Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LPAR3	23566	broad.mit.edu	37	1	85279571	85279571	+	Silent	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:85279571A>G	ENST00000440886.1	-	2	1058	c.1020T>C	c.(1018-1020)gaT>gaC	p.D340D	LPAR3_ENST00000370611.3_Silent_p.D340D			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	340					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						GGCTAATACTATCCTCTATGT	0.537000													5	51					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97181826	97181826	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:97181826C>G	ENST00000371247.2	-	8	522	c.333G>C	c.(331-333)gaG>gaC	p.E111D	SORBS1_ENST00000371227.4_Missense_Mutation_p.E111D|SORBS1_ENST00000306402.6_Missense_Mutation_p.E111D|SORBS1_ENST00000371239.1_Missense_Mutation_p.E79D|SORBS1_ENST00000361941.3_Missense_Mutation_p.E111D|SORBS1_ENST00000607232.1_Missense_Mutation_p.E79D|SORBS1_ENST00000347291.4_Missense_Mutation_p.E102D|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000371249.2_Missense_Mutation_p.E79D|SORBS1_ENST00000371246.2_Missense_Mutation_p.E111D|SORBS1_ENST00000353505.5_Missense_Mutation_p.E111D|SORBS1_ENST00000393949.1_Missense_Mutation_p.E102D|SORBS1_ENST00000371245.3_Missense_Mutation_p.E111D|SORBS1_ENST00000354106.3_Missense_Mutation_p.E102D|SORBS1_ENST00000371241.1_Missense_Mutation_p.E70D|SORBS1_ENST00000277982.5_Missense_Mutation_p.E111D			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	111					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AAAGCCTCCACTCATCTGAGA	0.512000													5	37					0	0	1	0	0
TUBB2B	347733	broad.mit.edu	37	6	3224999	3224999	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:3224999C>T	ENST00000259818.7	-	4	1515	c.1324G>A	c.(1324-1326)Gag>Aag	p.E442K	TUBB2B_ENST00000473006.1_5'UTR	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	442					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				GCCTCGTCCTCGCCCTCCTCC	0.652000													45	63					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22866721	22866721	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr15:22866721C>T	ENST00000283645.4	+	17	2463	c.2333C>T	c.(2332-2334)tCt>tTt	p.S778F	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.S778F	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	778					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TTTAGTCTATCTATATCTTTT	0.323000													12	20					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61676955	61676955	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:61676955G>A	ENST00000381103.2	+	20	2335	c.1850G>A	c.(1849-1851)cGg>cAg	p.R617Q	KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Missense_Mutation_p.R637Q|KIF2A_ENST00000506857.1_Missense_Mutation_p.R591Q|KIF2A_ENST00000407818.3_Missense_Mutation_p.R675Q	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	637					blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		GAATCTATTCGGTGGTTAGAA	0.328000													31	33					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75921396	75921396	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:75921396C>G	ENST00000321027.3	-	6	1124	c.991G>C	c.(991-993)Gaa>Caa	p.E331Q	GCFC2_ENST00000541687.1_3'UTR|GCFC2_ENST00000409857.3_Missense_Mutation_p.E293Q	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	331					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										ATTAAATTTTCCACATAAATT	0.294000													7	76					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37586432	37586432	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr21:37586432T>G	ENST00000399151.3	+	8	1043	c.958T>G	c.(958-960)Tat>Gat	p.Y320D		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	320					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTCAAATTCTTATGAAGACCA	0.393000													29	91					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29760111	29760111	+	RNA	SNP	G	G	C	rs114604530	byFrequency	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:29760111G>C	ENST00000457107.1	+	0	83																											GGGAAACGGCGTCTGTGGGGA	0.716000													3	18					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94526191	94526191	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:94526191T>A	ENST00000370225.3	-	14	2148	c.2062A>T	c.(2062-2064)Aat>Tat	p.N688Y	ABCA4_ENST00000535735.1_Missense_Mutation_p.N688Y	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	688					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ACACCCTGATTTTTCAAGGTC	0.478000													18	56					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52257297	52257297	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:52257297G>A	ENST00000494383.1	-	5	1494	c.1495C>T	c.(1495-1497)Cca>Tca	p.P499S	TLR9_ENST00000360658.2_Silent_p.Y345Y|TLR9_ENST00000597542.1_Silent_p.Y369Y			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCCTCTTTTGGTAATTGAAGG	0.547000													33	60					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													6	13					0.00198382	0.00205467	1	1	0
MAST2	23139	broad.mit.edu	37	1	46495140	46495140	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:46495140G>A	ENST00000361297.2	+	19	2504	c.2221G>A	c.(2221-2223)Gag>Aag	p.E741K	MAST2_ENST00000477968.1_3'UTR|MAST2_ENST00000372009.2_Missense_Mutation_p.E671K|MAST2_ENST00000372008.1_Missense_Mutation_p.E626K	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	741	Protein kinase.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GACTTCAGATGAGATTGTGTG	0.547000													12	38					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55183940	55183940	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:55183940C>A	ENST00000337714.3	+	2	1348	c.1115C>A	c.(1114-1116)gCa>gAa	p.A372E	AKAP1_ENST00000571629.1_Missense_Mutation_p.A372E|AKAP1_ENST00000314126.3_Missense_Mutation_p.A372E|AKAP1_ENST00000539273.1_Missense_Mutation_p.A372E|AKAP1_ENST00000572557.1_Missense_Mutation_p.A372E	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	372					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					GGCAAGGTTGCAGGTCGTGTG	0.552000													30	84					2.65835e-16	3.11483e-16	1	1	0
