Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OXR1	55074	broad.mit.edu	37	8	107719006	107719006	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:107719006G>T	ENST00000445937.1	+	9	1518	c.1257G>T	c.(1255-1257)atG>atT	p.M419I	OXR1_ENST00000312046.6_Missense_Mutation_p.M412I|OXR1_ENST00000531443.1_Missense_Mutation_p.M419I|OXR1_ENST00000442977.2_Missense_Mutation_p.M420I|OXR1_ENST00000497705.1_Missense_Mutation_p.M352I|OXR1_ENST00000517566.2_Missense_Mutation_p.M419I|OXR1_ENST00000452423.2_5'UTR	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	420					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ATCTTGAAATGGCCATTAAGG	0.343000													28	41					7.65355e-07	9.31694e-07	0.760397	1	0
SLC26A9	115019	broad.mit.edu	37	1	205904929	205904929	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:205904929C>A	ENST00000367135.3	-	2	133	c.20G>T	c.(19-21)cGc>cTc	p.R7L	SLC26A9_ENST00000367134.2_Missense_Mutation_p.R7L|SLC26A9_ENST00000340781.4_Missense_Mutation_p.R7L	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	7						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TACCACGTAGCGGGGCCTGGG	0.577000													18	82					3.51602e-12	5.24754e-12	0.575678	1	0
EPHB4	2050	broad.mit.edu	37	7	100417243	100417243	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100417243C>A	ENST00000358173.3	-	6	1701	c.1233G>T	c.(1231-1233)ggG>ggT	p.G411G	EPHB4_ENST00000360620.3_Silent_p.G411G|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	411	Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGGAGGATACCCCGTTCAATG	0.627000													60	93					1.05635e-38	2.26172e-38	0.870114	1	0
ATP10A	57194	broad.mit.edu	37	15	25940069	25940069	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:25940069G>A	ENST00000356865.6	-	14	3096	c.2985C>T	c.(2983-2985)gcC>gcT	p.A995A		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	995					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGCACTGCTTGGCAAGGAAGA	0.612000													11	28					0	0	0.411799	0	0
COL4A1	1282	broad.mit.edu	37	13	110866335	110866335	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:110866335C>T	ENST00000375820.4	-	3	293	c.172G>A	c.(172-174)Ggt>Agt	p.G58S	COL4A1_ENST00000543140.1_Missense_Mutation_p.G58S	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	58					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAATGACACCTTGTAACCCC	0.537000													853	814					0	0	0.870114	0	0
IGKV1-12	28940	broad.mit.edu	37	2	89339748	89339748	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:89339748G>T	ENST00000480492.1	-	0	370																											GTTGACAATAGTAAGTTGCAA	0.527000													38	194					4.83677e-39	1.03677e-38	0.870114	1	0
AR	367	broad.mit.edu	37	X	66931407	66931407	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:66931407A>T	ENST00000374690.3	+	4	2573	c.2049A>T	c.(2047-2049)ccA>ccT	p.P683P	AR_ENST00000396044.3_Silent_p.P683P|AR_ENST00000396043.2_Silent_p.P151P	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	682	Interaction with MYST2.		G -> A (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CCATTGAGCCAGGTGTAGTGT	0.532000									Androgen Insensitivity Syndrome				8	18					0	0	0.307466	0	0
LAIR1	3903	broad.mit.edu	37	19	54867867	54867867	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:54867867C>A	ENST00000391743.3	-	7	862	c.582G>T	c.(580-582)ctG>ctT	p.L194L	LAIR1_ENST00000474878.1_Silent_p.L194L|LAIR1_ENST00000313038.6_Silent_p.L205L|LAIR1_ENST00000434277.2_Silent_p.L211L|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Silent_p.L195L|LAIR1_ENST00000391742.2_Silent_p.L212L			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	212						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CATCAACAGCCAGGTCAGGCC	0.587000													63	36					5.21738e-30	1.05242e-29	0.870114	1	0
LSS	4047	broad.mit.edu	37	21	47648502	47648502	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:47648502C>A	ENST00000397728.3	-	2	104	c.26G>T	c.(25-27)cGc>cTc	p.R9L	LSS_ENST00000457828.2_5'UTR|LSS_ENST00000356396.4_Missense_Mutation_p.R9L|LSS_ENST00000522411.1_Missense_Mutation_p.R9L|LSS_ENST00000464357.1_5'UTR	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	9					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					GCCCCCTCGGCGCCGCAGACA	0.736000													4	5					0.00024832	0.000273297	0.150653	1	0
TOX2	84969	broad.mit.edu	37	20	42694472	42694472	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:42694472C>A	ENST00000358131.5	+	6	1235	c.1027C>A	c.(1027-1029)Ctg>Atg	p.L343M	TOX2_ENST00000423191.1_Missense_Mutation_p.L319M|TOX2_ENST00000435864.2_Missense_Mutation_p.L239M|TOX2_ENST00000341197.3_Missense_Mutation_p.L361M|TOX2_ENST00000372999.1_Missense_Mutation_p.L319M	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCGTCGGACCTGCAGGCCTT	0.687000													38	100					4.14481e-20	7.45036e-20	0.819951	1	0
CDH7	1005	broad.mit.edu	37	18	63547939	63547939	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:63547939G>T	ENST00000397968.2	+	12	2593	c.2167G>T	c.(2167-2169)Ggt>Tgt	p.G723C	CDH7_ENST00000323011.3_Missense_Mutation_p.G723C	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	723					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TGTTGATCCTGGTGCTCCTCC	0.408000													17	42					3.70931e-20	6.69313e-20	0.539581	1	0
OR52B4	143496	broad.mit.edu	37	11	4389230	4389230	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4389230C>A	ENST00000408920.2	-	1	386	c.296G>T	c.(295-297)tGc>tTc	p.C99F		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGAGTGATGCAACGATCCAG	0.522000													10	51					1.33987e-11	1.95476e-11	0.361761	1	0
LATS1	9113	broad.mit.edu	37	6	150001332	150001332	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:150001332C>A	ENST00000543571.1	-	5	2819	c.2272G>T	c.(2272-2274)Gct>Tct	p.A758S	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Missense_Mutation_p.A758S	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	758	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TCAGCTTCAGCCAGGATATCT	0.373000													40	29					5.78141e-17	9.69752e-17	0.864702	1	0
C5orf30	90355	broad.mit.edu	37	5	102611760	102611760	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:102611760C>A	ENST00000319933.2	+	3	448	c.140C>A	c.(139-141)aCc>aAc	p.T47N	C5orf30_ENST00000515669.1_Missense_Mutation_p.T47N|C5orf30_ENST00000510890.1_Missense_Mutation_p.T47N	NM_033211.2	NP_149988.1	Q96GV9	CE030_HUMAN	chromosome 5 open reading frame 30	47										NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9		all_cancers(142;2.22e-05)|all_epithelial(76;9.54e-08)|Prostate(80;0.0174)|Colorectal(57;0.0551)|Ovarian(225;0.11)|Lung NSC(167;0.136)|all_lung(232;0.18)		Epithelial(69;2.84e-14)|COAD - Colon adenocarcinoma(37;0.00762)		ATGCGGAGGACCGTGTCAGGC	0.602000													88	19					9.62396e-42	2.08187e-41	0.870114	1	0
SLC2A2	6514	broad.mit.edu	37	3	170723830	170723830	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:170723830C>A	ENST00000314251.3	-	6	756	c.677G>T	c.(676-678)gGt>gTt	p.G226V	SLC2A2_ENST00000382808.4_Missense_Mutation_p.G107V	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	226					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GGCTCGCACACCAGACAGGCC	0.413000													39	47					1.00001e-27	1.97898e-27	0.847076	1	0
GATAD2A	54815	broad.mit.edu	37	19	19616192	19616192	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:19616192A>C	ENST00000404158.1	+	14	2232	c.1814A>C	c.(1813-1815)cAc>cCc	p.H605P	GATAD2A_ENST00000429563.2_Missense_Mutation_p.H407P|GATAD2A_ENST00000252577.5_Missense_Mutation_p.H579P|GATAD2A_ENST00000358713.3_Missense_Mutation_p.H604P|GATAD2A_ENST00000360315.3_Missense_Mutation_p.H604P|GATAD2A_ENST00000537887.1_Missense_Mutation_p.H233P			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	604					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						CTGGCGGTGCACAAGAGCTCC	0.647000													20	125					0	0	0.592651	0	0
IL16	3603	broad.mit.edu	37	15	81517912	81517912	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:81517912C>A	ENST00000394660.2	+	2	532	c.172C>A	c.(172-174)Cac>Aac	p.H58N	IL16_ENST00000302987.4_Missense_Mutation_p.H58N	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	58					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GGGAATTTTCCACTCATCTGT	0.542000													26	39					3.86903e-22	7.19517e-22	0.769981	1	0
CACNA1C	775	broad.mit.edu	37	12	2797806	2797806	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:2797806G>T	ENST00000399655.1	+	46	6243	c.5978G>T	c.(5977-5979)gGc>gTc	p.G1993V	CACNA1C_ENST00000399637.1_Missense_Mutation_p.G2012V|CACNA1C_ENST00000335762.5_Missense_Mutation_p.G2018V|CACNA1C_ENST00000399629.1_Missense_Mutation_p.G2010V|CACNA1C_ENST00000347598.4_Missense_Mutation_p.G2041V|CACNA1C_ENST00000344100.3_Missense_Mutation_p.G2034V|CACNA1C_ENST00000399621.1_Missense_Mutation_p.G2012V|CACNA1C_ENST00000399638.1_Missense_Mutation_p.G2021V|CACNA1C_ENST00000406454.3_Missense_Mutation_p.G2064V|CACNA1C_ENST00000402845.3_Missense_Mutation_p.G2012V|CACNA1C_ENST00000399617.1_Missense_Mutation_p.G2028V|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399644.1_Missense_Mutation_p.G1993V|CACNA1C_ENST00000399601.1_Missense_Mutation_p.G1993V|CACNA1C_ENST00000399591.1_Missense_Mutation_p.G2001V|CACNA1C_ENST00000399649.1_Missense_Mutation_p.G1999V|CACNA1C_ENST00000399606.1_Missense_Mutation_p.G2013V|CACNA1C_ENST00000399595.1_Missense_Mutation_p.G2001V|CACNA1C_ENST00000399597.1_Missense_Mutation_p.G1993V|CACNA1C_ENST00000399641.1_Missense_Mutation_p.G1993V|CACNA1C_ENST00000399603.1_Missense_Mutation_p.G1993V|CACNA1C_ENST00000327702.7_Missense_Mutation_p.G2028V|CACNA1C_ENST00000399634.1_Missense_Mutation_p.G2064V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	2076					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATCCACTGCGGCTCCTGGGCT	0.726000													28	25					1.62565e-12	2.43977e-12	0.760397	1	0
FLG	2312	broad.mit.edu	37	1	152282136	152282136	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152282136G>T	ENST00000368799.1	-	3	5261	c.5226C>A	c.(5224-5226)ccC>ccA	p.P1742P	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1742	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGCTGATGGGGCCCAGCCT	0.592000									Ichthyosis				61	454					8.73484e-25	1.6826e-24	0.870114	1	0
VCPKMT	79609	broad.mit.edu	37	14	50583248	50583248	+	Missense_Mutation	SNP	G	G	A	rs144451415		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:50583248G>A	ENST00000395860.2	-	1	27	c.23C>T	c.(22-24)tCg>tTg	p.S8L	METTL21D_ENST00000395859.2_Missense_Mutation_p.S8L	NM_024558.2	NP_078834.2	Q9H867	MT21D_HUMAN		8							methyltransferase activity			kidney(1)|lung(1)|urinary_tract(1)	3						GTCCTCCAGCGAGGACTCCAG	0.652000													16	11					0	0	0.520397	0	0
PTPRS	5802	broad.mit.edu	37	19	5273532	5273532	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:5273532C>G	ENST00000372412.4	-	4	533	c.300G>C	c.(298-300)cgG>cgC	p.R100R	PTPRS_ENST00000588012.1_Silent_p.R100R|PTPRS_ENST00000587303.1_Silent_p.R100R|PTPRS_ENST00000357368.4_Silent_p.R100R|PTPRS_ENST00000353284.2_Silent_p.R100R|PTPRS_ENST00000348075.2_Silent_p.R100R|PTPRS_ENST00000262963.6_Silent_p.R100R|PTPRS_ENST00000590509.1_Silent_p.R100R|PTPRS_ENST00000592099.1_Silent_p.R100R|PTPRS_ENST00000588552.1_5'UTR			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	100	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CGTTTTCATCCCGCGGTGTCC	0.577000													16	71					0	0	0.624587	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434098	22434098	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:22434098G>T	ENST00000390442.3	+	0	207																											CAGCAACAGTGCTTTTCAATA	0.473000													65	58					9.65139e-37	2.0386e-36	0.870114	1	0
APBB1IP	54518	broad.mit.edu	37	10	26789900	26789900	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:26789900A>T	ENST00000376236.4	+	5	768	c.313A>T	c.(313-315)Agt>Tgt	p.S105C	APBB1IP_ENST00000356785.4_Missense_Mutation_p.S105C	NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	105					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						ATCAATTTTCAGTGGTGCAGC	0.473000													44	93					0	0	0.870114	0	0
ZNF285	26974	broad.mit.edu	37	19	44892185	44892185	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:44892185C>G	ENST00000330997.4	-	4	286	c.222G>C	c.(220-222)tgG>tgC	p.W74C	ZNF285_ENST00000544719.2_Missense_Mutation_p.W74C|ZNF285_ENST00000591679.1_Missense_Mutation_p.W81C|CTC-512J12.6_ENST00000588212.1_Intron	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TCCAAATCTGCCAGCAATGAA	0.403000													15	99					0	0	0.500413	0	0
TRIP12	9320	broad.mit.edu	37	2	230670512	230670512	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:230670512T>A	ENST00000283943.5	-	17	2537	c.2359A>T	c.(2359-2361)Aat>Tat	p.N787Y	TRIP12_ENST00000543084.1_Intron|TRIP12_ENST00000389045.3_Missense_Mutation_p.N517Y|TRIP12_ENST00000389044.4_Missense_Mutation_p.N835Y	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	787	WWE.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GTGTCCTCATTGATTTGCTGC	0.423000													9	43					0	0	0.479597	0	0
BAMBI	25805	broad.mit.edu	37	10	28971329	28971329	+	Nonstop_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:28971329G>T	ENST00000375533.3	+	3	1338	c.782G>T	c.(781-783)tGa>tTa	p.*261L		NM_012342.2	NP_036474.1	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	0					cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	17						GAATTCGTATGACGGAGTCTT	0.453000													27	55					7.01153e-11	9.97408e-11	0.717897	1	0
SKOR1	390598	broad.mit.edu	37	15	68124994	68124994	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:68124994G>T	ENST00000380035.2	+	7	2770	c.2712G>T	c.(2710-2712)atG>atT	p.M904I	SKOR1_ENST00000389002.1_Missense_Mutation_p.M860I|SKOR1_ENST00000554054.1_Missense_Mutation_p.M876I|SKOR1_ENST00000341418.5_Missense_Mutation_p.M807I|SKOR1_ENST00000554240.1_Missense_Mutation_p.M865I			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	904					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						GAGAAGAAATGGTGCAACAGC	0.517000											OREG0023215	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	28					4.88482e-21	8.96027e-21	0.870114	1	0
C4orf50	389197	broad.mit.edu	37	4	5966832	5966832	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:5966832G>T	ENST00000531445.1	-	6	1966	c.1920C>A	c.(1918-1920)ctC>ctA	p.L640L	C4orf50_ENST00000324058.5_Silent_p.L166L			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	166										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						ATGAGCTTTGGAGGACACTGT	0.517000													61	37					3.13296e-38	6.69266e-38	0.870114	1	0
OR2M5	127059	broad.mit.edu	37	1	248309179	248309179	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:248309179C>A	ENST00000366476.1	+	1	730	c.730C>A	c.(730-732)Cac>Aac	p.H244N		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	244			H -> N (found in a renal cell carcinoma sample; somatic mutation).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H244N(1)		NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTGTTCCTCTCACCTCATGGT	0.488000													119	203					2.75219e-45	6.02983e-45	0.870114	1	0
CCDC74A	90557	broad.mit.edu	37	2	132290642	132290642	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:132290642G>T	ENST00000295171.6	+	7	1145	c.1007_splice	c.e7+1	p.C336_splice	CCDC74A_ENST00000467992.2_3'UTR|CCDC74A_ENST00000409856.3_Splice_Site_p.C270_splice	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	336										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						TCCAAGAAATGGTAAGTCCCA	0.622000													10	59					1.5842e-08	2.06902e-08	0.435327	1	0
ZNF639	51193	broad.mit.edu	37	3	179051266	179051266	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:179051266C>T	ENST00000326361.3	+	7	959	c.514C>T	c.(514-516)Cca>Tca	p.P172S	ZNF639_ENST00000496856.1_Missense_Mutation_p.P172S|ZNF639_ENST00000466663.1_3'UTR|ZNF639_ENST00000484866.1_Missense_Mutation_p.P172S	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	172					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TGAAGAACCGCCAGCTAAACT	0.418000													17	54					0	0	0.539581	0	0
SGIP1	84251	broad.mit.edu	37	1	67099786	67099786	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:67099786G>T	ENST00000237247.6	+	5	261	c.123G>T	c.(121-123)aaG>aaT	p.K41N	SGIP1_ENST00000468286.1_Intron|SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371037.4_Intron|SGIP1_ENST00000371039.1_Intron			Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	41					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AGACCCAGAAGACTCAGCTTC	0.438000													4	12					0.0215528	0.0222625	0.217242	1	0
OR6V1	346517	broad.mit.edu	37	7	142749967	142749967	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142749967G>T	ENST00000418316.1	+	1	551	c.530G>T	c.(529-531)tGt>tTt	p.C177F		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					CACTTCTTCTGTGACAATGAA	0.542000													62	151					1.39921e-30	2.83762e-30	0.870114	1	0
FAM171B	165215	broad.mit.edu	37	2	187627530	187627530	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:187627530C>T	ENST00000304698.5	+	8	2664	c.2461C>T	c.(2461-2463)Cca>Tca	p.P821S		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	821						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AGAGGAACGCCCACTGATTCC	0.428000													21	39					0	0	0.681144	0	0
RYR2	6262	broad.mit.edu	37	1	237753163	237753163	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237753163C>A	ENST00000366574.2	+	30	3986	c.3669C>A	c.(3667-3669)acC>acA	p.T1223T	RYR2_ENST00000542537.1_Silent_p.T1207T|RYR2_ENST00000360064.6_Silent_p.T1221T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1223	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGTCAGCACCTTGAAATATT	0.428000													7	48					1.76689e-08	2.28857e-08	0.335167	1	0
FAT3	120114	broad.mit.edu	37	11	92532969	92532969	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:92532969C>A	ENST00000298047.6	+	9	6807	c.6790C>A	c.(6790-6792)Ctt>Att	p.L2264I	FAT3_ENST00000409404.2_Missense_Mutation_p.L2264I|FAT3_ENST00000525166.1_Missense_Mutation_p.L2114I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2264	Cadherin 20.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCGACGCCCTTACTGGTGC	0.428000										TCGA Ovarian(4;0.039)			4	13					0.00024832	0.000273297	0.150653	1	0
OASL	8638	broad.mit.edu	37	12	121469249	121469249	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:121469249T>G	ENST00000257570.5	-	3	923	c.653A>C	c.(652-654)cAg>cCg	p.Q218P	OASL_ENST00000339275.5_Missense_Mutation_p.Q218P	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	218					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCTCACCTGCTGGTACCAGTG	0.572000													9	45					0	0	0.335167	0	0
OR5T1	390155	broad.mit.edu	37	11	56043564	56043564	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:56043564C>A	ENST00000313033.2	+	1	536	c.450C>A	c.(448-450)ccC>ccA	p.P150P		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					GCATGTCACCCAGAGTCTATG	0.448000													68	171					2.33925e-33	4.82726e-33	0.870114	1	0
ELMO1	9844	broad.mit.edu	37	7	37172755	37172755	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:37172755G>T	ENST00000310758.4	-	14	1818	c.1171C>A	c.(1171-1173)Cac>Aac	p.H391N	ELMO1_ENST00000448602.1_Missense_Mutation_p.H391N|ELMO1_ENST00000442504.1_Missense_Mutation_p.H391N|ELMO1_ENST00000341056.3_Missense_Mutation_p.H93N	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	391	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						GCATCTTGGTGGTGCTTGGCA	0.453000													17	59					3.32936e-07	4.09265e-07	0.539581	1	0
S1PR1	1901	broad.mit.edu	37	1	101704857	101704857	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:101704857G>T	ENST00000305352.6	+	2	692	c.317G>T	c.(316-318)gGg>gTg	p.G106V	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	106					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CTCTTGTCTGGGGCCACCACC	0.557000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	32					4.59853e-10	6.34489e-10	0.693898	1	0
SLC25A19	60386	broad.mit.edu	37	17	73279629	73279629	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:73279629C>A	ENST00000402418.3	-	3	1243	c.334G>T	c.(334-336)Gtg>Ttg	p.V112L	SLC25A19_ENST00000416858.2_Missense_Mutation_p.V112L|SLC25A19_ENST00000375261.4_Intron|SLC25A19_ENST00000320362.3_Missense_Mutation_p.V112L|SLC25A19_ENST00000442286.2_Missense_Mutation_p.V112L|SLC25A19_ENST00000580994.1_Missense_Mutation_p.V112L			Q9HC21	TPC_HUMAN	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	112						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			GCGTCATACACGCTGCCTCTG	0.562000													15	28					6.49762e-13	9.79849e-13	0.539581	1	0
TMTC2	160335	broad.mit.edu	37	12	83251076	83251076	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:83251076C>A	ENST00000549919.1	+	3	2158	c.353C>A	c.(352-354)gCt>gAt	p.A118D	TMTC2_ENST00000548305.1_Missense_Mutation_p.A124D|TMTC2_ENST00000321196.3_Missense_Mutation_p.A124D			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	124						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						TTGATGTTTGCTTCTCACCCC	0.517000													14	73					6.31663e-08	8.01611e-08	0.479597	1	0
AASDH	132949	broad.mit.edu	37	4	57209774	57209774	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:57209774T>C	ENST00000205214.6	-	13	2909	c.2729A>G	c.(2728-2730)cAt>cGt	p.H910R	AASDH_ENST00000602986.1_Silent_p.S702S|AASDH_ENST00000434343.2_Missense_Mutation_p.H425R|AASDH_ENST00000451613.1_Intron|AASDH_ENST00000513376.1_Missense_Mutation_p.H810R	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	910					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AAAATACAAATGATGTGGAAT	0.313000													128	21					0	0	0.870114	0	0
RBP3	5949	broad.mit.edu	37	10	48389716	48389716	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:48389716G>T	ENST00000224600.4	-	1	1275	c.1162C>A	c.(1162-1164)Cga>Aga	p.R388R		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	388	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCGATGGCTCGCACCAGGAGC	0.647000													6	34					0.00116845	0.00125586	0.217242	1	0
PARD3	56288	broad.mit.edu	37	10	34688331	34688331	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:34688331T>A	ENST00000374789.3	-	7	1142	c.817A>T	c.(817-819)Aag>Tag	p.K273*	PARD3_ENST00000545260.1_Nonsense_Mutation_p.K229*|PARD3_ENST00000374790.3_Nonsense_Mutation_p.K229*|PARD3_ENST00000374794.3_Nonsense_Mutation_p.K229*|PARD3_ENST00000374773.1_Nonsense_Mutation_p.K273*|PARD3_ENST00000350537.4_Nonsense_Mutation_p.K273*|PARD3_ENST00000346874.4_Nonsense_Mutation_p.K273*|PARD3_ENST00000340077.5_Nonsense_Mutation_p.K273*|PARD3_ENST00000374788.3_Nonsense_Mutation_p.K273*|PARD3_ENST00000544292.1_Nonsense_Mutation_p.K3*|PARD3_ENST00000545693.1_Nonsense_Mutation_p.K273*|PARD3_ENST00000374776.1_Nonsense_Mutation_p.K273*	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	273	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TCTACGAGCTTTACCATATCA	0.443000													71	34					0	0	0.870114	0	0
KIF1B	23095	broad.mit.edu	37	1	10384037	10384037	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:10384037G>T	ENST00000377086.1	+	25	2656	c.2454G>T	c.(2452-2454)agG>agT	p.R818S	KIF1B_ENST00000263934.6_Missense_Mutation_p.R772S|KIF1B_ENST00000377081.1_Missense_Mutation_p.R818S			O60333	KIF1B_HUMAN	kinesin family member 1B	818					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ATGAGGACAGGCCTTTCCCTC	0.443000													34	84					1.66425e-11	2.41676e-11	0.804634	1	0
COL5A2	1290	broad.mit.edu	37	2	189943295	189943295	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:189943295C>A	ENST00000374866.3	-	16	1280	c.1005_splice	c.e16-1	p.G336_splice		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	336					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCCTCGGACCCTATAGACGA	0.428000													27	184					6.50621e-10	8.94426e-10	0.769981	1	0
ATP13A5	344905	broad.mit.edu	37	3	193052756	193052756	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:193052756G>A	ENST00000342358.4	-	10	1193	c.1076C>T	c.(1075-1077)tCt>tTt	p.S359F		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	359					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding	p.S359C(1)		NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCCCTGCCCAGAGGGCTTGAC	0.463000													10	94					0	0	0.435327	0	0
OR2M4	26245	broad.mit.edu	37	1	248402744	248402744	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:248402744C>A	ENST00000306687.1	+	1	514	c.514C>A	c.(514-516)Ctg>Atg	p.L172M		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L172V(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGCAGCTCTCTGGAAATTCA	0.438000													15	176					9.16793e-09	1.20321e-08	0.520397	1	0
TACR1	6869	broad.mit.edu	37	2	75276838	75276838	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:75276838G>T	ENST00000305249.4	-	5	1710	c.945C>A	c.(943-945)ggC>ggA	p.G315G		NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	315					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CATGCTTGAAGCCCAGACGGA	0.592000													15	47					2.48551e-13	3.80612e-13	0.520397	1	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276742	71276742	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:71276742G>A	ENST00000398531.1	+	1	134	c.109G>A	c.(109-111)Ggc>Agc	p.G37S	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.G37S	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	37						keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGGCTGTGGGGGCTGTGGCTC	0.697000													35	131					0	0	0.840704	0	0
ATP2B3	492	broad.mit.edu	37	X	152821567	152821567	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:152821567G>T	ENST00000370186.1	+	12	2403	c.2077G>T	c.(2077-2079)Gac>Tac	p.D693Y	ATP2B3_ENST00000349466.2_Missense_Mutation_p.D707Y|ATP2B3_ENST00000370181.2_Missense_Mutation_p.D693Y|ATP2B3_ENST00000263519.4_Missense_Mutation_p.D707Y|ATP2B3_ENST00000359149.3_Missense_Mutation_p.D707Y|ATP2B3_ENST00000393842.1_Missense_Mutation_p.D693Y			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	707					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGACTGGGGACAACATCAA	0.602000													29	170					6.05902e-23	1.14031e-22	0.788014	1	0
AGPAT3	56894	broad.mit.edu	37	21	45391372	45391372	+	Splice_Site	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:45391372G>A	ENST00000398063.2	+	6	1259		c.e6+1		AGPAT3_ENST00000398058.1_Splice_Site|AGPAT3_ENST00000479117.1_Splice_Site|AGPAT3_ENST00000546158.1_Splice_Site|AGPAT3_ENST00000327505.2_Splice_Site|AGPAT3_ENST00000291572.8_Splice_Site|AGPAT3_ENST00000398061.1_Splice_Site	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3						phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		TGTGCGTGAGGTGAGGCCAGA	0.622000													29	64					0	0	0.740014	0	0
SOGA2	23255	broad.mit.edu	37	18	8825006	8825006	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:8825006C>T	ENST00000359865.3	+	15	3640	c.3498C>T	c.(3496-3498)gaC>gaT	p.D1166D	SOGA2_ENST00000306285.7_Silent_p.D491D|SOGA2_ENST00000400050.3_Silent_p.D1125D|SOGA2_ENST00000306329.11_Silent_p.D1485D|SOGA2_ENST00000517570.1_Silent_p.D1125D|SOGA2_ENST00000518815.1_Silent_p.D491D	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1476																	TGACCACGGACACCATGACCA	0.657000													9	77					0	0	0.335167	0	0
ZNF536	9745	broad.mit.edu	37	19	30934776	30934776	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:30934776C>G	ENST00000355537.3	+	2	454	c.307C>G	c.(307-309)Cag>Gag	p.Q103E		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGTGGACTTGCAGCAGTTCCT	0.657000													14	18					0	0	0.500413	0	0
RNASE3	6037	broad.mit.edu	37	14	21360276	21360276	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:21360276G>T	ENST00000304639.3	+	2	489	c.431G>T	c.(430-432)cGg>cTg	p.R144L		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	144					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	AGAGATCCACGGGATTCTCCA	0.483000													32	68					9.04072e-19	1.58129e-18	0.779181	1	0
SEMA3D	223117	broad.mit.edu	37	7	84628806	84628806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:84628806G>A	ENST00000284136.6	-	17	2327	c.2284C>T	c.(2284-2286)Cga>Tga	p.R762*	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	762	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.R762*(1)		NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TGATGTCTTCGATTTCGTTTC	0.453000													15	59					0	0	0.557998	0	0
LIPN	643418	broad.mit.edu	37	10	90524299	90524299	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:90524299G>T	ENST00000404459.1	+	3	359	c.359G>T	c.(358-360)cGg>cTg	p.R120L		NM_001102469.1	NP_001095939.1	Q5VXI9	LIPN_HUMAN	lipase, family member N	120					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|skin(1)	9		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		GGAAACAGTCGGGGAAACACT	0.423000													12	18					1.08611e-07	1.36452e-07	0.387290	1	0
ELAVL4	1996	broad.mit.edu	37	1	50610756	50610756	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:50610756C>T	ENST00000371824.1	+	2	394	c.137C>T	c.(136-138)aCc>aTc	p.T46I	ELAVL4_ENST00000357083.4_Missense_Mutation_p.T63I|ELAVL4_ENST00000371827.1_Missense_Mutation_p.T46I|ELAVL4_ENST00000371819.1_Missense_Mutation_p.T51I|ELAVL4_ENST00000448907.2_Missense_Mutation_p.T49I|ELAVL4_ENST00000371823.4_Missense_Mutation_p.T46I|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371821.1_Missense_Mutation_p.T51I			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	46	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						GACAGCAAAACCAACCTCATC	0.458000													13	40					0	0	0.479597	0	0
ALB	213	broad.mit.edu	37	4	74285969	74285969	+	Splice_Site	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:74285969A>T	ENST00000295897.4	+	14	1874		c.e14-1		ALB_ENST00000503124.1_Splice_Site|ALB_ENST00000401494.3_Splice_Site|ALB_ENST00000415165.2_Splice_Site|ALB_ENST00000509063.1_Intron|ALB_ENST00000505649.1_Splice_Site	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin						bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CTTTGTGTTCAGGGTAAAAAA	0.299000													4	25					0	0	0.184627	0	0
POLRMT	5442	broad.mit.edu	37	19	619607	619607	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:619607C>T	ENST00000588649.2	-	13	3129	c.3045G>A	c.(3043-3045)cgG>cgA	p.R1015R		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	1015	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTCAGCTCCCGGAGGCGCT	0.617000													27	44					0	0	0.681144	0	0
ZNF112	7665	broad.mit.edu	37	19	44833056	44833056	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:44833056G>A	ENST00000354340.4	-	4	1305	c.1254C>T	c.(1252-1254)ttC>ttT	p.F418F	ZNF112_ENST00000337401.4_Silent_p.F424F|ZNF112_ENST00000536500.1_Silent_p.F441F	NM_013380.3	NP_037512.3			zinc finger protein 112																		AACTACAAATGAAACTCTTTC	0.353000													12	47					0	0	0.387290	0	0
ITCH	83737	broad.mit.edu	37	20	33065629	33065629	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:33065629C>T	ENST00000374864.4	+	17	1835	c.1622C>T	c.(1621-1623)cCa>cTa	p.P541L	ITCH_ENST00000535650.1_Missense_Mutation_p.P431L|ITCH_ENST00000262650.6_Missense_Mutation_p.P582L|ITCH_ENST00000483727.1_3'UTR	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	582					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GTGATTTTTCCAGGAGAAGAA	0.363000													33	102					0	0	0.847076	0	0
HTR2C	3358	broad.mit.edu	37	X	113965830	113965830	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:113965830T>G	ENST00000276198.1	+	4	891	c.163T>G	c.(163-165)Tgg>Ggg	p.W55G	HTR2C_ENST00000371951.1_Missense_Mutation_p.W55G|HTR2C_ENST00000371950.3_Missense_Mutation_p.W55G	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	55					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity	p.W55R(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GGTACAAAACTGGCCAGCACT	0.438000													28	97					0	0	0.740014	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502475	90502475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:90502475C>T	ENST00000325643.5	+	4	3139	c.3073C>T	c.(3073-3075)Cag>Tag	p.Q1025*		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CATAGGGTCCCAGTGGGCAAG	0.592000													10	46					0	0	0.335167	0	0
PTCHD2	57540	broad.mit.edu	37	1	11577576	11577576	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:11577576G>T	ENST00000294484.6	+	7	1944	c.1806G>T	c.(1804-1806)tgG>tgT	p.W602C	PTCHD2_ENST00000389575.3_Missense_Mutation_p.W602C	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	602	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTGTTGCTGGCTGGCCGTGC	0.607000													69	73					5.29152e-50	1.17161e-49	0.870114	1	0
SFRP1	6422	broad.mit.edu	37	8	41166587	41166587	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:41166587G>T	ENST00000220772.3	-	1	429	c.92C>A	c.(91-93)gCc>gAc	p.A31D		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	31					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GTACTCGCTGGCCGAGCCCAC	0.726000													7	9					0.00307968	0.00327455	0.278610	1	0
C9	735	broad.mit.edu	37	5	39341729	39341729	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:39341729C>A	ENST00000263408.4	-	3	352	c.257G>T	c.(256-258)cGa>cTa	p.R86L	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	86	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CACACACTGTCGTCTGTCTCC	0.453000													13	21					2.31682e-05	2.6474e-05	0.479597	1	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657742	72657742	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:72657742C>A	ENST00000425256.1	-	0	2169					NR_002164.1																						gaaagtgggccagattattcc	0.493000													24	219					8.4185e-14	1.30723e-13	0.760397	1	0
KCNC2	3747	broad.mit.edu	37	12	75601332	75601332	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:75601332G>C	ENST00000549446.1	-	2	1112	c.432C>G	c.(430-432)gaC>gaG	p.D144E	KCNC2_ENST00000540018.1_Missense_Mutation_p.D144E|KCNC2_ENST00000341669.3_Missense_Mutation_p.D144E|KCNC2_ENST00000548513.1_Missense_Mutation_p.D144E|KCNC2_ENST00000550433.1_Missense_Mutation_p.D144E|KCNC2_ENST00000393288.2_Missense_Mutation_p.D144E|KCNC2_ENST00000350228.2_Missense_Mutation_p.D144E|KCNC2_ENST00000298972.1_Missense_Mutation_p.D144E	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	144					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CGTCGGTCTCGTCGATGCCCC	0.667000													20	17					0	0	0.608945	0	0
MST1	4485	broad.mit.edu	37	3	49723312	49723312	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:49723312C>A	ENST00000449682.2	-	10	1592	c.1231G>T	c.(1231-1233)Gag>Tag	p.E411*	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	397	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCGGCGTCTCAGCGGACCAG	0.701000													14	156					5.03518e-11	7.21722e-11	0.557998	1	0
