Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
QSER1	79832	broad.mit.edu	37	11	32954673	32954673	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:32954673T>G	ENST00000399302.2	+	4	1817	c.1482T>G	c.(1480-1482)atT>atG	p.I494M	QSER1_ENST00000527788.1_Missense_Mutation_p.I255M	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	494	Ser-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					AGAATTATATTTCTATGCATT	0.458000													10	99					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22294457	22294457	+	Silent	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:22294457T>G	ENST00000324559.8	+	19	2474	c.2157T>G	c.(2155-2157)acT>acG	p.T719T	ANO5_ENST00000532043.1_3'UTR	NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	719						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACAGGAGAACTGTAGCTTCTA	0.418000													7	139					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155628911	155628911	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr3:155628911C>T	ENST00000496455.1	+	7	1064	c.729C>T	c.(727-729)ctC>ctT	p.L243L	GMPS_ENST00000295920.7_Silent_p.L144L	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	243					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGGTTTTACTCAGTGGTGGAG	0.338000			T	MLL	AML								10	87					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21175843	21175843	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:21175843C>T	ENST00000381541.3	+	5	606	c.541C>T	c.(541-543)Cgt>Tgt	p.R181C	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.R181C|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.R134C																							TAATATGCTTCGTGGCATAGG	0.368000													14	96					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99914762	99914762	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:99914762C>T	ENST00000332397.6	+	8	1514	c.1330C>T	c.(1330-1332)Cat>Tat	p.H444Y	SPDYE3_ENST00000437326.2_Missense_Mutation_p.H67Y	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	444										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						CCAACGCATTCATTTCTTCCT	0.532000													15	250					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23521729	23521729	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr14:23521729C>T	ENST00000397359.3	-	8	1575	c.1316G>A	c.(1315-1317)cGc>cAc	p.R439H	CDH24_ENST00000487137.2_Missense_Mutation_p.R439H|CDH24_ENST00000267383.5_Missense_Mutation_p.R439H|CDH24_ENST00000554034.1_Missense_Mutation_p.R439H	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	439	Cadherin 4.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GCGAGCCTCGCGATCCAGGGG	0.642000													12	73					0	0	1	0	0
SMG9	56006	broad.mit.edu	37	19	44254841	44254841	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:44254841C>A	ENST00000601170.1	-	2	367	c.53G>T	c.(52-54)cGa>cTa	p.R18L	SMG9_ENST00000270066.6_Missense_Mutation_p.R18L			Q9H0W8	SMG9_HUMAN	SMG9 nonsense mediated mRNA decay factor	18					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(7)|pancreas(1)|prostate(2)|urinary_tract(2)	19						CTTCCACCGTCGCCGCCGCTC	0.572000													21	222					3.62473e-10	4.10803e-10	1	1	0
KIF21B	23046	broad.mit.edu	37	1	200971387	200971387	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:200971387C>T	ENST00000332129.2	-	9	1620	c.1304G>A	c.(1303-1305)cGg>cAg	p.R435Q	KIF21B_ENST00000422435.2_Missense_Mutation_p.R435Q|KIF21B_ENST00000360529.5_Missense_Mutation_p.R435Q|KIF21B_ENST00000461742.2_Missense_Mutation_p.R435Q	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	435					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CACCCGCAGCCGCAGGGCCCC	0.602000													5	136					0	0	1	0	0
IBA57	200205	broad.mit.edu	37	1	228362506	228362506	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:228362506A>G	ENST00000366711.3	+	2	457	c.455A>G	c.(454-456)gAg>gGg	p.E152G	IBA57_ENST00000484749.1_3'UTR|IBA57_ENST00000546123.1_5'UTR	NM_001010867.2	NP_001010867.1	Q5T440	CAF17_HUMAN	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	152					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|prostate(1)	11						GTCACGGTGGAGCCGCACCCG	0.682000													7	19					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74460691	74460691	+	Splice_Site	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:74460691C>G	ENST00000394019.2	-	23	2831		c.e23-1		SLC4A5_ENST00000423644.1_Splice_Site|SLC4A5_ENST00000377632.1_Splice_Site|SLC4A5_ENST00000377634.4_Splice_Site|SLC4A5_ENST00000359484.4_Splice_Site|SLC4A5_ENST00000358683.4_Splice_Site|SLC4A5_ENST00000357822.5_Splice_Site|SLC4A5_ENST00000346834.4_Splice_Site|SLC4A5_ENST00000483195.1_Splice_Site|RP11-287D1.3_ENST00000451608.2_Splice_Site	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5							apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GCCGCGTTGGCTGAGTGGGAG	0.627000													5	28					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54853322	54853322	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:54853322A>C	ENST00000333896.5	+	11	1941	c.1556A>C	c.(1555-1557)aAg>aCg	p.K519T	SPTBN1_ENST00000356805.4_Missense_Mutation_p.K532T	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	532					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGGCTGCAGAAGATATTCCAG	0.522000													32	51					0	0	1	0	0
PRPF40A	55660	broad.mit.edu	37	2	153573945	153573945	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:153573945G>C	ENST00000410080.1	-	1	550	c.9C>G	c.(7-9)agC>agG	p.S3R	PRPF40A_ENST00000486100.1_5'UTR	NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	0					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						GGCCACTGCCGCTACACATAC	0.647000													7	99					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861181	55861181	+	Nonsense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:55861181C>A	ENST00000302124.2	+	1	429	c.398C>A	c.(397-399)tCa>tAa	p.S133*	OR8I2_ENST00000560768.1_Nonsense_Mutation_p.S133*			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TTACTGTATTCAGTAGTCATG	0.433000													12	158					4.3838e-07	4.80804e-07	1	1	0
PIK3AP1	118788	broad.mit.edu	37	10	98469621	98469621	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr10:98469621G>T	ENST00000339364.5	-	2	252	c.133C>A	c.(133-135)Cac>Aac	p.H45N		NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	45						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCCAGCCTGTGAGTCAGTATC	0.627000													5	65					0.0215528	0.0222059	1	1	0
RLIM	51132	broad.mit.edu	37	X	73811606	73811606	+	Missense_Mutation	SNP	C	C	T	rs143249444	by1000genomes	TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:73811606C>T	ENST00000332687.6	-	4	1762	c.1544G>A	c.(1543-1545)aGg>aAg	p.R515K	RLIM_ENST00000349225.2_Missense_Mutation_p.R515K	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	515					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GACTGGGGCCCTATGTCGACC	0.478000													4	62					0	0	1	0	0
FBXO31	79791	broad.mit.edu	37	16	87377224	87377224	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:87377224G>T	ENST00000311635.7	-	4	649	c.637C>A	c.(637-639)Ccc>Acc	p.P213T		NM_024735.3	NP_079011.3	Q5XUX0	FBX31_HUMAN	F-box protein 31	213					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCGTGGTGGGGCCCTTTGTGG	0.632000													5	10					1	1	1	1	0
ABLIM3	22885	broad.mit.edu	37	5	148617020	148617020	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:148617020G>C	ENST00000506113.1	+	10	1380	c.898G>C	c.(898-900)Gat>Cat	p.D300H	RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000309868.7_Missense_Mutation_p.D300H|ABLIM3_ENST00000356541.3_Intron|AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000504238.1_Intron|ABLIM3_ENST00000508983.1_Missense_Mutation_p.D300H|ABLIM3_ENST00000326685.7_Intron|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000519549.1_3'UTR			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	300					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTAAAGTGGATAATGAGAT	0.443000													14	107					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61611659	61611659	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:61611659C>T	ENST00000583023.1	+	5	1099	c.1088C>T	c.(1087-1089)aCt>aTt	p.T363I	KCNH6_ENST00000581784.1_Missense_Mutation_p.T363I|KCNH6_ENST00000314672.5_Missense_Mutation_p.T363I|KCNH6_ENST00000580652.1_Missense_Mutation_p.T363I|KCNH6_ENST00000456941.2_Missense_Mutation_p.T363I	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	363					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	ATCTTCCGCACTGGCTCCGAT	0.652000													6	81					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942711	10942711	+	Splice_Site	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr21:10942711C>T	ENST00000298232.7	-	12	1043	c.676_splice	c.e12+1	p.E226_splice	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Splice_Site_p.E206_splice|TPTE_ENST00000361285.4_Splice_Site_p.E244_splice	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	244					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.E226K(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTCACAAACCTGTAACGTAA	0.333000													25	398					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34203933	34203933	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr20:34203933G>T	ENST00000374273.3	+	1	120	c.8G>T	c.(7-9)cGa>cTa	p.R3L		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	3					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			AGGATGCGGCGAAGCTCCCGC	0.677000													9	64					9.70103e-10	1.08737e-09	1	1	0