HAO1	54363	broad.mit.edu	37	20	7875803	7875803	+	Missense_Mutation	SNP	G	G	C	rs141975454		TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr20:7875803G>C	ENST00000378789.3	-	5	841	c.790C>G	c.(790-792)Caa>Gaa	p.Q264E		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	264	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CCATCGAGTTGTCGAGCCCCA	0.478000													11	96					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41811594	41811594	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:41811594A>C	ENST00000392006.3	+	14	2449	c.2276A>C	c.(2275-2277)cAg>cCg	p.Q759P	HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.Q659P|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.Q659P|HNRNPUL1_ENST00000602130.1_Intron|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.Q669P|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.Q655P|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.Q670P	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	759	Necessary for interaction with TP53.|Pro-rich.|Tyr-rich.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						AGTTACAGCCAGCCACCCTAC	0.542000													20	84					0	0	1	0	0
MIER3	166968	broad.mit.edu	37	5	56219657	56219657	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:56219657G>C	ENST00000381226.3	-	12	1086	c.1071C>G	c.(1069-1071)gaC>gaG	p.D357E	MIER3_ENST00000381199.3_Missense_Mutation_p.D352E|MIER3_ENST00000381213.3_Missense_Mutation_p.D351E|MIER3_ENST00000409421.1_Missense_Mutation_p.D289E|SETD9_ENST00000541720.1_Intron			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GATCCATATAGTCCCTGAAAA	0.418000													69	156					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2213959	2213959	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:2213959G>A	ENST00000398665.3	+	18	1807	c.1771G>A	c.(1771-1773)Gcg>Acg	p.A591T	DOT1L_ENST00000586024.1_3'UTR|AC004490.1_ENST00000585593.1_RNA	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	591						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACAACCGCGCGCTCCGCGG	0.677000													10	24					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102748608	102748608	+	Nonsense_Mutation	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:102748608C>G	ENST00000370228.1	+	1	826	c.641C>G	c.(640-642)tCa>tGa	p.S214*	C10orf2_ENST00000473656.1_Intron|C10orf2_ENST00000311916.2_Nonsense_Mutation_p.S214*	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	214					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CCTGGGGGCTCAGGATTACGA	0.557000													14	64					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71654450	71654450	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:71654450G>C	ENST00000356340.3	+	10	1159	c.623G>C	c.(622-624)gGa>gCa	p.G208A	COL13A1_ENST00000354547.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398964.3_Missense_Mutation_p.G179A|COL13A1_ENST00000357811.3_Missense_Mutation_p.G208A|COL13A1_ENST00000520267.1_Missense_Mutation_p.G170A|COL13A1_ENST00000398978.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398968.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398973.3_Missense_Mutation_p.G208A|COL13A1_ENST00000517713.1_Missense_Mutation_p.G208A|COL13A1_ENST00000398966.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398972.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398974.3_Missense_Mutation_p.G196A|COL13A1_ENST00000398971.3_Missense_Mutation_p.G208A|COL13A1_ENST00000398969.3_Missense_Mutation_p.G170A|COL13A1_ENST00000520133.1_Missense_Mutation_p.G179A|COL13A1_ENST00000522165.1_Missense_Mutation_p.G208A			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	208	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding	p.G191E(1)|p.G208E(1)		endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	GGACAAAAAGGAGAAAAGGTA	0.463000													5	77					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113688419	113688419	+	Nonsense_Mutation	SNP	G	G	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr11:113688419G>T	ENST00000003302.4	-	13	1492	c.1424C>A	c.(1423-1425)tCa>tAa	p.S475*	USP28_ENST00000537706.1_Nonsense_Mutation_p.S475*|USP28_ENST00000260188.5_Nonsense_Mutation_p.S475*|USP28_ENST00000544967.1_Nonsense_Mutation_p.S183*|USP28_ENST00000545540.1_Nonsense_Mutation_p.S350*	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	475					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GCAGTGCACTGAAGAAAGTGG	0.363000													9	70					7.48243e-07	8.11179e-07	1	1	0
SLC9A7	84679	broad.mit.edu	37	X	46618198	46618198	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:46618198C>G	ENST00000328306.4	-	1	292	c.267G>C	c.(265-267)tgG>tgC	p.W89C		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	89					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GCTTGAAGAGCCAGATGGTGA	0.637000													10	37					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138450767	138450767	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:138450767G>A	ENST00000344876.4	-	1	2862	c.2476C>T	c.(2476-2478)Cct>Tct	p.P826S	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.P826S|PCDH18_ENST00000510305.1_Missense_Mutation_p.P37S|PCDH18_ENST00000507846.1_Missense_Mutation_p.P606S	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	826					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCAACAGCAGGAGTGGCGTGG	0.413000													7	48					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576787	158576787	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:158576787C>A	ENST00000361284.1	+	1	559	c.559C>A	c.(559-561)Cta>Ata	p.L187I		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGTGCTGAGCCTAGCCTGTGG	0.493000													15	129					1.3612e-06	1.46203e-06	1	1	0
TET1	80312	broad.mit.edu	37	10	70405206	70405206	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:70405206A>G	ENST00000373644.4	+	4	2929	c.2720A>G	c.(2719-2721)aAt>aGt	p.N907S		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	907					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CCATCAGAGAATTCCTCCCCA	0.443000													61	118					0	0	1	0	0