IGSF21	84966	broad.mit.edu	37	1	18554453	18554453	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:18554453G>T	ENST00000251296.1	+	2	515	c.132G>T	c.(130-132)ttG>ttT	p.L44F		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	44	Ig-like 1.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCGTGACTTTGAAGTGTAACT	0.572000													41	83					3.50607e-19	6.16099e-19	0.870114	1	0
WWP1	11059	broad.mit.edu	37	8	87414324	87414324	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:87414324T>A	ENST00000517970.1	+	8	923	c.616T>A	c.(616-618)Tat>Aat	p.Y206N	WWP1_ENST00000341922.2_Intron|WWP1_ENST00000265428.4_Missense_Mutation_p.Y206N|WWP1_ENST00000349423.2_Intron	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	206					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						ATGCTGCTCGTATGTAGTTAA	0.448000													25	74					0	0	0.760397	0	0
GFRAL	389400	broad.mit.edu	37	6	55223780	55223780	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:55223780G>T	ENST00000340465.2	+	6	882	c.796G>T	c.(796-798)Gac>Tac	p.D266Y		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	266						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAGCAAACAGGACCTCACTTG	0.443000													81	145					9.01214e-43	1.95627e-42	0.870114	1	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849544	98849544	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:98849544G>T	ENST00000554295.1	-	0	1379					NR_033801.1																						GGTAGATATGGGCGGCTCTGC	0.498000													12	20					4.3838e-07	5.36431e-07	0.435327	1	0
POSTN	10631	broad.mit.edu	37	13	38162064	38162064	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:38162064A>G	ENST00000379747.4	-	5	618	c.501T>C	c.(499-501)agT>agC	p.S167S	POSTN_ENST00000379742.4_Silent_p.S167S|POSTN_ENST00000541179.1_Silent_p.S167S|POSTN_ENST00000379749.4_Silent_p.S167S|POSTN_ENST00000379743.4_Silent_p.S167S|POSTN_ENST00000541481.1_Silent_p.S167S	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	167	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TAATCATGTGACTATGTAAAG	0.323000													17	49					0	0	0.500413	0	0
EYS	346007	broad.mit.edu	37	6	66094311	66094311	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:66094311C>T	ENST00000503581.1	-	8	1804	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	EYS_ENST00000370621.3_Missense_Mutation_p.E423K|EYS_ENST00000370618.3_Missense_Mutation_p.E423K|EYS_ENST00000342421.5_Missense_Mutation_p.E423K|EYS_ENST00000393380.2_Missense_Mutation_p.E423K|EYS_ENST00000370616.2_Missense_Mutation_p.E423K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	423					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						AAACACCATTCTTCATTCAGA	0.323000													10	50					0	0	0.435327	0	0
OR10G8	219869	broad.mit.edu	37	11	123900867	123900867	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:123900867G>C	ENST00000431524.1	+	1	571	c.538G>C	c.(538-540)Gca>Cca	p.A180P		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TTTGTGTGATGCACCGCCCAT	0.522000													84	135					0	0	0.870114	0	0
MYH6	4624	broad.mit.edu	37	14	23872558	23872558	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:23872558C>A	ENST00000405093.3	-	10	967	c.898_splice	c.e10+1	p.L299_splice	MYH6_ENST00000356287.3_Splice_Site_p.L299_splice	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	299	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CAGGTTCACCCAGCAACTCCG	0.607000													105	259					9.44517e-67	2.13139e-66	0.870114	1	0
OR2M2	391194	broad.mit.edu	37	1	248343719	248343719	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:248343719G>T	ENST00000359682.2	+	1	432	c.432G>T	c.(430-432)atG>atT	p.M144I		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M144I(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGGACTTATGGCTACCTTCT	0.423000													76	294					1.5608e-48	3.45173e-48	0.870114	1	0
INPP5B	3633	broad.mit.edu	37	1	38331516	38331516	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:38331516C>A	ENST00000373023.2	-	22	2764	c.2671G>T	c.(2671-2673)Gag>Tag	p.E891*	INPP5B_ENST00000373027.1_Nonsense_Mutation_p.E647*|INPP5B_ENST00000373024.3_Nonsense_Mutation_p.E811*|INPP5B_ENST00000373026.1_Nonsense_Mutation_p.E891*	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	891	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGAAGGCTCTCCAGGAAAAGC	0.498000													22	37					2.89027e-11	4.15863e-11	0.624587	1	0
NAP1L3	4675	broad.mit.edu	37	X	92927450	92927450	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:92927450G>T	ENST00000373079.3	-	1	1117	c.854C>A	c.(853-855)cCt>cAt	p.P285H	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	285					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						CCTTTCCTCAGGAACTCTTTT	0.448000													13	21					4.14922e-12	6.15838e-12	0.500413	1	0
ROBO3	64221	broad.mit.edu	37	11	124748657	124748657	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:124748657C>A	ENST00000397801.1	+	23	3690	c.3498C>A	c.(3496-3498)ccC>ccA	p.P1166P	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000543966.1_5'UTR|ROBO3_ENST00000538940.1_Silent_p.P1144P	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1166					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTCCCCAGCCCCCAACTGACA	0.552000													23	48					3.1745e-13	4.84542e-13	0.729181	1	0
KIAA1586	57691	broad.mit.edu	37	6	56918819	56918819	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:56918819C>A	ENST00000370733.4	+	4	1729	c.1522C>A	c.(1522-1524)Cat>Aat	p.H508N	KIAA1586_ENST00000545356.1_Missense_Mutation_p.H481N	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	508							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GCATTTTTCTCATTCTTACTC	0.358000													10	104					2.27111e-07	2.82127e-07	0.411799	1	0
SERPINB3	6317	broad.mit.edu	37	18	61323258	61323258	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:61323258C>T	ENST00000283752.5	-	8	949	c.806G>A	c.(805-807)tGg>tAg	p.W269*	SERPINB3_ENST00000332821.8_Nonsense_Mutation_p.W217*|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	269					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CAAACTTGTCCATTCCATCAA	0.383000													12	15					0	0	0.520397	0	0
PKDCC	91461	broad.mit.edu	37	2	42281215	42281215	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:42281215C>T	ENST00000294964.5	+	3	982	c.802C>T	c.(802-804)Cac>Tac	p.H268Y		NM_138370.2	NP_612379.2	Q504Y2	PKDCC_HUMAN	protein kinase domain containing, cytoplasmic	268	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(2)|kidney(1)|lung(5)	8						CCACCTGGCCCACTCCCCACT	0.622000													7	64					0	0	0.307466	0	0
ELMO2	63916	broad.mit.edu	37	20	45002998	45002998	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:45002998A>G	ENST00000372176.1	-	15	1456	c.988T>C	c.(988-990)Tgt>Cgt	p.C330R	ELMO2_ENST00000454865.2_Missense_Mutation_p.C150R|ELMO2_ENST00000396391.1_Missense_Mutation_p.C418R|ELMO2_ENST00000352077.2_Missense_Mutation_p.C416R|ELMO2_ENST00000290246.6_Missense_Mutation_p.C418R|ELMO2_ENST00000439931.2_Missense_Mutation_p.C430R|ELMO2_ENST00000445496.2_Missense_Mutation_p.C235R			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	418	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				AGGATTTCACAGAGCATTTTG	0.483000													32	69					0	0	0.804634	0	0
CDH16	1014	broad.mit.edu	37	16	66943246	66943246	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:66943246G>T	ENST00000299752.4	-	17	2509	c.2316C>A	c.(2314-2316)cgC>cgA	p.R772R	CDH16_ENST00000570262.1_Silent_p.R692R|CDH16_ENST00000565796.1_Silent_p.R733R|CDH16_ENST00000568632.1_Silent_p.R675R|CDH16_ENST00000394055.3_Silent_p.R750R	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	772	Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GGCCCACCTTGCGCATGCACT	0.617000													16	9					0.000175454	0.000194238	0.592651	1	0
KIF20B	9585	broad.mit.edu	37	10	91477354	91477354	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:91477354T>C	ENST00000416354.1	+	11	1218	c.1146T>C	c.(1144-1146)gcT>gcC	p.A382A	KIF20B_ENST00000371728.3_Silent_p.A382A|KIF20B_ENST00000260753.4_Silent_p.A382A|KIF20B_ENST00000394289.2_Silent_p.A382A			Q96Q89	KI20B_HUMAN	kinesin family member 20B	382	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						GTGATCTTGCTGGTTCAGAAC	0.289000													19	38					0	0	0.575678	0	0
PARP14	54625	broad.mit.edu	37	3	122422783	122422783	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:122422783G>T	ENST00000474629.2	+	7	3542	c.3276G>T	c.(3274-3276)gtG>gtT	p.V1092V		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1092	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TGCTTCACGTGGTAGCTCCGG	0.512000													106	128					1.48212e-80	3.38512e-80	0.870114	1	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011404	46011404	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:46011404G>C	ENST00000400368.1	-	1	982	c.962C>G	c.(961-963)cCc>cGc	p.P321R	TSPEAR_ENST00000323084.4_Intron	NM_198688.2	NP_941961.2	P60371	KR106_HUMAN	keratin associated protein 10-6	321	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						ACCACAGGAGGGGACGGGCAC	0.701000													39	100					0	0	0.870114	0	0
SYT11	23208	broad.mit.edu	37	1	155838522	155838522	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:155838522G>C	ENST00000368324.4	+	2	1054	c.801G>C	c.(799-801)ggG>ggC	p.G267G	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	267						cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CACTGGCAGGGGTGGACCCCA	0.557000													12	72					0	0	0.411799	0	0
CENPF	1063	broad.mit.edu	37	1	214819355	214819355	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:214819355G>T	ENST00000366955.3	+	13	6610	c.6442G>T	c.(6442-6444)Gag>Tag	p.E2148*		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2244	Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ACGCGAGCGGGAGAATGATTC	0.458000													33	41					2.19358e-23	4.14906e-23	0.812448	1	0
ABCB1	5243	broad.mit.edu	37	7	87174223	87174223	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:87174223G>T	ENST00000265724.3	-	17	2397	c.1980C>A	c.(1978-1980)tcC>tcA	p.S660S	ABCB1_ENST00000543898.1_Silent_p.S596S	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	660					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTATTAGACTGGATCTTGAAT	0.393000													47	43					2.27781e-18	3.94373e-18	0.870114	1	0
PAPD7	11044	broad.mit.edu	37	5	6738809	6738809	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:6738809G>T	ENST00000230859.6	+	3	233	c.104G>T	c.(103-105)gGc>gTc	p.G35V		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	35					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CAGATATTTGGCAGCTTTAGT	0.438000													35	309					1.57019e-19	2.79047e-19	0.834066	1	0
OR5I1	10798	broad.mit.edu	37	11	55703782	55703782	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55703782A>T	ENST00000301532.3	-	1	94	c.95T>A	c.(94-96)aTg>aAg	p.M32K		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TGTCAGAAACATGAGGAACAG	0.393000													23	60					0	0	0.706142	0	0
SLC32A1	140679	broad.mit.edu	37	20	37353602	37353602	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:37353602G>T	ENST00000217420.1	+	1	498	c.235G>T	c.(235-237)Gtc>Ttc	p.V79F		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	79					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGAAGCGCCCGTCGAGGGAGA	0.667000													12	20					5.50884e-06	6.43952e-06	0.411799	1	0
HSP90AB1	3326	broad.mit.edu	37	6	44217272	44217272	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:44217272G>T	ENST00000371554.1	+	3	520	c.306G>T	c.(304-306)ttG>ttT	p.L102F	HSP90AB1_ENST00000353801.3_Missense_Mutation_p.L102F|HSP90AB1_ENST00000371646.5_Missense_Mutation_p.L102F			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	102					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TAAATAATTTGGGAACCATTG	0.428000													9	83					6.40141e-05	7.20973e-05	0.387290	1	0
AHNAK2	113146	broad.mit.edu	37	14	105411103	105411103	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:105411103G>A	ENST00000333244.5	-	7	10804	c.10685C>T	c.(10684-10686)cCc>cTc	p.P3562L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3562						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTTTAAACTGGGCATCTCCAC	0.617000													19	230					0	0	0.592651	0	0
LAMC1	3915	broad.mit.edu	37	1	183101554	183101554	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:183101554G>A	ENST00000258341.4	+	21	3843	c.3586G>A	c.(3586-3588)Gac>Aac	p.D1196N		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1196	Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAAGCTGATGACATTGTTCG	0.383000													19	71					0	0	0.608945	0	0
GREB1	9687	broad.mit.edu	37	2	11738002	11738002	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:11738002C>T	ENST00000381486.2	+	14	2350	c.2050C>T	c.(2050-2052)Caa>Taa	p.Q684*	GREB1_ENST00000234142.5_Nonsense_Mutation_p.Q684*	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	684						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TTCCAGCACCCAAAATCTGGA	0.542000													110	119					0	0	0.870114	0	0
SLC12A9	56996	broad.mit.edu	37	7	100454619	100454619	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100454619C>T	ENST00000354161.3	+	5	703	c.578C>T	c.(577-579)tCa>tTa	p.S193L	SLC12A9_ENST00000415287.1_Missense_Mutation_p.S104L|SLC12A9_ENST00000428758.1_Missense_Mutation_p.S193L|SLC12A9_ENST00000540482.1_Missense_Mutation_p.S193L|SLC12A9_ENST00000275729.3_Missense_Mutation_p.S104L	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	193						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCCCGGGCCTCATTCCTCACA	0.652000													17	119					0	0	0.575678	0	0
TRAV6	6956	broad.mit.edu	37	14	22237167	22237167	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:22237167G>T	ENST00000390428.3	+	0	251																											TCCAGGAAGAGGCCCTGTTTT	0.443000													10	34					9.70103e-10	1.32204e-09	0.361761	1	0
FLG	2312	broad.mit.edu	37	1	152280902	152280902	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152280902G>A	ENST00000368799.1	-	3	6495	c.6460C>T	c.(6460-6462)Caa>Taa	p.Q2154*	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2154	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGCTCTTGGTGGGACCCC	0.597000									Ichthyosis				165	507					0	0	0.870114	0	0
FAM117B	150864	broad.mit.edu	37	2	203590985	203590985	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:203590985C>A	ENST00000303116.6	+	4	869	c.127C>A	c.(127-129)Cgc>Agc	p.R43S	FAM117B_ENST00000392238.2_Missense_Mutation_p.R287S	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	287	Gly-rich.									breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						TGCAAAATTACGCCAGCAGTT	0.388000													24	63					7.41945e-09	9.78515e-09	0.693898	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84606797	84606797	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:84606797G>T	ENST00000344803.2	+	4	1459	c.1412G>T	c.(1411-1413)tGg>tTg	p.W471L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TTTCCTTTTTGGGCCAGTAAA	0.418000													10	32					0.00010058	0.000112073	0.411799	1	0
RET	5979	broad.mit.edu	37	10	43615061	43615061	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:43615061C>A	ENST00000355710.3	+	14	2707	c.2475C>A	c.(2473-2475)ggC>ggA	p.G825G	RET_ENST00000340058.5_Silent_p.G825G	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	825	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TGGGGCCTGGCTACCTGGGCA	0.672000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				9	21					0.0581538	0.0595135	0.335167	1	0
NUTM1	256646	broad.mit.edu	37	15	34640599	34640599	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:34640599G>T	ENST00000537011.1	+	3	912	c.530G>T	c.(529-531)gGt>gTt	p.G177V	NUTM1_ENST00000333756.4_Missense_Mutation_p.G149V|NUTM1_ENST00000438749.3_Missense_Mutation_p.G167V					NUT midline carcinoma, family member 1																		AAGGCTGTTGGTGTCAGCCAG	0.602000													4	10					0.184627	0.18651	0.184627	1	0
GP6	51206	broad.mit.edu	37	19	55525920	55525920	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55525920C>A	ENST00000310373.3	-	8	1420	c.1393G>T	c.(1393-1395)Gtt>Ttt	p.V465F	GP6_ENST00000333884.2_3'UTR|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000417454.1_3'UTR	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	121					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GAGGATGGAACAGAGTCAACC	0.532000													24	78					8.24728e-16	1.34501e-15	0.681144	1	0
NLRP13	126204	broad.mit.edu	37	19	56424028	56424028	+	Silent	SNP	C	C	A	rs150664866	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:56424028C>A	ENST00000588751.1	-	5	1179	c.1155G>T	c.(1153-1155)ggG>ggT	p.G385G	NLRP13_ENST00000342929.3_Silent_p.G385G			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	385	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CCCCTGTGAACCCTGTAATTT	0.428000													155	38					9.97002e-88	2.2799e-87	0.870114	1	0
CPXCR1	53336	broad.mit.edu	37	X	88008836	88008836	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:88008836C>A	ENST00000276127.4	+	3	680	c.421C>A	c.(421-423)Cca>Aca	p.P141T	CPXCR1_ENST00000373111.1_Missense_Mutation_p.P141T	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	141						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						ATGGAGAGTCCCATTTATTAA	0.388000													5	9					0.00116845	0.00125586	0.217242	1	0
IKBKAP	8518	broad.mit.edu	37	9	111640998	111640998	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:111640998C>A	ENST00000374647.5	-	34	3912	c.3605G>T	c.(3604-3606)cGg>cTg	p.R1202L	IKBKAP_ENST00000537196.1_Missense_Mutation_p.R853L	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	1202					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GTGCTTCTTCCGCTCCGCTTT	0.498000													77	143					5.56462e-29	1.11648e-28	0.870114	1	0
TRBV7-4	28594	broad.mit.edu	37	7	142176611	142176611	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142176611C>A	ENST00000390369.2	-	0	64																											CTGGGAGACTCCAGCACCTGT	0.448000													3	36					2.56e-06	3.05318e-06	0.150653	1	0
GPRASP2	114928	broad.mit.edu	37	X	101971043	101971043	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:101971043G>T	ENST00000543253.1	+	5	2165	c.1246G>T	c.(1246-1248)Ggg>Tgg	p.G416W	GPRASP2_ENST00000535209.1_Missense_Mutation_p.G416W|GPRASP2_ENST00000332262.5_Missense_Mutation_p.G416W	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						AACTGAGGAGGGGGCCATTGG	0.557000													13	144					1.67942e-08	2.1858e-08	0.539581	1	0
CDH6	1004	broad.mit.edu	37	5	31294321	31294321	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:31294321A>G	ENST00000265071.2	+	3	746	c.481A>G	c.(481-483)Aag>Gag	p.K161E	CDH6_ENST00000514738.1_Missense_Mutation_p.K106E	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	161	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AATATTCACCAAGGAGGTTTA	0.478000													23	236					0	0	0.706142	0	0
CADM3	57863	broad.mit.edu	37	1	159163779	159163779	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:159163779G>A	ENST00000368125.4	+	5	797	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	CADM3_ENST00000368124.4_Missense_Mutation_p.E248K	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	214	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.E248Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					TGTGAACCATGAATCTCTAAA	0.498000													4	85					0	0	0.184627	0	0
DEFB113	245927	broad.mit.edu	37	6	49937287	49937287	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:49937287G>T	ENST00000398718.1	-	1	51	c.52C>A	c.(52-54)Cca>Aca	p.P18T		NM_001037729.1	NP_001032818.1	Q30KQ7	DB113_HUMAN	defensin, beta 113	18					defense response to bacterium	extracellular region				breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Lung NSC(77;0.042)					TTACCTGATGGACCACAAGAC	0.303000													18	41					7.41877e-09	9.78515e-09	0.608945	1	0
SNHG14	104472715	broad.mit.edu	37	15	25468328	25468328	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:25468328C>A	ENST00000453082.2	+	0	876					NR_003343.1																						GTCTCCTGAACTGAGCTGTGG	0.577000													11	24					3.07112e-06	3.6397e-06	0.387290	1	0
RAB40AL	282808	broad.mit.edu	37	X	102192279	102192279	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:102192279C>T	ENST00000218249.5	+	1	80	c.33C>T	c.(31-33)taC>taT	p.Y11Y		NM_001031834.1	NP_001027004.1	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	11					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(3)	12						ACCAGGCCTACGACTTCCTGC	0.692000													20	100					0	0	0.592651	0	0
SFRP4	6424	broad.mit.edu	37	7	37951859	37951859	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:37951859A>T	ENST00000436072.2	-	4	1030	c.653T>A	c.(652-654)gTg>gAg	p.V218E	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	218	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TTTTACATCCACCACCGTTGT	0.428000													31	79					0	0	0.779181	0	0
PRRX1	5396	broad.mit.edu	37	1	170695527	170695527	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:170695527C>A	ENST00000239461.6	+	3	897	c.584C>A	c.(583-585)aCa>aAa	p.T195K	PRRX1_ENST00000367760.3_Missense_Mutation_p.T195K|PRRX1_ENST00000497230.2_Missense_Mutation_p.T195K|PRRX1_ENST00000476867.2_3'UTR	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	195						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCCTGGGGGACAGCGTCTCCG	0.572000													24	108					8.53417e-09	1.12474e-08	0.769981	1	0
KCNC4	3749	broad.mit.edu	37	1	110754526	110754526	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:110754526C>G	ENST00000369787.3	+	1	432	c.405C>G	c.(403-405)atC>atG	p.I135M	KCNC4_ENST00000438661.2_Missense_Mutation_p.I135M|KCNC4_ENST00000413138.3_Missense_Mutation_p.I135M	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	135					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCTGGGGCATCGACGAGACCG	0.667000													6	67					0	0	0.248553	0	0
KSR2	283455	broad.mit.edu	37	12	117968769	117968769	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:117968769C>A	ENST00000425217.1	-	12	1746	c.1692G>T	c.(1690-1692)ctG>ctT	p.L564L	KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000339824.5_Silent_p.L593L|KSR2_ENST00000302438.5_Silent_p.L290L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	593					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCACCGGATGCAGGATGACCT	0.552000													23	99					2.08457e-15	3.3474e-15	0.750413	1	0
SLC44A5	204962	broad.mit.edu	37	1	75681449	75681449	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:75681449G>T	ENST00000370855.5	-	19	1831	c.1718C>A	c.(1717-1719)gCc>gAc	p.A573D	SLC44A5_ENST00000370859.3_Missense_Mutation_p.A573D|SLC44A5_ENST00000535611.1_Missense_Mutation_p.A443D	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	573						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						CATAATATAGGCATTTCTGTT	0.358000													16	26					5.3912e-06	6.33744e-06	0.539581	1	0
LAMA1	284217	broad.mit.edu	37	18	6950865	6950865	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:6950865G>T	ENST00000389658.3	-	58	8406	c.8313C>A	c.(8311-8313)ggC>ggA	p.G2771G		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2771	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGGAGGCGGCCCCCGTGCA	0.572000													27	22					1.88708e-17	3.19379e-17	0.729181	1	0
TRPV5	56302	broad.mit.edu	37	7	142612722	142612722	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142612722C>A	ENST00000265310.1	-	9	1487	c.1139G>T	c.(1138-1140)cGt>cTt	p.R380L		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	380					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GATATCTTCACGTGTCTCATA	0.532000													17	40					0.000175454	0.000194238	0.592651	1	0
FZD8	8325	broad.mit.edu	37	10	35929556	35929556	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:35929556A>G	ENST00000374694.1	-	1	806	c.802T>C	c.(802-804)Ttt>Ctt	p.F268L		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	268					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						TGGCTGAAAAAGGGGTTGTGG	0.637000													3	68					0	0	0.150653	0	0
LILRB1	10859	broad.mit.edu	37	19	55145107	55145107	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55145107G>C	ENST00000396331.1	+	9	1637	c.1280G>C	c.(1279-1281)aGc>aCc	p.S427T	LILRB1_ENST00000396321.2_Missense_Mutation_p.S427T|LILRB1_ENST00000396327.3_Missense_Mutation_p.S427T|LILRB1_ENST00000396332.4_Missense_Mutation_p.S427T|LILRB1_ENST00000396317.1_Intron|LILRB1_ENST00000396315.1_Missense_Mutation_p.S427T|LILRB1_ENST00000448689.1_Missense_Mutation_p.S427T|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000427581.2_Missense_Mutation_p.S463T|LILRB1_ENST00000324602.7_Missense_Mutation_p.S427T|LILRB1_ENST00000434867.2_Missense_Mutation_p.S427T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	427					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GGGGGCCCCAGCTCCCCGACA	0.607000										HNSCC(37;0.09)			23	25					0	0	0.769981	0	0
OR10K2	391107	broad.mit.edu	37	1	158390621	158390621	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158390621G>T	ENST00000314902.2	-	1	35	c.36C>A	c.(34-36)gtC>gtA	p.V12V		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CGAGGAAGATGACCTCTCTCA	0.512000													12	229					1.5842e-08	2.06902e-08	0.435327	1	0
PRRC2B	84726	broad.mit.edu	37	9	134334683	134334683	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:134334683G>C	ENST00000357304.4	+	10	1399	c.1344G>C	c.(1342-1344)gcG>gcC	p.A448A	PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Silent_p.A448A|PRRC2B_ENST00000405995.1_Silent_p.A448A	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	448							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						TCCGAAAGGCGCCAGACCCTC	0.607000													14	20					0	0	0.457914	0	0
TMEM55A	55529	broad.mit.edu	37	8	92030695	92030695	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:92030695G>T	ENST00000285419.3	-	4	723	c.409C>A	c.(409-411)Caa>Aaa	p.Q137K	GS1-251I9.3_ENST00000517920.1_RNA	NM_018710.2	NP_061180.1	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	137						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	13			BRCA - Breast invasive adenocarcinoma(11;0.033)			TGAGCTGGTTGTTCTTCAGAA	0.448000													58	122					4.13886e-29	8.31306e-29	0.870114	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685959	125685959	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:125685959G>A	ENST00000371126.1	-	1	875	c.633C>T	c.(631-633)ggC>ggT	p.G211G		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	211										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CGTCGCGGGAGCCGCTCACGG	0.657000													6	28					0	0	0.307466	0	0
PTPRD	5789	broad.mit.edu	37	9	8338979	8338979	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:8338979C>A	ENST00000381196.4	-	40	5865	c.5322G>T	c.(5320-5322)atG>atT	p.M1774I	PTPRD_ENST00000540109.1_Missense_Mutation_p.M1774I|PTPRD_ENST00000358503.5_Missense_Mutation_p.M1752I|PTPRD_ENST00000537002.1_Missense_Mutation_p.M1364I|PTPRD_ENST00000356435.5_Missense_Mutation_p.M1774I|PTPRD_ENST00000486161.1_Missense_Mutation_p.M1367I|PTPRD_ENST00000360074.4_Missense_Mutation_p.M1761I|PTPRD_ENST00000397606.3_Missense_Mutation_p.M1367I|PTPRD_ENST00000397617.3_Missense_Mutation_p.M1367I|PTPRD_ENST00000355233.5_Missense_Mutation_p.M1368I|PTPRD_ENST00000397611.3_Missense_Mutation_p.M1364I	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1774	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGTACTCAGCCATGGGATCTA	0.423000										TSP Lung(15;0.13)			32	112					5.71845e-15	9.10501e-15	0.812448	1	0
TENM3	55714	broad.mit.edu	37	4	183594351	183594351	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:183594351C>A	ENST00000511685.1	+	7	1428	c.1305C>A	c.(1303-1305)ggC>ggA	p.G435G	TENM3_ENST00000406950.2_Silent_p.G435G					teneurin transmembrane protein 3																		GCCGGAAAGGCTTACCGCCTT	0.383000													9	13					4.3838e-07	5.36431e-07	0.435327	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873778	91873778	+	Nonsense_Mutation	SNP	G	G	T	rs3813174	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:91873778G>T	ENST00000373094.1	+	7	4728	c.3883G>T	c.(3883-3885)Gga>Tga	p.G1295*	PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.G1277*|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.G1258*|PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.G1285*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.G1258*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.G1287*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1295					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGTTGATCAGGGAGTGCAAGG	0.473000													53	169					1.84395e-34	3.82193e-34	0.870114	1	0
KMT2C	58508	broad.mit.edu	37	7	151970792	151970792	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:151970792C>A	ENST00000355193.2	-	7	1228	c.1010G>T	c.(1009-1011)aGa>aTa	p.R337I	KMT2C_ENST00000262189.6_Missense_Mutation_p.R337I					lysine (K)-specific methyltransferase 2C																		AAACTTACATCTTTCAGGAGC	0.373000													20	209					4.4004e-07	5.38113e-07	0.654019	1	0
ACACB	32	broad.mit.edu	37	12	109670472	109670472	+	Splice_Site	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:109670472A>G	ENST00000338432.7	+	29	4120		c.e29-1		ACACB_ENST00000377854.5_Splice_Site|ACACB_ENST00000377848.3_Splice_Site			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta						acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	ATCACCTTACAGGATGACCGT	0.577000													23	62					0	0	0.729181	0	0
TMED10	10972	broad.mit.edu	37	14	75602490	75602490	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:75602490T>C	ENST00000303575.4	-	4	562	c.511A>G	c.(511-513)Aga>Gga	p.R171G	TMED10_ENST00000557670.1_5'UTR|RP11-950C14.7_ENST00000556236.1_RNA	NM_006827.5	NP_006818.3	P49755	TMEDA_HUMAN	transmembrane emp24-like trafficking protein 10 (yeast)	171	GOLD.				protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding			endometrium(1)|large_intestine(5)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(234;0.0126)		TCCTCTTCTCTCTTCTTCATG	0.433000													14	59					0	0	0.557998	0	0
SALL1	6299	broad.mit.edu	37	16	51173792	51173792	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:51173792G>T	ENST00000440970.1	-	2	2481	c.2050C>A	c.(2050-2052)Ctg>Atg	p.L684M	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.L781M	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	781					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGCTGCTGCAGGACCACAGCG	0.552000													29	29					2.42023e-17	4.08509e-17	0.779181	1	0
FOXN4	121643	broad.mit.edu	37	12	109717564	109717564	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:109717564G>T	ENST00000299162.5	-	10	1570	c.1466C>A	c.(1465-1467)tCc>tAc	p.S489Y	FOXN4_ENST00000355216.1_Missense_Mutation_p.S309Y	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	489					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						GTCCGGAGTGGAGTACGCTGT	0.632000													8	8					5.18039e-06	6.09725e-06	0.278610	1	0
KSR1	8844	broad.mit.edu	37	17	25909765	25909765	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:25909765G>T	ENST00000398988.3	+	5	648	c.203G>T	c.(202-204)aGc>aTc	p.S68I	KSR1_ENST00000319524.6_Missense_Mutation_p.S205I|KSR1_ENST00000509603.2_Missense_Mutation_p.S205I|KSR1_ENST00000268763.6_Missense_Mutation_p.S68I	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	203					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TCAGCAGCCAGCCTGCCCTGG	0.672000													40	26					3.66854e-30	7.40794e-30	0.834066	1	0
KIAA2022	340533	broad.mit.edu	37	X	73959997	73959997	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:73959997C>G	ENST00000373468.1	-	3	5046	c.4395G>C	c.(4393-4395)aaG>aaC	p.K1465N	KIAA2022_ENST00000055682.5_Missense_Mutation_p.K1465N			Q5QGS0	K2022_HUMAN	KIAA2022	1465					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GCTCCATGTGCTTTCCCTTAC	0.463000													9	37					0	0	0.307466	0	0
FUT6	2528	broad.mit.edu	37	19	5831888	5831888	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:5831888C>T	ENST00000318336.4	-	3	1885	c.691G>A	c.(691-693)Gga>Aga	p.G231R	FUT6_ENST00000527106.1_Missense_Mutation_p.G231R|FUT6_ENST00000286955.5_Missense_Mutation_p.G231R|FUT6_ENST00000592563.1_Missense_Mutation_p.G231R|FUT6_ENST00000524754.1_Missense_Mutation_p.G231R	NM_000150.2	NP_000141.1	P51993	FUT6_HUMAN	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	231					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)	6						ATCATGGTTCCCTGGGGCAGG	0.612000													48	94					0	0	0.870114	0	0
ATF6	22926	broad.mit.edu	37	1	161823103	161823103	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161823103G>T	ENST00000367942.3	+	12	1590	c.1523G>T	c.(1522-1524)cGt>cTt	p.R508L	ATF6_ENST00000476437.1_3'UTR	NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	508					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			CAGAAAACCCGTATTCTTCAG	0.383000													21	43					2.00529e-23	3.79674e-23	0.654019	1	0
HAPLN1	1404	broad.mit.edu	37	5	82940343	82940343	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:82940343C>A	ENST00000274341.4	-	4	1464	c.614G>T	c.(613-615)tGc>tTc	p.C205F		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	205	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GCCGGCATTGCACCAGTCCAG	0.617000													25	19					6.32553e-13	9.56965e-13	0.681144	1	0
NUP98	4928	broad.mit.edu	37	11	3716722	3716722	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:3716722T>A	ENST00000324932.7	-	26	4544	c.4124A>T	c.(4123-4125)cAg>cTg	p.Q1375L	NUP98_ENST00000488828.1_5'UTR|NUP98_ENST00000359171.4_Missense_Mutation_p.Q1375L|NUP98_ENST00000355260.3_Missense_Mutation_p.Q1375L	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1392					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCTCTCATCCTGGATGAAGGA	0.468000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								107	148					0	0	0.870114	0	0
LATS1	9113	broad.mit.edu	37	6	150001333	150001333	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:150001333C>A	ENST00000543571.1	-	5	2818	c.2271G>T	c.(2269-2271)ctG>ctT	p.L757L	LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Silent_p.L757L	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	757	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CAGCTTCAGCCAGGATATCTC	0.373000													40	29					5.78141e-17	9.69752e-17	0.864702	1	0
OR51A7	119687	broad.mit.edu	37	11	4929011	4929011	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4929011A>T	ENST00000359350.4	+	1	412	c.412A>T	c.(412-414)Agc>Tgc	p.S138C	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TATCCTCACTAGCAACAGGGT	0.378000													20	82					0	0	0.608945	0	0
FAHD2B	151313	broad.mit.edu	37	2	97749915	97749915	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:97749915C>A	ENST00000414820.1	-	7	1055	c.785G>T	c.(784-786)tGg>tTg	p.W262L	FAHD2B_ENST00000440566.2_Missense_Mutation_p.W262L|FAHD2B_ENST00000272610.3_Missense_Mutation_p.W262L			Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing 2B	262							hydrolase activity|metal ion binding			kidney(5)|large_intestine(2)|lung(3)|skin(2)	12						CTGGGAGACCCAGGCTATCAG	0.577000													51	47					5.73376e-24	1.09442e-23	0.870114	1	0