CDHR1	92211	broad.mit.edu	37	10	85956372	85956372	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr10:85956372G>A	ENST00000372117.3	+	3	366	c.263G>A	c.(262-264)gGa>gAa	p.G88E	CDHR1_ENST00000332904.3_Missense_Mutation_p.G88E	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	88	Cadherin 1.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CCCACTTTTGGAAACATCACC	0.562000													6	112					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15760978	15760978	+	Silent	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:15760978A>G	ENST00000221307.7	+	7	951	c.903A>G	c.(901-903)gtA>gtG	p.V301V	CYP4F3_ENST00000592424.1_3'UTR|CYP4F3_ENST00000586182.1_Silent_p.V301V|CYP4F3_ENST00000585846.1_Silent_p.V301V|CYP4F3_ENST00000591058.1_Silent_p.V301V	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	301					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TCATTGATGTACTCCTGCTGA	0.507000													6	99					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237831	29237831	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr14:29237831C>T	ENST00000382535.3	+	2	1715	c.1346C>T	c.(1345-1347)tCg>tTg	p.S449L	FOXG1_ENST00000313071.4_Missense_Mutation_p.S449L			P55316	FOXG1_HUMAN	forkhead box G1	449				QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2; CAA55038).|ST -> RP (in Ref. 1; CAA52239).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CAGGCCCCCTCGACCCTGCCC	0.582000													10	101					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84215615	84215615	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:84215615C>T	ENST00000567759.1	-	8	953	c.771G>A	c.(769-771)ggG>ggA	p.G257G	TAF1C_ENST00000566732.1_Silent_p.G257G|TAF1C_ENST00000541676.1_Silent_p.G190G|TAF1C_ENST00000378541.4_Silent_p.G257G|TAF1C_ENST00000341690.6_Silent_p.G190G|TAF1C_ENST00000570117.1_5'UTR	NM_005679.3	NP_005670.3	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	257					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						GTCCAGGTTTCCCAAGGAATT	0.547000													11	84					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101092607	101092607	+	Silent	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:101092607T>C	ENST00000537026.1	-	15	1298	c.939A>G	c.(937-939)ctA>ctG	p.L313L	NXF5_ENST00000473265.2_Silent_p.L313L|NXF5_ENST00000361708.2_Silent_p.L313L	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	313	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						TTGTGTGCTTTAGCAGCTTCC	0.537000													26	161					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890639	32890639	+	RNA	SNP	T	T	C	rs79284655		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:32890639T>C	ENST00000330048.5	-	0	3159					NR_003083.2																						ACCAGCGGCTTGTAGTACACA	0.627000													3	30					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39541063	39541063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr13:39541063C>A	ENST00000379631.4	-	7	1119	c.775G>T	c.(775-777)Gag>Tag	p.E259*	STOML3_ENST00000423210.1_Nonsense_Mutation_p.E250*	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	259						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GAATTCTTCTCGGTGGCTACC	0.507000													11	15					3.07112e-06	3.33249e-06	1	1	0
MUC3A	4584	broad.mit.edu	37	7	100608808	100608808	+	Silent	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:100608808C>G	ENST00000319509.7	+	7	2187	c.2187C>G	c.(2185-2187)gtC>gtG	p.V729V	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TCCGCTGTGTCACCAAATGCA	0.662000													4	64					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197297641	197297641	+	Missense_Mutation	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:197297641T>C	ENST00000367400.3	+	2	295	c.160T>C	c.(160-162)Tgt>Cgt	p.C54R	CRB1_ENST00000538660.1_Missense_Mutation_p.C54R|CRB1_ENST00000367399.2_Missense_Mutation_p.C54R|CRB1_ENST00000535699.1_5'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	54	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGACAATGATTGTTCTTGTTC	0.383000													11	55					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139096946	139096946	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr3:139096946C>G	ENST00000333188.5	-	5	622	c.441G>C	c.(439-441)caG>caC	p.Q147H	COPB2_ENST00000507777.1_Missense_Mutation_p.Q118H	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	147					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						TGATCACAATCTGCATAACAT	0.403000													5	159					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310245	22310245	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:22310245C>G	ENST00000337107.6	+	5	440	c.421C>G	c.(421-423)Ctc>Gtc	p.L141V		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	141	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						CGCCGTCCAGCTCGCCTCACT	0.632000													8	119					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154172335	154172335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:154172335C>T	ENST00000336314.4	+	4	511	c.487C>T	c.(487-489)Cga>Tga	p.R163*		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	240							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGATTGCCAGCGAGGCGGGCA	0.512000													22	44					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44004438	44004438	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:44004438G>A	ENST00000262726.7	-	22	2858	c.2605C>T	c.(2605-2607)Cgc>Tgc	p.R869C	EFCAB6_ENST00000396231.2_Missense_Mutation_p.R717C	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	869	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				ATGTCCCGGCGTCGAAGAATG	0.438000													6	87					0	0	1	0	0
NEU3	10825	broad.mit.edu	37	11	74716698	74716698	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:74716698G>T	ENST00000294064.4	+	3	1474	c.547G>T	c.(547-549)Ggc>Tgc	p.G183C	NEU3_ENST00000544263.1_Missense_Mutation_p.G150C|NEU3_ENST00000532963.1_3'UTR|NEU3_ENST00000531509.1_Missense_Mutation_p.G183C|NEU3_ENST00000529024.1_Intron|NEU3_ENST00000545272.1_Missense_Mutation_p.G74C	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	183										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						GGAGGTCATTGGCTCAGAGCT	0.547000													16	171					3.52763e-06	3.8076e-06	1	1	0
NCKAP1	10787	broad.mit.edu	37	2	183853802	183853802	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:183853802G>C	ENST00000360982.2	-	10	1679	c.921C>G	c.(919-921)ttC>ttG	p.F307L	NCKAP1_ENST00000361354.3_Missense_Mutation_p.F301L	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	301					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGTGAATGTGGAAAACTTCAT	0.413000													8	67					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61081540	61081540	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:61081540G>A	ENST00000301764.7	-	14	2129	c.1732C>T	c.(1732-1734)Cac>Tac	p.H578Y	DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	578	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						ATCTCCTTGTGCAGTAGTTCA	0.502000								Nucleotide excision repair (NER)					24	81					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138820082	138820082	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:138820082C>T	ENST00000370557.1	-	28	4299	c.3272G>A	c.(3271-3273)aGt>aAt	p.S1091N	ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000327569.3_Missense_Mutation_p.S1097N|ATP11C_ENST00000359686.2_Missense_Mutation_p.S1097N|ATP11C_ENST00000361648.2_Missense_Mutation_p.S1097N|ATP11C_ENST00000370543.1_Missense_Mutation_p.S1097N			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	1097					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					TACCCTGGCACTTCTTCTTCT	0.353000													5	53					0	0	1	0	0
M1AP	130951	broad.mit.edu	37	2	74867189	74867189	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:74867189G>T	ENST00000290536.5	-	2	330	c.214C>A	c.(214-216)Cag>Aag	p.Q72K	M1AP_ENST00000409585.1_Missense_Mutation_p.Q72K|M1AP_ENST00000358434.2_5'UTR|M1AP_ENST00000536235.1_Missense_Mutation_p.Q72K	NM_138804.3	NP_620159.2			meiosis 1 associated protein																		CACTCATGCTGATCTTGTACC	0.443000													16	73					6.49762e-13	7.48878e-13	1	1	0
ACE	1636	broad.mit.edu	37	17	61561748	61561748	+	Silent	SNP	C	C	T	rs140086153		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:61561748C>T	ENST00000290866.4	+	12	1791	c.1767C>T	c.(1765-1767)gtC>gtT	p.V589V	ACE_ENST00000428043.1_Silent_p.V589V	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	589	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AGGACATGGTCGGCTTAGATG	0.642000													6	40					0	0	1	0	0
CCDC15	80071	broad.mit.edu	37	11	124857840	124857840	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:124857840A>G	ENST00000529051.1	+	8	1977	c.1718A>G	c.(1717-1719)gAc>gGc	p.D573G	CCDC15_ENST00000344762.5_Missense_Mutation_p.D573G			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	573						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CTTCCCAAAGACCAAAATATT	0.433000													9	381					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158923996	158923996	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:158923996G>C	ENST00000367097.3	+	13	4658	c.3301G>C	c.(3301-3303)Gag>Cag	p.E1101Q	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1101					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CTGTCAGCTTGAGAAGCCCTT	0.647000													9	125					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927112	92927112	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:92927112C>T	ENST00000373079.3	-	1	1455	c.1192G>A	c.(1192-1194)Gat>Aat	p.D398N	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	398					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						CCTTTGCAATCTTCAATTTCC	0.423000													3	29					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577117	7577117	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:7577117A>C	ENST00000420246.2	-	8	953	c.821T>G	c.(820-822)gTt>gGt	p.V274G	TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.V274G|TP53_ENST00000359597.4_Missense_Mutation_p.V274G|TP53_ENST00000455263.2_Missense_Mutation_p.V274G|TP53_ENST00000269305.4_Missense_Mutation_p.V274G	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	274	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> I (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V274A(19)|p.V274D(9)|p.V274G(8)|p.0?(8)|p.?(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V274_P278del(1)|p.F270_D281del12(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACAGGCACAAACACGCACCTC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	13					0	0	1	0	0
TRMT1L	81627	broad.mit.edu	37	1	185089245	185089245	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:185089245C>G	ENST00000367506.5	-	15	2376	c.2108G>C	c.(2107-2109)aGc>aCc	p.S703T	TRMT1L_ENST00000367504.3_3'UTR|TRMT1L_ENST00000465827.1_5'UTR	NM_001202423.1|NM_030934.4	NP_001189352.1|NP_112196.3	Q7Z2T5	TRM1L_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	703						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	21						CTGGACATGGCTTTCTGACTG	0.448000													29	134					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160453657	160453657	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:160453657C>G	ENST00000356956.1	+	8	1105	c.957C>G	c.(955-957)caC>caG	p.H319Q		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	319					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATGCCTGCCACAGAGATTACC	0.493000													17	114					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6026806	6026806	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:6026806C>T	ENST00000265849.7	-	11	1695	c.1590G>A	c.(1588-1590)caG>caA	p.Q530Q	PMS2_ENST00000382321.4_Intron|PMS2_ENST00000441476.2_Silent_p.Q424Q|PMS2_ENST00000406569.3_Silent_p.Q530Q|PMS2_ENST00000469652.1_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	530					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CCACATGTTCCTGCGAGCCCC	0.552000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				8	298					0	0	1	0	0
