Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GDF6	392255	broad.mit.edu	37	8	97172696	97172696	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:97172696G>T	ENST00000287020.5	-	1	324	c.225C>A	c.(223-225)ccC>ccA	p.P75P		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	75					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					GCTGAGCCCGGGGTTCGTCCT	0.701000													22	56					1.10513e-12	1.62721e-12	0.624587	1	0
LRP1B	53353	broad.mit.edu	37	2	140992411	140992411	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:140992411G>T	ENST00000389484.3	-	90	14574	c.13603C>A	c.(13603-13605)Cac>Aac	p.H4535N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4535					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ggcgctgtgtgtggaagcttg	0.413000										TSP Lung(27;0.18)			17	40					2.39556e-15	3.78635e-15	0.639603	1	0
SMARCA4	6597	broad.mit.edu	37	19	11129651	11129651	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:11129651G>A	ENST00000358026.2	+	17	2741	c.2457G>A	c.(2455-2457)gcG>gcA	p.A819A	SMARCA4_ENST00000429416.3_Silent_p.A819A|SMARCA4_ENST00000450717.3_Silent_p.A819A|SMARCA4_ENST00000413806.3_Silent_p.A819A|SMARCA4_ENST00000541122.2_Silent_p.A819A|SMARCA4_ENST00000444061.3_Silent_p.A819A|SMARCA4_ENST00000344626.4_Silent_p.A819A|SMARCA4_ENST00000589677.1_Silent_p.A819A|SMARCA4_ENST00000590574.1_Silent_p.A819A	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	819	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCAACTGGGCGTACGAGTTTG	0.552000			"""F, N, Mis"""		NSCLC								4	151					0	0	0.184627	0	0
KLHL13	90293	broad.mit.edu	37	X	117079468	117079468	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:117079468G>T	ENST00000371876.1	-	1	2437	c.16C>A	c.(16-18)Cat>Aat	p.H6N	KLHL13_ENST00000539496.1_Missense_Mutation_p.H60N|KLHL13_ENST00000262820.3_Missense_Mutation_p.H57N|KLHL13_ENST00000541812.1_Missense_Mutation_p.H41N|KLHL13_ENST00000540167.1_Missense_Mutation_p.H41N|KLHL13_ENST00000371878.1_Missense_Mutation_p.H6N|KLHL13_ENST00000469946.1_Missense_Mutation_p.H6N|KLHL13_ENST00000371882.1_Missense_Mutation_p.H6N|KLHL13_ENST00000545703.1_Missense_Mutation_p.H15N			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	57					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GACTGCAAATGGGATGAGAGG	0.448000													17	102					4.4004e-07	5.47587e-07	0.654019	1	0
PLA2G4C	8605	broad.mit.edu	37	19	48558226	48558226	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:48558226C>A	ENST00000354276.3	-	15	1665	c.1338G>T	c.(1336-1338)tgG>tgT	p.W446C	PLA2G4C_ENST00000596510.1_5'UTR|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.W446C|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.W456C|PLA2G4C_ENST00000599921.1_Missense_Mutation_p.W446C	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	446	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		GGGCCTTGGACCACAAATCCA	0.547000													32	117					6.50621e-10	8.89271e-10	0.769981	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137064	40137064	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:40137064C>T	ENST00000278198.2	-	2	2742	c.779G>A	c.(778-780)cGg>cAg	p.R260Q	LRRC4C_ENST00000527150.1_Missense_Mutation_p.R260Q|LRRC4C_ENST00000528697.1_Missense_Mutation_p.R260Q|LRRC4C_ENST00000530763.1_Missense_Mutation_p.R260Q			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	260					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAAGGCATTCCGTTCAATCAC	0.448000													63	158					0	0	0.870114	0	0
MS4A3	932	broad.mit.edu	37	11	59828739	59828739	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:59828739C>A	ENST00000278865.3	+	2	179	c.106C>A	c.(106-108)Ccc>Acc	p.P36T	MS4A3_ENST00000358152.2_Missense_Mutation_p.P36T|MS4A3_ENST00000526199.1_3'UTR|MS4A3_ENST00000534744.1_Missense_Mutation_p.P36T|MS4A3_ENST00000395032.2_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	36						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				TGTCTACCAGCCCATAGATGG	0.458000													35	94					9.62906e-15	1.49711e-14	0.819951	1	0
DST	667	broad.mit.edu	37	6	56346870	56346870	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:56346870C>A	ENST00000370754.5	-	90	21415	c.21416G>T	c.(21415-21417)cGg>cTg	p.R7139L	DST_ENST00000361203.3_Missense_Mutation_p.R6850L|DST_ENST00000370769.4_Missense_Mutation_p.R6961L|DST_ENST00000446842.2_Missense_Mutation_p.R6635L|DST_ENST00000421834.2_Missense_Mutation_p.R4873L|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.R4547L|DST_ENST00000370788.2_Missense_Mutation_p.R4764L			Q03001	DYST_HUMAN	dystonin	6959					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATGAGAGTCCGGAGAGCATC	0.448000													4	19					0.150653	0.15318	0.150653	1	0
RP1L1	94137	broad.mit.edu	37	8	10465391	10465391	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:10465391C>T	ENST00000382483.3	-	4	6440	c.6217G>A	c.(6217-6219)Gag>Aag	p.E2073K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2073					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTTCTGCCTCCTGGACCTCC	0.632000													55	128					0	0	0.870114	0	0
PTGDR	5729	broad.mit.edu	37	14	52734790	52734790	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:52734790C>T	ENST00000306051.2	+	1	360	c.258C>T	c.(256-258)gcC>gcT	p.A86A	PTGDR_ENST00000553372.1_Silent_p.A86A	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	86						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding	p.A86A(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	TGCTGGCTGCCTACGCTCAGA	0.622000													17	50					0	0	0.557998	0	0
WNT16	51384	broad.mit.edu	37	7	120965499	120965499	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:120965499C>A	ENST00000361301.2	+	1	79	c.30C>A	c.(28-30)acC>acA	p.T10T		NM_016087.2	NP_057171.2	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	0					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					TCAGGGAGACCCTCTTCACAG	0.478000													16	128					1.87028e-06	2.28895e-06	0.608945	1	0
RP1L1	94137	broad.mit.edu	37	8	10464760	10464760	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:10464760G>T	ENST00000382483.3	-	4	7071	c.6848C>A	c.(6847-6849)cCa>cAa	p.P2283Q		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2283					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GTCTCCACCTGGGGAAGGGGG	0.597000													74	135					2.05912e-35	3.8151e-35	0.870114	1	0
DDX60	55601	broad.mit.edu	37	4	169215041	169215041	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:169215041C>A	ENST00000393743.3	-	7	1070	c.779G>T	c.(778-780)cGg>cTg	p.R260L		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	260							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AAAGACACGCCGAATGTCAGA	0.403000													24	70					9.57634e-11	1.34189e-10	0.654019	1	0
RYR2	6262	broad.mit.edu	37	1	237666652	237666652	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:237666652T>A	ENST00000366574.2	+	22	2777	c.2460T>A	c.(2458-2460)gcT>gcA	p.A820A	RYR2_ENST00000360064.6_Silent_p.A818A|RYR2_ENST00000542537.1_Silent_p.A804A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	820					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGGGTATGCTCCTTGTTATG	0.463000													5	30					0	0	0.184627	0	0
SDK2	54549	broad.mit.edu	37	17	71334835	71334835	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:71334835G>T	ENST00000392650.3	-	45	6410	c.6410C>A	c.(6409-6411)cCc>cAc	p.P2137H	SDK2_ENST00000388726.3_Missense_Mutation_p.P2118H|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2137					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGGGTTCTGGGGCGTTGGAGT	0.657000													5	34					0.00307968	0.00329718	0.278610	1	0
STAM	8027	broad.mit.edu	37	10	17747010	17747010	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:17747010G>A	ENST00000377524.3	+	11	1257	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	STAM_ENST00000540523.1_Missense_Mutation_p.E237K	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	348					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						TGAAAAGCTGGAAGATATTGA	0.358000													14	59					0	0	0.520397	0	0
CYBB	1536	broad.mit.edu	37	X	37670135	37670135	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37670135G>T	ENST00000378588.4	+	13	1745	c.1678G>T	c.(1678-1680)Gga>Tga	p.G560*	CYBB_ENST00000536160.1_Nonsense_Mutation_p.G293*|TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000545017.1_Nonsense_Mutation_p.G528*	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	560					electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						TGGCCCTCGGGGAGTGCATTT	0.433000													12	33					0.457914	0.46207	0.457914	1	0
SEMA3E	9723	broad.mit.edu	37	7	83032006	83032006	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:83032006C>A	ENST00000307792.3	-	10	1552	c.1085G>T	c.(1084-1086)gGa>gTa	p.G362V	SEMA3E_ENST00000427262.1_Missense_Mutation_p.G302V	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	362	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GTATTCAGGTCCTTCCTTATG	0.368000													20	35					1.33986e-20	2.28565e-20	0.681144	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64601678	64601678	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:64601678C>A	ENST00000498707.1	-	20	3324	c.2982G>T	c.(2980-2982)ggG>ggT	p.G994G	ADAMTS9_ENST00000295903.4_Silent_p.G966G	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	994	TSP type-1 3.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGTTACATTCCCCTGAGCATT	0.488000													54	197					1.44317e-28	2.59459e-28	0.870114	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656903	40656903	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:40656903C>T	ENST00000406785.1	-	2	707	c.518G>A	c.(517-519)gGa>gAa	p.G173E	SLC8A1_ENST00000408028.2_Missense_Mutation_p.G173E|SLC8A1_ENST00000406391.2_Missense_Mutation_p.G173E|SLC8A1_ENST00000403092.1_Missense_Mutation_p.G173E|SLC8A1_ENST00000405901.3_Missense_Mutation_p.G173E|SLC8A1_ENST00000402441.1_Missense_Mutation_p.G173E|SLC8A1_ENST00000332839.4_Missense_Mutation_p.G173E|SLC8A1_ENST00000405269.1_Missense_Mutation_p.G173E|SLC8A1_ENST00000542756.1_Missense_Mutation_p.G173E|SLC8A1_ENST00000542024.1_Missense_Mutation_p.G173E			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	173					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.G173V(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGCAGCACTTCCCACGATGGT	0.468000													4	31					0	0	0.150653	0	0
IGLV2-11	28816	broad.mit.edu	37	22	23135302	23135302	+	RNA	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:23135302C>T	ENST00000390314.2	+	0	206																											AACTATGTCTCCTGGTACCAA	0.552000													36	381					0	0	0.870114	0	0
GRM7	2917	broad.mit.edu	37	3	7340476	7340476	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:7340476G>T	ENST00000486284.1	+	3	1116	c.842G>T	c.(841-843)aGg>aTg	p.R281M	GRM7_ENST00000357716.4_Missense_Mutation_p.R281M|GRM7_ENST00000389336.4_Missense_Mutation_p.R281M|GRM7_ENST00000402647.2_Missense_Mutation_p.R281M|GRM7_ENST00000403881.1_Missense_Mutation_p.R281M	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	281					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCCAACTCCAGGGCCGTCGTG	0.443000													13	46					2.61681e-11	3.71365e-11	0.457914	1	0
ARHGAP33	115703	broad.mit.edu	37	19	36275140	36275140	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:36275140G>T	ENST00000007510.4	+	16	1632	c.1488G>T	c.(1486-1488)tcG>tcT	p.S496S	ARHGAP33_ENST00000314737.5_Silent_p.S496S|ARHGAP33_ENST00000378944.5_Silent_p.S360S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	496	Rho-GAP.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GGGTGCAGTCGGTGGTGGTGG	0.672000													34	133					7.66079e-34	1.41153e-33	0.853193	1	0
GRM7	2917	broad.mit.edu	37	3	7348300	7348300	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:7348300G>C	ENST00000486284.1	+	4	1268	c.994G>C	c.(994-996)Ggg>Cgg	p.G332R	GRM7_ENST00000357716.4_Missense_Mutation_p.G332R|GRM7_ENST00000389336.4_Missense_Mutation_p.G332R|GRM7_ENST00000402647.2_Missense_Mutation_p.G332R|GRM7_ENST00000403881.1_Missense_Mutation_p.G332R	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	332					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TATCGCAGAAGGGGCCATCAC	0.517000													14	71					0	0	0.520397	0	0
UNC5C	8633	broad.mit.edu	37	4	96137341	96137341	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:96137341G>A	ENST00000453304.1	-	10	2015	c.1667C>T	c.(1666-1668)gCt>gTt	p.A556V	UNC5C_ENST00000506749.1_Missense_Mutation_p.A575V	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	556	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AATGGCCCCAGCGGGAATCAG	0.448000													4	28					0	0	0.184627	0	0
ZNF317	57693	broad.mit.edu	37	19	9271755	9271755	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:9271755C>T	ENST00000247956.6	+	7	1739	c.1434C>T	c.(1432-1434)gcC>gcT	p.A478A	ZNF317_ENST00000360385.3_Silent_p.A446A	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						AATGCGCCGCCTGCGGGAAAG	0.547000													9	42					0	0	0.335167	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488869	20488869	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:20488869C>A	ENST00000555186.1	+	0	352					NR_038836.1																						TGGGTATAACCGTGCTGTGGA	0.438000													10	81					2.27111e-07	2.869e-07	0.411799	1	0
BRINP1	1620	broad.mit.edu	37	9	121929695	121929695	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:121929695C>G	ENST00000265922.3	-	8	2414	c.1953G>C	c.(1951-1953)aaG>aaC	p.K651N	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		651					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CGTCTGAGATCTTGATGTAGA	0.592000													24	156					0	0	0.667858	0	0
EPHA5	2044	broad.mit.edu	37	4	66270111	66270111	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:66270111C>A	ENST00000273854.3	-	8	2371	c.1771G>T	c.(1771-1773)Ggc>Tgc	p.G591C	EPHA5_ENST00000511294.1_Missense_Mutation_p.G592C|EPHA5_ENST00000354839.4_Missense_Mutation_p.G591C|EPHA5_ENST00000432638.2_Missense_Mutation_p.G428C	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	591					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						AGGAGGACGCCGATAACCACT	0.488000										TSP Lung(17;0.13)			11	37					0.00136819	0.00147668	0.411799	1	0
SORCS1	114815	broad.mit.edu	37	10	108337309	108337309	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:108337309C>T	ENST00000263054.6	-	26	3383	c.3376G>A	c.(3376-3378)Gta>Ata	p.V1126I	SORCS1_ENST00000369698.1_Silent_p.E714E|SORCS1_ENST00000344440.6_Intron	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1126						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGTAAAGCTACTCTCCTAAGA	0.493000													7	53					0	0	0.248553	0	0
TRBV7-8	28590	broad.mit.edu	37	7	142099565	142099565	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:142099565C>A	ENST00000390359.3	-	0	275																											GATCACTGGGCAGCCCCGATT	0.547000													16	29					2.23348e-06	2.68421e-06	0.500413	1	0
TXNL1	9352	broad.mit.edu	37	18	54305660	54305660	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:54305660C>T	ENST00000217515.6	-	1	216	c.12G>A	c.(10-12)gtG>gtA	p.V4V	TXNL1_ENST00000590954.1_Silent_p.V4V|TXNL1_ENST00000540155.1_5'UTR	NM_004786.2	NP_004777.1	O43396	TXNL1_HUMAN	thioredoxin-like 1	4	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		CGACGGGCTTCACCCCCACCA	0.642000													9	15					0	0	0.387290	0	0
CASK	8573	broad.mit.edu	37	X	41419065	41419065	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:41419065C>A	ENST00000318588.9	-	18	1749	c.1704G>T	c.(1702-1704)gtG>gtT	p.V568V	CASK_ENST00000442742.2_Silent_p.V568V|CASK_ENST00000361962.4_Silent_p.V568V|CASK_ENST00000378158.1_Silent_p.V568V|CASK_ENST00000378154.1_Silent_p.V568V|CASK_ENST00000472704.1_5'UTR|CASK_ENST00000421587.2_Silent_p.V562V|CASK_ENST00000378163.1_Silent_p.V568V|CASK_ENST00000378166.4_Silent_p.V568V			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	568					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						GGTAACTTGGCACAATCTTGA	0.458000													5	51					3.09899e-07	3.88538e-07	0.307466	1	0
PTENP1	11191	broad.mit.edu	37	9	33676258	33676258	+	RNA	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:33676258G>T	ENST00000532280.1	-	0	1239					NR_023917.1																						CATTATACCAGTTCGTCCCTT	0.388000													25	84					3.73148e-12	5.41064e-12	0.717897	1	0
SHROOM2	357	broad.mit.edu	37	X	9864701	9864701	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:9864701G>T	ENST00000380913.3	+	4	2843	c.2753G>T	c.(2752-2754)aGg>aTg	p.R918M		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	918					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				GTTCATGGGAGGTCCCGGTCT	0.597000													3	21					0.150653	0.15318	0.150653	1	0
ROBO1	6091	broad.mit.edu	37	3	78988072	78988072	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:78988072G>A	ENST00000436010.2	-	2	1058	c.61C>T	c.(61-63)Cgt>Tgt	p.R21C	ROBO1_ENST00000464233.1_Missense_Mutation_p.R60C|ROBO1_ENST00000467549.1_Missense_Mutation_p.R21C|ROBO1_ENST00000495273.1_Missense_Mutation_p.R21C			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	60					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGACGAAGACGGGAGCCTGCA	0.393000													11	49					0	0	0.387290	0	0
LRRC7	57554	broad.mit.edu	37	1	70505424	70505424	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:70505424C>A	ENST00000310961.5	+	22	4236	c.3818C>A	c.(3817-3819)gCa>gAa	p.A1273E	LRRC7_ENST00000035383.5_Missense_Mutation_p.A1268E|LRRC7_ENST00000415775.2_Missense_Mutation_p.A552E			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1268						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AAAATGCCTGCAGACTGGAGA	0.448000													11	83					0.000978159	0.00106607	0.387290	1	0
NINL	22981	broad.mit.edu	37	20	25459559	25459559	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:25459559C>A	ENST00000278886.6	-	16	2274	c.2201_splice	c.e16+1	p.R734_splice	NINL_ENST00000422516.1_Splice_Site_p.R734_splice	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	734					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						CTGGCTGGACCTGATCTGCTG	0.567000													11	34					2.31682e-05	2.68751e-05	0.479597	1	0
FAM47C	442444	broad.mit.edu	37	X	37027118	37027118	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37027118C>G	ENST00000358047.3	+	1	687	c.635C>G	c.(634-636)cCg>cGg	p.P212R		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	212										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGTCTCCGCCCGGAGCCTCCA	0.642000													16	47					0	0	0.539581	0	0
AJAP1	55966	broad.mit.edu	37	1	4772063	4772063	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:4772063G>T	ENST00000378191.4	+	2	514	c.133G>T	c.(133-135)Ggc>Tgc	p.G45C	AJAP1_ENST00000466761.1_3'UTR|AJAP1_ENST00000378190.3_Missense_Mutation_p.G45C	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	45					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TGAGGCCCTGGGCCCGGGGCC	0.726000													27	177					2.80507e-11	3.97236e-11	0.760397	1	0
NBEAL1	65065	broad.mit.edu	37	2	204058616	204058616	+	Silent	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:204058616C>G	ENST00000449802.1	+	46	7266	c.6933C>G	c.(6931-6933)ctC>ctG	p.L2311L		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2311							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TTCCTGAACTCAAGTCATTTT	0.348000													5	92					0	0	0.278610	0	0
SCAF1	58506	broad.mit.edu	37	19	50156582	50156582	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:50156582C>G	ENST00000360565.3	+	7	3060	c.2936C>G	c.(2935-2937)cCc>cGc	p.P979R		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	979					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		ACCCCGCCCCCCAAGGCAGCC	0.692000													6	10					0	0	0.278610	0	0
ZHX1	11244	broad.mit.edu	37	8	124267901	124267901	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:124267901C>A	ENST00000395571.3	-	3	903	c.286G>T	c.(286-288)Gta>Tta	p.V96L	ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Missense_Mutation_p.V96L|ZHX1_ENST00000522595.1_5'UTR|ZHX1_ENST00000522655.1_Missense_Mutation_p.V96L	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	96					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TTTAGCACTACATTGGGATGT	0.328000													30	47					3.11337e-16	5.01599e-16	0.769981	1	0
ATP6V0A1	535	broad.mit.edu	37	17	40653296	40653296	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:40653296C>T	ENST00000343619.4	+	17	2101	c.1978C>T	c.(1978-1980)Cgt>Tgt	p.R660C	ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.R660C|ATP6V0A1_ENST00000544137.1_Missense_Mutation_p.R306C|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.R667C|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.R660C|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.R617C|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.R617C	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	660					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		GGTCCTTCGCCGTCAGTATTT	0.413000													15	114					0	0	0.520397	0	0
GRID1	2894	broad.mit.edu	37	10	87482882	87482882	+	Silent	SNP	C	C	A	rs144860942	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:87482882C>A	ENST00000327946.7	-	12	1960	c.1875G>T	c.(1873-1875)gtG>gtT	p.V625V	GRID1_ENST00000536331.1_Silent_p.V196V	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	625						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CCATGGAGTTCACGGAAGATT	0.597000										Multiple Myeloma(13;0.14)			7	51					0.0477658	0.0490905	0.307466	1	0
OR10C1	442194	broad.mit.edu	37	6	29407861	29407861	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:29407861G>A	ENST00000444197.2	+	1	779	c.69G>A	c.(67-69)caG>caA	p.Q23Q	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CCGACCTCCAGGGCTTGCTCT	0.537000													26	96					0	0	0.729181	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841968	8841968	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:8841968G>A	ENST00000324060.2	+	1	653	c.578G>A	c.(577-579)tGt>tAt	p.C193Y		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCAGATACCTGTGCCTACGAG	0.562000													28	127					0	0	0.750413	0	0
TBX22	50945	broad.mit.edu	37	X	79286255	79286255	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:79286255T>A	ENST00000442340.1	+	9	1338	c.848T>A	c.(847-849)tTa>tAa	p.L283*	TBX22_ENST00000373291.1_Nonsense_Mutation_p.L283*|TBX22_ENST00000373296.3_Nonsense_Mutation_p.L403*|TBX22_ENST00000373294.5_Nonsense_Mutation_p.L403*	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	403					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TCTCAGTCTTTAGCCCCACTC	0.448000													70	167					0	0	0.870114	0	0
SOX10	6663	broad.mit.edu	37	22	38369659	38369659	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:38369659G>T	ENST00000396884.2	-	4	1526	c.1244C>A	c.(1243-1245)tCg>tAg	p.S415*	SOX10_ENST00000360880.2_Nonsense_Mutation_p.S415*|POLR2F_ENST00000405557.1_Intron|POLR2F_ENST00000407936.1_Intron	NM_006941.3	NP_008872.1	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	415						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity			NS(6)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|skin(2)	20	Melanoma(58;0.045)					GGCCTGGCCCGAGTGGCCATA	0.652000													15	42					8.28177e-16	1.32787e-15	0.557998	1	0
HERC3	8916	broad.mit.edu	37	4	89591020	89591020	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:89591020G>C	ENST00000402738.1	+	15	1882	c.1643G>C	c.(1642-1644)tGg>tCg	p.W548S	HERC3_ENST00000543130.1_5'UTR|HERC3_ENST00000264345.3_Missense_Mutation_p.W548S	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	548					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		GATAACTGGTGGTCTCAGGTA	0.373000													13	49					0	0	0.479597	0	0
PLXNB3	5365	broad.mit.edu	37	X	153033745	153033745	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153033745C>A	ENST00000538966.1	+	5	1468	c.1197C>A	c.(1195-1197)ccC>ccA	p.P399P	PLXNB3_ENST00000361971.5_Silent_p.P376P|PLXNB3_ENST00000538282.1_Silent_p.P29P|PLXNB3_ENST00000538776.1_Silent_p.P29P|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	376	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCACACCCCCAGCCCCATTG	0.672000													13	124					1.5739e-10	2.20082e-10	0.500413	1	0
NXF1	10482	broad.mit.edu	37	11	62563573	62563573	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:62563573C>G	ENST00000532297.1	-	17	2055	c.1426G>C	c.(1426-1428)Gtc>Ctc	p.V476L	NXF1_ENST00000294172.2_Missense_Mutation_p.V476L|NXF1_ENST00000531709.2_3'UTR			Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	476	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AAGGAATTGACGTCGTGCTGG	0.547000													16	42					0	0	0.575678	0	0
DRD4	1815	broad.mit.edu	37	11	640430	640430	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:640430T>C	ENST00000176183.5	+	4	1099	c.1087T>C	c.(1087-1089)Ttc>Ctc	p.F363L		NM_000797.3	NP_000788.2	P21917	DRD4_HUMAN	dopamine receptor D4	411					activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding			NS(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)	GACGCCCTTCTTCGTGGTGCA	0.726000													9	22					0	0	0.361761	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49325203	49325203	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:49325203C>T	ENST00000559471.1	-	4	886	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.R208Q	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	208										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						AATTTTTGATCGACTATCAGG	0.398000													16	145					0	0	0.624587	0	0
TRBV9	28586	broad.mit.edu	37	7	142239553	142239553	+	RNA	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:142239553G>A	ENST00000390363.2	-	0	373																											TGCTGGCACAGAAATACAAAG	0.537000													10	89					0	0	0.411799	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725383	140725383	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140725383G>C	ENST00000253812.6	+	1	1783	c.1783G>C	c.(1783-1785)Gac>Cac	p.D595H	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCGGTGGACAGAGACTC	0.692000													21	52					0	0	0.760397	0	0
AUTS2	26053	broad.mit.edu	37	7	70254798	70254798	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:70254798C>G	ENST00000342771.4	+	19	2917	c.2596C>G	c.(2596-2598)Ctg>Gtg	p.L866V	AUTS2_ENST00000406775.2_Missense_Mutation_p.L842V	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	866										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGTGAATGCCCTGGGACATAC	0.587000													8	83					0	0	0.307466	0	0
PCDH8	5100	broad.mit.edu	37	13	53420387	53420387	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:53420387G>T	ENST00000377942.3	-	1	2388	c.2185C>A	c.(2185-2187)Cgt>Agt	p.R729S	PCDH8_ENST00000338862.4_Missense_Mutation_p.R729S	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	729					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GGGCGGGAACGCTCCGGGCTT	0.716000													3	25					0.00909568	0.00946462	0.150653	1	0
KANSL1	284058	broad.mit.edu	37	17	44248858	44248858	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:44248858C>A	ENST00000262419.6	-	2	1122	c.652G>T	c.(652-654)Gaa>Taa	p.E218*	KANSL1_ENST00000575318.1_Nonsense_Mutation_p.E218*|KANSL1_ENST00000432791.1_Nonsense_Mutation_p.E218*|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000574590.1_Nonsense_Mutation_p.E218*|KANSL1_ENST00000572904.1_Nonsense_Mutation_p.E218*	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	218						MLL1 complex	protein binding										GTTGTGTGTTCTACATCAAGG	0.453000													24	326					9.65021e-13	1.4272e-12	0.750413	1	0
OBSCN	84033	broad.mit.edu	37	1	228494243	228494243	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:228494243G>A	ENST00000570156.2	+	55	14775	c.14701G>A	c.(14701-14703)Gcg>Acg	p.A4901T	OBSCN_ENST00000366709.4_Missense_Mutation_p.A1063T|OBSCN_ENST00000366707.4_Missense_Mutation_p.A1578T|OBSCN_ENST00000284548.11_Missense_Mutation_p.A3944T|OBSCN_ENST00000422127.1_Missense_Mutation_p.A3944T	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3944	IQ.|Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGCTGCACCGCGGAGCTGGT	0.632000													8	25					0	0	0.335167	0	0
FNDC1	84624	broad.mit.edu	37	6	159653941	159653941	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:159653941G>T	ENST00000297267.9	+	11	2597	c.2397G>T	c.(2395-2397)agG>agT	p.R799S	FNDC1_ENST00000340366.6_Missense_Mutation_p.R736S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	799						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACGGCGGAAGGCAGGCGGAGG	0.632000													7	10					2.0095e-06	2.42375e-06	0.248553	1	0
FCER1A	2205	broad.mit.edu	37	1	159277575	159277575	+	Silent	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:159277575A>G	ENST00000368115.1	+	6	726	c.627A>G	c.(625-627)ccA>ccG	p.P209P	FCER1A_ENST00000368114.1_Silent_p.P176P	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	209						integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TTTTTATCCCATTGTTGGTGG	0.413000													45	55					0	0	0.870114	0	0
SLC22A11	55867	broad.mit.edu	37	11	64323681	64323681	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:64323681G>C	ENST00000301891.4	+	1	584	c.210G>C	c.(208-210)ctG>ctC	p.L70L	SLC22A11_ENST00000377585.3_Silent_p.L70L|SLC22A11_ENST00000490834.1_3'UTR|SLC22A11_ENST00000377581.3_Silent_p.L70L	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	70					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	AGGCCCTTCTGACCATCTCCA	0.642000											OREG0004031	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	66	176					0	0	0.870114	0	0
RASAL3	64926	broad.mit.edu	37	19	15566966	15566966	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:15566966C>A	ENST00000343625.6	-	11	1750	c.1670G>T	c.(1669-1671)aGa>aTa	p.R557I		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	557	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						GTTCCGAAGTCTGGCCTGGTG	0.577000													7	69					0.000157383	0.000176428	0.278610	1	0
CABS1	85438	broad.mit.edu	37	4	71201760	71201760	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:71201760A>T	ENST00000273936.4	+	1	1063	c.1004A>T	c.(1003-1005)gAa>gTa	p.E335V		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	335						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACCTAGTGGAAGAATCATCT	0.398000													14	52					0	0	0.500413	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528596	6528596	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:6528596C>A	ENST00000377748.1	-	21	3028	c.2531G>T	c.(2530-2532)gGg>gTg	p.G844V	PLEKHG5_ENST00000377737.2_Missense_Mutation_p.G767V|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.G767V|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.G767V|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.G767V|PLEKHG5_ENST00000544978.1_Missense_Mutation_p.G767V|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.G846V|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.G836V|PLEKHG5_ENST00000377740.3_Intron|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.G823V|PLEKHG5_ENST00000377725.1_Missense_Mutation_p.G767V|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.G804V	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	823					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CAGCGTGTCCCCAGGCTCTAC	0.622000													18	54					1.50039e-11	2.14755e-11	0.608945	1	0
OR7G2	390882	broad.mit.edu	37	19	9212999	9212999	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:9212999C>A	ENST00000305456.2	-	1	983	c.984G>T	c.(982-984)agG>agT	p.R328S		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						GAGAAGGTATCCTCCCTATGA	0.433000													6	35					0.000442599	0.000490388	0.335167	1	0
CFH	3075	broad.mit.edu	37	1	196658664	196658664	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:196658664A>G	ENST00000367429.4	+	8	1319	c.1079A>G	c.(1078-1080)cAt>cGt	p.H360R	CFH_ENST00000439155.2_Missense_Mutation_p.H360R|CFH_ENST00000359637.2_Missense_Mutation_p.H296R	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	360	Sushi 6.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TGTGATGAACATTTTGAGACT	0.413000													53	81					0	0	0.870114	0	0
SHANK2	22941	broad.mit.edu	37	11	70331739	70331739	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:70331739C>T	ENST00000338508.4	-	32	4661	c.4662G>A	c.(4660-4662)aaG>aaA	p.K1554K	SHANK2_ENST00000423696.2_Silent_p.K1174K|SHANK2_ENST00000449833.2_Silent_p.K958K|SHANK2_ENST00000409161.1_Silent_p.K957K			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1174					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAATGATGGGCTTCATTTTTG	0.527000													93	240					0	0	0.870114	0	0
NCOR2	9612	broad.mit.edu	37	12	124824557	124824557	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:124824557G>A	ENST00000356219.3	-	38	5858	c.5703C>T	c.(5701-5703)gtC>gtT	p.V1901V	NCOR2_ENST00000404121.2_Silent_p.V1455V|NCOR2_ENST00000404621.1_Silent_p.V1884V|NCOR2_ENST00000429285.2_Silent_p.V1884V|NCOR2_ENST00000405201.1_Silent_p.V1894V|NCOR2_ENST00000397355.1_Silent_p.V1885V	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1905					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCCACCTCAGGACCGTGGGCG	0.622000													26	52					0	0	0.693898	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40295449	40295449	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:40295449G>A	ENST00000263791.5	+	23	3334	c.3291G>A	c.(3289-3291)gaG>gaA	p.E1097E	EIF2AK4_ENST00000382727.2_Silent_p.E1069E|EIF2AK4_ENST00000559311.1_3'UTR	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1097	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AAATATATGAGCACAACGAAG	0.473000													3	63					0	0	0.150653	0	0
RSBN1	54665	broad.mit.edu	37	1	114319928	114319928	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:114319928C>A	ENST00000261441.5	-	4	1625	c.1562G>T	c.(1561-1563)aGg>aTg	p.R521M		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	521						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTCTGGGACCTACACTGGAG	0.438000													17	83					1.45105e-14	2.23007e-14	0.539581	1	0
PXDNL	137902	broad.mit.edu	37	8	52322094	52322094	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:52322094G>T	ENST00000356297.4	-	17	2190	c.2090C>A	c.(2089-2091)cCg>cAg	p.P697Q	PXDNL_ENST00000543296.1_Missense_Mutation_p.P697Q	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	697					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GAGGGAGCGCGGGGACACCAA	0.612000													8	46					7.48243e-07	9.2251e-07	0.335167	1	0
NLGN4X	57502	broad.mit.edu	37	X	5811462	5811462	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:5811462G>T	ENST00000381095.3	-	6	2474	c.1847C>A	c.(1846-1848)cCa>cAa	p.P616Q	NLGN4X_ENST00000381092.1_Missense_Mutation_p.P616Q|NLGN4X_ENST00000381093.2_Missense_Mutation_p.P636Q|NLGN4X_ENST00000275857.6_Missense_Mutation_p.P616Q|NLGN4X_ENST00000538097.1_Missense_Mutation_p.P616Q	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	616					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TGTCATGTCTGGTGGAGGAAC	0.502000													26	105					5.82388e-19	9.68711e-19	0.870114	1	0
OR10J3	441911	broad.mit.edu	37	1	159284147	159284147	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:159284147C>A	ENST00000332217.5	-	1	302	c.303G>T	c.(301-303)caG>caT	p.Q101H		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					AGAAGAAGAGCTGAGTGGCAC	0.507000													47	50					8.86878e-18	1.46061e-17	0.870114	1	0
OR10R2	343406	broad.mit.edu	37	1	158449829	158449829	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:158449829G>T	ENST00000368152.1	+	1	162	c.162G>T	c.(160-162)ctG>ctT	p.L54L	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TTCTTTTTCTGTATCTAGTCA	0.438000													26	47					6.07407e-21	1.04959e-20	0.717897	1	0
ARNT2	9915	broad.mit.edu	37	15	80869267	80869267	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:80869267G>C	ENST00000533983.1	+	16	1880	c.1541G>C	c.(1540-1542)gGa>gCa	p.G514A	ARNT2_ENST00000303329.4_Missense_Mutation_p.G525A|ARNT2_ENST00000527771.1_Missense_Mutation_p.G514A			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	525					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TACTCCCAAGGAAGCCCATTT	0.572000													36	146					0	0	0.870114	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141034058	141034058	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:141034058C>A	ENST00000389328.4	-	18	2983	c.2969G>T	c.(2968-2970)cGa>cTa	p.R990L	TRAPPC9_ENST00000438773.2_Missense_Mutation_p.R892L|TRAPPC9_ENST00000389327.3_Missense_Mutation_p.R883L	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	892					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GGTGCTGACTCGGGTGAAAAA	0.517000													11	103					7.03913e-09	9.37145e-09	0.411799	1	0
LRRC7	57554	broad.mit.edu	37	1	70300462	70300462	+	Splice_Site	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:70300462G>T	ENST00000310961.5	+	7	819		c.e7-1		LRRC7_ENST00000035383.5_Splice_Site|LRRC7_ENST00000415775.2_Splice_Site|LRRC7_ENST00000370958.1_Splice_Site			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding	p.?(2)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CTCCTTTTTAGACTACCTGAT	0.358000													19	48					7.33532e-06	8.64427e-06	0.667858	1	0