SLC25A3	5250	broad.mit.edu	37	12	98987789	98987789	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:98987789G>T	ENST00000188376.5	+	1	387	c.33G>T	c.(31-33)gcG>gcT	p.A11A	SLC25A3_ENST00000228318.3_Silent_p.A11A|SLC25A3_ENST00000552981.1_Silent_p.A11A|SLC25A3_ENST00000551265.1_Silent_p.A11A|SLC25A3_ENST00000547534.1_Silent_p.A11A|SLC25A3_ENST00000551917.1_Silent_p.A11A|SLC25A3_ENST00000548847.1_Silent_p.A11A|SLC25A3_ENST00000549338.1_Silent_p.A11A|SLC25A3_ENST00000401722.3_Silent_p.A11A	NM_002635.3|NM_213611.2	NP_002626.1|NP_998776.1	Q00325	MPCP_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	11					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(8)|prostate(1)	16		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		TGGCGCGGGCGAACCCCTTCA	0.687000													13	36					3.32936e-07	4.09265e-07	0.539581	1	0
RNF39	80352	broad.mit.edu	37	6	30043110	30043110	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:30043110C>A	ENST00000244360.6	-	1	554	c.457G>T	c.(457-459)Gtg>Ttg	p.V153L	RNF39_ENST00000376751.3_Missense_Mutation_p.V153L	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	153						cytoplasm	zinc ion binding										CTGATTCGCACCTCCACCGCC	0.736000													8	11					0.000442599	0.00048485	0.335167	1	0
SLC28A3	64078	broad.mit.edu	37	9	86914506	86914506	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:86914506T>A	ENST00000376238.4	-	6	708	c.659A>T	c.(658-660)tAc>tTc	p.Y220F	SLC28A3_ENST00000537648.1_Missense_Mutation_p.Y151F	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	220					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						TCTGGTTGGGTACTTGGAAAA	0.393000													17	31					0	0	0.557998	0	0
OR13C4	138804	broad.mit.edu	37	9	107288700	107288700	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:107288700G>A	ENST00000277216.3	-	1	790	c.791C>T	c.(790-792)tCc>tTc	p.S264F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						GAGGTCCTGGGACTTAGGTTT	0.448000													18	52					0	0	0.557998	0	0
IQCF3	401067	broad.mit.edu	37	3	51864437	51864437	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:51864437C>A	ENST00000456080.1	+	8	1250	c.85C>A	c.(85-87)Cat>Aat	p.H29N	IQCF3_ENST00000462079.1_3'UTR|IQCF3_ENST00000446775.1_Missense_Mutation_p.H29N|IQCF3_ENST00000444293.1_Intron|IQCF3_ENST00000440739.2_Missense_Mutation_p.H29N|IQCF3_ENST00000437810.2_Missense_Mutation_p.H29N			P0C7M6	IQCF3_HUMAN	IQ motif containing F3	29										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TGCACAACTGCATCACAGAAA	0.567000													12	31					9.16793e-09	1.20321e-08	0.520397	1	0
FAM115A	9747	broad.mit.edu	37	7	143573529	143573529	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:143573529C>A	ENST00000479870.1	-	2	381	c.173G>T	c.(172-174)cGc>cTc	p.R58L	FAM115A_ENST00000392900.3_Intron|FAM115A_ENST00000355951.2_Missense_Mutation_p.R58L	NM_001206938.1|NM_001206941.1|NM_014719.2	NP_001193867.1|NP_001193870.1|NP_055534.1	Q9Y4C2	F115A_HUMAN	family with sequence similarity 115, member A	58										NS(1)|endometrium(1)|lung(5)	7	Melanoma(164;0.0903)					GACCACCAGGCGGCCACGGCC	0.582000													16	31					2.94398e-08	3.78972e-08	0.557998	1	0
STRN3	29966	broad.mit.edu	37	14	31381014	31381014	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:31381014C>A	ENST00000355683.5	-	10	1530	c.1315G>T	c.(1315-1317)Gta>Tta	p.V439L	STRN3_ENST00000357479.5_Missense_Mutation_p.V523L	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3	469					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ATAGGCTCTACATCTAAAGAG	0.333000													11	33					3.45872e-05	3.94026e-05	0.500413	1	0
DAB2	1601	broad.mit.edu	37	5	39377316	39377316	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:39377316G>A	ENST00000545653.1	-	11	2040	c.1510C>T	c.(1510-1512)Cct>Tct	p.P504S	DAB2_ENST00000509337.1_Missense_Mutation_p.P504S|DAB2_ENST00000339788.6_Missense_Mutation_p.P307S|DAB2_ENST00000320816.6_Missense_Mutation_p.P525S	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	525					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GCCATTGAAGGGGACTGATTG	0.493000													11	35					0	0	0.411799	0	0
ARAP3	64411	broad.mit.edu	37	5	141049520	141049520	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:141049520C>A	ENST00000239440.4	-	15	2283	c.2218G>T	c.(2218-2220)Gtg>Ttg	p.V740L	ARAP3_ENST00000508305.1_Missense_Mutation_p.V642L|ARAP3_ENST00000513878.1_Missense_Mutation_p.V402L	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	740					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GGGGGGCTCACACCCAGACAT	0.562000													40	40					2.40228e-13	3.6937e-13	0.864702	1	0
NOD2	64127	broad.mit.edu	37	16	50744679	50744679	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:50744679G>A	ENST00000300589.2	+	4	962	c.857G>A	c.(856-858)gGc>gAc	p.G286D	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	286					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGCACCCCTGGCCACCTCAAT	0.657000													10	10					0	0	0.435327	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125204374	125204374	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:125204374C>G	ENST00000431078.1	+	6	1142	c.778C>G	c.(778-780)Ctg>Gtg	p.L260V		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	260	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTCTGCCACCCTGGGCAGCCT	0.602000													7	74					0	0	0.278610	0	0
STX1A	6804	broad.mit.edu	37	7	73115084	73115084	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:73115084G>C	ENST00000395156.3	-	9	746	c.719C>G	c.(718-720)tCa>tGa	p.S240*	STX1A_ENST00000484736.1_5'UTR|WBSCR22_ENST00000423166.2_Intron|STX1A_ENST00000395154.3_3'UTR|STX1A_ENST00000222812.3_Silent_p.V255V	NM_001165903.1	NP_001159375.1	Q16623	STX1A_HUMAN	syntaxin 1A (brain)	0	t-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(55;0.0908)|all_lung(88;0.198)				TCTGGTACTTGACGGCCTTCT	0.627000													8	126					0	0	0.361761	0	0
LRRC43	254050	broad.mit.edu	37	12	122684849	122684849	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:122684849G>T	ENST00000339777.4	+	8	1491	c.1463G>T	c.(1462-1464)gGg>gTg	p.G488V	LRRC43_ENST00000425921.1_Missense_Mutation_p.G303V	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	488										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		CTGCTGGCGGGGACCACCGTG	0.637000													32	96					6.05902e-23	1.14031e-22	0.788014	1	0
LILRP2	79166	broad.mit.edu	37	19	55221726	55221726	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55221726G>T	ENST00000413439.1	+	0	1415																											ATGAGGGGTGGGGGTCCCAAG	0.642000													15	5					1.49906e-05	1.72026e-05	0.457914	1	0
ZFP82	284406	broad.mit.edu	37	19	36884543	36884543	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:36884543T>A	ENST00000392161.3	-	5	941	c.699A>T	c.(697-699)gaA>gaT	p.E233D	ZFP82_ENST00000392171.1_Missense_Mutation_p.E233D	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATATGAAAGCTTCCCCACATT	0.428000													67	53					0	0	0.870114	0	0
RPL3L	6123	broad.mit.edu	37	16	1997014	1997014	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:1997014G>T	ENST00000268661.7	-	6	868	c.774C>A	c.(772-774)caC>caA	p.H258Q		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	258					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						CGCGGGCGGGGTGCCAGGCGC	0.672000													30	59					6.53348e-20	1.17105e-19	0.788014	1	0
RYR2	6262	broad.mit.edu	37	1	237670105	237670105	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237670105G>T	ENST00000366574.2	+	23	3026	c.2709G>T	c.(2707-2709)caG>caT	p.Q903H	RYR2_ENST00000542537.1_Missense_Mutation_p.Q887H|RYR2_ENST00000360064.6_Missense_Mutation_p.Q901H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	903	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGGCTGGCAGTATGGTCCGG	0.368000													5	21					0.00198382	0.00212133	0.248553	1	0
SERTAD4	56256	broad.mit.edu	37	1	210411457	210411457	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:210411457G>T	ENST00000367012.3	+	2	382	c.152G>T	c.(151-153)cGg>cTg	p.R51L	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	51							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CAGGGAGACCGGGGAGCTGGT	0.652000													26	65					2.08457e-15	3.3474e-15	0.750413	1	0
F8	2157	broad.mit.edu	37	X	154157597	154157597	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:154157597T>A	ENST00000360256.4	-	14	4668	c.4468A>T	c.(4468-4470)Aca>Tca	p.T1490S		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1490	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCTTGTATGTGACTGAATTT	0.418000													11	59					0	0	0.361761	0	0
AMY2B	280	broad.mit.edu	37	1	104117960	104117960	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:104117960G>T	ENST00000361355.4	+	8	1610	c.994G>T	c.(994-996)Gat>Tat	p.D332Y	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	332					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TACCTTCTGGGATGCTAGGTA	0.373000													40	115					2.26627e-22	4.23548e-22	0.834066	1	0
USH2A	7399	broad.mit.edu	37	1	215847952	215847952	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:215847952G>T	ENST00000366943.2	-	63	13687	c.13301C>A	c.(13300-13302)tCa>tAa	p.S4434*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.S4434*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4434	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGCAGATTTTGACACACTAGC	0.522000										HNSCC(13;0.011)			31	40					4.4194e-11	6.3491e-11	0.769981	1	0
FMO1	2326	broad.mit.edu	37	1	171236682	171236682	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:171236682G>T	ENST00000354841.4	+	2	264	c.132_splice	c.e2-1	p.E45_splice	FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Splice_Site_p.E45_splice|FMO1_ENST00000402921.2_Intron			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	45					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTTGTACAGGAACATGTTGA	0.448000													32	113					1.07637e-12	1.62187e-12	0.804634	1	0
PAXIP1	22976	broad.mit.edu	37	7	154759555	154759555	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:154759555C>G	ENST00000404141.1	-	8	2018	c.1864G>C	c.(1864-1866)Gat>Cat	p.D622H	PAXIP1_ENST00000397192.1_Missense_Mutation_p.D622H|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	622	BRCT 3.|Gln-rich.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		AGTTGCTTATCAGACATCTGC	0.398000													10	34					0	0	0.361761	0	0
SIAH3	283514	broad.mit.edu	37	13	46357687	46357687	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:46357687C>A	ENST00000400405.2	-	2	747	c.641G>T	c.(640-642)tGg>tTg	p.W214L		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	214					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						CGTGGCCTCCCACTTGAGGCG	0.612000													3	14					0.115264	0.117385	0.115264	1	0
ZFP42	132625	broad.mit.edu	37	4	188924698	188924698	+	Missense_Mutation	SNP	G	G	T	rs147517413	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:188924698G>T	ENST00000326866.4	+	4	1145	c.737G>T	c.(736-738)cGg>cTg	p.R246L	ZFP42_ENST00000509524.1_Missense_Mutation_p.R246L	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	246					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AAGCCGTTTCGGTGCACTTTT	0.522000													3	38					0.004672	0.00492037	0.115264	1	0
OR51B4	79339	broad.mit.edu	37	11	5322336	5322336	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:5322336G>T	ENST00000380224.1	-	1	890	c.841C>A	c.(841-843)Cct>Act	p.P281T	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACGAATGGAGGAAAGAGAAAA	0.428000													20	42					5.35356e-11	7.65026e-11	0.639603	1	0
CDH18	1016	broad.mit.edu	37	5	19591217	19591217	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:19591217G>T	ENST00000507958.1	-	9	1938	c.948C>A	c.(946-948)ttC>ttA	p.F316L	CDH18_ENST00000502796.1_Missense_Mutation_p.F316L|CDH18_ENST00000511273.1_Missense_Mutation_p.F316L|CDH18_ENST00000274170.4_Missense_Mutation_p.F316L|CDH18_ENST00000506372.1_Missense_Mutation_p.F316L|CDH18_ENST00000382275.1_Missense_Mutation_p.F316L			Q13634	CAD18_HUMAN	cadherin 18, type 2	316	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGGAGATTGAGAATATTCCCA	0.403000													13	80					2.61681e-11	3.78252e-11	0.457914	1	0
VCP	7415	broad.mit.edu	37	9	35060352	35060352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:35060352C>T	ENST00000358901.6	-	13	2548	c.1653G>A	c.(1651-1653)tgG>tgA	p.W551*		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	551					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACTCCCCAAACCACATGGTGA	0.488000													34	60					0	0	0.819951	0	0
STYK1	55359	broad.mit.edu	37	12	10772780	10772780	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:10772780C>T	ENST00000075503.3	-	11	1752	c.1232G>A	c.(1231-1233)aGa>aAa	p.R411K		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	411						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity	p.R411T(1)		breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						GCTCTCCACTCTGATGCCGGC	0.458000										HNSCC(73;0.22)			28	111					0	0	0.740014	0	0
RBM34	23029	broad.mit.edu	37	1	235299086	235299086	+	Splice_Site	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:235299086C>T	ENST00000408888.3	-	10	1120		c.e10-1		RBM34_ENST00000495224.1_Splice_Site|RBM34_ENST00000366606.3_Splice_Site			P42696	RBM34_HUMAN	RNA binding motif protein 34							nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TCTTCAACTTCTGAAAACAAA	0.413000													12	59					0	0	0.457914	0	0
FAM71C	196472	broad.mit.edu	37	12	100042192	100042192	+	Silent	SNP	C	C	A	rs147841911	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:100042192C>A	ENST00000324341.1	+	1	662	c.240C>A	c.(238-240)ctC>ctA	p.L80L	ANKS1B_ENST00000329257.7_Intron|ANKS1B_ENST00000547776.2_Intron|ANKS1B_ENST00000547010.1_Intron	NM_153364.3	NP_699195.1	Q8NEG0	FA71C_HUMAN	family with sequence similarity 71, member C	80										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		GCCCCTGCCTCACACTACCTG	0.552000													16	88					4.7546e-09	6.31933e-09	0.500413	1	0
SVOP	55530	broad.mit.edu	37	12	109311863	109311863	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:109311863A>G	ENST00000299134.5	-	12	1109	c.1110T>C	c.(1108-1110)cgT>cgC	p.R370R		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						CCAGAAATAAACGCTCTTGCA	0.498000													6	7					0	0	0.248553	0	0
MDGA2	161357	broad.mit.edu	37	14	47314974	47314974	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:47314974G>T	ENST00000426342.1	-	16	2836	c.2090C>A	c.(2089-2091)aCt>aAt	p.T697N	MDGA2_ENST00000357362.3_Missense_Mutation_p.T697N|MDGA2_ENST00000399222.3_Missense_Mutation_p.T128N|MDGA2_ENST00000439988.2_Missense_Mutation_p.T926N|MDGA2_ENST00000399232.2_Missense_Mutation_p.T995N	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	926					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CTTACTCTTAGTTGCTAGGTC	0.313000													18	37					7.45023e-12	1.09971e-11	0.592651	1	0
MAP2	4133	broad.mit.edu	37	2	210574658	210574658	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:210574658G>A	ENST00000360351.4	+	12	5259	c.4753G>A	c.(4753-4755)Gca>Aca	p.A1585T	MAP2_ENST00000392194.1_Missense_Mutation_p.A229T|MAP2_ENST00000199940.6_Missense_Mutation_p.A286T|MAP2_ENST00000447185.1_Missense_Mutation_p.A1581T|MAP2_ENST00000361559.4_Missense_Mutation_p.A229T|MAP2_ENST00000475600.1_3'UTR	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1585					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATTCGCAGAGCAGGGAAGAG	0.507000													19	35					0	0	0.592651	0	0
IMPG1	3617	broad.mit.edu	37	6	76744391	76744391	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:76744391C>G	ENST00000369963.3	-	2	370	c.181G>C	c.(181-183)Gac>Cac	p.D61H	IMPG1_ENST00000369950.3_Missense_Mutation_p.D139H			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	139					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTTCCAATGTCAAAGAGGCAG	0.493000													6	172					0	0	0.217242	0	0
ALS2	57679	broad.mit.edu	37	2	202598062	202598062	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:202598062C>A	ENST00000264276.6	-	13	2889	c.2517G>T	c.(2515-2517)ttG>ttT	p.L839F	ALS2_ENST00000457679.2_Missense_Mutation_p.L151F	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	839	DH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						GTCTGATTGGCAAGAAAAACA	0.358000													16	24					1.5739e-10	2.22045e-10	0.500413	1	0
MON2	23041	broad.mit.edu	37	12	62894640	62894640	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:62894640G>C	ENST00000393630.3	+	6	1034	c.643G>C	c.(643-645)Gat>Cat	p.D215H	MON2_ENST00000393632.2_Missense_Mutation_p.D215H|MON2_ENST00000546600.1_Missense_Mutation_p.D215H|MON2_ENST00000552115.1_Missense_Mutation_p.D215H|MON2_ENST00000549378.1_3'UTR|MON2_ENST00000393629.2_Missense_Mutation_p.D215H|MON2_ENST00000280379.6_Missense_Mutation_p.D215H|MON2_ENST00000552738.1_Missense_Mutation_p.D215H	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	215					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTGTGCTAAAGATGCATATAT	0.308000													30	69					0	0	0.796494	0	0
IL7R	3575	broad.mit.edu	37	5	35873732	35873732	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:35873732G>T	ENST00000303115.3	+	5	817	c.688G>T	c.(688-690)Gag>Tag	p.E230*	IL7R_ENST00000343305.4_Nonsense_Mutation_p.E230*|IL7R_ENST00000506850.1_Nonsense_Mutation_p.E230*	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	230					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CAGAACTCCAGAGATCAATAA	0.423000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						4	78					2.0095e-06	2.40577e-06	0.248553	1	0
NALCN	259232	broad.mit.edu	37	13	101717840	101717840	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:101717840T>A	ENST00000251127.6	-	40	4601	c.4520A>T	c.(4519-4521)aAg>aTg	p.K1507M		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1507						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAGCTTGTCCTTGTCCAGGTC	0.582000													215	57					0	0	0.870114	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168389	142168389	+	RNA	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142168389T>C	ENST00000454561.2	-	0	534																											GCCAAGCTGCTGGCACAGAGA	0.532000													13	93					0	0	0.557998	0	0
DGKG	1608	broad.mit.edu	37	3	186015983	186015983	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:186015983C>G	ENST00000265022.3	-	4	719	c.180G>C	c.(178-180)agG>agC	p.R60S	DGKG_ENST00000344484.4_Missense_Mutation_p.R60S|DGKG_ENST00000382164.4_Missense_Mutation_p.R60S|DGKG_ENST00000544847.1_Missense_Mutation_p.R60S	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	60					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAGGTACGCCCTCATGAACA	0.567000													25	67					0	0	0.667858	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921530	12921530	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:12921530C>T	ENST00000240189.2	+	4	1408	c.1321C>T	c.(1321-1323)Ctg>Ttg	p.L441L		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	441										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATGTGTACACTGAGGGAATT	0.552000													66	134					0	0	0.870114	0	0
BBX	56987	broad.mit.edu	37	3	107435487	107435487	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:107435487G>T	ENST00000415149.2	+	5	523	c.196G>T	c.(196-198)Gat>Tat	p.D66Y	BBX_ENST00000416476.2_Missense_Mutation_p.D66Y|BBX_ENST00000402543.1_Missense_Mutation_p.D66Y|BBX_ENST00000406780.1_Missense_Mutation_p.D66Y|BBX_ENST00000325805.8_Missense_Mutation_p.D66Y	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	66					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			CCTAGAGCAAGATGTTGGTGA	0.413000													22	98					4.72057e-08	6.02722e-08	0.667858	1	0
ABHD3	171586	broad.mit.edu	37	18	19239230	19239230	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:19239230C>T	ENST00000578270.1	-	5	1098	c.158G>A	c.(157-159)gGt>gAt	p.G53D	ABHD3_ENST00000289119.2_Missense_Mutation_p.G248D|ABHD3_ENST00000580981.1_Missense_Mutation_p.G195D			Q8WU67	ABHD3_HUMAN	abhydrolase domain containing 3	248						integral to membrane	carboxylesterase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|prostate(2)	10						GGTGTTCCAACCAACGGAAAA	0.413000													12	153					0	0	0.411799	0	0
ZNF556	80032	broad.mit.edu	37	19	2878099	2878099	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:2878099G>T	ENST00000586426.1	+	4	1227	c.1140G>T	c.(1138-1140)tgG>tgT	p.W380C	ZNF556_ENST00000307635.2_Missense_Mutation_p.W381C			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTATGGTTGGTCCTCATCTT	0.473000													9	26					2.17888e-05	2.49279e-05	0.335167	1	0
WHSC1L1	54904	broad.mit.edu	37	8	38172976	38172976	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:38172976C>T	ENST00000317025.8	-	11	2590	c.2073G>A	c.(2071-2073)tcG>tcA	p.S691S	WHSC1L1_ENST00000433384.2_Silent_p.S691S|WHSC1L1_ENST00000527502.1_Silent_p.S691S	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	691					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TGCCTCTTCTCGACAAACTTG	0.428000			T	NUP98	AML								20	145					0	0	0.608945	0	0
CNBD1	168975	broad.mit.edu	37	8	88249151	88249151	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:88249151T>A	ENST00000518476.1	+	6	633	c.582T>A	c.(580-582)gtT>gtA	p.V194V	CNBD1_ENST00000522427.1_3'UTR	NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	194										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TTTCAGTGGTTGCAAATGATG	0.348000													17	67					0	0	0.575678	0	0
NCOA2	10499	broad.mit.edu	37	8	71044133	71044133	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:71044133C>G	ENST00000452400.2	-	16	3444	c.3263G>C	c.(3262-3264)cGg>cCg	p.R1088P	NCOA2_ENST00000267974.4_Missense_Mutation_p.R176P	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1088					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			ATCAAAATTCCGCAAGGCCAG	0.562000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								7	25					0	0	0.278610	0	0
SSPO	23145	broad.mit.edu	37	7	149518044	149518044	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:149518044G>A	ENST00000378016.2	+	0	12387							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGGGCCCCGGGGAGCCAGC	0.682000													10	14					0	0	0.387290	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940320	67940320	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:67940320C>A	ENST00000357461.2	-	3	730	c.321G>T	c.(319-321)caG>caT	p.Q107H	TMEM229B_ENST00000557006.1_Missense_Mutation_p.Q107H	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	107						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CAAAGTCGAACTGGGAGTAGT	0.607000													4	7					0.00024832	0.000273297	0.150653	1	0
POM121C	100101267	broad.mit.edu	37	7	75070254	75070254	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:75070254C>G	ENST00000453279.2	-	5	1069	c.205G>C	c.(205-207)Gat>Cat	p.D69H	POM121C_ENST00000257665.5_Missense_Mutation_p.D311H	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	311	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						TCCTGGCCATCAAGGAATATT	0.463000													21	289					0	0	0.769981	0	0
TUBB4B	10383	broad.mit.edu	37	9	140137871	140137871	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:140137871G>C	ENST00000340384.4	+	4	1349	c.1201G>C	c.(1201-1203)Gag>Cag	p.E401Q		NM_006088.5	NP_006079.1	P68371	TBB2C_HUMAN	tubulin, beta 4B class IVb	401					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding										GTACACGGGCGAGGGCATGGA	0.612000													129	227					0	0	0.870114	0	0
KBTBD4	55709	broad.mit.edu	37	11	47599534	47599534	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:47599534C>A	ENST00000533290.1	-	1	807	c.93G>T	c.(91-93)gaG>gaT	p.E31D	NDUFS3_ENST00000533507.1_Intron|KBTBD4_ENST00000430070.2_Missense_Mutation_p.E22D|KBTBD4_ENST00000395288.2_Missense_Mutation_p.E6D|KBTBD4_ENST00000526005.1_Missense_Mutation_p.E6D|KBTBD4_ENST00000450908.1_3'UTR|KBTBD4_ENST00000525720.1_Missense_Mutation_p.E55D			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	6										NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						ATGCTCCAGGCTCCTCTGGTG	0.483000													20	36					3.28513e-13	5.00616e-13	0.667858	1	0
NOSIP	51070	broad.mit.edu	37	19	50059812	50059812	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:50059812C>G	ENST00000391853.3	-	8	870	c.719G>C	c.(718-720)cGg>cCg	p.R240P	NOSIP_ENST00000596358.1_Missense_Mutation_p.R240P|NOSIP_ENST00000339093.3_Missense_Mutation_p.R243P	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	240					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		TCACGAGGGCCGCAGCACAGC	0.706000													8	49					0	0	0.361761	0	0
GAS1	2619	broad.mit.edu	37	9	89561087	89561087	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:89561087C>A	ENST00000298743.7	-	1	1017	c.608G>T	c.(607-609)tGc>tTc	p.C203F		NM_002048.2	NP_002039.2	P54826	GAS1_HUMAN	growth arrest-specific 1	203					cell cycle arrest|negative regulation of S phase of mitotic cell cycle	anchored to plasma membrane				kidney(1)|lung(2)|skin(1)	4						GACGGTGCGGCATTCGTCCGT	0.672000													16	15					9.7654e-05	0.000108942	0.557998	1	0
MIR518A1	574488	broad.mit.edu	37	19	54234279	54234279	+	RNA	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:54234279A>T	ENST00000385068.1	+	0	20					NR_030210.1																						GTGACTGCAAAGGGAAGCCCT	0.433000													73	39					0	0	0.870114	0	0
KIF26A	26153	broad.mit.edu	37	14	104624222	104624222	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:104624222C>A	ENST00000315264.7	+	3	827	c.449C>A	c.(448-450)aCc>aAc	p.T150N	KIF26A_ENST00000423312.2_Missense_Mutation_p.T289N			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	289					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GTCACCCCCACCCCGGGCTCG	0.697000													15	23					2.48551e-13	3.80612e-13	0.520397	1	0
MYO9A	4649	broad.mit.edu	37	15	72227692	72227692	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:72227692C>A	ENST00000356056.5	-	17	2984	c.2512G>T	c.(2512-2514)Gga>Tga	p.G838*	MYO9A_ENST00000424560.1_Nonsense_Mutation_p.G838*|MYO9A_ENST00000566885.1_Nonsense_Mutation_p.G458*|MYO9A_ENST00000444904.1_Nonsense_Mutation_p.G819*|MYO9A_ENST00000564571.1_Nonsense_Mutation_p.G838*|MYO9A_ENST00000563542.1_5'UTR	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	838					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GTGAGAATTCCATGGGCTCTC	0.373000													27	58					1.55811e-20	2.82229e-20	0.729181	1	0
CHM	1121	broad.mit.edu	37	X	85119744	85119744	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:85119744C>A	ENST00000357749.2	-	15	1882	c.1853G>T	c.(1852-1854)gGa>gTa	p.G618V	CHM_ENST00000467744.1_Intron|CHM_ENST00000537751.1_Missense_Mutation_p.G470V	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	618					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TAAACTGTCTCCATCAAGGAT	0.478000													8	6					5.18039e-06	6.09725e-06	0.278610	1	0
TFDP1	7027	broad.mit.edu	37	13	114286059	114286059	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:114286059G>T	ENST00000375370.5	+	5	520	c.308_splice	c.e5+1	p.G103_splice	TFDP1_ENST00000465174.1_3'UTR|TFDP1_ENST00000538138.1_Intron|TFDP1_ENST00000544902.1_Intron	NM_007111.4	NP_009042.1	Q14186	TFDP1_HUMAN	transcription factor Dp-1	103					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			TGGTCTGCCGGGTGAGCACTT	0.612000										TSP Lung(29;0.18)			10	30					6.40141e-05	7.20973e-05	0.387290	1	0
PCDHA10	56139	broad.mit.edu	37	5	140235843	140235843	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140235843C>T	ENST00000307360.5	+	1	210	c.210C>T	c.(208-210)caC>caT	p.H70H	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000506939.2_Silent_p.H70H|PCDHA1_ENST00000504120.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAAAGACACGGGGACCTTC	0.627000													34	320					0	0	0.853193	0	0
IQCF2	389123	broad.mit.edu	37	3	51897349	51897349	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:51897349C>T	ENST00000333127.3	+	3	487	c.458C>T	c.(457-459)aCt>aTt	p.T153I	IQCF2_ENST00000429548.1_3'UTR	NM_203424.1	NP_982248.1	Q8IXL9	IQCF2_HUMAN	IQ motif containing F2	153										endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GTCACAGCCACTCACCTGCAG	0.547000													48	118					0	0	0.870114	0	0
LCMT2	9836	broad.mit.edu	37	15	43622382	43622382	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:43622382C>A	ENST00000305641.5	-	1	421	c.306G>T	c.(304-306)gcG>gcT	p.A102A	LCMT2_ENST00000544735.1_Intron|LCMT2_ENST00000567039.1_Intron	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	102					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCAGGCGGCCCGCGGTTTTTA	0.622000													6	23					0.000157383	0.000174438	0.278610	1	0
ZNF461	92283	broad.mit.edu	37	19	37147376	37147376	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:37147376C>A	ENST00000588268.1	-	4	433	c.206G>T	c.(205-207)aGg>aTg	p.R69M	ZNF461_ENST00000360357.4_Missense_Mutation_p.R69M	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TGTCTCTTCCCTCACAACCAT	0.488000													21	18					3.1745e-13	4.84542e-13	0.729181	1	0
COL9A1	1297	broad.mit.edu	37	6	70991092	70991092	+	Splice_Site	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:70991092C>T	ENST00000357250.6	-	8	1035		c.e8+1		COL9A1_ENST00000320755.7_Splice_Site|COL9A1_ENST00000370496.3_Splice_Site|COL9A1_ENST00000370499.4_Splice_Site	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1						axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TAGAAACTTACGTCGATGCCA	0.562000													16	26					0	0	0.608945	0	0
NLRC5	84166	broad.mit.edu	37	16	57062297	57062297	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:57062297G>T	ENST00000436936.1	+	8	2468	c.2243_splice	c.e8+1	p.S748_splice	NLRC5_ENST00000262510.6_Splice_Site_p.S748_splice|NLRC5_ENST00000539144.1_Splice_Site_p.S748_splice|NLRC5_ENST00000308149.7_Splice_Site_p.S748_splice			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	748					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AAAGAAGTCAGGTGAGTGATC	0.557000													24	18					8.24728e-16	1.34501e-15	0.681144	1	0
LAYN	143903	broad.mit.edu	37	11	111420472	111420472	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:111420472G>T	ENST00000375614.2	+	3	849	c.513G>T	c.(511-513)aaG>aaT	p.K171N	LAYN_ENST00000525126.1_Missense_Mutation_p.K179N|LAYN_ENST00000533265.1_Missense_Mutation_p.K171N|LAYN_ENST00000375615.3_Missense_Mutation_p.K179N|LAYN_ENST00000436913.2_Intron|LAYN_ENST00000528924.1_Intron	NM_178834.4	NP_849156.1	Q6UX15	LAYN_HUMAN	layilin	179	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		GCAACATGAAGAACAATTTCA	0.498000													14	104					2.48551e-13	3.80612e-13	0.520397	1	0
HSD3B2	3284	broad.mit.edu	37	1	119962117	119962117	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:119962117G>T	ENST00000543831.1	+	3	468	c.219G>T	c.(217-219)caG>caT	p.Q73H	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Missense_Mutation_p.Q73H	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	73					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GAGCCTGCCAGGACGTCTCGG	0.493000													20	41					1.96292e-10	2.74459e-10	0.592651	1	0
PCK1	5105	broad.mit.edu	37	20	56140139	56140139	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:56140139C>A	ENST00000319441.4	+	9	1526	c.1362C>A	c.(1360-1362)gtC>gtA	p.V454V	PCK1_ENST00000543666.1_Silent_p.V137V|PCK1_ENST00000535860.1_3'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	454					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AACATGGAGTCTTTGTGGGGG	0.463000													55	87					1.77791e-30	3.60176e-30	0.870114	1	0
SPTA1	6708	broad.mit.edu	37	1	158648220	158648220	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158648220G>T	ENST00000368148.3	-	6	963	c.783C>A	c.(781-783)tcC>tcA	p.S261S	SPTA1_ENST00000368147.3_Silent_p.S261S	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	261			S -> P (in EL2).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTGCAGCATTGGACAGAGCTT	0.438000													26	282					4.74835e-14	7.4161e-14	0.750413	1	0
KMT2D	8085	broad.mit.edu	37	12	49445140	49445140	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:49445140C>A	ENST00000301067.7	-	10	2325	c.2326G>T	c.(2326-2328)Gag>Tag	p.E776*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGCATGGCTCCTCAGGCTGG	0.672000													9	17					6.53275e-17	1.09286e-16	0.457914	1	0
SPTA1	6708	broad.mit.edu	37	1	158626361	158626361	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158626361G>T	ENST00000368148.3	-	20	3071	c.2891C>A	c.(2890-2892)gCc>gAc	p.A964D	SPTA1_ENST00000368147.3_Missense_Mutation_p.A964D	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	964					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TACCTGGCAGGCGTTTGCCTG	0.403000													306	112					4.33064e-187	9.97585e-187	0.870114	1	0
TCL1B	9623	broad.mit.edu	37	14	96157121	96157121	+	Missense_Mutation	SNP	C	C	T	rs28625553		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:96157121C>T	ENST00000340722.7	+	2	262	c.211C>T	c.(211-213)Cgg>Tgg	p.R71W	RP11-1070N10.6_ENST00000461160.1_RNA	NM_004918.3	NP_004909.1	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	71										cervix(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AGTGCATACCCGGGAGCTACT	0.592000													45	152					0	0	0.864702	0	0
ISOC1	51015	broad.mit.edu	37	5	128442668	128442668	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:128442668G>T	ENST00000173527.5	+	4	679	c.663G>T	c.(661-663)ctG>ctT	p.L221L		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	221						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		AAACTGCCCTGGAGCTAGTTG	0.423000													16	10					3.32936e-07	4.09265e-07	0.539581	1	0
CHCHD3	54927	broad.mit.edu	37	7	132481247	132481247	+	Missense_Mutation	SNP	C	C	A	rs147544227	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:132481247C>A	ENST00000262570.5	-	7	760	c.616G>T	c.(616-618)Gct>Tct	p.A206S	CHCHD3_ENST00000476546.1_5'UTR|CHCHD3_ENST00000448878.1_Missense_Mutation_p.A211S	NM_017812.2	NP_060282.1	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 3	206	CHCH.				inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	7						GTGGCCAGAGCGGAGCATTTG	0.522000													45	37					6.68952e-21	1.21993e-20	0.864702	1	0
SEC16B	89866	broad.mit.edu	37	1	177934212	177934212	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:177934212G>C	ENST00000308284.6	-	4	592	c.503C>G	c.(502-504)cCa>cGa	p.P168R	RP4-798P15.3_ENST00000528461.1_Missense_Mutation_p.P168R|RP4-798P15.3_ENST00000354921.2_5'UTR|SEC16B_ENST00000464631.1_Missense_Mutation_p.P168R	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	168	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						TGTTCCAAATGGACTGTGCTG	0.453000													5	35					0	0	0.248553	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616031	140616031	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140616031G>T	ENST00000526308.1	+	0	2094					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						AGCGCGACGCGGCCAAGCACA	0.701000													33	18					3.78316e-11	5.43919e-11	0.819951	1	0