WSB1	26118	broad.mit.edu	37	17	25628923	25628923	+	Silent	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:25628923T>C	ENST00000262394.2	+	2	466	c.150T>C	c.(148-150)gcT>gcC	p.A50A	WSB1_ENST00000427287.2_Silent_p.A19A|WSB1_ENST00000578312.1_3'UTR|WSB1_ENST00000348811.2_Intron|WSB1_ENST00000579733.1_Intron|WSB1_ENST00000581185.1_Silent_p.A50A|WSB1_ENST00000583193.1_Intron	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	50					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CATACTTTGCTTGGTCACAAG	0.423000													44	282					0	0	1	0	0
POMGNT2	84892	broad.mit.edu	37	3	43121448	43121448	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr3:43121448C>T	ENST00000344697.2	-	2	1821	c.1476G>A	c.(1474-1476)gcG>gcA	p.A492A	GTDC2_ENST00000441964.1_Silent_p.A492A	NM_032806.4	NP_116195.2																					CATGCACTGACGCCTGGCACC	0.622000													17	64					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83781743	83781743	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:83781743G>T	ENST00000566620.1	+	11	1859	c.1569G>T	c.(1567-1569)tgG>tgT	p.W523C	RP11-298D21.1_ENST00000563981.1_RNA|CDH13_ENST00000428848.3_Missense_Mutation_p.W484C|RP11-298D21.1_ENST00000570056.1_RNA|CDH13_ENST00000268613.10_Missense_Mutation_p.W570C|RP11-298D21.1_ENST00000569165.1_RNA	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	523	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CAGCAGGTTGGCTGAATATTA	0.468000													38	163					2.19358e-23	2.60169e-23	1	1	0
FOXH1	8928	broad.mit.edu	37	8	145699898	145699898	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr8:145699898C>A	ENST00000377317.4	-	3	1399	c.821G>T	c.(820-822)tGg>tTg	p.W274L		NM_003923.2	NP_003914.1	O75593	FOXH1_HUMAN	forkhead box H1	274	SMAD-interaction domain (SID).				axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CAGCTGCCCCCAGAGGGAGGC	0.647000													14	127					0.00244969	0.00256276	1	1	0
SMARCA1	6594	broad.mit.edu	37	X	128645931	128645931	+	Silent	SNP	A	A	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:128645931A>T	ENST00000371122.4	-	6	789	c.660T>A	c.(658-660)gcT>gcA	p.A220A	SMARCA1_ENST00000478420.1_5'UTR|SMARCA1_ENST00000371121.3_Silent_p.A220A|SMARCA1_ENST00000371123.1_Silent_p.A220A	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	220	Helicase ATP-binding.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						AACCAAGCAAAGCAATTGTTT	0.353000													32	408					0	0	1	0	0
ATP6AP1	537	broad.mit.edu	37	X	153662714	153662714	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:153662714G>T	ENST00000369762.2	+	7	906	c.845G>T	c.(844-846)tGg>tTg	p.W282L		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	282					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAGGACCAGTGGGAGGACCTG	0.572000													28	207					5.61819e-17	6.58684e-17	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124856702	124856702	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:124856702G>C	ENST00000356219.3	-	21	2828	c.2673C>G	c.(2671-2673)ctC>ctG	p.L891L	NCOR2_ENST00000429285.2_Silent_p.L873L|NCOR2_ENST00000405201.1_Silent_p.L891L|NCOR2_ENST00000404121.2_Silent_p.L444L|NCOR2_ENST00000397355.1_Silent_p.L874L|NCOR2_ENST00000404621.1_Silent_p.L873L	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	891					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCTGCCTTGAGCGCCCCCT	0.716000													9	120					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244797	56244797	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:56244797C>G	ENST00000332836.2	-	2	427	c.400G>C	c.(400-402)Gaa>Caa	p.E134Q		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	134						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TCATTCAATTCTTTATACTCA	0.398000													6	63					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99947698	99947698	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr13:99947698C>G	ENST00000376414.4	-	2	785	c.702G>C	c.(700-702)gaG>gaC	p.E234D	UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	234					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						CACCAGATTTCTCAGTGAGTG	0.353000													19	190					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146823697	146823697	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:146823697C>A	ENST00000508784.1	-	2	941	c.714G>T	c.(712-714)gaG>gaT	p.E238D	ZNF827_ENST00000379448.4_Missense_Mutation_p.E238D|ZNF827_ENST00000513320.1_Intron			Q17R98	ZN827_HUMAN	zinc finger protein 827	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					AGGAAAAGGACTCAAATCGCA	0.517000													17	51					7.07596e-05	7.47925e-05	1	1	0
SHANK3	85358	broad.mit.edu	37	22	51159540	51159540	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:51159540C>A	ENST00000414786.2	+	21	3464	c.3237C>A	c.(3235-3237)ttC>ttA	p.F1079L	SHANK3_ENST00000262795.3_Missense_Mutation_p.F1109L|SHANK3_ENST00000445220.2_Missense_Mutation_p.F1095L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1109										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GTTCCACCTTCATCCACCCAC	0.741000													5	23					0.014758	0.0152824	1	1	0
SLC5A11	115584	broad.mit.edu	37	16	24895389	24895389	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:24895389A>G	ENST00000347898.3	+	8	1223	c.601A>G	c.(601-603)Atc>Gtc	p.I201V	SLC5A11_ENST00000449109.2_Missense_Mutation_p.I137V|SLC5A11_ENST00000569071.1_Missense_Mutation_p.I137V|SLC5A11_ENST00000545376.1_Missense_Mutation_p.I131V|SLC5A11_ENST00000568579.1_Missense_Mutation_p.I131V|SLC5A11_ENST00000567758.1_Missense_Mutation_p.I166V|SLC5A11_ENST00000565769.1_Missense_Mutation_p.I137V|SLC5A11_ENST00000424767.2_Missense_Mutation_p.I166V|SLC5A11_ENST00000539472.1_Missense_Mutation_p.I137V	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	201					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		GGCTGCTGTGATCTACACGGA	0.602000													107	231					0	0	1	0	0
CNPY2	10330	broad.mit.edu	37	12	56708718	56708718	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:56708718C>G	ENST00000273308.4	-	3	661	c.121G>C	c.(121-123)Gaa>Caa	p.E41Q	RP11-977G19.10_ENST00000549318.1_Missense_Mutation_p.E41Q|CNPY2_ENST00000551720.1_5'UTR	NM_014255.5	NP_055070.1	Q9Y2B0	CNPY2_HUMAN	canopy FGF signaling regulator 2	41	Saposin B-type.					endoplasmic reticulum|integral to plasma membrane	protein binding			large_intestine(2)|lung(2)	4						TGGGCAATTTCCCATTCTAGT	0.537000													3	66					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379171	114379171	+	Silent	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:114379171C>G	ENST00000312719.5	-	5	1479	c.291G>C	c.(289-291)ggG>ggC	p.G97G	RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA|HS3ST5_ENST00000411826.1_Silent_p.G97G			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	97					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding	p.G97G(1)		breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		CTTTCCTCACCCCAATGATAA	0.537000													43	61					0	0	1	0	0
MATN1	4146	broad.mit.edu	37	1	31188053	31188053	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:31188053G>C	ENST00000373765.4	-	6	1346	c.1311C>G	c.(1309-1311)ttC>ttG	p.F437L		NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	437	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TGATGGTCTTGAAGTCAGCCG	0.532000													13	150					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049439	90049439	+	Silent	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:90049439G>T	ENST00000330947.2	+	5	1590	c.1230G>T	c.(1228-1230)ctG>ctT	p.L410L	LRRC8B_ENST00000358200.4_Silent_p.L410L|LRRC8B_ENST00000439853.1_Silent_p.L410L|RP5-1007M22.2_ENST00000443562.1_RNA	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	410						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TTGAGAAACTGAAAAGTAAGC	0.383000													11	113					3.86212e-05	4.12499e-05	1	1	0
SPAG4	6676	broad.mit.edu	37	20	34204074	34204074	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr20:34204074G>C	ENST00000374273.3	+	1	261	c.149G>C	c.(148-150)aGa>aCa	p.R50T		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	50					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			CCCGAGGGCAGAAGAGCCCGG	0.677000													6	18					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48958435	48958435	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:48958435G>A	ENST00000294954.7	-	2	185	c.164C>T	c.(163-165)tCa>tTa	p.S55L	LHCGR_ENST00000344775.3_Missense_Mutation_p.S55L|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.S55L|LHCGR_ENST00000403273.1_Missense_Mutation_p.S55L|LHCGR_ENST00000401907.1_Missense_Mutation_p.S55L	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	55	LRRNT.				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTAGGCAAGTGATCTAGAAAA	0.353000													15	56					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084759	99084759	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:99084759G>C	ENST00000331410.5	+	5	1196	c.926G>C	c.(925-927)gGa>gCa	p.G309A	ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000494186.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATCCATAGTGGAGAAAAACGC	0.393000													8	77					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28854920	28854920	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:28854920C>T	ENST00000422425.2	+	54	3926	c.3882C>T	c.(3880-3882)ttC>ttT	p.F1294F	PLB1_ENST00000541605.1_Silent_p.F270F|PLB1_ENST00000327757.5_Silent_p.F1305F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1305	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TCTCCAGTTTCTCCTACTGGC	0.557000													7	96					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135445703	135445703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:135445703C>T	ENST00000394143.1	+	13	7636	c.7345C>T	c.(7345-7347)Caa>Taa	p.Q2449*	GPR112_ENST00000370652.1_Nonsense_Mutation_p.Q2449*|GPR112_ENST00000287534.4_Nonsense_Mutation_p.Q2247*|GPR112_ENST00000412101.1_Nonsense_Mutation_p.Q2244*|GPR112_ENST00000394141.1_Nonsense_Mutation_p.Q2244*	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2449					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CAAATTGCTTCAAGAACTTCC	0.348000													8	93					0	0	1	0	0