RPA4	29935	broad.mit.edu	37	X	96139765	96139765	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:96139765C>T	ENST00000373040.3	+	1	859	c.456C>T	c.(454-456)aaC>aaT	p.N152N	DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000324765.8_Intron|DIAPH2_ENST00000355827.4_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000373061.3_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	152					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						AGGACATGAACGAGTTCACCG	0.458000								Other identified genes with known or suspected DNA repair function					14	113					0	0	1	0	0
PVR	5817	broad.mit.edu	37	19	45162189	45162189	+	Missense_Mutation	SNP	C	C	A	rs35385129	by1000genomes	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:45162189C>A	ENST00000406449.4	+	6	1171	c.1171C>A	c.(1171-1173)Cgt>Agt	p.R391S	PVR_ENST00000403059.4_Intron|PVR_ENST00000425690.3_Intron|CTB-171A8.1_ENST00000590796.1_RNA|PVR_ENST00000344956.4_Intron	NM_001135770.1	NP_001129242.1	P15151	PVR_HUMAN	poliovirus receptor	0					adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		CCagagctgccgtaattgagc	0.532000													6	55					0.00116845	0.00122108	1	1	0
LRRC37A11P	342666	broad.mit.edu	37	17	37186555	37186555	+	RNA	SNP	C	C	T	rs9893920	by1000genomes	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:37186555C>T	ENST00000425901.2	+	0	397					NR_033753.2																						GAACCTTCTCCAGTCCAGCAA	0.587000													4	45					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098959	178098959	+	Missense_Mutation	SNP	T	T	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:178098959T>C	ENST00000397062.3	-	2	640	c.86A>G	c.(85-87)gAt>gGt	p.D29G	NFE2L2_ENST00000464747.1_Missense_Mutation_p.D13G|NFE2L2_ENST00000446151.2_Missense_Mutation_p.D13G|NFE2L2_ENST00000423513.1_Missense_Mutation_p.D13G|NFE2L2_ENST00000397063.4_Missense_Mutation_p.D13G	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	29					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.D29G(6)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TACTCCAAGATCTATATCTTG	0.368000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			10	45					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33832803	33832803	+	Missense_Mutation	SNP	T	T	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:33832803T>C	ENST00000257118.5	-	6	943	c.890A>G	c.(889-891)aAc>aGc	p.N297S	PHC2_ENST00000373416.1_5'UTR|PHC2_ENST00000431992.1_Missense_Mutation_p.N268S|PHC2_ENST00000419414.2_Missense_Mutation_p.N297S	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	297					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CACACTGCTGTTGCCATCTCC	0.607000													37	56					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36766025	36766025	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr13:36766025G>A	ENST00000379881.3	-	5	525	c.437C>T	c.(436-438)aCt>aTt	p.T146I	SOHLH2_ENST00000554962.1_Missense_Mutation_p.T223I|SOHLH2_ENST00000317764.6_Missense_Mutation_p.T146I|CCDC169-SOHLH2_ENST00000511166.1_Missense_Mutation_p.T223I	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		TGCGTTTTCAGTCTTAACTGA	0.433000													21	25					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27765719	27765719	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:27765719T>A	ENST00000451261.2	+	5	1106	c.707T>A	c.(706-708)tTt>tAt	p.F236Y		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						ACTGTACACTTTAACCAGCGT	0.542000													4	8					0	0	1	0	0
CCDC3	83643	broad.mit.edu	37	10	12940464	12940464	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:12940464C>T	ENST00000378839.1	-	7	1342	c.390G>A	c.(388-390)ccG>ccA	p.P130P	CCDC3_ENST00000378825.3_Silent_p.P255P			Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	255						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			CATTGATGTGCGGCAGCGCGC	0.672000													21	39					0	0	1	0	0
SLAIN2	57606	broad.mit.edu	37	4	48422152	48422152	+	Silent	SNP	A	A	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:48422152A>T	ENST00000264313.6	+	7	1789	c.1371A>T	c.(1369-1371)ccA>ccT	p.P457P	SLAIN2_ENST00000512093.1_Silent_p.P290P	NM_020846.1	NP_065897.1	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	457						centrosome				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)	13						TACCTTCTCCAGGCAAATTCC	0.433000													16	45					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131212858	131212858	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:131212858G>C	ENST00000298542.4	-	12	1362	c.1187C>G	c.(1186-1188)tCc>tGc	p.S396C	FRMD7_ENST00000464296.1_Missense_Mutation_p.S381C|FRMD7_ENST00000370879.1_Missense_Mutation_p.S276C	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	396					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTCTGGTTTGGAatgctccag	0.478000													79	195					0	0	1	0	0
MRRF	92399	broad.mit.edu	37	9	125042860	125042860	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr9:125042860A>G	ENST00000344641.3	+	3	634	c.323A>G	c.(322-324)aAt>aGt	p.N108S	MRRF_ENST00000373728.1_Missense_Mutation_p.N108S|MRRF_ENST00000373729.1_Missense_Mutation_p.N64S|MRRF_ENST00000373730.3_Missense_Mutation_p.N108S|MRRF_ENST00000394315.3_Missense_Mutation_p.N108S|MRRF_ENST00000373727.1_Missense_Mutation_p.N108S|MRRF_ENST00000297908.3_Intron|MRRF_ENST00000373723.4_Missense_Mutation_p.N108S|MRRF_ENST00000546115.1_Missense_Mutation_p.N108S	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor	108					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						AAGACTCTCAATATAAGGACC	0.413000													11	70					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331452	55331452	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:55331452G>A	ENST00000391728.4	+	4	673	c.640G>A	c.(640-642)Gac>Aac	p.D214N	KIR3DL1_ENST00000358178.4_Missense_Mutation_p.D119N|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.D214N|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.D214N|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.D214N|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.D214N	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		TGATCCCCTGGACATCGTGGT	0.537000													6	99					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3742495	3742495	+	Nonsense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr18:3742495G>C	ENST00000315677.3	-	6	1785	c.1190C>G	c.(1189-1191)tCa>tGa	p.S397*	DLGAP1_ENST00000400150.3_Nonsense_Mutation_p.S103*|DLGAP1_ENST00000400147.2_Nonsense_Mutation_p.S95*|DLGAP1_ENST00000400149.3_Nonsense_Mutation_p.S105*|DLGAP1_ENST00000400155.1_Nonsense_Mutation_p.S103*|DLGAP1_ENST00000581527.1_Nonsense_Mutation_p.S397*|DLGAP1_ENST00000515196.2_Nonsense_Mutation_p.S397*|DLGAP1_ENST00000400145.2_Nonsense_Mutation_p.S95*|DLGAP1_ENST00000539435.1_Nonsense_Mutation_p.S95*|DLGAP1_ENST00000534970.1_Nonsense_Mutation_p.S109*|DLGAP1_ENST00000581699.1_Nonsense_Mutation_p.S103*|DLGAP1_ENST00000478161.1_5'UTR|DLGAP1_ENST00000584874.1_Nonsense_Mutation_p.S397*	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	397					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GAGTTTGGGTGAGTGTTCATT	0.488000													10	28					0	0	1	0	0
