.G353V|KCNJ1_ENST00000392664.2_Missense_Mutation_p.G372V	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	372					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GTTGTCATAGCCTCTCTTCAT	0.428000													19	45					1.50039e-11	1.85658e-11	1	1	0
RYR2	6262	broad.mit.edu	37	1	237777744	237777744	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:237777744T>C	ENST00000366574.2	+	37	5633	c.5316T>C	c.(5314-5316)agT>agC	p.S1772S	RYR2_ENST00000542537.1_Silent_p.S1756S|RYR2_ENST00000360064.6_Silent_p.S1770S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1772	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAAGCATTAGTAATGAATGTT	0.493000													24	155					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35679275	35679275	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:35679275C>T	ENST00000378357.4	+	7	1105	c.1001C>T	c.(1000-1002)cCg>cTg	p.P334L	CA9_ENST00000493245.1_3'UTR	NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	334	Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGACTACACCGCCCTGTGCC	0.572000													46	448					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733452	50733452	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:50733452G>T	ENST00000300589.2	+	2	232	c.127G>T	c.(127-129)Gag>Tag	p.E43*	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	43	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CCAGCTGGTCGAGCTGCTGGT	0.602000													41	257					2.6238e-40	4.01753e-40	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113243687	113243687	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:113243687C>A	ENST00000401783.2	-	12	2536	c.2200G>T	c.(2200-2202)Gta>Tta	p.V734L	SVEP1_ENST00000302728.8_Missense_Mutation_p.V734L|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374461.1_Missense_Mutation_p.V711L|SVEP1_ENST00000374469.1_Missense_Mutation_p.V711L	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	734	Sushi 4.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCCCCATTTACAGGTGTGAAT	0.363000													3	12					0.004672	0.0048704	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80835381	80835381	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:80835381A>C	ENST00000466387.1	+	21	3092	c.2368A>C	c.(2368-2370)Aat>Cat	p.N790H	CTNNA2_ENST00000343114.3_Missense_Mutation_p.N469H|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000402739.4_Missense_Mutation_p.N790H|CTNNA2_ENST00000541047.1_Missense_Mutation_p.N790H|CTNNA2_ENST00000361291.4_Missense_Mutation_p.N824H|CTNNA2_ENST00000496558.1_Missense_Mutation_p.N790H|AC008067.2_ENST00000430876.1_RNA			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	790					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CCATCAGCTTAATATCTGCAG	0.433000													46	60					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100124084	100124084	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:100124084T>A	ENST00000375202.2	+	41	5044	c.3692T>A	c.(3691-3693)cTg>cAg	p.L1231Q	CCDC180_ENST00000529487.1_Missense_Mutation_p.L1231Q|CCDC180_ENST00000357054.1_Missense_Mutation_p.L1202Q|CCDC180_ENST00000395220.1_3'UTR|RP11-23J9.4_ENST00000534123.1_RNA					coiled-coil domain containing 180																		GAGGCCAAGCTGGACGTGGTC	0.587000													24	66					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44828147	44828147	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:44828147C>A	ENST00000372262.3	-	7	1738	c.1338G>T	c.(1336-1338)gcG>gcT	p.A446A	CDH22_ENST00000537909.1_Silent_p.A446A	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	446	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CGCCTGTGTCCGCATCGATAT	0.637000													5	45					0.00116845	0.00123842	1	1	0
MROH5	389690	broad.mit.edu	37	8	142487573	142487573	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:142487573C>T	ENST00000430863.1	-	0	1455					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGCTCCTTCTCCATCAAAACC	0.667000													18	36					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46320459	46320459	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:46320459C>T	ENST00000465950.1	-	1	3289	c.2080G>A	c.(2080-2082)Gat>Aat	p.D694N	SCAF11_ENST00000549162.1_Missense_Mutation_p.D817N|SCAF11_ENST00000369367.3_Missense_Mutation_p.D1009N|SCAF11_ENST00000419565.2_Missense_Mutation_p.D1009N			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1009					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GAATTTGGATCATCAGCATCT	0.373000													32	153					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103870809	103870809	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:103870809C>A	ENST00000302251.5	-	2	732	c.281G>T	c.(280-282)gGa>gTa	p.G94V	PDGFD_ENST00000393158.2_Missense_Mutation_p.G100V	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	100	CUB.				positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TTCCTCTAATCCAAACTGATT	0.403000													17	127					4.63292e-17	6.2401e-17	1	1	0
ZMYM6	9204	broad.mit.edu	37	1	35485166	35485166	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:35485166T>C	ENST00000357182.4	-	4	443	c.216A>G	c.(214-216)gcA>gcG	p.A72A	ZMYM6_ENST00000373333.1_Silent_p.A72A|ZMYM6_ENST00000487874.1_Silent_p.A72A|ZMYM6_ENST00000373340.2_Silent_p.A72A|ZMYM6_ENST00000317538.5_Silent_p.A72A|ZMYM6_ENST00000493328.1_Intron	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	72					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGCCAGATGATGCAAAAGAAA	0.373000													10	44					0	0	1	0	0
CYP51A1	1595	broad.mit.edu	37	7	91743097	91743097	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:91743097G>A	ENST00000003100.8	-	10	1577	c.1412C>T	c.(1411-1413)aCt>aTt	p.T471I	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Missense_Mutation_p.T366I	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	465					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	ACGAAGCATAGTGGACCAAAT	0.333000													16	95					0	0	1	0	0
TRBV6-7	28600	broad.mit.edu	37	7	142143686	142143686	+	RNA	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:142143686G>A	ENST00000390373.2	-	0	309																											ACAGAAGTCTGAGAGGGAGCA	0.537000													29	167					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5929152	5929152	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:5929152C>T	ENST00000399933.3	-	6	2389	c.2390G>A	c.(2389-2391)tGg>tAg	p.W797*	KIAA2026_ENST00000381461.2_Nonsense_Mutation_p.W767*	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	797										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCGATGATACCATTTTCCCTA	0.299000													11	22					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77396129	77396129	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:77396129C>G	ENST00000282849.5	-	7	1507	c.1089G>C	c.(1087-1089)caG>caC	p.Q363H		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	363	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TATTCAGAGACTGGTCTGCAT	0.393000													19	69					0	0	1	0	0
TSPAN10	83882	broad.mit.edu	37	17	79612590	79612590	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:79612590C>T	ENST00000328585.4	+	0	699				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GCTTCCTCCTCGACCAAGTCC	0.667000													8	22					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238832	3238832	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:3238832A>T	ENST00000217939.6	-	5	5048	c.4894T>A	c.(4894-4896)Tac>Aac	p.Y1632N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1632						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTTACAAAGTATCTGGAAGCG	0.473000													40	115					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100348424	100348424	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:100348424C>T	ENST00000542585.1	+	0	1574				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCGGGGAGTCCCCCGATTCC	0.617000													6	35					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17603353	17603353	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:17603353C>A	ENST00000375460.3	+	13	1577	c.1537C>A	c.(1537-1539)Ctg>Atg	p.L513M		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	513					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GAGGGCCCTCCTGTTCCAGGG	0.607000													9	15					1.58986e-06	1.77924e-06	1	1	0
TTC30B	150737	broad.mit.edu	37	2	178416760	178416760	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:178416760G>A	ENST00000408939.2	-	1	982	c.732C>T	c.(730-732)gtC>gtT	p.V244V		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	244					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			TCTGATGGAGGACTAAGGTGT	0.522000													20	141					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216019257	216019257	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:216019257C>A	ENST00000366943.2	-	45	9350	c.8964G>T	c.(8962-8964)aaG>aaT	p.K2988N	USH2A_ENST00000307340.3_Missense_Mutation_p.K2988N			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2988	Fibronectin type-III 16.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTGTTTGGCTTTAGGTGGC	0.433000										HNSCC(13;0.011)			5	71					0.217242	0.218102	1	1	0
ZFP69	339559	broad.mit.edu	37	1	40961689	40961689	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:40961689T>C	ENST00000372706.1	+	6	2545	c.1539T>C	c.(1537-1539)caT>caC	p.H513H	ZFP69_ENST00000372705.3_Silent_p.H513H|RP11-656D10.3_ENST00000450713.1_RNA					ZFP69 zinc finger protein																		TTAGTCGACATCATGAAATAC	0.373000													13	44					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156920071	156920071	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:156920071C>A	ENST00000257527.4	-	16	1896	c.1818G>T	c.(1816-1818)cgG>cgT	p.R606R	ADAM19_ENST00000517905.1_Silent_p.R606R|ADAM19_ENST00000394020.1_Silent_p.R608R|ADAM19_ENST00000430702.2_Silent_p.R339R	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	606	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGTGGGTGCCCCGGCACTGGA	0.607000													27	141					9.65021e-13	1.21586e-12	1	1	0
KCNQ3	3786	broad.mit.edu	37	8	133492653	133492653	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:133492653C>A	ENST00000388996.4	-	1	547	c.127G>T	c.(127-129)Gtg>Ttg	p.V43L	KCNQ3_ENST00000519445.1_Missense_Mutation_p.V43L	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	43					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCCAGCCCCACTTTCCGCTCC	0.801000													4	16					2.0095e-06	2.24227e-06	1	1	0
AGPAT9	84803	broad.mit.edu	37	4	84518669	84518669	+	Splice_Site	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:84518669G>T	ENST00000395226.2	+	10	1214		c.e10+1		AGPAT9_ENST00000264409.4_Splice_Site	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9						phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				TGCAATTAAGGTAAAACAGAT	0.323000													16	24					2.35188e-11	2.90078e-11	1	1	0
NLK	51701	broad.mit.edu	37	17	26488217	26488217	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:26488217C>G	ENST00000407008.3	+	4	1394	c.676C>G	c.(676-678)Cta>Gta	p.L226V		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	226	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GCAGAGTGACCTACATAAAAT	0.393000													4	57					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133984078	133984078	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:133984078C>A	ENST00000220616.4	+	33	6055	c.6015C>A	c.(6013-6015)tgC>tgA	p.C2005*	TG_ENST00000519543.1_Nonsense_Mutation_p.C159*|TG_ENST00000377869.1_Nonsense_Mutation_p.C1948*|TG_ENST00000542445.1_Nonsense_Mutation_p.C375*	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2005					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CGGACCCATGCTGCACTGGCT	0.478000													13	107					0.00152264	0.00160935	1	1	0
RYR1	6261	broad.mit.edu	37	19	38939110	38939110	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:38939110G>T	ENST00000355481.4	+	10	1047	c.916G>T	c.(916-918)Gct>Tct	p.A306S	RYR1_ENST00000359596.3_Missense_Mutation_p.A306S|RYR1_ENST00000360985.3_Missense_Mutation_p.A306S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	306	MIR 4.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGCCAGCAAGGCTCACACCAA	0.662000													37	259					1.89013e-27	2.79842e-27	1	1	0
GJA10	84694	broad.mit.edu	37	6	90605169	90605169	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:90605169C>A	ENST00000369352.1	+	1	982	c.982C>A	c.(982-984)Cat>Aat	p.H328N		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	328					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GAAGGATCAGCATAGCGGACA	0.517000											OREG0004443	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=CX62|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	28	39					1.13719e-10	1.37584e-10	1	1	0
SLC38A10	124565	broad.mit.edu	37	17	79244796	79244796	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:79244796C>A	ENST00000374759.3	-	10	1436	c.1053G>T	c.(1051-1053)gcG>gcT	p.A351A	SLC38A10_ENST00000546352.1_5'UTR|SLC38A10_ENST00000288439.5_Silent_p.A351A	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	351					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TTCCCATGGTCGCTCCTGTGA	0.587000													10	47					7.93312e-07	8.95713e-07	1	1	0
CRYGB	1419	broad.mit.edu	37	2	209007452	209007452	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:209007452C>A	ENST00000260988.4	-	3	485	c.438G>T	c.(436-438)ctG>ctT	p.L146L		NM_005210.3	NP_005201.2	P07316	CRGB_HUMAN	crystallin, gamma B	146	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)	14				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		CCGGCCTCAGCAGATACTGCC	0.522000													41	172					2.13384e-23	3.1168e-23	1	1	0
PCDH15	65217	broad.mit.edu	37	10	55582532	55582532	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:55582532G>T	ENST00000361849.3	-	34	5354	c.4960C>A	c.(4960-4962)Cag>Aag	p.Q1654K	PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.Q1583K|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395433.1_Missense_Mutation_p.Q1629K|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.Q1612K|PCDH15_ENST00000320301.6_Missense_Mutation_p.Q1652K|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.Q1649K|PCDH15_ENST00000395445.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1652					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GATTTCAACTGTTCTGTTCCT	0.413000										HNSCC(58;0.16)			37	84					4.92203e-23	7.16188e-23	1	1	0