BNC2	54796	broad.mit.edu	37	9	16552726	16552726	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:16552726G>T	ENST00000380672.4	-	5	528	c.471C>A	c.(469-471)ccC>ccA	p.P157P	BNC2_ENST00000380666.2_Silent_p.P157P|BNC2_ENST00000545497.1_Silent_p.P62P|BNC2_ENST00000380667.2_Silent_p.P90P	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CCACTTGGGTGGGGTGGTACA	0.542000													20	80					1.1804e-14	1.83099e-14	0.667858	1	0
VAX2	25806	broad.mit.edu	37	2	71148413	71148413	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:71148413C>T	ENST00000234392.2	+	2	465	c.433C>T	c.(433-435)Cag>Tag	p.Q145*		NM_012476.2	NP_036608.1	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	145					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	7						CTCCGAGACCCAGGTAAGAGA	0.637000													4	46					0	0	0.184627	0	0
DOT1L	84444	broad.mit.edu	37	19	2214581	2214581	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:2214581T>G	ENST00000398665.3	+	19	1945	c.1909T>G	c.(1909-1911)Tgc>Ggc	p.C637G	AC004490.1_ENST00000585593.1_RNA|DOT1L_ENST00000586024.1_3'UTR	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	637						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGAGGCACTGCCTGGAGCT	0.647000													3	42					0	0	0.115264	0	0
GLB1L2	89944	broad.mit.edu	37	11	134212791	134212791	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:134212791A>C	ENST00000535456.2	+	2	418	c.230A>C	c.(229-231)tAc>tCc	p.Y77S	GLB1L2_ENST00000339772.7_Missense_Mutation_p.Y77S|GLB1L2_ENST00000389881.3_Missense_Mutation_p.Y77S	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	77					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CCCAGGGAGTACTGGAGGGAC	0.622000													37	111					0	0	0.847076	0	0
SLC26A10	65012	broad.mit.edu	37	12	58019102	58019102	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:58019102G>C	ENST00000320442.4	+	12	1773	c.1462G>C	c.(1462-1464)Gtg>Ctg	p.V488L	SLC26A10_ENST00000490243.1_Splice_Site|SLC26A10_ENST00000379218.2_3'UTR	NM_133489.2	NP_597996.2	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	488	STAS.					integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					AGTGGTGCAGGTGAGGGAGAG	0.567000													58	49					0	0	0.870114	0	0
UBE2L6	9246	broad.mit.edu	37	11	57319948	57319948	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:57319948C>T	ENST00000340573.4	-	4	753	c.147G>A	c.(145-147)ccG>ccA	p.P49P	UBE2L6_ENST00000287156.4_Silent_p.P115P	NM_198183.2	NP_937826.1	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6	115					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity	p.P115P(1)		large_intestine(1)|lung(3)|ovary(1)	5						CCCTGATATTCGGTCTATTCA	0.582000													28	259					0	0	0.788014	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471728	61471728	+	Silent	SNP	C	C	A	rs141979762		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:61471728C>A	ENST00000398019.2	+	8	1327	c.1002C>A	c.(1000-1002)acC>acA	p.T334T	SERPINB7_ENST00000336429.2_Silent_p.T334T|SERPINB7_ENST00000546027.1_Silent_p.T334T|SERPINB7_ENST00000540675.1_Silent_p.T317T	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	334					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AGGAGGGCACCGAGGCTACTG	0.473000													8	21					5.68852e-11	8.00474e-11	0.307466	1	0
ORC4	5000	broad.mit.edu	37	2	148712948	148712948	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:148712948T>A	ENST00000535373.1	-	8	836	c.404A>T	c.(403-405)aAc>aTc	p.N135I	ORC4_ENST00000392857.4_Missense_Mutation_p.N135I|ORC4_ENST00000392858.1_Missense_Mutation_p.N135I|ORC4_ENST00000264169.2_Missense_Mutation_p.N135I|ORC4_ENST00000542387.1_5'UTR|ORC4_ENST00000536575.1_Missense_Mutation_p.N51I|ORC4_ENST00000540442.1_Missense_Mutation_p.N61I	NM_001190879.2	NP_001177808.1	O43929	ORC4_HUMAN	origin recognition complex, subunit 4	135					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	14						AAATGAAAGGTTTTCAGCAAA	0.279000													3	20					0	0	0.150653	0	0
PCDH15	65217	broad.mit.edu	37	10	55581672	55581672	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:55581672G>T	ENST00000361849.3	-	34	6214	c.5820C>A	c.(5818-5820)aaC>aaA	p.N1940K	PCDH15_ENST00000320301.6_Missense_Mutation_p.N1938K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395432.2_Missense_Mutation_p.N1898K|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.N1915K|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000373957.3_Missense_Mutation_p.N792K|PCDH15_ENST00000395430.1_Missense_Mutation_p.N1935K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.N1869K	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1938					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CGACAATATTGTTCAAACTCC	0.358000										HNSCC(58;0.16)			17	53					2.35188e-11	3.35193e-11	0.539581	1	0
MT3	4504	broad.mit.edu	37	16	56623855	56623855	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:56623855C>A	ENST00000570176.1	+	2	156	c.105C>A	c.(103-105)tgC>tgA	p.C35*	MT3_ENST00000200691.4_Intron|MT3_ENST00000566576.1_Intron|MT3_ENST00000565838.1_Intron|MT3_ENST00000561640.1_Intron			P25713	MT3_HUMAN	metallothionein 3	35	Alpha.				cell proliferation|cellular metal ion homeostasis|removal of superoxide radicals|response to hypoxia	synaptic vesicle	antioxidant activity|copper ion binding|zinc ion binding			central_nervous_system(1)|large_intestine(1)	2						AGAGTGAGTGCGGGGACCCTT	0.657000													5	47					0.184627	0.187153	0.184627	1	0
CTTN	2017	broad.mit.edu	37	11	70281797	70281797	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:70281797C>T	ENST00000376561.3	+	18	1896	c.1725C>T	c.(1723-1725)tgC>tgT	p.C575C	CTTN_ENST00000538675.1_Silent_p.C296C|CTTN_ENST00000301843.8_3'UTR|CTTN_ENST00000346329.3_3'UTR	NM_001184740.1	NP_001171669.1	Q14247	SRC8_HUMAN	cortactin	0						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		ACAGGAGCTGCCATGTCAGAT	0.572000													15	40					0	0	0.479597	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12908140	12908140	+	Translation_Start_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:12908140C>A	ENST00000317869.6	-	2	228	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						CGTTGCTGGCCATTGTGTTGG	0.483000													9	153					0.00829132	0.00870915	0.361761	1	0
DNTT	1791	broad.mit.edu	37	10	98064405	98064405	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:98064405T>A	ENST00000419175.1	+	1	321	c.151T>A	c.(151-153)Ttc>Atc	p.F51I	DNTT_ENST00000371174.2_Missense_Mutation_p.F51I|RP11-35J23.1_ENST00000454484.2_RNA	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	51	BRCT.			F -> L (in Ref. 4; BAD97037).	DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CCGCAGAGCGTTCCTCATGGA	0.493000													7	25					0	0	0.335167	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004018	102004018	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:102004018G>T	ENST00000372735.1	+	4	680	c.95G>T	c.(94-96)gGt>gTt	p.G32V	BHLHB9_ENST00000457056.1_Missense_Mutation_p.G32V|BHLHB9_ENST00000361229.4_Missense_Mutation_p.G32V|BHLHB9_ENST00000448867.1_Missense_Mutation_p.G32V|BHLHB9_ENST00000447531.1_Missense_Mutation_p.G32V			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	32						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GAGGCTACTGGTGTTGTTAGG	0.488000													27	119					4.59853e-10	6.29819e-10	0.693898	1	0
ATXN2L	11273	broad.mit.edu	37	16	28844165	28844165	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:28844165G>T	ENST00000336783.4	+	13	1783	c.1616G>T	c.(1615-1617)cGa>cTa	p.R539L	RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000325215.6_Missense_Mutation_p.R539L|ATXN2L_ENST00000564304.1_Missense_Mutation_p.R545L|ATXN2L_ENST00000395547.2_Missense_Mutation_p.R539L|ATXN2L_ENST00000570200.1_Missense_Mutation_p.R539L|ATXN2L_ENST00000382686.4_Missense_Mutation_p.R539L|ATXN2L_ENST00000340394.8_Missense_Mutation_p.R539L	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	539						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						GAACAGAAACGATTCCAACTG	0.428000													9	30					3.07112e-06	3.65792e-06	0.387290	1	0
FHOD3	80206	broad.mit.edu	37	18	34322707	34322707	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:34322707C>A	ENST00000257209.4	+	19	3364	c.3242C>A	c.(3241-3243)gCa>gAa	p.A1081E	FHOD3_ENST00000590592.1_Missense_Mutation_p.A1256E|FHOD3_ENST00000359247.4_Missense_Mutation_p.A1064E|FHOD3_ENST00000445677.1_Missense_Mutation_p.A1043E|FHOD3_ENST00000591635.1_Missense_Mutation_p.A277E|FHOD3_ENST00000592128.1_Missense_Mutation_p.A60E	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1064	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AAGGAAGTAGCAGAACCACTC	0.378000													73	127					1.92865e-43	3.62368e-43	0.870114	1	0
CHRD	8646	broad.mit.edu	37	3	184103942	184103942	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:184103942G>A	ENST00000204604.1	+	15	2173	c.1927G>A	c.(1927-1929)Ggg>Agg	p.G643R	CHRD_ENST00000450923.1_Missense_Mutation_p.G643R|CHRD_ENST00000545352.1_Missense_Mutation_p.G273R|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000348986.3_Missense_Mutation_p.G603R	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	643	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGCTCCGAGGGCAGGTAGG	0.627000													9	30					0	0	0.307466	0	0
ZNF622	90441	broad.mit.edu	37	5	16465192	16465192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:16465192C>A	ENST00000308683.2	-	1	709	c.583G>T	c.(583-585)Gag>Tag	p.E195*		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	195	Glu-rich.					cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CTGTCCTCCTCCTGCTGCTTT	0.612000													58	332					2.02627e-32	3.7232e-32	0.870114	1	0
FEN1	2237	broad.mit.edu	37	11	61563832	61563832	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:61563832A>T	ENST00000305885.2	+	2	1412	c.999A>T	c.(997-999)caA>caT	p.Q333H	FADS2_ENST00000574708.1_Intron	NM_004111.5	NP_004102.1	P39748	FEN1_HUMAN	flap structure-specific endonuclease 1	333					base-excision repair|DNA replication, removal of RNA primer|double-strand break repair|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|UV protection	mitochondrion|nucleolus|nucleoplasm	5'-3' exonuclease activity|5'-flap endonuclease activity|damaged DNA binding|double-stranded DNA binding|double-stranded DNA specific exodeoxyribonuclease activity|metal ion binding|protein binding|ribonuclease H activity			endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						AGAGCCGCCAAGGCAGCACCC	0.537000								Editing and processing nucleases					10	24					0	0	0.387290	0	0
OGDHL	55753	broad.mit.edu	37	10	50953480	50953480	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:50953480C>A	ENST00000374103.4	-	12	1624	c.1539G>T	c.(1537-1539)atG>atT	p.M513I	OGDHL_ENST00000419399.1_Missense_Mutation_p.M456I|OGDHL_ENST00000432695.1_Missense_Mutation_p.M304I	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	513					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCTGCTTGTACATGAGCGGCT	0.607000													15	53					5.3912e-06	6.38709e-06	0.539581	1	0
GGH	8836	broad.mit.edu	37	8	63927937	63927937	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:63927937T>A	ENST00000260118.6	-	9	1313	c.911A>T	c.(910-912)tAt>tTt	p.Y304F		NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	304	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	ATTTCCAGTATAAATTGGACT	0.279000													12	30					0	0	0.435327	0	0
GRIK3	2899	broad.mit.edu	37	1	37337950	37337950	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:37337950G>T	ENST00000373091.3	-	4	587	c.571C>A	c.(571-573)Ctc>Atc	p.L191I	GRIK3_ENST00000373093.4_Missense_Mutation_p.L191I	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	191					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GCCATGATGAGCTCCTGCAGT	0.567000													8	76					3.07112e-06	3.65792e-06	0.387290	1	0
RBMXL1	494115	broad.mit.edu	37	1	89448627	89448627	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:89448627G>A	ENST00000399794.2	-	3	1598	c.883C>T	c.(883-885)Cca>Tca	p.P295S	CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.P295S|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000370491.3_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	295	Ser-rich.						nucleotide binding|RNA binding										CGTGTAAGTGGAGCACTACGT	0.473000													46	166					0	0	0.870114	0	0
COQ2	27235	broad.mit.edu	37	4	84205934	84205934	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:84205934G>A	ENST00000311469.4	-	1	133	c.134C>T	c.(133-135)cCc>cTc	p.P45L	COQ2_ENST00000439031.2_Missense_Mutation_p.P8L	NM_015697.7	NP_056512.5	Q96H96	COQ2_HUMAN	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	0					glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)	8		Hepatocellular(203;0.114)				GGTGAGGCCGGGACGAGCTCG	0.736000													3	17					0	0	0.115264	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751587	19751587	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:19751587G>A	ENST00000400113.3	-	4	640	c.536C>T	c.(535-537)aCg>aTg	p.T179M		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	179					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CACCACGGCCGTGGAGACCTG	0.552000													27	167					0	0	0.729181	0	0
METTL13	51603	broad.mit.edu	37	1	171752883	171752883	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:171752883C>T	ENST00000361735.3	+	2	423	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L	METTL13_ENST00000367737.5_Silent_p.L53L|METTL13_ENST00000362019.3_5'UTR|METTL13_ENST00000458517.1_Silent_p.L52L	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	53							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TCTCCAGGTGCTGGTGATTGG	0.458000													10	82					0	0	0.457914	0	0
VPS13D	55187	broad.mit.edu	37	1	12429654	12429654	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:12429654G>A	ENST00000358136.3	+	54	10835	c.10705G>A	c.(10705-10707)Gca>Aca	p.A3569T	VPS13D_ENST00000356315.4_Missense_Mutation_p.A3544T|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3568					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTTAAAGGGGCAGGGTCCTC	0.443000													36	98					0	0	0.859065	0	0
TNRC6B	23112	broad.mit.edu	37	22	40708543	40708543	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:40708543A>C	ENST00000454349.2	+	18	4681	c.4470A>C	c.(4468-4470)caA>caC	p.Q1490H	TNRC6B_ENST00000301923.9_Missense_Mutation_p.Q686H|TNRC6B_ENST00000335727.8_Missense_Mutation_p.Q1380H|TNRC6B_ENST00000402203.1_Missense_Mutation_p.Q686H	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1490					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						AAGGTATCCAAAACATTGACC	0.443000													30	83					0	0	0.769981	0	0
CD209	30835	broad.mit.edu	37	19	7810766	7810766	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:7810766C>T	ENST00000315599.7	-	4	408	c.386G>A	c.(385-387)cGg>cAg	p.R129Q	CD209_ENST00000394161.5_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.R129Q|CD209_ENST00000601951.1_Missense_Mutation_p.R105Q|CD209_ENST00000601256.1_Missense_Mutation_p.R105Q|CD209_ENST00000301357.8_Missense_Mutation_p.R85Q|CD209_ENST00000204801.8_Missense_Mutation_p.R85Q|CD209_ENST00000315591.8_Missense_Mutation_p.R105Q|CD209_ENST00000593660.1_Missense_Mutation_p.R105Q|CD209_ENST00000394173.4_Intron|CD209_ENST00000593821.1_Missense_Mutation_p.R85Q|CD209_ENST00000602261.1_Missense_Mutation_p.R129Q	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						AGCCTTCAGCCGGGTCAGCTC	0.567000													5	223					0	0	0.184627	0	0
ART3	419	broad.mit.edu	37	4	77025109	77025109	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:77025109C>A	ENST00000355810.4	+	9	1076	c.957C>A	c.(955-957)ccC>ccA	p.P319P	ART3_ENST00000341029.5_Silent_p.P319P|ART3_ENST00000349321.3_Silent_p.P319P	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	319					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCCTTGAACCCACCCAAATAC	0.368000													6	78					1.76689e-08	2.31992e-08	0.335167	1	0
E2F8	79733	broad.mit.edu	37	11	19259535	19259535	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:19259535C>G	ENST00000527884.1	-	3	392	c.160G>C	c.(160-162)Gga>Cga	p.G54R	E2F8_ENST00000250024.4_Missense_Mutation_p.G54R|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	54					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CACGGCTCTCCCTGAGAGCCT	0.517000													12	73					0	0	0.411799	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													3	40					0	0	0.115264	0	0
TP53	7157	broad.mit.edu	37	17	7574027	7574027	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:7574027C>A	ENST00000269305.4	-	10	1189	c.1000G>T	c.(1000-1002)Ggg>Tgg	p.G334W	TP53_ENST00000445888.2_Missense_Mutation_p.G334W|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_3'UTR	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	334	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		G -> V (in sporadic cancers; somatic mutation).|G -> W (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.I332fs*5(1)|p.G334W(1)|p.?(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCTCACGCCCACGGATCTGC	0.522000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	20					0.000978159	0.00106607	0.387290	1	0
CSMD3	114788	broad.mit.edu	37	8	113353811	113353811	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:113353811C>A	ENST00000297405.5	-	42	6791	c.6547G>T	c.(6547-6549)Ggt>Tgt	p.G2183C	CSMD3_ENST00000455883.2_Missense_Mutation_p.G2079C|CSMD3_ENST00000343508.3_Missense_Mutation_p.G2143C|CSMD3_ENST00000352409.3_Missense_Mutation_p.G2113C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2183	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTTGAGGACCACTAAGCCGG	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	93					0.010729	0.0111295	0.387290	1	0
CCIN	881	broad.mit.edu	37	9	36170865	36170865	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:36170865G>T	ENST00000335119.2	+	1	1477	c.1366G>T	c.(1366-1368)Gtc>Ttc	p.V456F		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	456					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TGGGGACGTGGTCCAGTGTAT	0.557000													7	99					1.06961e-07	1.37463e-07	0.278610	1	0
MAPT	4137	broad.mit.edu	37	17	44073922	44073922	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:44073922C>A	ENST00000344290.5	+	11	2041	c.1719C>A	c.(1717-1719)tcC>tcA	p.S573S	MAPT_ENST00000334239.8_Silent_p.S180S|MAPT_ENST00000340799.5_Silent_p.S209S|MAPT_ENST00000347967.5_Silent_p.S144S|MAPT_ENST00000571987.1_Silent_p.S555S|MAPT_ENST00000570299.1_3'UTR|MAPT_ENST00000446361.3_Silent_p.S180S|MAPT_ENST00000262410.5_Silent_p.S555S|MAPT_ENST00000351559.5_Silent_p.S238S|MAPT_ENST00000431008.3_Silent_p.S238S|MAPT_ENST00000415613.2_Silent_p.S573S|MAPT_ENST00000574436.1_Silent_p.S238S|MAPT_ENST00000576518.1_Silent_p.S169S|MAPT_ENST00000420682.2_Silent_p.S209S|MAPT_ENST00000535772.1_Silent_p.S238S	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	555					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CGCCGTCTTCCGCCAAGAGCC	0.662000													6	39					0.00448238	0.00475318	0.307466	1	0
SSX2IP	117178	broad.mit.edu	37	1	85124142	85124142	+	Missense_Mutation	SNP	C	C	T	rs147688962	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:85124142C>T	ENST00000437941.2	-	8	1208	c.856G>A	c.(856-858)Gat>Aat	p.D286N	SSX2IP_ENST00000603677.1_Intron|SSX2IP_ENST00000342203.3_Missense_Mutation_p.D313N|SSX2IP_ENST00000370612.4_Missense_Mutation_p.D313N|SSX2IP_ENST00000605755.1_Missense_Mutation_p.D286N	NM_001166295.1|NM_001166417.1	NP_001159767.1|NP_001159889.1	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting protein	313					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TCTTCAACATCGGAAATAACC	0.453000													4	13					0	0	0.150653	0	0
ART3	419	broad.mit.edu	37	4	77025108	77025108	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:77025108C>A	ENST00000355810.4	+	9	1075	c.956C>A	c.(955-957)cCc>cAc	p.P319H	ART3_ENST00000341029.5_Missense_Mutation_p.P319H|ART3_ENST00000349321.3_Missense_Mutation_p.P319H	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	319					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATCCTTGAACCCACCCAAATA	0.368000													5	80					3.09899e-07	3.88538e-07	0.307466	1	0
PIWIL4	143689	broad.mit.edu	37	11	94320403	94320403	+	Missense_Mutation	SNP	G	G	A	rs144295355	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:94320403G>A	ENST00000299001.6	+	7	1115	c.904G>A	c.(904-906)Gtc>Atc	p.V302I	RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	302	PAZ.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGGCTCATTGTCCTTACAAG	0.433000													18	61					0	0	0.575678	0	0
TMEFF2	23671	broad.mit.edu	37	2	192863880	192863880	+	Silent	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:192863880A>T	ENST00000392314.1	-	6	982	c.591T>A	c.(589-591)tcT>tcA	p.S197S	TMEFF2_ENST00000487771.1_5'UTR|AC098617.1_ENST00000428980.2_RNA|AC098617.1_ENST00000424116.2_RNA|TMEFF2_ENST00000272771.5_Silent_p.S197S			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	197	Kazal-like 2.					extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			ATTTCCCATCAGAAGCGCAGA	0.368000													12	38					0	0	0.411799	0	0
CAPN6	827	broad.mit.edu	37	X	110489915	110489915	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:110489915G>C	ENST00000324068.1	-	13	1983	c.1816C>G	c.(1816-1818)Cgt>Ggt	p.R606G	CAPN6_ENST00000541758.1_Missense_Mutation_p.R351G	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	606	C2.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TTCAGATCACGGCAGTCGCTG	0.507000													28	72					0	0	0.740014	0	0
FAM47C	442444	broad.mit.edu	37	X	37026700	37026700	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37026700C>A	ENST00000358047.3	+	1	269	c.217C>A	c.(217-219)Cgt>Agt	p.R73S		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	73										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGTTTGTCGCCGTGACGAGTT	0.527000													17	83					8.28177e-16	1.32787e-15	0.557998	1	0
PLEKHH3	79990	broad.mit.edu	37	17	40823464	40823464	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:40823464C>T	ENST00000293349.6	-	8	1619	c.1189G>A	c.(1189-1191)Gcg>Acg	p.A397T	PLEKHH3_ENST00000412503.1_Missense_Mutation_p.A397T|PLEKHH3_ENST00000591022.1_Missense_Mutation_p.A397T|PLEKHH3_ENST00000456950.2_5'UTR			Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	397	MyTH4.				signal transduction	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|skin(2)	13		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TGGCTCAACGCGGAAATCTCC	0.677000													5	57					0	0	0.248553	0	0
SLC5A1	6523	broad.mit.edu	37	22	32480562	32480562	+	Silent	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:32480562A>G	ENST00000266088.4	+	8	1051	c.801A>G	c.(799-801)cgA>cgG	p.R267R	SLC5A1_ENST00000543737.1_Silent_p.R140R	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	267					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						ACATCTTCCGAGATCCCCTCA	0.512000													26	47					0	0	0.717897	0	0
NOS2	4843	broad.mit.edu	37	17	26096027	26096027	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:26096027G>A	ENST00000313735.6	-	17	2243	c.2010C>T	c.(2008-2010)cgC>cgT	p.R670R		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	670	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CGGCCCAGCTGCGGAAGGCGT	0.607000													9	53					0	0	0.387290	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917845	48917845	+	Missense_Mutation	SNP	C	C	A	rs144416262		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:48917845C>A	ENST00000311378.4	+	2	1724	c.1196C>A	c.(1195-1197)gCg>gAg	p.A399E	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.A306E|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	399	BPTI/Kunitz inhibitor 2.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AAAGCCTACGCGCCTCGCTGG	0.642000													20	28					4.35082e-09	5.80399e-09	0.592651	1	0
PABPC1L	80336	broad.mit.edu	37	20	43538805	43538805	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:43538805C>T	ENST00000255136.3	+	1	103	c.21C>T	c.(19-21)ggC>ggT	p.G7G	PABPC1L_ENST00000217073.2_Silent_p.G7G|PABPC1L_ENST00000537323.1_Silent_p.G7G|PABPC1L_ENST00000217074.4_Silent_p.G7G	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	7							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						GCGGTTCTGGCTACCCGCTTG	0.697000													4	6					0	0	0.150653	0	0
SORCS1	114815	broad.mit.edu	37	10	108459130	108459130	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:108459130C>A	ENST00000263054.6	-	9	1262	c.1255G>T	c.(1255-1257)Gat>Tat	p.D419Y	SORCS1_ENST00000344440.6_Missense_Mutation_p.D419Y	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	419						integral to membrane	neuropeptide receptor activity|protein binding	p.D419Y(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGATTCTCATCGGTGCTGATA	0.468000													10	49					1.49906e-05	1.74194e-05	0.457914	1	0
SCN7A	6332	broad.mit.edu	37	2	167289148	167289148	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:167289148C>G	ENST00000409855.1	-	15	2398	c.2272G>C	c.(2272-2274)Gga>Cga	p.G758R		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	758					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TAGTTTATTCCTTTTTTAATT	0.348000													7	22					0	0	0.278610	0	0
PLSCR5	389158	broad.mit.edu	37	3	146318159	146318159	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:146318159G>T	ENST00000443512.1	-	2	1108	c.105C>A	c.(103-105)aaC>aaA	p.N35K	PLSCR5_ENST00000482567.1_Missense_Mutation_p.N35K|PLSCR5_ENST00000492200.1_Missense_Mutation_p.N35K	NM_001085420.1	NP_001078889.1	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	35										endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						GCCATGCTTGGTTCCCTGGAT	0.512000													3	13					0.00024832	0.000277902	0.150653	1	0
SNRNP200	23020	broad.mit.edu	37	2	96943564	96943564	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:96943564G>A	ENST00000323853.5	-	40	5812	c.5735C>T	c.(5734-5736)aCg>aTg	p.T1912M	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1912	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						GATTTCCTCCGTATCTGACTG	0.512000													35	69					0	0	0.834066	0	0
DCTN4	51164	broad.mit.edu	37	5	150111016	150111016	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:150111016T>A	ENST00000447998.2	-	6	688	c.573A>T	c.(571-573)ccA>ccT	p.P191P	DCTN4_ENST00000446090.2_Silent_p.P198P|DCTN4_ENST00000424236.1_Silent_p.P134P	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	191						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACCAGCTCGTGGTCGCTGAA	0.388000													7	35					0	0	0.361761	0	0
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	T	A	rs17851045		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:25380275T>A	ENST00000311936.3	-	3	374	c.183A>T	c.(181-183)caA>caT	p.Q61H	KRAS_ENST00000256078.4_Missense_Mutation_p.Q61H|KRAS_ENST00000557334.1_Intron	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	61			Q -> H (in lung carcinoma; dbSNP:rs17851045).|Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(153)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423000	Q61H(CL11_LARGE_INTESTINE)|Q61H(HS766T_PANCREAS)|Q61H(NCIH1155_LUNG)|Q61H(NCIH460_LUNG)|Q61H(T3M4_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			41	39					0	0	0.870114	0	0
ANKRD36	375248	broad.mit.edu	37	2	97911222	97911222	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:97911222G>T	ENST00000420699.2	+	71	5142	c.4898G>T	c.(4897-4899)aGa>aTa	p.R1633I	ANKRD36_ENST00000461153.2_Missense_Mutation_p.R1633I	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1633										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TACCATTGTAGACTGAATGCT	0.443000													20	82					2.21704e-12	3.25003e-12	0.639603	1	0
SETBP1	26040	broad.mit.edu	37	18	42530719	42530719	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:42530719G>C	ENST00000282030.5	+	4	1710	c.1414G>C	c.(1414-1416)Gag>Cag	p.E472Q		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	472						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TAAAATGATAGAGAATGAGTC	0.478000									Schinzel-Giedion syndrome				41	68					0	0	0.870114	0	0
KRTAP3-3	85293	broad.mit.edu	37	17	39150240	39150240	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:39150240G>T	ENST00000391586.1	-	1	145	c.110C>A	c.(109-111)cCa>cAa	p.P37Q		NM_033185.2	NP_149441.1	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	37	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			lung(2)|prostate(2)	4		Breast(137;0.00043)				AACTGTGTGTGGGCAGGTGCT	0.632000													15	214					1.55469e-16	2.51085e-16	0.654019	1	0
C2orf16	84226	broad.mit.edu	37	2	27800825	27800825	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:27800825G>T	ENST00000408964.2	+	1	1437	c.1386G>T	c.(1384-1386)ggG>ggT	p.G462G		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	462										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AATCTCCAGGGACAACCCCAG	0.468000													18	73					2.94398e-08	3.85027e-08	0.557998	1	0
AHNAK	79026	broad.mit.edu	37	11	62294898	62294898	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:62294898C>G	ENST00000378024.4	-	5	7265	c.6991G>C	c.(6991-6993)Gat>Cat	p.D2331H	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2331					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GCAGAAACATCAACATCTCCT	0.453000													44	171					0	0	0.870114	0	0
OR5K1	26339	broad.mit.edu	37	3	98188603	98188603	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:98188603C>G	ENST00000332650.5	+	1	280	c.183C>G	c.(181-183)atC>atG	p.I61M		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CAATGTACATCTTTCTGGGAA	0.438000													63	166					0	0	0.870114	0	0
GPR50	9248	broad.mit.edu	37	X	150349605	150349605	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:150349605C>A	ENST00000218316.3	+	2	1619	c.1550C>A	c.(1549-1551)aCt>aAt	p.T517N		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	517	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					GAGCCCACCACTGCTGACTAT	0.612000													57	257					1.31171e-36	2.44388e-36	0.870114	1	0
MYBPC3	4607	broad.mit.edu	37	11	47369005	47369005	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:47369005G>T	ENST00000545968.1	-	9	931	c.877C>A	c.(877-879)Ctg>Atg	p.L293M	MYBPC3_ENST00000256993.4_Missense_Mutation_p.L293M|MYBPC3_ENST00000399249.2_Missense_Mutation_p.L293M	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	293					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		CTGAAGTCCAGAATCCCAGTG	0.577000													5	13					2.0095e-06	2.42375e-06	0.248553	1	0
B4GALT5	9334	broad.mit.edu	37	20	48257133	48257133	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:48257133C>A	ENST00000371711.4	-	6	863	c.676G>T	c.(676-678)Gat>Tat	p.D226Y		NM_004776.3	NP_004767.1	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	226					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			CAGTCCCAATCCAAGTCTTTC	0.393000													20	33					1.10513e-12	1.62721e-12	0.624587	1	0
OR4M1	441670	broad.mit.edu	37	14	20248946	20248946	+	Silent	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:20248946T>C	ENST00000315957.4	+	1	546	c.465T>C	c.(463-465)caT>caC	p.H155H		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTTCATTCATTCTATAATAC	0.502000													43	211					0	0	0.853193	0	0
ABCB11	8647	broad.mit.edu	37	2	169791858	169791858	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:169791858C>G	ENST00000263817.6	-	23	3016	c.2892G>C	c.(2890-2892)gaG>gaC	p.E964D		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	964	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CCAGCTCAGTCTCAAGTGCTT	0.438000													17	123					0	0	0.575678	0	0
FBLN2	2199	broad.mit.edu	37	3	13679066	13679066	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:13679066T>A	ENST00000404922.3	+	18	3462	c.3343T>A	c.(3343-3345)Tgc>Agc	p.C1115S	FBLN2_ENST00000535798.1_Missense_Mutation_p.C1094S|FBLN2_ENST00000492059.1_Missense_Mutation_p.C1115S|FBLN2_ENST00000295760.7_Missense_Mutation_p.C1068S	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	1068	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CTGCAGGAAGTGCGAGCGCAC	0.657000													9	30					0	0	0.307466	0	0
FAM102A	399665	broad.mit.edu	37	9	130706925	130706925	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:130706925C>A	ENST00000373095.1	-	10	1453	c.1078G>T	c.(1078-1080)Gcc>Tcc	p.A360S	FAM102A_ENST00000373084.4_Missense_Mutation_p.A218S|FAM102A_ENST00000300434.3_5'UTR	NM_001035254.2	NP_001030331.1	Q5T9C2	F102A_HUMAN	family with sequence similarity 102, member A	360										breast(1)|cervix(1)|large_intestine(3)|lung(1)|ovary(4)	10						CTCAGCGTGGCAGAGCCATCG	0.682000													7	33					0.010729	0.0111295	0.387290	1	0
BAGE2	85319	broad.mit.edu	37	21	11039050	11039050	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:11039050C>A	ENST00000470054.1	-	0	1153									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTCAGAGTCCATCAATCCAG	0.378000													13	256					0.00136819	0.00147668	0.411799	1	0
SORCS3	22986	broad.mit.edu	37	10	106737136	106737136	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:106737136T>C	ENST00000369701.3	+	4	1066	c.839T>C	c.(838-840)aTc>aCc	p.I280T		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	280						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGCATATTGATCAGCTCAGAC	0.448000													4	83					0	0	0.184627	0	0
SEMA3E	9723	broad.mit.edu	37	7	83032093	83032093	+	Splice_Site	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:83032093C>T	ENST00000307792.3	-	10	1466		c.e10-1		SEMA3E_ENST00000427262.1_Splice_Site	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E						axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AAAAATATTACTGAAAAATAC	0.398000													7	17					0	0	0.278610	0	0
HK1	3098	broad.mit.edu	37	10	71103678	71103678	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:71103678G>A	ENST00000448642.2	+	7	653	c.264G>A	c.(262-264)cgG>cgA	p.R88R	HK1_ENST00000359426.6_Silent_p.R53R|HK1_ENST00000298649.3_Silent_p.R52R|HK1_ENST00000360289.2_Silent_p.R41R|HK1_ENST00000494253.1_3'UTR|HK1_ENST00000404387.2_Silent_p.R57R			P19367	HXK1_HUMAN	hexokinase 1	53	Glucose-6-phosphate 1 binding.|Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						GCCTCTCCCGGGATTTTAATC	0.478000													15	108					0	0	0.520397	0	0
HOXD10	3236	broad.mit.edu	37	2	176982052	176982052	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:176982052A>C	ENST00000249501.4	+	1	746	c.491A>C	c.(490-492)cAa>cCa	p.Q164P	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	164						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGGAAAACCCAAGAGTACAAT	0.587000													19	120					0	0	0.639603	0	0
GPR50	9248	broad.mit.edu	37	X	150349877	150349877	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:150349877G>T	ENST00000218316.3	+	2	1891	c.1822G>T	c.(1822-1824)Gtt>Ttt	p.V608F		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	608	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTATTGATGTTGAAGATGA	0.468000													26	272					5.77227e-19	9.62526e-19	0.729181	1	0
OR1L6	392390	broad.mit.edu	37	9	125512817	125512817	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:125512817T>A	ENST00000373684.1	+	1	799	c.799T>A	c.(799-801)Tct>Act	p.S267T	OR1L6_ENST00000304720.2_Missense_Mutation_p.S231T			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CAGAATCCCCTCTGCAGCCGG	0.507000													6	21					0	0	0.307466	0	0
PEG3	5178	broad.mit.edu	37	19	57328222	57328222	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:57328222C>T	ENST00000326441.9	-	10	1951	c.1588G>A	c.(1588-1590)Ggt>Agt	p.G530S	PEG3_ENST00000593695.1_Missense_Mutation_p.G404S|PEG3_ENST00000598410.1_Missense_Mutation_p.G406S|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.G530S|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	530					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACAAGATAACCTCTAGCATGA	0.433000													21	125					0	0	0.654019	0	0
LCP2	3937	broad.mit.edu	37	5	169675786	169675786	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:169675786C>A	ENST00000046794.5	-	21	2132	c.1517G>T	c.(1516-1518)aGg>aTg	p.R506M	C5orf58_ENST00000517575.1_Intron|LCP2_ENST00000521416.1_Missense_Mutation_p.R301M	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	506	SH2.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		TGGCATTTTCCTGAAGTAGTC	0.433000													24	85					4.47668e-21	7.7759e-21	0.667858	1	0
ATP4A	495	broad.mit.edu	37	19	36046363	36046363	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:36046363G>A	ENST00000262623.3	-	14	2164	c.2136C>T	c.(2134-2136)atC>atT	p.I712I		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	712					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCTCTCCACGATCACCAGCT	0.672000													5	45					0	0	0.248553	0	0