TMEM155	132332	broad.mit.edu	37	4	122682998	122682998	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:122682998A>C	ENST00000337677.5	-	4	599	c.41T>G	c.(40-42)cTa>cGa	p.L14R	TMEM155_ENST00000394396.1_Missense_Mutation_p.L14R|TMEM155_ENST00000394394.1_Missense_Mutation_p.L14R	NM_152399.2	NP_689612.2	Q4W5P6	TM155_HUMAN	transmembrane protein 155	14						extracellular region				breast(1)|lung(5)	6						TTTGGAAATTAGTGCAACAGC	0.333000													10	52					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766390	27766390	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:27766390A>G	ENST00000451261.2	+	5	1777	c.1378A>G	c.(1378-1380)Agt>Ggt	p.S460G		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						TGCTCAATACAGTAAGAGATT	0.463000													7	68					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32751131	32751131	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:32751131G>T	ENST00000333070.4	+	13	1534	c.1434G>T	c.(1432-1434)gaG>gaT	p.E478D	LCK_ENST00000373564.3_Missense_Mutation_p.E455D|LCK_ENST00000336890.5_Missense_Mutation_p.E448D	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	448	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CCAACCCGGAGGTGATTCAGA	0.562000			T	TRB@	T-ALL								13	168					0.000422831	0.000444627	1	1	0
STOML2	30968	broad.mit.edu	37	9	35101478	35101478	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr9:35101478T>G	ENST00000356493.5	-	6	586	c.524A>C	c.(523-525)tAt>tCt	p.Y175S	STOML2_ENST00000452248.2_Intron	NM_013442.1	NP_038470.1	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	175						cytoskeleton	receptor binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	16			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTTGATCTCATAACGGAGGCA	0.572000													90	129					0	0	1	0	0
RPL13	6137	broad.mit.edu	37	16	89628078	89628078	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:89628078C>T	ENST00000393099.3	+	3	588	c.339C>T	c.(337-339)aaC>aaT	p.N113N	RPL13_ENST00000567815.1_Silent_p.N113N|RPL13_ENST00000452368.3_Intron|RPL13_ENST00000311528.5_Silent_p.N113N	NM_033251.2	NP_150254.1	P26373	RL13_HUMAN	ribosomal protein L13	113					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome			lung(3)|skin(1)|upper_aerodigestive_tract(2)	6		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		TGCAGGCCAACGTGCAGCGGC	0.617000													16	32					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508672	37508672	+	Silent	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr10:37508672T>C	ENST00000374660.1	+	40	4320	c.4221T>C	c.(4219-4221)gcT>gcC	p.A1407A	ANKRD30A_ENST00000602533.1_Silent_p.A1288A|ANKRD30A_ENST00000361713.1_Silent_p.A1288A			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1344						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATAAGAAAGCTGACAACAAAA	0.318000													6	27					0	0	1	0	0
GAGE1	2543	broad.mit.edu	37	X	49369626	49369626	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:49369626G>C	ENST00000381709.2	+	5	468	c.357G>C	c.(355-357)caG>caC	p.Q119H	GAGE1_ENST00000381700.6_Intron			Q13065	GAGE1_HUMAN	G antigen 1	119					cellular defense response							Ovarian(276;0.236)					atgttgcccagactggGATTC	0.408000													5	52					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974388	49974388	+	Silent	SNP	T	T	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:49974388T>A	ENST00000555099.1	+	1	446	c.414T>A	c.(412-414)gtT>gtA	p.V138V		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						AGCAGCATGTTTGTAGCCTGC	0.473000													9	124					0	0	1	0	0
ADARB1	104	broad.mit.edu	37	21	46642091	46642091	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr21:46642091C>T	ENST00000539173.1	+	12	2640	c.2205C>T	c.(2203-2205)gaC>gaT	p.D735D	ADARB1_ENST00000348831.4_Silent_p.D695D|ADARB1_ENST00000437626.1_3'UTR|ADARB1_ENST00000360697.3_Silent_p.D735D|ADARB1_ENST00000389863.4_Intron	NM_015833.3	NP_056648.1	P78563	RED1_HUMAN	adenosine deaminase, RNA-specific, B1	735	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(1)	17				Colorectal(79;0.115)		CCGAGCAGGACCAGTTCTCAC	0.652000													5	64					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18858159	18858159	+	Nonsense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:18858159C>A	ENST00000266505.7	-	7	1068	c.805G>T	c.(805-807)Gga>Tga	p.G269*	PLCZ1_ENST00000541695.1_Nonsense_Mutation_p.G132*|PLCZ1_ENST00000538330.1_Nonsense_Mutation_p.G10*|PLCZ1_ENST00000539875.1_Nonsense_Mutation_p.G76*|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000447925.2_Nonsense_Mutation_p.G267*|PLCZ1_ENST00000435379.1_Nonsense_Mutation_p.G74*			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	269	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAGGACTCTCCAAAAGTAGCC	0.398000													23	121					3.08376e-08	3.41895e-08	1	1	0
DNAH7	56171	broad.mit.edu	37	2	196737106	196737106	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:196737106G>C	ENST00000312428.6	-	40	6601	c.6501C>G	c.(6499-6501)ctC>ctG	p.L2167L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2167	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GAGTAGGCAAGAGATTCTTCA	0.358000													7	143					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64496353	64496353	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:64496353G>A	ENST00000377494.1	-	14	2675	c.1753C>T	c.(1753-1755)Cga>Tga	p.R585*	RASGRP2_ENST00000377497.3_Nonsense_Mutation_p.R585*|RASGRP2_ENST00000394432.3_Nonsense_Mutation_p.R585*|RASGRP2_ENST00000354024.3_Nonsense_Mutation_p.R585*			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	585					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTGGAGCCTCGCCTGCCAGGG	0.632000													23	29					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233245021	233245021	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:233245021G>A	ENST00000392027.2	+	6	1052	c.783G>A	c.(781-783)gcG>gcA	p.A261A	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	261				AK -> GE (in Ref. 6; AAA51706).		anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		AATGGCTGGCGAAGCGCCAGG	0.652000													30	261					0	0	1	0	0
RAPGEFL1	51195	broad.mit.edu	37	17	38346893	38346893	+	Splice_Site	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:38346893T>C	ENST00000436615.3	+	8	1086	c.594_splice	c.e8-1	p.V199_splice	RAPGEFL1_ENST00000264644.6_Splice_Site_p.V199_splice|RAPGEFL1_ENST00000544503.1_Splice_Site_p.V248_splice|RAPGEFL1_ENST00000456989.2_Splice_Site_p.V254_splice|RAPGEFL1_ENST00000540388.1_3'UTR	NM_016339.3	NP_057423.1	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor (GEF)-like 1	405					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						TGCCACCAGGTGCCCCTCCCC	0.642000													9	212					0	0	1	0	0
RNF113A	7737	broad.mit.edu	37	X	119005489	119005489	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:119005489G>A	ENST00000371442.2	-	1	302	c.88C>T	c.(88-90)Cgc>Tgc	p.R30C	NDUFA1_ENST00000371437.4_5'UTR	NM_006978.2	NP_008909.1	O15541	R113A_HUMAN	ring finger protein 113A	30							nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(6)	15						CGCTTTCTGCGTCCAGCAGCC	0.597000													43	264					0	0	1	0	0
SLC22A1	6580	broad.mit.edu	37	6	160560787	160560787	+	Silent	SNP	G	G	A	rs142714915		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:160560787G>A	ENST00000366963.4	+	7	1311	c.1164G>A	c.(1162-1164)ccG>ccA	p.P388P	SLC22A1_ENST00000457470.2_Silent_p.P388P|SLC22A1_ENST00000324965.4_Silent_p.P388P	NM_003057.2|NM_153187.1	NP_003048.1|NP_694857.1	O15245	S22A1_HUMAN	solute carrier family 22 (organic cation transporter), member 1	388						basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding		SLC22A1/CUTA(2)	breast(1)|endometrium(3)|large_intestine(3)|lung(13)|upper_aerodigestive_tract(1)	21		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TCGAAATCCCGGGGGCCTTCA	0.587000													10	72					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109697785	109697785	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:109697785G>A	ENST00000465301.2	+	3	4186	c.3940G>A	c.(3940-3942)Gag>Aag	p.E1314K	RGAG1_ENST00000540313.1_Missense_Mutation_p.E1314K	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1314										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						GCTGGCTGAAGAGAAGGATTC	0.542000													18	125					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300463	88300463	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:88300463G>T	ENST00000418177.2	-	8	2755	c.2388C>A	c.(2386-2388)aaC>aaA	p.N796K	GRM5_ENST00000455756.2_Missense_Mutation_p.N796K|GRM5_ENST00000305432.5_Missense_Mutation_p.N796K|GRM5_ENST00000393297.1_Missense_Mutation_p.N796K|GRM5_ENST00000305447.4_Missense_Mutation_p.N796K			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	796					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TGATTTTGTAGTTGCTGCCAA	0.483000													26	171					3.01185e-09	3.35747e-09	1	1	0
SLC44A1	23446	broad.mit.edu	37	9	108126955	108126955	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr9:108126955C>A	ENST00000374720.3	+	10	1454	c.1207C>A	c.(1207-1209)Cag>Aag	p.Q403K	SLC44A1_ENST00000343170.7_Missense_Mutation_p.Q195K|SLC44A1_ENST00000374723.1_Missense_Mutation_p.Q403K|SLC44A1_ENST00000374724.1_Missense_Mutation_p.Q403K	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	403						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	TCTAGCATGTCAGCAGATGAC	0.438000													20	141					7.45023e-12	8.53846e-12	1	1	0
CRK	1398	broad.mit.edu	37	17	1359352	1359352	+	Silent	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:1359352C>A	ENST00000300574.2	-	1	200	c.60G>T	c.(58-60)cgG>cgT	p.R20R	CRK_ENST00000574295.1_Silent_p.R20R|CRK_ENST00000398970.5_Silent_p.R20R|CRK_ENST00000572145.1_Intron	NM_016823.3	NP_058431.2	P46108	CRK_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog	20	SH2.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)	9				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		CCGCCTCCTGCCGACTCAACC	0.701000													3	40					1	1	1	1	0