ABL2	27	broad.mit.edu	37	1	179090749	179090749	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:179090749A>C	ENST00000502732.1	-	5	1144	c.941T>G	c.(940-942)gTt>gGt	p.V314G	ABL2_ENST00000408940.3_Missense_Mutation_p.V278G|ABL2_ENST00000367623.4_Missense_Mutation_p.V293G|ABL2_ENST00000392043.3_Missense_Mutation_p.V293G|ABL2_ENST00000344730.3_Missense_Mutation_p.V299G|ABL2_ENST00000511413.1_Missense_Mutation_p.V314G|ABL2_ENST00000507173.1_Missense_Mutation_p.V293G|ABL2_ENST00000512653.1_Missense_Mutation_p.V299G|ABL2_ENST00000504405.1_Missense_Mutation_p.V278G	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	314	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTTCACAGCAACTGTAAGGCT	0.433000			T	ETV6	AML								143	101					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53878065	53878065	+	Splice_Site	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:53878065A>G	ENST00000471389.1	+	4	973		c.e4-1		FTO_ENST00000394647.3_Splice_Site	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated						DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						CTCTTTTGGCAGGCCCTGAAG	0.348000													17	75					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47292802	47292802	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:47292802G>T	ENST00000396220.1	-	14	1616	c.1594C>A	c.(1594-1596)Cgt>Agt	p.R532S	PREX1_ENST00000371941.3_Missense_Mutation_p.R532S			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	532	DEP 2.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGGTAATCACGGTCTCTGTGG	0.627000													39	139					3.54561e-26	5.19886e-26	1	1	0
ZNF318	24149	broad.mit.edu	37	6	43305982	43305982	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:43305982C>T	ENST00000361428.2	-	10	5831	c.5754G>A	c.(5752-5754)gaG>gaA	p.E1918E	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1918					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTAGCCCCTCCTCACTAACAA	0.423000													36	75					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195391062	195391062	+	RNA	SNP	C	C	G	rs2688562	by1000genomes	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:195391062C>G	ENST00000445430.1	+	0	588																											GCAGGCCCATCGGTGCTGCTG	0.537000													3	78					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641626	55641626	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:55641626C>T	ENST00000343870.4	+	1	645	c.555C>T	c.(553-555)ctC>ctT	p.L185L		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						TACTGCAGCTCTCTTGCACAG	0.413000													21	73					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371408	240371408	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:240371408C>T	ENST00000319653.9	+	5	3526	c.3296C>T	c.(3295-3297)cCg>cTg	p.P1099L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1099	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATACCCCCTCCGCCCCCTCTA	0.731000													31	244					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16882916	16882916	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:16882916T>C	ENST00000377833.4	-	61	9859	c.9794A>G	c.(9793-9795)gAa>gGa	p.E3265G		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3265	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATTAAATCCTTCCCTCTCTAA	0.373000													11	76					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7755155	7755155	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:7755155G>T	ENST00000358415.4	+	5	540	c.374G>T	c.(373-375)gGc>gTc	p.G125V	ITIH2_ENST00000480387.1_3'UTR|ITIH2_ENST00000379587.4_Missense_Mutation_p.G114V	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	125	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ACTGTGGACGGCAAGACATTT	0.478000													5	50					0.217242	0.218102	1	1	0
GAS2	2620	broad.mit.edu	37	11	22747863	22747863	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:22747863G>A	ENST00000454584.2	+	4	598	c.293G>A	c.(292-294)tGc>tAc	p.C98Y	GAS2_ENST00000433790.1_Missense_Mutation_p.C98Y|GAS2_ENST00000278187.3_Missense_Mutation_p.C98Y	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	98	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AAGATCCCATGCAAAACCAGT	0.388000													11	100					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38800294	38800294	+	Silent	SNP	C	C	A	rs55851227		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:38800294C>A	ENST00000308979.2	-	4	432	c.159G>T	c.(157-159)tcG>tcT	p.S53S	TLR1_ENST00000502213.2_Silent_p.S53S	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	53					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						TATAATTTTGCGATATATTTA	0.313000													16	68					3.45872e-05	3.7981e-05	1	1	0
C1orf173	127254	broad.mit.edu	37	1	75037804	75037804	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:75037804G>A	ENST00000326665.5	-	14	3808	c.3590C>T	c.(3589-3591)tCc>tTc	p.S1197F	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1197	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTCCCTGCTGGACAGCTCTTC	0.557000													37	230					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110853231	110853231	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:110853231G>A	ENST00000375820.4	-	20	1211	c.1090C>T	c.(1090-1092)Cca>Tca	p.P364S	COL4A1_ENST00000543140.1_Missense_Mutation_p.P364S	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	364	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGTAGTCCTGGGAAACCTGAA	0.423000													10	63					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404480	124404480	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:124404480C>G	ENST00000303921.2	-	1	1201	c.551G>C	c.(550-552)aGg>aCg	p.R184T		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	184						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CCCGGCTCTCCTTGGCCAGTA	0.627000													63	102					0	0	1	0	0
WDR38	401551	broad.mit.edu	37	9	127618016	127618016	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:127618016G>A	ENST00000373574.1	+	3	350	c.294G>A	c.(292-294)ctG>ctA	p.L98L		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	98										breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						CGAAGTGTCTGCGGGTCCTGA	0.617000											OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	124					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96762234	96762234	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:96762234G>T	ENST00000295266.4	+	1	996	c.933G>T	c.(931-933)aaG>aaT	p.K311N		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	311					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TAAGAAGTAAGAGGGATCCTA	0.418000													25	39					4.59853e-10	5.47649e-10	1	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762083	130762083	+	Silent	SNP	G	G	A	rs143602233		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:130762083G>A	ENST00000392429.1	+	2	2894	c.516G>A	c.(514-516)acG>acA	p.T172T	TMEM200A_ENST00000545622.1_Silent_p.T172T|TMEM200A_ENST00000296978.3_Silent_p.T172T	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	172						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ACATTCACACGCTAAGAATCA	0.418000													7	90					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69646754	69646754	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:69646754G>C	ENST00000453994.2	+	8	956	c.595G>C	c.(595-597)Gtc>Ctc	p.V199L	GDPD2_ENST00000374382.3_Missense_Mutation_p.V199L|GDPD2_ENST00000472623.1_3'UTR|GDPD2_ENST00000538649.1_Missense_Mutation_p.V120L|GDPD2_ENST00000536730.1_Missense_Mutation_p.V120L	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	199					glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					TTTTGGAGTTGTCCTGGTCAT	0.577000													32	28					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701681	30701681	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:30701681G>C	ENST00000256246.2	-	1	4927	c.4853C>G	c.(4852-4854)tCt>tGt	p.S1618C		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1618										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CAAAATTTGAGATAGATTAGC	0.373000													10	34					0	0	1	0	0
UAP1	6675	broad.mit.edu	37	1	162560177	162560177	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:162560177C>G	ENST00000271469.3	+	8	1536	c.1234C>G	c.(1234-1236)Cag>Gag	p.Q412E	UAP1_ENST00000367924.1_Missense_Mutation_p.Q412E|UAP1_ENST00000367925.1_Missense_Mutation_p.Q412E|UAP1_ENST00000367926.4_Missense_Mutation_p.Q412E			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1	412					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TGCTGATAGTCAGAATGGGAA	0.418000													21	168					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75648464	75648464	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:75648464G>A	ENST00000565683.1	-	25	3045	c.3034C>T	c.(3034-3036)Cag>Tag	p.Q1012*	MAN2C1_ENST00000267978.5_Nonsense_Mutation_p.Q995*|MAN2C1_ENST00000563622.1_Nonsense_Mutation_p.Q896*|MAN2C1_ENST00000569482.1_Nonsense_Mutation_p.Q972*	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	995					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						ATGGCCTCCTGAACCGGCAGC	0.682000													13	51					0	0	1	0	0
TIMP3	7078	broad.mit.edu	37	22	33255251	33255251	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:33255251C>T	ENST00000266085.6	+	5	824	c.523C>T	c.(523-525)Cct>Tct	p.P175S	SYN3_ENST00000332840.5_Intron|SYN3_ENST00000358763.2_Intron	NM_000362.4	NP_000353.1	P35625	TIMP3_HUMAN	TIMP metallopeptidase inhibitor 3	175	Mediates interaction with EFEMP1.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(2)|large_intestine(3)|lung(1)|urinary_tract(1)	7						TTTCGGTTACCCTGGCTACCA	0.532000													58	67					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458167	45458167	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:45458167C>A	ENST00000548424.1	+	0	448																											TCCCGACATTCTGGACGAGAG	0.468000													23	28					1.64293e-13	2.09777e-13	1	1	0
SRCAP	10847	broad.mit.edu	37	16	30748940	30748940	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:30748940C>G	ENST00000262518.4	+	34	7964	c.7579C>G	c.(7579-7581)Ctc>Gtc	p.L2527V	SRCAP_ENST00000395059.2_Missense_Mutation_p.L2465V|SRCAP_ENST00000344771.4_Missense_Mutation_p.L2369V	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2527	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TTCCTCTCCTCTCTTGCTTGG	0.582000													33	207					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22835968	22835968	+	Splice_Site	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:22835968G>A	ENST00000283645.4	+	2	329	c.200_splice	c.e2+1	p.G67_splice	TUBGCP5_ENST00000453949.2_Splice_Site_p.G67_splice	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	67					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		AACAATCGAAGGGTAAGTCAG	0.289000													32	68					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19661758	19661758	+	Silent	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:19661758A>C	ENST00000438132.3	+	25	2398	c.2350A>C	c.(2350-2352)Aga>Cga	p.R784R	C16orf62_ENST00000544275.1_3'UTR|C16orf62_ENST00000417362.2_Intron|C16orf62_ENST00000543152.1_Silent_p.R444R|C16orf62_ENST00000542263.1_Intron|C16orf62_ENST00000448695.1_Silent_p.R545R|C16orf62_ENST00000251143.5_Silent_p.R695R	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	695						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						AAATCATTCCAGAAAGACAGC	0.388000													17	148					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918114	43918114	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:43918114C>A	ENST00000336086.6	-	4	3055	c.819G>T	c.(817-819)tgG>tgT	p.W273C	URGCP_ENST00000443736.1_Missense_Mutation_p.W273C|URGCP_ENST00000453200.1_Missense_Mutation_p.W316C|URGCP_ENST00000223341.7_Missense_Mutation_p.W273C|URGCP_ENST00000402306.3_Missense_Mutation_p.W307C|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000447717.3_Missense_Mutation_p.W273C|RP5-1165K10.1_ENST00000603700.1_Intron			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	316					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TGGGAAAAAACCAGGAAATTT	0.557000													30	49					1.836e-18	2.51747e-18	1	1	0
CLRN1	7401	broad.mit.edu	37	3	150690371	150690371	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:150690371G>A	ENST00000327047.1	-	1	415	c.125C>T	c.(124-126)aCg>aTg	p.T42M	RP11-166N6.2_ENST00000469268.1_RNA|CLRN1-AS1_ENST00000476886.1_RNA|CLRN1_ENST00000328863.4_Missense_Mutation_p.T42M	NM_174878.2	NP_777367.1	P58418	CLRN1_HUMAN	clarin 1	42					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CAGAGCTCCCGTTTTGCAGAG	0.547000													18	167					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28734754	28734754	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:28734754T>A	ENST00000257197.3	-	5	871	c.610A>T	c.(610-612)Aaa>Taa	p.K204*	DSC1_ENST00000257198.5_Nonsense_Mutation_p.K204*|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	204	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TGTTCATATTTCTCACGGTCA	0.333000													9	23					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247695610	247695610	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:247695610G>A	ENST00000366487.3	-	2	565	c.204C>T	c.(202-204)ccC>ccT	p.P68P	GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000463359.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	68			P -> S (in dbSNP:rs6657127).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGTCCAGGAAGGGGAGGTTGG	0.507000													10	82					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064610	78064610	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:78064610C>G	ENST00000299642.4	+	3	578	c.493C>G	c.(493-495)Cgt>Ggt	p.R165G	CLEC3A_ENST00000575655.1_Missense_Mutation_p.R156G|RP11-281J9.2_ENST00000563114.1_RNA|CLEC3A_ENST00000565808.1_3'UTR	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	156	C-type lectin.				skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						CAACTGGGACCGTGCACAGCC	0.532000													26	145					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49672049	49672049	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:49672049G>T	ENST00000561648.1	-	4	1067	c.1014C>A	c.(1012-1014)gtC>gtA	p.V338V	ZNF423_ENST00000567169.1_Silent_p.V221V|ZNF423_ENST00000563137.2_Silent_p.V278V|ZNF423_ENST00000535559.1_Silent_p.V221V|ZNF423_ENST00000262383.2_Silent_p.V338V|ZNF423_ENST00000562871.1_Silent_p.V278V|ZNF423_ENST00000562520.1_Silent_p.V278V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	338					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GGTGGCAGTAGACACCTTCCA	0.617000													11	40					5.16669e-11	6.33148e-11	1	1	0
OR51T1	401665	broad.mit.edu	37	11	4903927	4903927	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:4903927C>A	ENST00000380378.1	+	1	879	c.879C>A	c.(877-879)ctC>ctA	p.L293L	OR51T1_ENST00000322049.1_Silent_p.L266L|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACACCGCCTCTTCCACTCCA	0.473000													23	75					1.80694e-10	2.1689e-10	1	1	0