ARHGAP6	395	broad.mit.edu	37	X	11157575	11157575	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:11157575G>T	ENST00000337414.4	-	13	3205	c.2333C>A	c.(2332-2334)cCa>cAa	p.P778Q	ARHGAP6_ENST00000380736.1_Missense_Mutation_p.P575Q|ARHGAP6_ENST00000303025.6_Missense_Mutation_p.P575Q|ARHGAP6_ENST00000534860.1_Intron	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	778					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGGCCAATTTGGGGACAGGTT	0.652000													3	19					0.150653	0.15318	0.150653	1	0
OR5L1	219437	broad.mit.edu	37	11	55579339	55579339	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:55579339A>G	ENST00000333973.2	+	1	486	c.397A>G	c.(397-399)Aca>Gca	p.T133A		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TTTGCTATACACAGTCACCAT	0.498000													29	92					0	0	0.740014	0	0
NBPF1	55672	broad.mit.edu	37	1	16893812	16893812	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:16893812C>A	ENST00000430580.2	-	25	3588	c.2701G>T	c.(2701-2703)Gaa>Taa	p.E901*	NBPF1_ENST00000432949.1_3'UTR|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	901	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGCAAGACTTCAGGCCCTTTC	0.478000													36	1375					1.55795e-14	2.38337e-14	0.608945	1	0
OSBPL5	114879	broad.mit.edu	37	11	3114185	3114185	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:3114185G>T	ENST00000263650.7	-	18	2203	c.2044C>A	c.(2044-2046)Cgt>Agt	p.R682S	OSBPL5_ENST00000525498.1_Missense_Mutation_p.R593S|OSBPL5_ENST00000542243.1_Missense_Mutation_p.R313S|OSBPL5_ENST00000478260.1_Missense_Mutation_p.R136S|OSBPL5_ENST00000389989.3_Missense_Mutation_p.R614S|OSBPL5_ENST00000348039.5_Missense_Mutation_p.R614S	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	682					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGCCGCTCACGGGCCCGCTGC	0.657000													3	10					0.000602214	0.000663929	0.184627	1	0
ANKRD44	91526	broad.mit.edu	37	2	197863714	197863714	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:197863714T>G	ENST00000328737.2	-	24	2583	c.2507A>C	c.(2506-2508)cAc>cCc	p.H836P	ANKRD44_ENST00000337207.5_Missense_Mutation_p.H836P|ANKRD44_ENST00000282272.8_Missense_Mutation_p.H853P|ANKRD44_ENST00000450567.1_Missense_Mutation_p.H836P			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	861							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGGAGCACTGTGTCTCAGAAG	0.463000													9	72					0	0	0.361761	0	0
OLA1	29789	broad.mit.edu	37	2	174943777	174943777	+	Silent	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:174943777T>G	ENST00000284719.3	-	10	1254	c.1008A>C	c.(1006-1008)acA>acC	p.T336T	OLA1_ENST00000428402.2_Intron|OLA1_ENST00000392560.2_5'UTR|OLA1_ENST00000409546.1_Silent_p.T356T|OLA1_ENST00000344357.5_Silent_p.T178T	NM_013341.3	NP_037473.3	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1	336					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						TTTCAAAATCTGTGTGAATCT	0.348000													8	13					0	0	0.307466	0	0
DLG2	1740	broad.mit.edu	37	11	84996390	84996390	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:84996390C>A	ENST00000376104.2	-	4	371	c.60G>T	c.(58-60)gaG>gaT	p.E20D	DLG2_ENST00000543673.1_Missense_Mutation_p.E20D	NM_001142699.1	NP_001136171.1	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	0						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GCAATGTCACCTCATAAAATT	0.348000													20	52					0.00188189	0.00202782	0.608945	1	0
FAT4	79633	broad.mit.edu	37	4	126389820	126389820	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:126389820A>G	ENST00000394329.3	+	11	12066	c.12053A>G	c.(12052-12054)cAg>cGg	p.Q4018R	FAT4_ENST00000335110.5_Missense_Mutation_p.Q2281R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4018	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TATGACAACCAGACAGGCGAC	0.398000													8	56					0	0	0.335167	0	0
HNRNPM	4670	broad.mit.edu	37	19	8548046	8548046	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:8548046C>G	ENST00000348943.3	+	14	1240	c.1008C>G	c.(1006-1008)atC>atG	p.I336M	HNRNPM_ENST00000325495.4_Missense_Mutation_p.I375M	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	375					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						CCTTAGAAATCCTAAGTAATG	0.363000													16	62					0	0	0.520397	0	0
LRRC10	376132	broad.mit.edu	37	12	70004149	70004149	+	Missense_Mutation	SNP	C	C	T	rs140782746	by1000genomes	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:70004149C>T	ENST00000361484.3	-	1	793	c.470G>A	c.(469-471)cGt>cAt	p.R157H		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	157						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TGGCAGCAAACGCAGGGCGTT	0.627000													4	39					0	0	0.150653	0	0
VNN2	8875	broad.mit.edu	37	6	133065622	133065622	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:133065622T>A	ENST00000326499.6	-	7	1504	c.1380A>T	c.(1378-1380)aaA>aaT	p.K460N	VNN2_ENST00000525270.1_Missense_Mutation_p.K407N|VNN2_ENST00000525289.1_Missense_Mutation_p.K239N	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	460					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		AACGCCCATCTTTCAGCACCT	0.383000													16	40					0	0	0.539581	0	0
IL2RA	3559	broad.mit.edu	37	10	6060060	6060060	+	Silent	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:6060060C>G	ENST00000379959.3	-	7	923	c.750G>C	c.(748-750)ctG>ctC	p.L250L	IL2RA_ENST00000379954.1_Silent_p.L178L|IL2RA_ENST00000256876.6_Silent_p.L241L	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	250					cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGACGCTGATCAGCAGGAAAA	0.612000													8	36					0	0	0.387290	0	0
ERN2	10595	broad.mit.edu	37	16	23706079	23706079	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:23706079C>T	ENST00000256797.4	-	17	2382	c.2214G>A	c.(2212-2214)gaG>gaA	p.E738E	ERN2_ENST00000457008.2_Silent_p.E638E	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	690	Protein kinase.			A -> V (in Ref. 1; BAB21297).	apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCTGCAGAAGCTCGGGCGCCA	0.637000													3	14					0	0	0.150653	0	0
ZNF761	388561	broad.mit.edu	37	19	53958032	53958032	+	RNA	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:53958032G>T	ENST00000454407.1	+	0	724							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		CCAGGATGTTGATAAAGATAT	0.383000													7	45					2.7689e-08	3.6284e-08	0.248553	1	0
MPO	4353	broad.mit.edu	37	17	56356753	56356753	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:56356753A>T	ENST00000340482.3	-	4	855	c.679T>A	c.(679-681)Ttt>Att	p.F227I	MPO_ENST00000225275.3_Missense_Mutation_p.F195I			P05164	PERM_HUMAN	myeloperoxidase	195					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CAGCGCACAAAGGCACGGTTG	0.701000													11	10					0	0	0.411799	0	0
DUSP9	1852	broad.mit.edu	37	X	152914746	152914746	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:152914746C>T	ENST00000342782.3	+	3	698	c.433C>T	c.(433-435)Cgt>Tgt	p.R145C	DUSP9_ENST00000370167.4_Missense_Mutation_p.R145C			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	145					inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTTGCTGGCCGTGCCGGCTC	0.682000													16	53					0	0	0.557998	0	0
FAM83B	222584	broad.mit.edu	37	6	54806078	54806078	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:54806078A>G	ENST00000306858.7	+	5	2425	c.2309A>G	c.(2308-2310)aAg>aGg	p.K770R		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	770										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTTTTGAAAAAGGGGTCTCAG	0.363000													3	25					0	0	0.115264	0	0
ZNF229	7772	broad.mit.edu	37	19	44934475	44934475	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:44934475G>C	ENST00000291187.4	-	6	785	c.463C>G	c.(463-465)Caa>Gaa	p.Q155E	ZNF229_ENST00000588931.1_Missense_Mutation_p.Q161E|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				CCATCCCCTTGTAGACTGTCC	0.478000													21	67					0	0	0.624587	0	0
DHX30	22907	broad.mit.edu	37	3	47868845	47868845	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:47868845G>T	ENST00000446256.2	+	6	588	c.16G>T	c.(16-18)Gac>Tac	p.D6Y	DHX30_ENST00000445061.1_Missense_Mutation_p.D45Y|DHX30_ENST00000457607.1_Missense_Mutation_p.D73Y|DHX30_ENST00000348968.4_Missense_Mutation_p.D17Y	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	45						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGCTTCTAGGGACCTATTAAA	0.423000													12	33					0.0167234	0.0173206	0.435327	1	0
ZNF233	353355	broad.mit.edu	37	19	44778041	44778041	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:44778041A>C	ENST00000391958.2	+	5	1355	c.1228A>C	c.(1228-1230)Aca>Cca	p.T410P	ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Missense_Mutation_p.T392P	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				CTTCAGTCAGACATCACAACT	0.413000													11	68					0	0	0.387290	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51649369	51649369	+	Missense_Mutation	SNP	G	G	A	rs140776910	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:51649369G>A	ENST00000317643.6	+	4	1087	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K	SIGLEC7_ENST00000305628.7_Missense_Mutation_p.E247K|SIGLEC7_ENST00000600577.1_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	340					cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CCTGCAACAGGAGTACACAGG	0.612000													17	83					0	0	0.592651	0	0
ST18	9705	broad.mit.edu	37	8	53045624	53045624	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:53045624C>A	ENST00000276480.7	-	21	3120	c.2437G>T	c.(2437-2439)Gaa>Taa	p.E813*		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	813						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TACTTCAGTTCAGGGTCTTCT	0.478000													24	62					4.87955e-14	7.36349e-14	0.693898	1	0
HAUS7	55559	broad.mit.edu	37	X	152721063	152721063	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:152721063A>T	ENST00000421080.2	-	10	1528	c.362T>A	c.(361-363)cTg>cAg	p.L121Q	HAUS7_ENST00000370212.3_Silent_p.P299P|TREX2_ENST00000334497.2_5'UTR|HAUS7_ENST00000484394.1_5'UTR|HAUS7_ENST00000370211.4_Silent_p.P289P|TREX2_ENST00000338525.2_5'UTR|TREX2_ENST00000370232.1_5'UTR|TREX2_ENST00000330912.2_5'UTR|HAUS7_ENST00000370219.3_Silent_p.P299P			Q99871	HAUS7_HUMAN	HAUS augmin-like complex, subunit 7	260					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding			endometrium(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)	19						GGTGGAGGTCAGGGCCTGGGC	0.617000													19	35					0	0	0.592651	0	0
MYH2	4620	broad.mit.edu	37	17	10439908	10439908	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:10439908C>G	ENST00000245503.5	-	17	2297	c.1913G>C	c.(1912-1914)gGg>gCg	p.G638A	MYH2_ENST00000532183.1_Missense_Mutation_p.G638A|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.G638A|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	638	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTTCTTGGCCCCTCCACCAGC	0.418000													5	26					0	0	0.248553	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812738	31812738	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:31812738C>T	ENST00000334067.3	+	1	142	c.93C>T	c.(91-93)ccC>ccT	p.P31P		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	31						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						TGTTCTACCCCAGCAATGCCA	0.478000													7	41					0	0	0.248553	0	0
DQX1	165545	broad.mit.edu	37	2	74752246	74752246	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:74752246T>A	ENST00000404568.3	-	3	540	c.321A>T	c.(319-321)gcA>gcT	p.A107A	DQX1_ENST00000393951.2_Silent_p.A107A	NM_133637.2	NP_598376.2	Q8TE96	DQX1_HUMAN	DEAQ box RNA-dependent ATPase 1	107	Helicase ATP-binding.					nucleus	ATP binding|helicase activity|nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	18						GGCTCCGGGCTGCAAGAGGGT	0.592000													15	25					0	0	0.457914	0	0
MLLT4	4301	broad.mit.edu	37	6	168312131	168312131	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:168312131G>A	ENST00000366806.2	+	15	2141	c.1999G>A	c.(1999-2001)Gtc>Atc	p.V667I	MLLT4_ENST00000392112.1_Missense_Mutation_p.V651I|MLLT4_ENST00000400822.3_Missense_Mutation_p.V666I|MLLT4_ENST00000351017.4_Missense_Mutation_p.V667I|MLLT4_ENST00000447894.2_Missense_Mutation_p.V667I|MLLT4_ENST00000344191.4_Missense_Mutation_p.V667I|MLLT4_ENST00000392108.3_Missense_Mutation_p.V667I			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	667					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CATTGCAGTCGTCAACAAGAT	0.493000			T	MLL	AL								3	48					0	0	0.115264	0	0
BRINP2	57795	broad.mit.edu	37	1	177250061	177250061	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:177250061G>T	ENST00000361539.4	+	8	2061	c.1749G>T	c.(1747-1749)gaG>gaT	p.E583D	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		583						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GCACCCTGGAGCCTGTCATGG	0.557000													16	16					9.16793e-09	1.21813e-08	0.520397	1	0
KIAA1009	22832	broad.mit.edu	37	6	84904721	84904721	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:84904721A>T	ENST00000403245.3	-	10	1022	c.908T>A	c.(907-909)tTg>tAg	p.L303*	KIAA1009_ENST00000461137.1_5'UTR|KIAA1009_ENST00000257766.4_Nonsense_Mutation_p.L227*	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	303					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TTCATCTCCCAATGAATGGGC	0.368000													3	9					0	0	0.115264	0	0
ABCC11	85320	broad.mit.edu	37	16	48256673	48256673	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:48256673G>T	ENST00000394747.1	-	5	962	c.613C>A	c.(613-615)Ctc>Atc	p.L205I	ABCC11_ENST00000353782.5_Missense_Mutation_p.L205I|ABCC11_ENST00000394748.1_Missense_Mutation_p.L205I|ABCC11_ENST00000537808.1_Missense_Mutation_p.L205I|ABCC11_ENST00000356608.2_Missense_Mutation_p.L205I	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	205	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCAAAGCAGAGTCCCACTCCA	0.458000													14	41					3.32936e-07	4.16638e-07	0.539581	1	0
CYP27C1	339761	broad.mit.edu	37	2	127944892	127944892	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:127944892C>T	ENST00000335247.7	-	8	1204	c.1074G>A	c.(1072-1074)ctG>ctA	p.L358L	CYP27C1_ENST00000409327.1_Silent_p.L358L	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	358						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		CCCCTGGCGTCAGGAGCCCGT	0.488000													30	47					0	0	0.750413	0	0
HK1	3098	broad.mit.edu	37	10	71078721	71078721	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:71078721C>T	ENST00000359426.6	+	1	122	c.18C>T	c.(16-18)ctC>ctT	p.L6L	HK1_ENST00000298649.3_Intron|HK1_ENST00000360289.2_Intron|HK1_ENST00000448642.2_Intron|HK1_ENST00000404387.2_Intron	NM_000188.2	NP_000179.2	P19367	HXK1_HUMAN	hexokinase 1	6	Hydrophobic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						CCGCGCAGCTCCTGGCCTATT	0.716000													4	14					0	0	0.150653	0	0
CCAR1	55749	broad.mit.edu	37	10	70514515	70514515	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:70514515G>T	ENST00000265872.6	+	12	1508	c.1389G>T	c.(1387-1389)aaG>aaT	p.K463N	CCAR1_ENST00000543719.1_Missense_Mutation_p.K448N|CCAR1_ENST00000535016.1_Missense_Mutation_p.K448N	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	463					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TATATCATAAGTCATGTGCTC	0.353000													28	78					4.10981e-09	5.50451e-09	0.812448	1	0
DHTKD1	55526	broad.mit.edu	37	10	12136082	12136082	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:12136082G>T	ENST00000263035.4	+	7	1232	c.1170G>T	c.(1168-1170)gtG>gtT	p.V390V	DHTKD1_ENST00000465617.1_3'UTR	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	390					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GGAAGCTTGTGGGCTGTGCCA	0.527000													31	105					2.58029e-29	4.66409e-29	0.847076	1	0
LINC00933	100506874	broad.mit.edu	37	15	85121395	85121395	+	RNA	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:85121395G>T	ENST00000557887.1	+	0	595					NR_038273.1|NR_038274.1																						TGGTGACAATGTAAGTTGTTA	0.433000													9	40					1.08611e-07	1.39047e-07	0.387290	1	0
SH3GL2	6456	broad.mit.edu	37	9	17793473	17793473	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:17793473C>T	ENST00000380607.4	+	8	957	c.837C>T	c.(835-837)caC>caT	p.H279H	SH3GL2_ENST00000537391.1_Silent_p.H232H	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	279					axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GTCTCTCCCACACAGGCACTC	0.483000													5	52					0	0	0.184627	0	0
SP6	80320	broad.mit.edu	37	17	45925440	45925440	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:45925440G>T	ENST00000536300.1	-	2	687	c.356C>A	c.(355-357)tCg>tAg	p.S119*	SP6_ENST00000342234.2_Nonsense_Mutation_p.S119*	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						GTCCCACCACGAGCCATCCTC	0.672000													13	21					1.15088e-07	1.46775e-07	0.500413	1	0
ATP2A3	489	broad.mit.edu	37	17	3853845	3853845	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:3853845G>T	ENST00000309890.7	-	7	740	c.590C>A	c.(589-591)cCc>cAc	p.P197H	ATP2A3_ENST00000397041.3_Missense_Mutation_p.P197H|ATP2A3_ENST00000397035.3_Missense_Mutation_p.P197H|ATP2A3_ENST00000397043.3_Missense_Mutation_p.P197H|ATP2A3_ENST00000352011.3_Missense_Mutation_p.P197H|ATP2A3_ENST00000359983.3_Missense_Mutation_p.P197H|ATP2A3_ENST00000397039.1_5'UTR	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	197					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding	p.P197R(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CACAGCTCTGGGGTCTGGGAT	0.483000													25	61					2.08457e-15	3.30263e-15	0.750413	1	0
MT3	4504	broad.mit.edu	37	16	56623854	56623854	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:56623854G>T	ENST00000570176.1	+	2	155	c.104G>T	c.(103-105)tGc>tTc	p.C35F	MT3_ENST00000200691.4_Intron|MT3_ENST00000566576.1_Intron|MT3_ENST00000565838.1_Intron|MT3_ENST00000561640.1_Intron			P25713	MT3_HUMAN	metallothionein 3	35	Alpha.				cell proliferation|cellular metal ion homeostasis|removal of superoxide radicals|response to hypoxia	synaptic vesicle	antioxidant activity|copper ion binding|zinc ion binding			central_nervous_system(1)|large_intestine(1)	2						AAGAGTGAGTGCGGGGACCCT	0.652000													5	48					1.23904e-05	1.4423e-05	0.184627	1	0
CCDC74B	91409	broad.mit.edu	37	2	130900785	130900785	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:130900785G>A	ENST00000409234.3	-	2	438	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F	CCDC74B_ENST00000310463.6_Intron|CCDC74B_ENST00000409128.1_Intron|CCDC74B_ENST00000392984.3_5'UTR|CCDC74B_ENST00000409943.3_Intron			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	262										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					ACAGTCTGGAGGGGCTCCCCT	0.582000													4	32					0	0	0.217242	0	0
TRO	7216	broad.mit.edu	37	X	54950927	54950927	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:54950927G>T	ENST00000173898.7	+	4	1392	c.1280G>T	c.(1279-1281)aGg>aTg	p.R427M	TRO_ENST00000375041.2_Missense_Mutation_p.R30M|TRO_ENST00000484031.1_3'UTR|TRO_ENST00000399736.1_Missense_Mutation_p.R30M|TRO_ENST00000375022.4_Missense_Mutation_p.R427M|TRO_ENST00000420798.2_5'UTR|TRO_ENST00000319167.8_Missense_Mutation_p.R427M	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	427					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						AGTAATTACAGGCGGATCCCA	0.507000													9	14					4.36969e-10	5.99709e-10	0.435327	1	0
SYCP2	10388	broad.mit.edu	37	20	58441592	58441592	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:58441592T>A	ENST00000357552.3	-	40	4403	c.4178A>T	c.(4177-4179)cAg>cTg	p.Q1393L	SYCP2_ENST00000371001.2_Missense_Mutation_p.Q1393L			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1393					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			CAGATGTTGCTGAGCTGTTTT	0.303000													21	30					0	0	0.706142	0	0
LAMB1	3912	broad.mit.edu	37	7	107602048	107602048	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:107602048C>G	ENST00000393561.1	-	14	2187	c.2003G>C	c.(2002-2004)gGt>gCt	p.G668A	LAMB1_ENST00000222399.6_Missense_Mutation_p.G644A|LAMB1_ENST00000393560.1_Missense_Mutation_p.G644A			P07942	LAMB1_HUMAN	laminin, beta 1	644	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATGGTATTACCACATCGGCT	0.493000													16	143					0	0	0.520397	0	0
SAGE1	55511	broad.mit.edu	37	X	134990304	134990304	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:134990304C>T	ENST00000535938.1	+	11	1383	c.1216C>T	c.(1216-1218)Cct>Tct	p.P406S	SAGE1_ENST00000324447.3_Missense_Mutation_p.P406S|SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000370709.3_Missense_Mutation_p.P406S	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	406										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					CCAACCAACCCCTGATAACGT	0.443000													49	139					0	0	0.870114	0	0
DHTKD1	55526	broad.mit.edu	37	10	12136083	12136083	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:12136083G>T	ENST00000263035.4	+	7	1233	c.1171G>T	c.(1171-1173)Ggc>Tgc	p.G391C	DHTKD1_ENST00000465617.1_3'UTR	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	391					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GAAGCTTGTGGGCTGTGCCAT	0.522000													31	104					2.58029e-29	4.66409e-29	0.847076	1	0
MUC16	94025	broad.mit.edu	37	19	9071390	9071390	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:9071390G>T	ENST00000397910.4	-	3	16259	c.16056C>A	c.(16054-16056)tcC>tcA	p.S5352S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5354	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGTGATGTGGAGGAAACAG	0.527000													14	60					0.00074312	0.000813894	0.539581	1	0
OAS2	4939	broad.mit.edu	37	12	113444257	113444257	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:113444257A>G	ENST00000392583.2	+	8	1715	c.1508A>G	c.(1507-1509)tAt>tGt	p.Y503C	OAS2_ENST00000342315.4_Missense_Mutation_p.Y503C|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	503	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CCCGAGGTTTATGCAGGGCTC	0.507000													27	35					0	0	0.729181	0	0
TTF2	8458	broad.mit.edu	37	1	117616346	117616346	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:117616346G>T	ENST00000369466.3	+	4	326	c.282G>T	c.(280-282)tgG>tgT	p.W94C		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II	94					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GTATTCCATGGCAGGTAGGAA	0.378000													5	58					8.12818e-05	9.29931e-05	0.248553	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83403092	83403092	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:83403092G>T	ENST00000262752.2	-	4	305	c.298C>A	c.(298-300)Cag>Aag	p.Q100K	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.Q100K	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	100	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GCATAGAGCTGCCCAGCATCA	0.294000													7	41					3.86212e-05	4.45681e-05	0.361761	1	0
GPR63	81491	broad.mit.edu	37	6	97247421	97247421	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:97247421T>A	ENST00000229955.3	-	2	532	c.187A>T	c.(187-189)Agt>Tgt	p.S63C	GPR63_ENST00000417980.1_Missense_Mutation_p.S63C	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	63						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		ACAGCTGTACTATTCACGGTC	0.443000													17	48					0	0	0.575678	0	0
AKNA	80709	broad.mit.edu	37	9	117124156	117124156	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:117124156C>A	ENST00000307564.4	-	9	2113	c.1952G>T	c.(1951-1953)tGc>tTc	p.C651F	AKNA_ENST00000374075.5_Missense_Mutation_p.C570F|AKNA_ENST00000374088.3_Missense_Mutation_p.C651F|AKNA_ENST00000312033.3_Missense_Mutation_p.C651F|AKNA_ENST00000223791.3_Missense_Mutation_p.C111F	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CTCTTCCAGGCAGCTTCCCAG	0.597000													6	38					3.59834e-05	4.1596e-05	0.217242	1	0
ATP8A2	51761	broad.mit.edu	37	13	26535748	26535748	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:26535748G>A	ENST00000381655.2	+	34	3361	c.3219G>A	c.(3217-3219)ttG>ttA	p.L1073L	ATP8A2_ENST00000255283.8_Silent_p.L1008L	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	1033					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACTTCTGGTTGGGATTATTTC	0.448000													28	95					0	0	0.779181	0	0
TTC7A	57217	broad.mit.edu	37	2	47300960	47300960	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:47300960C>A	ENST00000319190.5	+	20	2843	c.2475C>A	c.(2473-2475)gcC>gcA	p.A825A	CALM2_ENST00000422269.1_Intron|TTC7A_ENST00000409245.1_Silent_p.A791A|TTC7A_ENST00000394850.2_Silent_p.A849A|TTC7A_ENST00000263737.6_Silent_p.A471A	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	825							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGCTGCAGGCCCAGGGCCAGA	0.652000													18	37					1.33834e-09	1.81069e-09	0.557998	1	0
EPPK1	83481	broad.mit.edu	37	8	144943141	144943141	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:144943141G>T	ENST00000525985.1	-	2	4352	c.4281C>A	c.(4279-4281)acC>acA	p.T1427T				P58107	EPIPL_HUMAN	epiplakin 1	1427						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAACAATCCGGTCTCGGAGT	0.612000													9	73					1.76689e-08	2.31992e-08	0.335167	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227216678	227216678	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:227216678C>A	ENST00000366769.3	-	29	5298	c.4007G>T	c.(4006-4008)cGt>cTt	p.R1336L	CDC42BPA_ENST00000366766.2_Missense_Mutation_p.R1371L|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.R1316L|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.R1308L|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.R1336L|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.R1255L|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.R1349L	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1349	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				TTTTCTGTGACGGGTCTTGCT	0.443000													8	59					5.18039e-06	6.14826e-06	0.278610	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212776	26212776	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:26212776C>A	ENST00000379034.1	+	2	962	c.813C>A	c.(811-813)ccC>ccA	p.P271P		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	271	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TAGGCCTCCCCAGTGAAGGAA	0.527000													51	117					1.27862e-28	2.30497e-28	0.870114	1	0
FLG	2312	broad.mit.edu	37	1	152284251	152284251	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:152284251G>T	ENST00000368799.1	-	3	3146	c.3111C>A	c.(3109-3111)caC>caA	p.H1037Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1037	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGACTGCTGGTGGCGGGATC	0.567000									Ichthyosis				309	453					1.11737e-147	2.14163e-147	0.870114	1	0
H3F3B	3021	broad.mit.edu	37	17	73775159	73775159	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:73775159T>A	ENST00000254810.4	-	2	229	c.97A>T	c.(97-99)Acc>Tcc	p.T33S	H3F3B_ENST00000592643.1_Missense_Mutation_p.T33S|H3F3B_ENST00000591890.1_Missense_Mutation_p.T33S|H3F3B_ENST00000587560.1_Missense_Mutation_p.T33S|H3F3B_ENST00000593254.1_Intron|H3F3B_ENST00000586607.1_Missense_Mutation_p.T33S|H3F3B_ENST00000589599.1_Missense_Mutation_p.T33S	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	33					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACCCCGCCGGTAGAGGGAGCG	0.652000											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	28					0	0	0.115264	0	0
GLRA2	2742	broad.mit.edu	37	X	14627160	14627160	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:14627160G>T	ENST00000218075.4	+	7	1293	c.763G>T	c.(763-765)Gga>Tga	p.G255*	GLRA2_ENST00000443437.2_Nonsense_Mutation_p.G166*|GLRA2_ENST00000355020.4_Nonsense_Mutation_p.G255*	NM_002063.3	NP_002054.1	P23416	GLRA2_HUMAN	glycine receptor, alpha 2	255					neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(22)|ovary(1)|prostate(1)|skin(2)	37	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	ACGCCAAATGGGATATTATTT	0.408000													15	170					7.45023e-12	1.07328e-11	0.592651	1	0
RYR2	6262	broad.mit.edu	37	1	237893592	237893592	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:237893592A>G	ENST00000366574.2	+	77	11188	c.10871A>G	c.(10870-10872)tAt>tGt	p.Y3624C	RYR2_ENST00000360064.6_Missense_Mutation_p.Y3622C|RYR2_ENST00000542537.1_Missense_Mutation_p.Y3608C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3624					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTCAGGGATATGAAAAGTCT	0.358000													18	20					0	0	0.654019	0	0
PLXNA3	55558	broad.mit.edu	37	X	153692504	153692504	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153692504C>A	ENST00000369682.3	+	8	1851	c.1676C>A	c.(1675-1677)aCc>aAc	p.T559N		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	559					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCCAGCTGACCGTCACCCTG	0.697000													6	37					3.59834e-05	4.1596e-05	0.217242	1	0
F13A1	2162	broad.mit.edu	37	6	6222322	6222322	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:6222322G>T	ENST00000264870.3	-	8	1321	c.1056C>A	c.(1054-1056)gaC>gaA	p.D352E		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	352					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCAGGAAGATGTCCATTTGCA	0.408000													13	52					1.45105e-14	2.23007e-14	0.539581	1	0
AKAP11	11215	broad.mit.edu	37	13	42871266	42871266	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:42871266G>C	ENST00000025301.2	+	6	474	c.299G>C	c.(298-300)tGt>tCt	p.C100S		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	100					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GAAATTATTTGTATGAAGAAT	0.284000													21	46					0	0	0.608945	0	0
AIFM1	9131	broad.mit.edu	37	X	129271160	129271160	+	Splice_Site	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:129271160G>T	ENST00000287295.3	-	10	1198	c.967_splice	c.e10-1	p.A323_splice	AIFM1_ENST00000346424.2_Splice_Site_p.A36_splice|AIFM1_ENST00000440263.1_5'UTR|AIFM1_ENST00000319908.3_Splice_Site_p.A319_splice|AIFM1_ENST00000460436.2_5'UTR|AIFM1_ENST00000535724.1_3'UTR	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	323	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						CAAGGCTCGAGCTGGGAAGAA	0.483000													28	80					1.39806e-14	2.15857e-14	0.729181	1	0
MXRA5	25878	broad.mit.edu	37	X	3238377	3238377	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:3238377G>T	ENST00000217939.6	-	5	5503	c.5349C>A	c.(5347-5349)ggC>ggA	p.G1783G		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1783						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGCCGGAGGGCCAAAGTCCA	0.498000													15	34					4.96729e-08	6.44588e-08	0.575678	1	0
ZNF547	284306	broad.mit.edu	37	19	57888711	57888711	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:57888711C>T	ENST00000282282.3	+	4	517	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACATCTTCACCAGCACCAAAA	0.507000													22	96					0	0	0.706142	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590557	140590557	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140590557C>G	ENST00000239450.2	+	1	2267	c.2078C>G	c.(2077-2079)gCg>gGg	p.A693G	PCDHB12_ENST00000541609.1_Missense_Mutation_p.A356G	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		693					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.A693V(1)		NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGTGGTGGCGTTGGCCTCA	0.706000													18	162					0	0	0.575678	0	0
PRKD1	5587	broad.mit.edu	37	14	30066937	30066937	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:30066937G>A	ENST00000331968.5	-	16	2423	c.2194C>T	c.(2194-2196)Cgg>Tgg	p.R732W	PRKD1_ENST00000415220.2_Missense_Mutation_p.R740W	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	732	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CCAATGATCCGGGCAAAACCA	0.473000													7	49					0	0	0.435327	0	0
PDGFRA	5156	broad.mit.edu	37	4	55152085	55152085	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:55152085G>T	ENST00000257290.5	+	18	2848	c.2517G>T	c.(2515-2517)ctG>ctT	p.L839L	FIP1L1_ENST00000507166.1_Silent_p.L599L	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	839	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.L839L(1)		NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ACTTTGGCCTGGCCAGAGACA	0.488000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			36	164					1.22674e-20	2.09805e-20	0.840704	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130343219	130343219	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:130343219G>T	ENST00000299164.2	+	8	2356	c.2356G>T	c.(2356-2358)Gtg>Ttg	p.V786L		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	786	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GGTCCTCTCCGTGGGGAAGAT	0.672000													29	105					1.99505e-19	3.35189e-19	0.760397	1	0
FZD10	11211	broad.mit.edu	37	12	130648515	130648515	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:130648515G>A	ENST00000229030.4	+	1	1512	c.1028G>A	c.(1027-1029)gGc>gAc	p.G343D	FZD10_ENST00000539839.1_Silent_p.G310G			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	343					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AAGAAGTGGGGCCACGAGGCC	0.647000													4	43					0	0	0.150653	0	0
RBMS3	27303	broad.mit.edu	37	3	29628605	29628605	+	Splice_Site	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:29628605G>T	ENST00000434693.2	+	4	1005	c.304_splice	c.e4-1	p.G102_splice	RBMS3_ENST00000456853.1_Splice_Site_p.G103_splice|RBMS3_ENST00000452462.1_Splice_Site_p.G103_splice|RBMS3_ENST00000383767.2_Splice_Site_p.G103_splice|RBMS3_ENST00000383766.2_Splice_Site_p.G102_splice|RBMS3_ENST00000445033.1_Splice_Site_p.G103_splice|RBMS3_ENST00000273139.9_Splice_Site_p.G103_splice|RBMS3_ENST00000396583.3_Splice_Site_p.G103_splice	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	103	RRM 1.					cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				GTTTTCACAGGTTATGGTTTT	0.408000													13	31					7.93312e-07	9.74474e-07	0.457914	1	0
PCDHA1	56147	broad.mit.edu	37	5	140167630	140167630	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140167630G>T	ENST00000504120.2	+	1	1755	c.1755G>T	c.(1753-1755)gtG>gtT	p.V585V	PCDHA1_ENST00000378133.3_Silent_p.V585V|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGATTGGTGGGTGCGGGTC	0.672000													11	100					1.05317e-09	1.43068e-09	0.457914	1	0
FAT4	79633	broad.mit.edu	37	4	126373905	126373905	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:126373905G>T	ENST00000394329.3	+	9	11747	c.11734G>T	c.(11734-11736)Ggt>Tgt	p.G3912C	FAT4_ENST00000335110.5_Missense_Mutation_p.G2210C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3912	EGF-like 3; calcium-binding (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTGCAAGAATGGTGCCATCTG	0.458000													6	60					2.0095e-06	2.42375e-06	0.248553	1	0
KCNU1	157855	broad.mit.edu	37	8	36766951	36766951	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:36766951T>A	ENST00000399881.3	+	21	2266	c.2229T>A	c.(2227-2229)taT>taA	p.Y743*		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	743						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCAGCAACTATACCAGGAAGG	0.463000													19	189					0	0	0.592651	0	0
VMP1	81671	broad.mit.edu	37	17	57842339	57842339	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:57842339A>T	ENST00000262291.4	+	6	732	c.422A>T	c.(421-423)cAt>cTt	p.H141L	VMP1_ENST00000536180.1_Missense_Mutation_p.H44L|VMP1_ENST00000537567.1_Missense_Mutation_p.H7L|VMP1_ENST00000539763.1_5'UTR|VMP1_ENST00000545362.1_Intron	NM_030938.3	NP_112200.2	Q96GC9	VMP1_HUMAN	vacuole membrane protein 1	141					autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|skin(2)	16						TAGGGTCCACATATAGCCTCA	0.303000													7	89					0	0	0.248553	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103062245	103062245	+	Splice_Site	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:103062245G>A	ENST00000375735.2	+	46	7581		c.e46-1		DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Splice_Site	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTCTTTTTCAGGTGCGAGCCA	0.313000													4	5					0	0	0.150653	0	0
ZEB2	9839	broad.mit.edu	37	2	145156879	145156879	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:145156879G>T	ENST00000558170.2	-	8	3059	c.1875C>A	c.(1873-1875)gcC>gcA	p.A625A	ZEB2_ENST00000409487.3_Silent_p.A625A|ZEB2_ENST00000303660.4_Silent_p.A625A|ZEB2_ENST00000539609.3_Silent_p.A601A	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	625						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CAAAAACTCCGGCTTTGTTGG	0.458000													13	22					1.5842e-08	2.08826e-08	0.435327	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803130	185803130	+	Missense_Mutation	SNP	C	C	A	rs138725858		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:185803130C>A	ENST00000302277.6	+	4	3601	c.3007C>A	c.(3007-3009)Cca>Aca	p.P1003T		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1003						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TAACACACAACCACCATTACC	0.428000													13	103					0.00316338	0.00338137	0.479597	1	0
FBXO7	25793	broad.mit.edu	37	22	32875128	32875128	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:32875128C>T	ENST00000266087.7	+	2	610	c.283C>T	c.(283-285)Cat>Tat	p.H95Y	FBXO7_ENST00000465418.1_3'UTR|FBXO7_ENST00000382058.3_Missense_Mutation_p.H16Y|FBXO7_ENST00000397426.1_5'UTR	NM_012179.3	NP_036311.3	Q9Y3I1	FBX7_HUMAN	F-box protein 7	95					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGATTCAGAGCATTCTTCACT	0.448000													21	132					0	0	0.575678	0	0