PITPNB	23760	broad.mit.edu	37	22	28315111	28315111	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:28315111C>G	ENST00000455418.3	-	1	4	c.5G>C	c.(4-6)gGa>gCa	p.G2A	PITPNB_ENST00000320996.10_Intron|PITPNB_ENST00000335272.5_Intron			P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	0					lipid metabolic process|transport	Golgi apparatus	lipid binding			large_intestine(4)|lung(3)|skin(1)	8						CAACAAATCTCCCATCACTGC	0.627000													24	104					0	0	0.693898	0	0
USP17L2	377630	broad.mit.edu	37	8	11995977	11995977	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:11995977A>T	ENST00000333796.3	-	1	609	c.293T>A	c.(292-294)cTg>cAg	p.L98Q	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	98					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						TGTGTATGTCAGGCACTGCAG	0.562000													42	107					0	0	0.870114	0	0
ANGPT4	51378	broad.mit.edu	37	20	896565	896565	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:896565G>C	ENST00000381922.3	-	1	395	c.293C>G	c.(292-294)aCg>aGg	p.T98R	ANGPT4_ENST00000546022.1_Missense_Mutation_p.T98R	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	98					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						CAGCCACTGCGTGTTGTTCTG	0.597000													95	117					0	0	0.870114	0	0
ACACB	32	broad.mit.edu	37	12	109577604	109577604	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:109577604G>T	ENST00000338432.7	+	2	513	c.394G>T	c.(394-396)Ggc>Tgc	p.G132C	ACACB_ENST00000377854.5_Missense_Mutation_p.G132C|ACACB_ENST00000377848.3_Missense_Mutation_p.G132C			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	132					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGATACCAATGGCCTGTCCTC	0.592000													63	113					5.44642e-36	1.14655e-35	0.870114	1	0
AADACL2	344752	broad.mit.edu	37	3	151474901	151474901	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:151474901C>A	ENST00000356517.3	+	5	834	c.725C>A	c.(724-726)aCc>aAc	p.T242N	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	242						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			ATAGTTTTGACCAGGGATGTA	0.408000													68	237					9.72016e-57	2.17261e-56	0.870114	1	0
SLC35F4	341880	broad.mit.edu	37	14	58038628	58038628	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:58038628G>T	ENST00000556826.1	-	5	1153	c.917C>A	c.(916-918)aCa>aAa	p.T306K	SLC35F4_ENST00000339762.6_Missense_Mutation_p.T342K|SLC35F4_ENST00000554729.1_Missense_Mutation_p.T183K	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TAATGCAGATGTAGAGGCTGA	0.398000													5	16					0.184627	0.18651	0.184627	1	0
KDM5C	8242	broad.mit.edu	37	X	53228302	53228302	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:53228302G>T	ENST00000452825.3	-	13	2431	c.1899C>A	c.(1897-1899)ctC>ctA	p.L633L	KDM5C_ENST00000375383.3_Silent_p.L659L|KDM5C_ENST00000375401.3_Silent_p.L700L|KDM5C_ENST00000404049.3_Silent_p.L699L|KDM5C_ENST00000375379.3_Silent_p.L700L	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	700	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CATCATCTGGGAGCAGCTCGA	0.522000			"""N, F, S"""		clear cell renal carcinoma								28	36					4.11147e-35	8.59753e-35	0.788014	1	0
SLC12A5	57468	broad.mit.edu	37	20	44670121	44670121	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:44670121C>A	ENST00000454036.1	+	8	1153	c.1077C>A	c.(1075-1077)acC>acA	p.T359T	SLC12A5_ENST00000243964.3_Silent_p.T336T|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	359					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AATACTTCACCCGAAACAATG	0.577000													12	86					2.32078e-09	3.13323e-09	0.479597	1	0
NPY2R	4887	broad.mit.edu	37	4	156135578	156135578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:156135578C>T	ENST00000329476.3	+	2	976	c.487C>T	c.(487-489)Cga>Tga	p.R163*	NPY2R_ENST00000506608.1_Nonsense_Mutation_p.R163*	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	163					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				GATCTCCAAGCGAATCAGCTT	0.552000													7	32					0	0	0.278610	0	0
CA3	761	broad.mit.edu	37	8	86357418	86357418	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:86357418C>A	ENST00000285381.2	+	5	561	c.478C>A	c.(478-480)Ctt>Att	p.L160I	RP11-317J10.2_ENST00000517697.1_RNA|RP11-317J10.2_ENST00000521761.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	160					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCAGATTTTCCTTGATGCATT	0.328000													15	47					9.7654e-05	0.000108942	0.557998	1	0
HDAC9	9734	broad.mit.edu	37	7	19035668	19035668	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19035668G>T	ENST00000406451.3	+	26	3334	c.3184G>T	c.(3184-3186)Gag>Tag	p.E1062*	HDAC9_ENST00000401921.1_Nonsense_Mutation_p.E1021*|HDAC9_ENST00000441542.2_Nonsense_Mutation_p.E1065*	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	0					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GCCTATGGAAGAGGAGCCAGC	0.453000													9	20					3.07112e-06	3.6397e-06	0.387290	1	0
MYH1	4619	broad.mit.edu	37	17	10418197	10418197	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:10418197G>T	ENST00000226207.5	-	6	615	c.521C>A	c.(520-522)tCt>tAt	p.S174Y	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	174	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GATCAAGATAGACTGATTCTC	0.318000													45	76					1.13205e-32	2.33097e-32	0.870114	1	0
C2CD3	26005	broad.mit.edu	37	11	73809197	73809197	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:73809197T>A	ENST00000334126.7	-	16	3062	c.2836A>T	c.(2836-2838)Agt>Tgt	p.S946C	C2CD3_ENST00000313663.7_Missense_Mutation_p.S946C			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	946						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					ACTCGAAGACTCCCATTTTGG	0.463000													17	54					0	0	0.592651	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803857	23803857	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:23803857G>T	ENST00000264867.2	-	11	2250	c.2131C>A	c.(2131-2133)Cgg>Agg	p.R711R	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	711	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				CCATCATCCCGCAGATTTACT	0.403000													14	78					4.7546e-09	6.31933e-09	0.500413	1	0
TEDDM1	127670	broad.mit.edu	37	1	182369333	182369333	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:182369333A>T	ENST00000367565.1	-	1	418	c.288T>A	c.(286-288)tgT>tgA	p.C96*		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	96						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						CTAGGCCCACACACCTCTGAG	0.507000													46	165					0	0	0.870114	0	0
BPIFB4	149954	broad.mit.edu	37	20	31672752	31672752	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:31672752C>T	ENST00000375483.3	+	4	732	c.732C>T	c.(730-732)ggC>ggT	p.G244G		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	244						cytoplasm|extracellular region	lipid binding										TCCTGCCCGGCGTGGGTGTCT	0.667000													19	45					0	0	0.681144	0	0
DNAH11	8701	broad.mit.edu	37	7	21789863	21789863	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:21789863G>T	ENST00000328843.6	+	55	8873	c.8842G>T	c.(8842-8844)Gat>Tat	p.D2948Y	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2941Y			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2948	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCTGTTCAGCGATGAAGATGT	0.358000									Kartagener syndrome				15	30					3.41278e-10	4.73662e-10	0.520397	1	0
SPTA1	6708	broad.mit.edu	37	1	158627270	158627270	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158627270A>T	ENST00000368148.3	-	19	2982	c.2802T>A	c.(2800-2802)gcT>gcA	p.A934A	SPTA1_ENST00000368147.3_Silent_p.A934A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	934					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ACCTTACCCCAGCTGCTTCTT	0.443000													17	328					0	0	0.592651	0	0
SMPD1	6609	broad.mit.edu	37	11	6415525	6415525	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:6415525A>T	ENST00000342245.4	+	6	1752	c.1584A>T	c.(1582-1584)atA>atT	p.I528I	SMPD1_ENST00000356761.2_Silent_p.I472I|SMPD1_ENST00000299397.3_Silent_p.I484I|SMPD1_ENST00000527275.1_Silent_p.I527I	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	526					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	AGGCAAACATACCGGGAGCCA	0.552000													14	38					0	0	0.557998	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17401513	17401513	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:17401513C>G	ENST00000377602.4	-	4	451	c.377_splice	c.e4+1	p.R126_splice		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	126					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						AAAAAATTACCTAAAATTTGC	0.284000													14	13					0	0	0.520397	0	0
TBPL2	387332	broad.mit.edu	37	14	55881151	55881151	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:55881151G>T	ENST00000247219.5	-	7	1144	c.1074C>A	c.(1072-1074)atC>atA	p.I358I		NM_199047.2	NP_950248.1	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	358					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8						ATGCTTCATAGATCTCAGAAC	0.279000													5	41					1.024e-07	1.29427e-07	0.184627	1	0
HIST1H4G	8369	broad.mit.edu	37	6	26246947	26246947	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:26246947C>A	ENST00000244537.4	-	1	312	c.259G>T	c.(259-261)Gtg>Ttg	p.V87L		NM_003547.2	NP_003538.1	Q99525	H4G_HUMAN	histone cluster 1, H4g	87					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				ACGTAGACCACGGCCATGGCG	0.572000													15	53					9.16793e-09	1.20321e-08	0.520397	1	0
HEPACAM	220296	broad.mit.edu	37	11	124794810	124794810	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:124794810G>C	ENST00000298251.4	-	2	646	c.241C>G	c.(241-243)Cag>Gag	p.Q81E		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	81	Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CCAATGGACTGCACCACGGTC	0.587000													30	78					0	0	0.788014	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113176674	113176674	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:113176674C>G	ENST00000261965.3	-	14	1891	c.1705G>C	c.(1705-1707)Ggt>Cgt	p.G569R	TUBGCP3_ENST00000462580.1_5'UTR|TUBGCP3_ENST00000375669.3_Missense_Mutation_p.G569R	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	569					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					TCTCCTTGACCAAGAAGCAGG	0.378000													9	599					0	0	0.361761	0	0
TRAV5	28688	broad.mit.edu	37	14	22217831	22217831	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:22217831G>A	ENST00000390427.3	+	0	194																											CAAGAACCTGGAGCAGGTCTC	0.413000													19	16					0	0	0.608945	0	0
OR52E4	390081	broad.mit.edu	37	11	5905928	5905928	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:5905928A>G	ENST00000316987.2	+	1	428	c.406A>G	c.(406-408)Atg>Gtg	p.M136V		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGTACACCATGATCCTCAC	0.438000													11	69					0	0	0.457914	0	0
CADM3	57863	broad.mit.edu	37	1	159166200	159166200	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:159166200G>A	ENST00000368125.4	+	6	895	c.738G>A	c.(736-738)gaG>gaA	p.E246E	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Silent_p.E280E	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	246	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					ATCCTCGTGAGGGCCAGAAGC	0.512000											OREG0013913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	51					0	0	0.693898	0	0
SRPK3	26576	broad.mit.edu	37	X	153046802	153046802	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153046802G>T	ENST00000489426.1	+	8	2757		c.e8+1		SRPK3_ENST00000370101.3_Splice_Site|SRPK3_ENST00000393786.3_Splice_Site|SRPK3_ENST00000370104.1_Splice_Site|SRPK3_ENST00000370108.3_Splice_Site|SRPK3_ENST00000370100.1_Splice_Site			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3						cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TACTGCAAGGGTGAGACTTGG	0.647000													17	35					7.41877e-09	9.78515e-09	0.608945	1	0
PREX2	80243	broad.mit.edu	37	8	69012023	69012023	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:69012023C>G	ENST00000288368.4	+	23	2937	c.2660C>G	c.(2659-2661)gCc>gGc	p.A887G	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	887					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAATTCAGTGCCCTTTGCAGT	0.338000													24	98					0	0	0.717897	0	0
KEL	3792	broad.mit.edu	37	7	142639554	142639554	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142639554G>T	ENST00000355265.2	-	18	2478	c.2004C>A	c.(2002-2004)agC>agA	p.S668R		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	668					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCTGCTGGGGGCTGAGGTCCA	0.577000													4	18					0.000602214	0.000654747	0.184627	1	0
CTNNB1	1499	broad.mit.edu	37	3	41268746	41268746	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:41268746G>T	ENST00000349496.5	+	7	1264	c.984G>T	c.(982-984)atG>atT	p.M328I	CTNNB1_ENST00000396185.3_Missense_Mutation_p.M328I|CTNNB1_ENST00000405570.1_Missense_Mutation_p.M328I|CTNNB1_ENST00000453024.1_Missense_Mutation_p.M321I|CTNNB1_ENST00000396183.3_Missense_Mutation_p.M328I	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	328					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TAAATATAATGAGGACCTATA	0.398000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				12	36					7.03913e-09	9.3162e-09	0.411799	1	0
FMR1	2332	broad.mit.edu	37	X	147019024	147019024	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:147019024A>G	ENST00000218200.8	+	11	1259	c.1030A>G	c.(1030-1032)Agg>Ggg	p.R344G	FMR1_ENST00000439526.2_Missense_Mutation_p.R342G|FMR1_ENST00000370470.1_Missense_Mutation_p.R344G|FMR1_ENST00000440235.2_Missense_Mutation_p.R12G|FMR1_ENST00000370471.3_Missense_Mutation_p.R344G|FMR1_ENST00000370475.4_Missense_Mutation_p.R344G|FMR1_ENST00000370477.1_Missense_Mutation_p.R344G	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	344					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					CAATAATTCAAGGGTTGGACC	0.348000									Fragile X syndrome				10	86					0	0	0.435327	0	0
FAM120B	84498	broad.mit.edu	37	6	170626895	170626895	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:170626895G>T	ENST00000476287.1	+	2	525	c.417G>T	c.(415-417)gtG>gtT	p.V139V	FAM120B_ENST00000540480.1_Silent_p.V151V|FAM120B_ENST00000537664.1_Silent_p.V162V|FAM120B_ENST00000252510.9_Intron	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	139					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		GGCTAGCTGTGTTTACACGAT	0.453000													48	31					7.41606e-26	1.43739e-25	0.870114	1	0
USP21	27005	broad.mit.edu	37	1	161130660	161130660	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161130660G>T	ENST00000368002.3	+	3	607	c.230G>T	c.(229-231)cGt>cTt	p.R77L	USP21_ENST00000368001.1_Missense_Mutation_p.R77L|USP21_ENST00000289865.8_Missense_Mutation_p.R77L	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	77					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TCAGGCCCTCGTCCCAGAGGC	0.642000													11	56					1.61879e-10	2.27695e-10	0.411799	1	0
SEMA4A	64218	broad.mit.edu	37	1	156127866	156127866	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:156127866G>A	ENST00000368285.3	+	4	573	c.306G>A	c.(304-306)ccG>ccA	p.P102P	SEMA4A_ENST00000368282.1_Silent_p.P102P|SEMA4A_ENST00000368284.1_Silent_p.P3P|SEMA4A_ENST00000355014.2_Silent_p.P102P|SEMA4A_ENST00000368286.2_Silent_p.P3P|SEMA4A_ENST00000487358.1_3'UTR	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	102	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					TTCAGATACCGTGGCCAGCCA	0.493000													15	46					0	0	0.575678	0	0
ZNF239	8187	broad.mit.edu	37	10	44052834	44052834	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:44052834C>A	ENST00000306006.6	-	2	1346	c.694G>T	c.(694-696)Gaa>Taa	p.E232*	ZNF239_ENST00000535642.1_Nonsense_Mutation_p.E232*|ZNF239_ENST00000374446.2_Nonsense_Mutation_p.E232*|ZNF239_ENST00000426961.1_Nonsense_Mutation_p.E232*	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TAGGGTTTTTCTTCTGTGTGG	0.448000													10	46					9.31168e-06	1.08377e-05	0.435327	1	0
ZAN	7455	broad.mit.edu	37	7	100391493	100391493	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100391493C>T	ENST00000542585.1	+	0	8049				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACACCCTGCCCAGCATCCTGT	0.632000													26	172					0	0	0.779181	0	0
SEH1L	81929	broad.mit.edu	37	18	12982536	12982536	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:12982536G>T	ENST00000262124.11	+	7	908	c.781G>T	c.(781-783)Ggt>Tgt	p.G261C	SEH1L_ENST00000592582.1_3'UTR|SEH1L_ENST00000399892.2_Missense_Mutation_p.G261C	NM_031216.3	NP_112493.2	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	261					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						GACTTCCTCTGGTGGGCCAAC	0.358000													29	36					8.4185e-14	1.30723e-13	0.760397	1	0
MRC2	9902	broad.mit.edu	37	17	60743850	60743850	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:60743850G>T	ENST00000303375.5	+	4	1131	c.729G>T	c.(727-729)caG>caT	p.Q243H		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	243					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						ACAAGGACCAGCTGACTGACA	0.637000													20	43					3.08376e-08	3.96695e-08	0.654019	1	0
MS4A14	84689	broad.mit.edu	37	11	60183867	60183867	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:60183867G>T	ENST00000300187.6	+	5	1703	c.1426G>T	c.(1426-1428)Gaa>Taa	p.E476*	MS4A14_ENST00000531787.1_Nonsense_Mutation_p.E364*|MS4A14_ENST00000395005.2_Nonsense_Mutation_p.E459*|MS4A14_ENST00000531783.1_Nonsense_Mutation_p.E509*	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	476	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						ATCTGAGGAGGAACTCCATAG	0.383000													15	37					1.5739e-10	2.22045e-10	0.500413	1	0
SCEL	8796	broad.mit.edu	37	13	78173864	78173864	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:78173864A>T	ENST00000535157.1	+	14	1002	c.832A>T	c.(832-834)Aca>Tca	p.T278S	SCEL_ENST00000377246.3_Missense_Mutation_p.T280S|SCEL_ENST00000349847.3_Missense_Mutation_p.T300S|SCEL_ENST00000469982.1_3'UTR	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	300	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		GAGTACCCGGACAGATAAAGA	0.388000													44	23					0	0	0.870114	0	0
TACR3	6870	broad.mit.edu	37	4	104510946	104510946	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:104510946G>T	ENST00000304883.2	-	5	1431	c.1291C>A	c.(1291-1293)Cca>Aca	p.P431T	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	431						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGGTCTCTTGGCGTTGCTCTT	0.498000													59	59					1.20869e-33	2.49699e-33	0.870114	1	0
CNNM4	26504	broad.mit.edu	37	2	97427781	97427781	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:97427781G>T	ENST00000377075.2	+	1	1143	c.1045G>T	c.(1045-1047)Gag>Tag	p.E349*		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	349	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GAAGGTGACGGAGCCCTATAA	0.502000													17	89					7.45023e-12	1.09971e-11	0.592651	1	0
OR4A47	403253	broad.mit.edu	37	11	48510641	48510641	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:48510641C>A	ENST00000446524.1	+	1	373	c.297C>A	c.(295-297)ctC>ctA	p.L99L		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TGGCCCAGCTCTTTATCGAGC	0.423000													57	59					6.75472e-32	1.37878e-31	0.870114	1	0
NLRP11	204801	broad.mit.edu	37	19	56320145	56320145	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:56320145G>C	ENST00000443188.1	-	5	2541	c.1831C>G	c.(1831-1833)Cca>Gca	p.P611A	NLRP11_ENST00000589824.2_Missense_Mutation_p.P611A|NLRP11_ENST00000592953.1_Missense_Mutation_p.P512A|NLRP11_ENST00000589093.1_Missense_Mutation_p.P611A|NLRP11_ENST00000360133.3_Missense_Mutation_p.P611A	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	611							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTAGCAGTTGGCCTTATAAGT	0.413000													107	23					0	0	0.870114	0	0
KTN1	3895	broad.mit.edu	37	14	56083266	56083266	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:56083266G>A	ENST00000416613.1	+	2	627	c.555G>A	c.(553-555)atG>atA	p.M185I	KTN1_ENST00000413890.2_Missense_Mutation_p.M185I|KTN1_ENST00000395314.3_Missense_Mutation_p.M185I|KTN1_ENST00000438792.2_Missense_Mutation_p.M185I|KTN1_ENST00000395311.1_Missense_Mutation_p.M185I|KTN1_ENST00000395309.3_Missense_Mutation_p.M185I|KTN1_ENST00000395308.1_Missense_Mutation_p.M185I			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	185					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						AAACTCTCATGGTACCATCAA	0.368000			T	RET	papillary thryoid								5	30					0	0	0.217242	0	0
SYNE1	23345	broad.mit.edu	37	6	152461191	152461191	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:152461191C>A	ENST00000367255.5	-	140	25953	c.25352G>T	c.(25351-25353)aGc>aTc	p.S8451I	SYNE1_ENST00000341594.5_Missense_Mutation_p.S8063I|SYNE1_ENST00000356820.4_Missense_Mutation_p.S2975I|SYNE1_ENST00000354674.4_Missense_Mutation_p.S629I|SYNE1_ENST00000539504.1_Missense_Mutation_p.S606I|SYNE1_ENST00000423061.1_Missense_Mutation_p.S8403I|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000448038.1_Missense_Mutation_p.S8403I|SYNE1_ENST00000265368.4_Missense_Mutation_p.S8451I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8451					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCCCAGATGCTGTTCAAGTC	0.547000										HNSCC(10;0.0054)			43	77					1.30409e-13	2.01502e-13	0.870114	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119120938	119120938	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:119120938G>T	ENST00000264245.4	+	10	1871	c.1339G>T	c.(1339-1341)Gcc>Tcc	p.A447S		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	447					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CGAGCAAACAGCCCCAAAGAT	0.597000													40	92					1.57019e-19	2.79047e-19	0.834066	1	0
DNAH2	146754	broad.mit.edu	37	17	7689993	7689993	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:7689993A>T	ENST00000572933.1	+	41	7914	c.6454A>T	c.(6454-6456)Acg>Tcg	p.T2152S	DNAH2_ENST00000389173.2_Missense_Mutation_p.T2152S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2152	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGTCATGCGGACGGCATGTGC	0.557000													24	47					0	0	0.717897	0	0
HDAC9	9734	broad.mit.edu	37	7	18806777	18806777	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:18806777G>T	ENST00000406451.3	+	16	2354	c.2205_splice	c.e16+1	p.G735_splice	HDAC9_ENST00000432645.2_Splice_Site_p.G735_splice|HDAC9_ENST00000401921.1_Splice_Site_p.G694_splice|HDAC9_ENST00000441542.2_Splice_Site_p.G738_splice	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	735	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.G738V(2)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GGTGGACTTGGGGTAAGTACA	0.274000													4	26					0.00116845	0.00125586	0.217242	1	0
CACNA1S	779	broad.mit.edu	37	1	201079291	201079291	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:201079291C>A	ENST00000362061.3	-	2	485		c.e2+1		CACNA1S_ENST00000367338.3_Splice_Site	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit						axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCCAATCTTACCAGGCCGAGG	0.602000													6	102					0.00116845	0.00125586	0.217242	1	0
JPH1	56704	broad.mit.edu	37	8	75233422	75233422	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:75233422C>T	ENST00000342232.4	-	1	141	c.101G>A	c.(100-102)gGc>gAc	p.G34D	GDAP1_ENST00000521096.1_3'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	34	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTCGCCCTGGCCCTTGGGCCC	0.697000													4	44					0	0	0.217242	0	0
ZNF90	7643	broad.mit.edu	37	19	20229813	20229813	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:20229813C>G	ENST00000418063.2	+	4	1562	c.1450C>G	c.(1450-1452)Caa>Gaa	p.Q484E	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	484						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						CTACAAATGTCAAGAATGTGA	0.408000													3	4					0	0	0.150653	0	0
ADAM18	8749	broad.mit.edu	37	8	39581361	39581361	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:39581361C>A	ENST00000265707.5	+	19	2157	c.2112C>A	c.(2110-2112)acC>acA	p.T704T	ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000379866.1_Silent_p.T680T|ADAM18_ENST00000541111.1_Silent_p.T118T	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	704					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.T704T(2)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TAGTTTTCACCACTGTGATCT	0.308000													21	51					1.55795e-14	2.45771e-14	0.608945	1	0
GALNT14	79623	broad.mit.edu	37	2	31147654	31147654	+	Missense_Mutation	SNP	C	C	T	rs146467165	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:31147654C>T	ENST00000349752.5	-	12	1826	c.1187G>A	c.(1186-1188)cGc>cAc	p.R396H	GALNT14_ENST00000420311.2_Missense_Mutation_p.R361H|GALNT14_ENST00000406653.1_Missense_Mutation_p.R376H|GALNT14_ENST00000356174.3_Missense_Mutation_p.R363H|GALNT14_ENST00000324589.5_Missense_Mutation_p.R401H|GALNT14_ENST00000486564.1_Intron	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	396				R -> C (in Ref. 2; CAA70505).		Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GCTCTGGCAGCGCAGATTCTT	0.552000													32	19					0	0	0.847076	0	0
ZDHHC11	79844	broad.mit.edu	37	5	840743	840743	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:840743C>A	ENST00000283441.8	-	5	1034	c.651G>T	c.(649-651)tgG>tgT	p.W217C	ZDHHC11_ENST00000424784.2_Missense_Mutation_p.W217C|ZDHHC11_ENST00000503758.2_5'UTR|ZDHHC11_ENST00000511539.1_Missense_Mutation_p.W4C	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	217						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGAACAGCAGCCACGTGTTCA	0.587000													43	1936					1.40151e-16	2.32187e-16	0.592651	1	0
ZIC4	84107	broad.mit.edu	37	3	147114119	147114119	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:147114119C>A	ENST00000383075.3	-	3	720	c.208G>T	c.(208-210)Gac>Tac	p.D70Y	ZIC4_ENST00000425731.3_Missense_Mutation_p.D108Y|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000484399.1_Missense_Mutation_p.D70Y|ZIC4_ENST00000525172.2_Missense_Mutation_p.D120Y|ZIC4_ENST00000473123.1_Missense_Mutation_p.D70Y	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	70						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GCGTACATGTCTCCAGGGAGC	0.726000													5	13					0.000602214	0.000654747	0.184627	1	0
E4F1	1877	broad.mit.edu	37	16	2285348	2285348	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:2285348C>T	ENST00000301727.4	+	14	2178	c.2130C>T	c.(2128-2130)acC>acT	p.T710T	E4F1_ENST00000565090.1_Silent_p.T533T|E4F1_ENST00000564139.1_3'UTR	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	710					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCGCCGACACCATCACCATCG	0.682000													11	33					0	0	0.500413	0	0
OR2C3	81472	broad.mit.edu	37	1	247695507	247695507	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:247695507A>T	ENST00000366487.3	-	2	668	c.307T>A	c.(307-309)Tat>Aat	p.Y103N	GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527084.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGGGAGATATAGAACTGGACC	0.557000													8	42					0	0	0.361761	0	0
BEND6	221336	broad.mit.edu	37	6	56880067	56880067	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:56880067C>T	ENST00000370746.3	+	4	704	c.435C>T	c.(433-435)gcC>gcT	p.A145A	BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR|BEND6_ENST00000545789.1_Silent_p.A47A	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	145										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						ATTCATTTGCCTCAACATGCA	0.473000													12	226					0	0	0.435327	0	0
LRP1B	53353	broad.mit.edu	37	2	141245234	141245234	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:141245234G>T	ENST00000389484.3	-	58	10166	c.9195C>A	c.(9193-9195)ccC>ccA	p.P3065P		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3065					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GACTGCCATTGGGTCGGCTAG	0.318000										TSP Lung(27;0.18)			10	51					0.000673444	0.000729241	0.361761	1	0
PAPPA2	60676	broad.mit.edu	37	1	176664948	176664948	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:176664948G>A	ENST00000367662.3	+	7	3863	c.2699G>A	c.(2698-2700)cGg>cAg	p.R900Q		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	900					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCTTCCTCCCGGCGGGTGTGT	0.547000													12	55					0	0	0.435327	0	0
TMEM196	256130	broad.mit.edu	37	7	19765325	19765325	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19765325G>A	ENST00000405844.1	-	3	966	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W	TMEM196_ENST00000493519.1_Missense_Mutation_p.R23W|TMEM196_ENST00000433641.1_Missense_Mutation_p.R23W|TMEM196_ENST00000422233.1_Missense_Mutation_p.R23W|TMEM196_ENST00000405764.3_Missense_Mutation_p.R91W			Q5HYL7	TM196_HUMAN	transmembrane protein 196	97						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						GTGACTGCCCGGAGGAACTGA	0.498000													13	102					0	0	0.520397	0	0
KLHL1	57626	broad.mit.edu	37	13	70314605	70314605	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:70314605G>T	ENST00000377844.4	-	8	2482	c.1723C>A	c.(1723-1725)Cca>Aca	p.P575T	KLHL1_ENST00000545028.1_Missense_Mutation_p.P382T	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	575					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TGACTCTGTGGATCCCACCTT	0.408000													10	107					5.50884e-06	6.43952e-06	0.411799	1	0
OR56A1	120796	broad.mit.edu	37	11	6048589	6048589	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:6048589G>A	ENST00000316650.5	-	1	382	c.346C>T	c.(346-348)Ccc>Tcc	p.P116S		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACTCCATGGGGAGGAAACTG	0.522000													15	35					0	0	0.539581	0	0
GYPC	2995	broad.mit.edu	37	2	127453597	127453597	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:127453597G>T	ENST00000259254.4	+	4	597	c.266G>T	c.(265-267)gGc>gTc	p.G89V	GYPC_ENST00000464053.1_3'UTR|GYPC_ENST00000409836.3_Missense_Mutation_p.G70V|GYPC_ENST00000356887.7_Missense_Mutation_p.G68V	NM_002101.4	NP_002092.1	P04921	GLPC_HUMAN	glycophorin C (Gerbich blood group)	89						cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|prostate(2)|urinary_tract(1)	13	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CGGCACAAGGGCACGTACCAC	0.597000													69	83					4.8811e-34	1.00948e-33	0.870114	1	0
SSPO	23145	broad.mit.edu	37	7	149493807	149493807	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:149493807G>T	ENST00000378016.2	+	0	6803							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGGGCTGTGTGTTGCTG	0.657000													10	15					0.00244969	0.00261208	0.457914	1	0
REM1	28954	broad.mit.edu	37	20	30064507	30064507	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:30064507G>A	ENST00000201979.2	+	2	552	c.259G>A	c.(259-261)Gga>Aga	p.G87R	DEFB124_ENST00000481595.1_5'UTR	NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	87					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGTGCTACTTGGAGATCCTGG	0.587000													17	46					0	0	0.592651	0	0
LRFN2	57497	broad.mit.edu	37	6	40400618	40400618	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:40400618C>T	ENST00000338305.6	-	2	777	c.235G>A	c.(235-237)Gtg>Atg	p.V79M		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	79						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTCAGGTCCACCAGCCCCGTC	0.597000													5	62					0	0	0.184627	0	0
TEAD4	7004	broad.mit.edu	37	12	3126691	3126691	+	Splice_Site	SNP	G	G	T	rs149743004	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:3126691G>T	ENST00000359864.2	+	6	672	c.483_splice	c.e6+1	p.G161_splice	TEAD4_ENST00000358409.2_Intron|TEAD4_ENST00000397122.2_Splice_Site_p.G32_splice	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	161					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GCAGTCTCAGGGGTAAGTGGG	0.652000													5	10					0.000602214	0.000654747	0.184627	1	0
LAMB1	3912	broad.mit.edu	37	7	107615733	107615733	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:107615733C>A	ENST00000393561.1	-	9	1571	c.1387G>T	c.(1387-1389)Gtt>Ttt	p.V463F	LAMB1_ENST00000222399.6_Missense_Mutation_p.V439F|LAMB1_ENST00000393560.1_Missense_Mutation_p.V439F			P07942	LAMB1_HUMAN	laminin, beta 1	439	Laminin EGF-like 4.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTTGCAAACATCACAATGT	0.368000													17	67					5.35356e-11	7.65026e-11	0.639603	1	0
GDF9	2661	broad.mit.edu	37	5	132197523	132197523	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:132197523G>A	ENST00000378673.2	-	3	1989	c.1123C>T	c.(1123-1125)Cac>Tac	p.H375Y	GDF9_ENST00000296875.2_Missense_Mutation_p.H375Y			O60383	GDF9_HUMAN	growth differentiation factor 9	375					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGTACCTGTGCGGAGCCACA	0.468000													25	16					0	0	0.760397	0	0
RP3-331H24.5	0	broad.mit.edu	37	6	72086704	72086704	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:72086704C>A	ENST00000602823.1	-	0	267				MIR30C2_ENST00000362224.1_RNA																							TTACTTTCCACAGCTGAGAGT	0.433000													27	67					1.22384e-17	2.0844e-17	0.769981	1	0
ASH1L	55870	broad.mit.edu	37	1	155324311	155324311	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:155324311T>A	ENST00000368346.3	-	16	7820	c.7181A>T	c.(7180-7182)tAt>tTt	p.Y2394F	ASH1L_ENST00000392403.3_Missense_Mutation_p.Y2389F			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2394					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CCAACGGGTATATAATGATGC	0.393000													88	351					0	0	0.870114	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203548	140203548	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140203548G>T	ENST00000529859.1	+	1	2188	c.2188G>T	c.(2188-2190)Gtg>Ttg	p.V730L	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.V730L|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.V730L	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGAGGCCGTGTGCACACG	0.667000													20	56					4.54149e-19	7.96559e-19	0.624587	1	0
PAPPA2	60676	broad.mit.edu	37	1	176564447	176564447	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:176564447C>A	ENST00000367662.3	+	3	2871	c.1707C>A	c.(1705-1707)gtC>gtA	p.V569V	PAPPA2_ENST00000367661.3_Silent_p.V569V	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	569	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.V569V(4)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGCTGAGCGTCCACCAGGTCC	0.572000													12	90					1.3612e-06	1.64112e-06	0.479597	1	0