CPED1	79974	broad.mit.edu	37	7	120911417	120911417	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:120911417C>A	ENST00000310396.5	+	22	3268	c.2801C>A	c.(2800-2802)aCa>aAa	p.T934K		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1									p.T934K(1)									GTAGTTGACACATTCACTATA	0.363000													36	62					7.04047e-22	1.01282e-21	1	1	0
ZNF124	7678	broad.mit.edu	37	1	247320487	247320487	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:247320487C>G	ENST00000340684.6	-	4	389	c.251G>C	c.(250-252)gGa>gCa	p.G84A	ZNF124_ENST00000491848.1_5'UTR|ZNF124_ENST00000472531.1_Intron|ZNF124_ENST00000543802.2_Missense_Mutation_p.G146A|ZNF124_ENST00000491356.1_Intron	NM_003431.2	NP_003422.2	Q15973	ZN124_HUMAN	zinc finger protein 124	146	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(2)	14	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			GGGTTTCTCTCCAGTGTGATT	0.363000													7	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179431615	179431615	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:179431615C>T	ENST00000589042.1	-	326	79468	c.79244G>A	c.(79243-79245)gGa>gAa	p.G26415E	TTN_ENST00000342175.6_Missense_Mutation_p.G17542E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G24774E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G17475E|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G17350E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G23847E|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24774	Fibronectin type-III 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATCTCACTTCCACCATCACT	0.418000													13	46					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:7578457C>A	ENST00000420246.2	-	5	605	c.473G>T	c.(472-474)cGc>cTc	p.R158L	TP53_ENST00000269305.4_Missense_Mutation_p.R158L|TP53_ENST00000445888.2_Missense_Mutation_p.R158L|TP53_ENST00000455263.2_Missense_Mutation_p.R158L|TP53_ENST00000413465.2_Missense_Mutation_p.R158L|TP53_ENST00000359597.4_Missense_Mutation_p.R158L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	158	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> C (in sporadic cancers; somatic mutation).|R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158L(77)|p.R158H(74)|p.R158P(9)|p.R65L(8)|p.0?(8)|p.R26L(8)|p.R158fs(6)|p.R158fs*11(6)|p.R65H(5)|p.R26H(5)|p.R158_A159insX(4)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R26fs(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.R158C(1)|p.V157_I162delVRAMAI(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	70					1.00953e-15	1.32686e-15	1	1	0
SP1	6667	broad.mit.edu	37	12	53803152	53803152	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:53803152G>A	ENST00000426431.2	+	5	1890	c.1830G>A	c.(1828-1830)tcG>tcA	p.S610S	SP1_ENST00000327443.4_Silent_p.S617S	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	617	Transactivation domain C (highly charged).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		TCAGGGGCTCGGGGGATCCTG	0.468000													6	28					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44980768	44980768	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:44980768G>A	ENST00000372227.1	-	8	1299	c.759C>T	c.(757-759)gcC>gcT	p.A253A	SLC35C2_ENST00000372229.1_Silent_p.A120A|SLC35C2_ENST00000543605.1_Silent_p.A282A|SLC35C2_ENST00000317734.8_Silent_p.A232A|SLC35C2_ENST00000493599.1_5'UTR|SLC35C2_ENST00000243896.2_Silent_p.A253A|SLC35C2_ENST00000372230.5_Silent_p.A253A			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	253					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				CCAAACCAAAGGCGAGAATCC	0.552000													16	136					0	0	1	0	0
NSG1	27065	broad.mit.edu	37	4	4411334	4411334	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:4411334T>G	ENST00000421177.2	+	8	2272	c.281T>G	c.(280-282)cTc>cGc	p.L94R	NSG1_ENST00000506380.1_Missense_Mutation_p.L94R|NSG1_ENST00000505246.1_Missense_Mutation_p.L94R|NSG1_ENST00000513555.1_Missense_Mutation_p.L94R|NSG1_ENST00000433139.2_Missense_Mutation_p.L94R|NSG1_ENST00000504171.1_Missense_Mutation_p.L55R|NSG1_ENST00000397958.1_Missense_Mutation_p.L94R																							CTGGCCTTCCTCACCTGCGTC	0.607000													13	82					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66480270	66480270	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:66480270T>C	ENST00000256447.4	-	3	558	c.401A>G	c.(400-402)cAa>cGa	p.Q134R		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	134					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TATTCCCGTTTGGATTAAGAA	0.408000													28	151					0	0	1	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188227	70188227	+	Silent	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:70188227G>C	ENST00000320256.4	-	1	1170	c.594C>G	c.(592-594)ctC>ctG	p.L198L		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	198					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						TCTTCCCCTTGAGATAGTAGC	0.602000													19	85					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113465005	113465005	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:113465005G>T	ENST00000487903.1	+	5	494	c.406G>T	c.(406-408)Ggc>Tgc	p.G136C	ATP11A_ENST00000283558.8_Missense_Mutation_p.G136C|ATP11A_ENST00000375645.3_Missense_Mutation_p.G136C|ATP11A_ENST00000375630.2_Missense_Mutation_p.G136C			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	136					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CATTCAGCACGGCAAGCTCGT	0.433000													16	123					1.33834e-09	1.58148e-09	1	1	0
CNTN1	1272	broad.mit.edu	37	12	41318400	41318400	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:41318400G>C	ENST00000551295.2	+	6	559	c.442G>C	c.(442-444)Gta>Cta	p.V148L	CNTN1_ENST00000547702.1_Missense_Mutation_p.V148L|CNTN1_ENST00000347616.1_Missense_Mutation_p.V148L|CNTN1_ENST00000547849.1_Missense_Mutation_p.V148L|CNTN1_ENST00000348761.2_Missense_Mutation_p.V137L|CNTN1_ENST00000360099.3_Missense_Mutation_p.V148L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	148	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGAGGTCAGAGTAAAAGAAGG	0.398000													5	60					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52709852	52709852	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:52709852C>T	ENST00000293670.3	-	7	1149	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	363	Coil 2.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGGCCGCCTCACCCTGCTGC	0.587000													11	83					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774827	122774827	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:122774827A>C	ENST00000227349.2	+	3	836	c.539A>C	c.(538-540)cAg>cCg	p.Q180P	C11orf63_ENST00000531316.1_Missense_Mutation_p.Q180P|C11orf63_ENST00000307257.6_Missense_Mutation_p.Q180P	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	180										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAAGGCGAGCAGAAAGAGAGT	0.522000													12	67					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39380361	39380361	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:39380361G>T	ENST00000249396.7	-	7	701	c.400C>A	c.(400-402)Ctc>Atc	p.L134I	SIRT2_ENST00000392081.2_Missense_Mutation_p.L97I|SIRT2_ENST00000358931.5_Missense_Mutation_p.L134I	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	134	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			TCCTTGGCGAGGGCGAAGAAG	0.607000													10	97					3.86212e-05	4.23498e-05	1	1	0
OCA2	4948	broad.mit.edu	37	15	28263617	28263617	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:28263617C>T	ENST00000354638.3	-	7	888	c.733G>A	c.(733-735)Ggg>Agg	p.G245R	OCA2_ENST00000353809.5_Missense_Mutation_p.G245R|OCA2_ENST00000382996.2_Missense_Mutation_p.G245R	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	245					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TCTTCCCTCCCAGGACGACTC	0.617000									Oculocutaneous Albinism				7	27					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161603	90161603	+	RNA	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:90161603G>T	ENST00000564451.1	+	0	956				TUBB8P7_ENST00000567960.1_RNA																							CGGAGCTGATGGAGTCAGTGA	0.612000													11	54					2.32078e-09	2.72549e-09	1	1	0
OR2M3	127062	broad.mit.edu	37	1	248366867	248366867	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:248366867C>A	ENST00000456743.1	+	1	536	c.498C>A	c.(496-498)ttC>ttA	p.F166L		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATTTTCCTTCTCCTACTGTG	0.433000													49	290					3.19069e-20	4.47991e-20	1	1	0
CLEC16A	23274	broad.mit.edu	37	16	11114086	11114086	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:11114086C>T	ENST00000409790.1	+	12	1570	c.1340C>T	c.(1339-1341)tCa>tTa	p.S447L	CLEC16A_ENST00000409552.3_Missense_Mutation_p.S429L	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	447								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AGCAAGCTCTCAGAGCTGGCC	0.562000													13	51					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195391111	195391111	+	RNA	SNP	T	T	C	rs150842970	by1000genomes	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:195391111T>C	ENST00000445430.1	+	0	637																											TTGCACACCTTATATGGGAGG	0.597000													3	30					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52619331	52619331	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:52619331G>C	ENST00000600228.1	-	4	1347	c.1086C>G	c.(1084-1086)ttC>ttG	p.F362L	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		ATCTATGTCTGAATGCCTTGC	0.408000													30	280					0	0	1	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124759	26124759	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:26124759G>A	ENST00000602637.1	+	1	329	c.299G>A	c.(298-300)cGg>cAg	p.R100Q	HIST1H2AC_ENST00000377791.2_Missense_Mutation_p.R100Q			Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	100					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(5)	12						CTGCTAGGCCGGGTGACCATT	0.602000													53	171					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50188718	50188718	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:50188718C>A	ENST00000335999.6	-	8	3126	c.2925G>T	c.(2923-2925)gcG>gcT	p.A975A		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	971										central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						GCAGGTCTTCCGCCTTGGCCA	0.697000													4	5					0.0293803	0.029931	1	1	0
APOB	338	broad.mit.edu	37	2	21239511	21239511	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:21239511C>A	ENST00000233242.1	-	21	3259	c.3132G>T	c.(3130-3132)caG>caT	p.Q1044H		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1044					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAGCCTCAGTCTGCTTCGCAC	0.478000													15	67					9.16793e-09	1.06354e-08	1	1	0
IGHV6-1	28385	broad.mit.edu	37	14	106405889	106405889	+	RNA	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:106405889G>T	ENST00000390593.2	-	0	136																											ACCAGTCCTGGACCTGACTGC	0.552000													6	20					0.0215528	0.0220156	1	1	0
ABHD1	84696	broad.mit.edu	37	2	27353440	27353440	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:27353440C>T	ENST00000316470.4	+	9	1160	c.1046C>T	c.(1045-1047)gCg>gTg	p.A349V		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	349						integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTACGTTGCGCTGCTCATC	0.617000													32	226					0	0	1	0	0
NFX1	4799	broad.mit.edu	37	9	33301376	33301376	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:33301376G>C	ENST00000379540.3	+	3	1211	c.1149G>C	c.(1147-1149)ttG>ttC	p.L383F	NFX1_ENST00000318524.6_Missense_Mutation_p.L383F|NFX1_ENST00000379521.4_Missense_Mutation_p.L383F	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	383					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TGTTTCATTTGAACTGCATAA	0.418000													15	220					0	0	1	0	0
ZNF80	7634	broad.mit.edu	37	3	113955274	113955274	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:113955274G>A	ENST00000482457.2	-	1	1151	c.648C>T	c.(646-648)ccC>ccT	p.P216P		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	216						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TGCACTCGTAGGGCTTTCCTG	0.493000													35	70					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50832032	50832032	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:50832032A>C	ENST00000442544.2	+	13	2612	c.1996A>C	c.(1996-1998)Acc>Ccc	p.T666P	DCC_ENST00000412726.1_Missense_Mutation_p.T514P|DCC_ENST00000581580.1_Missense_Mutation_p.T321P	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	666	Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAGAAAGACGACCCGCAGGGG	0.433000													14	126					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	367187	367187	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:367187G>T	ENST00000342640.4	-	7	833	c.791C>A	c.(790-792)cCc>cAc	p.P264H	THEG_ENST00000346878.2_Missense_Mutation_p.P240H	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	264					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCGAGCTGGGGACTGCCAT	0.577000													18	57					1.01871e-10	1.2384e-10	1	1	0
C7orf60	154743	broad.mit.edu	37	7	112555405	112555405	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:112555405C>A	ENST00000297145.4	-	2	423	c.258G>T	c.(256-258)tgG>tgT	p.W86C	C7orf60_ENST00000485446.1_5'UTR	NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	86										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						AAGTTTTTGCCCAATGATTAT	0.363000													18	106					8.81451e-21	1.25615e-20	1	1	0
MOV10	4343	broad.mit.edu	37	1	113242427	113242427	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:113242427C>T	ENST00000369644.1	+	19	3565	c.2536C>T	c.(2536-2538)Ccc>Tcc	p.P846S	MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000413052.2_Missense_Mutation_p.P902S|MOV10_ENST00000357443.2_Missense_Mutation_p.P902S|MOV10_ENST00000369645.1_Missense_Mutation_p.P902S			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	902					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CCTTAAGAACCCCAAGGTTTG	0.537000													78	156					0	0	1	0	0
DPM1	8813	broad.mit.edu	37	20	49574937	49574937	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:49574937G>A	ENST00000371582.4	-	1	155	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F	DPM1_ENST00000371588.5_Missense_Mutation_p.L42F|DPM1_ENST00000371583.5_Missense_Mutation_p.L42F|DPM1_ENST00000466152.1_5'UTR			O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	42					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	7						CACACGATGAGCGGCAGGTTC	0.597000													20	58					0	0	1	0	0