TRPM2	7226	broad.mit.edu	37	21	45860715	45860715	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr21:45860715C>T	ENST00000397928.1	+	31	4758	c.4313C>T	c.(4312-4314)gCc>gTc	p.A1438V	TRPM2_ENST00000397932.2_Missense_Mutation_p.A1488V|TRPM2_ENST00000300482.5_Missense_Mutation_p.A1438V|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.A1384V	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1438	Nudix hydrolase.		A -> S (in dbSNP:rs45578242).			integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACGGACAATGCCTGGATCGAG	0.627000													12	163					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40328187	40328187	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:40328187G>C	ENST00000264661.3	-	5	1046	c.714C>G	c.(712-714)ttC>ttG	p.F238L	KCNH4_ENST00000607371.1_Missense_Mutation_p.F238L	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	238					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCGCAACGTAGAAGGTGGCAA	0.607000													12	239					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1536942	1536942	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:1536942G>A	ENST00000534940.1	-	11	1497	c.1272C>T	c.(1270-1272)gaC>gaT	p.D424D	ASMTL_ENST00000381317.3_Silent_p.D482D|ASMTL_ENST00000381333.4_Silent_p.D466D|ASMTL_ENST00000416733.2_Silent_p.D406D	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	482	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGTCTGGGAGGTCAAACACAG	0.632000													6	98					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112058796	112058796	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:112058796C>T	ENST00000371959.3	-	2	1181	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	AMOT_ENST00000304758.1_5'UTR|AMOT_ENST00000524145.1_Silent_p.Q394Q|AMOT_ENST00000371958.1_Silent_p.Q162Q|AMOT_ENST00000371962.1_Silent_p.Q162Q	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	394					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q394Q(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gctgctgctgctgttgttggt	0.582000													4	76					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31254048	31254048	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:31254048G>C	ENST00000407793.2	+	20	2287	c.2036G>C	c.(2035-2037)aGa>aCa	p.R679T	DDX11_ENST00000545668.1_Missense_Mutation_p.R679T|DDX11_ENST00000350437.4_Missense_Mutation_p.R679T|DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000542838.1_Missense_Mutation_p.R679T|DDX11_ENST00000228264.6_Missense_Mutation_p.R653T	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	679					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TTCCAGAAAAGAGAGCTGCCT	0.617000										Multiple Myeloma(12;0.14)			6	133					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53994554	53994554	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:53994554G>A	ENST00000396403.4	+	4	1196	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AACCTTTCAAGTGTAATGAGT	0.418000													34	140					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31234219	31234219	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr15:31234219G>A	ENST00000435680.1	-	16	1885	c.1788C>T	c.(1786-1788)atC>atT	p.I596I	FAN1_ENST00000362065.4_3'UTR|MTMR10_ENST00000425768.1_3'UTR|MTMR10_ENST00000314404.8_Intron	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	596	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CTTGGTCACTGATGATTCCAT	0.413000													11	186					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21897268	21897268	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr14:21897268G>A	ENST00000399982.2	-	2	1134	c.1070C>T	c.(1069-1071)cCa>cTa	p.P357L	CHD8_ENST00000430710.3_Missense_Mutation_p.P78L|CHD8_ENST00000557364.1_Missense_Mutation_p.P357L|CHD8_ENST00000555962.1_Intron	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	357	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CGATGATGGTGGTTGTGGTAC	0.562000													13	193					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			77	111					0	0	1	0	0
ACTRT3	84517	broad.mit.edu	37	3	169485232	169485232	+	Silent	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr3:169485232T>C	ENST00000330368.2	-	2	1481	c.1107A>G	c.(1105-1107)caA>caG	p.Q369Q		NM_032487.4	NP_115876.3	Q9BYD9	ARPM1_HUMAN	actin-related protein T3	369						cytoplasm|cytoskeleton											AGAAGCATCTTTGGTGTACTA	0.378000													9	83					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35434477	35434477	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:35434477C>T	ENST00000439785.1	+	5	1054	c.610C>T	c.(610-612)Cca>Tca	p.P204S	ZNF30_ENST00000303586.7_Missense_Mutation_p.P204S|ZNF30_ENST00000426813.2_Missense_Mutation_p.P122S|ZNF30_ENST00000601142.1_Missense_Mutation_p.P203S|ZNF30_ENST00000601957.1_3'UTR	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TGGTGAGAAGCCACTCAAATG	0.413000													11	47					0	0	1	0	0
MS4A1	931	broad.mit.edu	37	11	60233571	60233571	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:60233571C>A	ENST00000534668.1	+	5	803	c.514C>A	c.(514-516)Ccc>Acc	p.P172T	MS4A1_ENST00000532073.1_Missense_Mutation_p.P172T|MS4A1_ENST00000345732.4_Missense_Mutation_p.P172T|MS4A1_ENST00000389939.2_Missense_Mutation_p.P172T|MS4A1_ENST00000528313.1_Intron	NM_152866.2	NP_690605.1	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member 1	172	Epitope 3 (recognized by antibodies, including Rituximab).				B cell activation|immune response	integral to plasma membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	ACCAGCTAATCCCTCTGAGAA	0.348000													15	77					1.15088e-07	1.26908e-07	1	1	0
ESX1	80712	broad.mit.edu	37	X	103497486	103497486	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:103497486T>A	ENST00000372588.4	-	3	613	c.530A>T	c.(529-531)aAt>aTt	p.N177I		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	177					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						TTCAGTCAAATTCAGGCGTGC	0.408000													34	326					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30695427	30695427	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr8:30695427G>A	ENST00000256246.2	-	3	7298	c.7224C>T	c.(7222-7224)tgC>tgT	p.C2408C		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2408								p.C2408*(1)		NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACTTTGATGCGCAAGTGTCTT	0.368000													6	170					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135113555	135113555	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr10:135113555T>A	ENST00000368563.2	-	3	569	c.213A>T	c.(211-213)aaA>aaT	p.K71N	TUBGCP2_ENST00000417178.2_5'UTR|TUBGCP2_ENST00000252936.3_Missense_Mutation_p.K71N|TUBGCP2_ENST00000543663.1_Missense_Mutation_p.K71N|TUBGCP2_ENST00000470829.1_5'UTR	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	71					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		TATTTTTAGATTTCAGTTCAT	0.433000													6	68					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110762855	110762855	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:110762855T>A	ENST00000451085.1	+	4	1073	c.27T>A	c.(25-27)caT>caA	p.H9Q	IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000447215.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.H9Q|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000489381.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.H9Q|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000331762.3_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	9						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TCCGAATTCATGTGCTACTTG	0.428000													28	116					0	0	1	0	0
DARS2	55157	broad.mit.edu	37	1	173799835	173799835	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:173799835C>T	ENST00000361951.4	+	4	1059	c.332C>T	c.(331-333)cCt>cTt	p.P111L	DARS2_ENST00000239457.5_5'UTR	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	111					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	TGTGAAGCCCCTGTGGAATCT	0.428000													10	117					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22390364	22390364	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:22390364G>C	ENST00000334304.5	-	19	3199	c.2930C>G	c.(2929-2931)tCt>tGt	p.S977C	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	977					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				CAGAGACAAAGACATTGAATC	0.453000													4	69					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109153058	109153058	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:109153058C>G	ENST00000261483.4	+	13	3080	c.2028C>G	c.(2026-2028)ttC>ttG	p.F676L		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	676					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGCAAGTGTTCTCTGCTTCAG	0.443000													19	131					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404033	10404033	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:10404033G>C	ENST00000226207.5	-	28	3869	c.3775C>G	c.(3775-3777)Caa>Gaa	p.Q1259E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1259						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TCACTCAGTTGATCTTCTAGA	0.473000													5	135					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54424357	54424357	+	Missense_Mutation	SNP	A	A	T	rs77495563	by1000genomes	TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:54424357A>T	ENST00000334206.5	-	7	962	c.786T>A	c.(784-786)aaT>aaA	p.N262K	CDC20B_ENST00000381375.2_Missense_Mutation_p.N262K|CDC20B_ENST00000322374.6_Missense_Mutation_p.N262K|CDC20B_ENST00000296733.1_Missense_Mutation_p.N262K			Q86Y33	CD20B_HUMAN	cell division cycle 20B	262										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TTTCAATCCCATTGTGGTTCT	0.438000													17	69					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367481	234367481	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:234367481G>T	ENST00000366618.3	+	3	747	c.602G>T	c.(601-603)cGa>cTa	p.R201L	SLC35F3_ENST00000366617.3_Missense_Mutation_p.R132L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	132					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GTGAAGCAGCGATACAGGTAG	0.597000													20	110					5.35267e-07	5.83927e-07	1	1	0
HR	55806	broad.mit.edu	37	8	21977320	21977320	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr8:21977320G>A	ENST00000381418.4	-	14	4410	c.2930C>T	c.(2929-2931)cCg>cTg	p.P977L	HR_ENST00000312841.8_Missense_Mutation_p.P977L	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	977	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGCAAGGCCCGGTGGGAGGTA	0.627000													4	58					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133876489	133876489	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:133876489G>A	ENST00000285928.2	+	12	1486	c.1417G>A	c.(1417-1419)Gaa>Aaa	p.E473K		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	473	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						CGTTTTTGATGAAATGGTGAA	0.343000													22	60					0	0	1	0	0
FAM9B	171483	broad.mit.edu	37	X	9001087	9001087	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:9001087G>A	ENST00000362066.3	-	1	264	c.76C>T	c.(76-78)Caa>Taa	p.Q26*	FAM9B_ENST00000428477.1_5'UTR|FAM9B_ENST00000327220.5_5'UTR			Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	0						nucleus				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|urinary_tract(1)	11		Hepatocellular(5;0.219)				GTGGCTGGTTGTCCTGGGAAG	0.572000													7	61					0	0	1	0	0
SOCS5	9655	broad.mit.edu	37	2	46986247	46986247	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:46986247C>T	ENST00000306503.5	+	2	750	c.578C>T	c.(577-579)aCt>aTt	p.T193I	SOCS5_ENST00000394861.2_Missense_Mutation_p.T193I	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	193					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CCCATGAGAACTTACAGCAAG	0.433000													5	125					0	0	1	0	0