MST1R	4486	broad.mit.edu	37	3	49933714	49933714	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:49933714G>A	ENST00000296474.3	-	10	2590	c.2563C>T	c.(2563-2565)Cct>Tct	p.P855S	MST1R_ENST00000344206.4_Missense_Mutation_p.P855S	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	855	IPT/TIG 3.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CGAAAGCCAGGCAGTGTAAAG	0.582000													37	139					0	0	0.859065	0	0
SLK	9748	broad.mit.edu	37	10	105762387	105762387	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:105762387A>T	ENST00000369755.3	+	9	1996	c.1451A>T	c.(1450-1452)aAg>aTg	p.K484M	SLK_ENST00000335753.4_Missense_Mutation_p.K484M	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	484	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTTGAAAATAAGCTTATAAAA	0.284000													5	15					0	0	0.217242	0	0
DMD	1756	broad.mit.edu	37	X	32328357	32328357	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:32328357C>G	ENST00000357033.4	-	42	6165	c.5959G>C	c.(5959-5961)Gaa>Caa	p.E1987Q	DMD_ENST00000378677.2_Missense_Mutation_p.E1983Q	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1987					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCATGTCTTCAGTCATCACC	0.378000													16	37					0	0	0.557998	0	0
ITGAL	3683	broad.mit.edu	37	16	30500470	30500470	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:30500470C>T	ENST00000356798.6	+	10	1254	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Silent_p.L275L|ITGAL_ENST00000568012.1_3'UTR|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	358					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GTGCTGACCTCAGCAGGGTGC	0.612000													12	102					0	0	0.457914	0	0
KCNK3	3777	broad.mit.edu	37	2	26951265	26951265	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:26951265G>T	ENST00000302909.3	+	2	1139	c.1014G>T	c.(1012-1014)acG>acT	p.T338T		NM_002246.2	NP_002237.1	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	338					synaptic transmission	integral to plasma membrane				endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTCCGACACGTGCGTGGAGC	0.677000													5	7					8.12818e-05	9.29931e-05	0.248553	1	0
NGEF	25791	broad.mit.edu	37	2	233785021	233785021	+	Silent	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:233785021T>C	ENST00000264051.3	-	5	1079	c.801A>G	c.(799-801)ctA>ctG	p.L267L	NGEF_ENST00000409079.1_Silent_p.L175L|NGEF_ENST00000373552.4_Silent_p.L175L	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	267	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		CCTCGGGCTGTAGGATCTCAA	0.642000													19	89					0	0	0.608945	0	0
USP31	57478	broad.mit.edu	37	16	23079849	23079849	+	Missense_Mutation	SNP	C	C	A	rs146941953	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:23079849C>A	ENST00000219689.7	-	16	3576	c.3577G>T	c.(3577-3579)Ggg>Tgg	p.G1193W	USP31_ENST00000567975.1_Missense_Mutation_p.G486W	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1193	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		ACGTGCTTCCCGGCCCCCCTG	0.642000													27	82					6.38683e-12	9.22081e-12	0.729181	1	0
SMARCA1	6594	broad.mit.edu	37	X	128640126	128640126	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:128640126C>T	ENST00000371122.4	-	8	1158	c.1029G>A	c.(1027-1029)ttG>ttA	p.L343L	SMARCA1_ENST00000371121.3_Silent_p.L343L|SMARCA1_ENST00000371123.1_Silent_p.L343L	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	343	Helicase ATP-binding.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						GGTTATTCTGCAAAGGTGTTC	0.363000													86	226					0	0	0.870114	0	0
C21orf33	8209	broad.mit.edu	37	21	45563123	45563123	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:45563123G>C	ENST00000291577.6	+	6	651	c.558G>C	c.(556-558)gtG>gtC	p.V186V	C21orf33_ENST00000348499.5_Silent_p.V155V	NM_004649.6	NP_004640.3	P30042	ES1_HUMAN	chromosome 21 open reading frame 33	186						mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		CGGCCAAGGTGCTCAGAGGCG	0.617000													7	43					0	0	0.278610	0	0
MDGA2	161357	broad.mit.edu	37	14	47389256	47389256	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:47389256C>T	ENST00000426342.1	-	10	2049	c.1303G>A	c.(1303-1305)Gca>Aca	p.A435T	MDGA2_ENST00000399232.2_Missense_Mutation_p.A733T|MDGA2_ENST00000439988.2_Missense_Mutation_p.A664T|MDGA2_ENST00000357362.3_Missense_Mutation_p.A435T	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	664	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CGATCCACTGCATCAGGATTC	0.433000													15	56					0	0	0.539581	0	0
USP31	57478	broad.mit.edu	37	16	23080836	23080836	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:23080836T>A	ENST00000219689.7	-	16	2589	c.2590A>T	c.(2590-2592)Aga>Tga	p.R864*	USP31_ENST00000567975.1_Nonsense_Mutation_p.R157*	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	864	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		CATGAAGGTCTCATGCAATTT	0.502000													7	33					0	0	0.307466	0	0
DACT1	51339	broad.mit.edu	37	14	59108400	59108400	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:59108400G>T	ENST00000395153.3	+	3	716	c.569G>T	c.(568-570)aGc>aTc	p.S190I	DACT1_ENST00000395151.3_Intron|DACT1_ENST00000541264.2_5'UTR|DACT1_ENST00000555845.1_3'UTR|DACT1_ENST00000556859.1_5'UTR|DACT1_ENST00000335867.4_Missense_Mutation_p.S190I	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	190					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						TGTCATTCCAGCACCTGCTTT	0.438000													22	103					6.32553e-13	9.37584e-13	0.681144	1	0
AMOTL1	154810	broad.mit.edu	37	11	94554829	94554829	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:94554829C>A	ENST00000433060.2	+	4	1396	c.1255C>A	c.(1255-1257)Cag>Aag	p.Q419K	AMOTL1_ENST00000317829.8_Missense_Mutation_p.Q369K|AMOTL1_ENST00000539727.1_3'UTR|AMOTL1_ENST00000317837.9_Intron	NM_130847.2	NP_570899.1	Q8IY63	AMOL1_HUMAN	angiomotin like 1	419						cytoplasm|tight junction	identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	36		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				GGGTGCTCCACAGCCCCCGCC	0.642000													6	42					0.217242	0.219546	0.217242	1	0
DACH1	1602	broad.mit.edu	37	13	72063271	72063271	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:72063271G>A	ENST00000305425.4	-	7	2008	c.1586C>T	c.(1585-1587)cCg>cTg	p.P529L	DACH1_ENST00000359684.2_Missense_Mutation_p.P581L|DACH1_ENST00000313174.7_Missense_Mutation_p.P381L|DACH1_ENST00000354591.4_Missense_Mutation_p.P327L	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	579					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGTAGAAAGCGGGGTCTCATC	0.443000													62	158					0	0	0.870114	0	0
SLC6A18	348932	broad.mit.edu	37	5	1244466	1244466	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:1244466G>A	ENST00000324642.3	+	10	1597	c.1474G>A	c.(1474-1476)Gtt>Att	p.V492I	SLC6A18_ENST00000296821.4_Missense_Mutation_p.V390I	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	492					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGTGGGTGTCGTTTATGTTTA	0.572000													10	129					0	0	0.387290	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146825825	146825825	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:146825825C>A	ENST00000361727.3	+	7	1496	c.980C>A	c.(979-981)tCc>tAc	p.S327Y		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	327	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAGCCCAGCTCCAGCAGTAGA	0.393000										HNSCC(39;0.1)			34	77					7.53189e-24	1.33611e-23	0.834066	1	0
SEPT6	23157	broad.mit.edu	37	X	118797602	118797602	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:118797602G>A	ENST00000394610.1	-	3	448	c.184C>T	c.(184-186)Ctg>Ttg	p.L62L	SEPT6_ENST00000360156.7_Silent_p.L62L|SEPT6_ENST00000354416.3_Silent_p.L62L|SEPT6_ENST00000343984.5_Silent_p.L62L|SEPT6_ENST00000354228.4_Silent_p.L62L|SEPT6_ENST00000489216.1_Silent_p.L62L|SEPT6_ENST00000394617.2_Silent_p.L92L|SEPT6_ENST00000394616.4_Silent_p.L4L	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	62					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						GTGTTGAACAGGGTGTCCATG	0.502000			T	MLL	AML								58	454					0	0	0.870114	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411992	23411992	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:23411992G>T	ENST00000379361.4	+	3	3217	c.2357G>T	c.(2356-2358)tGg>tTg	p.W786L		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	786					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						AGAACTAAATGGGTAAAAAAT	0.388000													34	67					9.62906e-15	1.49711e-14	0.819951	1	0
PECR	55825	broad.mit.edu	37	2	216930034	216930034	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:216930034C>A	ENST00000265322.7	-	3	499		c.e3+1		PECR_ENST00000497889.1_Splice_Site	NM_018441.5	NP_060911.2	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase						fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity			endometrium(2)|kidney(1)|liver(1)|lung(9)|stomach(1)	14		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	ATGGTACTTGCCTGCTTTGCA	0.463000													14	110					0.00074312	0.000813894	0.539581	1	0
TEP1	7011	broad.mit.edu	37	14	20876563	20876563	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:20876563T>A	ENST00000262715.5	-	2	76	c.36A>T	c.(34-36)ccA>ccT	p.P12P	TEP1_ENST00000556935.1_Silent_p.P12P	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	12					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGAGGATGTCTGGATGGGCAG	0.507000													25	72					0	0	0.750413	0	0
MAP4K1	11184	broad.mit.edu	37	19	39096339	39096339	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:39096339G>T	ENST00000591517.1	-	18	1260	c.1232C>A	c.(1231-1233)cCt>cAt	p.P411H	MAP4K1_ENST00000396857.2_Missense_Mutation_p.P411H|MAP4K1_ENST00000586296.1_Intron|MAP4K1_ENST00000423454.2_Missense_Mutation_p.P73H|MAP4K1_ENST00000589130.1_Missense_Mutation_p.P407H	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	411					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CATGCTCCCAGGACCCTCGTC	0.627000													6	25					2.0095e-06	2.42375e-06	0.248553	1	0
LILRA1	11024	broad.mit.edu	37	19	55107691	55107691	+	Silent	SNP	G	G	A	rs141507463		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:55107691G>A	ENST00000251372.3	+	7	1178	c.996G>A	c.(994-996)ccG>ccA	p.P332P	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	332	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CGGTGCATCCGGGCCCCACGG	0.627000													15	54					0	0	0.500413	0	0
CEP57	9702	broad.mit.edu	37	11	95532434	95532434	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:95532434G>T	ENST00000325542.5	+	2	322	c.84G>T	c.(82-84)atG>atT	p.M28I	CEP57_ENST00000537677.1_Start_Codon_SNP_p.M1I|CEP57_ENST00000325486.5_Missense_Mutation_p.M28I|CEP57_ENST00000538658.1_Missense_Mutation_p.M28I|CEP57_ENST00000541150.1_Missense_Mutation_p.M19I	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	28					fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATGGAAGCATGGTTCGGCATT	0.393000									Mosaic Variegated Aneuploidy Syndrome				23	43					1.64293e-13	2.45703e-13	0.654019	1	0
NFKB1	4790	broad.mit.edu	37	4	103505875	103505875	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:103505875A>G	ENST00000226574.4	+	11	1431	c.964A>G	c.(964-966)Att>Gtt	p.I322V	NFKB1_ENST00000505458.1_Missense_Mutation_p.I321V|NFKB1_ENST00000394820.4_Missense_Mutation_p.I321V|NFKB1_ENST00000600343.1_Missense_Mutation_p.I141V	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	321	RHD.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GTATAAAGATATTAATATTAC	0.368000													10	48					0	0	0.435327	0	0
FLG	2312	broad.mit.edu	37	1	152282972	152282972	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:152282972C>T	ENST00000368799.1	-	3	4425	c.4390G>A	c.(4390-4392)Gga>Aga	p.G1464R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1464	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTTGTCTTCCTCCAGTGCTG	0.572000									Ichthyosis				142	164					0	0	0.870114	0	0
GNA11	2767	broad.mit.edu	37	19	3121014	3121014	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:3121014G>T	ENST00000078429.4	+	7	1159	c.917G>T	c.(916-918)cGg>cTg	p.R306L	GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	306					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		CAGGCGGCGCGGGAGTTCATC	0.652000			Mis		uveal melanoma								8	50					0.000673444	0.000740012	0.361761	1	0
AGO3	192669	broad.mit.edu	37	1	36505906	36505906	+	Splice_Site	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:36505906A>T	ENST00000373191.4	+	16	2386		c.e16-1		AGO3_ENST00000246314.6_Splice_Site	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		CATATTCTCTAGGTATTATAT	0.318000													3	22					0	0	0.115264	0	0
GAB3	139716	broad.mit.edu	37	X	153944568	153944568	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153944568G>T	ENST00000369575.3	-	2	140	c.109C>A	c.(109-111)Cgc>Agc	p.R37S	GAB3_ENST00000424127.2_Missense_Mutation_p.R37S|GAB3_ENST00000496390.1_5'UTR	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	37	PH.									NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCGCTCATGCGGCCTCGCCGG	0.552000													8	56					1.12685e-05	1.3163e-05	0.307466	1	0
VMA21	203547	broad.mit.edu	37	X	150572142	150572142	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:150572142G>C	ENST00000330374.6	+	2	198	c.93G>C	c.(91-93)ctG>ctC	p.L31L	VMA21_ENST00000370361.1_Silent_p.L86L|VMA21_ENST00000477649.1_3'UTR	NM_001017980.3	NP_001017980.1	Q3ZAQ7	VMA21_HUMAN	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)	31					vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	7						AGACGCTCCTGTTCTTCACAG	0.343000													47	170					0	0	0.870114	0	0
ROBO2	6092	broad.mit.edu	37	3	77684089	77684089	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:77684089G>C	ENST00000461745.1	+	24	4729	c.3829G>C	c.(3829-3831)Gca>Cca	p.A1277P	ROBO2_ENST00000332191.8_Missense_Mutation_p.A1338P|ROBO2_ENST00000487694.3_Missense_Mutation_p.A1293P	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1277					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TAACACCAGTGCAGCCCTGAG	0.488000													24	81					0	0	0.706142	0	0
CKAP2	26586	broad.mit.edu	37	13	53039445	53039445	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:53039445G>A	ENST00000378037.5	+	6	1414	c.1324G>A	c.(1324-1326)Gat>Aat	p.D442N	CKAP2_ENST00000490903.1_Missense_Mutation_p.D393N|CKAP2_ENST00000378034.3_Missense_Mutation_p.D441N|CKAP2_ENST00000258607.5_Missense_Mutation_p.D441N	NM_001098525.1|NM_018204.3	NP_001091995.1|NP_060674.3	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2	442					apoptosis|cell cycle	centrosome|microtubule|spindle pole				breast(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(3)|skin(1)|urinary_tract(1)	20		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		TCCAAAAGAAGATATACTGGT	0.323000													12	45					0	0	0.520397	0	0
ORC6	23594	broad.mit.edu	37	16	46727058	46727058	+	Missense_Mutation	SNP	C	C	T	rs3218745	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:46727058C>T	ENST00000566860.1	+	3	553	c.266C>T	c.(265-267)cCa>cTa	p.P89L	ORC6_ENST00000219097.2_Missense_Mutation_p.P138L|ORC6_ENST00000568364.2_Missense_Mutation_p.P138L			Q9Y5N6	ORC6_HUMAN	origin recognition complex, subunit 6	138					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA binding|protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8						TTATCCAGGCCACTTTTCACT	0.388000													23	94					0	0	0.693898	0	0
BMP15	9210	broad.mit.edu	37	X	50654094	50654094	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:50654094T>C	ENST00000252677.3	+	1	311	c.311T>C	c.(310-312)gTg>gCg	p.V104A		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	104					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TTGACCAATGTGGCAAGGCCT	0.562000													3	7					0	0	0.115264	0	0
MGAT3	4248	broad.mit.edu	37	22	39883366	39883366	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:39883366G>A	ENST00000341184.6	+	2	229	c.14G>A	c.(13-15)cGc>cAc	p.R5H		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	5					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					AAGATGAGACGCTACAAGCTC	0.567000													60	77					0	0	0.870114	0	0
ZNF594	84622	broad.mit.edu	37	17	5085270	5085270	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:5085270T>A	ENST00000399604.4	-	1	2422	c.2282A>T	c.(2281-2283)tAt>tTt	p.Y761F	ZNF594_ENST00000575779.1_Missense_Mutation_p.Y761F			Q96JF6	ZN594_HUMAN	zinc finger protein 594	761					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						ATTACACCAATAAACTTTCTT	0.413000													14	139					0	0	0.479597	0	0
TLR4	7099	broad.mit.edu	37	9	120475148	120475148	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:120475148C>A	ENST00000355622.6	+	3	843	c.742C>A	c.(742-744)Caa>Aaa	p.Q248K	TLR4_ENST00000394487.4_Missense_Mutation_p.Q208K|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	248					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AACTTGTATTCAAGGTCTGGC	0.348000													8	53					0.00307968	0.00329718	0.278610	1	0
RHD	6007	broad.mit.edu	37	1	25633133	25633133	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:25633133G>C	ENST00000328664.4	+	7	1141	c.986G>C	c.(985-987)gGc>gCc	p.G329A	RHD_ENST00000568195.1_Missense_Mutation_p.G329A|RHD_ENST00000357542.4_Missense_Mutation_p.G329A|RHD_ENST00000423810.2_Missense_Mutation_p.G329A|RHD_ENST00000454452.2_Intron|RHD_ENST00000342055.5_Missense_Mutation_p.G329A|RHD_ENST00000417538.2_Intron|RHD_ENST00000423253.1_Intron	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	329						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCATCATGGGCTACAACTTC	0.532000													36	77					0	0	0.819951	0	0
KYNU	8942	broad.mit.edu	37	2	143718272	143718272	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:143718272G>T	ENST00000264170.4	+	8	920	c.662G>T	c.(661-663)aGt>aTt	p.S221I	KYNU_ENST00000409512.1_Missense_Mutation_p.S221I|KYNU_ENST00000375773.2_Missense_Mutation_p.S221I	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	221					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ATCCTGTTCAGTGGGGTGCAT	0.428000													11	85					0.00010058	0.000114093	0.411799	1	0
SLC6A3	6531	broad.mit.edu	37	5	1406400	1406400	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:1406400A>G	ENST00000270349.9	-	12	1629	c.1502T>C	c.(1501-1503)gTt>gCt	p.V501A	SLC6A3_ENST00000453492.2_Missense_Mutation_p.V501A	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	501					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GAACTGCCCAACACCTGAGGG	0.642000													18	192					0	0	0.557998	0	0
MRM1	79922	broad.mit.edu	37	17	34964728	34964728	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:34964728G>T	ENST00000250156.7	+	5	1178	c.939G>T	c.(937-939)gaG>gaT	p.E313D	MRM1_ENST00000585770.1_Missense_Mutation_p.E118D	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	313					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TCCCCACAGAGGGGGAGAGAA	0.567000													87	141					9.01214e-43	1.68851e-42	0.870114	1	0
ALG13	79868	broad.mit.edu	37	X	110980035	110980035	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:110980035A>T	ENST00000394780.3	+	23	2635	c.2623A>T	c.(2623-2625)Agt>Tgt	p.S875C	ALG13_ENST00000251943.4_Missense_Mutation_p.S771C|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	875					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TCAAGCTATTAGTACCACTTC	0.458000													27	249					0	0	0.769981	0	0
KCND1	3750	broad.mit.edu	37	X	48822636	48822636	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:48822636C>A	ENST00000218176.3	-	5	2841	c.1544G>T	c.(1543-1545)aGc>aTc	p.S515I	KCND1_ENST00000376477.1_Missense_Mutation_p.S138I	NM_004979.4	NP_004970.3	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 1	515						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						CACAGAGGTGCTACGGCTGGT	0.647000													4	8					0.000602214	0.000663929	0.184627	1	0
CNTRL	11064	broad.mit.edu	37	9	123900925	123900925	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:123900925A>T	ENST00000373855.1	+	16	2565	c.2305A>T	c.(2305-2307)Agt>Tgt	p.S769C	CNTRL_ENST00000373850.1_Missense_Mutation_p.S217C|CNTRL_ENST00000373847.1_Missense_Mutation_p.S217C|CNTRL_ENST00000238341.5_Missense_Mutation_p.S769C			Q7Z7A1	CNTRL_HUMAN	centriolin	769					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GCAAGAGAACAGTGAGCTCCA	0.413000													10	56					0	0	0.411799	0	0
FSCB	84075	broad.mit.edu	37	14	44975613	44975613	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:44975613C>A	ENST00000340446.4	-	1	869	c.578G>T	c.(577-579)aGt>aTt	p.S193I		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	193						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AGGGTGTTCACTAGCAAAAAT	0.388000													40	115					1.96642e-18	3.26269e-18	0.827153	1	0
KIF21A	55605	broad.mit.edu	37	12	39734749	39734749	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:39734749C>A	ENST00000395670.3	-	15	2488	c.2069G>T	c.(2068-2070)cGg>cTg	p.R690L	KIF21A_ENST00000541463.2_Missense_Mutation_p.R677L|KIF21A_ENST00000361418.5_Missense_Mutation_p.R690L|KIF21A_ENST00000544797.2_Missense_Mutation_p.R677L|KIF21A_ENST00000361961.3_Missense_Mutation_p.R677L			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	690					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CTGAGTATCCCGAATTTTATG	0.343000													10	23					0.00010058	0.000114093	0.411799	1	0
ATRNL1	26033	broad.mit.edu	37	10	117075220	117075220	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:117075220A>G	ENST00000355044.3	+	18	3137	c.3011A>G	c.(3010-3012)tAt>tGt	p.Y1004C	ATRNL1_ENST00000303745.7_5'UTR|ATRNL1_ENST00000423111.2_Missense_Mutation_p.Y101C	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1004	PSI 5.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GAAAAGAACTATGAGTGGTCC	0.388000													13	80					0	0	0.457914	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433914	73433914	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:73433914C>T	ENST00000263666.4	-	10	1917	c.1803G>A	c.(1801-1803)gcG>gcA	p.A601A	PDZRN3_ENST00000466780.1_Silent_p.A258A|PDZRN3_ENST00000535920.1_Silent_p.A323A|PDZRN3_ENST00000479530.1_Silent_p.A318A|PDZRN3_ENST00000462146.2_Silent_p.A258A	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	601							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCCTCTGCCCCGCCAGCGGGT	0.647000													6	37					0	0	0.217242	0	0
LPPR4	9890	broad.mit.edu	37	1	99753678	99753678	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:99753678G>T	ENST00000370185.3	+	2	877	c.380G>T	c.(379-381)aGc>aTc	p.S127I	LPPR4_ENST00000457765.1_Missense_Mutation_p.S127I	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		127							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ATGTTGCTTAGCTTGGCTTTT	0.418000													9	80					1.08611e-07	1.39047e-07	0.387290	1	0
PLEKHS1	79949	broad.mit.edu	37	10	115528589	115528589	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:115528589C>A	ENST00000361048.1	+	6	702	c.375C>A	c.(373-375)gaC>gaA	p.D125E	PLEKHS1_ENST00000369310.3_Missense_Mutation_p.D119E|PLEKHS1_ENST00000369312.4_Missense_Mutation_p.D37E	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		AGATTAAAGACTGGGTCTCCT	0.403000													5	34					2.0095e-06	2.42375e-06	0.248553	1	0
CHRNB2	1141	broad.mit.edu	37	1	154541946	154541946	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:154541946G>C	ENST00000368476.3	+	2	337	c.73G>C	c.(73-75)Ggt>Cgt	p.G25R		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	25					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	AGGGGTGTGGGGTACGGATAC	0.612000													15	24					0	0	0.575678	0	0
C20orf26	26074	broad.mit.edu	37	20	20246074	20246074	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:20246074C>A	ENST00000389656.3	+	22	2633	c.587C>A	c.(586-588)tCa>tAa	p.S196*	C20orf26_ENST00000245957.5_Intron|C20orf26_ENST00000377309.2_Intron|RP5-1096J16.1_ENST00000460400.1_RNA|C20orf26_ENST00000377293.1_Nonsense_Mutation_p.S196*			Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	0										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GGAAGAGCATCAGTGTTATTC	0.448000													29	244					1.45844e-13	2.18601e-13	0.769981	1	0
FRMPD4	9758	broad.mit.edu	37	X	12734515	12734515	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:12734515C>A	ENST00000380682.1	+	15	2443	c.1937C>A	c.(1936-1938)cCg>cAg	p.P646Q		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	646					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAGGAATCTCCGAGAGGAGCT	0.522000													19	135					0.000132079	0.000149316	0.575678	1	0
MS4A14	84689	broad.mit.edu	37	11	60183382	60183382	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:60183382A>T	ENST00000300187.6	+	5	1218	c.941A>T	c.(940-942)gAt>gTt	p.D314V	MS4A14_ENST00000531783.1_Missense_Mutation_p.D347V|MS4A14_ENST00000395005.2_Missense_Mutation_p.D297V|MS4A14_ENST00000395001.1_3'UTR|MS4A14_ENST00000531787.1_Missense_Mutation_p.D202V	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	314						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						AAACTCGAAGATATATCACCT	0.448000													7	73					0	0	0.278610	0	0
KIAA0922	23240	broad.mit.edu	37	4	154542990	154542990	+	Missense_Mutation	SNP	A	A	G	rs144748311		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:154542990A>G	ENST00000409663.3	+	28	3897	c.3845A>G	c.(3844-3846)cAg>cGg	p.Q1282R	KIAA0922_ENST00000440693.1_Missense_Mutation_p.Q1199R|KIAA0922_ENST00000409959.3_Missense_Mutation_p.Q1283R	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1282						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CCTGCTGCCCAGAGAGAGGCA	0.428000													16	33					0	0	0.592651	0	0
BNC2	54796	broad.mit.edu	37	9	16552724	16552724	+	Missense_Mutation	SNP	G	G	T	rs144242525		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:16552724G>T	ENST00000380672.4	-	5	530	c.473C>A	c.(472-474)aCc>aAc	p.T158N	BNC2_ENST00000380666.2_Missense_Mutation_p.T158N|BNC2_ENST00000545497.1_Missense_Mutation_p.T63N|BNC2_ENST00000380667.2_Missense_Mutation_p.T91N	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CTCCACTTGGGTGGGGTGGTA	0.542000													20	85					2.44723e-14	3.73525e-14	0.681144	1	0
SLC35E3	55508	broad.mit.edu	37	12	69145860	69145860	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:69145860C>A	ENST00000398004.2	+	3	834	c.562C>A	c.(562-564)Ctg>Atg	p.L188M		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	188						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			AATGCAGCTGCTGTACTACCA	0.448000													18	160					3.51602e-12	5.12049e-12	0.575678	1	0
MYO18B	84700	broad.mit.edu	37	22	26422632	26422632	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:26422632G>A	ENST00000335473.7	+	43	6942	c.6692G>A	c.(6691-6693)cGg>cAg	p.R2231Q	MYO18B_ENST00000407587.2_Missense_Mutation_p.R2232Q|MYO18B_ENST00000536101.1_Missense_Mutation_p.R2231Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2231						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTGGCTTCTCGGAGTACAAAT	0.577000													3	20					0	0	0.115264	0	0
SSX6	280657	broad.mit.edu	37	X	47970655	47970655	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:47970655A>C	ENST00000376932.2	+	4	270	c.196A>C	c.(196-198)Acc>Ccc	p.T66P	SSX6_ENST00000319275.3_5'UTR																large_intestine(6)|lung(4)|skin(2)|stomach(1)	13						TTTCAACGTCACCCTCTCACT	0.478000													5	29					0	0	0.248553	0	0
KYNU	8942	broad.mit.edu	37	2	143742717	143742717	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:143742717G>A	ENST00000264170.4	+	9	1052	c.794G>A	c.(793-795)tGg>tAg	p.W265*	KYNU_ENST00000409512.1_Nonsense_Mutation_p.W265*|KYNU_ENST00000375773.2_Nonsense_Mutation_p.W265*	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	265					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTACATGACTGGGGAGTTGAT	0.378000													34	62					0	0	0.840704	0	0
NXT2	55916	broad.mit.edu	37	X	108780244	108780244	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:108780244G>C	ENST00000218004.1	+	2	276	c.174G>C	c.(172-174)acG>acC	p.T58T	NXT2_ENST00000372106.1_Silent_p.T3T|NXT2_ENST00000372107.1_5'UTR	NM_018698.4	NP_061168.2	Q9NPJ8	NXT2_HUMAN	nuclear transport factor 2-like export factor 2	3	NTF2.				mRNA transport|protein transport	cytoplasm|nucleus				endometrium(3)|large_intestine(1)|lung(1)|ovary(1)	6						AGATGGCCACGTCTCTGGTGA	0.632000													17	23					0	0	0.539581	0	0
CSMD3	114788	broad.mit.edu	37	8	113241006	113241006	+	Missense_Mutation	SNP	C	C	A	rs146402594		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:113241006C>A	ENST00000297405.5	-	70	11187	c.10943G>T	c.(10942-10944)gGa>gTa	p.G3648V	CSMD3_ENST00000455883.2_Missense_Mutation_p.G3479V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G3608V|CSMD3_ENST00000352409.3_Missense_Mutation_p.G3578V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3648						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAGATAAAATCCAAATCCTGC	0.313000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	57					1.024e-07	1.31855e-07	0.184627	1	0
SPAG9	9043	broad.mit.edu	37	17	49119004	49119004	+	Missense_Mutation	SNP	C	C	G	rs139684309		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:49119004C>G	ENST00000262013.7	-	5	807	c.599G>C	c.(598-600)cGc>cCc	p.R200P	SPAG9_ENST00000505279.1_Missense_Mutation_p.R200P|SPAG9_ENST00000357122.4_Missense_Mutation_p.R200P|SPAG9_ENST00000510283.1_Missense_Mutation_p.R57P	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	200					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TGATATAGGGCGTTCTTTTCT	0.403000													47	90					0	0	0.870114	0	0
CNTN6	27255	broad.mit.edu	37	3	1363501	1363501	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:1363501G>C	ENST00000446702.2	+	8	1556	c.929G>C	c.(928-930)gGt>gCt	p.G310A	CNTN6_ENST00000350110.2_Missense_Mutation_p.G310A|CNTN6_ENST00000539053.1_Missense_Mutation_p.G238A			Q9UQ52	CNTN6_HUMAN	contactin 6	310					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTTGCAAAGGGTCAACTCATT	0.358000													20	97					0	0	0.681144	0	0
PML	5371	broad.mit.edu	37	15	74328003	74328003	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:74328003G>T	ENST00000268059.6	+	8	2297	c.2201G>T	c.(2200-2202)cGc>cTc	p.R734L	PML_ENST00000569965.1_Intron|PML_ENST00000563500.1_3'UTR|PML_ENST00000565898.1_Intron|PML_ENST00000564428.1_Intron|PML_ENST00000436891.3_3'UTR|PML_ENST00000435786.2_3'UTR|PML_ENST00000395132.2_Intron|PML_ENST00000395135.3_Intron|PML_ENST00000359928.4_Intron|PML_ENST00000354026.6_Missense_Mutation_p.R686L|PML_ENST00000268058.3_Intron	NM_033239.2|NM_033244.3	NP_150242.1|NP_150247.2	P29590	PML_HUMAN	promyelocytic leukemia	0					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						TCCCGCAGCCGCTCCCTCCGG	0.617000			T	"""RARA, PAX5"""	"""APL, ALL"""								39	76					3.86236e-30	7.0196e-30	0.870114	1	0
CES1	1066	broad.mit.edu	37	16	55855375	55855375	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:55855375G>A	ENST00000422046.2	-	5	876	c.595C>T	c.(595-597)Cgc>Tgc	p.R199C	CES1_ENST00000566555.1_5'UTR|CES1_ENST00000361503.4_Missense_Mutation_p.R199C|CES1_ENST00000360526.3_Missense_Mutation_p.R200C			P23141	EST1_HUMAN	carboxylesterase 1	199			R -> H (in dbSNP:rs2307243).		response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TGGACCCAGCGCAGGGCAGCC	0.587000													8	44					0	0	0.335167	0	0
PNPLA6	10908	broad.mit.edu	37	19	7619157	7619157	+	Splice_Site	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:7619157A>T	ENST00000221249.6	+	23	2781	c.2351_splice	c.e23+1	p.S784_splice	PNPLA6_ENST00000600737.1_Splice_Site_p.S822_splice|PNPLA6_ENST00000450331.3_Splice_Site_p.S784_splice|PNPLA6_ENST00000545201.2_Splice_Site_p.S757_splice|PNPLA6_ENST00000414982.3_Splice_Site_p.S832_splice	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	823					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CGCACTGGATAGGTGTGTGTT	0.597000													31	266					0	0	0.840704	0	0
ZNF679	168417	broad.mit.edu	37	7	63726795	63726795	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:63726795C>A	ENST00000421025.1	+	5	1053	c.784C>A	c.(784-786)Cat>Aat	p.H262N	ZNF679_ENST00000255746.4_Missense_Mutation_p.H262N	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						TAGGAGAATTCATACTGGAGA	0.418000													16	30					2.35188e-11	3.35193e-11	0.539581	1	0
AOC1	26	broad.mit.edu	37	7	150554515	150554515	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:150554515C>G	ENST00000493429.1	+	4	1541	c.957C>G	c.(955-957)taC>taG	p.Y319*	AOC1_ENST00000360937.4_Nonsense_Mutation_p.Y319*|AOC1_ENST00000467291.1_Nonsense_Mutation_p.Y319*|AOC1_ENST00000416793.2_Nonsense_Mutation_p.Y319*					amine oxidase, copper containing 1																		CTGTGCTCTACGGCGGCTGGA	0.692000													14	13					0	0	0.500413	0	0
CYP19A1	1588	broad.mit.edu	37	15	51514549	51514549	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:51514549C>A	ENST00000396402.1	-	5	778	c.625G>T	c.(625-627)Gac>Tac	p.D209Y	CYP19A1_ENST00000396404.4_Missense_Mutation_p.D209Y|CYP19A1_ENST00000557858.1_Missense_Mutation_p.D209Y|CYP19A1_ENST00000559878.1_Missense_Mutation_p.D209Y|CYP19A1_ENST00000405913.3_Missense_Mutation_p.D209Y|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000260433.2_Missense_Mutation_p.D209Y	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	209					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TCAGTACCGTCCAAAGGGATC	0.483000													26	43					7.01153e-11	9.84567e-11	0.717897	1	0
CFHR2	3080	broad.mit.edu	37	1	196927039	196927039	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:196927039G>T	ENST00000367415.4	+	4	563	c.449G>T	c.(448-450)gGg>gTg	p.G150V	CFHR2_ENST00000476712.1_3'UTR|CFHR2_ENST00000367421.3_Missense_Mutation_p.G150V	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	150	Sushi 3.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						GAAAAATGTGGGCCCCCTCCA	0.373000													14	84					0.00400662	0.00427587	0.500413	1	0
MVB12A	93343	broad.mit.edu	37	19	17534512	17534512	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:17534512C>G	ENST00000317040.7	+	6	1599	c.544C>G	c.(544-546)Ctc>Gtc	p.L182V	MVB12A_ENST00000392702.2_Missense_Mutation_p.L142V|MVB12A_ENST00000543795.1_Missense_Mutation_p.L182V|MVB12A_ENST00000528515.1_Silent_p.A139A|MVB12A_ENST00000529939.1_Missense_Mutation_p.L182V					multivesicular body subunit 12A																		TAAGGGCGGCCTCCTGGAGCG	0.627000													35	127					0	0	0.870114	0	0
NID2	22795	broad.mit.edu	37	14	52535582	52535582	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:52535582C>T	ENST00000216286.5	-	1	130	c.131G>A	c.(130-132)gGg>gAg	p.G44E	NID2_ENST00000541773.1_Intron	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	44				G -> W (in Ref. 2; BAA13087 and 3; BAA24112).		basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GAGCTGGTCCCCCCACGACTC	0.622000													5	69					0	0	0.184627	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42133062	42133062	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:42133062G>C	ENST00000382448.4	+	9	1012	c.1003G>C	c.(1003-1005)Gct>Cct	p.A335P	JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.A104P|JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.A335P|PLA2G4B_ENST00000452633.1_Missense_Mutation_p.A104P	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		104	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GACTCTGCGGGCTGGGGAGTT	0.587000													25	52					0	0	0.729181	0	0
HAAO	23498	broad.mit.edu	37	2	43019611	43019611	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:43019611G>T	ENST00000294973.6	-	1	121	c.66C>A	c.(64-66)gtC>gtA	p.V22V		NM_012205.2	NP_036337.2	P46952	3HAO_HUMAN	3-hydroxyanthranilate 3,4-dioxygenase	22	Domain A (catalytic) (By similarity).				neuron homeostasis|pyridine nucleotide biosynthetic process|quinolinate biosynthetic process|response to cadmium ion|response to zinc ion|tryptophan catabolic process	cytosol|soluble fraction	3-hydroxyanthranilate 3,4-dioxygenase activity|electron carrier activity|ferrous iron binding			breast(2)|cervix(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(2)	11						GCTTGTTGCAGACCGGGGGCT	0.697000													6	70					0.00448238	0.00475318	0.307466	1	0
LCP1	3936	broad.mit.edu	37	13	46716539	46716539	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:46716539C>A	ENST00000398576.2	-	16	1778	c.1390G>T	c.(1390-1392)Gta>Tta	p.V464L	LCP1_ENST00000323076.2_Missense_Mutation_p.V464L|LCP1_ENST00000435666.2_Missense_Mutation_p.V33L			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	464	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		CCCAATTCTACCGCGTAGTTA	0.398000			T	BCL6	NHL								12	72					9.31168e-06	1.09154e-05	0.435327	1	0
PCDHB18P	54660	broad.mit.edu	37	5	140615647	140615647	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140615647C>A	ENST00000526308.1	+	0	1710					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						TCTCCATCAACGCGGACAACG	0.677000													27	215					8.4185e-14	1.26753e-13	0.760397	1	0