ZNF398	57541	broad.mit.edu	37	7	148876884	148876884	+	Silent	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:148876884A>G	ENST00000420008.2	+	6	2195	c.1407A>G	c.(1405-1407)ggA>ggG	p.G469G	ZNF398_ENST00000491174.1_Silent_p.G469G|ZNF398_ENST00000540950.1_Silent_p.G645G|ZNF398_ENST00000426851.2_Silent_p.G469G|ZNF398_ENST00000475153.1_Silent_p.G640G|ZNF398_ENST00000335901.4_Silent_p.G469G|ZNF398_ENST00000483892.1_Silent_p.G469G	NM_170686.2	NP_733787.1	Q8TD17	ZN398_HUMAN	zinc finger protein 398	640					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GTGGAGGGGGAGTTTTGTAAA	0.517000													37	30					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659281	50659281	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:50659281G>A	ENST00000439308.2	-	16	3999	c.3507C>T	c.(3505-3507)atC>atT	p.I1169I	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Silent_p.I1169I	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1169	9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCCCCAAGCTGATGCTGGCAT	0.632000													22	132					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649371	136649371	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:136649371C>T	ENST00000287538.5	+	1	1071	c.521C>T	c.(520-522)tCg>tTg	p.S174L	ZIC3_ENST00000370606.3_Missense_Mutation_p.S174L	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	174					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					GGGCACCCGTCGCCCACAGGG	0.706000													16	45					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390996	197390996	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:197390996C>A	ENST00000367397.1	+	2	1039	c.181C>A	c.(181-183)Cct>Act	p.P61T	CRB1_ENST00000543483.1_3'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.P680T|CRB1_ENST00000367400.3_Missense_Mutation_p.P680T|CRB1_ENST00000535699.1_Missense_Mutation_p.P611T|CRB1_ENST00000544212.1_Missense_Mutation_p.P161T|CRB1_ENST00000367399.2_Missense_Mutation_p.P568T			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	680	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGAAAGCCAACCTTGTCAAAG	0.478000													13	168					0.000151284	0.000164703	1	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12884844	12884844	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:12884844C>G	ENST00000535591.1	-	4	1462	c.1267G>C	c.(1267-1269)Gac>Cac	p.D423H		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	423										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						AATGACCTGTCGCCATGGTCA	0.468000													96	162					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156533589	156533589	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:156533589G>A	ENST00000361170.2	-	6	475	c.465C>T	c.(463-465)gcC>gcT	p.A155A		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	155					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTATCTGAGGGGCCAATCCCA	0.542000													11	21					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26624938	26624938	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:26624938C>T	ENST00000288710.2	+	1	155	c.81C>T	c.(79-81)gtC>gtT	p.V27V		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		CGCCCTCGGTCCACTCCGACA	0.711000													5	43					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969325	47969325	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:47969325G>A	ENST00000236877.6	-	2	731	c.336C>T	c.(334-336)gcC>gcT	p.A112A	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	112					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TCTCACCGTTGGCCTTGGTGA	0.577000													19	55					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442728	138442728	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:138442728G>T	ENST00000344876.4	-	4	3249	c.2863C>A	c.(2863-2865)Cca>Aca	p.P955T	PCDH18_ENST00000511115.1_Missense_Mutation_p.P135T|PCDH18_ENST00000412923.2_Missense_Mutation_p.P954T|PCDH18_ENST00000510305.1_Missense_Mutation_p.P166T|PCDH18_ENST00000507846.1_Missense_Mutation_p.P734T	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	955	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GGTTGCGTTGGGAATTCTTCC	0.517000													34	161					6.29468e-14	8.10534e-14	1	1	0
CCBE1	147372	broad.mit.edu	37	18	57134024	57134024	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:57134024C>A	ENST00000439986.4	-	5	537	c.500G>T	c.(499-501)cGg>cTg	p.R167L	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	167	EGF-like; calcium-binding (Potential).				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				ATCATCTTCCCGGATGTAGCC	0.478000													30	233					1.36161e-19	1.88741e-19	1	1	0
CCDC170	80129	broad.mit.edu	37	6	151917628	151917628	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:151917628G>T	ENST00000367290.5	+	9	1715	c.1626G>T	c.(1624-1626)gtG>gtT	p.V542V	CCDC170_ENST00000239374.7_Silent_p.V542V			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	542																	AGAAGAAGGTGGAGAGGCTGC	0.547000													35	73					1.32136e-16	1.76413e-16	1	1	0
BRAF	673	broad.mit.edu	37	7	140481402	140481402	+	Missense_Mutation	SNP	C	C	G	rs121913358		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:140481402C>G	ENST00000288602.6	-	11	1466	c.1406G>C	c.(1405-1407)gGa>gCa	p.G469A		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	469	Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(13)|p.G469S(5)|p.G469E(5)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCC	0.373000	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				86	87					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105175030	105175030	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:105175030A>G	ENST00000392634.4	+	10	2022	c.1910A>G	c.(1909-1911)aAg>aGg	p.K637R	INF2_ENST00000330634.7_Missense_Mutation_p.K637R	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	637	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GATGCCAAGAAGAGCCTGAAC	0.612000											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	121					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1083821	1083821	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:1083821C>G	ENST00000441003.2	+	18	2380	c.2353C>G	c.(2353-2355)Cag>Gag	p.Q785E	MUC2_ENST00000359061.5_Missense_Mutation_p.Q785E	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	785						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCTCAGCTGCCAGACGCTGGC	0.687000													6	25					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46313322	46313322	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:46313322C>A	ENST00000359930.4	-	6	1592	c.741G>T	c.(739-741)acG>acT	p.T247T	CTD-2653D5.1_ENST00000526566.2_RNA|SULF2_ENST00000361612.4_Silent_p.T247T|SULF2_ENST00000467815.1_Silent_p.T247T|SULF2_ENST00000484875.1_Silent_p.T247T	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	247					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						TGTAGCTCGGCGTGCTGGTGG	0.632000													27	91					1.42033e-22	2.05489e-22	1	1	0
KIAA0895L	653319	broad.mit.edu	37	16	67213732	67213732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:67213732C>A	ENST00000290881.7	-	4	1626	c.700G>T	c.(700-702)Ggc>Tgc	p.G234C	KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000563902.1_Missense_Mutation_p.G234C|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.G234C			Q68EN5	K895L_HUMAN	KIAA0895-like	234										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						CCAGCGCAGCCCTCCTTCTGC	0.582000													18	101					3.51602e-12	4.36491e-12	1	1	0
MICAL3	57553	broad.mit.edu	37	22	18305787	18305787	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr22:18305787G>A	ENST00000441493.2	-	23	3585	c.3233C>T	c.(3232-3234)tCa>tTa	p.S1078L		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1078	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGCTGGTTCTGAGTCCACATC	0.572000													24	38					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839108	62839108	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:62839108G>A	ENST00000536311.1	+	7	923	c.559G>A	c.(559-561)Gcg>Acg	p.A187T	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Missense_Mutation_p.A187T			Q01538	MYT1_HUMAN	myelin transcription factor 1	187					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CTTGGGCCAGGCGGCCAAGCC	0.587000													20	72					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77894759	77894759	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:77894759C>T	ENST00000262198.4	+	4	1918	c.1463C>T	c.(1462-1464)cCt>cTt	p.P488L		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	488					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GGAGTTCTCCCTGTGGGCCAG	0.597000													23	118					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190234183	190234183	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:190234183C>G	ENST00000367462.3	-	4	661	c.430G>C	c.(430-432)Gag>Cag	p.E144Q	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.E42Q|RP11-547I7.1_ENST00000452178.1_RNA	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		144						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGTGACTCCTCTCCTGCATTA	0.373000													10	77					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125811216	125811216	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:125811216G>T	ENST00000299308.3	+	1	55	c.47G>T	c.(46-48)gGg>gTg	p.G16V	TMEM132B_ENST00000418253.2_Intron	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	16						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTCTGCACCGGGGGAGGTCGG	0.542000													9	32					4.36969e-10	5.21212e-10	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72830781	72830781	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:72830781G>A	ENST00000268489.5	-	9	6472	c.5800C>T	c.(5800-5802)Cca>Tca	p.P1934S	ZFHX3_ENST00000397992.5_Missense_Mutation_p.P1020S	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1934					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCAATGCGTGGAGGGAGCATG	0.542000													24	111					0	0	1	0	0
RPS5	6193	broad.mit.edu	37	19	58904809	58904809	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:58904809G>A	ENST00000596046.1	+	3	1251	c.402G>A	c.(400-402)gtG>gtA	p.V134V	RPS5_ENST00000598495.1_Silent_p.V155V|RPS5_ENST00000598098.1_Silent_p.V64V|RPS5_ENST00000196551.3_Silent_p.V134V|RPS5_ENST00000601521.1_Silent_p.V134V			P46782	RS5_HUMAN	ribosomal protein S5	134					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome			cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		CCGGGACTGTGAGACGACAGG	0.642000													45	115					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129518638	129518638	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:129518638G>C	ENST00000276218.2	-	1	873	c.784C>G	c.(784-786)Cgg>Ggg	p.R262G		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	262						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						CACAGGTACCGTTCCAGCACT	0.572000													64	67					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													3	100					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529805	80529805	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:80529805G>A	ENST00000295057.3	-	2	1796	c.1140C>T	c.(1138-1140)aaC>aaT	p.N380N	CTNNA2_ENST00000540488.1_Intron|LRRTM1_ENST00000409148.1_Silent_p.N380N|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000496558.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	380						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GATCACTGCGGTTGGTGACGG	0.716000										HNSCC(69;0.2)			4	26					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141763343	141763343	+	Silent	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:141763343A>T	ENST00000475668.2	+	36	4356	c.4302A>T	c.(4300-4302)ccA>ccT	p.P1434P	MGAM_ENST00000549489.2_Silent_p.P1434P			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1434	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGTTTCTCCAGGCTGCAGGG	0.493000													5	27					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42320588	42320588	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:42320588G>A	ENST00000342228.3	-	4	820	c.451C>T	c.(451-453)Cca>Tca	p.P151S	SLC20A2_ENST00000520262.1_Missense_Mutation_p.P151S|SLC20A2_ENST00000520179.1_Missense_Mutation_p.P151S	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	151					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GACAACAGTGGAGATATAAAC	0.299000													14	16					0	0	1	0	0
PHTF2	57157	broad.mit.edu	37	7	77572057	77572057	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:77572057C>T	ENST00000416283.2	+	14	1937	c.1811C>T	c.(1810-1812)tCt>tTt	p.S604F	PHTF2_ENST00000422959.2_Missense_Mutation_p.S604F|PHTF2_ENST00000275575.7_Missense_Mutation_p.S600F|PHTF2_ENST00000248550.7_Missense_Mutation_p.S638F|PHTF2_ENST00000307305.8_Missense_Mutation_p.S600F	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						ATAGTTTCATCTGCTTTCTTA	0.373000													9	33					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301854	120301854	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:120301854A>T	ENST00000369406.3	-	4	786	c.737T>A	c.(736-738)tTg>tAg	p.L246*	HMGCS2_ENST00000476640.1_Intron|HMGCS2_ENST00000544913.2_Nonsense_Mutation_p.L204*	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	246					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		CTCCGAGGCCAAATTTGGTTT	0.463000													12	80					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104307066	104307066	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr9:104307066G>C	ENST00000389120.3	+	6	736	c.646G>C	c.(646-648)Gaa>Caa	p.E216Q		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	216					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GATAGTGGAGGAAGCAGTGCA	0.413000													33	49					0	0	1	0	0