GPR78	27201	broad.mit.edu	37	4	8584262	8584262	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:8584262C>T	ENST00000382487.4	+	2	1090	c.673C>T	c.(673-675)Cgg>Tgg	p.R225W	GPR78_ENST00000509216.1_3'UTR	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	225					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						CCACAGTGTGCGGCAGCGCTG	0.632000													8	89					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166571968	166571968	+	Silent	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:166571968C>A	ENST00000296946.2	-	9	1611	c.1143G>T	c.(1141-1143)gcG>gcT	p.A381A	T_ENST00000366871.3_Silent_p.A323A	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	381					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTGTGTAGTGCGCGGGGGAGC	0.706000									Chordoma, Familial Clustering of				12	93					4.36969e-10	4.92496e-10	1	1	0
BRCA1	672	broad.mit.edu	37	17	41251869	41251869	+	Missense_Mutation	SNP	G	G	C	rs80357887		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:41251869G>C	ENST00000357654.3	-	7	588	c.470C>G	c.(469-471)tCt>tGt	p.S157C	BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000471181.2_Missense_Mutation_p.S157C|BRCA1_ENST00000468300.1_Missense_Mutation_p.S157C|BRCA1_ENST00000493795.1_Missense_Mutation_p.S110C|BRCA1_ENST00000351666.3_Missense_Mutation_p.S157C|BRCA1_ENST00000346315.3_Missense_Mutation_p.S157C|BRCA1_ENST00000354071.3_Missense_Mutation_p.S157C|BRCA1_ENST00000352993.3_Missense_Mutation_p.S157C|BRCA1_ENST00000491747.2_Missense_Mutation_p.S157C|BRCA1_ENST00000309486.4_5'UTR|BRCA1_ENST00000586385.1_Intron	NM_007294.3	NP_009225.1	P38398	BRCA1_HUMAN	breast cancer 1, early onset	157					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCCAAGGTTAGAGAGTTGGAC	0.433000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			7	196					0	0	1	0	0
STRBP	55342	broad.mit.edu	37	9	125920382	125920382	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr9:125920382G>C	ENST00000447404.2	-	10	1258	c.954C>G	c.(952-954)gcC>gcG	p.A318A	STRBP_ENST00000348403.5_Silent_p.A318A|STRBP_ENST00000360998.3_Silent_p.A304A			Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	318	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(6)|prostate(1)|skin(2)	26						TCTGGCCAAAGGCTGATAGTC	0.388000													32	101					0	0	1	0	0
NEK6	10783	broad.mit.edu	37	9	127113174	127113174	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr9:127113174G>A	ENST00000373600.3	+	11	1207	c.992G>A	c.(991-993)gGa>gAa	p.G331E	NEK6_ENST00000320246.5_Missense_Mutation_p.G297E|NEK6_ENST00000546191.1_Missense_Mutation_p.G297E|NEK6_ENST00000373603.1_Missense_Mutation_p.G297E|NEK6_ENST00000540326.1_Missense_Mutation_p.G315E|NEK6_ENST00000545174.1_Missense_Mutation_p.G297E|NEK6_ENST00000394199.2_Missense_Mutation_p.G331E|NEK6_ENST00000539416.1_Missense_Mutation_p.G322E	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	297					apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						CCTGACATCGGATACGTGCAC	0.542000													4	50					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190213	66190213	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:66190213G>T	ENST00000311034.2	+	4	675	c.499G>T	c.(499-501)Gtg>Ttg	p.V167L		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	167					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CAACAAACTCGTGCTTATTCG	0.562000													29	102					3.80469e-20	4.48646e-20	1	1	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													3	52					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110409232	110409232	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:110409232G>C	ENST00000420978.2	+	4	1662	c.240G>C	c.(238-240)caG>caC	p.Q80H	TSLP_ENST00000344895.3_Missense_Mutation_p.Q80H|TSLP_ENST00000379706.4_5'UTR			Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin	80						extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTGAAATCCAGAGCCTAACCT	0.493000													8	214					0	0	1	0	0
GUCA1A	2978	broad.mit.edu	37	6	42146546	42146546	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:42146546C>T	ENST00000394237.1	+	5	1334	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C	GUCA1A_ENST00000541991.1_Missense_Mutation_p.R120C|GUCA1A_ENST00000053469.4_Missense_Mutation_p.R120C|GUCA1A_ENST00000372958.1_Missense_Mutation_p.R120C			P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	120	EF-hand 3.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCAGGCCATTCGCGCCATTAA	0.582000													81	309					0	0	1	0	0
LHX3	8022	broad.mit.edu	37	9	139091560	139091560	+	Missense_Mutation	SNP	C	C	T	rs61735423		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr9:139091560C>T	ENST00000371746.3	-	3	551	c.433G>A	c.(433-435)Gtg>Atg	p.V145M	LHX3_ENST00000371748.5_Missense_Mutation_p.V140M	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	140					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GCCTTGCACACGAGCCGGCTG	0.632000													6	62					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40485908	40485908	+	Splice_Site	SNP	C	C	G	rs113512148		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:40485908C>G	ENST00000264657.5	-	9	1269		c.e9+1		STAT3_ENST00000585517.1_Splice_Site|STAT3_ENST00000404395.3_Splice_Site|STAT3_ENST00000588969.1_Splice_Site|STAT3_ENST00000389272.3_Splice_Site	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)						cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TGCTAAATTACCTTTTCATTA	0.488000									Hyperimmunoglobulin E Recurrent Infection Syndrome				4	67					0	0	1	0	0
TAC1	6863	broad.mit.edu	37	7	97363588	97363588	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:97363588G>C	ENST00000319273.5	+	4	546	c.249G>C	c.(247-249)ctG>ctC	p.L83L	TAC1_ENST00000350485.4_Silent_p.L83L|TAC1_ENST00000346867.4_Intron	NM_003182.2	NP_003173.1	P20366	TKN1_HUMAN	tachykinin, precursor 1	83					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space				large_intestine(4)|lung(6)|urinary_tract(1)	11	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	AAGTGGCCCTGTTAAAGGCTC	0.343000													5	27					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170493719	170493719	+	Missense_Mutation	SNP	A	A	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:170493719A>T	ENST00000260970.3	+	14	2171	c.1951A>T	c.(1951-1953)Agc>Tgc	p.S651C	PPIG_ENST00000409714.3_Missense_Mutation_p.S636C|PPIG_ENST00000448752.2_Missense_Mutation_p.S651C	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	651					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AGAGAGTAAGAGCTCACACAG	0.388000													4	34					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			5	89					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7669666	7669666	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:7669666C>G	ENST00000572933.1	+	22	5002	c.3542C>G	c.(3541-3543)tCt>tGt	p.S1181C	DNAH2_ENST00000389173.2_Missense_Mutation_p.S1181C			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1181	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GGATACATGTCTGCCTTAGAC	0.547000													9	48					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7915153	7915153	+	Silent	SNP	G	G	A	rs138052675		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr20:7915153G>A	ENST00000378789.3	-	2	318	c.267C>T	c.(265-267)gaC>gaT	p.D89D		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	89	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAAGCTCGCCGTCCACATGAG	0.522000													21	114					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58371061	58371061	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:58371061G>C	ENST00000339656.5	+	3	1463	c.1281G>C	c.(1279-1281)caG>caC	p.Q427H	ZNF814_ENST00000597832.1_Intron|ZNF587_ENST00000423137.1_Missense_Mutation_p.Q426H|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF587_ENST00000419854.1_Missense_Mutation_p.Q384H	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CTGAACACCAGAGACTTCACA	0.453000													5	109					0	0	1	0	0
NEIL1	79661	broad.mit.edu	37	15	75641338	75641338	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr15:75641338C>G	ENST00000564784.1	+	3	721	c.92C>G	c.(91-93)tCt>tGt	p.S31C	NEIL1_ENST00000567959.1_Intron|NEIL1_ENST00000569035.1_Missense_Mutation_p.S31C|NEIL1_ENST00000355059.4_Missense_Mutation_p.S31C			Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1 (E. coli)	31					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)	13						GAGAAGTCCTCTGTCAGCCGC	0.647000								Base excision repair (BER), DNA glycosylases					7	69					0	0	1	0	0
PIGA	5277	broad.mit.edu	37	X	15339766	15339766	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:15339766G>C	ENST00000333590.4	-	6	1401	c.1317C>G	c.(1315-1317)ctC>ctG	p.L439L	PIGA_ENST00000542278.1_Silent_p.L205L|PIGA_ENST00000428964.1_Silent_p.L124L|PIGA_ENST00000482148.1_5'UTR	NM_002641.3	NP_002632.1	P37287	PIGA_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class A	439					C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Hepatocellular(33;0.183)					TCAAGAAAATGAGGAAGAGGA	0.443000													7	278					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10550742	10550742	+	Splice_Site	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:10550742C>T	ENST00000583535.1	-	9	824	c.735_splice	c.e9-1	p.G246_splice	MYH3_ENST00000226209.7_Splice_Site_p.G246_splice	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	246	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GATGAACTTGCCCTGTATGGG	0.488000													9	101					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23603146	23603146	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:23603146G>C	ENST00000305877.8	+	3	2222	c.1471G>C	c.(1471-1473)Gac>Cac	p.D491H	BCR_ENST00000359540.3_Missense_Mutation_p.D491H	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	491					regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						GAGTGAGCTGGACTTGGAAAA	0.562000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								6	68					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049344	90049344	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:90049344C>T	ENST00000330947.2	+	5	1495	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	LRRC8B_ENST00000358200.4_Missense_Mutation_p.L379F|LRRC8B_ENST00000439853.1_Missense_Mutation_p.L379F|RP5-1007M22.2_ENST00000443562.1_RNA	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	379						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTATGATCCTCTTTATTCCAA	0.398000													10	116					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105509462	105509462	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr8:105509462G>T	ENST00000276654.5	-	5	1426	c.1318C>A	c.(1318-1320)Cca>Aca	p.P440T	LRP12_ENST00000424843.2_Missense_Mutation_p.P421T	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	440	LDL-receptor class A 4.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGCCATTTGGGCAATGATTC	0.403000													5	100					5.18039e-06	5.5621e-06	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25307523	25307523	+	RNA	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr15:25307523T>G	ENST00000549804.2	+	0	397				SNORD116-5_ENST00000384462.1_RNA																							TTGGAAAAGCTGAACAAAATG	0.512000													21	135					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195492166	195492166	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr3:195492166G>A	ENST00000463781.3	-	9	14232	c.13773C>T	c.(13771-13773)gaC>gaT	p.D4591D	MUC4_ENST00000346145.4_Silent_p.D355D|MUC4_ENST00000475231.1_Silent_p.D4539D|MUC4_ENST00000349607.4_Silent_p.D304D	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1348					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGAATCGTAAGTCCCGTCGTC	0.647000													6	74					0	0	1	0	0