SLC25A34	284723	broad.mit.edu	37	1	16065838	16065838	+	Silent	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:16065838C>G	ENST00000294454.5	+	5	933	c.852C>G	c.(850-852)ctC>ctG	p.L284L		NM_207348.1	NP_997231.1	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	284					transport	integral to membrane|mitochondrial inner membrane				NS(1)|breast(1)|endometrium(3)|large_intestine(1)|lung(2)|skin(1)	9		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACACCATCCTCAGCATGCTCT	0.687000													8	85					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45646959	45646959	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:45646959C>T	ENST00000263736.4	-	17	2186	c.2124G>A	c.(2122-2124)gtG>gtA	p.V708V	SRBD1_ENST00000535761.1_Silent_p.V227V|SRBD1_ENST00000490133.1_5'UTR	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	708					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TGTTAATATCCACTCCCACAA	0.403000													27	94					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													6	14					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233749988	233749988	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:233749988G>A	ENST00000366621.3	+	1	239	c.71G>A	c.(70-72)gGc>gAc	p.G24D		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	24						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TGGTGCTTCGGCTTCCTGGTG	0.687000													3	30					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10680252	10680252	+	Silent	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr18:10680252G>A	ENST00000302079.6	-	47	7367	c.7368C>T	c.(7366-7368)caC>caT	p.H2456H	PIEZO2_ENST00000538948.1_Silent_p.H476H|PIEZO2_ENST00000581680.1_Intron|PIEZO2_ENST00000580640.1_Silent_p.H2544H|PIEZO2_ENST00000503781.3_Silent_p.H2519H|PIEZO2_ENST00000285141.4_Silent_p.H311H			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2519						integral to membrane	ion channel activity										CCAGGAGTTCGTGTATCATTT	0.393000													23	91					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584436	1584436	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:1584436G>A	ENST00000381297.4	-	2	1226	c.1016C>T	c.(1015-1017)gCg>gTg	p.A339V		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	339						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCAGGGTGCGCACCGGCCTC	0.706000			T	CRLF2	"""B-ALL, Downs associated ALL"""								6	72					0	0	1	0	0
NCBP2	22916	broad.mit.edu	37	3	196663952	196663952	+	Splice_Site	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:196663952A>G	ENST00000447325.1	-	4	540	c.189_splice	c.e4-1	p.V64_splice	NCBP2_ENST00000321256.5_Splice_Site_p.V134_splice|NCBP2_ENST00000427641.2_Splice_Site_p.V81_splice|NCBP2_ENST00000452404.2_Splice_Site_p.V116_splice|NCBP2_ENST00000422610.1_Splice_Site_p.V64_splice|NCBP2_ENST00000467803.1_5'UTR			P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	134	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		CTCATCCCGAACCTTTAATGG	0.448000													10	73					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													3	27					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18194273	18194273	+	Silent	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:18194273A>G	ENST00000600835.1	-	3	396	c.93T>C	c.(91-93)ttT>ttC	p.F31F	IL12RB1_ENST00000593993.1_Silent_p.F31F|IL12RB1_ENST00000322153.6_Silent_p.F31F|IL12RB1_ENST00000430026.2_Silent_p.F31F			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	31					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						GCGGGTCCTGAAAACAGCACT	0.567000													12	72					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41548112	41548112	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr8:41548112C>A	ENST00000396942.1	-	32	3947	c.3864G>T	c.(3862-3864)ttG>ttT	p.L1288F	ANK1_ENST00000396945.1_Missense_Mutation_p.L1288F|ANK1_ENST00000379758.2_Missense_Mutation_p.L1288F|ANK1_ENST00000289734.7_Missense_Mutation_p.L1288F|ANK1_ENST00000347528.4_Missense_Mutation_p.L1288F|ANK1_ENST00000352337.4_Missense_Mutation_p.L1288F|ANK1_ENST00000265709.8_Missense_Mutation_p.L1329F			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1288					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACATTCCTTCCAACACCTGCA	0.557000													37	109					7.91308e-09	8.74207e-09	1	1	0
KLHL15	80311	broad.mit.edu	37	X	24006484	24006484	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:24006484G>A	ENST00000328046.8	-	4	1624	c.1369C>T	c.(1369-1371)Cgg>Tgg	p.R457W		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	457										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						CTCCTGGTCCGTTGTTCTATG	0.448000													33	120					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951019	119951019	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:119951019C>T	ENST00000307142.4	+	4	1285	c.1089C>T	c.(1087-1089)agC>agT	p.S363S	SYNPO2_ENST00000434046.2_Silent_p.S363S|SYNPO2_ENST00000429713.2_Silent_p.S363S|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	363						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding	p.S363S(1)		breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGAGTGAAAGCCTGTCAGAAA	0.428000													39	89					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219290443	219290443	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:219290443G>A	ENST00000248444.5	+	4	344	c.256G>A	c.(256-258)Gat>Aat	p.D86N	VIL1_ENST00000392114.2_Intron|VIL1_ENST00000440053.1_Missense_Mutation_p.D86N	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	86	Core.