KDSR	2531	broad.mit.edu	37	18	60999136	60999136	+	Splice_Site	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:60999136T>A	ENST00000406396.3	-	10	1271		c.e10-2		KDSR_ENST00000589592.1_Splice_Site|KDSR_ENST00000326575.5_Splice_Site	NM_002035.2	NP_002026.1	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase						3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			endometrium(2)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	9						GGTGACCACCTGCAAGATAAA	0.413000													11	73					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52899793	52899793	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:52899793C>T	ENST00000354452.3	-	17	2207	c.1596G>A	c.(1594-1596)aaG>aaA	p.K532K	TCF4_ENST00000537856.3_Silent_p.K402K|TCF4_ENST00000564999.1_Silent_p.K532K|TCF4_ENST00000398339.1_Silent_p.K634K|TCF4_ENST00000457482.3_Silent_p.K372K|TCF4_ENST00000561831.3_Silent_p.K372K|TCF4_ENST00000543082.1_Silent_p.K490K|TCF4_ENST00000566279.1_Silent_p.K472K|TCF4_ENST00000537578.1_Silent_p.K508K|TCF4_ENST00000568673.1_Silent_p.K508K|TCF4_ENST00000561992.1_Silent_p.K402K|TCF4_ENST00000570287.2_Silent_p.K372K|TCF4_ENST00000567880.1_Silent_p.K472K|TCF4_ENST00000544241.2_Silent_p.K461K|TCF4_ENST00000540999.1_Silent_p.K508K|TCF4_ENST00000564228.1_Silent_p.K461K|TCF4_ENST00000566286.1_Silent_p.K529K|TCF4_ENST00000568740.1_Silent_p.K507K|TCF4_ENST00000564403.2_Silent_p.K538K|TCF4_ENST00000565018.2_Silent_p.K532K|TCF4_ENST00000570177.2_Silent_p.K402K|TCF4_ENST00000356073.4_Silent_p.K532K	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	532					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CATCTAATTTCTTGTCCTCCG	0.423000													11	83					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114619641	114619641	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:114619641C>T	ENST00000393486.1	+	4	888	c.298C>T	c.(298-300)Cac>Tac	p.H100Y	MDFIC_ENST00000257724.3_Missense_Mutation_p.H209Y	NM_001166345.1|NM_199072.4	NP_001159817.1|NP_951038.1	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	100					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						AAAGAACGGCCACACAGGTCT	0.473000													12	112					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46099341	46099341	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:46099341C>A	ENST00000295452.4	-	2	297	c.130G>T	c.(130-132)Gat>Tat	p.D44Y		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	44					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AAATCCTCATCATCTTCATCA	0.333000													12	102					0.00136819	0.00144812	1	1	0
SCN9A	6335	broad.mit.edu	37	2	167129195	167129195	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:167129195C>A	ENST00000375387.4	-	17	3408	c.3068G>T	c.(3067-3069)aGg>aTg	p.R1023M	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1011M|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1022M|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1023M			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1022						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTTATCTCCCTGGAAATCTT	0.333000													3	14					0.00024832	0.000268045	1	1	0
PSG3	5671	broad.mit.edu	37	19	43236970	43236970	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:43236970G>T	ENST00000327495.5	-	3	859	c.675C>A	c.(673-675)gcC>gcA	p.A225A	PSG3_ENST00000595140.1_Silent_p.A225A	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	225	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				CACTGCGGCTGGCACTCACTG	0.522000													78	612					2.18907e-53	3.39976e-53	1	1	0
SCAMP5	192683	broad.mit.edu	37	15	75310792	75310792	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:75310792G>A	ENST00000361900.6	+	7	636	c.429G>A	c.(427-429)acG>acA	p.T143T	SCAMP5_ENST00000568081.1_Silent_p.T76T|SCAMP5_ENST00000562212.1_Silent_p.T151T|SCAMP5_ENST00000545456.1_Silent_p.T72T|SCAMP5_ENST00000425597.3_Silent_p.T143T	NM_001178111.1	NP_001171582.1	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	143					exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	5						TCTTCGGAACGAACATTGGCT	0.592000													39	238					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169758994	169758994	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:169758994A>C	ENST00000375363.3	+	2	350	c.258A>C	c.(256-258)gaA>gaC	p.E86D	G6PC2_ENST00000429379.2_Missense_Mutation_p.E86D|G6PC2_ENST00000421979.1_Intron|SPC25_ENST00000472216.2_Intron	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	86					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						GGGTCCAAGAAACTCAGATTT	0.368000													19	77					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212091	90212091	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:90212091C>A	ENST00000390277.2	+	0	280																											AGAAACCTGGCCAGGCTCCCA	0.597000													37	49					8.69298e-16	1.14651e-15	1	1	0
FLNA	2316	broad.mit.edu	37	X	153589708	153589708	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:153589708G>A	ENST00000422373.1	-	21	3423	c.3175C>T	c.(3175-3177)Ctg>Ttg	p.L1059L	FLNA_ENST00000369850.3_Silent_p.L1059L|FLNA_ENST00000344736.4_Silent_p.L1059L|FLNA_ENST00000360319.4_Silent_p.L1059L	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1059					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACAGCTTCCAGAGGAAAGGGG	0.627000													12	34					0	0	1	0	0
TM6SF2	53345	broad.mit.edu	37	19	19375646	19375646	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:19375646G>C	ENST00000389363.4	-	10	1033	c.961C>G	c.(961-963)Cgc>Ggc	p.R321G	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	321						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			AAGGGTGTGCGCAGGTGCATG	0.607000													13	68					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875304	247875304	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:247875304A>T	ENST00000302084.2	-	1	801	c.754T>A	c.(754-756)Tat>Aat	p.Y252N	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GTGGACCCATACCAAATGAGC	0.532000													13	121					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77526571	77526571	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:77526571G>A	ENST00000461745.1	+	3	1295	c.395G>A	c.(394-396)cGa>cAa	p.R132Q	ROBO2_ENST00000332191.8_Missense_Mutation_p.R132Q|ROBO2_ENST00000487694.3_Missense_Mutation_p.R148Q	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	132					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCAGTGTTACGAGATGACTTC	0.468000													47	91					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34028512	34028512	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:34028512A>C	ENST00000389232.4	+	49	7571	c.7501A>C	c.(7501-7503)Aaa>Caa	p.K2501Q	RYR3_ENST00000415757.3_Missense_Mutation_p.K2501Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2501	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAATACTGCAAAATGCCTCT	0.408000													3	21					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411535	43411535	+	Silent	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:43411535T>A	ENST00000310826.5	-	3	2853	c.2670A>T	c.(2668-2670)gcA>gcT	p.A890A	ZBTB21_ENST00000465968.1_5'UTR|ZBTB21_ENST00000398499.1_Silent_p.A890A|ZBTB21_ENST00000398511.3_Silent_p.A890A|ZBTB21_ENST00000398505.3_Silent_p.A689A	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		TGGCCTCGGGTGCCTCTTCTT	0.547000													12	71					0	0	1	0	0
EMX2	2018	broad.mit.edu	37	10	119303181	119303181	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:119303181C>A	ENST00000553456.3	+	1	1227	c.403C>A	c.(403-405)Caa>Aaa	p.Q135K	EMX2OS_ENST00000551288.1_RNA|EMX2_ENST00000442245.4_Missense_Mutation_p.Q135K	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	135						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		TCATCGCTTCCAAGGTACGTG	0.687000													59	132					1.11378e-47	1.72274e-47	1	1	0
DGKB	1607	broad.mit.edu	37	7	14661016	14661016	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:14661016C>A	ENST00000403951.2	-	15	1693	c.1274G>T	c.(1273-1275)gGa>gTa	p.G425V	DGKB_ENST00000399322.3_Missense_Mutation_p.G425V|DGKB_ENST00000444700.2_Missense_Mutation_p.G406V|DGKB_ENST00000402815.1_Missense_Mutation_p.G424V|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000406247.3_Missense_Mutation_p.G425V|DGKB_ENST00000258767.5_Missense_Mutation_p.G425V|DGKB_ENST00000407950.1_Missense_Mutation_p.G417V			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	425					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CAGGCCTTGTCCATCTACAGT	0.368000													5	33					0.014758	0.0151563	1	1	0
RYR1	6261	broad.mit.edu	37	19	39009873	39009873	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:39009873G>A	ENST00000355481.4	+	67	10169	c.10038G>A	c.(10036-10038)gtG>gtA	p.V3346V	RYR1_ENST00000359596.3_Silent_p.V3346V|RYR1_ENST00000360985.3_Silent_p.V3346V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3346					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCCCATTGTGAGCCGTGCAC	0.652000													25	226					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11097866	11097866	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:11097866G>A	ENST00000400897.3	-	7	907	c.892C>T	c.(892-894)Cag>Tag	p.Q298*		NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	298	Sushi 1.			QP -> HA (in Ref. 1; CAA71059, 3; CAB50733/CAB50735, 4; CAA67050 and 6; AAG50274).	complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GGGCAAGGCTGCGCTGCGCAG	0.483000											OREG0013096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	80					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566670	55566670	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:55566670A>T	ENST00000373965.2	-	36	5118	c.4724T>A	c.(4723-4725)cTg>cAg	p.L1575Q	PCDH15_ENST00000414778.1_Missense_Mutation_p.L1572Q	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	426					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGGCCCTCCCAGTCGAACAGG	0.448000										HNSCC(58;0.16)			60	132					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47653003	47653003	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:47653003C>A	ENST00000294338.2	-	2	286	c.164G>T	c.(163-165)tGc>tTc	p.C55F	PDZK1IP1_ENST00000371885.1_Missense_Mutation_p.C55F	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	55						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						CTCCTCCTGGCACCAGAAGTG	0.612000													9	38					2.80697e-09	3.27624e-09	1	1	0
THSD1	55901	broad.mit.edu	37	13	52960255	52960255	+	Missense_Mutation	SNP	C	C	T	rs150806777		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:52960255C>T	ENST00000258613.4	-	4	1266	c.1088G>A	c.(1087-1089)cGt>cAt	p.R363H	THSD1_ENST00000349258.4_Intron|THSD1_ENST00000544466.1_5'UTR	NM_018676.3	NP_061146.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	363	TSP type-1.					extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CACTCGGCGACGCTCTCTGAC	0.542000													31	196					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168114878	168114878	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:168114878C>G	ENST00000409728.1	+	11	2010	c.1921C>G	c.(1921-1923)Cat>Gat	p.H641D	XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.H608D|XIRP2_ENST00000409605.1_Missense_Mutation_p.H386D|XIRP2_ENST00000409756.2_Missense_Mutation_p.H608D|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.H641D	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2716					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAGTCCACCCATGTTTGTCA	0.358000													28	53					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306521	2306521	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:2306521T>A	ENST00000290974.2	-	8	1885	c.1546A>T	c.(1546-1548)Acg>Tcg	p.T516S	ZFYVE28_ENST00000511071.1_Missense_Mutation_p.T486S|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.T446S|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	516					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						AAGATGACCGTGGCTGAGAGC	0.687000													23	71					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37451602	37451602	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:37451602C>T	ENST00000374660.1	+	16	1857	c.1758C>T	c.(1756-1758)ttC>ttT	p.F586F	ANKRD30A_ENST00000602533.1_Silent_p.F586F|ANKRD30A_ENST00000361713.1_Silent_p.F586F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	642						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.F586L(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CATCTGCCTTCGAGGTATTTA	0.328000													5	113					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13883155	13883155	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:13883155C>A	ENST00000265104.4	-	20	3136	c.3032G>T	c.(3031-3033)cGg>cTg	p.R1011L	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1011	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GACGCTTGCCCGGAAAATGGG	0.463000									Kartagener syndrome				37	154					1.52319e-26	2.2464e-26	1	1	0
USH2A	7399	broad.mit.edu	37	1	216420199	216420199	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:216420199G>A	ENST00000366943.2	-	13	2923	c.2537C>T	c.(2536-2538)cCt>cTt	p.P846L	USH2A_ENST00000366942.3_Missense_Mutation_p.P846L|USH2A_ENST00000307340.3_Missense_Mutation_p.P846L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	846	Laminin EGF-like 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGTTGCAAGGCAGACAGAG	0.448000										HNSCC(13;0.011)			27	271					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157062486	157062486	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:157062486G>T	ENST00000454449.2	-	5	1325	c.1041C>A	c.(1039-1041)ccC>ccA	p.P347P		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	347						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				TCTCCAGATTGGGGGAAGTAA	0.562000													29	54					1.96642e-18	2.69145e-18	1	1	0
GFRA1	2674	broad.mit.edu	37	10	117885068	117885068	+	Splice_Site	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:117885068A>G	ENST00000439649.3	-	5	786	c.418_splice	c.e5-1	p.V140_splice	GFRA1_ENST00000369236.1_Splice_Site_p.V140_splice|GFRA1_ENST00000355422.6_Splice_Site_p.V145_splice|GFRA1_ENST00000544592.1_Splice_Site_p.V24_splice	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	145					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		AATGTGCTCCACTGCAAATGC	0.517000													4	24					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176562359	176562359	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:176562359G>T	ENST00000439151.2	+	2	300	c.255G>T	c.(253-255)gaG>gaT	p.E85D	NSD1_ENST00000361032.4_Missense_Mutation_p.E85D|NSD1_ENST00000347982.4_Intron|NSD1_ENST00000511258.1_Intron|NSD1_ENST00000354179.4_Intron	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	85					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCAATGTAGAGTATTTAAATG	0.433000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			23	36					2.50493e-22	3.61718e-22	1	1	0
FAR1	84188	broad.mit.edu	37	11	13716476	13716476	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:13716476G>T	ENST00000354817.3	+	2	308	c.164G>T	c.(163-165)cGa>cTa	p.R55L		NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	55					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						CCACAAGAGCGAGTGGAAGAA	0.423000													5	33					1.6384e-10	1.9697e-10	1	1	0