MC2R	4158	broad.mit.edu	37	18	13885208	13885208	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr18:13885208C>G	ENST00000327606.3	-	2	490	c.310G>C	c.(310-312)Gac>Cac	p.D104H		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	104					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	TCGATGATGTCATCGGCTGTG	0.498000													4	72					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926824	72926824	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:72926824G>A	ENST00000331427.4	+	6	1186	c.1094G>A	c.(1093-1095)cGc>cAc	p.R365H	OTOP2_ENST00000580223.1_Missense_Mutation_p.R365H	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	365						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					AACCCCACGCGCACTCTGGAC	0.617000													4	96					0	0	1	0	0
HCCS	3052	broad.mit.edu	37	X	11139855	11139855	+	Silent	SNP	C	C	T	rs139955716	byFrequency	TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:11139855C>T	ENST00000321143.4	+	7	934	c.732C>T	c.(730-732)gaC>gaT	p.D244D	ARHGAP6_ENST00000534860.1_Intron|HCCS_ENST00000380762.4_Silent_p.D244D|HCCS_ENST00000380763.3_Silent_p.D244D	NM_001122608.2|NM_001171991.2|NM_005333.4	NP_001116080.1|NP_001165462.1|NP_005324.3	P53701	CCHL_HUMAN	holocytochrome c synthase	244					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)	7						CCATCCTGGACGTCCGTCCTG	0.448000													11	113					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132534871	132534871	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:132534871G>A	ENST00000265342.7	-	16	2694	c.2445C>T	c.(2443-2445)ctC>ctT	p.L815L	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	815						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCCATTGATGAGGAACAGTG	0.592000													24	43					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614656	247614656	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:247614656A>C	ENST00000318749.6	-	1	652	c.629T>G	c.(628-630)tTc>tGc	p.F210C		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CACCAACACGAAGAAGGCCAC	0.567000													7	50					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11111151	11111151	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:11111151A>G	ENST00000304623.8	-	14	2471	c.2282T>C	c.(2281-2283)gTt>gCt	p.V761A	CTNND2_ENST00000359640.2_Missense_Mutation_p.V761A|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.V328A|CTNND2_ENST00000511377.1_Missense_Mutation_p.V670A|CTNND2_ENST00000503622.1_Missense_Mutation_p.V424A	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	761					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						ACAGTTTTCAACGGTCTGCAG	0.522000													9	256					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30128538	30128538	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr6:30128538T>G	ENST00000449742.2	-	1	173	c.98A>C	c.(97-99)cAc>cCc	p.H33P	TRIM10_ENST00000376704.3_Missense_Mutation_p.H33P	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	33						cytoplasm	zinc ion binding			ovary(1)	1						GCAGAAGTTGTGGCCGCAGTC	0.607000													6	142					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56168498	56168498	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr5:56168498C>A	ENST00000399503.3	+	8	1454	c.1454C>A	c.(1453-1455)cCt>cAt	p.P485H		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	485					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AATAGAGAACCTTTAATATGT	0.269000													14	41					2.48551e-13	2.88093e-13	1	1	0
DMD	1756	broad.mit.edu	37	X	32407666	32407666	+	Silent	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:32407666T>C	ENST00000357033.4	-	32	4676	c.4470A>G	c.(4468-4470)acA>acG	p.T1490T	DMD_ENST00000378677.2_Silent_p.T1486T	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1490	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCACACTCTTTGTTTCCAATG	0.403000													64	105					0	0	1	0	0
SPAST	6683	broad.mit.edu	37	2	32366999	32366999	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:32366999C>G	ENST00000315285.3	+	13	1645	c.1520C>G	c.(1519-1521)tCt>tGt	p.S507C	SPAST_ENST00000345662.1_Missense_Mutation_p.S475C	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	507	Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GTATATGTGTCTTTACCAAAT	0.313000													4	25					0	0	1	0	0
NIFK	84365	broad.mit.edu	37	2	122494355	122494355	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:122494355C>G	ENST00000285814.4	-	1	144	c.72G>C	c.(70-72)aaG>aaC	p.K24N		NM_032390.4	NP_115766.3	Q9BYG3	MK67I_HUMAN		24					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12						GCGCCACCTCCTTTTGAAACT	0.627000													12	112					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	591448	591448	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:591448G>T	ENST00000264555.5	+	5	613	c.485G>T	c.(484-486)gGt>gTt	p.G162V	PHRF1_ENST00000533464.1_Missense_Mutation_p.G158V|PHRF1_ENST00000416188.2_Missense_Mutation_p.G162V|PHRF1_ENST00000413872.2_Missense_Mutation_p.G161V	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	162							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GCTCAATTTGGTGGTAAAATC	0.468000													3	21					6.4e-05	6.8e-05	1	1	0
UNC45B	146862	broad.mit.edu	37	17	33491145	33491145	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:33491145G>A	ENST00000268876.5	+	9	1208	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	UNC45B_ENST00000433649.1_Missense_Mutation_p.E371K|UNC45B_ENST00000394570.2_Missense_Mutation_p.E371K|UNC45B_ENST00000591048.1_Missense_Mutation_p.E371K|UNC45B_ENST00000378449.1_Missense_Mutation_p.E371K	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	371					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				CTGTGACCCGGAGCGCGATCA	0.537000													14	360					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970548	101970548	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:101970548G>C	ENST00000543253.1	+	5	1670	c.751G>C	c.(751-753)Gag>Cag	p.E251Q	GPRASP2_ENST00000535209.1_Missense_Mutation_p.E251Q|GPRASP2_ENST00000332262.5_Missense_Mutation_p.E251Q	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GCCCAGGGAAGAGTCCAATAC	0.522000													10	261					0	0	1	0	0
MEG8	79104	broad.mit.edu	37	14	101364294	101364294	+	RNA	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr14:101364294C>G	ENST00000458974.1	+	0	38					NR_003080.1																						aacaaaagatcatgattaatc	0.333000													13	80					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130930	45130930	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr20:45130930C>T	ENST00000457685.2	-	6	2257	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	ZNF334_ENST00000347606.4_Missense_Mutation_p.E350K|ZNF334_ENST00000593880.1_Missense_Mutation_p.E373K			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TCCTTGCATTCGTAAGGCTTC	0.438000													24	206					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437940	120437940	+	Silent	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:120437940C>G	ENST00000369400.1	-	1	1178	c.1020G>C	c.(1018-1020)ctG>ctC	p.L340L		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	340	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CAGCATGACCCAGCTCATGAG	0.458000													36	139					0	0	1	0	0
XCL1	6375	broad.mit.edu	37	1	168550291	168550291	+	Splice_Site	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:168550291T>C	ENST00000367818.3	+	3	343	c.176_splice	c.e3-1	p.F60_splice		NM_002995.2	NP_002986.1	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	60					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity			kidney(2)|lung(7)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.208)					GCGTTACAGTTTTATTACCAA	0.463000													3	65					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026871	62026871	+	Silent	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:62026871G>A	ENST00000435607.1	-	15	2947	c.2871C>T	c.(2869-2871)ctC>ctT	p.L957L	SCN4A_ENST00000578147.1_Silent_p.L957L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	957					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCCCATCATAGAGAGGCTGCG	0.642000													5	28					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306388	58306388	+	Missense_Mutation	SNP	T	T	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr15:58306388T>C	ENST00000249750.4	-	2	976	c.209A>G	c.(208-210)cAa>cGa	p.Q70R	ALDH1A2_ENST00000558231.1_Missense_Mutation_p.Q41R|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.Q49R|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.Q70R	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	70					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GTCTGCTTCTTGAACTTCACA	0.423000													16	74					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858418	43858418	+	RNA	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:43858418C>A	ENST00000378009.4	+	0	295				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCAGGAGCCCCGCGTCACTGA	0.647000													7	78					0.0293803	0.0301185	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168106970	168106970	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:168106970T>A	ENST00000409195.1	+	9	9157	c.9068T>A	c.(9067-9069)cTt>cAt	p.L3023H	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.L2801H|XIRP2_ENST00000295237.9_Missense_Mutation_p.L3023H	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2848					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAGATATGCTTGTGTCCTAT	0.343000													15	110					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394734	164394734	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:164394734G>C	ENST00000280605.3	-	1	313	c.153C>G	c.(151-153)gtC>gtG	p.V51V		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	51						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGAAGAAGAGGACAGACACGA	0.577000													6	33					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15967384	15967384	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:15967384G>A	ENST00000268712.3	-	35	5476	c.5219C>T	c.(5218-5220)cCa>cTa	p.P1740L	NCOR1_ENST00000395857.3_Missense_Mutation_p.P324L|NCOR1_ENST00000395851.1_Missense_Mutation_p.P1756L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1740	Interaction with C1D (By similarity).|Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCACTGACCTGGCCGCAGGTA	0.537000													10	138					0	0	1	0	0