PTPRB	5787	broad.mit.edu	37	12	70928312	70928312	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:70928312G>T	ENST00000334414.6	-	31	6368	c.6324C>A	c.(6322-6324)taC>taA	p.Y2108*	PTPRB_ENST00000550358.1_Nonsense_Mutation_p.Y2020*|PTPRB_ENST00000261266.5_Nonsense_Mutation_p.Y1890*|PTPRB_ENST00000451516.2_Nonsense_Mutation_p.Y1800*|PTPRB_ENST00000550857.1_Nonsense_Mutation_p.Y1800*|RP11-588H23.3_ENST00000546836.1_RNA|PTPRB_ENST00000538708.1_Nonsense_Mutation_p.Y1800*|RP11-588H23.3_ENST00000547656.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA|RP11-588H23.3_ENST00000549460.1_RNA|RP11-588H23.3_ENST00000548687.1_RNA	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1890					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTCTGTTGATGTAGTCCCTGA	0.547000													6	25					0.0293803	0.0301822	0.248553	1	0
HDAC9	9734	broad.mit.edu	37	7	18669011	18669011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:18669011C>T	ENST00000406451.3	+	7	844	c.694C>T	c.(694-696)Cag>Tag	p.Q232*	HDAC9_ENST00000432645.2_Nonsense_Mutation_p.Q232*|HDAC9_ENST00000405010.3_Nonsense_Mutation_p.Q232*|HDAC9_ENST00000401921.1_Intron|HDAC9_ENST00000417496.2_Intron|HDAC9_ENST00000406072.1_Intron|HDAC9_ENST00000524023.1_Intron|HDAC9_ENST00000456174.2_Nonsense_Mutation_p.Q204*|HDAC9_ENST00000428307.2_Intron|HDAC9_ENST00000441542.2_Nonsense_Mutation_p.Q235*	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	232	Interaction with ETV6.|Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CAGGTTAAAACAGAAAGTGGC	0.418000													8	28					0	0	0.278610	0	0
NEIL2	252969	broad.mit.edu	37	8	11643643	11643643	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:11643643A>T	ENST00000284503.6	+	5	1459	c.860A>T	c.(859-861)cAg>cTg	p.Q287L	NEIL2_ENST00000403422.3_Missense_Mutation_p.Q226L|NEIL2_ENST00000436750.3_Missense_Mutation_p.Q287L|NEIL2_ENST00000455213.2_Missense_Mutation_p.Q287L|NEIL2_ENST00000528323.1_Missense_Mutation_p.Q171L	NM_145043.2	NP_659480.1	Q969S2	NEIL2_HUMAN	nei endonuclease VIII-like 2 (E. coli)	287					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CAGGTCTACCAGAAAGAACAG	0.627000								Base excision repair (BER), DNA glycosylases					4	18					0	0	0.150653	0	0
UNC5D	137970	broad.mit.edu	37	8	35624420	35624420	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:35624420G>T	ENST00000287272.2	+	14	2127	c.2106_splice	c.e14-1	p.E703_splice	UNC5D_ENST00000449677.1_Splice_Site_p.E348_splice|UNC5D_ENST00000404895.2_Splice_Site_p.E772_splice|UNC5D_ENST00000416672.1_Splice_Site_p.E777_splice|UNC5D_ENST00000453357.2_Splice_Site_p.E767_splice|UNC5D_ENST00000420357.1_Splice_Site_p.E705_splice			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	772	Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TCCCCTGCAGGAAGTCCCGTT	0.562000													21	44					7.38237e-10	1.00898e-09	0.706142	1	0
IGJ	3512	broad.mit.edu	37	4	71532178	71532178	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:71532178G>T	ENST00000254801.4	-	1	199	c.30C>A	c.(28-30)gtC>gtA	p.V10V	ENAM_ENST00000472903.1_Intron|IGJ_ENST00000543780.1_Silent_p.V10V	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	10					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			AAACCGCCAGGACTCCCCAGA	0.373000													9	21					1.61879e-10	2.27695e-10	0.411799	1	0
OR11A1	26531	broad.mit.edu	37	6	29394919	29394919	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:29394919A>T	ENST00000377149.1	-	5	972	c.500T>A	c.(499-501)cTg>cAg	p.L167Q	OR11A1_ENST00000377148.1_Missense_Mutation_p.L167Q|OR5V1_ENST00000377154.1_Intron|OR11A1_ENST00000377147.2_Missense_Mutation_p.L167Q			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						ACAGAACCTCAGCTGGGCCAC	0.572000													11	44					0	0	0.435327	0	0
PEX16	9409	broad.mit.edu	37	11	45937333	45937333	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:45937333C>A	ENST00000241041.3	-	4	297	c.280G>T	c.(280-282)Gtg>Ttg	p.V94L	PEX16_ENST00000378750.5_Missense_Mutation_p.V94L|PEX16_ENST00000532681.1_5'UTR|PEX16_ENST00000532554.1_Intron	NM_004813.2|NM_057174.2	NP_004804.1|NP_476515.1	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16	94					ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			large_intestine(2)|lung(2)|ovary(2)|skin(1)	7				GBM - Glioblastoma multiforme(35;0.223)		TCCATGAACACCTCCACGCAC	0.617000													41	238					9.22156e-22	1.70817e-21	0.870114	1	0
FRMD7	90167	broad.mit.edu	37	X	131214236	131214236	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:131214236G>A	ENST00000298542.4	-	10	1139	c.964C>T	c.(964-966)Cca>Tca	p.P322S	FRMD7_ENST00000464296.1_Missense_Mutation_p.P307S|FRMD7_ENST00000370879.1_Missense_Mutation_p.P202S	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	322					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTTTCAAATGGCAAGCTCTTC	0.368000													8	41					0	0	0.335167	0	0
LGALS16	148003	broad.mit.edu	37	19	40149183	40149183	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:40149183G>T	ENST00000392051.3	+	3	244	c.176G>T	c.(175-177)gGc>gTc	p.G59V		NM_001190441.1	NP_001177370.1	A8MUM7	A8MUM7_HUMAN	lectin, galactoside-binding, soluble, 16	59							sugar binding										GTGCACTTAGGCCGTCGTGTG	0.488000													16	7					1.99824e-07	2.49217e-07	0.520397	1	0
IGHV1-58	28464	broad.mit.edu	37	14	107078791	107078791	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:107078791C>A	ENST00000390628.2	-	0	78																											AGAAGAGGACCCTCCAAATCC	0.542000													41	105					6.32628e-17	1.05926e-16	0.870114	1	0
KLHL28	54813	broad.mit.edu	37	14	45414261	45414261	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:45414261T>A	ENST00000396128.4	-	2	990	c.871A>T	c.(871-873)Aaa>Taa	p.K291*	KLHL28_ENST00000355081.2_Nonsense_Mutation_p.K305*	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	291										breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						AGTCCAGATTTCCCTCCTACT	0.393000													12	97					0	0	0.520397	0	0
NLRP8	126205	broad.mit.edu	37	19	56465930	56465930	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:56465930C>A	ENST00000291971.3	+	3	577	c.506C>A	c.(505-507)aCt>aAt	p.T169N	NLRP8_ENST00000590542.1_Missense_Mutation_p.T169N	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	169						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACATTACGACTTGGCCTGGA	0.458000													157	25					2.88717e-64	6.49959e-64	0.870114	1	0
EPHB1	2047	broad.mit.edu	37	3	134851755	134851755	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:134851755G>C	ENST00000398015.3	+	5	1531	c.1161G>C	c.(1159-1161)acG>acC	p.T387T	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	387	Fibronectin type-III 1.		T -> M (in dbSNP:rs56396912).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.T387T(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TGGGCCTGACGGAGTGCCGCG	0.612000													19	21					0	0	0.575678	0	0
BRINP3	339479	broad.mit.edu	37	1	190195299	190195299	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:190195299G>T	ENST00000367462.3	-	6	1105	c.874C>A	c.(874-876)Ccc>Acc	p.P292T	FAM5C_ENST00000534846.1_Missense_Mutation_p.P190T|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		292						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TCCATGGAGGGGCAGTTGCAT	0.433000													14	72					1.02788e-11	1.5066e-11	0.520397	1	0
USP6	9098	broad.mit.edu	37	17	5071268	5071268	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:5071268G>A	ENST00000574788.1	+	34	5308	c.3078G>A	c.(3076-3078)gcG>gcA	p.A1026A	USP6_ENST00000304328.5_Silent_p.A709A|USP6_ENST00000250066.6_Silent_p.A1026A|USP6_ENST00000332776.4_3'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	1026					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GTCGGCGAGCGCAAGCCGAGC	0.527000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								13	45					0	0	0.435327	0	0
DDX31	64794	broad.mit.edu	37	9	135522389	135522389	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:135522389C>A	ENST00000372159.3	-	12	1490	c.1339G>T	c.(1339-1341)Gac>Tac	p.D447Y	DDX31_ENST00000438527.3_Missense_Mutation_p.D318Y|DDX31_ENST00000310532.2_Missense_Mutation_p.D447Y|DDX31_ENST00000372153.1_Missense_Mutation_p.D447Y	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	447						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		TGGCTCTTGTCCAGGACAGAA	0.498000													42	49					9.57592e-29	1.91926e-28	0.870114	1	0
MED12	9968	broad.mit.edu	37	X	70360628	70360628	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:70360628A>G	ENST00000333646.6	+	42	6396	c.6197A>G	c.(6196-6198)cAg>cGg	p.Q2066R	MED12_ENST00000478889.1_3'UTR|MED12_ENST00000374080.3_Missense_Mutation_p.Q2063R|MED12_ENST00000374102.1_Missense_Mutation_p.Q2062R	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	2063	Gln-rich.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					cagcaacagcagcagcagcag	0.597000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						11	45					0	0	0.361761	0	0
TTC9C	283237	broad.mit.edu	37	11	62496379	62496379	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:62496379G>A	ENST00000513247.2	+	2	710	c.458G>A	c.(457-459)cGg>cAg	p.R153Q	TTC9C_ENST00000316461.4_Missense_Mutation_p.R20Q|TTC9C_ENST00000532583.1_Missense_Mutation_p.R20Q			Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	20							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						CAGCGCTACCGGGAAGGGAAG	0.577000													29	53					0	0	0.769981	0	0
MAL2	114569	broad.mit.edu	37	8	120233847	120233847	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:120233847G>T	ENST00000276681.6	+	3	255	c.153G>T	c.(151-153)tgG>tgT	p.W51C	MAL2_ENST00000521748.1_3'UTR|RP11-4K16.2_ENST00000522828.1_lincRNA	NM_052886.2	NP_443118.1	Q969L2	MAL2_HUMAN	mal, T-cell differentiation protein 2 (gene/pseudogene)	51	MARVEL.					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding					all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			GTCTTGTCTGGATTTTGGTTG	0.433000													120	222					1.73756e-106	3.98306e-106	0.870114	1	0
ZNF566	84924	broad.mit.edu	37	19	36940581	36940581	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:36940581C>A	ENST00000454319.1	-	5	692	c.558G>T	c.(556-558)caG>caT	p.Q186H	ZNF566_ENST00000493391.1_Missense_Mutation_p.Q81H|ZNF566_ENST00000434377.2_Missense_Mutation_p.Q185H|ZNF566_ENST00000392170.2_Missense_Mutation_p.Q186H|ZNF566_ENST00000424129.2_Missense_Mutation_p.Q185H	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					GTGTAGCAAACTGTGAGCCAT	0.368000													11	50					3.07112e-06	3.6397e-06	0.387290	1	0
CAPS	828	broad.mit.edu	37	19	5914579	5914579	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:5914579T>C	ENST00000588776.1	+	3	2714	c.347T>C	c.(346-348)tTc>tCc	p.F116S	CAPS_ENST00000222125.5_Missense_Mutation_p.F30S|AC104532.2_ENST00000588891.1_3'UTR|CAPS_ENST00000452990.2_Missense_Mutation_p.F30S			Q13938	CAYP1_HUMAN	calcyphosine	30	EF-hand 3.				intracellular signal transduction	cytoplasm	calcium ion binding			cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	4						TCCAGGTTTTTCCGCCAACTA	0.662000													6	57					0	0	0.307466	0	0
GABRA2	2555	broad.mit.edu	37	4	46307700	46307700	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:46307700A>T	ENST00000510861.1	-	7	761	c.588T>A	c.(586-588)taT>taA	p.Y196*	GABRA2_ENST00000381620.4_Nonsense_Mutation_p.Y196*|GABRA2_ENST00000540012.1_Nonsense_Mutation_p.Y141*|GABRA2_ENST00000514090.1_Nonsense_Mutation_p.Y196*|GABRA2_ENST00000515082.1_Nonsense_Mutation_p.Y196*|GABRA2_ENST00000356504.1_Nonsense_Mutation_p.Y196*|GABRA2_ENST00000507069.1_Nonsense_Mutation_p.Y196*			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	196					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGTCCAAATATAAGTGACCT	0.378000													19	38					0	0	0.639603	0	0
BNC2	54796	broad.mit.edu	37	9	16436625	16436625	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:16436625C>T	ENST00000380672.4	-	6	1624	c.1567G>A	c.(1567-1569)Gca>Aca	p.A523T	BNC2_ENST00000380667.2_Missense_Mutation_p.A456T|BNC2_ENST00000545497.1_Missense_Mutation_p.A428T|BNC2_ENST00000380666.2_Missense_Mutation_p.A523T	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		TTTGTACTTGCTATGACAGGG	0.512000													71	63					0	0	0.870114	0	0
VAV3	10451	broad.mit.edu	37	1	108116777	108116777	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:108116777G>T	ENST00000370056.4	-	26	2668	c.2394C>A	c.(2392-2394)gaC>gaA	p.D798E	VAV3_ENST00000415432.2_Missense_Mutation_p.D238E|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000544443.1_Missense_Mutation_p.D202E|VAV3_ENST00000527011.1_Missense_Mutation_p.D826E	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	798	SH3 2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTGCACAGAAGTCATACCGAG	0.428000													16	106					0.000958276	0.00103648	0.557998	1	0
ANGPT1	284	broad.mit.edu	37	8	108334178	108334178	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:108334178G>A	ENST00000520734.1	-	3	439	c.154C>T	c.(154-156)Ctg>Ttg	p.L52L	ANGPT1_ENST00000518386.1_5'UTR|ANGPT1_ENST00000520052.1_Silent_p.L52L			Q15389	ANGP1_HUMAN	angiopoietin 1	252					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			ATCAGCTCCAGTTGCTGCTTC	0.408000													22	103					0	0	0.693898	0	0
ENOX2	10495	broad.mit.edu	37	X	129813550	129813550	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:129813550C>T	ENST00000338144.3	-	7	930	c.513G>A	c.(511-513)gaG>gaA	p.E171E	ENOX2_ENST00000370927.1_Silent_p.E171E|ENOX2_ENST00000370935.1_Silent_p.E142E|ENOX2_ENST00000394363.1_Silent_p.E142E	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	171	RRM.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						CCATGTACTCCTCAGCAAAGC	0.453000													35	139					0	0	0.859065	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142020943	142020943	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142020943G>T	ENST00000390381.3	+	0	358																											CTGGGAGCAGGTGAGTCCCTG	0.617000													7	19					0.00829132	0.00869318	0.361761	1	0
GZMB	3002	broad.mit.edu	37	14	25101178	25101178	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:25101178C>A	ENST00000216341.4	-	4	592	c.486G>T	c.(484-486)gaG>gaT	p.E162D	GZMB_ENST00000382542.1_Missense_Mutation_p.E196D|GZMB_ENST00000382540.1_Missense_Mutation_p.E117D|RP11-104E19.1_ENST00000557736.1_RNA|RP11-104E19.1_ENST00000555300.1_RNA|GZMB_ENST00000526004.1_3'UTR|GZMB_ENST00000415355.3_Missense_Mutation_p.E150D			P10144	GRAB_HUMAN	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	162	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(4)|stomach(4)|urinary_tract(2)	13				GBM - Glioblastoma multiforme(265;0.028)		TCATCTTCACCTCTTGTAGTG	0.537000													31	80					9.45814e-24	1.80164e-23	0.804634	1	0
BAZ1B	9031	broad.mit.edu	37	7	72892675	72892675	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:72892675C>G	ENST00000339594.4	-	7	1454	c.1116G>C	c.(1114-1116)atG>atC	p.M372I	BAZ1B_ENST00000404251.1_Missense_Mutation_p.M372I	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	372	Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGGGCGACATCATCTTCATCA	0.438000													18	34					0	0	0.520397	0	0
GPR21	2844	broad.mit.edu	37	9	125797760	125797760	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:125797760T>C	ENST00000373642.1	+	1	955	c.915T>C	c.(913-915)agT>agC	p.S305S	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000493854.1_Intron|RABGAP1_ENST00000373643.5_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	305						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						TAATTTATAGTCTCTCCAACA	0.468000													19	41					0	0	0.557998	0	0
NABP1	64859	broad.mit.edu	37	2	192543389	192543389	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:192543389G>A	ENST00000425611.2	+	1	132	c.49G>A	c.(49-51)Gga>Aga	p.G17R	NABP1_ENST00000409510.1_Intron|NABP1_ENST00000410026.1_Intron					nucleic acid binding protein 1																		TATTAAGCCCGGACTGAAAAA	0.552000													29	29					0	0	0.779181	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67214273	67214273	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:67214273C>A	ENST00000290881.7	-	3	1167	c.241G>T	c.(241-243)Gag>Tag	p.E81*	KIAA0895L_ENST00000563902.1_Nonsense_Mutation_p.E81*|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000561621.1_Nonsense_Mutation_p.E81*			Q68EN5	K895L_HUMAN	KIAA0895-like	81										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						TAGGTGCTCTCACTGCGACGC	0.697000													9	6					2.27111e-07	2.82127e-07	0.411799	1	0
SELV	348303	broad.mit.edu	37	19	40009409	40009409	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:40009409G>T	ENST00000423711.1	+	4	964	c.864G>T	c.(862-864)caG>caT	p.Q288H	SELV_ENST00000335426.4_Missense_Mutation_p.Q288H			P59797	SELV_HUMAN		288					cell redox homeostasis		selenium binding			breast(1)|endometrium(1)|lung(3)|prostate(1)	6	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCCTGGAGCAGCAATTTCCGA	0.577000													11	56					1.3612e-06	1.64112e-06	0.479597	1	0
DBF4	10926	broad.mit.edu	37	7	87516659	87516659	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:87516659A>T	ENST00000265728.1	+	5	970	c.466A>T	c.(466-468)Aat>Tat	p.N156Y		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	156	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TATTCCTTCAAATAGTATATT	0.234000													10	9					0	0	0.411799	0	0
FAM47A	158724	broad.mit.edu	37	X	34149265	34149265	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:34149265C>A	ENST00000346193.3	-	1	1182	c.1131G>T	c.(1129-1131)gcG>gcT	p.A377A		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	377			A -> S (in dbSNP:rs1811716).							NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TGGAAGGCTCCGCGTGGAGAC	0.642000													19	17					4.35082e-09	5.82793e-09	0.592651	1	0
CRY2	1408	broad.mit.edu	37	11	45893643	45893643	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:45893643G>T	ENST00000443527.2	+	11	1728	c.1705_splice	c.e11-1	p.G569_splice	CRY2_ENST00000417225.2_Splice_Site_p.G487_splice	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	548					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						TTCCCTACAGGCCCAAGACCA	0.582000													15	83					3.51602e-12	5.24754e-12	0.575678	1	0
NR0B1	190	broad.mit.edu	37	X	30322843	30322843	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:30322843G>A	ENST00000378970.4	-	2	1500	c.1266C>T	c.(1264-1266)ccC>ccT	p.P422P		NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	422	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	ATCTGTCATGGGGCCCTTGGT	0.512000													36	49					0	0	0.834066	0	0
COL4A2	1284	broad.mit.edu	37	13	111119402	111119402	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:111119402C>A	ENST00000360467.5	+	27	2360	c.2054C>A	c.(2053-2055)cCc>cAc	p.P685H		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	685	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			ATAGGAGGGCCCAAGGGATTG	0.592000													19	1232					1.15088e-07	1.44013e-07	0.500413	1	0
DENND6A	201627	broad.mit.edu	37	3	57643458	57643458	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:57643458T>A	ENST00000311128.5	-	9	837	c.767A>T	c.(766-768)gAc>gTc	p.D256V		NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		TATATTTGTGTCCACCTGAGA	0.303000													10	10					0	0	0.435327	0	0
INHBA	3624	broad.mit.edu	37	7	41729680	41729680	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:41729680C>A	ENST00000242208.4	-	3	1095	c.849G>T	c.(847-849)gaG>gaT	p.E283D	INHBA_ENST00000442711.1_Missense_Mutation_p.E283D|INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	283					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						gctccttttcctcatctgctc	0.602000										TSP Lung(11;0.080)			19	43					2.54575e-18	4.40358e-18	0.592651	1	0
IFNE	338376	broad.mit.edu	37	9	21481077	21481077	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:21481077C>T	ENST00000448696.3	-	1	1235	c.617G>A	c.(616-618)aGc>aAc	p.S206N	MIR31HG_ENST00000304425.3_RNA	NM_176891.4	NP_795372.1	Q86WN2	IFNE_HUMAN	interferon, epsilon	206					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(2)|lung(1)|skin(1)	4						CTACCTCGGGCTTCTAAACTC	0.413000													6	121					0	0	0.278610	0	0
OR1E2	8388	broad.mit.edu	37	17	3336696	3336696	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:3336696G>T	ENST00000248384.1	-	1	439	c.440C>A	c.(439-441)cCc>cAc	p.P147H		NM_003554.1	NP_003545.1	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E, member 2	147					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)	9						ACAGAGCATGGGGCTCATGAT	0.567000													34	17					2.05212e-20	3.71355e-20	0.812448	1	0
SELV	348303	broad.mit.edu	37	19	40009595	40009595	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:40009595G>T	ENST00000423711.1	+	5	1041	c.941G>T	c.(940-942)gGg>gTg	p.G314V	SELV_ENST00000335426.4_Missense_Mutation_p.G314V			P59797	SELV_HUMAN		314					cell redox homeostasis		selenium binding			breast(1)|endometrium(1)|lung(3)|prostate(1)	6	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TTTGTGAACGGGAGACTGGTC	0.587000													28	167					8.73648e-17	1.45248e-16	0.796494	1	0
PKD1L2	114780	broad.mit.edu	37	16	81228566	81228566	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:81228566G>T	ENST00000599697.1	-	8	1607	c.1608C>A	c.(1606-1608)aaC>aaA	p.N536K	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	536	REJ.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TGATAGTGATGTTCCCGATTT	0.512000													34	19					5.73435e-26	1.11258e-25	0.870114	1	0
CST4	1472	broad.mit.edu	37	20	23667729	23667729	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:23667729T>G	ENST00000217423.3	-	2	408	c.338A>C	c.(337-339)cAg>cCg	p.Q113P		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	113						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					ACGTACCTTCTGCAGTTCTGG	0.567000													40	128					0	0	0.870114	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576252	158576252	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158576252C>A	ENST00000361284.1	+	1	24	c.24C>A	c.(22-24)tcC>tcA	p.S8S		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					ACGTAACCTCCTGGAGGGATT	0.478000													19	202					3.6726e-16	6.02076e-16	0.667858	1	0
BTN2A1	11120	broad.mit.edu	37	6	26468740	26468740	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:26468740T>C	ENST00000312541.5	+	8	1795	c.1547T>C	c.(1546-1548)cTg>cCg	p.L516P	BTN2A1_ENST00000429381.1_3'UTR|BTN2A1_ENST00000469185.1_Intron|BTN2A1_ENST00000541522.1_Missense_Mutation_p.L455P	NM_007049.3|NM_078476.2	NP_008980.1|NP_510961.1	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	516					lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						GAAGAGGGCCTGACACTTCAC	0.577000													4	147					0	0	0.217242	0	0
HHAT	55733	broad.mit.edu	37	1	210847698	210847698	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:210847698G>A	ENST00000367010.1	+	12	1686	c.1459G>A	c.(1459-1461)Gcc>Acc	p.A487T	HHAT_ENST00000545154.1_Missense_Mutation_p.A488T|HHAT_ENST00000541565.1_Missense_Mutation_p.A350T|HHAT_ENST00000537898.1_Missense_Mutation_p.A422T|HHAT_ENST00000545781.1_Missense_Mutation_p.A424T|HHAT_ENST00000367009.1_Missense_Mutation_p.A177T|HHAT_ENST00000308852.6_Missense_Mutation_p.A442T|HHAT_ENST00000261458.3_Missense_Mutation_p.A487T|HHAT_ENST00000413764.2_Missense_Mutation_p.A487T	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	487					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		CATTGCCTGGGCCCAGACCTA	0.597000													24	91					0	0	0.729181	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22786107	22786107	+	RNA	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22786107C>G	ENST00000599738.1	+	0	37				CTC-457E21.3_ENST00000600260.1_RNA																							CCCCAGTGCACAGCAGATCAT	0.592000													5	4					0	0	0.278610	0	0
CLCN5	1184	broad.mit.edu	37	X	49834576	49834576	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:49834576G>C	ENST00000376088.3	+	5	847	c.206G>C	c.(205-207)aGg>aCg	p.R69T	CLCN5_ENST00000376091.3_Missense_Mutation_p.R69T|CLCN5_ENST00000307367.2_5'UTR|CLCN5_ENST00000376108.3_5'UTR	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	0					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					TCTTCAAATAGGATCATGGAC	0.398000													7	17					0	0	0.307466	0	0
KRT16P3	644945	broad.mit.edu	37	17	20407334	20407334	+	RNA	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:20407334T>G	ENST00000580113.1	-	0	305																											AGCACGCACCTTGTCCAGGTA	0.612000													19	145					0	0	0.706142	0	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													3	73					0	0	0.115264	0	0
PRKCQ	5588	broad.mit.edu	37	10	6506333	6506333	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:6506333C>T	ENST00000263125.5	-	13	1486	c.1387G>A	c.(1387-1389)Gga>Aga	p.G463R	PRKCQ_ENST00000397176.2_Missense_Mutation_p.G463R|PRKCQ_ENST00000539722.1_Missense_Mutation_p.G338R	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	463	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity	p.G463*(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						AAGTCCCCTCCGTTGAGGTAC	0.383000													6	272					0	0	0.217242	0	0
CDX4	1046	broad.mit.edu	37	X	72674301	72674301	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:72674301G>T	ENST00000373514.2	+	3	735	c.735G>T	c.(733-735)tcG>tcT	p.S245S		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					GTGGAGGCTCGGTGCAAAGTG	0.448000													11	22					0.435327	0.43812	0.435327	1	0
H2BFWT	158983	broad.mit.edu	37	X	103267315	103267315	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:103267315G>A	ENST00000217926.5	-	2	523	c.497C>T	c.(496-498)tCa>tTa	p.S166L		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	166					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						ggcatacagtgaagttctgga	0.408000													12	96					0	0	0.479597	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6087218	6087218	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:6087218G>T	ENST00000409021.3	-	4	1212	c.763C>A	c.(763-765)Cgg>Agg	p.R255R	JAKMIP1_ENST00000410077.2_Silent_p.R90R|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Silent_p.R255R|JAKMIP1_ENST00000409831.1_Silent_p.R255R|JAKMIP1_ENST00000409371.3_Silent_p.R90R	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	255	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTGTGGTGCCGCTCGGCCTCC	0.617000													33	41					2.08457e-15	3.3474e-15	0.750413	1	0
ZNF804B	219578	broad.mit.edu	37	7	88966269	88966269	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:88966269C>A	ENST00000333190.4	+	4	4582	c.3973C>A	c.(3973-3975)Cat>Aat	p.H1325N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1325						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGATTTTTGCCATCATTCTTG	0.403000										HNSCC(36;0.09)			46	132					3.05275e-18	5.27573e-18	0.864702	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188676	140188676	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140188676G>T	ENST00000530339.1	+	1	1904	c.1904G>T	c.(1903-1905)cGt>cTt	p.R635L	PCDHA4_ENST00000356878.4_Missense_Mutation_p.R635L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.R635L|PCDHA1_ENST00000504120.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACAACGCGTGCCCTGGAC	0.682000													118	83					2.23578e-59	5.00921e-59	0.870114	1	0
MUC16	94025	broad.mit.edu	37	19	9000511	9000511	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:9000511C>A	ENST00000397910.4	-	54	40676	c.40473G>T	c.(40471-40473)cgG>cgT	p.R13491R	MUC16_ENST00000380951.5_Silent_p.R132R	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13493	SEA 10.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCCTCATACCGCAGGTTAG	0.473000													28	78					8.16721e-17	1.36024e-16	0.750413	1	0
NXF3	56000	broad.mit.edu	37	X	102334545	102334545	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:102334545C>G	ENST00000395065.3	-	14	1287	c.1186G>C	c.(1186-1188)Gat>Cat	p.D396H	NXF3_ENST00000497850.1_5'UTR|NXF3_ENST00000425644.1_Missense_Mutation_p.D68H	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	396	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TTCCTGCTATCCTTGAAGAAC	0.512000													50	118					0	0	0.870114	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336692	42336692	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:42336692G>T	ENST00000262418.6	-	9	870	c.715C>A	c.(715-717)Cag>Aag	p.Q239K	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	239					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		AGCACCGGCTGCTCCAGGAAG	0.662000													9	9					0.00829132	0.00869318	0.361761	1	0
NPAT	4863	broad.mit.edu	37	11	108057289	108057289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:108057289G>A	ENST00000278612.8	-	8	751	c.646C>T	c.(646-648)Cag>Tag	p.Q216*		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	216	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		CTTTTTCTCTGAGATTCACTG	0.318000													19	43					0	0	0.608945	0	0
ENGASE	64772	broad.mit.edu	37	17	77082261	77082261	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:77082261G>T	ENST00000579016.1	+	14	2062	c.2062G>T	c.(2062-2064)Ggg>Tgg	p.G688W		NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	688						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						CATGTTCCTGGGGTTGGCTTT	0.627000													42	14					8.20599e-20	1.46803e-19	0.859065	1	0
ZBTB14	7541	broad.mit.edu	37	18	5291963	5291963	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:5291963G>A	ENST00000357006.4	-	4	582	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	ZBTB14_ENST00000400143.3_Missense_Mutation_p.R82C	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		ATATCAGAACGAAGAAAATCT	0.373000													7	26					0	0	0.248553	0	0
FEV	54738	broad.mit.edu	37	2	219846738	219846738	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:219846738G>A	ENST00000295727.1	-	3	949	c.368C>T	c.(367-369)gCc>gTc	p.A123V		NM_017521.2	NP_059991.1	Q99581	FEV_HUMAN	FEV (ETS oncogene family)	123					cell differentiation|nervous system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity		EWSR1/FEV(11)|FUS/FEV(2)	large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAAGCGGTAGGCGTAGCGCTT	0.682000			T	"""EWSR1,  FUS"""	Ewing sarcoma								13	21					0	0	0.457914	0	0
C1orf173	127254	broad.mit.edu	37	1	75037596	75037596	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:75037596G>A	ENST00000326665.5	-	14	4016	c.3798C>T	c.(3796-3798)gtC>gtT	p.V1266V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1266	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCTTAGCACGACATCCACTC	0.577000													33	88					0	0	0.827153	0	0
SLC10A3	8273	broad.mit.edu	37	X	153717296	153717296	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153717296C>A	ENST00000393586.1	-	3	246	c.149G>T	c.(148-150)cGt>cTt	p.R50L	SLC10A3_ENST00000393587.4_5'UTR|SLC10A3_ENST00000369649.4_5'UTR|SLC10A3_ENST00000263512.4_5'UTR			P09131	P3_HUMAN	solute carrier family 10, member 3	59					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTGGAGGACGGATGGCGTG	0.617000													4	15					0.150653	0.152846	0.150653	1	0
ERGIC3	51614	broad.mit.edu	37	20	34129923	34129923	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:34129923G>T	ENST00000348547.2	+	1	154	c.77G>T	c.(76-78)gGg>gTg	p.G26V	ERGIC3_ENST00000279052.6_Missense_Mutation_p.G26V|ERGIC3_ENST00000447986.1_Missense_Mutation_p.G26V|ERGIC3_ENST00000357394.4_Missense_Mutation_p.G26V	NM_015966.2	NP_057050.1	Q9Y282	ERGI3_HUMAN	ERGIC and golgi 3	26					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)	16	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			AAGACCTGCGGGGGCGCCACC	0.697000													12	20					1.5842e-08	2.06902e-08	0.435327	1	0
KIT	3815	broad.mit.edu	37	4	55569912	55569912	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:55569912A>C	ENST00000288135.5	+	5	876	c.779A>C	c.(778-780)aAt>aCt	p.N260T		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	260	Ig-like C2-type 3.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAGAAATATAATAGCTGGCAT	0.343000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				12	211					0	0	0.457914	0	0
NRXN1	9378	broad.mit.edu	37	2	50699499	50699499	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:50699499G>A	ENST00000404971.1	-	17	4640	c.3301C>T	c.(3301-3303)Cgg>Tgg	p.R1101W	NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401710.1_Missense_Mutation_p.R70W|NRXN1_ENST00000402717.3_Missense_Mutation_p.R1053W|NRXN1_ENST00000405472.3_Missense_Mutation_p.R1053W|NRXN1_ENST00000401669.2_Missense_Mutation_p.R1061W|NRXN1_ENST00000406316.2_Missense_Mutation_p.R1061W|NRXN1_ENST00000406859.3_Missense_Mutation_p.R1061W	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1061	EGF-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.R1102W(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCGGAAGCCGTCCATTTAAA	0.413000													9	12					0	0	0.361761	0	0
PLP2	5355	broad.mit.edu	37	X	49030730	49030730	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:49030730A>T	ENST00000376327.5	+	4	469	c.394A>T	c.(394-396)Acc>Tcc	p.T132S		NM_002668.2	NP_002659.1	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic epithelium-enriched)	132	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity			endometrium(3)|large_intestine(1)|lung(6)|urinary_tract(3)	13						TGCCTATGTCACCTTCCCCGT	0.562000													58	66					0	0	0.870114	0	0
OBSCN	84033	broad.mit.edu	37	1	228482036	228482036	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:228482036G>T	ENST00000570156.2	+	47	12676	c.12602G>T	c.(12601-12603)cGt>cTt	p.R4201L	OBSCN_ENST00000366709.4_Missense_Mutation_p.R891L|OBSCN_ENST00000366707.4_Missense_Mutation_p.R891L|OBSCN_ENST00000422127.1_Missense_Mutation_p.R3772L|OBSCN_ENST00000284548.11_Missense_Mutation_p.R3772L|OBSCN_ENST00000359599.6_Missense_Mutation_p.R2619L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3244	Ig-like 43.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGCAGATCCGTGGCCTGGCT	0.622000													51	202					4.48484e-38	9.56969e-38	0.870114	1	0
SUSD1	64420	broad.mit.edu	37	9	114875150	114875150	+	Splice_Site	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:114875150T>C	ENST00000374270.3	-	7	1059		c.e7-2		SUSD1_ENST00000374263.3_Splice_Site|SUSD1_ENST00000374264.2_Splice_Site	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1							integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TCAGAATTTCTAAAAGAGAAA	0.373000													6	16					0	0	0.278610	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223873	142223873	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142223873G>T	ENST00000390367.3	-	0	310																											CTGCAGGCTGGATCTTGAGAG	0.502000													28	138					2.38352e-08	3.07878e-08	0.796494	1	0
TENM1	10178	broad.mit.edu	37	X	123637453	123637453	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123637453T>A	ENST00000422452.2	-	19	3465	c.3402A>T	c.(3400-3402)ggA>ggT	p.G1134G	TENM1_ENST00000371130.3_Silent_p.G1134G	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AAGACCAGCCTCCTAGGTTAG	0.363000													28	137					0	0	0.750413	0	0