|Necessary for homodimerization.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACACAGATGGATGACTTCCT	0.602000													16	67					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	34046532	34046532	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr22:34046532G>A	ENST00000354992.2	-	4	800	c.229C>T	c.(229-231)Cgc>Tgc	p.R77C	LARGE_ENST00000402320.1_Missense_Mutation_p.R77C|LARGE_ENST00000397394.2_Missense_Mutation_p.R77C|LARGE_ENST00000437602.2_Missense_Mutation_p.R77C|LARGE_ENST00000337431.2_Missense_Mutation_p.R77C|LARGE_ENST00000462606.1_5'UTR	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	77					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				CGGAGGGCGCGGTTCTCCTCC	0.697000													18	64					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79999689	79999689	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:79999689G>A	ENST00000373275.4	-	8	871	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	219								p.R219C(1)		breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GAGTGTCCACGAAGTGTAGCA	0.403000													8	124					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159530506	159530506	+	Nonsense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:159530506C>T	ENST00000389757.3	+	19	3246	c.3121C>T	c.(3121-3123)Cag>Tag	p.Q1041*	AC005042.4_ENST00000342892.4_RNA|PKP4_ENST00000389759.3_Nonsense_Mutation_p.Q1041*	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	1041					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						ACCCATCATTCAGTCAGGTCA	0.463000										HNSCC(62;0.18)			20	122					0	0	1	0	0
IGHV3-11	28450	broad.mit.edu	37	14	106573460	106573460	+	RNA	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr14:106573460C>T	ENST00000390601.2	-	0	243																											CCAGAGGCTGCACAGGAGAGT	0.562000													46	157					0	0	1	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176752076	176752076	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:176752076A>G	ENST00000430069.1	-	13	1419	c.1160T>C	c.(1159-1161)tTg>tCg	p.L387S	TBL1XR1_ENST00000457928.2_Missense_Mutation_p.L387S			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	387					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			ATGTGCTTGCAAATCATGGAC	0.294000													5	28					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477061	128477061	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:128477061C>T	ENST00000322313.4	-	16	2696	c.2538G>A	c.(2536-2538)ctG>ctA	p.L846L		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	846					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGGGAGGTCCCAGCATTGATC	0.637000													4	59					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114899693	114899693	+	Missense_Mutation	SNP	T	T	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:114899693T>C	ENST00000315366.7	-	1	1164	c.298A>G	c.(298-300)Aca>Gca	p.T100A	ARSJ_ENST00000503013.2_5'UTR|ARSJ_ENST00000541197.1_Missense_Mutation_p.T100A	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	100						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		AGAGTAGGTGTTTTAATCTCA	0.473000													31	91					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34558771	34558771	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr10:34558771G>A	ENST00000374789.3	-	22	3567	c.3242C>T	c.(3241-3243)gCt>gTt	p.A1081V	PARD3_ENST00000350537.4_Missense_Mutation_p.A1035V|PARD3_ENST00000346874.4_Missense_Mutation_p.A1044V|PARD3_ENST00000466092.1_5'UTR|PARD3_ENST00000374790.3_Missense_Mutation_p.A1021V|PARD3_ENST00000374794.3_Missense_Mutation_p.A969V|PARD3_ENST00000374788.3_Missense_Mutation_p.A1078V|PARD3_ENST00000545260.1_Missense_Mutation_p.A991V|PARD3_ENST00000545693.1_Missense_Mutation_p.A1065V	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1081					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TTGAATTTCAGCATAGTCACG	0.403000													10	38					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55048266	55048266	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:55048266C>A	ENST00000335056.3	+	5	871	c.833C>A	c.(832-834)gCc>gAc	p.A278D	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GCATTCCAGGCCAACTTTTCT	0.552000													5	80					0.00116845	0.00122108	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48314637	48314637	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr7:48314637G>A	ENST00000435803.1	+	17	5398	c.5374G>A	c.(5374-5376)Gca>Aca	p.A1792T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1792					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGAAGACTTCGCAATTGTGAT	0.388000													5	39					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180886141	180886141	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:180886141G>A	ENST00000367588.4	+	2	957	c.902G>A	c.(901-903)cGc>cAc	p.R301H		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	301										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GAGAGAAACCGCCTGTTGCTG	0.637000													15	74					0	0	1	0	0
SMYD3	64754	broad.mit.edu	37	1	246498678	246498678	+	Silent	SNP	G	G	A	rs148554980		TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:246498678G>A	ENST00000490107.1	-	3	366	c.150C>T	c.(148-150)gtC>gtT	p.V50V	SMYD3_ENST00000388985.4_Silent_p.V109V|SMYD3_ENST00000541742.1_Silent_p.V50V|SMYD3_ENST00000403792.3_Silent_p.V109V	NM_001167740.1	NP_001161212.1	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	109						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			breast(3)|large_intestine(5)|lung(8)|skin(1)	17	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		CAAGTTTGAAGACAACTCTGC	0.413000													5	94					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48750367	48750367	+	Silent	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:48750367C>G	ENST00000285238.8	+	18	2357	c.2277C>G	c.(2275-2277)gtC>gtG	p.V759V		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	759	ABC transporter 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGCAGCGGGTCAGTCTGGCTC	0.597000													7	38					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	100957984	100957984	+	Splice_Site	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:100957984C>A	ENST00000369162.2	-	41	6630		c.e41-1			NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTGGCTTTCCCTGTAAACCAG	0.383000													36	106					6.29468e-14	7.22954e-14	1	1	0