ERN2	10595	broad.mit.edu	37	16	23724581	23724581	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:23724581C>T	ENST00000256797.4	-	1	240	c.72G>A	c.(70-72)ccG>ccA	p.P24P		NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	0					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCGCCCGACCCGGAGAAGGCT	0.721000													3	16					0	0	0.150653	0	0
FUS	2521	broad.mit.edu	37	16	31202352	31202352	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:31202352G>T	ENST00000254108.7	+	14	1567	c.1462G>T	c.(1462-1464)Ggc>Tgc	p.G488C	FUS_ENST00000380244.3_Missense_Mutation_p.G487C|FUS_ENST00000568685.1_Missense_Mutation_p.G489C|FUS_ENST00000474990.1_3'UTR	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	488	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding	p.G488S(1)	FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		CCGGGGCCGCGGCGGGGACCG	0.577000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								17	49					6.94344e-10	9.47091e-10	0.539581	1	0
RPL27A	6157	broad.mit.edu	37	11	8704331	8704331	+	Translation_Start_Site	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:8704331A>T	ENST00000314138.6	+	0	374					NM_000990.4	NP_000981.1	P46776	RL27A_HUMAN	ribosomal protein L27a						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2				Epithelial(150;3.24e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GACTTGGCGAAGGCCTTCCTT	0.637000													25	47					0	0	0.740014	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615555	140615555	+	RNA	SNP	G	G	T	rs10599878		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140615555G>T	ENST00000526308.1	+	0	1618					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						CAGCGCTACAGACAGAGACTC	0.637000													42	191					3.33635e-10	4.64582e-10	0.859065	1	0
MCF2	4168	broad.mit.edu	37	X	138698515	138698515	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:138698515C>A	ENST00000520602.1	-	12	1582	c.1297G>T	c.(1297-1299)Gct>Tct	p.A433S	MCF2_ENST00000414978.1_Missense_Mutation_p.A433S|MCF2_ENST00000370573.4_Missense_Mutation_p.A373S|MCF2_ENST00000370576.4_Missense_Mutation_p.A373S|MCF2_ENST00000536274.1_Missense_Mutation_p.A334S|MCF2_ENST00000370578.4_Missense_Mutation_p.A518S|MCF2_ENST00000338585.6_Missense_Mutation_p.A373S|MCF2_ENST00000519895.1_Missense_Mutation_p.A433S			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	373					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					AAGGGTAGAGCCATTTCAAGA	0.328000													13	38					0.00010058	0.000114093	0.411799	1	0
DGKI	9162	broad.mit.edu	37	7	137282607	137282607	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:137282607C>A	ENST00000453654.1	-	12	936	c.397G>T	c.(397-399)Ggt>Tgt	p.G133C	DGKI_ENST00000288490.5_Missense_Mutation_p.G433C|DGKI_ENST00000424189.2_Missense_Mutation_p.G433C|DGKI_ENST00000446122.1_Missense_Mutation_p.G433C			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	433					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CCATCCCCACCACAGGCCAGA	0.408000													17	33					7.92952e-12	1.13987e-11	0.667858	1	0
CACNA1G	8913	broad.mit.edu	37	17	48674226	48674226	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:48674226G>T	ENST00000352832.5	+	15	3503	c.3131G>T	c.(3130-3132)cGc>cTc	p.R1044L	CACNA1G_ENST00000515765.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.R1067L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.R1044L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.R1044L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.R1044L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.R1044L|CACNA1G_ENST00000512389.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.R1044L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.R1067L|CACNA1G_ENST00000416767.4_Missense_Mutation_p.R1067L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.R1044L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.R1067L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.R1067L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.R1067L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.R1044L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1067					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGCGTCGCGCCGCACCAGC	0.692000													8	13					1.12685e-05	1.3163e-05	0.307466	1	0
HDAC6	10013	broad.mit.edu	37	X	48683010	48683010	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:48683010C>T	ENST00000334136.5	+	29	3814	c.3636C>T	c.(3634-3636)ccC>ccT	p.P1212P	HDAC6_ENST00000376619.2_Silent_p.P1212P|HDAC6_ENST00000444343.2_Silent_p.P1226P			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1212					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	AGGATATGCCCCACCCACACT	0.552000													16	55					0	0	0.557998	0	0
JAK3	3718	broad.mit.edu	37	19	17937621	17937621	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:17937621G>A	ENST00000458235.1	-	24	3405	c.3306C>T	c.(3304-3306)agC>agT	p.S1102S	JAK3_ENST00000527670.1_Silent_p.S1102S	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	1102	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CACACCCCCGGCTTCCGCTCC	0.617000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								39	142					0	0	0.859065	0	0
CSMD3	114788	broad.mit.edu	37	8	113349771	113349771	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:113349771C>A	ENST00000297405.5	-	43	7086		c.e43+1		CSMD3_ENST00000455883.2_Splice_Site|CSMD3_ENST00000343508.3_Splice_Site|CSMD3_ENST00000352409.3_Splice_Site	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3							integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAGAAGCATACCTTCACACCT	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	80					1.024e-07	1.31855e-07	0.184627	1	0
F13A1	2162	broad.mit.edu	37	6	6318830	6318830	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:6318830G>A	ENST00000264870.3	-	2	333	c.68C>T	c.(67-69)gCg>gTg	p.A23V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	23					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GTCATCTTCCGCTGCATTAGA	0.532000													15	124					0	0	0.539581	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678512	37678512	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:37678512G>T	ENST00000379800.3	-	1	1291	c.882C>A	c.(880-882)taC>taA	p.Y294*		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	294					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AATCAAATGTGTAGTCATATT	0.512000													20	76					3.62473e-10	5.00558e-10	0.608945	1	0
FAM47C	442444	broad.mit.edu	37	X	37027216	37027216	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37027216C>A	ENST00000358047.3	+	1	785	c.733C>A	c.(733-735)Cat>Aat	p.H245N		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	245										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGGAGTGTCCCATCTCCGCCC	0.637000													36	73					6.5261e-18	1.07745e-17	0.840704	1	0
SPERT	220082	broad.mit.edu	37	13	46288400	46288400	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:46288400A>G	ENST00000378966.3	+	2	1548	c.1132A>G	c.(1132-1134)Att>Gtt	p.I378V	SPERT_ENST00000310521.1_Missense_Mutation_p.I414V			Q8NA61	SPERT_HUMAN	spermatid associated	414						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GAAGCTGGTCATTGACACCGT	0.612000													3	10					0	0	0.115264	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325905	79325905	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:79325905C>T	ENST00000428286.1	-	8	1408	c.208G>A	c.(208-210)Gga>Aga	p.G70R	PRUNE2_ENST00000376718.3_Missense_Mutation_p.G429R			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	429					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTAGCCAGTCCGCTGTCTGGG	0.542000													5	23					0	0	0.217242	0	0
TRPA1	8989	broad.mit.edu	37	8	72964945	72964945	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:72964945A>G	ENST00000262209.4	-	14	1907	c.1700T>C	c.(1699-1701)cTt>cCt	p.L567P	RP11-383H13.1_ENST00000457356.4_3'UTR|RP11-383H13.1_ENST00000537896.1_3'UTR|RP11-383H13.1_ENST00000524152.1_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	567						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GTGGCTCAGAAGAAGCGCAAC	0.473000													29	67					0	0	0.750413	0	0
TMEFF2	23671	broad.mit.edu	37	2	192863878	192863878	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:192863878T>A	ENST00000392314.1	-	6	984	c.593A>T	c.(592-594)gAt>gTt	p.D198V	TMEFF2_ENST00000487771.1_5'UTR|AC098617.1_ENST00000428980.2_RNA|AC098617.1_ENST00000424116.2_RNA|TMEFF2_ENST00000272771.5_Missense_Mutation_p.D198V			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	198	Kazal-like 2.					extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AGATTTCCCATCAGAAGCGCA	0.368000													12	43					0	0	0.411799	0	0
GRM6	2916	broad.mit.edu	37	5	178410105	178410105	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:178410105C>T	ENST00000231188.5	-	9	2420	c.2242G>A	c.(2242-2244)Gat>Aat	p.D748N	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.D748N	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	748					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGAGACAGATCCGACATGTCG	0.637000													12	76					0	0	0.479597	0	0
PXDNL	137902	broad.mit.edu	37	8	52322095	52322095	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:52322095G>T	ENST00000356297.4	-	17	2189	c.2089C>A	c.(2089-2091)Ccg>Acg	p.P697T	PXDNL_ENST00000543296.1_Missense_Mutation_p.P697T	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	697					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGGGAGCGCGGGGACACCAAG	0.607000													8	46					7.48243e-07	9.2251e-07	0.335167	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140730188	140730188	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140730188C>G	ENST00000523390.1	+	1	361	c.361C>G	c.(361-363)Caa>Gaa	p.Q121E	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTGTAATCCAAGATATTAA	0.423000													10	33					0	0	0.335167	0	0
ANKRD44	91526	broad.mit.edu	37	2	197870629	197870629	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:197870629C>A	ENST00000328737.2	-	21	2137	c.2061G>T	c.(2059-2061)atG>atT	p.M687I	ANKRD44_ENST00000337207.5_Missense_Mutation_p.M687I|ANKRD44_ENST00000282272.8_Missense_Mutation_p.M704I|ANKRD44_ENST00000450567.1_Missense_Mutation_p.M687I			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	712							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CGTGTCCTGTCATAATCTGAT	0.453000													53	75					9.90819e-18	1.62777e-17	0.870114	1	0
OR13H1	347468	broad.mit.edu	37	X	130678891	130678891	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:130678891C>T	ENST00000338616.3	+	1	942	c.844C>T	c.(844-846)Ccc>Tcc	p.P282S		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					AGCTTTGACACCCATGTTGAA	0.403000													23	100					0	0	0.693898	0	0
CEACAM20	125931	broad.mit.edu	37	19	45017236	45017236	+	RNA	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:45017236G>T	ENST00000454753.1	-	0	1700							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				GTTACCGTCTGGCATTTCTGA	0.587000											OREG0025538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	36					7.48243e-07	9.2251e-07	0.335167	1	0
DNASE2B	58511	broad.mit.edu	37	1	84878181	84878181	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:84878181C>A	ENST00000370665.3	+	5	730	c.697C>A	c.(697-699)Cag>Aag	p.Q233K	DNASE2B_ENST00000370662.3_Missense_Mutation_p.Q25K	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	233					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TCAGTCGGCCCAGGGACAAAA	0.493000													16	47					1.15088e-07	1.46775e-07	0.500413	1	0
CASC5	57082	broad.mit.edu	37	15	40951637	40951637	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:40951637C>G	ENST00000346991.5	+	26	7282	c.6892C>G	c.(6892-6894)Cag>Gag	p.Q2298E	CASC5_ENST00000399668.2_Missense_Mutation_p.Q2272E			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	2298	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTCCACCATTCAGAATCACGT	0.433000													29	69					0	0	0.812448	0	0
AMER1	139285	broad.mit.edu	37	X	63411865	63411865	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:63411865G>T	ENST00000330258.3	-	2	1574	c.1302C>A	c.(1300-1302)caC>caA	p.H434Q	AMER1_ENST00000403336.1_Missense_Mutation_p.H434Q|AMER1_ENST00000374869.3_Missense_Mutation_p.H434Q	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GCATGTAGCCGTGGTGGCCTG	0.527000													49	110					4.76918e-47	9.0628e-47	0.870114	1	0
AOC4P	90586	broad.mit.edu	37	17	41020306	41020306	+	RNA	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:41020306C>T	ENST00000585538.1	+	0	1145					NR_002773.1																						GGACTTTCTCCTTTGGCCTCG	0.617000													6	47					0	0	0.335167	0	0
CCDC129	223075	broad.mit.edu	37	7	31691640	31691640	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:31691640G>T	ENST00000319386.3	+	13	3348	c.2355G>T	c.(2353-2355)caG>caT	p.Q785H	CCDC129_ENST00000407970.3_Missense_Mutation_p.Q933H|CCDC129_ENST00000451887.2_Missense_Mutation_p.Q959H|CCDC129_ENST00000409210.1_Missense_Mutation_p.Q841H			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	933										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						ACCGGGCTCAGCAAATCAGAG	0.493000													8	13					7.48243e-07	9.2251e-07	0.335167	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253806	32253806	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:32253806C>A	ENST00000332378.4	-	1	68	c.38G>T	c.(37-39)aGg>aTg	p.R13M		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	13						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						TCCAATGGGCCTGGAAGAGCA	0.532000													32	85					5.71845e-15	8.95354e-15	0.812448	1	0
GRM7	2917	broad.mit.edu	37	3	7340477	7340477	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:7340477G>T	ENST00000486284.1	+	3	1117	c.843G>T	c.(841-843)agG>agT	p.R281S	GRM7_ENST00000357716.4_Missense_Mutation_p.R281S|GRM7_ENST00000389336.4_Missense_Mutation_p.R281S|GRM7_ENST00000402647.2_Missense_Mutation_p.R281S|GRM7_ENST00000403881.1_Missense_Mutation_p.R281S	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	281					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCAACTCCAGGGCCGTCGTGA	0.443000													13	46					2.61681e-11	3.71365e-11	0.457914	1	0
KCTD8	386617	broad.mit.edu	37	4	44176871	44176871	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:44176871G>T	ENST00000360029.3	-	2	1641	c.1358C>A	c.(1357-1359)cCa>cAa	p.P453Q		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	453						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						AAAATAATCTGGAATGTGGAT	0.373000										HNSCC(17;0.042)			18	62					2.37509e-13	3.54404e-13	0.592651	1	0
OR5T2	219464	broad.mit.edu	37	11	55999873	55999873	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:55999873G>T	ENST00000313264.4	-	1	864	c.789C>A	c.(787-789)gcC>gcA	p.A263A		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TCTTCAGAATGGCCAACAGAA	0.438000													31	85					1.22384e-17	2.00565e-17	0.769981	1	0
CBLN2	147381	broad.mit.edu	37	18	70209165	70209165	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:70209165G>C	ENST00000269503.4	-	3	1004	c.231C>G	c.(229-231)gcC>gcG	p.A77A	CBLN2_ENST00000581073.1_Intron|CBLN2_ENST00000585159.1_Silent_p.A77A|CBLN2_ENST00000584764.1_Intron|CBLN2_ENST00000583651.1_Intron	NM_182511.3	NP_872317.1	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	77						integral to membrane				endometrium(2)|lung(15)	17		Esophageal squamous(42;0.131)				AGGAGGTGACGGCGCCGTCCG	0.711000													10	18					0	0	0.335167	0	0
ZNF536	9745	broad.mit.edu	37	19	30935349	30935349	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:30935349C>A	ENST00000355537.3	+	2	1027	c.880C>A	c.(880-882)Cgc>Agc	p.R294S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCGCCACATCCGCATCTTGCA	0.642000													26	68					4.31634e-10	5.94834e-10	0.760397	1	0
TRPM6	140803	broad.mit.edu	37	9	77354345	77354345	+	Silent	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:77354345A>T	ENST00000451710.3	-	34	5757	c.5520T>A	c.(5518-5520)gcT>gcA	p.A1840A	TRPM6_ENST00000449912.2_Silent_p.A1831A|TRPM6_ENST00000376864.4_Silent_p.A1840A|TRPM6_ENST00000376871.3_Silent_p.A673A|TRPM6_ENST00000376872.3_Silent_p.A791A|TRPM6_ENST00000361255.3_Silent_p.A1831A|TRPM6_ENST00000360774.1_Silent_p.A1836A			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1836	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ATTTTTGAGCAGCTCTTTGTT	0.378000													20	45					0	0	0.681144	0	0
EPYC	1833	broad.mit.edu	37	12	91363869	91363869	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:91363869G>C	ENST00000261172.3	-	6	842	c.750C>G	c.(748-750)gaC>gaG	p.D250E		NM_004950.4	NP_004941.2	Q99645	EPYC_HUMAN	epiphycan	250					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|skin(2)	18						GAGGGATGTGGTCCAAGTTGT	0.448000													53	139					0	0	0.870114	0	0
ELAVL3	1995	broad.mit.edu	37	19	11565536	11565536	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:11565536C>A	ENST00000359227.3	-	7	1333	c.909G>T	c.(907-909)ctG>ctT	p.L303L	ELAVL3_ENST00000438662.2_Silent_p.L296L	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	303	RRM 3.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						AAGGCCCGAACAGCTGCCACA	0.627000													13	111					2.23348e-06	2.68421e-06	0.500413	1	0
NDUFB11	54539	broad.mit.edu	37	X	47003880	47003880	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:47003880A>T	ENST00000377811.3	-	1	1023	c.199T>A	c.(199-201)Tat>Aat	p.Y67N	NDUFB11_ENST00000276062.8_Missense_Mutation_p.Y67N	NM_001135998.2	NP_001129470.1	Q9NX14	NDUBB_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	67					respiratory electron transport chain|transport	integral to membrane|mitochondrial respiratory chain complex I				endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	7						ACCTTCTCATACAAGTTTTCG	0.672000											OREG0019755	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	24					0	0	0.217242	0	0
FAM47C	442444	broad.mit.edu	37	X	37027474	37027474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37027474C>A	ENST00000358047.3	+	1	1043	c.991C>A	c.(991-993)Cac>Aac	p.H331N		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	331										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GTCCCATCTCCACCCAGAGCC	0.612000													37	99					1.47197e-15	2.33763e-15	0.834066	1	0
MCOLN2	255231	broad.mit.edu	37	1	85405267	85405267	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:85405267C>A	ENST00000370608.3	-	9	1146	c.1079G>T	c.(1078-1080)gGc>gTc	p.G360V	MCOLN2_ENST00000284027.5_Missense_Mutation_p.G332V|MCOLN2_ENST00000531325.1_5'UTR	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	360						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TAATATGGAGCCAATGATTGT	0.468000													9	47					0.000442599	0.000490388	0.335167	1	0
MAP3K9	4293	broad.mit.edu	37	14	71275549	71275549	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:71275549G>A	ENST00000554752.2	-	1	339	c.340C>T	c.(340-342)Cgc>Tgc	p.R114C	MAP3K9_ENST00000555993.2_Missense_Mutation_p.R114C|MAP3K9_ENST00000381250.4_Missense_Mutation_p.R114C			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	114	SH3.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		AAGGCGCTGCGCGGGGTCACG	0.711000													4	15					0	0	0.217242	0	0
MARCH4	57574	broad.mit.edu	37	2	217142526	217142526	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:217142526G>T	ENST00000273067.4	-	3	2500	c.734C>A	c.(733-735)tCc>tAc	p.S245Y		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	245						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GAGGAAGAGGGAGCCCAGGAT	0.567000													22	56					5.35356e-11	7.54931e-11	0.639603	1	0
FAT4	79633	broad.mit.edu	37	4	126411345	126411345	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:126411345G>T	ENST00000394329.3	+	17	13381	c.13368G>T	c.(13366-13368)tcG>tcT	p.S4456S	FAT4_ENST00000335110.5_Silent_p.S2697S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4456	EGF-like 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCCAGACTCGCACACGGGAA	0.637000													4	74					0.00909568	0.00946462	0.150653	1	0
DRD2	1813	broad.mit.edu	37	11	113286296	113286296	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:113286296C>A	ENST00000362072.3	-	5	914	c.570G>T	c.(568-570)gtG>gtT	p.V190V	DRD2_ENST00000542968.1_Silent_p.V190V|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000544518.1_Silent_p.V189V|DRD2_ENST00000346454.3_Silent_p.V190V|DRD2_ENST00000355319.2_Silent_p.V190V|DRD2_ENST00000538967.1_Silent_p.V190V	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	190	Agonist binding (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGGAGTAGACCACGAAGGCCG	0.597000													11	24					0.00010058	0.000114093	0.411799	1	0
OR52J3	119679	broad.mit.edu	37	11	5068583	5068583	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:5068583T>A	ENST00000380370.1	+	1	828	c.828T>A	c.(826-828)ctT>ctA	p.L276L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCACATTCTTGTTGCCAATC	0.418000													42	70					0	0	0.870114	0	0
GABRE	2564	broad.mit.edu	37	X	151123380	151123380	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:151123380G>T	ENST00000370328.3	-	9	1367	c.1314C>A	c.(1312-1314)cgC>cgA	p.R438R	GABRE_ENST00000370325.1_3'UTR|GABRE_ENST00000483564.1_5'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	438					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGCAGAGGCTGCGGGGACCCT	0.612000													6	21					5.9392e-07	7.377e-07	0.217242	1	0
SLC38A1	81539	broad.mit.edu	37	12	46596869	46596869	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:46596869C>A	ENST00000398637.5	-	12	1520	c.826G>T	c.(826-828)Gtg>Ttg	p.V276L	SLC38A1_ENST00000549049.1_Missense_Mutation_p.V276L|SLC38A1_ENST00000552197.1_Missense_Mutation_p.V276L|SLC38A1_ENST00000546893.1_Missense_Mutation_p.V276L|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000439706.1_Missense_Mutation_p.V276L	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	276					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			AAAGCATACACGGTCTATTTG	0.358000													17	56					1.55795e-14	2.38337e-14	0.608945	1	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333385	28333385	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:28333385C>A	ENST00000377255.3	+	7	1237	c.940C>A	c.(940-942)Cac>Aac	p.H314N	ZKSCAN3_ENST00000341464.5_Missense_Mutation_p.H166N|ZKSCAN3_ENST00000252211.2_Missense_Mutation_p.H314N	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	314					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						AGGGAGGCGGCACATCTGCCA	0.498000													15	42					0.000422831	0.000470048	0.500413	1	0
MUC16	94025	broad.mit.edu	37	19	9060459	9060459	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:9060459G>T	ENST00000397910.4	-	3	27190	c.26987C>A	c.(26986-26988)tCa>tAa	p.S8996*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8998	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGGATGTTGACTCCATCTC	0.493000													27	97					2.16457e-27	3.8811e-27	0.729181	1	0
WDR27	253769	broad.mit.edu	37	6	170068147	170068147	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:170068147C>A	ENST00000333572.6	-	5	1110	c.591G>T	c.(589-591)gtG>gtT	p.V197V	WDR27_ENST00000423258.1_Intron|WDR27_ENST00000420344.2_Intron|WDR27_ENST00000448612.1_Silent_p.V197V			A2RRH5	WDR27_HUMAN	WD repeat domain 27	167										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CCACCGCAGTCACCGGGCCCA	0.617000													14	22					7.93312e-07	9.74474e-07	0.457914	1	0
ZNF99	7652	broad.mit.edu	37	19	22941360	22941360	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:22941360G>A	ENST00000397104.3	-	5	1077	c.1078C>T	c.(1078-1080)Caa>Taa	p.Q360*	ZNF99_ENST00000596209.1_Nonsense_Mutation_p.Q451*					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTGTAGGGTTGCTTTCCAGTA	0.368000													16	40					0	0	0.557998	0	0
EPHB1	2047	broad.mit.edu	37	3	134851762	134851762	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:134851762C>A	ENST00000398015.3	+	5	1538	c.1168C>A	c.(1168-1170)Cgc>Agc	p.R390S	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	390	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R390C(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GACGGAGTGCCGCGTCTCCAT	0.617000													12	32					2.27111e-07	2.869e-07	0.411799	1	0
GPC3	2719	broad.mit.edu	37	X	132887746	132887746	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:132887746G>C	ENST00000370818.3	-	3	1240	c.795C>G	c.(793-795)tgC>tgG	p.C265W	GPC3_ENST00000394299.2_Missense_Mutation_p.C265W|GPC3_ENST00000543339.1_Missense_Mutation_p.C211W	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	265						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TCAGTCCCTGGCAGTAAGAGC	0.478000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				69	237					0	0	0.870114	0	0
ADAM23	8745	broad.mit.edu	37	2	207422186	207422186	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:207422186C>A	ENST00000264377.3	+	10	1297	c.969C>A	c.(967-969)aaC>aaA	p.N323K	ADAM23_ENST00000374416.1_Missense_Mutation_p.N323K|ADAM23_ENST00000374415.3_Missense_Mutation_p.N323K	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	323	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CACATACCAACAACTTTGCAA	0.383000													13	200					2.32078e-09	3.1272e-09	0.479597	1	0
ADAMTSL4	54507	broad.mit.edu	37	1	150527914	150527914	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:150527914C>A	ENST00000271643.4	+	8	1480	c.1244C>A	c.(1243-1245)tCc>tAc	p.S415Y	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.S415Y|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.S438Y|RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.S415Y	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	415					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTCCAGGGCTCCCAGCGCTGT	0.627000													7	19					5.18039e-06	6.14826e-06	0.278610	1	0
DAGLA	747	broad.mit.edu	37	11	61488327	61488327	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:61488327G>T	ENST00000257215.5	+	3	388	c.272G>T	c.(271-273)cGt>cTt	p.R91L		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	91					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		ACGGAGCCCCGTGACTCCATG	0.642000													38	122					1.41504e-22	2.49031e-22	0.859065	1	0
FER1L5	90342	broad.mit.edu	37	2	97370250	97370250	+	RNA	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:97370250C>T	ENST00000457909.1	+	0	5498							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						TCAGCTGTATCCTCCCATTAA	0.468000													17	150					0	0	0.575678	0	0
TFB1M	51106	broad.mit.edu	37	6	155635464	155635464	+	Silent	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:155635464T>C	ENST00000367166.4	-	1	154	c.99A>G	c.(97-99)ctA>ctG	p.L33L	TFB1M_ENST00000480390.1_5'UTR	NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	33					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AATTCTGTGATAGCTGCTTCG	0.577000													5	19					0	0	0.217242	0	0
ATP4A	495	broad.mit.edu	37	19	36054119	36054119	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:36054119C>A	ENST00000262623.3	-	3	236	c.208G>T	c.(208-210)Gcc>Tcc	p.A70S		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	70					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACCTTGGTGGCACTGGTCTGG	0.617000													92	358					4.53158e-46	8.58683e-46	0.870114	1	0
C1orf173	127254	broad.mit.edu	37	1	75037744	75037744	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:75037744G>T	ENST00000326665.5	-	14	3868	c.3650C>A	c.(3649-3651)gCa>gAa	p.A1217E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1217	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCAGGAGCTGCTAAGGCCCC	0.607000													8	70					3.09899e-07	3.88538e-07	0.307466	1	0
KCNH8	131096	broad.mit.edu	37	3	19575439	19575439	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:19575439G>T	ENST00000328405.2	+	16	3438	c.3172G>T	c.(3172-3174)Gga>Tga	p.G1058*		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1058	Ser-rich.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CTTCAGTCAGGGAACTGTGAG	0.483000													10	24					0.00829132	0.00870915	0.361761	1	0
CLIP3	25999	broad.mit.edu	37	19	36509848	36509848	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:36509848G>T	ENST00000360535.4	-	9	1362	c.1135C>A	c.(1135-1137)Cgg>Agg	p.R379R	CLIP3_ENST00000593074.1_Silent_p.R379R|AC002116.7_ENST00000586962.1_RNA	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	379					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AAGTCCATCCGGGGGGTCCGG	0.612000													8	98					0.00621372	0.00655783	0.335167	1	0
CALHM1	255022	broad.mit.edu	37	10	105218003	105218003	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:105218003C>A	ENST00000329905.5	-	1	642	c.506G>T	c.(505-507)tGg>tTg	p.W169L	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	169						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						GGCCAACAGCCAGTCGCCATC	0.701000													29	69					5.71845e-15	8.95354e-15	0.812448	1	0
CCT5	22948	broad.mit.edu	37	5	10261748	10261748	+	Missense_Mutation	SNP	G	G	T	rs143444882	by1000genomes	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:10261748G>T	ENST00000280326.4	+	8	1490	c.1070G>T	c.(1069-1071)gGt>gTt	p.G357V	CCT5_ENST00000515676.1_Missense_Mutation_p.G319V|CCT5_ENST00000515390.1_Missense_Mutation_p.G302V|CCT5_ENST00000506600.1_Missense_Mutation_p.G264V|CCT5_ENST00000503026.1_Missense_Mutation_p.G336V	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	357					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GGCTTTGCTGGTCTTGTACAG	0.502000													27	318					2.24059e-21	3.90203e-21	0.706142	1	0
PRAMEF7	441871	broad.mit.edu	37	1	12979745	12979745	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:12979745T>C	ENST00000361079.2	+	4	1020	c.937T>C	c.(937-939)Tct>Cct	p.S313P						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCATCTCTCTTGGTGCCC	0.562000													10	163					0	0	0.457914	0	0
IFNL2	282616	broad.mit.edu	37	19	39759422	39759422	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:39759422G>A	ENST00000331982.5	+	2	171	c.116G>A	c.(115-117)aGg>aAg	p.R39K		NM_172138.1	NP_742150.1			interferon, lambda 2																		CCGGATGCAAGGGGCTGCCAC	0.632000													7	45					0	0	0.278610	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694567	153694567	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153694567G>T	ENST00000369682.3	+	15	2928	c.2753G>T	c.(2752-2754)tGt>tTt	p.C918F		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	918	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGGGTGACTGTTCAGCCGAC	0.672000													54	153					3.36121e-32	6.15913e-32	0.870114	1	0
OR4C46	119749	broad.mit.edu	37	11	51516002	51516002	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:51516002C>A	ENST00000328188.1	+	1	721	c.721C>A	c.(721-723)Cac>Aac	p.H241N		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						CTGTGTCTCCCACATCACGGT	0.468000													29	105					1.06801e-11	1.53197e-11	0.740014	1	0
RIMS2	9699	broad.mit.edu	37	8	104948817	104948817	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:104948817C>T	ENST00000507740.1	+	10	2026	c.1790C>T	c.(1789-1791)aCa>aTa	p.T597I	RIMS2_ENST00000436393.2_Missense_Mutation_p.T583I|RIMS2_ENST00000262231.10_Missense_Mutation_p.T644I|RIMS2_ENST00000406091.3_Missense_Mutation_p.T805I	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	867					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTAAAGAAAACATTGGAACCC	0.333000										HNSCC(12;0.0054)			6	48					0	0	0.217242	0	0
COL5A2	1290	broad.mit.edu	37	2	189907500	189907500	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:189907500C>A	ENST00000374866.3	-	49	3746		c.e49-1			NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CATTTGGACCCTAAGTAGGAA	0.378000													11	19					2.27111e-07	2.869e-07	0.411799	1	0
ZNF662	389114	broad.mit.edu	37	3	42955892	42955892	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:42955892G>T	ENST00000541208.1	+	5	696	c.327G>T	c.(325-327)atG>atT	p.M109I	ZNF662_ENST00000328199.6_Missense_Mutation_p.M135I|ZNF662_ENST00000422021.1_Intron|KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000440367.2_Missense_Mutation_p.M109I			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		AGGACCTCATGGTCCTATCAA	0.438000													16	24					5.03518e-11	7.1154e-11	0.557998	1	0
EIF2D	1939	broad.mit.edu	37	1	206772944	206772944	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:206772944C>A	ENST00000271764.2	-	10	1283	c.1075G>T	c.(1075-1077)Gag>Tag	p.E359*	EIF2D_ENST00000367114.3_Nonsense_Mutation_p.E235*	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	359					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						GGGGAGGGCTCGGGTATGACG	0.522000													16	53					0.000132079	0.000149316	0.575678	1	0
ATG9B	285973	broad.mit.edu	37	7	150721495	150721495	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:150721495C>A	ENST00000605938.1	-	1	91	c.16G>T	c.(16-18)Ggc>Tgc	p.G6C	ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000605952.1_Missense_Mutation_p.G6C|ATG9B_ENST00000377974.2_Missense_Mutation_p.G6C|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	6					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCCCCAGCCCATTCGGCTC	0.632000													4	8					0.00909568	0.00946462	0.150653	1	0
RRAGB	10325	broad.mit.edu	37	X	55757834	55757834	+	Silent	SNP	C	C	A	rs35893886		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:55757834C>A	ENST00000374941.4	+	5	920	c.331C>A	c.(331-333)Cgg>Agg	p.R111R	RRAGB_ENST00000474757.1_3'UTR|RRAGB_ENST00000262850.7_Silent_p.R139R	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	139					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						CACTAGCCAACGGGACAACAT	0.393000													8	30					5.50884e-06	6.50335e-06	0.411799	1	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057937	46057937	+	Silent	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:46057937C>G	ENST00000380095.1	+	1	665	c.603C>G	c.(601-603)acC>acG	p.T201T	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	201	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						GCAAGTCCACCTGCTGCGTGC	0.692000													21	185					0	0	0.693898	0	0
FLG	2312	broad.mit.edu	37	1	152286063	152286063	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:152286063G>T	ENST00000368799.1	-	3	1334	c.1299C>A	c.(1297-1299)gaC>gaA	p.D433E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	433	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGATTGTGTGTCTGAGTTTT	0.602000									Ichthyosis				137	193					1.324e-77	2.53039e-77	0.870114	1	0
NGF	4803	broad.mit.edu	37	1	115828972	115828972	+	Missense_Mutation	SNP	C	C	T	rs149823633		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:115828972C>T	ENST00000369512.2	-	3	613	c.445G>A	c.(445-447)Gcc>Acc	p.A149T	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	149					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	ATGTCTGTGGCGGTGGTCTTA	0.527000													48	128					0	0	0.870114	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7654166	7654166	+	Splice_Site	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:7654166G>C	ENST00000299492.4	+	12	1524		c.e12+1		PPFIBP2_ENST00000530181.1_Splice_Site|PPFIBP2_ENST00000528883.1_Splice_Site|PPFIBP2_ENST00000533792.1_Splice_Site|PPFIBP2_ENST00000530582.1_Splice_Site	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)						cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGGAAACCAGGTAAGAGGCCT	0.562000													7	29					0	0	0.307466	0	0
CHAT	1103	broad.mit.edu	37	10	50870702	50870702	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:50870702G>T	ENST00000395562.2	+	15	2074	c.1605G>T	c.(1603-1605)ggG>ggT	p.G535G	CHAT_ENST00000339797.1_Silent_p.G499G|CHAT_ENST00000351556.3_Silent_p.G499G|CHAT_ENST00000337653.2_Silent_p.G617G|CHAT_ENST00000395559.2_Silent_p.G499G|CHAT_ENST00000455728.2_Silent_p.G499G	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	617					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CCATAACAGGGATGGCCATTG	0.567000													13	105					3.27435e-08	4.2573e-08	0.457914	1	0
USH2A	7399	broad.mit.edu	37	1	215901512	215901512	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:215901512T>C	ENST00000366943.2	-	61	12312	c.11926A>G	c.(11926-11928)Acg>Gcg	p.T3976A	USH2A_ENST00000307340.3_Missense_Mutation_p.T3976A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3976	Fibronectin type-III 25.		T -> M (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGCACTCGTGGCTTGAGCC	0.502000										HNSCC(13;0.011)			53	43					0	0	0.870114	0	0
PLA2G7	7941	broad.mit.edu	37	6	46672318	46672318	+	Silent	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:46672318T>C	ENST00000274793.7	-	12	1501	c.1305A>G	c.(1303-1305)tcA>tcG	p.S435S	PLA2G7_ENST00000537365.1_Silent_p.S435S	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	435					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TCTCTATTCCTGAAGAGTTCT	0.353000													8	32					0	0	0.361761	0	0