TNR	7143	broad.mit.edu	37	1	175335275	175335275	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:175335275C>G	ENST00000367674.1	-	11	2762		c.e11-1		TNR_ENST00000263525.2_Splice_Site	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R						axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTGTCAAGTTCTGTGGATTGA	0.522000													6	33					0	0	0.278610	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187692887	187692887	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:187692887C>A	ENST00000295131.2	-	9	1765	c.1726G>T	c.(1726-1728)Gat>Tat	p.D576Y		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	576					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AGATTGAAATCCTCTGGAAGT	0.373000													25	39					2.65835e-16	4.37708e-16	0.717897	1	0
BRSK1	84446	broad.mit.edu	37	19	55816283	55816283	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55816283T>A	ENST00000309383.1	+	14	1989	c.1712T>A	c.(1711-1713)aTg>aAg	p.M571K	BRSK1_ENST00000326848.7_Missense_Mutation_p.M266K|BRSK1_ENST00000590333.1_Missense_Mutation_p.M587K|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	571					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CGGCGCAAGATGCAGGGTATG	0.627000													49	21					0	0	0.870114	0	0
VPS13A	23230	broad.mit.edu	37	9	79966273	79966273	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:79966273G>A	ENST00000360280.3	+	53	7590	c.7330G>A	c.(7330-7332)Gcc>Acc	p.A2444T	VPS13A_ENST00000376636.3_Missense_Mutation_p.A2405T|VPS13A_ENST00000376634.4_Missense_Mutation_p.A2444T|VPS13A_ENST00000357409.5_Missense_Mutation_p.A2444T	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2444					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TCCTGGTAAAGCCGTGTTTTA	0.413000													52	74					0	0	0.870114	0	0
SELT	51714	broad.mit.edu	37	3	150342671	150342671	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:150342671G>C	ENST00000471696.1	+	4	523	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	SELT_ENST00000485923.1_Missense_Mutation_p.E92Q|SELT_ENST00000477889.1_Missense_Mutation_p.E92Q|SELT_ENST00000480740.1_Missense_Mutation_p.E92Q	NM_016275.3	NP_057359.2	P62341	SELT_HUMAN		150					cell redox homeostasis|selenocysteine incorporation		selenium binding							LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGGTGCATTTGAGATAACTTT	0.279000													4	6					0	0	0.217242	0	0
TMEM2	23670	broad.mit.edu	37	9	74305070	74305070	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:74305070C>A	ENST00000377044.4	-	22	4328	c.3789G>T	c.(3787-3789)acG>acT	p.T1263T	TMEM2_ENST00000396272.3_Silent_p.T256T|TMEM2_ENST00000377066.5_Silent_p.T1200T	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	1263						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GAGGAAAAACCGTTTTTTCCG	0.488000													27	74					1.61788e-16	2.67561e-16	0.760397	1	0
MYBPC1	4604	broad.mit.edu	37	12	102046992	102046992	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:102046992C>A	ENST00000549145.1	+	17	1797	c.1697C>A	c.(1696-1698)cCa>cAa	p.P566Q	RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000545503.2_Missense_Mutation_p.P553Q|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000536007.1_Missense_Mutation_p.P534Q|MYBPC1_ENST00000360610.2_Missense_Mutation_p.P553Q|MYBPC1_ENST00000547509.1_Missense_Mutation_p.P539Q|MYBPC1_ENST00000541119.1_Missense_Mutation_p.P541Q|MYBPC1_ENST00000553190.1_Missense_Mutation_p.P553Q|MYBPC1_ENST00000452455.2_Missense_Mutation_p.P553Q|MYBPC1_ENST00000441232.1_Missense_Mutation_p.P553Q|MYBPC1_ENST00000392934.3_Missense_Mutation_p.P540Q|MYBPC1_ENST00000551300.1_Missense_Mutation_p.P454Q|MYBPC1_ENST00000361685.2_Missense_Mutation_p.P578Q|MYBPC1_ENST00000361466.2_Missense_Mutation_p.P578Q|MYBPC1_ENST00000547405.1_Missense_Mutation_p.P527Q|MYBPC1_ENST00000550270.1_Missense_Mutation_p.P553Q			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	553	Ig-like C2-type 5.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AGCGGAGAACCACCTCCTAAA	0.502000													19	43					1.96292e-10	2.74459e-10	0.592651	1	0
SLC4A8	9498	broad.mit.edu	37	12	51851217	51851217	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:51851217G>C	ENST00000453097.2	+	6	874	c.657G>C	c.(655-657)aaG>aaC	p.K219N	SLC4A8_ENST00000394856.1_Missense_Mutation_p.K166N|SLC4A8_ENST00000358657.3_Missense_Mutation_p.K246N|SLC4A8_ENST00000535225.2_Missense_Mutation_p.K166N|SLC4A8_ENST00000514353.3_Missense_Mutation_p.K166N	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	219					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTCTCAAAAAGCATCATCATC	0.463000													15	43					0	0	0.479597	0	0
TG	7038	broad.mit.edu	37	8	133906138	133906138	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:133906138G>T	ENST00000220616.4	+	11	3005	c.2965G>T	c.(2965-2967)Ggg>Tgg	p.G989W	TG_ENST00000377869.1_Missense_Mutation_p.G989W	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	989	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTCTGCGTGGGAGTGATTA	0.577000													9	73					0.0477658	0.0489092	0.307466	1	0
MAP4K4	9448	broad.mit.edu	37	2	102493590	102493590	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:102493590G>A	ENST00000413150.2	+	23	2732	c.2677G>A	c.(2677-2679)Gtc>Atc	p.V893I	MAP4K4_ENST00000456652.1_Missense_Mutation_p.V777I|MAP4K4_ENST00000324219.4_Missense_Mutation_p.V1059I|MAP4K4_ENST00000350198.4_Missense_Mutation_p.V897I|MAP4K4_ENST00000350878.4_Missense_Mutation_p.V1018I|MAP4K4_ENST00000347699.4_Missense_Mutation_p.V978I|MAP4K4_ENST00000302217.5_Missense_Mutation_p.V781I|MAP4K4_ENST00000425019.1_Missense_Mutation_p.V1011I	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	978	Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GGGCTTGAATGTCTTGGTGAC	0.423000													13	44					0	0	0.557998	0	0
CNTN3	5067	broad.mit.edu	37	3	74334466	74334466	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:74334466G>A	ENST00000263665.6	-	19	2721	c.2694C>T	c.(2692-2694)acC>acT	p.T898T		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	898	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GCGTTTTCTTGGTGGTTACAT	0.453000													43	63					0	0	0.870114	0	0
RGPD4	285190	broad.mit.edu	37	2	108499191	108499191	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:108499191G>A	ENST00000408999.3	+	22	5205	c.5128G>A	c.(5128-5130)Gtg>Atg	p.V1710M	RGPD4_ENST00000354986.4_Missense_Mutation_p.V1710M	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1710	GRIP.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TGCAGCTAACGTGGAACACTT	0.408000													32	70					0	0	0.859065	0	0
HERC2	8924	broad.mit.edu	37	15	28513632	28513632	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:28513632C>A	ENST00000261609.7	-	12	1685	c.1577G>T	c.(1576-1578)cGg>cTg	p.R526L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	526					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGGCCCAGCCGTCCGCCGTC	0.522000													23	27					7.26314e-15	1.15061e-14	0.717897	1	0
AP1G2	8906	broad.mit.edu	37	14	24028973	24028973	+	Silent	SNP	C	C	T	rs141400350	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:24028973C>T	ENST00000308724.5	-	21	3098	c.2343G>A	c.(2341-2343)gtG>gtA	p.V781V	THTPA_ENST00000288014.6_3'UTR|AP1G2_ENST00000397120.3_Silent_p.V781V|RP11-66N24.4_ENST00000553985.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	781					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GCCACGATTCCACAGGCAAGT	0.572000											OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	42					0	0	0.248553	0	0
PRDM9	56979	broad.mit.edu	37	5	23521206	23521206	+	Silent	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:23521206A>C	ENST00000296682.3	+	6	608	c.426A>C	c.(424-426)gcA>gcC	p.A142A		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	142					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TACTGAATGCAAGTGGCTCAG	0.408000										HNSCC(3;0.000094)			8	52					0	0	0.335167	0	0
MYO1A	4640	broad.mit.edu	37	12	57423577	57423577	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:57423577C>G	ENST00000442789.2	-	26	2958	c.2671G>C	c.(2671-2673)Ggg>Cgg	p.G891R	MYO1A_ENST00000544473.1_Missense_Mutation_p.G729R|MYO1A_ENST00000300119.3_Missense_Mutation_p.G891R	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	891					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AGAACAGGCCCCTCCTCCCCG	0.577000													51	71					0	0	0.870114	0	0
SMG1	23049	broad.mit.edu	37	16	18896878	18896878	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:18896878G>A	ENST00000446231.2	-	7	1345	c.933C>T	c.(931-933)ttC>ttT	p.F311F	SMG1_ENST00000389467.3_Silent_p.F311F|SMG1_ENST00000565224.1_Silent_p.F285F			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	311	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AATTAGTGCTGAAAATATGAG	0.428000													18	84					0	0	0.608945	0	0
PRRC2C	23215	broad.mit.edu	37	1	171509779	171509779	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:171509779G>T	ENST00000367742.3	+	16	3416	c.3174G>T	c.(3172-3174)aaG>aaT	p.K1058N	PRRC2C_ENST00000426496.2_Missense_Mutation_p.K1056N|PRRC2C_ENST00000392078.3_Missense_Mutation_p.K1058N|PRRC2C_ENST00000338920.4_Missense_Mutation_p.K1056N			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1056							protein C-terminus binding										CGGAAAAGAAGGATCTTCCTC	0.468000													14	81					1.33834e-09	1.81205e-09	0.557998	1	0
ABCA7	10347	broad.mit.edu	37	19	1041907	1041907	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:1041907A>G	ENST00000263094.6	+	4	469	c.238A>G	c.(238-240)Acc>Gcc	p.T80A	ABCA7_ENST00000433129.1_Missense_Mutation_p.T80A	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	80					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGAACAACACCTGCTTTCC	0.652000													6	8					0	0	0.248553	0	0
MAGI2	9863	broad.mit.edu	37	7	79082573	79082573	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:79082573T>A	ENST00000354212.4	-	1	317	c.64A>T	c.(64-66)Agg>Tgg	p.R22W	MAGI2_ENST00000522391.1_Missense_Mutation_p.R22W|MAGI2-AS3_ENST00000426835.1_RNA|MAGI2_ENST00000419488.1_Missense_Mutation_p.R22W|MAGI2-AS3_ENST00000446159.1_RNA|MAGI2-AS3_ENST00000429408.1_RNA	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	22	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCCGGGTTCCTGCCAATGACA	0.582000													13	210					0	0	0.539581	0	0
TMEM196	256130	broad.mit.edu	37	7	19765326	19765326	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19765326G>A	ENST00000405844.1	-	3	965	c.270C>T	c.(268-270)ctC>ctT	p.L90L	TMEM196_ENST00000493519.1_Silent_p.L22L|TMEM196_ENST00000433641.1_Silent_p.L22L|TMEM196_ENST00000422233.1_Silent_p.L22L|TMEM196_ENST00000405764.3_Silent_p.L90L			Q5HYL7	TM196_HUMAN	transmembrane protein 196	96						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						TGACTGCCCGGAGGAACTGAA	0.498000													13	102					0	0	0.539581	0	0
PREX1	57580	broad.mit.edu	37	20	47248856	47248856	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:47248856C>G	ENST00000396220.1	-	34	4611	c.4589G>C	c.(4588-4590)cGc>cCc	p.R1530P	PREX1_ENST00000371941.3_Silent_p.A1495A			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCAGGGACTGCGCGTTGATGT	0.642000													119	199					0	0	0.870114	0	0
LRGUK	136332	broad.mit.edu	37	7	133859350	133859350	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:133859350A>C	ENST00000285928.2	+	8	1051	c.982A>C	c.(982-984)Atc>Ctc	p.I328L		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	328							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						AAATTTACCCATCCTTCGAGT	0.353000													16	70					0	0	0.557998	0	0
AOC3	8639	broad.mit.edu	37	17	41003387	41003387	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:41003387C>A	ENST00000308423.2	+	1	187	c.27C>A	c.(25-27)ctC>ctA	p.L9L		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	9					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TCCTCGTGCTCCTCATTCTGG	0.557000													78	137					2.34042e-70	5.29407e-70	0.870114	1	0
CACNG5	27091	broad.mit.edu	37	17	64881120	64881120	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:64881120G>T	ENST00000533854.1	+	6	828	c.591G>T	c.(589-591)gtG>gtT	p.V197V	CACNG5_ENST00000307139.3_Silent_p.V197V			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	197				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TGATGTCTGTGTACCTGTTTA	0.612000													52	20					9.53978e-28	1.88988e-27	0.870114	1	0
FAT3	120114	broad.mit.edu	37	11	92087069	92087069	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:92087069C>G	ENST00000298047.6	+	1	1808	c.1791C>G	c.(1789-1791)atC>atG	p.I597M	FAT3_ENST00000409404.2_Missense_Mutation_p.I597M|FAT3_ENST00000541502.1_Missense_Mutation_p.I597M|FAT3_ENST00000525166.1_Missense_Mutation_p.I447M			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	597	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGTCACATCACAGCAGTCT	0.393000										TCGA Ovarian(4;0.039)			4	19					0	0	0.150653	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147622	118147622	+	Missense_Mutation	SNP	C	C	T	rs145638764		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:118147622C>T	ENST00000456015.2	+	1	56	c.56C>T	c.(55-57)gCt>gTt	p.A19V	SLC30A8_ENST00000519688.1_5'UTR|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000427715.2_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	19					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AAGATGTATGCTTTCACACTA	0.413000													20	158					0	0	0.681144	0	0
MUC16	94025	broad.mit.edu	37	19	9026256	9026256	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:9026256C>A	ENST00000397910.4	-	14	36933	c.36730G>T	c.(36730-36732)Gag>Tag	p.E12244*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12246	SEA 2.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E12244*(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGTCCTCCTCGTACTGCAGG	0.532000													83	176					4.21773e-46	9.29482e-46	0.870114	1	0
CRLF1	9244	broad.mit.edu	37	19	18709363	18709363	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:18709363G>T	ENST00000392386.3	-	4	769	c.576C>A	c.(574-576)ccC>ccA	p.P192P		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	192	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						GGCAGGAGTGGGGCCCCACTG	0.632000													72	78					1.46619e-26	2.86539e-26	0.870114	1	0
CUBN	8029	broad.mit.edu	37	10	16941027	16941027	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:16941027C>T	ENST00000377833.4	-	54	8631	c.8566G>A	c.(8566-8568)Ggt>Agt	p.G2856S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2856	CUB 21.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTCCATCACCGCTGGGGATT	0.403000													14	93					0	0	0.539581	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656320	40656320	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:40656320T>A	ENST00000406785.1	-	2	1290	c.1101A>T	c.(1099-1101)caA>caT	p.Q367H	SLC8A1_ENST00000542756.1_Missense_Mutation_p.Q367H|SLC8A1_ENST00000542024.1_Missense_Mutation_p.Q367H|SLC8A1_ENST00000408028.2_Missense_Mutation_p.Q367H|SLC8A1_ENST00000406391.2_Missense_Mutation_p.Q367H|SLC8A1_ENST00000405901.3_Missense_Mutation_p.Q367H|SLC8A1_ENST00000405269.1_Missense_Mutation_p.Q367H|SLC8A1_ENST00000403092.1_Missense_Mutation_p.Q367H|SLC8A1_ENST00000402441.1_Missense_Mutation_p.Q367H|SLC8A1_ENST00000332839.4_Missense_Mutation_p.Q367H			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	367					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GGCGAGTAGCTTGAATGCGAT	0.433000													33	63					0	0	0.812448	0	0
HSF2BP	11077	broad.mit.edu	37	21	45012209	45012209	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:45012209C>A	ENST00000291560.2	-	8	1024	c.692_splice	c.e8-1	p.V231_splice	HSF2BP_ENST00000542962.1_Splice_Site_p.V156_splice	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	231					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		TCAGCATTAGCCTGAAATGTA	0.393000													19	21					1.28384e-07	1.60437e-07	0.608945	1	0
PROS1	5627	broad.mit.edu	37	3	93629474	93629474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:93629474C>A	ENST00000394236.3	-	4	651	c.335G>T	c.(334-336)aGc>aTc	p.S112I	PROS1_ENST00000407433.1_5'UTR	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	112	Thrombin-sensitive.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ATTGACACAGCTTCTTAGGTC	0.338000													57	30					3.98911e-17	6.72113e-17	0.870114	1	0
EDNRB	1910	broad.mit.edu	37	13	78475251	78475251	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:78475251C>A	ENST00000377211.4	-	5	1315	c.1163G>T	c.(1162-1164)tGt>tTt	p.C388F	EDNRB_ENST00000334286.5_Missense_Mutation_p.C298F|EDNRB_ENST00000446573.1_Missense_Mutation_p.C298F	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	298					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CAACATTTCACAGGTCATTAG	0.343000													17	100					1.67942e-08	2.1858e-08	0.539581	1	0
MAGEB10	139422	broad.mit.edu	37	X	27839903	27839903	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:27839903G>T	ENST00000356790.2	+	3	725	c.480G>T	c.(478-480)ctG>ctT	p.L160L		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	160	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CTGAGCACCTGGAGCTGATCT	0.453000													14	29					1.5739e-10	2.22045e-10	0.500413	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5146311	5146311	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:5146311C>G	ENST00000274181.7	+	3	382	c.244C>G	c.(244-246)Cat>Gat	p.H82D	CTD-2297D10.1_ENST00000514848.1_RNA|ADAMTS16_ENST00000511368.1_Missense_Mutation_p.H82D	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	82					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AATCATGCACCATCAGCGGCG	0.542000													16	137					0	0	0.520397	0	0
FLT3	2322	broad.mit.edu	37	13	28588651	28588651	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:28588651G>T	ENST00000380982.4	-	23	2887	c.2806C>A	c.(2806-2808)Cgg>Agg	p.R936R	FLT3_ENST00000537084.1_Silent_p.R892R|FLT3_ENST00000241453.7_Silent_p.R933R			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	933	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAGGATGGCCGTTTCCTTGAG	0.408000			"""Mis, O"""		"""AML, ALL"""								6	49					8.12818e-05	9.07848e-05	0.248553	1	0
NTNG2	84628	broad.mit.edu	37	9	135073442	135073442	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:135073442G>A	ENST00000393229.3	+	3	1079	c.303G>A	c.(301-303)gaG>gaA	p.E101E	NTNG2_ENST00000372179.3_Silent_p.E101E|NTNG2_ENST00000393228.4_Silent_p.E101E|NTNG2_ENST00000360670.3_Silent_p.E101E	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	101	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		AGGAGGAGGAGGGCCTGGCCA	0.642000													34	39					0	0	0.812448	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737845	62737845	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:62737845C>A	ENST00000369768.1	-	1	679	c.340G>T	c.(340-342)Gag>Tag	p.E114*		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	114						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CAGAGCAGCTCCCCGAAGGGC	0.607000													25	38					1.75199e-13	2.69823e-13	0.717897	1	0
DCT	1638	broad.mit.edu	37	13	95121177	95121177	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:95121177G>T	ENST00000377028.5	-	2	831	c.418C>A	c.(418-420)Cag>Aag	p.Q140K	DCT_ENST00000446125.1_Missense_Mutation_p.Q140K	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	140					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		CCCAAGAACTGCTCTCTTTCC	0.557000													40	649					5.34276e-22	9.90647e-22	0.870114	1	0
RGS6	9628	broad.mit.edu	37	14	72943468	72943468	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:72943468G>T	ENST00000553530.1	+	11	919	c.712G>T	c.(712-714)Gaa>Taa	p.E238*	RGS6_ENST00000553525.1_Nonsense_Mutation_p.E238*|RGS6_ENST00000402788.2_Nonsense_Mutation_p.E238*|RGS6_ENST00000343854.6_Nonsense_Mutation_p.E238*|RGS6_ENST00000554782.1_Nonsense_Mutation_p.E99*|RGS6_ENST00000404301.2_Nonsense_Mutation_p.E238*|RGS6_ENST00000555571.1_Nonsense_Mutation_p.E238*|RGS6_ENST00000355512.6_Nonsense_Mutation_p.E238*|RGS6_ENST00000556437.1_Nonsense_Mutation_p.E238*|RGS6_ENST00000406236.4_Nonsense_Mutation_p.E238*|RGS6_ENST00000434263.2_Nonsense_Mutation_p.E169*|RGS6_ENST00000407322.4_Nonsense_Mutation_p.E238*	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	238					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TGGCGTGACTGAAGAGTCCCA	0.507000													24	49					2.48779e-11	3.60156e-11	0.693898	1	0
TUBE1	51175	broad.mit.edu	37	6	112397166	112397166	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:112397166C>A	ENST00000368662.5	-	8	864	c.786G>T	c.(784-786)gtG>gtT	p.V262V	TUBE1_ENST00000604814.1_5'UTR	NM_016262.4	NP_057346.1	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	262					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	12		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		GCAAATTTGCCACAATGTTAT	0.368000													17	21					1.67942e-08	2.1858e-08	0.539581	1	0
MARK2	2011	broad.mit.edu	37	11	63668340	63668340	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:63668340C>T	ENST00000402010.2	+	10	1556	c.977C>T	c.(976-978)cCc>cTc	p.P326L	MARK2_ENST00000513765.2_Missense_Mutation_p.P293L|MARK2_ENST00000508192.1_Missense_Mutation_p.P326L|MARK2_ENST00000377809.4_Missense_Mutation_p.P326L|MARK2_ENST00000408948.3_Missense_Mutation_p.P293L|MARK2_ENST00000315032.8_Missense_Mutation_p.P326L|MARK2_ENST00000413835.2_Missense_Mutation_p.P326L|MARK2_ENST00000502399.3_Missense_Mutation_p.P326L|MARK2_ENST00000377810.3_Missense_Mutation_p.P293L|MARK2_ENST00000509502.2_Missense_Mutation_p.P293L|MARK2_ENST00000425897.2_Missense_Mutation_p.P293L|MARK2_ENST00000361128.5_Missense_Mutation_p.P326L|MARK2_ENST00000350490.7_Missense_Mutation_p.P326L	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	326	UBA.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						TACAAGGACCCCCGGCGGACA	0.542000													46	85					0	0	0.870114	0	0
APOA5	116519	broad.mit.edu	37	11	116661500	116661500	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:116661500C>T	ENST00000542499.1	-	4	517	c.445G>A	c.(445-447)Gag>Aag	p.E149K	APOA5_ENST00000227665.4_Missense_Mutation_p.E149K	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	149					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		CGCAACTGCTCCTGCAGCTCC	0.652000													29	72					0	0	0.769981	0	0
MFAP1	4236	broad.mit.edu	37	15	44116690	44116690	+	Splice_Site	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:44116690T>A	ENST00000267812.3	-	1	310	c.79_splice	c.e1+1	p.K26_splice		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	26						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		GCACCGTACCTTTCTCATTGC	0.592000													18	74					0	0	0.624587	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738827	176738827	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:176738827T>A	ENST00000367662.3	+	16	5572	c.4408T>A	c.(4408-4410)Tct>Act	p.S1470T		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1470	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCCCGACCCGTCTTTGGTGAA	0.498000													19	128					0	0	0.639603	0	0
ZNF611	81856	broad.mit.edu	37	19	53209778	53209778	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:53209778C>A	ENST00000543227.1	-	6	804	c.530G>T	c.(529-531)gGt>gTt	p.G177V	ZNF611_ENST00000602162.1_Missense_Mutation_p.G108V|ZNF611_ENST00000595798.1_Missense_Mutation_p.G108V|ZNF611_ENST00000540744.1_Missense_Mutation_p.G177V|ZNF611_ENST00000453741.2_Missense_Mutation_p.G108V|ZNF611_ENST00000319783.1_Missense_Mutation_p.G177V	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		AAGTTGATTACCAATTTCACC	0.393000													43	53					6.14515e-18	1.05522e-17	0.870114	1	0
MAP7D1	55700	broad.mit.edu	37	1	36644085	36644085	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:36644085G>T	ENST00000316156.4	+	9	2116	c.1663G>T	c.(1663-1665)Ggc>Tgc	p.G555C	MAP7D1_ENST00000373151.2_Missense_Mutation_p.G592C|MAP7D1_ENST00000373148.4_Missense_Mutation_p.G129C|MAP7D1_ENST00000373150.4_Missense_Mutation_p.G560C			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	592	Pro-rich.					cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				ACCAATGGCCGGCACCACAGA	0.692000													13	20					6.31663e-08	8.01611e-08	0.479597	1	0
TTC18	118491	broad.mit.edu	37	10	75104936	75104936	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:75104936C>T	ENST00000401621.2	-	6	616	c.496G>A	c.(496-498)Ggc>Agc	p.G166S	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.G166S|TTC18_ENST00000310715.3_Missense_Mutation_p.G166S|TTC18_ENST00000340329.3_Missense_Mutation_p.G166S			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	166							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					AGTAGATTGCCCCCTGAGATC	0.463000													18	46					0	0	0.608945	0	0
AVPR2	554	broad.mit.edu	37	X	153171744	153171744	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153171744G>T	ENST00000358927.2	+	3	993	c.784G>T	c.(784-786)Gtg>Ttg	p.V262L	AVPR2_ENST00000370049.1_Missense_Mutation_p.V262L|AVPR2_ENST00000337474.5_Missense_Mutation_p.V262L			P30518	V2R_HUMAN	arginine vasopressin receptor 2	262					activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	26	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	GGGAGCCCACGTGTCAGCAGC	0.657000													16	77					1.5739e-10	2.22045e-10	0.500413	1	0
CUL1	8454	broad.mit.edu	37	7	148454127	148454127	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:148454127G>T	ENST00000325222.4	+	4	647	c.368G>T	c.(367-369)tGg>tTg	p.W123L	CUL1_ENST00000409469.1_Missense_Mutation_p.W123L|CUL1_ENST00000602748.1_Missense_Mutation_p.W123L	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	123					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACTCAACAATGGGAAGATTAT	0.368000													41	76					9.84934e-19	1.71793e-18	0.853193	1	0
LIMS2	55679	broad.mit.edu	37	2	128399715	128399715	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:128399715T>A	ENST00000409455.1	-	6	1189	c.554A>T	c.(553-555)cAt>cTt	p.H185L	LIMS2_ENST00000410011.1_Missense_Mutation_p.H185L|LIMS2_ENST00000409808.2_Missense_Mutation_p.H185L|LIMS2_ENST00000409286.1_Missense_Mutation_p.H38L|LIMS2_ENST00000324938.5_Missense_Mutation_p.H214L|LIMS2_ENST00000409254.1_Missense_Mutation_p.H38L|LIMS2_ENST00000545738.2_Missense_Mutation_p.H212L|LIMS2_ENST00000355119.4_Missense_Mutation_p.H190L|LIMS2_ENST00000409754.1_Missense_Mutation_p.H38L|LIMS2_ENST00000410038.1_Missense_Mutation_p.H38L			Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	190	LIM zinc-binding 3.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CATCTTGTCATGGCAGGGCAG	0.692000													3	8					0	0	0.115264	0	0
GART	2618	broad.mit.edu	37	21	34876758	34876758	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:34876758G>A	ENST00000381831.3	-	21	3065	c.2802C>T	c.(2800-2802)acC>acT	p.T934T	GART_ENST00000381815.4_Silent_p.T934T|GART_ENST00000543717.1_Silent_p.T486T|GART_ENST00000381839.3_Silent_p.T934T	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	934	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	CTGTGACTCCGGTTTCCAGGG	0.403000													11	124					0	0	0.435327	0	0
UMODL1	89766	broad.mit.edu	37	21	43533708	43533708	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:43533708G>T	ENST00000400427.1	+	12	2694	c.2298G>T	c.(2296-2298)atG>atT	p.M766I	UMODL1_ENST00000408989.2_Missense_Mutation_p.M838I|UMODL1_ENST00000400424.1_Missense_Mutation_p.M638I|UMODL1_ENST00000408910.2_Missense_Mutation_p.M710I	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	746	Fibronectin type-III 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GGAGGATCATGGTCTCCAATG	0.512000													10	42					5.50884e-06	6.43952e-06	0.411799	1	0
RBM25	58517	broad.mit.edu	37	14	73572596	73572596	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:73572596G>T	ENST00000261973.7	+	11	1469	c.1184G>T	c.(1183-1185)cGa>cTa	p.R395L	RBM25_ENST00000527432.1_Missense_Mutation_p.R395L	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	395	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		GAAAGGGAACgagagcgggaa	0.448000													3	13					0.115264	0.117385	0.115264	1	0
PRELP	5549	broad.mit.edu	37	1	203452763	203452763	+	Missense_Mutation	SNP	G	G	T	rs145563455	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:203452763G>T	ENST00000343110.2	+	2	578	c.451G>T	c.(451-453)Ggc>Tgc	p.G151C		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	151					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAACTGCCCGGCCTGGTGTT	0.592000													22	203					3.6726e-16	6.02076e-16	0.667858	1	0
SLC9C2	284525	broad.mit.edu	37	1	173569328	173569328	+	Nonsense_Mutation	SNP	A	A	T	rs146497382	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:173569328A>T	ENST00000367714.3	-	3	578	c.156T>A	c.(154-156)tgT>tgA	p.C52*	RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Intron	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	52					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										CAATGACTTCACAATTCTTTA	0.348000													17	43					0	0	0.557998	0	0
CEP164	22897	broad.mit.edu	37	11	117280536	117280536	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:117280536C>T	ENST00000278935.3	+	30	4098	c.3951C>T	c.(3949-3951)tcC>tcT	p.S1317S	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1317					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		ACTATGGCTCCCTGGCCAGGT	0.667000													31	181					0	0	0.796494	0	0
CLCA4	22802	broad.mit.edu	37	1	87045786	87045786	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:87045786C>A	ENST00000370563.3	+	14	2560	c.2518C>A	c.(2518-2520)Cac>Aac	p.H840N	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	840						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AAATGCAACCCACATATTTAT	0.348000													13	47					2.32078e-09	3.13323e-09	0.479597	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655201	31655201	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:31655201G>C	ENST00000340345.4	-	1	75	c.50C>G	c.(49-51)aCc>aGc	p.T17S		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	17						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						GTATGATGTGGTACTGCAGAC	0.493000													13	24					0	0	0.500413	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829854	106829854	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:106829854G>T	ENST00000390616.2	-	0	139																											GGCTTCAACAGTCCTGCGCCC	0.597000													29	32					3.03874e-20	5.4884e-20	0.779181	1	0
ZNF280A	129025	broad.mit.edu	37	22	22869518	22869518	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:22869518T>A	ENST00000302097.3	-	2	689	c.437A>T	c.(436-438)cAg>cTg	p.Q146L		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AACTAGACACTGAGTCCCTGG	0.448000													16	25					0	0	0.750413	0	0
EBF1	1879	broad.mit.edu	37	5	158140043	158140043	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:158140043C>G	ENST00000313708.6	-	13	1586	c.1304G>C	c.(1303-1305)gGc>gCc	p.G435A	EBF1_ENST00000380654.4_Missense_Mutation_p.G404A|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Missense_Mutation_p.G427A	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	435					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGAATTCACGCCCATCATCCC	0.577000			T	HMGA2	lipoma								31	45					0	0	0.796494	0	0
CACNA1F	778	broad.mit.edu	37	X	49077499	49077499	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:49077499C>A	ENST00000376265.2	-	18	2423	c.2362G>T	c.(2362-2364)Ggc>Tgc	p.G788C	CACNA1F_ENST00000323022.5_Missense_Mutation_p.G777C|CACNA1F_ENST00000376251.1_Missense_Mutation_p.G723C	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	788					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CTCACCAGGCCTTCATTCTCC	0.483000													24	36					7.11191e-15	1.1295e-14	0.769981	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130343026	130343026	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:130343026G>T	ENST00000299164.2	+	8	2163	c.2163G>T	c.(2161-2163)ggG>ggT	p.G721G		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	721	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GGCTGATCGGGGATGACAACT	0.617000													17	86					4.14922e-12	6.15838e-12	0.500413	1	0
ADPRH	141	broad.mit.edu	37	3	119305482	119305482	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:119305482C>G	ENST00000478399.1	+	3	2054	c.649C>G	c.(649-651)Ctt>Gtt	p.L217V	ADPRH_ENST00000478927.1_Missense_Mutation_p.L217V|ADPRH_ENST00000465513.1_Missense_Mutation_p.L217V|ADPRH_ENST00000357003.3_Missense_Mutation_p.L217V|ADPRH_ENST00000471850.1_3'UTR			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	217					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AGAGGAAAATCTTCAACACTG	0.463000													44	128					0	0	0.870114	0	0
CTNND2	1501	broad.mit.edu	37	5	11346711	11346711	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:11346711G>T	ENST00000304623.8	-	9	1590	c.1401C>A	c.(1399-1401)gtC>gtA	p.V467V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Silent_p.V130V|CTNND2_ENST00000359640.2_Silent_p.V467V|CTNND2_ENST00000511377.1_Silent_p.V376V|CTNND2_ENST00000458100.2_Silent_p.V34V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	467					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCTGCAAGGGGACGGAGTCGA	0.607000													21	19					2.89027e-11	4.15863e-11	0.624587	1	0
CLTA	1211	broad.mit.edu	37	9	36197559	36197559	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:36197559G>T	ENST00000433436.2	+	2	430	c.229G>T	c.(229-231)Gga>Tga	p.G77*	CLTA_ENST00000538225.1_Nonsense_Mutation_p.G77*|CLTA_ENST00000466396.1_Intron|CLTA_ENST00000345519.5_Nonsense_Mutation_p.G77*|CLTA_ENST00000470744.1_Nonsense_Mutation_p.G77*|CLTA_ENST00000396603.2_Nonsense_Mutation_p.G77*|CLTA_ENST00000540080.1_Intron|CLTA_ENST00000242285.6_Nonsense_Mutation_p.G77*	NM_007096.3	NP_009027.1	P09496	CLCA_HUMAN	clathrin, light chain A	77					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol	structural molecule activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	6			STAD - Stomach adenocarcinoma(86;0.228)			TGCTGTTGATGGAGTAATGAA	0.393000													47	228					4.96213e-28	9.85099e-28	0.870114	1	0
HEPACAM	220296	broad.mit.edu	37	11	124793767	124793767	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:124793767A>T	ENST00000298251.4	-	3	972	c.567T>A	c.(565-567)aaT>aaA	p.N189K		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	189	Ig-like C2-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TTCTCGAGTCATTGAGGAGGG	0.582000													10	33					0	0	0.387290	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138656	101138656	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:101138656T>A	ENST00000372782.3	-	7	1790	c.1743A>T	c.(1741-1743)agA>agT	p.R581S	ZMAT1_ENST00000540921.1_Missense_Mutation_p.R581S|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000458570.1_Missense_Mutation_p.R410S	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	410						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						TATCCTCCTCTCTTTTCCTTT	0.403000													30	87					0	0	0.859065	0	0