WAS	7454	broad.mit.edu	37	X	48547388	48547388	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:48547388G>A	ENST00000376701.4	+	10	1346	c.1271G>A	c.(1270-1272)gGc>gAc	p.G424D		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	424					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				CCTGCCGGGGGCCTGGCCCCT	0.682000			"""Mis, N, F, S"""			lymphoma							4	12					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93300465	93300465	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:93300465C>T	ENST00000370321.3	+	4	409	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	107					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		GCTGCTGGCCCGCAGGGTATG	0.438000													18	156					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154159595	154159595	+	Silent	SNP	A	A	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:154159595A>G	ENST00000360256.4	-	14	2670	c.2470T>C	c.(2470-2472)Tta>Cta	p.L824L		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	824	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AGATCAGATAAGGATAGCCCA	0.418000													66	132					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21483062	21483062	+	Silent	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr18:21483062G>A	ENST00000313654.9	+	49	6532	c.6291G>A	c.(6289-6291)gcG>gcA	p.A2097A	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Silent_p.A432A|LAMA3_ENST00000269217.6_Silent_p.A488A|LAMA3_ENST00000399516.3_Silent_p.A2041A	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2097	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAACATTGCGCTGCAGCTGA	0.363000													26	74					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72700743	72700743	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:72700743G>C	ENST00000469092.1	-	3	541	c.265C>G	c.(265-267)Cag>Gag	p.Q89E	CD300LF_ENST00000343125.4_Missense_Mutation_p.Q89E|CD300LF_ENST00000583937.1_Missense_Mutation_p.Q86E|CD300LF_ENST00000464910.1_Missense_Mutation_p.Q89E|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000326165.6_Missense_Mutation_p.Q86E|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000301573.9_Missense_Mutation_p.Q86E|CD300LF_ENST00000361254.4_Missense_Mutation_p.Q89E|CD300LF_ENST00000581500.1_Missense_Mutation_p.Q89E			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	86	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CGGTTTTTCTGATTGTCCTTG	0.493000													14	224					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1415317	1415317	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:1415317G>A	ENST00000446702.2	+	15	2443	c.1816G>A	c.(1816-1818)Gtg>Atg	p.V606M	CNTN6_ENST00000350110.2_Missense_Mutation_p.V606M|CNTN6_ENST00000539053.1_Missense_Mutation_p.V534M			Q9UQ52	CNTN6_HUMAN	contactin 6	606	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GGATGTGCAAGTGGAAGACAT	0.393000													25	55					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88047769	88047769	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:88047769C>T	ENST00000504921.2	-	5	1166	c.494G>A	c.(493-495)gGa>gAa	p.G165E	MEF2C_ENST00000539796.1_Missense_Mutation_p.G117E|MEF2C_ENST00000508569.1_Missense_Mutation_p.G165E|MEF2C_ENST00000340208.5_Missense_Mutation_p.G183E|MEF2C_ENST00000510942.1_Missense_Mutation_p.G165E|MEF2C_ENST00000437473.2_Missense_Mutation_p.G165E|MEF2C_ENST00000503554.1_5'UTR|MEF2C_ENST00000506554.1_Missense_Mutation_p.G165E|MEF2C_ENST00000514015.1_Missense_Mutation_p.G165E|MEF2C_ENST00000424173.2_Missense_Mutation_p.G163E|MEF2C_ENST00000514028.1_Missense_Mutation_p.G165E			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	165	Ser-rich.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GTTGGGGTTTCCCAGTGAGCT	0.532000										HNSCC(66;0.2)			8	98					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10392085	10392085	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:10392085C>T	ENST00000397077.1	-	14	2753	c.2178G>A	c.(2176-2178)ggG>ggA	p.G726G	ATP2B2_ENST00000383800.4_Silent_p.G726G|ATP2B2_ENST00000360273.2_Silent_p.G771G|ATP2B2_ENST00000352432.4_Silent_p.G771G|ATP2B2_ENST00000343816.4_Silent_p.G757G			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	771					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CACGCACCTCCCCCTTCTCGT	0.592000													17	36					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55183939	55183939	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:55183939G>T	ENST00000337714.3	+	2	1347	c.1114G>T	c.(1114-1116)Gca>Tca	p.A372S	AKAP1_ENST00000571629.1_Missense_Mutation_p.A372S|AKAP1_ENST00000314126.3_Missense_Mutation_p.A372S|AKAP1_ENST00000539273.1_Missense_Mutation_p.A372S|AKAP1_ENST00000572557.1_Missense_Mutation_p.A372S	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	372					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TGGCAAGGTTGCAGGTCGTGT	0.557000													30	84					3.73148e-12	4.20244e-12	1	1	0
RAP1GAP	5909	broad.mit.edu	37	1	21926031	21926031	+	Missense_Mutation	SNP	C	C	T	rs138045307	byFrequency	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:21926031C>T	ENST00000542643.2	-	23	2112	c.1810G>A	c.(1810-1812)Gtg>Atg	p.V604M	RAP1GAP_ENST00000374765.4_Missense_Mutation_p.V578M|RAP1GAP_ENST00000374763.2_Missense_Mutation_p.V663M|RAP1GAP_ENST00000290101.4_Missense_Mutation_p.V642M|RAP1GAP_ENST00000374761.2_Missense_Mutation_p.V609M	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	578					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TCCTCCACCACGCTGGCGAAG	0.667000													25	49					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24446044	24446044	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:24446044T>G	ENST00000230036.1	-	19	1946	c.1836A>C	c.(1834-1836)ttA>ttC	p.L612F		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	612						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CTCGGATGTGTAACAAATGGC	0.512000													7	94					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	60					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41550204	41550204	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr8:41550204C>T	ENST00000396942.1	-	31	3903	c.3820G>A	c.