INTS2	57508	broad.mit.edu	37	17	59967197	59967197	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:59967197T>C	ENST00000444766.3	-	15	2033	c.1958A>G	c.(1957-1959)tAc>tGc	p.Y653C	INTS2_ENST00000251334.6_Missense_Mutation_p.Y645C	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	653					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CAGTATATAGTAGAGCACCAA	0.388000													7	36					0	0	0.307466	0	0
WNT8A	7478	broad.mit.edu	37	5	137426298	137426298	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:137426298C>G	ENST00000506684.1	+	5	882	c.646C>G	c.(646-648)Ctg>Gtg	p.L216V	WNT8A_ENST00000398754.1_Missense_Mutation_p.L198V			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	198					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTGGCTGCAGCTGGCTGAATT	0.517000													5	30					0	0	0.217242	0	0
SLC12A3	6559	broad.mit.edu	37	16	56921836	56921836	+	Splice_Site	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:56921836G>A	ENST00000438926.2	+	18	2207		c.e18-1		SLC12A3_ENST00000566786.1_Splice_Site|SLC12A3_ENST00000563236.1_Splice_Site|SLC12A3_ENST00000262502.5_Splice_Site	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3						sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCCCCTGGCAGGCCGCAGGTC	0.577000													14	65					0	0	0.557998	0	0
CHRM2	1129	broad.mit.edu	37	7	136700299	136700299	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:136700299C>A	ENST00000445907.2	+	3	1215	c.687C>A	c.(685-687)gaC>gaA	p.D229E	CHRM2_ENST00000401861.1_Missense_Mutation_p.D229E|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.D229E|CHRM2_ENST00000320658.5_Missense_Mutation_p.D229E|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.D229E|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.D229E|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000586239.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	229					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCAACCAAGACCCCGTTTCTC	0.478000													5	11					0.000602214	0.000663929	0.184627	1	0
HELQ	113510	broad.mit.edu	37	4	84347187	84347187	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:84347187C>T	ENST00000295488.3	-	14	2897	c.2735G>A	c.(2734-2736)aGc>aAc	p.S912N	HELQ_ENST00000510985.1_Missense_Mutation_p.S845N	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	912							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CCCAATAAAGCTTTCAGAGAC	0.383000								Other identified genes with known or suspected DNA repair function					6	124					0	0	0.278610	0	0
FREM2	341640	broad.mit.edu	37	13	39451374	39451374	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:39451374G>A	ENST00000280481.7	+	21	8881	c.8665G>A	c.(8665-8667)Gca>Aca	p.A2889T		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2889					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTGCTTTTGCAGAAGGTAT	0.423000													35	250					0	0	0.853193	0	0
SDK1	221935	broad.mit.edu	37	7	4247759	4247759	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:4247759A>T	ENST00000404826.2	+	37	5382	c.5243A>T	c.(5242-5244)aAc>aTc	p.N1748I	SDK1_ENST00000389531.3_Missense_Mutation_p.N1728I	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1748	Fibronectin type-III 11.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACAGCCAGAACGAAACGGAG	0.552000													22	105					0	0	0.639603	0	0
HTATSF1	27336	broad.mit.edu	37	X	135581828	135581828	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:135581828C>A	ENST00000535601.1	+	3	680	c.258C>A	c.(256-258)acC>acA	p.T86T	HTATSF1_ENST00000218364.4_Silent_p.T86T	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	86					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					CTAGTTCTACCGCAAATGTTG	0.453000													54	140					2.89935e-36	5.38682e-36	0.870114	1	0
CFH	3075	broad.mit.edu	37	1	196659215	196659215	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:196659215G>T	ENST00000367429.4	+	9	1422	c.1182G>T	c.(1180-1182)ttG>ttT	p.L394F	CFH_ENST00000439155.2_Missense_Mutation_p.L394F|CFH_ENST00000359637.2_Missense_Mutation_p.L330F	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	394	Sushi 7.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TTCCTTATTTGGAAAATGGAT	0.313000													9	11					0.000978159	0.00106607	0.387290	1	0
NUP210	23225	broad.mit.edu	37	3	13432718	13432718	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:13432718C>T	ENST00000254508.5	-	4	608	c.526G>A	c.(526-528)Gcg>Acg	p.A176T		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	176					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TACCGCAGCGCATTGTGGGAG	0.597000													6	22					0	0	0.248553	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869461	22869461	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:22869461G>C	ENST00000302097.3	-	2	746	c.494C>G	c.(493-495)tCa>tGa	p.S165*		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AAGTCGCTTTGAATCAGGAGA	0.478000													29	75					0	0	0.750413	0	0
GJA10	84694	broad.mit.edu	37	6	90604527	90604527	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:90604527C>T	ENST00000369352.1	+	1	340	c.340C>T	c.(340-342)Ctt>Ttt	p.L114F		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	114					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		AAAGTCACACCTTAGAGCCCA	0.458000													12	15					0	0	0.435327	0	0
OR10C1	442194	broad.mit.edu	37	6	29407862	29407862	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:29407862G>T	ENST00000444197.2	+	1	780	c.70G>T	c.(70-72)Ggc>Tgc	p.G24C	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G24N(1)|p.G24S(1)		NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CGACCTCCAGGGCTTGCTCTT	0.542000													26	96					5.77227e-19	9.62526e-19	0.729181	1	0
OR6M1	390261	broad.mit.edu	37	11	123676119	123676119	+	Silent	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:123676119A>C	ENST00000309154.2	-	1	976	c.939T>G	c.(937-939)acT>acG	p.T313T		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		ACCAGTGTCAAGTTTTCCTTT	0.358000													52	114					0	0	0.870114	0	0
FGD1	2245	broad.mit.edu	37	X	54496846	54496846	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:54496846C>A	ENST00000375135.3	-	4	1437	c.704G>T	c.(703-705)aGc>aTc	p.S235I		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	235	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GGGACCTGGGCTGGGGCCAGG	0.637000													10	37					0.000308642	0.00034368	0.479597	1	0
HTATSF1	27336	broad.mit.edu	37	X	135592994	135592994	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:135592994G>T	ENST00000535601.1	+	10	1512	c.1090G>T	c.(1090-1092)Gaa>Taa	p.E364*	HTATSF1_ENST00000218364.4_Nonsense_Mutation_p.E364*	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	364					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					AGAAAGGGAGGAAAGGCTGAG	0.473000													13	55					1.5842e-08	2.08826e-08	0.435327	1	0
SRPX2	27286	broad.mit.edu	37	X	99921852	99921852	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:99921852G>C	ENST00000373004.3	+	8	1311	c.883G>C	c.(883-885)Ggt>Cgt	p.G295R		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	295	Sushi 3.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						CTGTGATGGCGGTTATGATCG	0.607000													34	56					0	0	0.760397	0	0
MED12L	116931	broad.mit.edu	37	3	150908657	150908657	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:150908657G>A	ENST00000474524.1	+	13	1945	c.1907G>A	c.(1906-1908)cGg>cAg	p.R636Q	MED12L_ENST00000422248.2_Missense_Mutation_p.R636Q|MED12L_ENST00000273432.4_Missense_Mutation_p.R496Q|MED12L_ENST00000309237.4_Missense_Mutation_p.R636Q	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	636					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTCGGCCGCGGTCACCAGTA	0.502000													9	58					0	0	0.457914	0	0
IMPG1	3617	broad.mit.edu	37	6	76751681	76751681	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:76751681C>A	ENST00000369950.3	-	2	419	c.230G>T	c.(229-231)gGg>gTg	p.G77V	IMPG1_ENST00000369963.3_Intron	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	77					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GACTTTAACCCCCGTTGGGAA	0.373000													22	51					7.07758e-08	9.14873e-08	0.681144	1	0
PTGS1	5742	broad.mit.edu	37	9	125145944	125145944	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:125145944G>A	ENST00000362012.2	+	8	924	c.919G>A	c.(919-921)Gag>Aag	p.E307K	PTGS1_ENST00000223423.4_Missense_Mutation_p.E307K|PTGS1_ENST00000540753.1_Missense_Mutation_p.E282K|PTGS1_ENST00000373698.5_Missense_Mutation_p.E198K	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	307					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CTGGCTACGTGAGCACAACCG	0.627000													10	71					0	0	0.361761	0	0
TAS1R2	80834	broad.mit.edu	37	1	19180711	19180711	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:19180711C>T	ENST00000375371.3	-	3	1274	c.1253G>A	c.(1252-1254)tGg>tAg	p.W418*	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	418					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCTCACCTGCCAGGGGTAGAC	0.602000													3	20					0	0	0.115264	0	0
CCDC132	55610	broad.mit.edu	37	7	92938167	92938167	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:92938167A>T	ENST00000544910.1	+	20	1791	c.1571A>T	c.(1570-1572)tAt>tTt	p.Y524F	CCDC132_ENST00000305866.5_Missense_Mutation_p.Y554F|CCDC132_ENST00000317751.6_Missense_Mutation_p.Y285F|CCDC132_ENST00000535481.1_Missense_Mutation_p.Y274F|CCDC132_ENST00000541136.1_Missense_Mutation_p.Y365F	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	554										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AAGAGTGCCTATCAAGAGTAT	0.408000													7	40					0	0	0.248553	0	0
LRRC23	10233	broad.mit.edu	37	12	7015772	7015772	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:7015772A>G	ENST00000007969.8	+	4	656	c.436A>G	c.(436-438)Att>Gtt	p.I146V	LRRC23_ENST00000429740.1_Missense_Mutation_p.I146V|LRRC23_ENST00000443597.2_Missense_Mutation_p.I146V|LRRC23_ENST00000323702.5_Missense_Mutation_p.I146V|LRRC23_ENST00000433346.1_Missense_Mutation_p.I146V|LRRC23_ENST00000436789.1_Missense_Mutation_p.I146V	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	146										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						TTATAACCAGATTACTGACAC	0.493000													76	140					0	0	0.870114	0	0
BAGE2	85319	broad.mit.edu	37	21	11049598	11049598	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:11049598C>A	ENST00000470054.1	-	0	510									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTGTCGCACACTGCACAGTTT	0.373000													8	194					0.00244969	0.00263115	0.457914	1	0
MUC16	94025	broad.mit.edu	37	19	9089803	9089803	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:9089803G>C	ENST00000397910.4	-	1	2215	c.2012C>G	c.(2011-2013)tCa>tGa	p.S671*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	671	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATTGTATATGATGGCTTTGT	0.522000													28	96					0	0	0.760397	0	0
AMPD1	270	broad.mit.edu	37	1	115216274	115216274	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:115216274C>T	ENST00000369538.3	-	14	2205	c.2158G>A	c.(2158-2160)Gga>Aga	p.G720R	AMPD1_ENST00000353928.6_Missense_Mutation_p.G691R|AMPD1_ENST00000520113.2_Missense_Mutation_p.G724R	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	691					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TGAGAAATTCCACACTGCAAG	0.453000													5	61					0	0	0.217242	0	0
MGA	23269	broad.mit.edu	37	15	42005391	42005391	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:42005391C>T	ENST00000219905.7	+	9	3308	c.3127C>T	c.(3127-3129)Cga>Tga	p.R1043*	MGA_ENST00000566586.1_Nonsense_Mutation_p.R1043*|MGA_ENST00000545763.1_Nonsense_Mutation_p.R1043*|MGA_ENST00000570161.1_Nonsense_Mutation_p.R1043*|MGA_ENST00000389936.4_Nonsense_Mutation_p.R1043*	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1043						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CATAAGGAAACGAGCCCCTCC	0.488000													39	54					0	0	0.847076	0	0
MAP2	4133	broad.mit.edu	37	2	210574870	210574870	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:210574870G>C	ENST00000360351.4	+	12	5471	c.4965G>C	c.(4963-4965)gcG>gcC	p.A1655A	MAP2_ENST00000392194.1_Silent_p.A299A|MAP2_ENST00000447185.1_Silent_p.A1651A|MAP2_ENST00000475600.1_3'UTR|MAP2_ENST00000199940.6_Silent_p.A356A|MAP2_ENST00000361559.4_Silent_p.A299A	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1655				A -> GL (in Ref. 2; AAB48098/AAB48097).	central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATCTCCTGCGACTCCCAAGC	0.502000													5	35					0	0	0.217242	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596479	58596479	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:58596479G>T	ENST00000240727.6	-	7	1505	c.1106C>A	c.(1105-1107)aCc>aAc	p.T369N	ZSCAN18_ENST00000600404.1_Missense_Mutation_p.T425N|ZSCAN18_ENST00000421612.2_Missense_Mutation_p.T233N|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.T369N	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	369					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGGCCTCTTGGTTCCCAGTTT	0.721000													5	23					1.23904e-05	1.4423e-05	0.184627	1	0
GTPBP1	9567	broad.mit.edu	37	22	39123339	39123339	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:39123339G>T	ENST00000216044.5	+	9	1756	c.1523G>T	c.(1522-1524)cGc>cTc	p.R508L		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	508					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					ATTAGCCCGCGCTACCAGGCC	0.607000													40	41					6.68952e-21	1.14998e-20	0.864702	1	0
EPHA3	2042	broad.mit.edu	37	3	89259220	89259220	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:89259220C>A	ENST00000336596.2	+	3	589	c.364C>A	c.(364-366)Ctg>Atg	p.L122M	EPHA3_ENST00000494014.1_Missense_Mutation_p.L122M|EPHA3_ENST00000452448.2_Missense_Mutation_p.L122M	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	122						extracellular region|integral to plasma membrane	ATP binding	p.L122M(2)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GACATTCAACCTGTACTACAT	0.413000										TSP Lung(6;0.00050)			37	130					1.30091e-30	2.37728e-30	0.827153	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768676	31768676	+	Silent	SNP	G	G	T	rs143305127		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:31768676G>T	ENST00000240587.4	-	2	2350	c.2023C>A	c.(2023-2025)Cgg>Agg	p.R675R		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	675					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CACCCATCCCGCGGGGGGCTG	0.652000													17	47					3.99206e-14	6.03787e-14	0.557998	1	0
MTMR8	55613	broad.mit.edu	37	X	63579329	63579329	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:63579329G>T	ENST00000374852.3	-	2	170	c.103C>A	c.(103-105)Ctg>Atg	p.L35M	MTMR8_ENST00000453546.1_Missense_Mutation_p.L35M	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	35						nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						ACATAGATCAGGTGGGTTGCA	0.408000													11	38					2.68362e-12	3.91679e-12	0.411799	1	0
ERBB4	2066	broad.mit.edu	37	2	212589920	212589920	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:212589920C>A	ENST00000342788.4	-	6	933		c.e6-1		ERBB4_ENST00000436443.1_Splice_Site|ERBB4_ENST00000484474.1_Splice_Site|ERBB4_ENST00000402597.1_Splice_Site	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4						cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTCCTTGTCACTGCAGAAGAC	0.507000										TSP Lung(8;0.080)			32	68					6.53348e-20	1.10605e-19	0.788014	1	0
CPAMD8	27151	broad.mit.edu	37	19	17014426	17014426	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:17014426C>A	ENST00000443236.1	-	34	4587	c.4556G>T	c.(4555-4557)aGc>aTc	p.S1519I		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1472						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CGTGGGGAGGCTGGGGATCTG	0.627000													53	173					4.33383e-22	7.58705e-22	0.870114	1	0
TRAJ26	28729	broad.mit.edu	37	14	22987466	22987466	+	RNA	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:22987466G>T	ENST00000390511.1	+	0	43																											CCCGGAACCAGATTGTCCGTG	0.522000													30	148					6.2361e-21	1.0748e-20	0.834066	1	0
TIAM1	7074	broad.mit.edu	37	21	32639019	32639019	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:32639019C>A	ENST00000286827.3	-	5	741	c.270G>T	c.(268-270)tgG>tgT	p.W90C	TIAM1_ENST00000541036.1_Missense_Mutation_p.W90C|TIAM1_ENST00000469412.1_Intron	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	90					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTCGGTCCACCCAGATGGGGC	0.592000													8	87					0.00621372	0.00655783	0.335167	1	0
TSPAN17	26262	broad.mit.edu	37	5	176078790	176078790	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:176078790G>T	ENST00000405525.2	+	3	403	c.174G>T	c.(172-174)ctG>ctT	p.L58L	TSPAN17_ENST00000298564.10_Intron|TSPAN17_ENST00000503045.1_Silent_p.L58L|TSPAN17_ENST00000508164.1_Silent_p.L58L|TSPAN17_ENST00000515708.1_Silent_p.L58L|TSPAN17_ENST00000310032.8_Silent_p.L58L	NM_001006616.2	NP_001006617.2	Q96FV3	TSN17_HUMAN	tetraspanin 17	58						integral to membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	13	all_cancers(89;0.00141)|Renal(175;0.000269)|Lung NSC(126;0.00814)|all_lung(126;0.0133)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGACAGATCTGGGAGGCCTTG	0.627000													32	96					3.62531e-18	6.0002e-18	0.796494	1	0
H3F3C	440093	broad.mit.edu	37	12	31945027	31945027	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:31945027G>A	ENST00000340398.3	-	1	148	c.74C>T	c.(73-75)gCt>gTt	p.A25V		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	25					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						TTTCCTGGCAGCTTTCGTGGC	0.577000										HNSCC(67;0.2)			44	39					0	0	0.870114	0	0
STIM2	57620	broad.mit.edu	37	4	27024376	27024376	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:27024376G>T	ENST00000382009.3	+	13	2551	c.2284G>T	c.(2284-2286)Gca>Tca	p.A762S	STIM2_ENST00000465503.1_Missense_Mutation_p.A675S|STIM2_ENST00000467011.1_3'UTR|STIM2_ENST00000412829.2_3'UTR|STIM2_ENST00000467087.1_Missense_Mutation_p.A667S|STIM2_ENST00000237364.5_Missense_Mutation_p.A754S	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	667					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				CTTCAGTCCTGCAAGCAAAGT	0.502000													17	116					6.33239e-15	9.89157e-15	0.592651	1	0
WDR13	64743	broad.mit.edu	37	X	48460215	48460215	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:48460215C>A	ENST00000218056.5	+	6	1380	c.875C>A	c.(874-876)aCa>aAa	p.T292K		NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	292						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						AACATCTCCACAGGCAAGAAA	0.592000													24	52					5.61819e-17	9.16218e-17	0.693898	1	0
GLIS3	169792	broad.mit.edu	37	9	3829319	3829319	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:3829319C>A	ENST00000324333.10	-	9	2375	c.2182G>T	c.(2182-2184)Ggc>Tgc	p.G728C	GLIS3_ENST00000381971.3_Missense_Mutation_p.G883C|GLIS3_ENST00000461870.1_5'UTR	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	728					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		CCTGTAATGCCCGAGTGAGTC	0.557000													8	30					0.00448238	0.00475318	0.307466	1	0
SYNE1	23345	broad.mit.edu	37	6	152771778	152771778	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:152771778C>A	ENST00000367255.5	-	27	3978	c.3377G>T	c.(3376-3378)tGg>tTg	p.W1126L	SYNE1_ENST00000413186.2_Missense_Mutation_p.W1126L|SYNE1_ENST00000367248.3_Missense_Mutation_p.W1116L|SYNE1_ENST00000341594.5_Missense_Mutation_p.W1192L|SYNE1_ENST00000448038.1_Missense_Mutation_p.W1133L|SYNE1_ENST00000423061.1_Missense_Mutation_p.W1133L|SYNE1_ENST00000265368.4_Missense_Mutation_p.W1126L|SYNE1_ENST00000367253.4_Missense_Mutation_p.W1126L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1126					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTAGTCCTTCCACTTGTCTGG	0.483000										HNSCC(10;0.0054)			43	125					1.07234e-20	1.8387e-20	0.870114	1	0
ASIC2	40	broad.mit.edu	37	17	31618867	31618867	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:31618867C>A	ENST00000225823.2	-	1	1139	c.267G>T	c.(265-267)tgG>tgT	p.W89C	ASIC2_ENST00000359872.6_Intron	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	45					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	AGGCCAGCACCCACAGCGCCC	0.697000													5	21					0.217242	0.219546	0.217242	1	0
CCDC33	80125	broad.mit.edu	37	15	74610981	74610981	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:74610981C>A	ENST00000268082.4	+	1	71	c.51C>A	c.(49-51)ggC>ggA	p.G17G	CCDC33_ENST00000321288.5_Intron|CCDC33_ENST00000558821.1_Silent_p.G17G|CCDC33_ENST00000398814.3_Intron			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	0							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTGCCCCAGGCCTCATTGACA	0.637000													10	12					4.3838e-07	5.46541e-07	0.435327	1	0
IKBKAP	8518	broad.mit.edu	37	9	111662599	111662599	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:111662599C>A	ENST00000374647.5	-	19	2378	c.2071G>T	c.(2071-2073)Gtg>Ttg	p.V691L	IKBKAP_ENST00000537196.1_Missense_Mutation_p.V342L	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	691					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CCCCTCTCCACTTTCCGCAGA	0.453000													20	63					1.85244e-09	2.50117e-09	0.654019	1	0
DGKK	139189	broad.mit.edu	37	X	50122676	50122676	+	RNA	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:50122676A>T	ENST00000376025.2	-	0	2870							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CATAGCTGGTAATGTTGAGCA	0.458000													28	96					0	0	0.819951	0	0
POTEG	404785	broad.mit.edu	37	14	19553542	19553542	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:19553542C>A	ENST00000409832.3	+	1	178	c.126C>A	c.(124-126)aaC>aaA	p.N42K		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	42								p.N42K(1)		cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GCAAGAGCAACGTGGGCACTT	0.607000													21	581					4.00102e-26	7.15464e-26	0.819951	1	0
KRT1	3848	broad.mit.edu	37	12	53070085	53070085	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:53070085C>A	ENST00000252244.3	-	7	1507	c.1449G>T	c.(1447-1449)agG>agT	p.R483S		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	483	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CCAGGAGGGTCCTGTAGGTGG	0.572000													23	31					1.06647e-15	1.70176e-15	0.788014	1	0
SNTG1	54212	broad.mit.edu	37	8	51617212	51617212	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:51617212C>A	ENST00000522124.1	+	16	1752	c.1091C>A	c.(1090-1092)tCt>tAt	p.S364Y	SNTG1_ENST00000517473.1_Missense_Mutation_p.S364Y|SNTG1_ENST00000518864.1_Missense_Mutation_p.S364Y|SNTG1_ENST00000276467.5_Missense_Mutation_p.S364Y	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	364	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CAGTCTGAGTCTGGGGAGGAC	0.532000													16	140					8.00594e-06	9.41792e-06	0.557998	1	0
DMD	1756	broad.mit.edu	37	X	32328370	32328370	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:32328370C>T	ENST00000357033.4	-	42	6152	c.5946G>A	c.(5944-5946)atG>atA	p.M1982I	DMD_ENST00000378677.2_Missense_Mutation_p.M1978I	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1982					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCATCACCATCATCGTTTCTT	0.373000													14	30					0	0	0.539581	0	0
C9orf139	401563	broad.mit.edu	37	9	139927525	139927525	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:139927525C>T	ENST00000314330.2	+	2	1524	c.10C>T	c.(10-12)Cgg>Tgg	p.R4W		NM_207511.1	NP_997394.1	Q6ZV77	CI139_HUMAN	chromosome 9 open reading frame 139	4										cervix(1)|lung(2)	3	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		GATGGCCCTGCGGGGTCACCC	0.662000													14	92					0	0	0.479597	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741775	140741775	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140741775C>A	ENST00000522605.1	+	1	2073	c.2073C>A	c.(2071-2073)taC>taA	p.Y691*	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGTTTTACCTGGTTGTGG	0.587000													35	77					2.40228e-13	3.57661e-13	0.864702	1	0
CER1	9350	broad.mit.edu	37	9	14722638	14722638	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:14722638G>T	ENST00000380911.3	-	1	77	c.33C>A	c.(31-33)ctC>ctA	p.L11L		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	11					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CTAGAGGCAGGAGTACCAGCA	0.532000													12	60					1.52009e-12	2.23326e-12	0.479597	1	0
TPTE	7179	broad.mit.edu	37	21	10943001	10943001	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:10943001G>T	ENST00000298232.7	-	11	899	c.532C>A	c.(532-534)Ctt>Att	p.L178I	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.L196I|TPTE_ENST00000342420.5_Missense_Mutation_p.L158I	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	196					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGTCGTAGAAGTCGAAGTAAA	0.318000													3	35					6.4e-05	7.34895e-05	0.115264	1	0
PLCL2	23228	broad.mit.edu	37	3	17056272	17056272	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:17056272G>A	ENST00000418129.2	+	3	2974	c.2509G>A	c.(2509-2511)Gtg>Atg	p.V837M	PLCL2_ENST00000432376.1_Missense_Mutation_p.V837M|PLCL2_ENST00000396755.2_Missense_Mutation_p.V837M	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	963	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						CATGTTGGCGGTGTCTCCCCG	0.542000													51	206					0	0	0.870114	0	0
FAM47C	442444	broad.mit.edu	37	X	37026699	37026699	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37026699C>A	ENST00000358047.3	+	1	268	c.216C>A	c.(214-216)cgC>cgA	p.R72R		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	72										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TTGTTTGTCGCCGTGACGAGT	0.532000													17	84					3.99206e-14	6.03787e-14	0.557998	1	0
NARS2	79731	broad.mit.edu	37	11	78154805	78154805	+	Splice_Site	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:78154805C>G	ENST00000281038.5	-	12	1540		c.e12-1		RP11-452H21.1_ENST00000534168.1_RNA|NARS2_ENST00000528850.1_Splice_Site	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)						asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CAGCAGCAACCTAAGGAAAAA	0.398000													3	33					0	0	0.115264	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890474	2890474	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:2890474C>T	ENST00000380698.4	-	7	1143	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	352					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				AAAGGGTGGTCAGCACAGAAC	0.537000													12	37					0	0	0.435327	0	0
MMP10	4319	broad.mit.edu	37	11	102647123	102647123	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:102647123C>A	ENST00000279441.4	-	6	856	c.820G>T	c.(820-822)Gtg>Ttg	p.V274L		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	274					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TTTGTGGGCACCAGGGGTTCC	0.478000													20	56					4.54149e-19	7.61098e-19	0.624587	1	0
DSG3	1830	broad.mit.edu	37	18	29041195	29041195	+	Silent	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:29041195A>G	ENST00000257189.4	+	8	902	c.819A>G	c.(817-819)tcA>tcG	p.S273S		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	273	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCAGTATTCAGCACGTATTG	0.313000													7	9					0	0	0.278610	0	0
ZNF667	63934	broad.mit.edu	37	19	56972076	56972076	+	Silent	SNP	G	G	T	rs139557092		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:56972076G>T	ENST00000591790.1	-	3	1570	c.142C>A	c.(142-144)Cgg>Agg	p.R48R	ZNF667_ENST00000292069.6_Silent_p.R48R|ZNF667_ENST00000504904.3_Silent_p.R48R|ZNF667_ENST00000342634.3_Silent_p.R141R			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ACCAGGTTCCGGTAATTCTCC	0.498000													21	83					3.00307e-07	3.78647e-07	0.729181	1	0
BCORL1	63035	broad.mit.edu	37	X	129149884	129149884	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:129149884C>A	ENST00000540052.1	+	3	3180	c.3136C>A	c.(3136-3138)Ctg>Atg	p.L1046M	BCORL1_ENST00000359304.2_Missense_Mutation_p.L1046M|BCORL1_ENST00000218147.7_Missense_Mutation_p.L1046M|BCORL1_ENST00000303743.5_Missense_Mutation_p.L1046M	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1046					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CCAGGTGGATCTGGGGCGAGT	0.597000													34	48					1.36615e-20	2.32454e-20	0.769981	1	0
MS4A12	54860	broad.mit.edu	37	11	60268520	60268520	+	Silent	SNP	G	G	C	rs140200568		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:60268520G>C	ENST00000016913.4	+	3	336	c.279G>C	c.(277-279)gtG>gtC	p.V93V	MS4A12_ENST00000537076.1_Intron	NM_017716.2	NP_060186.2	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member 12	93						integral to membrane	receptor activity			breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						TTTTTCAGGTGATCCAGATCA	0.353000													53	199					0	0	0.870114	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871044	51871044	+	Missense_Mutation	SNP	C	C	G	rs61758128	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:51871044C>G	ENST00000371497.5	+	2	1934	c.1047C>G	c.(1045-1047)aaC>aaG	p.N349K	TSHZ2_ENST00000329613.6_Missense_Mutation_p.N346K|TSHZ2_ENST00000603338.2_Missense_Mutation_p.N346K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	349					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CTCAGAAGAACGCCAACTTGC	0.498000													6	87					0	0	0.217242	0	0
CDH12	1010	broad.mit.edu	37	5	21760733	21760733	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:21760733G>T	ENST00000382254.1	-	13	2653	c.1567C>A	c.(1567-1569)Caa>Aaa	p.Q523K	RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000522262.1_Missense_Mutation_p.Q483K|CDH12_ENST00000504376.2_Missense_Mutation_p.Q523K|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	523	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AAGGAGAATTGTTGCCCAGCA	0.393000										HNSCC(59;0.17)			101	116					2.13259e-42	3.98442e-42	0.870114	1	0
SERPINA9	327657	broad.mit.edu	37	14	94936049	94936049	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:94936049C>A	ENST00000337425.5	-	2	257	c.183G>T	c.(181-183)caG>caT	p.Q61H	SERPINA9_ENST00000298845.7_Missense_Mutation_p.Q61H|SERPINA9_ENST00000546329.1_Intron|SERPINA9_ENST00000424550.2_Intron|SERPINA9_ENST00000380365.3_Missense_Mutation_p.Q43H|SERPINA9_ENST00000448305.2_Intron	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	43					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGGAATACACCTGTGAGGCAG	0.577000													18	59					3.85864e-22	6.77293e-22	0.639603	1	0
DSG3	1830	broad.mit.edu	37	18	29041194	29041194	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:29041194C>A	ENST00000257189.4	+	8	901	c.818C>A	c.(817-819)tCa>tAa	p.S273*		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	273	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTTCAGTATTCAGCACGTATT	0.313000													7	9					0.000157383	0.000176428	0.278610	1	0
NUAK1	9891	broad.mit.edu	37	12	106460879	106460879	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:106460879G>A	ENST00000261402.2	-	7	3066	c.1687C>T	c.(1687-1689)Cgg>Tgg	p.R563W		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	563							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						CTGTAGCTCCGGGAGAGGCCC	0.612000													12	33					0	0	0.435327	0	0
ALPK2	115701	broad.mit.edu	37	18	56203487	56203487	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr18:56203487C>A	ENST00000361673.3	-	5	4145	c.3932G>T	c.(3931-3933)aGa>aTa	p.R1311I	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1311							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATGGCTTTCTCTGCTATCAGC	0.527000													27	37					4.62619e-21	8.01472e-21	0.796494	1	0
S100Z	170591	broad.mit.edu	37	5	76171232	76171232	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:76171232C>A	ENST00000317593.4	+	3	280	c.48C>A	c.(46-48)ttC>ttA	p.F16L	S100Z_ENST00000513010.1_Missense_Mutation_p.F16L	NM_130772.3	NP_570128.2	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	16	EF-hand 1.						calcium ion binding			large_intestine(1)|ovary(1)	2		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		TTAGAATCTTCCACCGCTATT	0.557000													7	41					0.0381472	0.0392657	0.278610	1	0
NPFFR2	10886	broad.mit.edu	37	4	72994591	72994591	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:72994591G>T	ENST00000308744.6	+	2	687	c.589G>T	c.(589-591)Ggc>Tgc	p.G197C	NPFFR2_ENST00000344413.5_Intron|NPFFR2_ENST00000395999.1_Missense_Mutation_p.G98C|NPFFR2_ENST00000358749.3_Missense_Mutation_p.G95C	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	197					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity	p.G197S(2)		NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTTACTAGTTGGCATATTCTG	0.358000													22	141					3.73148e-12	5.41064e-12	0.717897	1	0
RANBP1	5902	broad.mit.edu	37	22	20109804	20109804	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:20109804G>A	ENST00000402752.1	+	3	396	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	RANBP1_ENST00000430524.1_5'UTR|RANBP1_ENST00000331821.3_Missense_Mutation_p.R57Q	NM_001278640.1	NP_001265569.1	P43487	RANG_HUMAN	RAN binding protein 1	57	RanBD1.				intracellular transport|signal transduction|viral reproduction	nuclear envelope	GDP-dissociation inhibitor activity|GTPase activator activity|Ran GTPase binding			breast(1)|large_intestine(1)|lung(1)|ovary(1)	4	Colorectal(54;0.0993)					AAACTGTTCCGATTTGCCTCT	0.577000													9	86					0	0	0.387290	0	0
CLSPN	63967	broad.mit.edu	37	1	36212457	36212457	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:36212457G>C	ENST00000251195.5	-	15	2860	c.2764C>G	c.(2764-2766)Cag>Gag	p.Q922E	CLSPN_ENST00000318121.3_Missense_Mutation_p.Q922E|CLSPN_ENST00000520551.1_Missense_Mutation_p.Q869E|CLSPN_ENST00000373220.3_Missense_Mutation_p.Q858E			Q9HAW4	CLSPN_HUMAN	claspin	922					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTTTCAGCCTGAGATGTGAAC	0.438000													9	86					0	0	0.335167	0	0
FAM129C	199786	broad.mit.edu	37	19	17654393	17654393	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:17654393A>G	ENST00000335393.4	+	13	1738	c.1600A>G	c.(1600-1602)Atc>Gtc	p.I534V	FAM129C_ENST00000600871.1_Missense_Mutation_p.I480V|FAM129C_ENST00000599124.1_Intron|FAM129C_ENST00000449408.2_Missense_Mutation_p.I260V|FAM129C_ENST00000599164.1_Missense_Mutation_p.I503V|FAM129C_ENST00000601861.1_Missense_Mutation_p.I503V|FAM129C_ENST00000595684.1_Missense_Mutation_p.I534V|FAM129C_ENST00000352727.3_Intron|FAM129C_ENST00000332386.5_Missense_Mutation_p.I534V|FAM129C_ENST00000300971.2_Missense_Mutation_p.I534V	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	534										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						GGGTCTCTGCATCTTTTTACC	0.537000													9	31					0	0	0.387290	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174862	140174862	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:140174862C>A	ENST00000526136.1	+	1	313	c.313C>A	c.(313-315)Cac>Aac	p.H105N	PCDHA2_ENST00000520672.2_Missense_Mutation_p.H105N|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.H105N	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTAGCATCCACGTGGAGGT	0.532000													32	194					4.65686e-17	7.61306e-17	0.788014	1	0
NCOA1	8648	broad.mit.edu	37	2	24929734	24929734	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:24929734T>A	ENST00000405141.1	+	14	2106	c.1395T>A	c.(1393-1395)agT>agA	p.S465R	NCOA1_ENST00000407230.1_Missense_Mutation_p.S314R|NCOA1_ENST00000395856.3_Missense_Mutation_p.S465R|NCOA1_ENST00000406961.1_Missense_Mutation_p.S465R|NCOA1_ENST00000348332.3_Missense_Mutation_p.S465R|NCOA1_ENST00000538539.1_Missense_Mutation_p.S465R|NCOA1_ENST00000288599.5_Missense_Mutation_p.S465R			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	465	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACAGAGCAGTAATCCCTCTT	0.453000			T	PAX3	alveolar rhadomyosarcoma								27	79					0	0	0.750413	0	0
SRD5A3	79644	broad.mit.edu	37	4	56225571	56225571	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:56225571C>T	ENST00000264228.4	+	2	508	c.280C>T	c.(280-282)Ctt>Ttt	p.L94F	SRD5A3_ENST00000514398.1_3'UTR	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	94					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GCTTTGGTGCCTTACTCAATC	0.483000													23	132					0	0	0.639603	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													4	162					0	0	0.150653	0	0
LRFN3	79414	broad.mit.edu	37	19	36435668	36435668	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:36435668G>T	ENST00000588831.1	+	4	2688	c.1634G>T	c.(1633-1635)gGc>gTc	p.G545V	LRFN3_ENST00000246529.3_Missense_Mutation_p.G545V			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	545					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCGCTGGGCGGCGTCATCGTA	0.687000													8	24					0.000274275	0.000305922	0.307466	1	0
NOP14	8602	broad.mit.edu	37	4	2943931	2943931	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:2943931G>C	ENST00000416614.2	-	14	2104	c.2039C>G	c.(2038-2040)gCc>gGc	p.A680G	NOP14-AS1_ENST00000505731.1_RNA|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000507702.1_RNA|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000502735.1_Missense_Mutation_p.A680G|NOP14_ENST00000314262.6_Missense_Mutation_p.A680G|NOP14_ENST00000398071.4_Missense_Mutation_p.A680G			P78316	NOP14_HUMAN	NOP14 nucleolar protein	680					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						GATGTGATTGGCCTCTGTCGA	0.622000													15	56					0	0	0.520397	0	0