CLK2	1196	broad.mit.edu	37	1	155238094	155238094	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:155238094C>A	ENST00000368361.4	-	5	859	c.544G>T	c.(544-546)Gac>Tac	p.D182Y	CLK2_ENST00000355560.4_Missense_Mutation_p.D180Y|CLK2_ENST00000536801.1_Missense_Mutation_p.D182Y|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000361168.5_Missense_Mutation_p.D181Y			P49760	CLK2_HUMAN	CDC-like kinase 2	182	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGCGATGGTCAACACATTGT	0.488000								Other conserved DNA damage response genes					33	46					2.53324e-40	5.44864e-40	0.840704	1	0
IGKV1-17	28937	broad.mit.edu	37	2	89416898	89416898	+	RNA	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:89416898T>A	ENST00000490686.1	-	0	312																											CTGCTGATTGTGAGAGTGAAT	0.498000													50	93					0	0	0.870114	0	0
ASTN2	23245	broad.mit.edu	37	9	120053748	120053748	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:120053748G>T	ENST00000313400.4	-	2	587	c.487C>A	c.(487-489)Cag>Aag	p.Q163K	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.Q163K|ASTN2_ENST00000373996.3_Missense_Mutation_p.Q163K			O75129	ASTN2_HUMAN	astrotactin 2	163						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						AGCCACTGCTGTCTCCAGTGC	0.637000													38	50					2.29192e-23	4.33071e-23	0.870114	1	0
C3orf67	200844	broad.mit.edu	37	3	58739589	58739589	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:58739589C>A	ENST00000295966.7	-	15	1989	c.1484_splice	c.e15-1	p.D496_splice	C3orf67_ENST00000482387.1_Splice_Site_p.D622_splice	NM_198463.2	NP_940865.1	Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	495										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TTTAACCAGTCCCTAAAAAGA	0.438000													16	20					5.03518e-11	7.21722e-11	0.557998	1	0
C17orf74	201243	broad.mit.edu	37	17	7329792	7329792	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:7329792C>T	ENST00000333870.3	+	3	556	c.482C>T	c.(481-483)cCa>cTa	p.P161L	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	161						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				TTCCGTAACCCACATCGCAGC	0.602000													16	75					0	0	0.520397	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82369326	82369326	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:82369326C>A	ENST00000509081.1	-	5	769	c.548G>T	c.(547-549)cGg>cTg	p.R183L	RASGEF1B_ENST00000264400.2_Missense_Mutation_p.R184L|RASGEF1B_ENST00000335927.7_Missense_Mutation_p.R142L			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	184					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						AACTGTGAGCCGATCTGTGGA	0.493000													31	105					3.62531e-18	6.25948e-18	0.796494	1	0
PNMT	5409	broad.mit.edu	37	17	37824839	37824839	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:37824839C>A	ENST00000269582.2	+	1	429	c.111C>A	c.(109-111)cgC>cgA	p.R37R	PNMT_ENST00000581428.1_Silent_p.R37R|PNMT_ENST00000394246.1_Intron	NM_002686.3	NP_002677.1	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	37					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			NS(1)|breast(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCTACCTCCGCAACAACTACG	0.736000													6	9					0.00307968	0.00327455	0.278610	1	0
CD248	57124	broad.mit.edu	37	11	66084197	66084197	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:66084197C>A	ENST00000311330.3	-	1	318	c.302G>T	c.(301-303)cGc>cTc	p.R101L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	101	C-type lectin.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CGTGAAGCCGCGCAGTGGGCG	0.726000													13	38					4.7546e-09	6.31933e-09	0.500413	1	0
TRIM51	84767	broad.mit.edu	37	11	55655604	55655604	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55655604C>A	ENST00000449290.2	+	4	696	c.604C>A	c.(604-606)Cga>Aga	p.R202R	TRIM51_ENST00000244891.3_Silent_p.R59R	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	202						intracellular	zinc ion binding										GGAAAGGCTGCGAAAGGAGGG	0.433000													19	60					6.44725e-10	8.87617e-10	0.624587	1	0
ATP10D	57205	broad.mit.edu	37	4	47560043	47560043	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:47560043C>G	ENST00000273859.3	+	12	2456	c.2187C>G	c.(2185-2187)gaC>gaG	p.D729E	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	729					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AGAGCCCAGACGAAGCGGCCT	0.562000													10	38					0	0	0.361761	0	0
C19orf40	91442	broad.mit.edu	37	19	33464458	33464458	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:33464458G>T	ENST00000588258.1	+	3	343	c.233G>T	c.(232-234)cGg>cTg	p.R78L	C19orf40_ENST00000590179.1_Intron|C19orf40_ENST00000590281.1_Missense_Mutation_p.R78L|C19orf40_ENST00000589646.1_5'UTR	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	78					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					AGGCTTGTTCGGGTTAGAAAT	0.502000								Direct reversal of damage					66	123					3.13743e-37	6.66438e-37	0.870114	1	0
PGM5	5239	broad.mit.edu	37	9	71098929	71098929	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:71098929G>T	ENST00000396396.1	+	9	1673	c.1444G>T	c.(1444-1446)Gtg>Ttg	p.V482L		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	482					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						TTTTGAATACGTGGACCCTGT	0.517000													38	87					1.61863e-15	2.61931e-15	0.870114	1	0
GPR50	9248	broad.mit.edu	37	X	150348940	150348940	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:150348940G>T	ENST00000218316.3	+	2	954	c.885G>T	c.(883-885)ggG>ggT	p.G295G		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	295					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TGATCTACGGGCTCCTCAATG	0.488000													80	114					6.14238e-36	1.29162e-35	0.870114	1	0
FAT1	2195	broad.mit.edu	37	4	187540189	187540189	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:187540189C>A	ENST00000441802.2	-	10	7760	c.7551G>T	c.(7549-7551)acG>acT	p.T2517T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2517	Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.T2520T(1)|p.T2517T(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AATCCCCATCCGTAGTTTTCA	0.408000										HNSCC(5;0.00058)			14	150					4.14922e-12	6.15838e-12	0.500413	1	0
NOTCH1	4851	broad.mit.edu	37	9	139396325	139396325	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:139396325G>C	ENST00000277541.6	-	30	5588	c.5513C>G	c.(5512-5514)aCa>aGa	p.T1838R		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1838					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGGTGGTCTGTCTGGTCGTC	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			3	50					0	0	0.150653	0	0
UGT3A1	133688	broad.mit.edu	37	5	35988627	35988627	+	Silent	SNP	G	G	T	rs150814543	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:35988627G>T	ENST00000274278.3	-	2	478	c.121C>A	c.(121-123)Cgg>Agg	p.R41R	UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000503189.1_Silent_p.R41R|UGT3A1_ENST00000507113.1_Intron|UGT3A1_ENST00000333811.4_5'UTR	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	41						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAGACACCCGGTCCAACAGT	0.378000													20	85					4.59853e-10	6.34489e-10	0.693898	1	0
OR4K13	390433	broad.mit.edu	37	14	20502335	20502335	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:20502335G>T	ENST00000315693.2	-	1	584	c.583C>A	c.(583-585)Cta>Ata	p.L195I		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGGAGCTGTAGGATGTAGGTG	0.473000													17	53					2.35188e-11	3.41005e-11	0.539581	1	0
FAT3	120114	broad.mit.edu	37	11	92523213	92523213	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:92523213G>T	ENST00000298047.6	+	7	4457	c.4440G>T	c.(4438-4440)ctG>ctT	p.L1480L	FAT3_ENST00000409404.2_Silent_p.L1480L|FAT3_ENST00000525166.1_Silent_p.L1330L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1480	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CGGAGATCCTGCAGATTGAAG	0.448000										TCGA Ovarian(4;0.039)			36	113					5.48756e-27	1.07916e-26	0.859065	1	0
DLGAP3	58512	broad.mit.edu	37	1	35370712	35370712	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:35370712C>A	ENST00000373347.1	-	3	541	c.273G>T	c.(271-273)agG>agT	p.R91S	DLGAP3_ENST00000235180.4_Missense_Mutation_p.R91S			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	91					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CAGGGTACATCCTGGGGAAGG	0.697000													3	2					2.56e-06	3.05318e-06	0.150653	1	0
KALRN	8997	broad.mit.edu	37	3	124438037	124438037	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:124438037G>T	ENST00000360013.3	+	60	8808	c.8681G>T	c.(8680-8682)aGg>aTg	p.R2894M	KALRN_ENST00000291478.4_Missense_Mutation_p.R1197M|KALRN_ENST00000428018.2_Missense_Mutation_p.R1165M	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2893	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AACGTATGCAGGGTGGATTTC	0.498000													25	17					3.73148e-12	5.55589e-12	0.717897	1	0
TRIML1	339976	broad.mit.edu	37	4	189060977	189060977	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:189060977G>T	ENST00000332517.3	+	1	405	c.265G>T	c.(265-267)Gag>Tag	p.E89*		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	89					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GCTGCAGAGCGAGGATGAGCA	0.662000													5	22					1.23904e-05	1.42622e-05	0.184627	1	0
CHRDL1	91851	broad.mit.edu	37	X	109964654	109964654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:109964654G>A	ENST00000218054.4	-	5	599	c.403C>T	c.(403-405)Cag>Tag	p.Q135*	CHRDL1_ENST00000372045.1_Nonsense_Mutation_p.Q129*|CHRDL1_ENST00000394797.4_Nonsense_Mutation_p.Q135*|CHRDL1_ENST00000444321.2_Nonsense_Mutation_p.Q135*|CHRDL1_ENST00000482160.1_Intron|CHRDL1_ENST00000434224.1_Intron|CHRDL1_ENST00000372042.1_Nonsense_Mutation_p.Q136*	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	129	VWFC 2.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TGCCGATTCTGAAAGAGCCCT	0.488000													42	245					0	0	0.870114	0	0
MTNR1A	4543	broad.mit.edu	37	4	187454987	187454987	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:187454987C>A	ENST00000307161.5	-	2	1110	c.909G>T	c.(907-909)agG>agT	p.R303S	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	303					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity	p.R303S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGTATTCCTTCCTGAAATTTT	0.473000													32	56					8.69298e-16	1.41524e-15	0.827153	1	0
LPPR3	79948	broad.mit.edu	37	19	814478	814478	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:814478C>T	ENST00000359894.2	-	6	934	c.871G>A	c.(871-873)Gtg>Atg	p.V291M	LPPR3_ENST00000520876.3_Missense_Mutation_p.V263M	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		263						integral to membrane	phosphatidate phosphatase activity										CCGGCATACACGTCCACAGGG	0.657000													7	29					0	0	0.335167	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365353	30365353	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:30365353C>G	ENST00000305596.3	-	4	419	c.244G>C	c.(244-246)Gag>Cag	p.E82Q	CD2BP2_ENST00000569466.1_Missense_Mutation_p.E82Q	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	82					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						ACACCCCCCTCGCTGGGGAGT	0.582000													48	97					0	0	0.870114	0	0
PHF3	23469	broad.mit.edu	37	6	64356431	64356431	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:64356431G>T	ENST00000262043.3	+	2	315		c.e2-1		PHF3_ENST00000393387.1_5'UTR|PHF3_ENST00000509330.1_Splice_Site			Q92576	PHF3_HUMAN	PHD finger protein 3						multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TCTTTCTATAGGGCTGAAAGA	0.299000													12	39					0.00010058	0.000112073	0.411799	1	0
COL1A2	1278	broad.mit.edu	37	7	94048810	94048810	+	Splice_Site	SNP	G	G	T	rs72658158		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:94048810G>T	ENST00000297268.6	+	34	2497	c.2025_splice	c.e34-1	p.G676_splice		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	676			G -> D (in OI3).|G -> V (in OI3 and OI4).|Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTGGTACTAGGGTGCTCCTGG	0.443000										HNSCC(75;0.22)			19	35					0.00278032	0.00296295	0.639603	1	0
KIRREL	55243	broad.mit.edu	37	1	158058245	158058245	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158058245G>C	ENST00000368172.1	+	4	450		c.e4+1		KIRREL_ENST00000368173.3_Splice_Site|KIRREL_ENST00000416935.2_Splice_Site|KIRREL_ENST00000392272.2_Splice_Site|KIRREL_ENST00000359209.6_Splice_Site|KIRREL_ENST00000360089.4_Splice_Site			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					CTCAAATATGGTAAGACTCTT	0.488000													19	86					0	0	0.624587	0	0
APRT	353	broad.mit.edu	37	16	88876515	88876515	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:88876515C>G	ENST00000378364.3	-	4	407	c.363G>C	c.(361-363)caG>caC	p.Q121H	APRT_ENST00000563655.1_Missense_Mutation_p.Q94H|APRT_ENST00000426324.2_Missense_Mutation_p.Q121H	NM_000485.2	NP_000476.1	P07741	APT_HUMAN	adenine phosphoribosyltransferase	121			Q -> R (in dbSNP:rs8191494).		purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding			cervix(1)|endometrium(1)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	CGACCACCCTCTGTCCTGGCT	0.612000													72	58					0	0	0.870114	0	0
SLC18A2	6571	broad.mit.edu	37	10	119027194	119027194	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:119027194C>A	ENST00000298472.5	+	13	1276	c.1133C>A	c.(1132-1134)gCa>gAa	p.A378E	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	378				A -> P (in Ref. 1; AAA59877).	neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	ATTCCATTTGCAAAAAACATT	0.368000													3	20					0.115264	0.117385	0.115264	1	0
PPP2R5C	5527	broad.mit.edu	37	14	102323077	102323077	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:102323077G>C	ENST00000422945.2	+	4	338	c.242G>C	c.(241-243)tGc>tCc	p.C81S	PPP2R5C_ENST00000328724.5_Missense_Mutation_p.C105S|PPP2R5C_ENST00000557095.1_Missense_Mutation_p.C50S|PPP2R5C_ENST00000334743.5_Missense_Mutation_p.C50S|PPP2R5C_ENST00000350249.3_Missense_Mutation_p.C50S|PPP2R5C_ENST00000445439.3_Missense_Mutation_p.C50S	NM_001161725.1	NP_001155197.1	Q13362	2A5G_HUMAN	protein phosphatase 2, regulatory subunit B', gamma	50					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CGTCAGTGTTGCGTCCTCTTT	0.383000													82	131					0	0	0.870114	0	0
ROR2	4920	broad.mit.edu	37	9	94488836	94488836	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:94488836T>C	ENST00000375708.3	-	8	1571	c.1373A>G	c.(1372-1374)aAc>aGc	p.N458S	ROR2_ENST00000375715.1_Missense_Mutation_p.N318S|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	458					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TTTGTGCTGGTTAATGAGGGG	0.517000													15	93					0	0	0.539581	0	0
TAF1	6872	broad.mit.edu	37	X	70586171	70586171	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:70586171C>A	ENST00000449580.1	+	1	58	c.7C>A	c.(7-9)Ccc>Acc	p.P3T	TAF1_ENST00000373790.4_Missense_Mutation_p.P3T|TAF1_ENST00000276072.3_Missense_Mutation_p.P3T|TAF1_ENST00000423759.1_Missense_Mutation_p.P3T			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	3	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GTCTATGGGACCCGGCTGCGA	0.567000													11	63					1.05317e-09	1.43006e-09	0.457914	1	0
CES5A	221223	broad.mit.edu	37	16	55909090	55909090	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:55909090G>T	ENST00000290567.9	-	1	165	c.44C>A	c.(43-45)gCt>gAt	p.A15D	CES5A_ENST00000518005.1_Intron|CES5A_ENST00000319165.9_Missense_Mutation_p.A15D|CES5A_ENST00000520435.1_Missense_Mutation_p.A15D|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000521992.1_Intron	NM_001143685.1	NP_001137157.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	15						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GACCCAGATAGCCCAAATTAG	0.552000													35	40					4.07013e-28	8.09724e-28	0.840704	1	0
AKR1E2	83592	broad.mit.edu	37	10	4872963	4872963	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:4872963G>T	ENST00000298375.7	+	2	207	c.136G>T	c.(136-138)Gtt>Ttt	p.V46F	AKR1E2_ENST00000334019.4_Missense_Mutation_p.V46F|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000532248.1_Missense_Mutation_p.V46F|AKR1E2_ENST00000345253.5_Missense_Mutation_p.V46F	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	46						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						TGAGAGGGAGGTTGGAGCAGG	0.542000													35	69					1.36161e-19	2.43127e-19	0.796494	1	0
OBSCN	84033	broad.mit.edu	37	1	228402014	228402014	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:228402014G>T	ENST00000570156.2	+	4	1472	c.1398G>T	c.(1396-1398)gtG>gtT	p.V466V	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.V466V|OBSCN_ENST00000284548.11_Silent_p.V466V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	466	Ig-like 5.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGGCCGCGTGGCCATCTCCG	0.687000													4	82					0.150653	0.152846	0.150653	1	0
WDR6	11180	broad.mit.edu	37	3	49050635	49050635	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:49050635G>T	ENST00000395474.3	+	2	2038	c.1758G>T	c.(1756-1758)ggG>ggT	p.G586G	WDR6_ENST00000415265.2_Intron|WDR6_ENST00000448293.1_Silent_p.G505G|WDR6_ENST00000489684.1_Intron	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	556					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CTTTCACTGGGTTGGGCCCAG	0.612000													24	25					3.7963e-18	6.53075e-18	0.654019	1	0
STK19	8859	broad.mit.edu	37	6	31948260	31948260	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:31948260G>T	ENST00000375331.2	+	6	1002	c.836G>T	c.(835-837)cGa>cTa	p.R279L	STK19_ENST00000375333.2_Missense_Mutation_p.R283L	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	283						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						CTCACCGTCCGAGATGCTGGG	0.567000													4	54					5.9392e-07	7.24875e-07	0.217242	1	0
TXNRD1	7296	broad.mit.edu	37	12	104645403	104645403	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:104645403G>T	ENST00000525566.1	+	2	214	c.190G>T	c.(190-192)Gat>Tat	p.D64Y	TXNRD1_ENST00000526006.1_3'UTR|TXNRD1_ENST00000429002.2_Missense_Mutation_p.D64Y	NM_001093771.2	NP_001087240.1	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	64	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						GGCCTATATAGATGGTCACTC	0.478000													19	47					7.92952e-12	1.16863e-11	0.667858	1	0
PPP1R12B	4660	broad.mit.edu	37	1	202462301	202462301	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:202462301G>T	ENST00000406302.3	+	15	2154	c.2001G>T	c.(1999-2001)gaG>gaT	p.E667D	PPP1R12B_ENST00000391959.3_5'UTR|PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000367270.4_5'UTR|PPP1R12B_ENST00000336894.4_Missense_Mutation_p.E667D	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	667					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			CGAGGGCAGAGAGGCAAGCTC	0.547000													29	96					3.57733e-08	4.58619e-08	0.740014	1	0
CHIT1	1118	broad.mit.edu	37	1	203192643	203192643	+	Missense_Mutation	SNP	G	G	T	rs142999142		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:203192643G>T	ENST00000367229.1	-	5	494	c.460C>A	c.(460-462)Cgc>Agc	p.R154S	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Missense_Mutation_p.R145S|CHIT1_ENST00000255427.3_Missense_Mutation_p.R135S	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	154					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GTTGTGAAGCGCTCCTTGTCT	0.622000													14	75					6.94344e-10	9.5106e-10	0.539581	1	0
SYCP2L	221711	broad.mit.edu	37	6	10955441	10955441	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:10955441G>T	ENST00000283141.6	+	24	2343	c.2047G>T	c.(2047-2049)Gag>Tag	p.E683*		NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	683						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AGAAGAAAGAGAGTTGCCAGG	0.448000											OREG0017189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	70					8.33888e-18	1.42671e-17	0.870114	1	0
JPH2	57158	broad.mit.edu	37	20	42788415	42788415	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:42788415C>A	ENST00000372980.3	-	2	1884	c.1012G>T	c.(1012-1014)Gag>Tag	p.E338*		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	338					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane		p.E338K(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TACTTGCCCTCCTCGCGGTGG	0.652000													23	59					9.39395e-14	1.45629e-13	0.706142	1	0
WDR77	79084	broad.mit.edu	37	1	111991375	111991375	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:111991375C>G	ENST00000235090.5	-	2	373	c.167G>C	c.(166-168)gGc>gCc	p.G56A	WDR77_ENST00000411751.2_Missense_Mutation_p.G56A	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	56					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCAGAGGGAGCCGGCCCAGCA	0.652000													4	9					0	0	0.150653	0	0
KIAA1109	84162	broad.mit.edu	37	4	123275169	123275169	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:123275169G>T	ENST00000264501.4	+	82	14675	c.14302G>T	c.(14302-14304)Gaa>Taa	p.E4768*	KIAA1109_ENST00000388738.3_Nonsense_Mutation_p.E4768*			Q2LD37	K1109_HUMAN	KIAA1109	4768					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TACAAGGAATGAAGGTTAAAA	0.353000													4	11					0.00909568	0.00946796	0.150653	1	0
KDR	3791	broad.mit.edu	37	4	55955613	55955613	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:55955613A>G	ENST00000263923.4	-	25	3627	c.3332T>C	c.(3331-3333)aTt>aCt	p.I1111T	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1111	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTCTTCATCAATCTTTACCCC	0.383000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			79	119					0	0	0.870114	0	0
EXTL3	2137	broad.mit.edu	37	8	28575347	28575347	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:28575347C>A	ENST00000220562.4	+	3	2673	c.1771C>A	c.(1771-1773)Cgc>Agc	p.R591S	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Missense_Mutation_p.R207S	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	591						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CAGATACCTCCGCAATTTCAC	0.597000													30	51					8.16721e-17	1.36024e-16	0.750413	1	0
EXOC3L4	91828	broad.mit.edu	37	14	103568723	103568723	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:103568723G>T	ENST00000380069.3	+	2	739	c.663G>T	c.(661-663)gaG>gaT	p.E221D		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	221										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						TGAGCGCGGAGGAGGAAGCCC	0.756000													9	9					2.80697e-09	3.77607e-09	0.387290	1	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950718	209950718	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:209950718C>A	ENST00000367024.1	+	12	1591	c.1075C>A	c.(1075-1077)Cag>Aag	p.Q359K	TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.Q359K|TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.Q339K|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.Q339K|TRAF3IP3_ENST00000477431.1_Missense_Mutation_p.Q95K|TRAF3IP3_ENST00000367023.1_Missense_Mutation_p.Q95K|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.Q339K			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	359						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAGGGACTTACAGATGAACCA	0.547000													12	93					1.5842e-08	2.06902e-08	0.435327	1	0
R3HDM2	22864	broad.mit.edu	37	12	57662750	57662750	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:57662750C>A	ENST00000402412.1	-	17	2220	c.1830G>T	c.(1828-1830)caG>caT	p.Q610H	R3HDM2_ENST00000347140.3_Missense_Mutation_p.Q596H|R3HDM2_ENST00000403821.2_Missense_Mutation_p.Q630H|R3HDM2_ENST00000441731.2_Missense_Mutation_p.Q291H|R3HDM2_ENST00000413953.2_Missense_Mutation_p.Q323H|R3HDM2_ENST00000393811.2_Missense_Mutation_p.Q323H|RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000358907.2_Missense_Mutation_p.Q596H			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	596	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GGCCTTGCATCTGGCCCCCCA	0.587000													44	112					1.21353e-23	2.30461e-23	0.870114	1	0
ATXN7	6314	broad.mit.edu	37	3	63965832	63965832	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:63965832C>T	ENST00000398590.3	+	6	1294	c.741C>T	c.(739-741)ccC>ccT	p.P247P	ATXN7_ENST00000295900.6_Silent_p.P247P|ATXN7_ENST00000538065.1_Silent_p.P247P|ATXN7_ENST00000488239.1_3'UTR|ATXN7_ENST00000487717.1_Silent_p.P247P|ATXN7_ENST00000484332.1_Silent_p.P102P	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	247					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		GTAGAGTTCCCCATGGTAGAA	0.458000													20	24					0	0	0.681144	0	0
TRIML2	205860	broad.mit.edu	37	4	189022368	189022368	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:189022368C>A	ENST00000512729.1	-	3	546	c.172G>T	c.(172-174)Gag>Tag	p.E58*	TRIML2_ENST00000326754.3_Nonsense_Mutation_p.E58*|TRIML2_ENST00000536972.1_Nonsense_Mutation_p.E108*	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	58							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ATACTATACTCAGACTCAATC	0.388000													10	43					0.000219431	0.000242496	0.457914	1	0
ZZZ3	26009	broad.mit.edu	37	1	78047528	78047528	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:78047528C>G	ENST00000370801.3	-	8	2316	c.1841G>C	c.(1840-1842)gGa>gCa	p.G614A	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Missense_Mutation_p.G120A	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						AAGGGACTCTCCATCCTTCTT	0.403000													16	20					0	0	0.592651	0	0
XPC	7508	broad.mit.edu	37	3	14199836	14199836	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:14199836T>A	ENST00000285021.7	-	9	1761	c.1547A>T	c.(1546-1548)gAt>gTt	p.D516V	XPC_ENST00000449060.2_Missense_Mutation_p.D479V	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	516	Interaction with RAD23B.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTTCTCACCATCGCTGCACAT	0.517000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				15	48					0	0	0.539581	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473687	53473687	+	RNA	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:53473687G>C	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							ATGGGTTTTAGGAATACAAGA	0.363000													8	5					0	0	0.278610	0	0
AKAP8	10270	broad.mit.edu	37	19	15484656	15484656	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:15484656G>A	ENST00000269701.2	-	4	372	c.312C>T	c.(310-312)tcC>tcT	p.S104S		NM_005858.3	NP_005849.1	O43823	AKAP8_HUMAN	A kinase (PRKA) anchor protein 8	104					signal transduction	nuclear matrix				breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)	26						CTCCTTCCTTGGACATCATGT	0.637000													18	31					0	0	0.624587	0	0
ARNT2	9915	broad.mit.edu	37	15	80806716	80806716	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:80806716A>G	ENST00000533983.1	+	9	1153	c.814A>G	c.(814-816)Aca>Gca	p.T272A	ARNT2_ENST00000303329.4_Missense_Mutation_p.T283A|ARNT2_ENST00000527771.1_Missense_Mutation_p.T272A			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	283					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGTCCACTGTACAGGATACAT	0.483000													40	93					0	0	0.870114	0	0
LIN7C	55327	broad.mit.edu	37	11	27528279	27528279	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:27528279G>T	ENST00000278193.2	-	1	41	c.21C>A	c.(19-21)ccC>ccA	p.P7P	LIN7C_ENST00000524596.1_Silent_p.P7P	NM_018362.3	NP_060832.1	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C (C. elegans)	7					exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction				endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCAGCCGCACGGGTTCCCCTA	0.672000													54	66					1.34159e-35	2.8148e-35	0.870114	1	0
BAGE2	85319	broad.mit.edu	37	21	11038893	11038893	+	RNA	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:11038893C>G	ENST00000470054.1	-	0	1310									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAGGCAAGTCTGAAGAAGGT	0.423000													49	297					0	0	0.870114	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627610	43627610	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:43627610G>T	ENST00000332857.6	-	4	1105	c.1077C>A	c.(1075-1077)caC>caA	p.H359Q		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		AAGAATTTAAGTGCTTTTCTG	0.423000													127	30					2.21597e-76	5.0307e-76	0.870114	1	0
SMOC1	64093	broad.mit.edu	37	14	70477558	70477558	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:70477558G>T	ENST00000381280.4	+	8	1005	c.752G>T	c.(751-753)tGt>tTt	p.C251F	SMOC1_ENST00000361956.3_Missense_Mutation_p.C251F	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	251	Thyroglobulin type-1 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATCCCTGAATGTGCCCCTGGG	0.592000													42	96					1.61004e-24	3.08563e-24	0.870114	1	0
SVIL	6840	broad.mit.edu	37	10	29839887	29839887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:29839887G>A	ENST00000375398.2	-	8	915	c.466C>T	c.(466-468)Cag>Tag	p.Q156*	SVIL_ENST00000375400.3_Nonsense_Mutation_p.Q156*|SVIL_ENST00000355867.4_Nonsense_Mutation_p.Q156*			O95425	SVIL_HUMAN	supervillin	156	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				GACTCTTCCTGTTTGTCACTT	0.557000													25	41					0	0	0.717897	0	0
DCDC1	341019	broad.mit.edu	37	11	31112973	31112973	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:31112973G>C	ENST00000597505.1	-	15	2203	c.2204C>G	c.(2203-2205)tCa>tGa	p.S735*	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TCCTTCTAGTGATGTTCCCTC	0.378000													4	16					0	0	0.150653	0	0
CCDC74B	91409	broad.mit.edu	37	2	130900037	130900037	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:130900037C>G	ENST00000392984.3	-	2	1262	c.519G>C	c.(517-519)ggG>ggC	p.G173G	CCDC74B_ENST00000409943.3_Intron|CCDC74B_ENST00000409128.1_Intron|CCDC74B_ENST00000310463.6_Intron			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	155										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TGTCAGCGTCCCCAGCACTGC	0.642000													10	19					0	0	0.387290	0	0
OR51E1	143503	broad.mit.edu	37	11	4674175	4674175	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4674175C>A	ENST00000396952.5	+	2	1069	c.419C>A	c.(418-420)aCg>aAg	p.T140K	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTACTTACGTTGCCTCGT	0.577000													35	89					1.02591e-13	1.58779e-13	0.853193	1	0
RIMS2	9699	broad.mit.edu	37	8	104897988	104897988	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:104897988G>T	ENST00000507740.1	+	2	821	c.585G>T	c.(583-585)agG>agT	p.R195S	RIMS2_ENST00000522174.1_3'UTR|RIMS2_ENST00000436393.2_Missense_Mutation_p.R165S|RIMS2_ENST00000262231.10_Missense_Mutation_p.R195S|RIMS2_ENST00000406091.3_Missense_Mutation_p.R387S	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	418					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTATGCTAAGGATGGATCGAC	0.463000										HNSCC(12;0.0054)			7	43					0.307466	0.309605	0.307466	1	0
KCTD7	154881	broad.mit.edu	37	7	66270309	66270309	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:66270309A>G	ENST00000380828.2	+	10	1277	c.1123A>G	c.(1123-1125)Atc>Gtc	p.I375V	KCTD7_ENST00000451741.2_Missense_Mutation_p.I335V|RABGEF1_ENST00000484547.2_3'UTR|RABGEF1_ENST00000450873.2_Missense_Mutation_p.I335V|RABGEF1_ENST00000284957.5_Missense_Mutation_p.I335V|KCTD7_ENST00000510829.2_Missense_Mutation_p.I335V|RABGEF1_ENST00000437078.2_Missense_Mutation_p.I349V|RABGEF1_ENST00000439720.2_Missense_Mutation_p.I348V			Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	0						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						TCAGTCTAATATCCAGTATAT	0.498000													33	98					0	0	0.827153	0	0
KIAA1024	23251	broad.mit.edu	37	15	79749799	79749799	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:79749799C>G	ENST00000305428.3	+	2	1385	c.1310C>G	c.(1309-1311)tCt>tGt	p.S437C		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	437						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						GGGCTCAAATCTAAAGAGATC	0.473000													15	48					0	0	0.520397	0	0
GRIK3	2899	broad.mit.edu	37	1	37270610	37270610	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:37270610C>A	ENST00000373091.3	-	15	2559	c.2543G>T	c.(2542-2544)cGc>cTc	p.R848L	GRIK3_ENST00000373093.4_Missense_Mutation_p.R848L	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	848					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity	p.R848H(1)		breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGCTGTTTTGCGGAGCTTGTA	0.582000													26	47					1.77063e-15	2.85792e-15	0.693898	1	0
MFN1	55669	broad.mit.edu	37	3	179085889	179085889	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:179085889G>T	ENST00000471841.1	+	9	1099	c.973G>T	c.(973-975)Gag>Tag	p.E325*	MFN1_ENST00000280653.7_Nonsense_Mutation_p.E325*|MFN1_ENST00000263969.5_Nonsense_Mutation_p.E325*	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	325					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ACAAATCTTTGAGGTAGGAAT	0.328000													6	24					0.0293803	0.0301822	0.248553	1	0
OR2L8	391190	broad.mit.edu	37	1	248112854	248112854	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:248112854G>T	ENST00000357191.3	+	1	695	c.695G>T	c.(694-696)gGg>gTg	p.G232V	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCTGCAGAAGGGAGGAAGAAA	0.448000													19	167					1.5548e-18	2.69938e-18	0.693898	1	0
THY1	7070	broad.mit.edu	37	11	119291587	119291587	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:119291587A>T	ENST00000284240.5	-	2	1068	c.29T>A	c.(28-30)cTg>cAg	p.L10Q	THY1_ENST00000580275.1_Missense_Mutation_p.L10Q|USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000500970.1_RNA|THY1_ENST00000528522.1_Missense_Mutation_p.L10Q|THY1_ENST00000527590.1_Intron|USP2-AS1_ENST00000498979.2_RNA|USP2-AS1_ENST00000578923.1_RNA	NM_006288.3	NP_006279.2	P04216	THY1_HUMAN	Thy-1 cell surface antigen	10					angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		ACCTGTTAGCAGGAGAGCGAT	0.597000													24	204					0	0	0.779181	0	0
NEB	4703	broad.mit.edu	37	2	152470889	152470889	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:152470889T>A	ENST00000427231.2	-	77	11704	c.11502A>T	c.(11500-11502)gtA>gtT	p.V3834V	NEB_ENST00000397345.3_Silent_p.V3834V|NEB_ENST00000409198.1_Silent_p.V3591V|NEB_ENST00000172853.10_Silent_p.V3591V|NEB_ENST00000603639.1_Silent_p.V3834V|NEB_ENST00000604864.1_Silent_p.V3834V	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3834					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTATGTCGCTTACAAGGATCT	0.527000													40	106					0	0	0.859065	0	0
GPR12	2835	broad.mit.edu	37	13	27333319	27333319	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:27333319G>T	ENST00000405846.3	-	2	867	c.646C>A	c.(646-648)Ctc>Atc	p.L216I	GPR12_ENST00000381436.2_Missense_Mutation_p.L216I	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	216						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		TGGATGTAGAGCTGAAGCATG	0.572000													20	64					1.1804e-14	1.86524e-14	0.667858	1	0