STEAP1	26872	broad.mit.edu	37	7	89790157	89790157	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:89790157T>C	ENST00000297205.2	+	3	323	c.123T>C	c.(121-123)ccT>ccC	p.P41P	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	41					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					TAAAAAGACCTGTGCTTTTGC	0.418000													14	196					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87680392	87680392	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:87680392C>A	ENST00000320005.5	-	5	545	c.498G>T	c.(496-498)aaG>aaT	p.K166N		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	166					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						CAGCCGTGGGCTTTGCTTCAT	0.368000													5	55					0.014758	0.0151563	1	1	0
ZNF521	25925	broad.mit.edu	37	18	22807473	22807473	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr18:22807473C>T	ENST00000361524.3	-	4	557	c.409G>A	c.(409-411)Gag>Aag	p.E137K	ZNF521_ENST00000584787.1_5'UTR|ZNF521_ENST00000538137.2_Missense_Mutation_p.E137K	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	137					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGACTCTGCTCATGGTGCTTT	0.517000			T	PAX5	ALL								28	199					0	0	1	0	0
GNAI1	2770	broad.mit.edu	37	7	79842052	79842052	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:79842052G>A	ENST00000351004.3	+	7	1114	c.741G>A	c.(739-741)atG>atA	p.M247I	GNAI1_ENST00000457358.2_Missense_Mutation_p.M195I	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	247					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						ATGAAAGCATGAAATTGTTTG	0.294000													3	42					0	0	1	0	0
ZNF7	7553	broad.mit.edu	37	8	146066790	146066790	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:146066790C>T	ENST00000528372.1	+	5	538	c.298C>T	c.(298-300)Cta>Tta	p.L100L	ZNF7_ENST00000325241.6_Silent_p.L100L|ZNF7_ENST00000544249.1_Silent_p.L4L|ZNF7_ENST00000325217.5_Intron|ZNF7_ENST00000532393.1_3'UTR|ZNF7_ENST00000529819.1_Intron|ZNF7_ENST00000525266.1_Intron|ZNF7_ENST00000446747.2_Silent_p.L111L			P17097	ZNF7_HUMAN	zinc finger protein 7	100					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(5)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		CATGGACATCCTAAAATCAGA	0.458000													31	210					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180377302	180377302	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:180377302T>A	ENST00000340184.4	+	8	1467	c.1261T>A	c.(1261-1263)Ttc>Atc	p.F421I	BTNL8_ENST00000511704.1_Missense_Mutation_p.F305I|BTNL8_ENST00000400707.3_Missense_Mutation_p.F296I|BTNL8_ENST00000508408.1_3'UTR|BTNL8_ENST00000505126.1_Missense_Mutation_p.F214I|BTNL8_ENST00000231229.4_3'UTR|BTNL8_ENST00000533815.2_Missense_Mutation_p.F237I	NM_001040462.2	NP_001035552.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	421	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATCTCCTTCTTCAACATAAA	0.443000													27	118					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48636409	48636409	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:48636409C>G	ENST00000537810.1	-	4	623	c.19G>C	c.(19-21)Gac>Cac	p.D7H	FRYL_ENST00000507711.1_Missense_Mutation_p.D7H|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000358350.4_Missense_Mutation_p.D7H|FRYL_ENST00000503238.1_Missense_Mutation_p.D7H			O94915	FRYL_HUMAN	FRY-like	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						ACATCTGGGTCAATCGTAATG	0.388000													9	72					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80085281	80085281	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:80085281G>A	ENST00000466387.1	+	8	1165	c.441G>A	c.(439-441)atG>atA	p.M147I	CTNNA2_ENST00000540488.1_Missense_Mutation_p.M147I|CTNNA2_ENST00000402739.4_Missense_Mutation_p.M147I|CTNNA2_ENST00000541047.1_Missense_Mutation_p.M147I|CTNNA2_ENST00000361291.4_Missense_Mutation_p.M181I|CTNNA2_ENST00000496558.1_Missense_Mutation_p.M147I			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	147					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CAGATGTCATGAGACTTTTAT	0.498000													12	82					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725788	87725788	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:87725788G>C	ENST00000305344.4	+	2	1439	c.736G>C	c.(736-738)Gac>Cac	p.D246H	HTR1E_ENST00000369584.1_Missense_Mutation_p.D246H	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	246					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CTGTGTGTCTGACTTCTCCAC	0.463000													45	243					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67155926	67155926	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:67155926C>A	ENST00000371037.4	+	17	1574	c.1497C>A	c.(1495-1497)ccC>ccA	p.P499P	SGIP1_ENST00000371035.3_Silent_p.P289P|SGIP1_ENST00000371036.3_Silent_p.P299P|SGIP1_ENST00000371039.1_Silent_p.P300P|SGIP1_ENST00000237247.6_Silent_p.P530P	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	499	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CAATAGCACCCTTAGCGCGGG	0.463000													32	220					4.65686e-17	6.26126e-17	1	1	0
ETFB	2109	broad.mit.edu	37	19	51857544	51857544	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:51857544T>A	ENST00000354232.4	-	1	2816	c.349A>T	c.(349-351)Agg>Tgg	p.R117W	CTD-2616J11.11_ENST00000600067.1_3'UTR|ETFB_ENST00000309244.4_Missense_Mutation_p.R26W	NM_001014763.1	NP_001014763.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	26					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity			kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		ACACCGGTCCTGTCAGGCTTC	0.622000													75	104					0	0	1	0	0
EIF3G	8666	broad.mit.edu	37	19	10226221	10226221	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:10226221G>A	ENST00000253108.4	-	10	923	c.881C>T	c.(880-882)gCg>gTg	p.A294V		NM_003755.3	NP_003746.2	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3, subunit G	294	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			central_nervous_system(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			AATGGCACGCGCAGCATCCTC	0.652000													11	44					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119886257	119886257	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:119886257T>A	ENST00000464295.1	-	10	2512	c.2067A>T	c.(2065-2067)agA>agT	p.R689S	GPR156_ENST00000461057.1_Missense_Mutation_p.R685S|GPR156_ENST00000315843.3_Missense_Mutation_p.R689S			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	689						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		CTTTGCTCCCTCTAGCCCCCT	0.592000													11	64					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755469	140755469	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140755469C>A	ENST00000517434.1	+	1	1819	c.1819C>A	c.(1819-1821)Cgc>Agc	p.R607S	PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTCCTACCGCCTGCTCAA	0.697000													18	97					2.89027e-11	3.5533e-11	1	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37447480	37447480	+	Silent	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:37447480C>A	ENST00000374660.1	+	15	1797	c.1698C>A	c.(1696-1698)gcC>gcA	p.A566A	ANKRD30A_ENST00000602533.1_Silent_p.A566A|ANKRD30A_ENST00000361713.1_Silent_p.A566A			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	622						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CAACTAAAGCCTTAGAATTGA	0.294000													17	115					1.28384e-07	1.46477e-07	1	1	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121115830	121115830	+	RNA	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:121115830A>T	ENST00000437515.1	-	0	329																											GATGTCTTGCAGGTCATGAAG	0.522000													4	52					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182033	57182033	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:57182033T>A	ENST00000504228.1	+	6	2470	c.2365T>A	c.(2365-2367)Tgc>Agc	p.C789S	KIAA1211_ENST00000541073.1_Missense_Mutation_p.C782S|KIAA1211_ENST00000264229.6_Missense_Mutation_p.C789S			Q6ZU35	K1211_HUMAN	KIAA1211	789										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CACCGAGGGATGCAAATTTGC	0.617000													15	114					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166286	19166286	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:19166286A>T	ENST00000375371.3	-	6	2348	c.2327T>A	c.(2326-2328)cTc>cAc	p.L776H		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	776					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GAAGGTGCAGAGGGAGACGGA	0.567000													12	37					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23837315	23837315	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:23837315C>A	ENST00000359788.4	-	4	588	c.420G>T	c.(418-420)caG>caT	p.Q140H	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000600313.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	140					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACATTTTGCTCTGCATAGTTG	0.289000													7	38					0.00307968	0.00323707	1	1	0
NTHL1	4913	broad.mit.edu	37	16	2089996	2089996	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:2089996A>G	ENST00000219066.1	-	6	886	c.868T>C	c.(868-870)Tgt>Cgt	p.C290R	NTHL1_ENST00000562951.1_5'UTR	NM_002528.5	NP_002519.1	P78549	NTHL1_HUMAN	nth endonuclease III-like 1 (E. coli)	290					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						ACAGGCAGACAGGTCTGCTGG	0.697000								Base excision repair (BER), DNA glycosylases					13	88					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9989900	9989900	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:9989900C>A	ENST00000256190.8	-	14	1725	c.1588G>T	c.(1588-1590)Ggt>Tgt	p.G530C		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	530					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		ACAGGTGGACCTGCTGGCACA	0.383000													25	88					7.26314e-15	9.44829e-15	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144855817	144855817	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:144855817C>A	ENST00000369359.4	-	44	7182	c.7144G>T	c.(7144-7146)Gag>Tag	p.E2382*	PDE4DIP_ENST00000369354.3_Nonsense_Mutation_p.E2246*|PDE4DIP_ENST00000369356.4_Nonsense_Mutation_p.E2246*|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.E2331*|PDE4DIP_ENST00000313382.9_Nonsense_Mutation_p.E2140*|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2246					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.E2246*(2)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GAAGCTGACTCCTCTAGGGCA	0.577000			T	PDGFRB	MPD								12	105					9.31168e-06	1.02997e-05	1	1	0
RBBP6	5930	broad.mit.edu	37	16	24570953	24570953	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:24570953G>C	ENST00000319715.4	+	8	1234	c.802G>C	c.(802-804)Gat>Cat	p.D268H	RBBP6_ENST00000381039.3_Missense_Mutation_p.D268H|RBBP6_ENST00000348022.2_Missense_Mutation_p.D268H	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	268					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TATTATGACTGATGCTGTTGT	0.388000													9	86					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247737561	247737561	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:247737561C>T	ENST00000366491.2	+	7	722	c.225C>T	c.(223-225)ctC>ctT	p.L75L	GCSAML_ENST00000366488.4_Silent_p.L95L|GCSAML_ENST00000527541.1_Silent_p.L63L|GCSAML_ENST00000527084.1_Silent_p.L63L|RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000536561.1_Silent_p.L75L|GCSAML_ENST00000366489.1_Silent_p.L75L|GCSAML_ENST00000463359.1_Silent_p.L63L					germinal center-associated, signaling and motility-like																		TTGACTCCCTCACAAGGAAAG	0.458000													7	63					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520886	33520886	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:33520886G>A	ENST00000297307.5	-	1	526	c.441C>T	c.(439-441)ctC>ctT	p.L147L		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	147	DUF6 1.					integral to membrane											TCTCAAGGCAGAGAGTGAGGA	0.582000													114	257					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77375625	77375625	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:77375625T>C	ENST00000282849.5	-	11	2104	c.1686A>G	c.(1684-1686)gaA>gaG	p.E562E		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	562	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAACGGTCCCTTCTGCTGCGG	0.423000													7	32					0	0	1	0	0
GSTA2	2939	broad.mit.edu	37	6	52619849	52619849	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:52619849A>T	ENST00000493422.1	-	4	319	c.164T>A	c.(163-165)gTg>gAg	p.V55E		NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	55	GST N-terminal.|Glutathione binding.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	AACCATTGGCACTTGCTGGAA	0.403000													68	114					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48512930	48512930	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:48512930G>C	ENST00000396577.3	+	3	735	c.520G>C	c.(520-522)Gtt>Ctt	p.V174L	SLC12A1_ENST00000330289.6_Missense_Mutation_p.V174L|SLC12A1_ENST00000558405.1_Missense_Mutation_p.V174L|SLC12A1_ENST00000561031.1_Missense_Mutation_p.V174L|SLC12A1_ENST00000380993.3_Missense_Mutation_p.V174L	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	174					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TCAAGCTGGTGTTGTGAAGTT	0.428000													5	42					0	0	1	0	0
RRAGD	58528	broad.mit.edu	37	6	90089903	90089903	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:90089903C>G	ENST00000369415.4	-	3	904	c.628G>C	c.(628-630)Gaa>Caa	p.E210Q	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.2_Missense_Mutation_p.E59Q	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	210					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		TGAATTTTTTCTAATCCAGCA	0.433000													55	137					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64299066	64299066	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:64299066G>A	ENST00000413366.3	+	1	123	c.97G>A	c.(97-99)Gag>Aag	p.E33K	PRKCA_ENST00000583361.1_3'UTR	NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	33					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding	p.E33K(1)		breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GAACGTGCACGAGGTGAAGGA	0.627000													25	138					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85984922	85984922	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:85984922C>A	ENST00000383699.3	+	7	1333	c.706C>A	c.(706-708)Cca>Aca	p.P236T	CADM2_ENST00000407528.2_Missense_Mutation_p.P227T|CADM2_ENST00000405615.2_Missense_Mutation_p.P229T	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	227	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TCTAGATACACCATCAGTTAA	0.318000													22	39					3.6726e-16	4.87757e-16	1	1	0
HP1BP3	50809	broad.mit.edu	37	1	21103111	21103111	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:21103111G>A	ENST00000312239.5	-	4	468	c.329C>T	c.(328-330)tCt>tTt	p.S110F	HP1BP3_ENST00000375000.1_Missense_Mutation_p.S110F|HP1BP3_ENST00000487117.1_5'UTR	NM_016287.3	NP_057371.2	Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	110					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TTCCTCAGAAGACTTATTTTC	0.373000													14	118					0	0	1	0	0