OPN5	221391	broad.mit.edu	37	6	47749820	47749820	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:47749820T>A	ENST00000489301.2	+	1	103	c.18T>A	c.(16-18)acT>acA	p.T6T	OPN5_ENST00000393699.2_Silent_p.T6T|OPN5_ENST00000371211.2_Silent_p.T6T			Q6U736	OPN5_HUMAN	opsin 5	6					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						TAAATCACACTGCCCTGCCTC	0.498000													17	42					0	0	0.592651	0	0
CPZ	8532	broad.mit.edu	37	4	8605768	8605768	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:8605768C>A	ENST00000382480.2	+	4	951	c.151C>A	c.(151-153)Cac>Aac	p.H51N	CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000360986.4_Missense_Mutation_p.H188N|CPZ_ENST00000315782.6_Missense_Mutation_p.H177N	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	188	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CTTCAGCCACCACTCCTACGC	0.697000													9	30					6.40141e-05	7.34895e-05	0.387290	1	0
SHB	6461	broad.mit.edu	37	9	38016031	38016031	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:38016031T>C	ENST00000377707.3	-	2	1380	c.815A>G	c.(814-816)tAt>tGt	p.Y272C	RP11-613M10.9_ENST00000540557.1_Missense_Mutation_p.Y272C|SHB_ENST00000377700.4_Missense_Mutation_p.Y272C	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	272	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CTGTGCCTCATAGGGCTCCAT	0.557000													16	216					0	0	0.557998	0	0
WSCD1	23302	broad.mit.edu	37	17	5998460	5998460	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:5998460G>C	ENST00000574946.1	+	5	1156	c.766G>C	c.(766-768)Gag>Cag	p.E256Q	WSCD1_ENST00000317744.5_Missense_Mutation_p.E256Q|WSCD1_ENST00000574232.1_Missense_Mutation_p.E256Q|WSCD1_ENST00000573634.1_Missense_Mutation_p.E140Q|WSCD1_ENST00000539421.1_Missense_Mutation_p.E256Q			Q658N2	WSCD1_HUMAN	WSC domain containing 1	256	WSC 2.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						CCGACTGCCAGAGAACATCAC	0.562000													30	112					0	0	0.812448	0	0
CD101	9398	broad.mit.edu	37	1	117544468	117544468	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:117544468T>A	ENST00000256652.4	+	1	87	c.29T>A	c.(28-30)tTc>tAc	p.F10Y	CD101_ENST00000369470.1_Missense_Mutation_p.F10Y	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	10					cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GTGGCATCTTTCTTTCTCCTT	0.438000													12	88					0	0	0.411799	0	0
MTNR1B	4544	broad.mit.edu	37	11	92703026	92703026	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:92703026G>C	ENST00000257068.2	+	1	141	c.135G>C	c.(133-135)gcG>gcC	p.A45A		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	45					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CGCTGTCCGCGGTGCTCATCG	0.716000													7	22					0	0	0.335167	0	0
TRBV9	28586	broad.mit.edu	37	7	142239729	142239729	+	RNA	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:142239729C>T	ENST00000390363.2	-	0	197																											TACCAGTACACAGAGAGGTCT	0.507000													12	28					0	0	0.435327	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206690	142206690	+	RNA	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:142206690T>A	ENST00000426318.2	-	0	215																											CCAGGTCTTGTCGATACCAGA	0.493000													20	158					0	0	0.706142	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499707	104499707	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:104499707G>C	ENST00000361820.3	-	1	1155	c.555C>G	c.(553-555)tgC>tgG	p.C185W		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	185					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CCACGGTATGGCACACACTTT	0.602000													8	66					0	0	0.307466	0	0
DOCK10	55619	broad.mit.edu	37	2	225781421	225781421	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:225781421C>T	ENST00000409592.3	-	3	419	c.306G>A	c.(304-306)ctG>ctA	p.L102L	DOCK10_ENST00000258390.7_Silent_p.L108L|DOCK10_ENST00000474102.1_5'UTR			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	108							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCTCCTTAACCAGTAAATTTT	0.403000													4	13					0	0	0.150653	0	0
SOX7	83595	broad.mit.edu	37	8	10583327	10583327	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:10583327G>A	ENST00000304501.1	-	2	1166	c.1088C>T	c.(1087-1089)aCg>aTg	p.T363M	SOX7_ENST00000554914.1_Missense_Mutation_p.T415M|SOX7_ENST00000553390.1_Missense_Mutation_p.T415M	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	363	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		TGTGGGACCCGTTGGTGTCAC	0.607000													7	50					0	0	0.278610	0	0
KIAA1755	85449	broad.mit.edu	37	20	36842064	36842064	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr20:36842064G>C	ENST00000279024.4	-	14	3254	c.2983C>G	c.(2983-2985)Cag>Gag	p.Q995E		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	995										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				AGGCGGCGCTGGTCCCCAGGA	0.647000													5	12					0	0	0.217242	0	0
CASQ1	844	broad.mit.edu	37	1	160160607	160160607	+	Silent	SNP	G	G	T	rs146684787	by1000genomes	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:160160607G>T	ENST00000368079.3	+	1	323	c.48G>T	c.(46-48)ctG>ctT	p.L16L	CASQ1_ENST00000368078.3_Silent_p.L22L	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	22	Poly-Leu.					mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGCTGTTGCTGCTGGTGCTAG	0.597000													32	45					1.80694e-10	2.5214e-10	0.740014	1	0
ADH1C	126	broad.mit.edu	37	4	100268982	100268982	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:100268982C>A	ENST00000515683.1	-	0	391				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TCCCATAGCACAGCTGCTTTG	0.413000													4	52					2.0095e-06	2.42375e-06	0.248553	1	0
MAPK10	5602	broad.mit.edu	37	4	86985475	86985475	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:86985475C>T	ENST00000395169.3	-	11	1660	c.940G>A	c.(940-942)Gac>Aac	p.D314N	MAPK10_ENST00000395160.3_Missense_Mutation_p.D207N|MAPK10_ENST00000449047.2_Missense_Mutation_p.D207N|MAPK10_ENST00000395166.1_Missense_Mutation_p.D314N|MAPK10_ENST00000359221.3_Missense_Mutation_p.D352N|MAPK10_ENST00000361569.2_Missense_Mutation_p.D352N|MAPK10_ENST00000395161.2_Missense_Mutation_p.D352N|MAPK10_ENST00000395157.3_Missense_Mutation_p.D207N	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	352	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TGTAAGGCGTCGTCCACTGAT	0.438000													13	65					0	0	0.479597	0	0
SLC35E1	79939	broad.mit.edu	37	19	16666164	16666164	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:16666164G>A	ENST00000595753.1	-	5	818	c.801C>T	c.(799-801)gtC>gtT	p.V267V	CTD-3222D19.2_ENST00000409035.1_Intron	NM_024881.4	NP_079157.3	Q96K37	S35E1_HUMAN	solute carrier family 35, member E1	267					transport	integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(2)|ovary(1)	15						AGAAGCCGCTGACAGCCAGGA	0.572000													9	48					0	0	0.361761	0	0
KIF14	9928	broad.mit.edu	37	1	200567530	200567530	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:200567530T>A	ENST00000367350.4	-	14	2822	c.2384A>T	c.(2383-2385)cAa>cTa	p.Q795L		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	795					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						ATTGTCCATTTGAAACATAAT	0.303000													22	21					0	0	0.681144	0	0
SLC9A6	10479	broad.mit.edu	37	X	135081019	135081019	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:135081019A>G	ENST00000370695.4	+	5	720	c.685A>G	c.(685-687)Ata>Gta	p.I229V	SLC9A6_ENST00000370698.3_Missense_Mutation_p.I197V|SLC9A6_ENST00000370701.1_Missense_Mutation_p.I177V	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	197					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					GAACAGGTCAATAATGTATGG	0.353000													52	152					0	0	0.870114	0	0
GSR	2936	broad.mit.edu	37	8	30537159	30537159	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:30537159C>A	ENST00000221130.5	-	13	1537	c.1447G>T	c.(1447-1449)Ggg>Tgg	p.G483W	GSR_ENST00000541648.1_Missense_Mutation_p.G430W|GSR_ENST00000537535.1_Missense_Mutation_p.G401W|GSR_ENST00000414019.1_Missense_Mutation_p.G440W|GSR_ENST00000546342.1_Missense_Mutation_p.G454W	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	483					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TCATCACACCCAAGTCCCTGC	0.433000													21	55					1.39806e-14	2.15857e-14	0.729181	1	0
CHL1	10752	broad.mit.edu	37	3	361475	361475	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:361475C>A	ENST00000256509.2	+	3	658	c.16C>A	c.(16-18)Ctt>Att	p.L6I	CHL1_ENST00000397491.2_Missense_Mutation_p.L6I	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	6					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GCCGCTTTTACTTGGAAGAGG	0.373000													8	31					0.0692343	0.0710451	0.361761	1	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48873884	48873884	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:48873884C>T	ENST00000394754.1	+	8	2907	c.2793C>T	c.(2791-2793)atC>atT	p.I931I	GTF2A1L_ENST00000403751.3_Silent_p.I227I|STON1-GTF2A1L_ENST00000394751.3_Silent_p.I884I|STON1-GTF2A1L_ENST00000309827.2_Silent_p.I931I|STON1-GTF2A1L_ENST00000402114.2_Silent_p.I931I|GTF2A1L_ENST00000430487.2_Silent_p.I193I|LHCGR_ENST00000420913.3_Intron|STON1-GTF2A1L_ENST00000405008.1_Silent_p.I931I	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		884					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGCATAAAATCGTGCCTGAAG	0.413000													5	79					0	0	0.217242	0	0
IQGAP1	8826	broad.mit.edu	37	15	90931603	90931603	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:90931603G>A	ENST00000268182.5	+	1	154	c.30G>A	c.(28-30)ctG>ctA	p.L10L	IQGAP1_ENST00000560738.1_Silent_p.L10L	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	10					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTGACGGGCTGGGCGTGGCCC	0.692000													10	52					0	0	0.500413	0	0
EIF5A2	56648	broad.mit.edu	37	3	170612100	170612100	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:170612100T>A	ENST00000295822.2	-	4	568	c.383A>T	c.(382-384)aAt>aTt	p.N128I	EIF5A2_ENST00000460117.1_5'UTR|EIF5A2_ENST00000487522.1_Intron|EIF5A2_ENST00000474096.1_3'UTR	NM_020390.5	NP_065123.1	Q9GZV4	IF5A2_HUMAN	eukaryotic translation initiation factor 5A2	128					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	3	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)			TTCACCTGCATTGTATTTTCC	0.358000													33	92					0	0	0.859065	0	0
OGDHL	55753	broad.mit.edu	37	10	50944452	50944452	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:50944452C>A	ENST00000374103.4	-	21	2790	c.2705G>T	c.(2704-2706)cGg>cTg	p.R902L	OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000419399.1_Missense_Mutation_p.R845L|OGDHL_ENST00000432695.1_Missense_Mutation_p.R693L	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	902					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTGGCTGCTCCGCTCCTTCAC	0.617000													30	121					2.68265e-12	3.91679e-12	0.769981	1	0
SMC3	9126	broad.mit.edu	37	10	112350867	112350867	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:112350867G>C	ENST00000361804.4	+	17	1915	c.1789G>C	c.(1789-1791)Gat>Cat	p.D597H		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	597	Flexible hinge.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AGATGTCAGGGATACAGCCTA	0.343000													20	34					0	0	0.608945	0	0
GTF3C1	2975	broad.mit.edu	37	16	27544611	27544611	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:27544611C>A	ENST00000356183.4	-	5	865		c.e5+1		GTF3C1_ENST00000561623.1_Splice_Site	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa							transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCCAGGCTCACCAGCTCTTCC	0.552000													18	48					4.35082e-09	5.80399e-09	0.592651	1	0
COL14A1	7373	broad.mit.edu	37	8	121160097	121160097	+	Missense_Mutation	SNP	C	C	A	rs9642848		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:121160097C>A	ENST00000297848.3	+	2	286	c.16C>A	c.(16-18)Cgc>Agc	p.R6S	COL14A1_ENST00000309791.4_Missense_Mutation_p.R6S|COL14A1_ENST00000537875.1_Missense_Mutation_p.R6S|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.R6S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	6					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GATTTTCCAGCGCAAGATGCG	0.398000													4	22					0.0215528	0.0222534	0.217242	1	0
ZNF829	374899	broad.mit.edu	37	19	37405877	37405877	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:37405877G>T	ENST00000520965.1	-	3	395	c.329C>A	c.(328-330)gCa>gAa	p.A110E	ZNF829_ENST00000391711.3_Missense_Mutation_p.A29E	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTGGATACTGCTTGTAGAAG	0.403000													8	42					2.80697e-09	3.76711e-09	0.387290	1	0
NLGN4X	57502	broad.mit.edu	37	X	6069433	6069433	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:6069433G>A	ENST00000381095.3	-	2	702	c.75C>T	c.(73-75)gtC>gtT	p.V25V	NLGN4X_ENST00000381092.1_Silent_p.V25V|NLGN4X_ENST00000381093.2_Silent_p.V25V|NLGN4X_ENST00000275857.6_Silent_p.V25V|NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000538097.1_Silent_p.V25V	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	25					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						ACCACAGGAGGACATTGGAGT	0.493000													17	92					0	0	0.500413	0	0
GRM7	2917	broad.mit.edu	37	3	7348301	7348301	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:7348301G>T	ENST00000486284.1	+	4	1269	c.995G>T	c.(994-996)gGg>gTg	p.G332V	GRM7_ENST00000357716.4_Missense_Mutation_p.G332V|GRM7_ENST00000389336.4_Missense_Mutation_p.G332V|GRM7_ENST00000402647.2_Missense_Mutation_p.G332V|GRM7_ENST00000403881.1_Missense_Mutation_p.G332V	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	332					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	ATCGCAGAAGGGGCCATCACC	0.517000													14	70					3.41278e-10	4.72267e-10	0.520397	1	0
IRX4	50805	broad.mit.edu	37	5	1879631	1879631	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:1879631G>A	ENST00000505790.1	-	5	1179	c.723C>T	c.(721-723)agC>agT	p.S241S	IRX4_ENST00000231357.2_Silent_p.S241S|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000513692.1_Silent_p.S241S	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	241					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		CGTTCTTGGAGCTCTTGAGGG	0.687000													9	50					0	0	0.307466	0	0
EMILIN1	11117	broad.mit.edu	37	2	27301993	27301993	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:27301993G>T	ENST00000380320.4	+	1	559	c.60G>T	c.(58-60)ggG>ggT	p.G20G		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	20					cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCTGCAGGGGCCGCCAGCT	0.716000													11	16					4.3838e-07	5.46541e-07	0.435327	1	0
GK	2710	broad.mit.edu	37	X	30736712	30736712	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:30736712A>C	ENST00000378943.3	+	13	1194	c.1015A>C	c.(1015-1017)Ata>Cta	p.I339L	GK_ENST00000427190.1_Missense_Mutation_p.I140L|RP11-242C19.2_ENST00000497961.1_RNA|GK_ENST00000378946.3_Missense_Mutation_p.I345L|GK-AS1_ENST00000464659.1_RNA|GK_ENST00000378945.3_Missense_Mutation_p.I339L	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	345					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						TCTTGGAATTATAAAGACCTC	0.323000													17	32					0	0	0.681144	0	0
EMR1	2015	broad.mit.edu	37	19	6896492	6896492	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:6896492C>A	ENST00000312053.4	+	3	215	c.178C>A	c.(178-180)Caa>Aaa	p.Q60K	EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000450315.3_Missense_Mutation_p.Q60K|EMR1_ENST00000381404.4_Missense_Mutation_p.Q60K|EMR1_ENST00000250572.8_Missense_Mutation_p.Q60K|EMR1_ENST00000381407.5_Missense_Mutation_p.Q60K	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	60	EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CGCTTGCAAACAAGGCTTCCT	0.478000													22	78					1.10923e-09	1.50378e-09	0.639603	1	0
USP38	84640	broad.mit.edu	37	4	144141531	144141531	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:144141531C>T	ENST00000307017.4	+	10	3557	c.3051C>T	c.(3049-3051)aaC>aaT	p.N1017N		NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	1017					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					TTGATGACAACGACCCACCAG	0.478000													9	57					0	0	0.361761	0	0
SAMD4A	23034	broad.mit.edu	37	14	55251336	55251336	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:55251336G>T	ENST00000251091.5	+	10	2167	c.1862G>T	c.(1861-1863)gGa>gTa	p.G621V	SAMD4A_ENST00000554335.1_Missense_Mutation_p.G709V|SAMD4A_ENST00000555192.1_Missense_Mutation_p.G336V|SAMD4A_ENST00000392067.3_Missense_Mutation_p.G709V|SAMD4A_ENST00000357634.3_Missense_Mutation_p.G708V	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	709					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						CACGCCCTGGGAGGTGAGTGT	0.557000													28	147					8.16721e-17	1.32222e-16	0.750413	1	0
PCDH9	5101	broad.mit.edu	37	13	66878940	66878940	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:66878940G>T	ENST00000544246.1	-	5	4252	c.3561C>A	c.(3559-3561)agC>agA	p.S1187R	PCDH9_ENST00000328454.5_Missense_Mutation_p.S1153R|PCDH9_ENST00000456367.1_Missense_Mutation_p.S1153R|PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000377865.2_Missense_Mutation_p.S1187R	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1187					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GGTTCCTGTTGCTGTCTTCTT	0.488000													4	43					2.56e-06	3.07108e-06	0.150653	1	0
ZNF512	84450	broad.mit.edu	37	2	27839193	27839193	+	Splice_Site	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:27839193T>C	ENST00000355467.4	+	12	1379		c.e12+2		RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000556601.1_Splice_Site|ZNF512_ENST00000379717.1_Splice_Site|ZNF512_ENST00000416005.2_Splice_Site|ZNF512_ENST00000413371.2_Splice_Site			Q96ME7	ZN512_HUMAN	zinc finger protein 512						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					TGTACATTGGTTTGTAACTTT	0.398000													5	61					0	0	0.217242	0	0
RIC3	79608	broad.mit.edu	37	11	8161562	8161562	+	Silent	SNP	T	T	C	rs17852023		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:8161562T>C	ENST00000343202.4	-	2	368	c.303A>G	c.(301-303)ccA>ccG	p.P101P	RIC3_ENST00000335425.7_Intron|RIC3_ENST00000425599.2_Silent_p.P101P|RIC3_ENST00000539720.1_Silent_p.P52P|RIC3_ENST00000419822.2_Silent_p.P101P|RIC3_ENST00000309737.6_Silent_p.P101P	NM_001206671.2|NM_024557.4	NP_001193600.1|NP_078833.3	Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	101						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		AACCGTAGATTGGAATAATCT	0.403000													39	65					0	0	0.870114	0	0
OR1L4	254973	broad.mit.edu	37	9	125486959	125486959	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:125486959T>A	ENST00000259466.1	+	1	691	c.691T>A	c.(691-693)Tct>Act	p.S231T		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						CAGAATCCCCTCTGCAGCCGG	0.517000													16	275					0	0	0.520397	0	0
CORIN	10699	broad.mit.edu	37	4	47808993	47808993	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:47808993C>A	ENST00000273857.4	-	2	134	c.135G>T	c.(133-135)cgG>cgT	p.R45R	CORIN_ENST00000505909.1_Silent_p.R45R|CORIN_ENST00000502252.1_Silent_p.R45R|CORIN_ENST00000504584.1_Silent_p.R45R	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	45					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GCAATAGGAACCGGAGGAGGT	0.458000													10	33					0.00010058	0.000114093	0.411799	1	0
HOXC11	3227	broad.mit.edu	37	12	54367257	54367257	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:54367257G>T	ENST00000546378.1	+	1	348	c.232G>T	c.(232-234)Gag>Tag	p.E78*	HOTAIR_ENST00000424518.1_RNA|HOXC11_ENST00000243082.4_Nonsense_Mutation_p.E78*|HOTAIR_ENST00000455246.1_RNA			O43248	HXC11_HUMAN	homeobox C11	78					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						CTACGGCCTGGAGCCATCCGG	0.662000			T	NUP98	AML								88	91					9.79205e-48	1.86608e-47	0.870114	1	0
CLRN1	7401	broad.mit.edu	37	3	150690389	150690389	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:150690389G>T	ENST00000327047.1	-	1	397	c.107C>A	c.(106-108)gCc>gAc	p.A36D	CLRN1_ENST00000328863.4_Missense_Mutation_p.A36D|CLRN1-AS1_ENST00000476886.1_RNA|RP11-166N6.2_ENST00000469268.1_RNA	NM_174878.2	NP_777367.1	P58418	CLRN1_HUMAN	clarin 1	36					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GAGGACAGTGGCTTTGATCCA	0.522000													22	70					1.37878e-21	2.40745e-21	0.654019	1	0
ZCCHC12	170261	broad.mit.edu	37	X	117960349	117960349	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:117960349C>T	ENST00000310164.2	+	4	1649	c.1142C>T	c.(1141-1143)aCc>aTc	p.T381I		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						CAGGAGCTGACCCATACTGAG	0.507000													10	134					0	0	0.411799	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717818	142717818	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:142717818C>T	ENST00000381779.4	-	2	1332	c.1107G>A	c.(1105-1107)atG>atA	p.M369I	SLITRK4_ENST00000356928.1_Missense_Mutation_p.M369I|SLITRK4_ENST00000338017.4_Missense_Mutation_p.M369I	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	369	LRRNT.					integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTTCAGACATAGACTGTA	0.453000													39	173					0	0	0.834066	0	0
C5orf42	65250	broad.mit.edu	37	5	37169085	37169085	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:37169085C>A	ENST00000274258.7	-	34	7268	c.3681G>T	c.(3679-3681)ggG>ggT	p.G1227G	C5orf42_ENST00000425232.2_Silent_p.G2347G|C5orf42_ENST00000508244.1_Silent_p.G2347G			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2347										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TCTCAAGGGTCCCTGGCTTAA	0.383000													23	89					5.45024e-15	8.57384e-15	0.654019	1	0
TTC12	54970	broad.mit.edu	37	11	113230106	113230106	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:113230106G>T	ENST00000393020.1	+	17	1873	c.1468G>T	c.(1468-1470)Gac>Tac	p.D490Y	TTC12_ENST00000529221.1_Missense_Mutation_p.D490Y|TTC12_ENST00000483239.2_Missense_Mutation_p.D496Y|TTC12_ENST00000478125.1_3'UTR|TTC12_ENST00000314756.3_Missense_Mutation_p.D490Y			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	490							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GGAGGATGTGGACCTGTTCAG	0.478000													54	136					5.12816e-46	9.68975e-46	0.870114	1	0
CARD14	79092	broad.mit.edu	37	17	78163550	78163550	+	Splice_Site	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:78163550A>T	ENST00000573882.1	+	8	1379		c.e8-1		CARD14_ENST00000570421.1_Splice_Site|CARD14_ENST00000344227.2_Splice_Site|CARD14_ENST00000392434.2_Splice_Site|CARD14_ENST00000573754.1_Splice_Site			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14						activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCTCTGCCCCAGGCGGAGAAG	0.677000													3	24					0	0	0.150653	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19715876	19715876	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:19715876C>T	ENST00000284885.3	-	12	1408	c.1375G>A	c.(1375-1377)Gga>Aga	p.G459R		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	459	MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CAATTGTCTCCATAATTTCCT	0.294000													11	46					0	0	0.361761	0	0
KRTAP3-2	83897	broad.mit.edu	37	17	39155996	39155996	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:39155996G>T	ENST00000391587.1	-	1	142	c.110C>A	c.(109-111)cCa>cAa	p.P37Q		NM_031959.2	NP_114165.1	Q9BYR7	KRA32_HUMAN	keratin associated protein 3-2	37	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			endometrium(1)|large_intestine(1)|lung(1)	3		Breast(137;0.00043)				AACTGTGTGTGGGCAGGTGCT	0.627000													15	167					3.41278e-10	4.72267e-10	0.520397	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128862050	128862050	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:128862050A>T	ENST00000274487.4	+	4	1114	c.969A>T	c.(967-969)caA>caT	p.Q323H	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	323					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AATTACCTCAAGAATACAACA	0.383000													19	49					0	0	0.592651	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333386	28333386	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:28333386A>C	ENST00000377255.3	+	7	1238	c.941A>C	c.(940-942)cAc>cCc	p.H314P	ZKSCAN3_ENST00000341464.5_Missense_Mutation_p.H166P|ZKSCAN3_ENST00000252211.2_Missense_Mutation_p.H314P	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	314					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						GGGAGGCGGCACATCTGCCAT	0.493000													15	43					0	0	0.500413	0	0
OR10C1	442194	broad.mit.edu	37	6	29408673	29408673	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:29408673C>A	ENST00000444197.2	+	1	1591	c.881C>A	c.(880-882)aCa>aAa	p.T294K	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTGCGGAACACAGAGGTCAAA	0.542000													27	115					6.05902e-23	1.07198e-22	0.788014	1	0
IPO9	55705	broad.mit.edu	37	1	201844005	201844005	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:201844005A>T	ENST00000361565.4	+	22	2948	c.2879A>T	c.(2878-2880)gAg>gTg	p.E960V		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	960				E -> G (in Ref. 4; BAC11173).	protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						gaagaggaggaggaggaggaT	0.443000													37	57					0	0	0.796494	0	0
SMARCA1	6594	broad.mit.edu	37	X	128599910	128599910	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:128599910G>T	ENST00000371122.4	-	22	2857	c.2728C>A	c.(2728-2730)Cag>Aag	p.Q910K	SMARCA1_ENST00000371121.3_Missense_Mutation_p.Q898K|SMARCA1_ENST00000371123.1_Missense_Mutation_p.Q898K	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	910					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						TCAATGTCCTGTAATTCATTG	0.343000													23	55					2.70639e-06	3.24087e-06	0.624587	1	0
MAB21L1	4081	broad.mit.edu	37	13	36049916	36049916	+	Silent	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:36049916G>T	ENST00000379919.4	-	1	916	c.360C>A	c.(358-360)tcC>tcA	p.S120S	NBEA_ENST00000540320.1_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000310336.4_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	120					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		AGAGGTAGCCGGAGGCGGTAA	0.597000													14	35					6.31663e-08	8.18095e-08	0.479597	1	0
RIMS1	22999	broad.mit.edu	37	6	73108696	73108696	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:73108696G>A	ENST00000264839.7	+	29	4307	c.4307G>A	c.(4306-4308)tGt>tAt	p.C1436Y	RIMS1_ENST00000520567.1_Missense_Mutation_p.C1237Y|RIMS1_ENST00000517827.1_Missense_Mutation_p.C721Y|RIMS1_ENST00000518273.1_Missense_Mutation_p.C1266Y|RIMS1_ENST00000517960.1_Missense_Mutation_p.C1370Y|RIMS1_ENST00000425662.2_Missense_Mutation_p.C655Y|RIMS1_ENST00000414192.2_Missense_Mutation_p.C114Y|RIMS1_ENST00000491071.2_Missense_Mutation_p.C1376Y|RIMS1_ENST00000431478.2_3'UTR|RIMS1_ENST00000522291.1_Missense_Mutation_p.C1186Y|RIMS1_ENST00000538414.1_Missense_Mutation_p.C393Y|RIMS1_ENST00000401910.3_Missense_Mutation_p.C907Y|RIMS1_ENST00000348717.5_Missense_Mutation_p.C1370Y|RIMS1_ENST00000521978.1_Missense_Mutation_p.C1587Y|RIMS1_ENST00000523963.1_Missense_Mutation_p.C712Y			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1587					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AATGGGGCCTGTATAGCCAAG	0.328000													3	15					0	0	0.115264	0	0
ING1	3621	broad.mit.edu	37	13	111371692	111371692	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:111371692G>A	ENST00000375774.3	+	2	1144	c.682G>A	c.(682-684)Ggc>Agc	p.G228S	ING1_ENST00000333219.7_Missense_Mutation_p.G85S|ING1_ENST00000338450.7_Missense_Mutation_p.G41S|ING1_ENST00000375775.3_Missense_Mutation_p.G16S|ING1_ENST00000464141.1_3'UTR	NM_005537.4	NP_005528.3	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1	228					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			endometrium(4)|large_intestine(6)|lung(1)|ovary(1)	12	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			CCAGGAGCTGGGCGACGAGAA	0.657000													6	69					0	0	0.278610	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962409	73962409	+	Missense_Mutation	SNP	G	G	T	rs138583612	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:73962409G>T	ENST00000373468.1	-	3	2634	c.1983C>A	c.(1981-1983)caC>caA	p.H661Q	KIAA2022_ENST00000055682.5_Missense_Mutation_p.H661Q			Q5QGS0	K2022_HUMAN	KIAA2022	661					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GATTACTAGCGTGCCTCTGAT	0.398000													4	18					0.00909568	0.00946462	0.150653	1	0
IRS1	3667	broad.mit.edu	37	2	227660323	227660323	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:227660323C>A	ENST00000305123.4	-	1	4152	c.3132G>T	c.(3130-3132)ccG>ccT	p.P1044P		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	1044					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GAGGCCCAGTCGGGGAAGCAG	0.662000													8	17					0.000157383	0.000176428	0.278610	1	0
ARSH	347527	broad.mit.edu	37	X	2936658	2936658	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:2936658G>C	ENST00000381130.2	+	5	848	c.848G>C	c.(847-849)cGc>cCc	p.R283P		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	283						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTTGTTGGGCGCAGTAAATAT	0.413000													19	54					0	0	0.693898	0	0
TRPS1	7227	broad.mit.edu	37	8	116617184	116617184	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:116617184C>G	ENST00000395715.3	-	4	1589	c.1012G>C	c.(1012-1014)Gat>Cat	p.D338H	TRPS1_ENST00000520276.1_Missense_Mutation_p.D329H|TRPS1_ENST00000220888.5_Missense_Mutation_p.D325H|TRPS1_ENST00000519076.1_Missense_Mutation_p.D279H|TRPS1_ENST00000519674.1_Missense_Mutation_p.D325H	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	325					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCTTGGCAATCTGGTGTTTTC	0.418000									Langer-Giedion syndrome				23	58					0	0	0.717897	0	0
IPO9	55705	broad.mit.edu	37	1	201844004	201844004	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:201844004G>C	ENST00000361565.4	+	22	2947	c.2878G>C	c.(2878-2880)Gag>Cag	p.E960Q		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	960				E -> G (in Ref. 4; BAC11173).	protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						ggaagaggaggaggaggagga	0.448000													35	57					0	0	0.779181	0	0
ADC	113451	broad.mit.edu	37	1	33560255	33560255	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:33560255G>A	ENST00000294517.6	+	8	1281	c.694G>A	c.(694-696)Gtt>Att	p.V232I	ADC_ENST00000373443.3_Missense_Mutation_p.V232I|ADC_ENST00000358680.3_Intron|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373440.1_Intron|ADC_ENST00000373441.1_Missense_Mutation_p.V232I|ADC_ENST00000398167.1_Missense_Mutation_p.V232I	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	232					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CAAGATGCACGTTCTGGACCT	0.587000											OREG0013339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	72					0	0	0.624587	0	0
F8	2157	broad.mit.edu	37	X	154091475	154091475	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:154091475C>A	ENST00000360256.4	-	23	6657	c.6457G>T	c.(6457-6459)Ggg>Tgg	p.G2153W	F8_ENST00000330287.6_Missense_Mutation_p.G18W	NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2153	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGTTTTATCCCAGATGAATCC	0.378000													33	94					7.63091e-17	1.2384e-16	0.834066	1	0
DRP2	1821	broad.mit.edu	37	X	100509550	100509550	+	Splice_Site	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:100509550C>A	ENST00000395209.3	+	18	2641	c.2114_splice	c.e18+1	p.T705_splice	DRP2_ENST00000538510.1_Splice_Site_p.T705_splice|DRP2_ENST00000402866.1_Splice_Site_p.T705_splice|DRP2_ENST00000541709.1_Splice_Site_p.T627_splice	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	705					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TACAGTGAGACGTGAGTACTG	0.542000													16	67					3.73194e-20	6.33385e-20	0.592651	1	0
OTOGL	283310	broad.mit.edu	37	12	80665514	80665514	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:80665514A>G	ENST00000458043.2	+	23	2584	c.2578A>G	c.(2578-2580)Aca>Gca	p.T860A	OTOGL_ENST00000547103.1_Missense_Mutation_p.T860A	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTGTGAGACTACATGTGCAAA	0.468000													7	86					0	0	0.361761	0	0
ANKRD17	26057	broad.mit.edu	37	4	73944596	73944596	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:73944596G>T	ENST00000358602.4	-	31	7287	c.7171C>A	c.(7171-7173)Cag>Aag	p.Q2391K	ANKRD17_ENST00000509867.2_Missense_Mutation_p.Q2278K|ANKRD17_ENST00000330838.6_Missense_Mutation_p.Q2140K	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2391					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GATACTGACTGTGCAGAAGAA	0.403000													9	40					0.000673444	0.000740012	0.361761	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685398	125685398	+	Silent	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:125685398T>A	ENST00000371126.1	-	1	1436	c.1194A>T	c.(1192-1194)gcA>gcT	p.A398A		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	398										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						GCTTCCTCCTTGCAGGTCCCG	0.577000													19	79					0	0	0.557998	0	0
KCNE4	23704	broad.mit.edu	37	2	223917596	223917596	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:223917596C>A	ENST00000281830.3	+	2	532	c.201C>A	c.(199-201)gcC>gcA	p.A67A	KCNE4_ENST00000488477.2_Intron|KCNE4_ENST00000604125.1_Silent_p.A16A			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	16						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCACCGCCGCCTCCAGCAGCC	0.612000													11	46					4.36969e-10	5.99709e-10	0.435327	1	0
ACSL3	2181	broad.mit.edu	37	2	223795453	223795453	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:223795453A>C	ENST00000357430.3	+	14	2186	c.1655A>C	c.(1654-1656)gAa>gCa	p.E552A	ACSL3_ENST00000392066.3_Missense_Mutation_p.E552A	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	552					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	GATTTCTTTGAAGATGAAAAT	0.393000			T	ETV1	prostate								25	48					0	0	0.779181	0	0
COL27A1	85301	broad.mit.edu	37	9	116930612	116930612	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:116930612C>T	ENST00000356083.3	+	3	1168	c.777C>T	c.(775-777)acC>acT	p.T259T		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	259					cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GACCTTTTACCTTCCAGTCCG	0.607000													19	58					0	0	0.624587	0	0
GDA	9615	broad.mit.edu	37	9	74842864	74842864	+	Silent	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr9:74842864G>C	ENST00000358399.3	+	9	921	c.828G>C	c.(826-828)gtG>gtC	p.V276V	GDA_ENST00000545168.1_Silent_p.V202V|GDA_ENST00000376986.1_Silent_p.V198V|GDA_ENST00000238018.4_Silent_p.V276V|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000376989.3_Silent_p.V215V	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	276					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		TCCAGACAGTGATGGCACACG	0.468000													11	35					0	0	0.457914	0	0
RP1L1	94137	broad.mit.edu	37	8	10468137	10468137	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:10468137C>T	ENST00000382483.3	-	4	3694	c.3471G>A	c.(3469-3471)ctG>ctA	p.L1157L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1157					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		ATCCTGGCCACAGGTCCTTCG	0.587000													16	30					0	0	0.575678	0	0
ZFHX3	463	broad.mit.edu	37	16	72830330	72830330	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:72830330G>T	ENST00000268489.5	-	9	6923	c.6251C>A	c.(6250-6252)cCg>cAg	p.P2084Q	ZFHX3_ENST00000397992.5_Missense_Mutation_p.P1170Q	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2084					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTGGGTGAGCGGCACTGATGG	0.667000													11	115					0.00136819	0.00147668	0.411799	1	0
C21orf33	8209	broad.mit.edu	37	21	45563124	45563124	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr21:45563124C>T	ENST00000291577.6	+	6	652	c.559C>T	c.(559-561)Ctc>Ttc	p.L187F	C21orf33_ENST00000348499.5_Missense_Mutation_p.L156F	NM_004649.6	NP_004640.3	P30042	ES1_HUMAN	chromosome 21 open reading frame 33	187						mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		GGCCAAGGTGCTCAGAGGCGT	0.612000													7	43					0	0	0.278610	0	0
TTN	7273	broad.mit.edu	37	2	179622517	179622517	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:179622517T>C	ENST00000589042.1	-	45	10654	c.10430A>G	c.(10429-10431)cAc>cGc	p.H3477R	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.H3431R|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000360870.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3164							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCCCGTTGTGCACCCTGAG	0.473000													18	135					0	0	0.654019	0	0