(3820-3822)Gag>Aag	p.E1274K	ANK1_ENST00000396945.1_Missense_Mutation_p.E1274K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1274K|ANK1_ENST00000289734.7_Missense_Mutation_p.E1274K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1274K|ANK1_ENST00000352337.4_Missense_Mutation_p.E1274K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1315K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1274					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGAAGTTCTCATGCTGCTCC	0.572000													182	490					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	60					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138163365	138163365	+	Silent	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:138163365C>T	ENST00000302763.7	+	7	1110	c.1020C>T	c.(1018-1020)gtC>gtT	p.V340V	CTNNA1_ENST00000518825.1_Silent_p.V340V|CTNNA1_ENST00000355078.5_Silent_p.V237V	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	340	Interaction with alpha-actinin.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTAATGCTGTCCGCCAGGCCC	0.502000													7	36					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5443840	5443840	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr18:5443840G>A	ENST00000341928.2	-	5	866	c.526C>T	c.(526-528)Cga>Tga	p.R176*	EPB41L3_ENST00000540638.2_Nonsense_Mutation_p.R176*|EPB41L3_ENST00000400111.3_Nonsense_Mutation_p.R176*|EPB41L3_ENST00000342933.3_Nonsense_Mutation_p.R176*|EPB41L3_ENST00000544123.1_Nonsense_Mutation_p.R176*|EPB41L3_ENST00000542652.2_Intron	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	176	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						AACTTACTTCGAACCTGTTTT	0.343000													8	61					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461394	76461394	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr16:76461394C>A	ENST00000307431.8	+	5	818	c.433C>A	c.(433-435)Ctc>Atc	p.L145I	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.L145I|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.L121I|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.L149I|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	146	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GTACTATAGACTCCAGCCTTC	0.433000													8	172					0.0381472	0.0381472	1	1	0
TLR10	81793	broad.mit.edu	37	4	38775656	38775656	+	Missense_Mutation	SNP	G	G	A	rs149319935		TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:38775656G>A	ENST00000308973.4	-	4	2161	c.1556C>T	c.(1555-1557)gCg>gTg	p.A519V	TLR10_ENST00000508334.1_Missense_Mutation_p.A519V|TLR10_ENST00000506111.1_Missense_Mutation_p.A519V|TLR10_ENST00000361424.2_Missense_Mutation_p.A519V	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	519					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ATTTCTTCCCGCATTTAGAGT	0.388000													23	135					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44216503	44216503	+	Missense_Mutation	SNP	A	A	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:44216503A>C	ENST00000371554.1	+	2	351	c.137A>C	c.(136-138)aAt>aCt	p.N46T	HSP90AB1_ENST00000353801.3_Missense_Mutation_p.N46T|HSP90AB1_ENST00000371646.5_Missense_Mutation_p.N46T			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	46					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTGATCTCTAATGCTTCTGAT	0.438000													18	196					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr16:90161926T>C	ENST00000564451.1	+	0	1279				TUBB8P7_ENST00000567960.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													6	38					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737344	248737344	+	Missense_Mutation	SNP	G	G	A	rs148907652	byFrequency	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr1:248737344G>A	ENST00000328782.2	-	1	736	c.715C>T	c.(715-717)Cgc>Tgc	p.R239C		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTTCCTGCGGCCGGCGGCA	0.567000													13	211					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119466053	119466053	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr3:119466053C>A	ENST00000273390.5	+	15	2071	c.1994C>A	c.(1993-1995)gCa>gAa	p.A665E	RP11-169N13.4_ENST00000489428.2_RNA	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CAAGCCAGGGCAGAAATAGAG	0.403000													34	56					9.65021e-13	1.09747e-12	1	1	0
TEP1	7011	broad.mit.edu	37	14	20850171	20850171	+	Missense_Mutation	SNP	G	G	A	rs147151688	byFrequency	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr14:20850171G>A	ENST00000262715.5	-	30	4365	c.4325C>T	c.(4324-4326)cCg>cTg	p.P1442L	TEP1_ENST00000556935.1_Missense_Mutation_p.P1334L|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1442	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGTCCCCTTCGGTAGTGTCCG	0.592000													5	45					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39867145	39867145	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr19:39867145G>A	ENST00000314471.6	+	8	2011	c.976G>A	c.(976-978)Gag>Aag	p.E326K	SAMD4B_ENST00000596368.1_Intron|SAMD4B_ENST00000598913.1_Missense_Mutation_p.E326K	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	326	SAM.						protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GATGAGCTACGAGGAGATGAT	0.562000													4	51					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176793799	176793799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:176793799C>T	ENST00000408923.3	+	4	525	c.337C>T	c.(337-339)Cag>Tag	p.Q113*		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	113	RGS.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGATACCCAGCAGGTGGGGGA	0.647000													6	66					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27817349	27817349	+	Missense_Mutation	SNP	G	G	C			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr12:27817349G>C	ENST00000318304.8	+	12	1304	c.1021G>C	c.(1021-1023)Gac>Cac	p.D341H	PPFIBP1_ENST00000228425.6_Missense_Mutation_p.D321H|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.D310H|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.D188H	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	341					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GAAAATGCAAGACACGGTGGT	0.368000													4	27					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33993256	33993256	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr15:33993256G>T	ENST00000389232.4	+	42	6528	c.6458G>T	c.(6457-6459)aGc>aTc	p.S2153I	RYR3_ENST00000415757.3_Missense_Mutation_p.S2153I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2153	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTAGCGCTGAGCTTAGAGGAA	0.567000											OREG0023030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					0.014758	0.0148863	1	1	0