SERPINE2	5270	broad.mit.edu	37	2	224847403	224847403	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:224847403A>G	ENST00000409840.3	-	7	1640	c.980T>C	c.(979-981)aTa>aCa	p.I327T	SERPINE2_ENST00000447280.2_Missense_Mutation_p.I339T|SERPINE2_ENST00000258405.4_Missense_Mutation_p.I327T|SERPINE2_ENST00000409304.1_Missense_Mutation_p.I327T			P07093	GDN_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	327					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	17		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CATACTTGTTATTTTTGCAAA	0.348000													16	17					0	0	1	0	0
POLR1B	84172	broad.mit.edu	37	2	113330310	113330310	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:113330310C>T	ENST00000263331.5	+	13	2826	c.2246C>T	c.(2245-2247)aCt>aTt	p.T749I	POLR1B_ENST00000409894.3_Missense_Mutation_p.T566I|POLR1B_ENST00000417433.2_Missense_Mutation_p.T693I|POLR1B_ENST00000541869.1_Missense_Mutation_p.T787I|POLR1B_ENST00000537335.1_Missense_Mutation_p.T538I	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	749					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						ATTTCTTACACTGGCTATGAT	0.383000													35	51					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183114	140183114	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140183114C>T	ENST00000522353.2	+	1	2332	c.2332C>T	c.(2332-2334)Cct>Tct	p.P778S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.P778S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGCCTTCCTCCTTGTCCAAT	0.502000													52	112					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57574736	57574736	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:57574736G>A	ENST00000267811.5	+	19	2304	c.2000G>A	c.(1999-2001)gGa>gAa	p.G667E	TCF12_ENST00000438423.2_Missense_Mutation_p.G691E|TCF12_ENST00000452095.2_Missense_Mutation_p.G687E|TCF12_ENST00000559703.1_Missense_Mutation_p.G324E|TCF12_ENST00000559710.1_Missense_Mutation_p.G301E|TCF12_ENST00000333725.5_Missense_Mutation_p.G691E|TCF12_ENST00000343827.3_Missense_Mutation_p.G497E|TCF12_ENST00000537840.1_Missense_Mutation_p.G431E|TCF12_ENST00000557843.1_Missense_Mutation_p.G667E|TCF12_ENST00000543579.1_Missense_Mutation_p.G521E	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	667					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ACACTGCCAGGAACCCATCCT	0.473000			T	TEC	extraskeletal myxoid chondrosarcoma								22	265					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616159	140616159	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:140616159C>T	ENST00000526308.1	+	0	2222					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GAGGCTGCCCCCTCCCAGGCC	0.677000													18	76					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158724749	158724749	+	Silent	SNP	G	G	A	rs147601748		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:158724749G>A	ENST00000368144.2	+	1	240	c.144G>A	c.(142-144)gcG>gcA	p.A48A		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					TCCCGCATGCGCACAGAGGTG	0.458000													20	184					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354696	120354696	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:120354696C>G	ENST00000239032.2	-	2	199	c.61G>C	c.(61-63)Gcg>Ccg	p.A21P	PRLHR_ENST00000369169.1_Missense_Mutation_p.A21P	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	21					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GTTGTGACCGCCGGCGGCAGC	0.647000													11	65					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622322	234622322	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:234622322G>T	ENST00000373414.3	+	1	685	c.685G>T	c.(685-687)Gct>Tct	p.A229S	UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000480628.1_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		TGCTGTTTCTGCTCCTTATGC	0.498000													45	286					2.22293e-35	3.36313e-35	1	1	0
OR2T1	26696	broad.mit.edu	37	1	248569430	248569430	+	Silent	SNP	C	C	A	rs145103744		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:248569430C>A	ENST00000366474.1	+	1	135	c.135C>A	c.(133-135)atC>atA	p.I45I		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I45I(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TACCTTATATCGGCACAACTG	0.378000													37	148					3.43241e-23	5.00396e-23	1	1	0
LRP2	4036	broad.mit.edu	37	2	170077036	170077036	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:170077036G>A	ENST00000263816.3	-	34	5861	c.5576C>T	c.(5575-5577)aCa>aTa	p.T1859I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1859					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCAATCAATGTTTTTCTGTA	0.408000													9	46					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52937352	52937352	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:52937352C>A	ENST00000332323.6	+	2	221	c.160C>A	c.(160-162)Cca>Aca	p.P54T	ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000433050.1_Intron|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAATGTCCGTCCAGAAGCCTG	0.488000													40	51					1.8453e-21	2.64957e-21	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53854579	53854579	+	Silent	SNP	T	T	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:53854579T>C	ENST00000458035.1	+	4	768	c.651T>C	c.(649-651)tgT>tgC	p.C217C	ZNF845_ENST00000595091.1_Silent_p.C217C	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						CTTTCCAATGTAATGAGAGTG	0.353000													14	77					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	64990988	64990988	+	RNA	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:64990988C>G	ENST00000525437.1	+	0	1018							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						ACCTCCAACTCAATCTTGGAC	0.542000													8	78					0	0	1	0	0
ATP6V1E2	90423	broad.mit.edu	37	2	46739523	46739523	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:46739523C>G	ENST00000306448.4	-	2	1441	c.328G>C	c.(328-330)Gag>Cag	p.E110Q	ATP6V1E2_ENST00000522587.1_Missense_Mutation_p.E110Q	NM_080653.3	NP_542384.1	Q96A05	VATE2_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2	110					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain	proton-transporting ATPase activity, rotational mechanism			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.151)			TGGTAGACCTCTGGGTCCTCC	0.567000													33	45					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115489890	115489890	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:115489890A>T	ENST00000369522.3	+	27	2511	c.2271A>T	c.(2269-2271)aaA>aaT	p.K757N	SYCP1_ENST00000369518.1_Missense_Mutation_p.K757N	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	757					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAATCTCAAAGCTGAACTTT	0.323000													5	23					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83036508	83036508	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:83036508C>T	ENST00000307792.3	-	7	1185	c.718G>A	c.(718-720)Gat>Aat	p.D240N	SEMA3E_ENST00000427262.1_Missense_Mutation_p.D180N	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	240	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TTGTTGTCATCTCTGTCTTCA	0.383000													8	42					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151771946	151771946	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:151771946G>T	ENST00000255262.3	-	4	1219	c.1054C>A	c.(1054-1056)Cag>Aag	p.Q352K		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	352					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GGGTCATGCTGGGAGTGCCAC	0.517000													42	116					4.01344e-20	5.62473e-20	1	1	0
REG1P	5969	broad.mit.edu	37	2	79363950	79363950	+	RNA	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:79363950C>A	ENST00000444841.1	-	0	388																											CCAGACATTGCTATCCTTGGT	0.527000													11	34					1.08611e-07	1.2429e-07	1	1	0
TCERG1L	256536	broad.mit.edu	37	10	133107515	133107515	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr10:133107515G>T	ENST00000368642.4	-	2	475	c.390C>A	c.(388-390)tcC>tcA	p.S130S		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	130										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GCTCCACTGTGGAAGAGGGGG	0.527000													26	58					1.90571e-15	2.49183e-15	1	1	0
FBN1	2200	broad.mit.edu	37	15	48818378	48818378	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:48818378A>T	ENST00000316623.5	-	9	1392	c.937T>A	c.(937-939)Tgc>Agc	p.C313S		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	313	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGACATTTGCAAAAGTAACTG	0.408000													14	105					0	0	1	0	0
ADRB3	155	broad.mit.edu	37	8	37823713	37823713	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:37823713G>T	ENST00000345060.3	-	1	770	c.275C>A	c.(274-276)cCg>cAg	p.P92Q		NM_000025.2	NP_000016.1	P13945	ADRB3_HUMAN	adrenoceptor beta 3	92					carbohydrate metabolic process|energy reserve metabolic process|positive regulation of MAPKKK cascade	integral to plasma membrane|receptor complex	beta3-adrenergic receptor activity|protein homodimerization activity	p.P92R(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)	9	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)		Norepinephrine(DB00368)|Pindolol(DB00960)|Propranolol(DB00571)	GGCCGCCGGCGGCACCACCAG	0.672000													3	35					0.115264	0.116643	1	1	0
KIF21B	23046	broad.mit.edu	37	1	200965465	200965465	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:200965465C>A	ENST00000332129.2	-	15	2452	c.2136G>T	c.(2134-2136)aaG>aaT	p.K712N	KIF21B_ENST00000422435.2_Missense_Mutation_p.K712N|KIF21B_ENST00000360529.5_Missense_Mutation_p.K712N|KIF21B_ENST00000461742.2_Missense_Mutation_p.K712N	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	712					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CCCGCAGCCTCTTCTCATAGT	0.592000													37	282					1.15505e-17	1.57244e-17	1	1	0
PROM2	150696	broad.mit.edu	37	2	95943294	95943294	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:95943294C>G	ENST00000317620.9	+	7	1088	c.955C>G	c.(955-957)Ctg>Gtg	p.L319V	PROM2_ENST00000463580.1_Intron|PROM2_ENST00000542147.1_Missense_Mutation_p.L319V|PROM2_ENST00000403131.2_Missense_Mutation_p.L319V|PROM2_ENST00000317668.4_Missense_Mutation_p.L319V	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	319						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						CACCCTGGAGCTGGGTGCTGA	0.647000													7	26					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358039	112358039	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:112358039C>T	ENST00000206423.3	-	2	1667	c.714G>A	c.(712-714)ctG>ctA	p.L238L	CCDC80_ENST00000439685.2_Silent_p.L238L	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	238										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GCGTCTTCTTCAGCAGCACCA	0.582000													34	180					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332284	70332284	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:70332284C>T	ENST00000338508.4	-	32	4116	c.4117G>A	c.(4117-4119)Ggc>Agc	p.G1373S	SHANK2_ENST00000423696.2_Missense_Mutation_p.G993S|SHANK2_ENST00000409161.1_Missense_Mutation_p.G776S|SHANK2_ENST00000449833.2_Missense_Mutation_p.G777S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	993					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ATGGTTCTGCCGGGCACGGTG	0.612000													22	38					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33360935	33360935	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:33360935G>C	ENST00000303296.4	+	6	1773	c.1468G>C	c.(1468-1470)Gct>Cct	p.A490P	HIPK3_ENST00000456517.1_Missense_Mutation_p.A490P|HIPK3_ENST00000525975.1_Missense_Mutation_p.A490P|HIPK3_ENST00000379016.3_Missense_Mutation_p.A490P	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	490	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						TGATCTTTTGGCTGAGAAAGC	0.358000													19	110					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104742541	104742541	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr7:104742541C>A	ENST00000334877.4	+	17	2630	c.2096C>A	c.(2095-2097)aCa>aAa	p.T699K	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000257745.4_Missense_Mutation_p.T699K|KMT2E_ENST00000311117.3_Missense_Mutation_p.T699K					lysine (K)-specific methyltransferase 2E																		ACTGTACTTACAATAGAACCA	0.368000													32	54					5.43694e-19	7.48193e-19	1	1	0
PLG	5340	broad.mit.edu	37	6	161128761	161128761	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:161128761A>T	ENST00000308192.9	+	3	278	c.215A>T	c.(214-216)cAa>cTa	p.Q72L	PLG_ENST00000462918.1_3'UTR|PLG_ENST00000366924.2_Missense_Mutation_p.Q72L	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	72	PAN.			Q -> E (in Ref. 7; AA sequence and 8; AA sequence).	extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAAGAGCAACAATGTGTGATA	0.328000													29	122					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10653446	10653446	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:10653446C>A	ENST00000254958.5	-	2	805	c.290G>T	c.(289-291)gGg>gTg	p.G97V		NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	97					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						AGGCGTGGACCCTGAGCCGAA	0.642000									Alagille Syndrome				22	125					9.86323e-18	1.34515e-17	1	1	0
UXS1	80146	broad.mit.edu	37	2	106761740	106761740	+	Silent	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:106761740G>A	ENST00000283148.7	-	6	475	c.378C>T	c.(376-378)ttC>ttT	p.F126F	UXS1_ENST00000540130.1_Silent_p.F64F|UXS1_ENST00000428048.2_Intron|UXS1_ENST00000409501.3_Silent_p.F121F|UXS1_ENST00000479621.1_5'UTR	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	121					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						TGCCCGTGAAGAAATTGTCCA	0.552000													18	65					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52952347	52952347	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr13:52952347C>T	ENST00000349258.4	-	4	2143	c.1599G>A	c.(1597-1599)cgG>cgA	p.R533R	THSD1_ENST00000258613.4_Silent_p.R586R|THSD1_ENST00000544466.1_Silent_p.R207R	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	586						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGGATTTGATCCGGAACTTGT	0.582000													16	99					0	0	1	0	0
EEFSEC	60678	broad.mit.edu	37	3	128127091	128127091	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:128127091C>T	ENST00000254730.6	+	7	1834	c.1780C>T	c.(1780-1782)Cag>Tag	p.Q594*	EEFSEC_ENST00000483457.1_3'UTR	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	594						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						GCGCATGGTTCAGTCTCCCTG	0.637000													10	114					0	0	1	0	0