FBLN7	129804	broad.mit.edu	37	2	112944954	112944954	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr2:112944954C>G	ENST00000331203.2	+	8	1462	c.1191C>G	c.(1189-1191)atC>atG	p.I397M	FBLN7_ENST00000409667.3_Missense_Mutation_p.I263M|FBLN7_ENST00000409903.1_Intron|FBLN7_ENST00000409450.3_Missense_Mutation_p.I351M	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	397					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GGGATCTGATCCTTGTGCAGA	0.627000													16	124					0	0	1	0	0
FOXN1	8456	broad.mit.edu	37	17	26851533	26851533	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr17:26851533T>G	ENST00000226247.2	+	2	165	c.136T>G	c.(136-138)Ttc>Gtc	p.F46V	FOXN1_ENST00000579795.1_Missense_Mutation_p.F46V	NM_003593.2	NP_003584.2	O15353	FOXN1_HUMAN	forkhead box N1	46					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Lung NSC(42;0.00431)					GCATGCCGGCTTCAGCTGCTC	0.627000													36	150					0	0	1	0	0
DDX17	10521	broad.mit.edu	37	22	38883889	38883889	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:38883889C>T	ENST00000396821.3	-	12	1778	c.1679G>A	c.(1678-1680)gGc>gAc	p.G560D	DDX17_ENST00000444597.1_Missense_Mutation_p.G12D|DDX17_ENST00000381633.3_Missense_Mutation_p.G483D	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	481					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					CTTACCCCCGCCTCCGCCGCC	0.493000													21	80					0	0	1	0	0
KPNA3	3839	broad.mit.edu	37	13	50285092	50285092	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr13:50285092C>G	ENST00000261667.3	-	11	1252	c.838G>C	c.(838-840)Gtt>Ctt	p.V280L		NM_002267.3	NP_002258.2	O00505	IMA3_HUMAN	karyopherin alpha 3 (importin alpha 4)	280					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity			cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(4)	21		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		GAATCAATAACCATCTGTATC	0.363000													4	62					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104067701	104067701	+	Silent	SNP	C	C	T	rs149461913		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:104067701C>T	ENST00000388887.2	+	23	2592	c.2388C>T	c.(2386-2388)caC>caT	p.H796H		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	796					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.H796Q(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGTGCGTTCACGGAACATGCA	0.592000													4	43					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2143934	2143934	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr16:2143934C>A	ENST00000262304.4	-	36	10907	c.10699G>T	c.(10699-10701)Gct>Tct	p.A3567S	RP11-304L19.1_ENST00000570072.1_RNA|PKD1_ENST00000423118.1_Missense_Mutation_p.A3566S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3567					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ACAGCCACAGCCACCAGGAGC	0.687000													6	14					0.217242	0.220485	1	1	0
WDR83	84292	broad.mit.edu	37	19	12780997	12780997	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr19:12780997C>T	ENST00000418543.3	+	5	577	c.228C>T	c.(226-228)tcC>tcT	p.S76S	WDR83OS_ENST00000600694.1_5'UTR|WDR83_ENST00000242796.4_Silent_p.S76S|WDR83OS_ENST00000596731.1_5'UTR	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	76					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						ACTCCAGCTCCTTTGACAACA	0.652000													9	164					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455380	187455380	+	Silent	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr4:187455380C>T	ENST00000307161.5	-	2	717	c.516G>A	c.(514-516)ccG>ccA	p.P172P	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	172					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	AGTAGATCCTCGGGTCGTACT	0.597000													8	140					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21384420	21384420	+	Silent	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:21384420G>C	ENST00000382932.2	-	3	1270	c.1203C>G	c.(1201-1203)gcC>gcG	p.A401A	SLC7A4_ENST00000403586.1_Silent_p.A401A	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	401					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CGAATGTGTAGGCCAGGAGTG	0.657000													9	40					0	0	1	0	0
SH2D4B	387694	broad.mit.edu	37	10	82363419	82363419	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr10:82363419C>G	ENST00000339284.2	+	5	1158	c.728C>G	c.(727-729)gCt>gGt	p.A243G	SH2D4B_ENST00000470604.2_Missense_Mutation_p.A242G|SH2D4B_ENST00000313455.4_Missense_Mutation_p.A194G	NM_207372.2	NP_997255.2	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B	242										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)	13			Colorectal(32;0.229)			TCGCTCCGTGCTATCCAGAAG	0.667000													6	13					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698669	79698669	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:79698669T>G	ENST00000538312.1	+	5	965	c.631T>G	c.(631-633)Ttc>Gtc	p.F211V	FAM46D_ENST00000308293.5_Missense_Mutation_p.F211V	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	211										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						GTATGGAGACTTCCAGGAAGC	0.433000													19	114					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763778	82763778	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chrX:82763778G>C	ENST00000373200.2	+	1	510	c.446G>C	c.(445-447)gGa>gCa	p.G149A	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	149					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						GAACACGGGGGACTCACCCCA	0.672000													3	32					0	0	1	0	0
CDK5	1020	broad.mit.edu	37	7	150754062	150754062	+	Splice_Site	SNP	C	C	T			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr7:150754062C>T	ENST00000485972.1	-	3	808	c.126_splice	c.e3-1	p.G43_splice	CDK5_ENST00000297518.4_Splice_Site_p.G43_splice	NM_004935.3	NP_004926.1	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5	43	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			central_nervous_system(1)|endometrium(2)|lung(5)|urinary_tract(1)	9		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CTCGGCACACCCTGCATATGT	0.647000													18	57					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636666	152636666	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr1:152636666delC	ENST00000368784.1	+	2	140	c.85delC	c.(85-87)ccfs	p.P30fs		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	30	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTAAGTGTCCCCCCAAATG	0.597													7	561	---	---	---	---					
LRP5	4041	broad.mit.edu	37	11	68201243	68201250	+	Frame_Shift_Del	DEL	CTGCGCCT	CTGCGCCT	-	rs151200211		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr11:68201243_68201250delCTGCGCCT	ENST00000294304.7	+	18	4043_4050	c.3937_3944delCTGCGCCT	c.(3937-3945)gfs	p.LRL1313fs		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1313	LDL-receptor class A 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGTGTGGACCTGCGCCTGCGCTGCGAC	0.702													8	166	---	---	---	---					
PUS7L	83448	broad.mit.edu	37	12	44148332	44148335	+	Frame_Shift_Del	DEL	TTTG	TTTG	-	rs150364500		TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr12:44148332_44148335delTTTG	ENST00000416848.2	-	2	1202_1205	c.714_717delCAAA	c.(712-717)aafs	p.NK238fs	PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000344862.5_Frame_Shift_Del_p.NK238fs|PUS7L_ENST00000553166.1_Frame_Shift_Del_p.NK238fs|PUS7L_ENST00000551923.1_Frame_Shift_Del_p.NK238fs	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	238					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTCTGTGGTCTTTGTTTGTATCAG	0.328													8	65	---	---	---	---					
ATP12A	479	broad.mit.edu	37	13	25262564	25262564	+	Frame_Shift_Del	DEL	G	G	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr13:25262564delG	ENST00000218548.6	+	4	669	c.336delG	c.(334-336)gtfs	p.V112fs	ATP12A_ENST00000381946.3_Frame_Shift_Del_p.V112fs	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	112					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.V112V(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGCAGATGGTGGGGGGGTTCT	0.587													8	438	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													7	3	---	---	---	---					
LOC101929735	101929735	broad.mit.edu	37	14	22892202	22892202	+	RNA	DEL	A	A	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr14:22892202delA	ENST00000514473.2	-	0	225				AE000661.37_ENST00000537850.1_RNA|AE000661.37_ENST00000545670.1_RNA|AE000661.37_ENST00000535351.1_RNA|AE000661.37_ENST00000541008.1_RNA																							ctaaaaatacaaaaaaaaaaa	0.547													3	4	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23331163	23331163	+	RNA	DEL	A	A	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr15:23331163delA	ENST00000560464.1	-	0	908																											AATAAATACTAAAAAAAAAAA	0.368													2	4	---	---	---	---					
ADNP2	22850	broad.mit.edu	37	18	77893677	77893677	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr18:77893677delC	ENST00000262198.4	+	4	836	c.381delC	c.(379-381)ttfs	p.F127fs		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	127					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		TCAGAATGTTCCATGCACCTG	0.418													20	74	---	---	---	---					
MIR3648-1	100500862	broad.mit.edu	37	21	9825982	9825983	+	RNA	INS	-	-	C			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr21:9825982_9825983insC	ENST00000581792.1	+	0	151_152					NR_037421.1																						CCCCGTGGCGTCCCCTTCCCCG	0.807													4	7	---	---	---	---					
TXN2	25828	broad.mit.edu	37	22	36876754	36876755	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-62-8394-01A-11D-2323-08	TCGA-62-8394-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fe53cd5-76dc-491e-aa85-bd85386e1fc5	95c5ac14-9da0-40f8-a7d5-dac263b19b66	g.chr22:36876754_36876755delAC	ENST00000216185.2	-	2	596_597	c.130_131delGT	c.(130-132)afs	p.V44fs	TXN2_ENST00000416967.1_5'UTR|TXN2_ENST00000487725.1_5'UTR|TXN2_ENST00000403313.1_Frame_Shift_Del_p.V44fs			Q99757	THIOM_HUMAN	thioredoxin 2	44					cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity			breast(1)|lung(1)|prostate(1)	3						GTTGGGTGTTACAGTCAGGCCA	0.559													11	126	---	---	---	---					