DST	667	broad.mit.edu	37	6	56473731	56473731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr6:56473731G>A	ENST00000370754.5	-	39	5595	c.5596C>T	c.(5596-5598)Cag>Tag	p.Q1866*	DST_ENST00000370788.2_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000312431.6_Nonsense_Mutation_p.Q1688*|DST_ENST00000361203.3_Nonsense_Mutation_p.Q1688*|DST_ENST00000244364.6_Intron|DST_ENST00000370769.4_Nonsense_Mutation_p.Q1688*|DST_ENST00000446842.2_Nonsense_Mutation_p.Q1362*			Q03001	DYST_HUMAN	dystonin	1688					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACCAAGTTCTGTTGGAAAGCC	0.418000													12	160					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	784289	784289	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr16:784289G>A	ENST00000301694.5	-	5	511	c.500C>T	c.(499-501)cCg>cTg	p.P167L	NARFL_ENST00000251588.2_Silent_p.T211T|NARFL_ENST00000540986.1_Silent_p.T109T|NARFL_ENST00000568545.1_Silent_p.T109T|HAGHL_ENST00000569604.1_3'UTR			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	0					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GGGACCGGGCGGTGCTGATGT	0.682000													10	45					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17881630	17881630	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:17881630C>G	ENST00000448223.2	-	21	2508	c.2239G>C	c.(2239-2241)Gaa>Caa	p.E747Q	SMC6_ENST00000381272.4_Missense_Mutation_p.E773Q|SMC6_ENST00000351948.4_Missense_Mutation_p.E747Q|SMC6_ENST00000402989.1_Missense_Mutation_p.E747Q	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	747					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTTTATTTTCCTGAGCTTCA	0.269000													3	26					0	0	1	0	0
LOC101927533	101927533	broad.mit.edu	37	2	65738863	65738863	+	RNA	DEL	G	G	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:65738863delG	ENST00000377977.3	+	0	862																											TTTTTTTTTTGTCCAGGAGGC	0.303													4	6	---	---	---	---					
FMNL2	114793	broad.mit.edu	37	2	153504313	153504314	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:153504313_153504314delTT	ENST00000288670.9	+	26	3540_3541	c.3173_3174delTT	c.(3172-3174)cfs	p.L1058fs	FMNL2_ENST00000475377.2_3'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	1058	DAD.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TTTACAGATCTTAGAAACCAAC	0.485													41	202	---	---	---	---					
LRP2	4036	broad.mit.edu	37	2	170042394	170042396	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr2:170042394_170042396delTCA	ENST00000263816.3	-	50	9747_9749	c.9462_9464delTGA	c.(9460-9465)gaa>ga	p.DE3154del		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3154	EGF-like 12; calcium-binding (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTCTGTGCATTCATCAATATCAA	0.473													15	159	---	---	---	---					
ZNF827	152485	broad.mit.edu	37	4	146823705	146823708	+	Frame_Shift_Del	DEL	GCAT	GCAT	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr4:146823705_146823708delGCAT	ENST00000508784.1	-	2	930_933	c.703_706delATGC	c.(703-708)gafs	p.MR235fs	ZNF827_ENST00000379448.4_Frame_Shift_Del_p.MR235fs|ZNF827_ENST00000513320.1_Intron			Q17R98	ZN827_HUMAN	zinc finger protein 827	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					GACTCAAATCGCATGGTCTCCTCA	0.515													19	69	---	---	---	---					
APC	324	broad.mit.edu	37	5	112174472	112174475	+	Frame_Shift_Del	DEL	AAAC	AAAC	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr5:112174472_112174475delAAAC	ENST00000457016.1	+	16	3561_3564	c.3181_3184delAAAC	c.(3181-3186)aafs	p.KQ1061fs	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Frame_Shift_Del_p.KQ1061fs|APC_ENST00000508376.2_Frame_Shift_Del_p.KQ1061fs			P25054	APC_HUMAN	adenomatous polyposis coli	1061	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.Q1062fs*1(3)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGATGAAATAAAACAAAGTGAGCA	0.368		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			9	33	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													4	4	---	---	---	---					
DYNC1H1	1778	broad.mit.edu	37	14	102476332	102476332	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr14:102476332delC	ENST00000360184.4	+	30	6294	c.6130delC	c.(6130-6132)ccfs	p.P2044fs		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2044	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CATGACCAAGCCCGACCGGCA	0.537													28	68	---	---	---	---					
DISP2	85455	broad.mit.edu	37	15	40660584	40660584	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr15:40660584delC	ENST00000267889.3	+	8	2358	c.2271delC	c.(2269-2271)ttfs	p.F757fs		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	757					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GCCAGCTGTTCCTGTTCGAGC	0.721													11	56	---	---	---	---					
UPF3AP2	147150	broad.mit.edu	37	17	20279654	20279655	+	RNA	INS	-	-	T			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr17:20279654_20279655insT	ENST00000578315.1	-	0	51_52																											atctgtctctcttttttttttt	0.381													4	6	---	---	---	---					
BCRP7	100133163	broad.mit.edu	37	22	18843723	18843724	+	RNA	INS	-	-	A			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chr22:18843723_18843724insA	ENST00000412938.1	+	0	2337																											AGGGGCACCCCACGGCCTGGAG	0.619													3	5	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578866	154578866	+	RNA	DEL	T	T	-			TCGA-62-8395-01A-11D-2323-08	TCGA-62-8395-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca997f5d-0e39-40d9-8aae-c06dab64b7c8	dac8a0b8-e83f-4296-b141-63f45f4291f2	g.chrX:154578866delT	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTCTCTCTGTTTTTTTTTTT	0.418													9	33	---	---	---	---					