ASNA1	439	broad.mit.edu	37	19	12856460	12856460	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:12856460G>A	ENST00000591090.1	+	5	598	c.496G>A	c.(496-498)Gac>Aac	p.D166N	ASNA1_ENST00000357332.3_Missense_Mutation_p.D166N			O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	166					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			endometrium(1)|lung(6)|ovary(3)	10					Adenosine triphosphate(DB00171)	GGTGGTATTTGACACGGCACC	0.642000													15	81					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233393854	233393854	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:233393854G>A	ENST00000258229.8	-	5	1988	c.1754C>T	c.(1753-1755)tCc>tTc	p.S585F	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	585						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGTATTAATGGATTCTAACAG	0.448000													5	68					0	0	1	0	0
PIGT	51604	broad.mit.edu	37	20	44049302	44049302	+	Silent	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:44049302C>T	ENST00000279036.6	+	8	1082	c.1002C>T	c.(1000-1002)atC>atT	p.I334I	PIGT_ENST00000543458.2_Silent_p.I278I|PIGT_ENST00000535404.1_Silent_p.I179I|PIGT_ENST00000341555.5_Silent_p.I140I|PIGT_ENST00000545755.1_Silent_p.I72I|PIGT_ENST00000279035.9_Silent_p.I232I|PIGT_ENST00000372689.5_Silent_p.I334I	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	334					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				ACCTCAACATCCAGCTCAAGT	0.512000													16	138					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005684	118005684	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:118005684C>A	ENST00000310754.4	-	1	1052	c.866G>T	c.(865-867)gGa>gTa	p.G289V		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	289	TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						ATTTACATTTCCAGTAAGGGC	0.448000													32	44					1.36161e-19	1.88741e-19	1	1	0
RP11-337C18.8	0	broad.mit.edu	37	1	146649760	146649760	+	RNA	SNP	C	C	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr1:146649760C>T	ENST00000607149.1	+	0	350																											CGCCTCGCGGCTGCCTCCGAC	0.721000													24	33					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802202	54802202	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:54802202G>T	ENST00000391745.1	-	10	1353	c.1037C>A	c.(1036-1038)tCc>tAc	p.S346Y	LILRA3_ENST00000391744.3_Missense_Mutation_p.S265Y|LILRA3_ENST00000251390.3_Missense_Mutation_p.S329Y					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGGCCGCACGGAGAGGAAGGG	0.632000													38	52					1.89013e-27	2.79842e-27	1	1	0
HTT	3064	broad.mit.edu	37	4	3107098	3107098	+	Silent	SNP	G	G	T			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:3107098G>T	ENST00000355072.5	+	5	688	c.543G>T	c.(541-543)cgG>cgT	p.R181R		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	181					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTGCCCCTCGGAGTTTGCGTG	0.507000													15	116					2.48551e-13	3.15771e-13	1	1	0
IRF8	3394	broad.mit.edu	37	16	85952322	85952322	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:85952322G>A	ENST00000268638.5	+	7	1323	c.901G>A	c.(901-903)Ggc>Agc	p.G301S	IRF8_ENST00000562492.1_Missense_Mutation_p.G97S	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	301					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				GTTCTGCAGCGGCAACGCCGT	0.662000													4	45					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116539944	116539944	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:116539944delG	ENST00000410059.1	+	17	1980	c.1500delG	c.(1498-1500)gtfs	p.V501fs	DPP10_ENST00000393147.2_Frame_Shift_Del_p.V505fs|DPP10_ENST00000310323.8_Frame_Shift_Del_p.V494fs|DPP10_ENST00000409163.1_Frame_Shift_Del_p.V451fs	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	501					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						GGGTCCCAGTGGTCAGCCTAC	0.333													22	157	---	---	---	---					
COL4A3	1285	broad.mit.edu	37	2	228145646	228145646	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr2:228145646delA	ENST00000396578.3	+	31	2574	c.2412delA	c.(2410-2412)ggfs	p.G804fs	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	804	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GAGAACAAGGACCCCCAGGAA	0.527													2	4	---	---	---	---					
PRRT3	285368	broad.mit.edu	37	3	9991858	9991859	+	Splice_Site	INS	-	-	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr3:9991858_9991859insA	ENST00000412055.1	-	2	73		c.e2-2		PRRT3-AS1_ENST00000431558.1_RNA|PRRT3_ENST00000411976.2_Splice_Site	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3							integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						TGGATGAGCCTAAAAAAAAAAC	0.574													3	6	---	---	---	---					
PCDH7	5099	broad.mit.edu	37	4	30726212	30726212	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr4:30726212delC	ENST00000361762.2	+	1	4176	c.3168delC	c.(3166-3168)agfs	p.S1056fs	PCDH7_ENST00000543491.1_Frame_Shift_Del_p.S1056fs	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	1056					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						ACAAGTACAGCAAACAGGTAA	0.388													7	50	---	---	---	---					
ZNF300	91975	broad.mit.edu	37	5	150275109	150275109	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr5:150275109delA	ENST00000446148.2	-	7	2167	c.1740delT	c.(1738-1740)ctfs	p.L580fs	ZNF300_ENST00000274599.5_Frame_Shift_Del_p.L564fs|ZNF300_ENST00000418587.2_Frame_Shift_Del_p.L528fs|ZNF300_ENST00000427179.1_3'UTR|ZNF300_ENST00000394226.2_Frame_Shift_Del_p.L564fs	NM_001172831.1	NP_001166302.1	Q96RE9	ZN300_HUMAN	zinc finger protein 300	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATGTAAAACAAGGTCTGACT	0.453													11	74	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32522379	32522380	+	RNA	INS	-	-	C	rs112115106		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr6:32522379_32522380insC	ENST00000411500.1	-	0	740					NR_001298.1																						TGAAAATAGGATTGGGAGAGTA	0.475													7	30	---	---	---	---					
FABP4	2167	broad.mit.edu	37	8	82392704	82392704	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:82392704delC	ENST00000256104.4	-	2	298	c.203delG	c.(202-204)gcfs	p.G68fs	FABP4_ENST00000518669.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_001442.2	NP_001433.1	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	68					triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity			breast(2)|central_nervous_system(1)|large_intestine(1)|ovary(1)|skin(1)	6			Epithelial(68;0.213)			AAATTCCTGGCCCAGTATGAA	0.423													89	121	---	---	---	---					
TG	7038	broad.mit.edu	37	8	134128909	134128909	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr8:134128909delC	ENST00000220616.4	+	45	7851	c.7811delC	c.(7810-7812)gcfs	p.A2604fs	TG_ENST00000519543.1_Frame_Shift_Del_p.A737fs|TG_ENST00000542445.1_Frame_Shift_Del_p.A974fs|TG_ENST00000377869.1_Frame_Shift_Del_p.A2547fs	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2604					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCAAAGAGGGCCCGAGGAAAC	0.502													21	163	---	---	---	---					
RP11-358H18.3	0	broad.mit.edu	37	11	17717451	17717452	+	RNA	INS	-	-	GGGCCG	rs77540938		TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:17717451_17717452insGGGCCG	ENST00000524479.1	+	0	314				RP11-358H18.2_ENST00000529781.1_RNA																							gagaggggccagggccggggcc	0.797													2	4	---	---	---	---					
NAV2	89797	broad.mit.edu	37	11	19735451	19735451	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:19735451delG	ENST00000396085.1	+	1	571	c.210delG	c.(208-210)gcfs	p.A70fs	NAV2_ENST00000349880.4_Frame_Shift_Del_p.A70fs|NAV2_ENST00000396087.3_Frame_Shift_Del_p.A70fs|NAV2_ENST00000360655.4_Intron	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	70						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AGGAGCCAGCGGGGGAGGGGC	0.617													24	62	---	---	---	---					
DDX10	1662	broad.mit.edu	37	11	108788635	108788637	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr11:108788635_108788637delTGA	ENST00000526794.1	+	17	2372_2374	c.2340_2342delTGA	c.(2338-2343)agt>ag	p.SD780del	DDX10_ENST00000322536.3_In_Frame_Del_p.SD780del			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	780							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGGATTGGAGtgatgatgatgat	0.355			T	NUP98	AML*								7	52	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546788	11546790	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:11546788_11546790delGGA	ENST00000389362.4	-	3	257_259	c.222_224delTCC	c.(220-225)cca>cc	p.PP74del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGCTTTCCTGGAGGAGGTGGGG	0.601													9	254	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56557518	56557530	+	Frame_Shift_Del	DEL	TGTGGGGTCTGGA	TGTGGGGTCTGGA	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:56557518_56557530delTGTGGGGTCTGGA	ENST00000394023.3	-	30	3507_3519	c.3402_3414delTCCAGACCCCACA	c.(3400-3414)ccfs	p.PPDPT1134fs	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Frame_Shift_Del_p.PPDPT1227fs|SMARCC2_ENST00000267064.4_Frame_Shift_Del_p.PPDPT1196fs|SMARCC2_ENST00000347471.4_Frame_Shift_Del_p.PPDPT1112fs	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1088	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGCTCGGGGCTGTGGGGTCTGGAGGCAGGGGGG	0.615													7	68	---	---	---	---					
XPOT	11260	broad.mit.edu	37	12	64812795	64812795	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:64812795delG	ENST00000332707.5	+	6	939	c.410delG	c.(409-411)agfs	p.R137fs		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	137	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		CTAAATCCAAGGGGAGTAGAT	0.438													27	133	---	---	---	---					
MDM1	56890	broad.mit.edu	37	12	68707424	68707425	+	Splice_Site	INS	-	-	A			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr12:68707424_68707425insA	ENST00000303145.7	-	10	1694_1695	c.1609_splice	c.e10+1	p.W537_splice	MDM1_ENST00000411698.2_Splice_Site_p.W502_splice|MDM1_ENST00000540418.1_Splice_Site_p.W257_splice	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	537						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TGCCGATTACCAACAGCTGGAG	0.431													11	140	---	---	---	---					
AHNAK2	113146	broad.mit.edu	37	14	105406488	105406488	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr14:105406488delG	ENST00000333244.5	-	7	15419	c.15300delC	c.(15298-15300)gcfs	p.A5100fs	AHNAK2_ENST00000557457.1_Frame_Shift_Del_p.A98fs	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5100						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GATCAGGTTTGGCAAAGCCCA	0.567													29	190	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25331892	25331892	+	RNA	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr15:25331892delG	ENST00000546682.1	+	0	453				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						ACAGGGAAGTGGGAGCTCCCA	0.517													5	9	---	---	---	---					
ZNF423	23090	broad.mit.edu	37	16	49670340	49670341	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:49670340_49670341insC	ENST00000561648.1	-	4	2775_2776	c.2722_2723insG	c.(2722-2724)ccafs	p.P908fs	ZNF423_ENST00000567169.1_Frame_Shift_Ins_p.P791fs|ZNF423_ENST00000562520.1_Frame_Shift_Ins_p.P848fs|ZNF423_ENST00000535559.1_Frame_Shift_Ins_p.P791fs|ZNF423_ENST00000563137.2_Frame_Shift_Ins_p.P848fs|ZNF423_ENST00000562871.1_Frame_Shift_Ins_p.P848fs|ZNF423_ENST00000262383.2_Frame_Shift_Ins_p.P908fs	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	908					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GATATTGTGGTCCCGCAGCCGG	0.589													65	177	---	---	---	---					
ACD	65057	broad.mit.edu	37	16	67693646	67693648	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr16:67693646_67693648delGCA	ENST00000219251.8	-	3	873_875	c.542_544delTGC	c.(541-546)cag>c	p.LQ181del	ACD_ENST00000393919.4_In_Frame_Del_p.LQ184del	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	184					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding	p.L181delL(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCGCAGTCCTGCAGCAGCAGCAG	0.650													7	398	---	---	---	---					
ABCC3	8714	broad.mit.edu	37	17	48745000	48745000	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr17:48745000delG	ENST00000285238.8	+	12	1597	c.1517delG	c.(1516-1518)tgfs	p.W506fs	ABCC3_ENST00000427699.1_Frame_Shift_Del_p.W506fs	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	506	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CTGTACGCCTGGGAGCCCAGC	0.577													15	40	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207065	1207065	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:1207065delG	ENST00000326873.7	+	1	1326	c.153delG	c.(151-153)atfs	p.M51fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	51	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.D53fs*11(1)|p.L50_D53del(1)|p.M51fs*14(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTACCTGATGGGGGACCTGC	0.607		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			15	49	---	---	---	---					
AP3D1	8943	broad.mit.edu	37	19	2117262	2117262	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr19:2117262delT	ENST00000355272.6	-	16	2024	c.1818delA	c.(1816-1818)ccfs	p.P606fs	AP3D1_ENST00000356926.4_Frame_Shift_Del_p.P515fs|AP3D1_ENST00000350812.6_Frame_Shift_Del_p.P437fs|AP3D1_ENST00000345016.5_Frame_Shift_Del_p.P606fs	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	606					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGGGCCACTGGGTTCAGCT	0.612													8	25	---	---	---	---					
C20orf85	128602	broad.mit.edu	37	20	56735727	56735727	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr20:56735727delC	ENST00000371168.3	+	4	324	c.263delC	c.(262-264)tcfs	p.S88fs		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	88										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GTCTTTCCATCCCCCCCAGTC	0.582													7	119	---	---	---	---					
CBR3-AS1	100506428	broad.mit.edu	37	21	37518894	37518894	+	RNA	DEL	T	T	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chr21:37518894delT	ENST00000413862.1	-	0	79				CBR3-AS1_ENST00000453159.1_RNA|CBR3-AS1_ENST00000427491.1_RNA	NR_038892.1																						atttctgttcttttttttttt	0.448													2	4	---	---	---	---					
TENM1	10178	broad.mit.edu	37	X	123514833	123514833	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8092-01A-11D-2238-08	TCGA-55-8092-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e9d858d-0828-4723-a680-d42bc955a299	ef1c28ac-9374-4a33-b898-e9305aa26b0a	g.chrX:123514833delC	ENST00000422452.2	-	32	7815	c.7752delG	c.(7750-7752)aafs	p.K2584fs	TENM1_ENST00000371130.3_Frame_Shift_Del_p.K2577fs|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GAGACCCAAGCTTAATGAAGT	0.498													59	44	---	---	---	---					