SIX2	10736	broad.mit.edu	37	2	45233317	45233317	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:45233317C>A	ENST00000303077.6	-	2	1187	c.868G>T	c.(868-870)Ggc>Tgc	p.G290C		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	290						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTCTAGGAGCCCAGGTCCACG	0.647000													41	71					7.77372e-23	1.37171e-22	0.870114	1	0
PC	5091	broad.mit.edu	37	11	66620111	66620111	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:66620111T>C	ENST00000393960.1	-	15	1905	c.1624A>G	c.(1624-1626)Aga>Gga	p.R542G	PC_ENST00000393958.2_Missense_Mutation_p.R542G|PC_ENST00000393955.2_Missense_Mutation_p.R542G	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	542					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGGATGTCTCTGAAACCAGCC	0.637000													18	49					0	0	0.608945	0	0
FOXN2	3344	broad.mit.edu	37	2	48573477	48573477	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:48573477C>G	ENST00000340553.3	+	3	385	c.124C>G	c.(124-126)Ccg>Gcg	p.P42A		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	42					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TGCTGCCAGGCCGAAGGCCAC	0.468000													28	85					0	0	0.760397	0	0
FAT2	2196	broad.mit.edu	37	5	150947771	150947771	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:150947771G>T	ENST00000261800.5	-	1	734	c.722C>A	c.(721-723)gCa>gAa	p.A241E		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	241	Cadherin 2.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCACAAGTGCAGCCAGGCT	0.572000													13	25					5.50884e-06	6.50335e-06	0.411799	1	0
CLCA1	1179	broad.mit.edu	37	1	86934668	86934668	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:86934668A>T	ENST00000234701.3	+	2	365	c.14A>T	c.(13-15)aAg>aTg	p.K5M	CLCA1_ENST00000394711.1_Missense_Mutation_p.K5M			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	5					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GGGCCATTTAAGAGTTCTGTG	0.408000													18	112					0	0	0.654019	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904292	144904292	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:144904292C>G	ENST00000370490.1	+	1	4604	c.349C>G	c.(349-351)Ctc>Gtc	p.L117V	SLITRK2_ENST00000447897.2_Missense_Mutation_p.L117V|SLITRK2_ENST00000413937.2_Missense_Mutation_p.L117V|SLITRK2_ENST00000434188.2_Missense_Mutation_p.L117V|SLITRK2_ENST00000428560.2_Missense_Mutation_p.L117V			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	117						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					AAGACTGCATCTCAACAACAA	0.502000													8	63					0	0	0.361761	0	0
PLXNB3	5365	broad.mit.edu	37	X	153036515	153036515	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153036515C>T	ENST00000538543.1	+	7	740	c.641C>T	c.(640-642)tCa>tTa	p.S214L	PLXNB3_ENST00000361971.5_Silent_p.L744L|PLXNB3_ENST00000538282.1_Silent_p.L354L|PLXNB3_ENST00000538776.1_Silent_p.L397L|PLXNB3_ENST00000538966.1_Silent_p.L767L			Q9ULL4	PLXB3_HUMAN	plexin B3	0	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					ATTCAGGCCTCATCCACTGCC	0.647000													41	128					0	0	0.870114	0	0
CCDC19	25790	broad.mit.edu	37	1	159858145	159858145	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:159858145G>A	ENST00000426543.2	-	4	614	c.159C>T	c.(157-159)acC>acT	p.T53T	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Silent_p.T138T			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	138						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TAACTACCATGGTGGCTTCCT	0.527000													7	46					0	0	0.307466	0	0
AEBP1	165	broad.mit.edu	37	7	44152310	44152310	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:44152310G>A	ENST00000223357.3	+	18	2676	c.2371G>A	c.(2371-2373)Gca>Aca	p.A791T	AEBP1_ENST00000450684.2_Missense_Mutation_p.A366T	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	791	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						AGCCATGGCAGCAGCCCGGGG	0.662000													3	28					0	0	0.150653	0	0
IQSEC2	23096	broad.mit.edu	37	X	53265579	53265579	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:53265579C>A	ENST00000396435.3	-	13	3576	c.3376G>T	c.(3376-3378)Gag>Tag	p.E1126*	IQSEC2_ENST00000375368.5_Nonsense_Mutation_p.E1116*|IQSEC2_ENST00000375365.2_Nonsense_Mutation_p.E921*	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	1116					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						TAAGTGTCCTCCAGGCTACTG	0.632000													10	25					9.31168e-06	1.09154e-05	0.435327	1	0
ITIH6	347365	broad.mit.edu	37	X	54776401	54776401	+	Missense_Mutation	SNP	G	G	T	rs144428047	byFrequency	TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:54776401G>T	ENST00000218436.6	-	13	3898	c.3869C>A	c.(3868-3870)gCt>gAt	p.A1290D		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1290					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CCAGCAGGAAGCCCAGCGGGG	0.587000													12	40					3.27435e-08	4.2573e-08	0.457914	1	0
ANXA5	308	broad.mit.edu	37	4	122605858	122605858	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:122605858C>A	ENST00000296511.5	-	4	448	c.163G>T	c.(163-165)Gca>Tca	p.A55S	ANXA5_ENST00000509016.1_5'UTR|ANXA5_ENST00000501272.2_Intron|ANXA5_ENST00000515017.1_Intron	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	55					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						TTAAAAGCTGCAGAGATTTCC	0.433000													35	104					8.16277e-20	1.37837e-19	0.827153	1	0
PCDH10	57575	broad.mit.edu	37	4	134072784	134072784	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:134072784C>A	ENST00000264360.4	+	1	2315	c.1489C>A	c.(1489-1491)Cag>Aag	p.Q497K		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	497	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CGCCAACGCCCAGCTTGCCTA	0.592000													6	41					0.00198382	0.0021342	0.248553	1	0
HYDIN	54768	broad.mit.edu	37	16	70908744	70908744	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:70908744C>G	ENST00000393567.2	-	63	10786	c.10636G>C	c.(10636-10638)Gag>Cag	p.E3546Q		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3546										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTATTTTCCTCTGTGATGTAG	0.517000													10	11					0	0	0.457914	0	0
TTN	7273	broad.mit.edu	37	2	179598397	179598397	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:179598397C>A	ENST00000589042.1	-	53	15943	c.15719G>T	c.(15718-15720)tGc>tTc	p.C5240F	TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.C3996F|TTN_ENST00000591111.1_Missense_Mutation_p.C4923F|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4923	Ig-like 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGCCAGGCACGTGTATTT	0.373000													31	60					1.36239e-07	1.73419e-07	0.779181	1	0
FAM131B	9715	broad.mit.edu	37	7	143053998	143053998	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:143053998G>A	ENST00000409408.1	-	6	2352	c.644C>T	c.(643-645)cCg>cTg	p.P215L	FAM131B_ENST00000443739.2_Missense_Mutation_p.P243L|FAM131B_ENST00000409346.1_Missense_Mutation_p.P215L|FAM131B_ENST00000409222.3_Missense_Mutation_p.P215L|FAM131B_ENST00000409578.1_Missense_Mutation_p.P231L			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	215										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					TCCTGTGGCCGGAGAGGCAAT	0.557000													6	62					0	0	0.248553	0	0
PCDH8	5100	broad.mit.edu	37	13	53422312	53422312	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:53422312T>A	ENST00000377942.3	-	1	463	c.260A>T	c.(259-261)gAc>gTc	p.D87V	PCDH8_ENST00000338862.4_Missense_Mutation_p.D87V	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	87	Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGGCCGGCGTCCCCGACGGT	0.647000													6	47					0	0	0.217242	0	0
HOXB13	10481	broad.mit.edu	37	17	46804240	46804240	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:46804240G>C	ENST00000290295.7	-	2	1351	c.767C>G	c.(766-768)tCg>tGg	p.S256W		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	256					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						CTGGCGCTCCGAGAGGCTGGT	0.562000													23	165					0	0	0.706142	0	0
AHNAK	79026	broad.mit.edu	37	11	62297165	62297165	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:62297165T>G	ENST00000378024.4	-	5	4998	c.4724A>C	c.(4723-4725)cAg>cCg	p.Q1575P	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1575					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTGTGCGTCTGTATATTCAT	0.433000													34	70					0	0	0.819951	0	0
FGD1	2245	broad.mit.edu	37	X	54521721	54521721	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:54521721C>A	ENST00000375135.3	-	1	878	c.145G>T	c.(145-147)Ggt>Tgt	p.G49C		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	49	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AGAGCCGAACCTGAGCCCCTG	0.736000													7	3					0.0381472	0.0392657	0.278610	1	0
OR8B4	283162	broad.mit.edu	37	11	124294404	124294404	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:124294404A>C	ENST00000356130.3	-	1	385	c.364T>G	c.(364-366)Tat>Gat	p.Y122D		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		ATGGCCACATAGCGATCATAG	0.463000													29	91					0	0	0.804634	0	0
DOCK2	1794	broad.mit.edu	37	5	169141438	169141438	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:169141438G>T	ENST00000256935.8	+	19	1998	c.1918G>T	c.(1918-1920)Gtg>Ttg	p.V640L	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.V132L	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	640	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTGAAGATTGTGGATGGAGA	0.448000													11	64					3.27435e-08	4.2573e-08	0.457914	1	0
PTPRS	5802	broad.mit.edu	37	19	5219424	5219424	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:5219424G>T	ENST00000372412.4	-	23	4056	c.3823C>A	c.(3823-3825)Cag>Aag	p.Q1275K	PTPRS_ENST00000357368.4_Missense_Mutation_p.Q1274K|PTPRS_ENST00000588012.1_Missense_Mutation_p.Q1252K|PTPRS_ENST00000353284.2_Missense_Mutation_p.Q843K|PTPRS_ENST00000348075.2_Missense_Mutation_p.Q1252K|PTPRS_ENST00000587303.1_Missense_Mutation_p.Q1274K|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000262963.6_Missense_Mutation_p.Q1270K|PTPRS_ENST00000592099.1_Missense_Mutation_p.Q843K			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1274					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		ACGATGGGCTGGGGGTCCGGG	0.582000													26	73					1.45844e-13	2.18601e-13	0.769981	1	0
MRE11A	4361	broad.mit.edu	37	11	94212910	94212910	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:94212910T>G	ENST00000323929.3	-	5	554	c.332A>C	c.(331-333)tAt>tCt	p.Y111S	MRE11A_ENST00000540013.1_Missense_Mutation_p.Y111S|MRE11A_ENST00000393241.4_Missense_Mutation_p.Y111S|MRE11A_ENST00000407439.3_Missense_Mutation_p.Y114S|MRE11A_ENST00000323977.3_Missense_Mutation_p.Y111S	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	111					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GCCATCTTGATAGTTCACCCA	0.348000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				19	47					0	0	0.608945	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131462	107131462	+	RNA	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:107131462C>A	ENST00000390632.2	-	0	98																											AAGGAAAACCCAGCTCAGCCC	0.488000													37	124					3.10996e-30	5.66761e-30	0.870114	1	0
ACSM2B	348158	broad.mit.edu	37	16	20563602	20563602	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:20563602G>T	ENST00000329697.6	-	6	926	c.758C>A	c.(757-759)gCc>gAc	p.A253D	ACSM2B_ENST00000565232.1_Missense_Mutation_p.A253D|ACSM2B_ENST00000567001.1_Missense_Mutation_p.A253D|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565322.1_Missense_Mutation_p.A174D	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	253					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TATATCAGAGGCTTGCAGGCC	0.453000													33	97					2.56175e-15	4.03944e-15	0.870114	1	0
HNRNPCL1	343069	broad.mit.edu	37	1	12908139	12908139	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:12908139C>A	ENST00000317869.6	-	2	229	c.4G>T	c.(4-6)Gcc>Tcc	p.A2S		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ACGTTGCTGGCCATTGTGTTG	0.483000													9	152					0.00829132	0.00870915	0.361761	1	0
MDGA2	161357	broad.mit.edu	37	14	47389255	47389255	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:47389255G>A	ENST00000426342.1	-	10	2050	c.1304C>T	c.(1303-1305)gCa>gTa	p.A435V	MDGA2_ENST00000399232.2_Missense_Mutation_p.A733V|MDGA2_ENST00000439988.2_Missense_Mutation_p.A664V|MDGA2_ENST00000357362.3_Missense_Mutation_p.A435V	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	664	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CCGATCCACTGCATCAGGATT	0.428000													15	57					0	0	0.539581	0	0
TEPP	374739	broad.mit.edu	37	16	58018631	58018631	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:58018631C>A	ENST00000290871.5	+	4	579	c.542C>A	c.(541-543)cCc>cAc	p.P181H	TEPP_ENST00000569996.1_3'UTR|TEPP_ENST00000441824.2_Missense_Mutation_p.P181H	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	181						extracellular region				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						GTGGACTGGCCCTGCTTCACG	0.652000													3	13					0.00909568	0.00946462	0.150653	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133004	91133004	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:91133004G>T	ENST00000373094.1	+	2	2610	c.1765G>T	c.(1765-1767)Gta>Tta	p.V589L	PCDH11X_ENST00000361655.2_Missense_Mutation_p.V589L|PCDH11X_ENST00000373088.1_Missense_Mutation_p.V589L|PCDH11X_ENST00000298274.8_Missense_Mutation_p.V589L|PCDH11X_ENST00000395337.2_Missense_Mutation_p.V589L|PCDH11X_ENST00000504220.1_Missense_Mutation_p.V589L|PCDH11X_ENST00000373097.1_Missense_Mutation_p.V589L|PCDH11X_ENST00000361724.1_Missense_Mutation_p.V589L|PCDH11X_ENST00000406881.1_Missense_Mutation_p.V589L	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	589	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GCATGGTACAGTAGGACTAAT	0.383000													34	86					5.78141e-17	9.40537e-17	0.864702	1	0
SEC23A	10484	broad.mit.edu	37	14	39531014	39531014	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:39531014T>C	ENST00000537403.1	-	9	2056	c.854A>G	c.(853-855)cAt>cGt	p.H285R	SEC23A_ENST00000545328.2_Missense_Mutation_p.H458R|SEC23A_ENST00000307712.6_Missense_Mutation_p.H487R|SEC23A_ENST00000536508.1_Missense_Mutation_p.H361R			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	487					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		CCCACTTGAATGCTGATACTG	0.403000													40	147					0	0	0.870114	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621063	99621063	+	Translation_Start_Site	SNP	T	T	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:99621063T>G	ENST00000324306.6	+	0	168				ZKSCAN1_ENST00000535170.1_Intron|ZKSCAN1_ENST00000426572.1_De_novo_Start_OutOfFrame	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1						viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AAACACATCATAAAACCTCCC	0.428000													16	29					0	0	0.520397	0	0
LARP7	51574	broad.mit.edu	37	4	113567579	113567579	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr4:113567579G>T	ENST00000509061.1	+	5	599	c.296G>T	c.(295-297)aGa>aTa	p.R99I	LARP7_ENST00000344442.5_Missense_Mutation_p.R92I|LARP7_ENST00000324052.6_Missense_Mutation_p.R92I	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	92	HTH La-type RNA-binding.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TTAATTGCCAGAGCATTGAGA	0.259000													17	49					9.95505e-16	1.59233e-15	0.624587	1	0
FLT4	2324	broad.mit.edu	37	5	180048108	180048108	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:180048108G>T	ENST00000261937.6	-	14	2243	c.2165C>A	c.(2164-2166)tCt>tAt	p.S722Y	FLT4_ENST00000502649.1_Missense_Mutation_p.S722Y|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.S722Y	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	722	Ig-like C2-type 7.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTCCCTACCAGACTTTTCCTC	0.672000													6	35					0.0215528	0.0222534	0.217242	1	0
FUT6	2528	broad.mit.edu	37	19	5832237	5832237	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:5832237G>C	ENST00000318336.4	-	3	1536	c.342C>G	c.(340-342)taC>taG	p.Y114*	FUT6_ENST00000524754.1_Nonsense_Mutation_p.Y114*|FUT6_ENST00000286955.5_Nonsense_Mutation_p.Y114*|FUT6_ENST00000592563.1_Nonsense_Mutation_p.Y114*|FUT6_ENST00000527106.1_Nonsense_Mutation_p.Y114*	NM_000150.2	NP_000141.1	P51993	FUT6_HUMAN	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	114					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)	6						CACTGGGGTTGTACATGACCT	0.632000													27	96					0	0	0.769981	0	0
FAM47C	442444	broad.mit.edu	37	X	37027473	37027473	+	Silent	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:37027473C>A	ENST00000358047.3	+	1	1042	c.990C>A	c.(988-990)ctC>ctA	p.L330L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	330										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGTCCCATCTCCACCCAGAGC	0.607000													37	98					1.47197e-15	2.33763e-15	0.834066	1	0
COL14A1	7373	broad.mit.edu	37	8	121180457	121180457	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:121180457G>T	ENST00000297848.3	+	5	677	c.407G>T	c.(406-408)gGa>gTa	p.G136V	COL14A1_ENST00000309791.4_Missense_Mutation_p.G136V|COL14A1_ENST00000537875.1_Missense_Mutation_p.G136V|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.G136V	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	136					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GTGGACAGAGGAAATGGGAGT	0.373000													10	83					2.80697e-09	3.76711e-09	0.387290	1	0
FAM49A	81553	broad.mit.edu	37	2	16742505	16742505	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:16742505C>A	ENST00000381323.3	-	8	774	c.554G>T	c.(553-555)cGa>cTa	p.R185L	FAM49A_ENST00000355549.2_Missense_Mutation_p.R185L|FAM49A_ENST00000406434.1_Missense_Mutation_p.R185L	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	185						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GAGGGACATTCGATTGGCCAT	0.403000													13	82					1.5842e-08	2.08826e-08	0.435327	1	0
RHD	6007	broad.mit.edu	37	1	25611103	25611103	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:25611103G>C	ENST00000328664.4	+	2	343	c.188G>C	c.(187-189)gGc>gCc	p.G63A	RHD_ENST00000568195.1_Missense_Mutation_p.G63A|RHD_ENST00000357542.4_Missense_Mutation_p.G63A|RHD_ENST00000423810.2_Missense_Mutation_p.G63A|RHD_ENST00000454452.2_Missense_Mutation_p.G63A|RHD_ENST00000342055.5_Missense_Mutation_p.G63A|RHD_ENST00000417538.2_Missense_Mutation_p.G63A|RHD_ENST00000423253.1_3'UTR	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	63						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ATTGGCTTGGGCTTCCTCACC	0.597000													6	42					0	0	0.248553	0	0
LPA	4018	broad.mit.edu	37	6	160962169	160962169	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr6:160962169C>T	ENST00000447678.1	-	36	5684	c.5564G>A	c.(5563-5565)tGg>tAg	p.W1855*	LPA_ENST00000316300.5_Nonsense_Mutation_p.W1855*|LPA_ENST00000484276.1_5'UTR	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4363	Kringle 17.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGTCAGCACCCACTCTGGGGA	0.448000													11	34					0	0	0.500413	0	0
MUC17	140453	broad.mit.edu	37	7	100685424	100685424	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:100685424C>T	ENST00000306151.4	+	3	10791	c.10727C>T	c.(10726-10728)tCt>tTt	p.S3576F		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3576	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGGAAGCTCTTCATTAACA	0.473000													24	178					0	0	0.693898	0	0
NALCN	259232	broad.mit.edu	37	13	101714412	101714412	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:101714412C>A	ENST00000251127.6	-	41	4744	c.4663G>T	c.(4663-4665)Gcg>Tcg	p.A1555S		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1555						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGCTCCCTCGCCAGGAGTTCC	0.572000													9	64					1.58986e-06	1.94934e-06	0.361761	1	0
MAOA	4128	broad.mit.edu	37	X	43599971	43599971	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:43599971C>A	ENST00000338702.3	+	11	1273	c.1150C>A	c.(1150-1152)Caa>Aaa	p.Q384K	MAOA_ENST00000542639.1_Missense_Mutation_p.Q251K	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	384					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	GCTGGGATCCCAAGAAGCTTT	0.363000													7	10					6.40141e-05	7.34895e-05	0.387290	1	0
PLXNA3	55558	broad.mit.edu	37	X	153695405	153695405	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:153695405G>T	ENST00000369682.3	+	18	3288	c.3113G>T	c.(3112-3114)aGc>aTc	p.S1038I		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1038	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTAGTGGAAGCACTGCCATC	0.657000													52	108					2.3441e-25	4.18052e-25	0.870114	1	0
KDELC1	79070	broad.mit.edu	37	13	103443272	103443272	+	Silent	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:103443272A>G	ENST00000376004.4	-	6	1398	c.1062T>C	c.(1060-1062)atT>atC	p.I354I	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	354						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CAAAAAATGAAATATGTTTCA	0.338000													7	33					0	0	0.248553	0	0
EPSTI1	94240	broad.mit.edu	37	13	43469228	43469228	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr13:43469228G>T	ENST00000313640.7	-	11	929	c.865C>A	c.(865-867)Ctg>Atg	p.L289M	EPSTI1_ENST00000313624.7_Missense_Mutation_p.L278M|EPSTI1_ENST00000398762.3_Missense_Mutation_p.L289M	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	289										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		AGTCGGTCCAGAAAAGCATTA	0.418000													6	17					0.000157383	0.000176428	0.278610	1	0
RFX1	5989	broad.mit.edu	37	19	14077486	14077486	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:14077486C>T	ENST00000254325.4	-	13	2044	c.1810G>A	c.(1810-1812)Gac>Aac	p.D604N		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	604					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GCTTTGATGTCCCCGGGCCCG	0.682000													13	70					0	0	0.520397	0	0
NMUR1	10316	broad.mit.edu	37	2	232389994	232389994	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:232389994C>T	ENST00000305141.4	-	3	1174	c.1041G>A	c.(1039-1041)ctG>ctA	p.L347L		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	347					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCGCCGAGCCCAGGTAGAAGA	0.647000													26	56					0	0	0.788014	0	0
COL14A1	7373	broad.mit.edu	37	8	121222024	121222024	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:121222024C>A	ENST00000297848.3	+	12	1621	c.1351C>A	c.(1351-1353)Ctg>Atg	p.L451M	COL14A1_ENST00000309791.4_Missense_Mutation_p.L451M|COL14A1_ENST00000537875.1_Missense_Mutation_p.L451M|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.L356M	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	451	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGACCTTCTACTGTACGACGT	0.443000													48	89					1.07796e-43	2.03106e-43	0.870114	1	0
DDX53	168400	broad.mit.edu	37	X	23019473	23019473	+	Silent	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:23019473G>A	ENST00000327968.5	+	1	1387	c.1299G>A	c.(1297-1299)ctG>ctA	p.L433L	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	433						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						TTGGTAATCTGAATCTAGTGG	0.378000													47	86					0	0	0.870114	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435837	5435837	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:5435837C>T	ENST00000380419.3	-	4	1021	c.984G>A	c.(982-984)ggG>ggA	p.G328G	TUBAL3_ENST00000479328.1_Silent_p.G288G	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	328					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						GGACCACATCCCCTCTATAGA	0.532000													11	54					0	0	0.435327	0	0
C2CD3	26005	broad.mit.edu	37	11	73817481	73817481	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:73817481G>A	ENST00000334126.7	-	13	2246	c.2020C>T	c.(2020-2022)Ctt>Ttt	p.L674F	C2CD3_ENST00000313663.7_Missense_Mutation_p.L674F			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	674						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CTGAAAGAAAGCAGCTCTGAT	0.398000													14	83					0	0	0.520397	0	0
METTL22	79091	broad.mit.edu	37	16	8722955	8722955	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr16:8722955A>G	ENST00000381920.3	+	3	760	c.502A>G	c.(502-504)Atc>Gtc	p.I168V	METTL22_ENST00000561758.1_Missense_Mutation_p.I112V	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	168							methyltransferase activity			large_intestine(5)|lung(4)	9						CCCGCACGATATCATCAGAAT	0.542000													45	267					0	0	0.870114	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171777409	171777409	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr5:171777409G>A	ENST00000311601.5	-	10	1140	c.970C>T	c.(970-972)Cgg>Tgg	p.R324W	SH3PXD2B_ENST00000519643.1_Missense_Mutation_p.R324W	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	324					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTTCAAACCGCCCGTCCCTC	0.662000													9	59					0	0	0.411799	0	0
CTNNA2	1496	broad.mit.edu	37	2	80096941	80096941	+	Splice_Site	SNP	G	G	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:80096941G>A	ENST00000466387.1	+	9	1189		c.e9-1		CTNNA2_ENST00000541047.1_Splice_Site|CTNNA2_ENST00000496558.1_Splice_Site|CTNNA2_ENST00000540488.1_Splice_Site|CTNNA2_ENST00000361291.4_Splice_Site|CTNNA2_ENST00000402739.4_Splice_Site			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2						axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CACCACTGCAGGTGGAAGAGG	0.353000													6	69					0	0	0.278610	0	0
OR4X1	390113	broad.mit.edu	37	11	48285761	48285761	+	Missense_Mutation	SNP	G	G	T	rs143629082		TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:48285761G>T	ENST00000320048.1	+	1	349	c.349G>T	c.(349-351)Gcc>Tcc	p.A117S		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GATGGTGATGGCCTATGACCG	0.527000													29	63					3.76114e-14	5.71453e-14	0.796494	1	0
PRPF18	8559	broad.mit.edu	37	10	13647726	13647726	+	Silent	SNP	C	C	T			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:13647726C>T	ENST00000378572.3	+	4	505	c.345C>T	c.(343-345)ctC>ctT	p.L115L		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	115					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						TAGAGATCCTCACACCAGAAG	0.368000													19	101					0	0	0.639603	0	0
MACF1	23499	broad.mit.edu	37	1	39763377	39763377	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr1:39763377delC	ENST00000564288.1	+	21	3218	c.2441delC	c.(2440-2442)acfs	p.T814fs	MACF1_ENST00000567887.1_Frame_Shift_Del_p.T851fs|MACF1_ENST00000361689.2_Frame_Shift_Del_p.T819fs|MACF1_ENST00000545844.1_Frame_Shift_Del_p.T819fs|MACF1_ENST00000539005.1_Frame_Shift_Del_p.T819fs|MACF1_ENST00000372915.3_Frame_Shift_Del_p.T819fs|MACF1_ENST00000317713.7_Frame_Shift_Del_p.T819fs			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	819					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GACCACAACACCAGCTTATCC	0.463													14	86	---	---	---	---					
ST6GAL2	84620	broad.mit.edu	37	2	107423204	107423204	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:107423204delC	ENST00000409382.3	-	6	2130	c.1520delG	c.(1519-1521)gcfs	p.G507fs	ST6GAL2_ENST00000361686.4_Frame_Shift_Del_p.G507fs	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	507					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						AACCACCTTGCCCTTGCGATG	0.572													43	83	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179462483	179462484	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr2:179462483_179462484insC	ENST00000589042.1	-	294	57549_57550	c.57325_57326insG	c.(57325-57327)gatfs	p.D19109fs	TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Frame_Shift_Ins_p.D10236fs|TTN_ENST00000591111.1_Frame_Shift_Ins_p.D17468fs|TTN_ENST00000460472.2_Frame_Shift_Ins_p.D10044fs|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Frame_Shift_Ins_p.D16541fs|TTN_ENST00000359218.5_Frame_Shift_Ins_p.D10169fs|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17468	Fibronectin type-III 38.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCGGATCACCCCTCCAGCA	0.455													7	57	---	---	---	---					
SH3BP5	9467	broad.mit.edu	37	3	15373833	15373835	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:15373833_15373835delTCC	ENST00000383791.3	-	1	301_303	c.81_83delGGA	c.(79-84)gaa>ga	p.EE27del	SH3BP5_ENST00000408919.3_Intron|SH3BP5_ENST00000426925.1_Intron|SH3BP5_ENST00000253688.5_5'UTR|SH3BP5_ENST00000465894.2_Intron	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	27	Glu-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						catcccctcttcctcctcctcct	0.719													3	4	---	---	---	---					
RFT1	91869	broad.mit.edu	37	3	53157784	53157785	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:53157784_53157785insC	ENST00000296292.3	-	3	282_283	c.221_222insG	c.(220-222)gacfs	p.D74fs	RFT1_ENST00000394738.3_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	74					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		CTCGCTGGGTGCCCCCACTGAG	0.540													22	88	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr3:100148586_100148588delGAT	ENST00000383693.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)del	p.D10del	LNP1_ENST00000489752.1_In_Frame_Del_p.D10del	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													8	264	---	---	---	---					
SPAM1	6677	broad.mit.edu	37	7	123593877	123593877	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr7:123593877delG	ENST00000340011.5	+	3	610	c.253delG	c.(253-255)ggfs	p.G85fs	SPAM1_ENST00000460182.1_Frame_Shift_Del_p.G85fs|SPAM1_ENST00000402183.2_Frame_Shift_Del_p.G85fs|SPAM1_ENST00000439500.1_Frame_Shift_Del_p.G85fs|SPAM1_ENST00000223028.7_Frame_Shift_Del_p.G85fs	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	85					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AAACGCCACCGGGCAAGGTGT	0.433													10	62	---	---	---	---					
PPP2R2A	5520	broad.mit.edu	37	8	26218501	26218502	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:26218501_26218502insA	ENST00000380737.3	+	6	800_801	c.471_472insA	c.(469-474)ttggccfs	p.A158fs	PPP2R2A_ENST00000315985.7_Frame_Shift_Ins_p.A168fs	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TGCCAGTCTTTAGGCCTATGGA	0.337													8	78	---	---	---	---					
CNBD1	168975	broad.mit.edu	37	8	88298767	88298768	+	Splice_Site	INS	-	-	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr8:88298767_88298768insA	ENST00000518476.1	+	8	961_962	c.909_splice	c.e8-1	p.K304_splice		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	304										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TCTGTTTTAGGAAAAAATAAAA	0.277													2	4	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61824046	61824047	+	Splice_Site	INS	-	-	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr10:61824046_61824047insC	ENST00000280772.1	-	39	12511	c.12319_splice	c.e39-1	p.D4107_splice	ANK3_ENST00000355288.2_Splice_Site_p.D628_splice|ANK3_ENST00000373827.2_Splice_Site_p.D1488_splice|ANK3_ENST00000503366.1_Splice_Site_p.D1495_splice	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4107	Death.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCTTGCCAGTTCTGTAGAAAAG	0.302													8	83	---	---	---	---					
CCDC15	80071	broad.mit.edu	37	11	124861402	124861402	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr11:124861402delG	ENST00000529051.1	+	9	2213	c.1954delG	c.(1954-1956)ggfs	p.G652fs	CCDC15_ENST00000344762.5_Frame_Shift_Del_p.G652fs			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	652						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGATGAGAAAGGGAGAGAAGA	0.353													8	29	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46211516	46211517	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr12:46211516_46211517delTG	ENST00000334344.6	+	5	654_655	c.482_483delTG	c.(481-483)tfs	p.L161fs	ARID2_ENST00000422737.1_Frame_Shift_Del_p.L12fs	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	161					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.L161*(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TATAATAAATTGGTGCTTTCAC	0.351			"""N, S, F"""		hepatocellular carcinoma								34	58	---	---	---	---					
JPH4	84502	broad.mit.edu	37	14	24046649	24046649	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr14:24046649delC	ENST00000397118.3	-	3	916	c.14delG	c.(13-15)gcfs	p.G5fs	JPH4_ENST00000356300.4_Frame_Shift_Del_p.G5fs	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	5					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GTCGAACTTGCCCCCGGGGGA	0.741													2	4	---	---	---	---					
MGA	23269	broad.mit.edu	37	15	42050012	42050012	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:42050012delA	ENST00000219905.7	+	19	7347	c.7166delA	c.(7165-7167)gafs	p.E2389fs	MGA_ENST00000570161.1_Frame_Shift_Del_p.E2389fs|MGA_ENST00000389936.4_Frame_Shift_Del_p.E2350fs|MGA_ENST00000545763.1_Frame_Shift_Del_p.E2180fs|MGA_ENST00000566586.1_Frame_Shift_Del_p.E2180fs	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2350	Helix-loop-helix motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCTGCAGATGAAAAAGCAGCT	0.323													29	48	---	---	---	---					
B2M	567	broad.mit.edu	37	15	45007794	45007797	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr15:45007794_45007797delTCTT	ENST00000558401.1	+	2	311_314	c.241_244delTCTT	c.(241-246)tcfs	p.SF81fs	B2M_ENST00000559916.1_Frame_Shift_Del_p.SF81fs|B2M_ENST00000559220.1_Intron|B2M_ENST00000544417.1_Frame_Shift_Del_p.SF81fs	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	81	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.F82V(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		CAAGGACTGGTCTTTCTATCTCTT	0.431													44	92	---	---	---	---					
ACACA	31	broad.mit.edu	37	17	35445975	35445976	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:35445975_35445976insC	ENST00000353139.5	-	55	7406_7407	c.6925_6926insG	c.(6925-6927)gtgfs	p.V2309fs	ACACA_ENST00000394406.2_Frame_Shift_Ins_p.V2272fs|ACACA_ENST00000360679.3_Frame_Shift_Ins_p.V2214fs|ACACA_ENST00000361253.5_Frame_Shift_Ins_p.V398fs|ACACA_ENST00000335166.5_Frame_Shift_Ins_p.V2194fs	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	2272					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCTAGCCACTCCGCCAGATCC	0.500													27	413	---	---	---	---					
CNTNAP1	8506	broad.mit.edu	37	17	40837068	40837068	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr17:40837068delC	ENST00000264638.4	+	4	640	c.423delC	c.(421-423)ttfs	p.F141fs	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	141	F5/8 type C.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		ACTTCCACTTCACTGCGCGCT	0.617													26	160	---	---	---	---					
THEG	51298	broad.mit.edu	37	19	375963	375964	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr19:375963_375964insC	ENST00000342640.4	-	1	49_50	c.7_8insG	c.(7-9)cagfs	p.Q3fs	THEG_ENST00000346878.2_Frame_Shift_Ins_p.Q3fs	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	3					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCCTGCTGTCCCCCATACAC	0.678													30	83	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41564796	41564796	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chr22:41564796delT	ENST00000263253.7	+	25	5316	c.4097delT	c.(4096-4098)atfs	p.I1366fs		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1366					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTTGAAGAAATTGATGGTGTT	0.493			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				10	137	---	---	---	---					
P2RY8	286530	broad.mit.edu	37	X	1585302	1585302	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:1585302delC	ENST00000381297.4	-	2	360	c.150delG	c.(148-150)cgfs	p.R51fs		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	51						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCCCCATGCGCCGGCACAGCA	0.632			T	CRLF2	"""B-ALL, Downs associated ALL"""								12	29	---	---	---	---					
NLGN4X	57502	broad.mit.edu	37	X	5827137	5827137	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:5827137delC	ENST00000381095.3	-	4	1396	c.769delG	c.(769-771)ccfs	p.A257fs	NLGN4X_ENST00000381092.1_Frame_Shift_Del_p.A257fs|NLGN4X_ENST00000275857.6_Frame_Shift_Del_p.A257fs|NLGN4X_ENST00000538097.1_Frame_Shift_Del_p.A257fs|NLGN4X_ENST00000381093.2_Frame_Shift_Del_p.A277fs	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	257					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						ACACAGGAGGCCCCAGCCCCC	0.572													30	79	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22453780	22453781	+	RNA	INS	-	-	A			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:22453780_22453781insA	ENST00000455399.1	-	0	312				RP11-494I9.2_ENST00000456621.1_RNA																							TGGAATCTGGCATACCTAATTT	0.361													6	10	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578866	154578867	+	RNA	DEL	TT	TT	-			TCGA-69-7974-01A-11D-2184-08	TCGA-69-7974-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be4e197a-9729-4d2f-b508-a3d775deb76e	c000af70-e8a6-435a-b32a-a2ce438e3159	g.chrX:154578866_154578867delTT	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTCTCTCTGTTTTTTTTTTTT	0.421													6	8	---	---	---	---					