CD22	933	broad.mit.edu	37	19	35831821	35831821	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:35831821C>A	ENST00000085219.5	+	7	1353	c.1287C>A	c.(1285-1287)ccC>ccA	p.P429P	CD22_ENST00000536635.2_Silent_p.P341P|CD22_ENST00000270311.6_Silent_p.P309P|CD22_ENST00000341773.6_Silent_p.P252P|CD22_ENST00000419549.2_Silent_p.P257P|CD22_ENST00000594250.1_Silent_p.P252P|CD22_ENST00000544992.2_Silent_p.P429P	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	429	Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTCAAAACCCCATGCCGATTC	0.512000													5	46					0.248553	0.250818	0.248553	1	0
HDDC2	51020	broad.mit.edu	37	6	125598374	125598374	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:125598374G>T	ENST00000398153.1	-	5	594	c.391C>A	c.(391-393)Caa>Aaa	p.Q131K	HDDC2_ENST00000368377.4_Missense_Mutation_p.Q97K	NM_016063.2	NP_057147.2	Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	131	HD.			Q -> R (in Ref. 5; AAH66332).			metal ion binding|phosphoric diester hydrolase activity			endometrium(1)|large_intestine(1)|lung(4)	6			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)		GCACTAGATTGGGTCTCGTAC	0.423000													18	69					7.87624e-14	1.22708e-13	0.639603	1	0
TPTE2	93492	broad.mit.edu	37	13	20025312	20025312	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:20025312A>T	ENST00000400230.2	-	11	839	c.795T>A	c.(793-795)aaT>aaA	p.N265K	TPTE2_ENST00000382975.4_Missense_Mutation_p.N225K|TPTE2_ENST00000400103.2_Missense_Mutation_p.N154K|TPTE2_ENST00000255310.6_Missense_Mutation_p.N188K|TPTE2_ENST00000390680.2_Missense_Mutation_p.N188K|TPTE2_ENST00000382978.1_Missense_Mutation_p.N225K|TPTE2_ENST00000457266.2_Missense_Mutation_p.N154K|TPTE2_ENST00000382977.4_Missense_Mutation_p.N265K			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	265	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TACTGCATAGATTGTAGACTC	0.333000													7	66					0	0	0.411799	0	0
ABCB1	5243	broad.mit.edu	37	7	87133575	87133575	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:87133575C>G	ENST00000265724.3	-	29	4244	c.3827G>C	c.(3826-3828)gGa>gCa	p.G1276A	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.G1212A	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1276					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCGCTTTGTTCCAGCCTGGAC	0.398000													30	89					0	0	0.760397	0	0
DENND5B	160518	broad.mit.edu	37	12	31604911	31604911	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:31604911C>A	ENST00000389082.5	-	5	1856	c.1592G>T	c.(1591-1593)tGg>tTg	p.W531L	DENND5B_ENST00000354285.4_Missense_Mutation_p.W553L|DENND5B_ENST00000536562.1_Missense_Mutation_p.W566L|DENND5B_ENST00000306833.6_Missense_Mutation_p.W566L	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	531	dDENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GTTGGTCAGCCAGGATTCCAT	0.398000													4	22					5.9392e-07	7.24875e-07	0.217242	1	0
PIK3R5	23533	broad.mit.edu	37	17	8784067	8784067	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:8784067G>T	ENST00000447110.1	-	19	2656	c.2532C>A	c.(2530-2532)agC>agA	p.S844R	PIK3R5_ENST00000584803.1_Missense_Mutation_p.S843R|PIK3R5_ENST00000581552.1_Missense_Mutation_p.S844R	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	844					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						AGGAGAGGTCGCTCTTCTCTG	0.637000													10	23					1.05317e-09	1.43006e-09	0.457914	1	0
ZFHX4	79776	broad.mit.edu	37	8	77775885	77775885	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:77775885C>A	ENST00000521891.2	+	11	10383	c.9935C>A	c.(9934-9936)cCa>cAa	p.P3312Q	ZFHX4_ENST00000455469.2_Missense_Mutation_p.P3267Q|ZFHX4_ENST00000050961.6_Missense_Mutation_p.P3263Q|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P3286Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3263						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GGTCTGTCCCCAGGTGCACTG	0.547000										HNSCC(33;0.089)			3	11					0.115264	0.117385	0.115264	1	0
ACACB	32	broad.mit.edu	37	12	109644547	109644547	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:109644547G>T	ENST00000338432.7	+	20	3065	c.2946G>T	c.(2944-2946)caG>caT	p.Q982H	ACACB_ENST00000377854.5_Missense_Mutation_p.Q982H|ACACB_ENST00000377848.3_Missense_Mutation_p.Q982H			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	982					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCCCTGCCCAGCAGACACTGC	0.557000													57	170					6.26901e-30	1.2632e-29	0.870114	1	0
KCNK13	56659	broad.mit.edu	37	14	90528647	90528647	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:90528647G>A	ENST00000282146.4	+	1	539	c.98G>A	c.(97-99)gGc>gAc	p.G33D		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	33						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TACCTGCTGGGCGGCGCCGCC	0.716000													4	10					0	0	0.248553	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541571	95541571	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:95541571C>A	ENST00000297591.5	-	7	683		c.e7-1		KIAA1429_ENST00000437199.1_Splice_Site|KIAA1429_ENST00000421249.2_Splice_Site	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429						mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCACCAGACACTGAAAAATTG	0.388000													4	38					0.000602214	0.000654747	0.184627	1	0
NAGA	4668	broad.mit.edu	37	22	42462723	42462723	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:42462723G>A	ENST00000396398.3	-	5	1120	c.588C>T	c.(586-588)ctC>ctT	p.L196L	NAGA_ENST00000403363.1_Silent_p.L196L|NAGA_ENST00000402937.1_Silent_p.L196L	NM_000262.2	NP_000253.1	P17050	NAGAB_HUMAN	N-acetylgalactosaminidase, alpha-	196					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						CCCTTGGGGGGAGGCCGCCTT	0.647000													8	4					0	0	0.361761	0	0
STX3	6809	broad.mit.edu	37	11	59556353	59556353	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:59556353G>C	ENST00000535361.1	+	4	769	c.222G>C	c.(220-222)aaG>aaC	p.K74N	STX3_ENST00000529177.1_Missense_Mutation_p.K74N|STX3_ENST00000437946.2_5'UTR|STX3_ENST00000300150.7_Missense_Mutation_p.K43N|STX3_ENST00000337979.4_Missense_Mutation_p.K74N			Q13277	STX3_HUMAN	syntaxin 3	74					cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|skin(1)	13						CAGAAACCAAGGATGACCTAG	0.463000													7	14					0	0	0.335167	0	0
ITLN2	142683	broad.mit.edu	37	1	160920494	160920494	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:160920494C>A	ENST00000368029.3	-	5	506	c.449G>T	c.(448-450)gGc>gTc	p.G150V	ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	150	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCGTAGTAGCCAGGGTTCTG	0.602000													48	40					3.21867e-24	6.15604e-24	0.870114	1	0
WDR33	55339	broad.mit.edu	37	2	128525865	128525865	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:128525865C>A	ENST00000322313.4	-	4	434	c.276G>T	c.(274-276)ctG>ctT	p.L92L	WDR33_ENST00000393006.1_Silent_p.L92L|WDR33_ENST00000409658.3_Silent_p.L92L	NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	92					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TAGGTGGGACCAGCTACAAAA	0.343000													3	12					1.23904e-05	1.42622e-05	0.184627	1	0
ZNF530	348327	broad.mit.edu	37	19	58117834	58117834	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:58117834A>T	ENST00000332854.6	+	3	1161	c.941A>T	c.(940-942)cAa>cTa	p.Q314L	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATTCAACATCAACGAGTTCAC	0.473000													62	66					0	0	0.870114	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135106005	135106005	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:135106005G>A	ENST00000368563.2	-	8	1568	c.1212C>T	c.(1210-1212)taC>taT	p.Y404Y	TUBGCP2_ENST00000543663.1_Silent_p.Y432Y|TUBGCP2_ENST00000252936.3_Silent_p.Y404Y|TUBGCP2_ENST00000417178.2_Silent_p.Y274Y	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	404					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		AGCCCTACCTGTATGGGTCGT	0.627000													20	31					0	0	0.654019	0	0
MFSD8	256471	broad.mit.edu	37	4	128865093	128865093	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:128865093G>C	ENST00000296468.3	-	5	380	c.253C>G	c.(253-255)Ctt>Gtt	p.L85V	MFSD8_ENST00000515130.1_5'UTR|MFSD8_ENST00000513559.1_Missense_Mutation_p.L40V|MFSD8_ENST00000541133.1_Missense_Mutation_p.L40V	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	85					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						ATTTGGCCAAGACTATATGAA	0.388000													14	53					0	0	0.520397	0	0
TBC1D4	9882	broad.mit.edu	37	13	75936222	75936222	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:75936222C>A	ENST00000377636.3	-	2	1366	c.1020G>T	c.(1018-1020)gcG>gcT	p.A340A	TBC1D4_ENST00000377625.2_Silent_p.A340A|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000431480.2_Silent_p.A340A	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	340	PID 2.					cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TGGGTGCGCTCGCGTGTCTCC	0.622000													18	81					9.57634e-11	1.3602e-10	0.654019	1	0
MCF2	4168	broad.mit.edu	37	X	138672050	138672050	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:138672050C>T	ENST00000520602.1	-	23	2779	c.2494G>A	c.(2494-2496)Gat>Aat	p.D832N	MCF2_ENST00000414978.1_Missense_Mutation_p.D832N|MCF2_ENST00000370573.4_Missense_Mutation_p.D772N|MCF2_ENST00000370576.4_Missense_Mutation_p.D772N|MCF2_ENST00000536274.1_Missense_Mutation_p.D733N|MCF2_ENST00000370578.4_Missense_Mutation_p.D917N|MCF2_ENST00000519895.1_Missense_Mutation_p.D848N|MCF2_ENST00000338585.6_Missense_Mutation_p.D788N			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	772					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTGCGGTTATCACCTTTTACA	0.299000													4	68					0	0	0.184627	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650577	121650577	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:121650577G>T	ENST00000393386.2	+	12	1888	c.1477G>T	c.(1477-1479)Ggt>Tgt	p.G493C	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.G493C	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	493					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTCTGGAAAGGGTGATGTTCC	0.413000													25	41					1.26454e-06	1.52948e-06	0.693898	1	0
KIDINS220	57498	broad.mit.edu	37	2	8871203	8871203	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:8871203C>T	ENST00000256707.3	-	30	5144	c.4963G>A	c.(4963-4965)Gaa>Aaa	p.E1655K	KIDINS220_ENST00000473731.1_Missense_Mutation_p.E1636K|KIDINS220_ENST00000427284.1_Missense_Mutation_p.E1636K|KIDINS220_ENST00000418530.1_Missense_Mutation_p.E1556K	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1655					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AAGCTGCATTCGGAAGGGCTT	0.512000													10	56					0	0	0.361761	0	0
IER2	9592	broad.mit.edu	37	19	13264469	13264469	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:13264469G>T	ENST00000588173.1	+	1	1681	c.469G>T	c.(469-471)Gcc>Tcc	p.A157S	CTC-250I14.6_ENST00000586483.1_RNA|IER2_ENST00000587885.1_Missense_Mutation_p.A157S|IER2_ENST00000292433.3_Missense_Mutation_p.A157S|CTC-250I14.6_ENST00000592882.1_RNA			Q9BTL4	IER2_HUMAN	immediate early response 2	157										kidney(1)|lung(1)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			ATCCGAAGTCGCCGATCGCCT	0.677000											OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	11					2.80697e-09	3.77607e-09	0.387290	1	0
FER1L6	654463	broad.mit.edu	37	8	125113405	125113405	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:125113405G>T	ENST00000522917.1	+	38	5157	c.4951G>T	c.(4951-4953)Ggc>Tgc	p.G1651C	FER1L6_ENST00000399018.1_Missense_Mutation_p.G1651C|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1651	C2 6.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GACTGGAGAGGGCAACTTCAA	0.428000													12	79					1.41608e-15	2.30143e-15	0.435327	1	0
RYR2	6262	broad.mit.edu	37	1	237870363	237870363	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237870363C>A	ENST00000366574.2	+	68	10012	c.9695C>A	c.(9694-9696)cCa>cAa	p.P3232Q	RYR2_ENST00000542537.1_Missense_Mutation_p.P3216Q|RYR2_ENST00000360064.6_Missense_Mutation_p.P3230Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3232					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTCAAATGCCACATGTCATG	0.488000													41	84					6.5261e-18	1.11961e-17	0.840704	1	0
NRXN1	9378	broad.mit.edu	37	2	50724471	50724471	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:50724471C>A	ENST00000404971.1	-	15	4338	c.2999_splice	c.e15+1	p.G1000_splice	NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Splice_Site_p.G952_splice|NRXN1_ENST00000405472.3_Splice_Site_p.G952_splice|NRXN1_ENST00000401669.2_Splice_Site_p.G960_splice|NRXN1_ENST00000406316.2_Splice_Site_p.G960_splice|NRXN1_ENST00000406859.3_Splice_Site_p.G960_splice	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	960	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATGTACTCACCCTTTAACTAA	0.333000													8	18					9.70103e-10	1.32204e-09	0.361761	1	0
PNPLA4	8228	broad.mit.edu	37	X	7870120	7870120	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:7870120G>A	ENST00000381042.4	-	6	710	c.540C>T	c.(538-540)acC>acT	p.T180T	PNPLA4_ENST00000444736.1_Silent_p.T180T|PNPLA4_ENST00000537427.1_Silent_p.T93T	NM_004650.2	NP_004641.1	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	180					lipid catabolic process		triglyceride lipase activity			kidney(1)|large_intestine(3)|lung(2)|prostate(1)	7		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				AGGGGGAGATGGTTACTGTCC	0.537000													25	26					0	0	0.681144	0	0
MED17	9440	broad.mit.edu	37	11	93521248	93521248	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:93521248T>G	ENST00000251871.3	+	2	619	c.332T>G	c.(331-333)gTt>gGt	p.V111G	MED17_ENST00000530819.1_Missense_Mutation_p.V111G	NM_004268.4	NP_004259.3	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	111					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(2)|lung(11)|ovary(1)	14		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAGATGTGTGTTCTCTATGAT	0.408000													12	103					0	0	0.411799	0	0
OR8K5	219453	broad.mit.edu	37	11	55927573	55927573	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55927573G>T	ENST00000313447.1	-	1	220	c.221C>A	c.(220-222)tCt>tAt	p.S74Y		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				AATGACAGTAGAATTACCAAG	0.393000													48	83					1.32667e-27	2.62268e-27	0.870114	1	0
ZNF628	89887	broad.mit.edu	37	19	55992757	55992757	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55992757G>T	ENST00000391718.2	+	3	750	c.185G>T	c.(184-186)tGc>tTc	p.C62F	ZNF628_ENST00000598519.1_Missense_Mutation_p.C66F			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	62						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CCCTACAAGTGCCCAGACTGC	0.672000													12	40					0.00316338	0.00335975	0.479597	1	0
CST9	128822	broad.mit.edu	37	20	23584266	23584266	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:23584266G>T	ENST00000376971.3	-	2	372	c.361C>A	c.(361-363)Ctg>Atg	p.L121M		NM_001008693.2	NP_001008693.2	Q5W186	CST9_HUMAN	cystatin 9 (testatin)	121						extracellular region	cysteine-type endopeptidase inhibitor activity			central_nervous_system(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Colorectal(13;0.0993)					ACGTTGTTCAGCTCCAGGCTT	0.502000													17	90					7.45023e-12	1.09971e-11	0.592651	1	0
KRT19	3880	broad.mit.edu	37	17	39680183	39680183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:39680183G>A	ENST00000361566.3	-	6	1075	c.1015C>T	c.(1015-1017)Cag>Tag	p.Q339*		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				ATCAGCGCCTGGATATGCGCC	0.592000													18	37					0	0	0.539581	0	0
NDC1	55706	broad.mit.edu	37	1	54262708	54262708	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:54262708C>G	ENST00000371429.3	-	12	1930	c.1332G>C	c.(1330-1332)gtG>gtC	p.V444V	NDC1_ENST00000234725.8_Silent_p.V329V|NDC1_ENST00000537333.1_Silent_p.V109V|NDC1_ENST00000540001.1_Silent_p.V444V	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		CAAATGGGCTCACAACATCAG	0.438000													7	44					0	0	0.278610	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235201	5235201	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:5235201G>T	ENST00000274181.7	+	13	2063	c.1925G>T	c.(1924-1926)cGg>cTg	p.R642L	ADAMTS16_ENST00000513709.1_3'UTR	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	642	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AAATGTCCCCGGGACAGTGTT	0.522000													12	257					1.05317e-09	1.43006e-09	0.457914	1	0
CD226	10666	broad.mit.edu	37	18	67563020	67563020	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:67563020G>A	ENST00000280200.4	-	4	912	c.644C>T	c.(643-645)tCa>tTa	p.S215L	CD226_ENST00000581982.1_Missense_Mutation_p.S60L|CD226_ENST00000577287.1_Missense_Mutation_p.S60L|CD226_ENST00000582621.1_Missense_Mutation_p.S215L	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	215	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				CCCCGAGTCTGAGACTGTGAC	0.542000													17	62					0	0	0.557998	0	0
FAM189B	10712	broad.mit.edu	37	1	155223914	155223914	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:155223914C>T	ENST00000361361.2	-	3	863	c.354G>A	c.(352-354)aaG>aaA	p.K118K	FAM189B_ENST00000368368.3_Silent_p.K99K|FAM189B_ENST00000350210.2_Intron|FAM189B_ENST00000472550.1_Intron	NM_006589.2	NP_006580.2	P81408	F189B_HUMAN	family with sequence similarity 189, member B	118						integral to membrane	WW domain binding			breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23						GTTGAGCATTCTTACAGGAGA	0.547000													40	300					0	0	0.870114	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24922390	24922390	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:24922390G>C	ENST00000396432.2	-	6	867	c.381C>G	c.(379-381)gtC>gtG	p.V127V		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	126	PDZ.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TTTCTCCATTGACTTTTATAA	0.303000													5	39					0	0	0.307466	0	0
CACNA1E	777	broad.mit.edu	37	1	181701867	181701867	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:181701867C>A	ENST00000526775.1	+	19	2753	c.2588C>A	c.(2587-2589)cCa>cAa	p.P863Q	CACNA1E_ENST00000357570.5_Missense_Mutation_p.P833Q|CACNA1E_ENST00000367567.4_Missense_Mutation_p.P489Q|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P863Q|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P882Q|CACNA1E_ENST00000358338.5_Missense_Mutation_p.P814Q|CACNA1E_ENST00000367570.1_Missense_Mutation_p.P882Q	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	882					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGGGAGCCACCATGGCTGGCC	0.672000													10	40					0.000673444	0.000729241	0.361761	1	0
FOXL1	2300	broad.mit.edu	37	16	86612745	86612745	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:86612745G>T	ENST00000320241.3	+	1	631	c.416G>T	c.(415-417)cGg>cTg	p.R139L		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	139					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						GGCAACTACCGGCGCCGGAAG	0.731000													13	10					4.3838e-07	5.36431e-07	0.435327	1	0
SLC12A2	6558	broad.mit.edu	37	5	127507432	127507432	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:127507432G>A	ENST00000262461.2	+	19	2986	c.2797G>A	c.(2797-2799)Gga>Aga	p.G933R	SLC12A2_ENST00000343225.4_Missense_Mutation_p.G933R	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	933					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCATCTTCAAGGACAAGGTAA	0.289000													26	74					0	0	0.706142	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147869548	147869548	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:147869548T>C	ENST00000361727.3	+	18	3504	c.2988T>C	c.(2986-2988)taT>taC	p.Y996Y	CNTNAP2_ENST00000538075.1_Silent_p.Y55Y	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	996	EGF-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATACTGCATATGATGGAACAT	0.418000										HNSCC(39;0.1)			59	148					0	0	0.870114	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378388	31378388	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:31378388T>A	ENST00000297142.3	-	2	817	c.495A>T	c.(493-495)ttA>ttT	p.L165F		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	165					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GACCTTTGCATAAGTTTTGGA	0.498000													28	71					0	0	0.796494	0	0
OR10A3	26496	broad.mit.edu	37	11	7960585	7960585	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:7960585A>T	ENST00000360759.3	-	1	556	c.483T>A	c.(481-483)acT>acA	p.T161T		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TAAATACCCAAGTGGTCTGCA	0.423000													25	36					0	0	0.681144	0	0
DCTN4	51164	broad.mit.edu	37	5	150102501	150102501	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:150102501C>T	ENST00000447998.2	-	9	991	c.876G>A	c.(874-876)acG>acA	p.T292T	DCTN4_ENST00000424236.1_Silent_p.T235T|DCTN4_ENST00000446090.2_Silent_p.T299T	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	292						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTTGATTGACGTTGGGTTAA	0.343000													42	18					0	0	0.870114	0	0
TRPC7	57113	broad.mit.edu	37	5	135583384	135583384	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:135583384G>T	ENST00000513104.1	-	7	1901	c.1619C>A	c.(1618-1620)tCg>tAg	p.S540*	TRPC7_ENST00000426057.2_Nonsense_Mutation_p.S424*|TRPC7_ENST00000355180.3_Nonsense_Mutation_p.S479*	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	540					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAGCCCTTCCGATATGATCTG	0.522000													10	40					1.3612e-06	1.64112e-06	0.479597	1	0
RNF219	79596	broad.mit.edu	37	13	79190695	79190695	+	Missense_Mutation	SNP	T	T	A	rs143737295	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:79190695T>A	ENST00000282003.6	-	6	1259	c.1201A>T	c.(1201-1203)Agt>Tgt	p.S401C	RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000560584.2_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	401							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TCTGGAGTACTGAGCTGAAGG	0.423000													19	61					0	0	0.624587	0	0
GNB5	10681	broad.mit.edu	37	15	52442101	52442101	+	Missense_Mutation	SNP	C	C	A	rs11550544		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:52442101C>A	ENST00000261837.7	-	5	462	c.397G>T	c.(397-399)Gat>Tat	p.D133Y	GNB5_ENST00000560116.1_Missense_Mutation_p.D91Y|GNB5_ENST00000396335.4_Missense_Mutation_p.D91Y|GNB5_ENST00000358784.7_Missense_Mutation_p.D91Y	NM_016194.3	NP_057278.2	O14775	GBB5_HUMAN	guanine nucleotide binding protein (G protein), beta 5	133						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			large_intestine(1)|lung(1)	2				all cancers(107;0.0163)		GTGAAGGAATCCCACACGATC	0.498000													12	29					7.93312e-07	9.63234e-07	0.457914	1	0
GPR45	11250	broad.mit.edu	37	2	105858591	105858591	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:105858591C>G	ENST00000258456.1	+	1	392	c.276C>G	c.(274-276)gcC>gcG	p.A92A		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	92						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						CCTTCACCGCCGTCACCCTCA	0.632000													49	156					0	0	0.870114	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	60					0	0	0.115264	0	0
FER1L6	654463	broad.mit.edu	37	8	125047562	125047562	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:125047562C>T	ENST00000522917.1	+	19	2537	c.2331C>T	c.(2329-2331)gtC>gtT	p.V777V	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.V777V	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	777						integral to membrane		p.V777V(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCAAAAGTCGACGTGTACC	0.498000													11	138					0	0	0.435327	0	0
NFXL1	152518	broad.mit.edu	37	4	47887962	47887962	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:47887962G>T	ENST00000507489.1	-	13	1774	c.1598C>A	c.(1597-1599)aCa>aAa	p.T533K	NFXL1_ENST00000381538.3_Missense_Mutation_p.T533K|NFXL1_ENST00000329043.3_Missense_Mutation_p.T533K	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	533						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TGTCACCTTTGTATTGCCACA	0.453000													62	194					4.81439e-37	1.0215e-36	0.870114	1	0
LCE1E	353135	broad.mit.edu	37	1	152760109	152760109	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152760109C>A	ENST00000368770.3	+	2	387	c.334C>A	c.(334-336)Cag>Aag	p.Q112K	LCE1E_ENST00000368771.1_Missense_Mutation_p.Q112K	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	112	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGCAGCGGCCAGCACTCTGG	0.607000													41	107					2.0833e-19	3.69187e-19	0.870114	1	0
SYNJ1	8867	broad.mit.edu	37	21	34011221	34011221	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:34011221C>A	ENST00000382499.2	-	31	4028	c.4029G>T	c.(4027-4029)ccG>ccT	p.P1343P	SYNJ1_ENST00000433931.2_Silent_p.P1343P|SYNJ1_ENST00000322229.7_Silent_p.P1304P|SYNJ1_ENST00000382491.3_Silent_p.P1257P|SYNJ1_ENST00000357345.3_Silent_p.P1288P	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1304	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.P1304P(1)		breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GACTTACTTGCGGTTGTGAGG	0.408000													43	124					5.82388e-19	1.02054e-18	0.870114	1	0
C1orf74	148304	broad.mit.edu	37	1	209956458	209956458	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:209956458C>A	ENST00000294811.1	-	2	778	c.522G>T	c.(520-522)ggG>ggT	p.G174G		NM_152485.2	NP_689698.1	Q96LT6	CA074_HUMAN	chromosome 1 open reading frame 74	174										endometrium(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	15				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		CCAGGAGGATCCCAAATACAG	0.502000													83	79					1.63549e-45	3.5874e-45	0.870114	1	0
KIAA1109	84162	broad.mit.edu	37	4	123249264	123249264	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:123249264A>T	ENST00000264501.4	+	66	11374	c.11001A>T	c.(10999-11001)ccA>ccT	p.P3667P	KIAA1109_ENST00000388738.3_Silent_p.P3667P			Q2LD37	K1109_HUMAN	KIAA1109	3667					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ATCAGTTTCCAGAGGAGACAG	0.294000													7	15					0	0	0.307466	0	0
FOLR2	2350	broad.mit.edu	37	11	71932634	71932634	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:71932634G>A	ENST00000449475.2	+	5	882	c.584G>A	c.(583-585)gGg>gAg	p.G195E	FOLR2_ENST00000454954.2_Missense_Mutation_p.G158E|FOLR2_ENST00000298223.6_Missense_Mutation_p.G199E			P14207	FOLR2_HUMAN	folate receptor 2 (fetal)	199					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(3)|large_intestine(3)|ovary(1)|skin(1)	8					Folic Acid(DB00158)	TACAGCCGAGGGAGCGGCCGC	0.582000													32	79					0	0	0.779181	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129498	99129498	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:99129498C>T	ENST00000394170.2	+	7	2397	c.2146C>T	c.(2146-2148)Cct>Tct	p.P716S	ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.P716S|ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.P716S	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	716					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ACAAGAGCAGCCTTATCAGTG	0.398000													46	122					0	0	0.870114	0	0
SEZ6L	23544	broad.mit.edu	37	22	26706652	26706652	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:26706652G>T	ENST00000529632.2	+	7	1727	c.1531G>T	c.(1531-1533)Ggg>Tgg	p.G511W	SEZ6L_ENST00000248933.6_Missense_Mutation_p.G511W|SEZ6L_ENST00000403121.1_Missense_Mutation_p.G284W|SEZ6L_ENST00000360929.3_Missense_Mutation_p.G511W|SEZ6L_ENST00000402979.1_Missense_Mutation_p.G284W|SEZ6L_ENST00000404234.3_Missense_Mutation_p.G511W|SEZ6L_ENST00000343706.4_Missense_Mutation_p.G511W	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	511	CUB 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GGTTCACAGCGGGCAGACCAA	0.567000													36	172					3.54561e-26	6.89342e-26	0.847076	1	0
AHI1	54806	broad.mit.edu	37	6	135763846	135763846	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:135763846G>T	ENST00000367800.4	-	12	2002	c.1786C>A	c.(1786-1788)Cgt>Agt	p.R596S	AHI1_ENST00000327035.6_Missense_Mutation_p.R596S|AHI1_ENST00000457866.2_Missense_Mutation_p.R596S	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	596						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TTTGGGATACGGCAAGCCTAA	0.348000													5	15					0.0293803	0.0301822	0.248553	1	0
SERPINB9	5272	broad.mit.edu	37	6	2896343	2896343	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:2896343A>G	ENST00000380698.4	-	3	339	c.250T>C	c.(250-252)Tac>Cac	p.Y84H		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	84					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				CTCAGCAGGTACTGTGTGCCA	0.428000													9	84					0	0	0.335167	0	0
FRG1B	284802	broad.mit.edu	37	20	29623195	29623195	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:29623195G>C	ENST00000278882.3	+	3	387	c.7G>C	c.(7-9)Gaa>Caa	p.E3Q	FRG1B_ENST00000439954.2_Missense_Mutation_p.G4A|FRG1B_ENST00000358464.4_Missense_Mutation_p.E3Q																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGATGAGGGAACCTATATA	0.378000													22	632					0	0	0.847076	0	0
OR9A2	135924	broad.mit.edu	37	7	142724164	142724164	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142724164G>A	ENST00000350513.2	-	1	118	c.56C>T	c.(55-57)tCc>tTc	p.S19F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					TAGTCCTTGGGACCCAGGGAA	0.403000													27	36					0	0	0.779181	0	0
IMPG2	50939	broad.mit.edu	37	3	100951682	100951682	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:100951682T>C	ENST00000193391.7	-	15	3363	c.3176A>G	c.(3175-3177)gAc>gGc	p.D1059G		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1059	EGF-like 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CAAGCAGAAGTCAGGCTGTAG	0.483000													30	43					0	0	0.740014	0	0
SLC22A13	9390	broad.mit.edu	37	3	38318925	38318925	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:38318925G>T	ENST00000311856.4	+	10	1674	c.1625G>T	c.(1624-1626)gGa>gTa	p.G542V		NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	542						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TCCAGCCCGGGAGTGGCCTTT	0.557000													15	87					1.15088e-07	1.44013e-07	0.500413	1	0
COLEC12	81035	broad.mit.edu	37	18	335055	335055	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:335055A>T	ENST00000400256.3	-	6	1710	c.1503T>A	c.(1501-1503)tcT>tcA	p.S501S		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	501	Collagen-like 2.				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GGGAGCCTTTAGATCCTTTGC	0.692000													6	32					0	0	0.278610	0	0
ENPEP	2028	broad.mit.edu	37	4	111441168	111441168	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:111441168A>C	ENST00000265162.5	+	9	1856	c.1514A>C	c.(1513-1515)tAc>tCc	p.Y505S		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	505					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACACAGATGTACTTGGAAAAA	0.363000													7	24					0	0	0.278610	0	0
AGBL4	84871	broad.mit.edu	37	1	49511276	49511276	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:49511276C>A	ENST00000371839.1	-	5	690	c.574G>T	c.(574-576)Gag>Tag	p.E192*	AGBL4_ENST00000371838.1_Nonsense_Mutation_p.E192*|AGBL4_ENST00000371836.1_Nonsense_Mutation_p.E192*	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	192					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		CCCAGCTGCTCCCGAAAGAAG	0.453000													4	9					0.014758	0.0152943	0.184627	1	0
TBX5	6910	broad.mit.edu	37	12	114793472	114793472	+	Silent	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:114793472A>C	ENST00000310346.4	-	9	2088	c.1422T>G	c.(1420-1422)acT>acG	p.T474T	TBX5_ENST00000405440.2_Silent_p.T474T|TBX5_ENST00000349716.5_Silent_p.T424T	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	474					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		ACTGCAGGCCAGTCTGAGGCC	0.627000													13	29					0	0	0.435327	0	0
ADAM19	8728	broad.mit.edu	37	5	156934148	156934148	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:156934148C>A	ENST00000257527.4	-	10	984	c.905_splice	c.e10-1	p.T302_splice	ADAM19_ENST00000517905.1_Splice_Site_p.T302_splice|ADAM19_ENST00000430702.2_Splice_Site_p.T35_splice|ADAM19_ENST00000394020.1_Splice_Site_p.T304_splice	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	302	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGACATGCCCCTGCAGGAGG	0.627000													28	23					5.60225e-13	8.50277e-13	0.740014	1	0
PNPLA1	285848	broad.mit.edu	37	6	36275460	36275460	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:36275460G>T	ENST00000394571.2	+	8	1566	c.1566G>T	c.(1564-1566)tcG>tcT	p.S522S	PNPLA1_ENST00000312917.5_Silent_p.S436S|PNPLA1_ENST00000388715.3_Silent_p.S427S	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	522			S -> P (in dbSNP:rs4713956).		lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						CAAGACATTCGGGATCCAAAA	0.473000													27	23					8.16721e-17	1.36024e-16	0.750413	1	0
CNNM4	26504	broad.mit.edu	37	2	97428027	97428027	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:97428027G>C	ENST00000377075.2	+	1	1389	c.1291G>C	c.(1291-1293)Gac>Cac	p.D431H		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	431	CBS 1.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GGCCTTTGTGGACCCCGATGA	0.507000													58	214					0	0	0.870114	0	0
SLC38A6	145389	broad.mit.edu	37	14	61486288	61486288	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:61486288G>A	ENST00000354886.2	+	5	557	c.393G>A	c.(391-393)caG>caA	p.Q131Q	SLC38A6_ENST00000456840.2_Silent_p.Q108Q|SLC38A6_ENST00000267488.4_Silent_p.Q131Q	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	131					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TAATAATTCAGAATATTGGAG	0.333000													13	109					0	0	0.479597	0	0
RASEF	158158	broad.mit.edu	37	9	85619414	85619414	+	Splice_Site	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:85619414T>G	ENST00000376447.3	-	9	1461	c.1202_splice	c.e9+1	p.R401_splice		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	401					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TTAACATACCTGTCATAGCCT	0.333000													24	68					0	0	0.693898	0	0
ZMYM3	9203	broad.mit.edu	37	X	70463771	70463771	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:70463771C>A	ENST00000373998.1	-	21	4001	c.3304G>T	c.(3304-3306)Ggt>Tgt	p.G1102C	ZMYM3_ENST00000373988.1_Missense_Mutation_p.G1116C|ZMYM3_ENST00000314425.5_Missense_Mutation_p.G1114C|ZMYM3_ENST00000373984.3_Missense_Mutation_p.G1109C|ZMYM3_ENST00000353904.2_Missense_Mutation_p.G1114C|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1114					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TGGGCCAGACCGTAGTTGAGC	0.478000													50	36					1.67886e-27	3.31544e-27	0.870114	1	0
PTPRB	5787	broad.mit.edu	37	12	71003049	71003049	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:71003049G>C	ENST00000334414.6	-	4	823	c.779C>G	c.(778-780)tCt>tGt	p.S260C	PTPRB_ENST00000550358.1_Missense_Mutation_p.S260C|PTPRB_ENST00000551525.1_Missense_Mutation_p.S259C|PTPRB_ENST00000261266.5_Missense_Mutation_p.S42C|PTPRB_ENST00000451516.2_Missense_Mutation_p.S42C|PTPRB_ENST00000550857.1_Missense_Mutation_p.S42C|PTPRB_ENST00000538708.1_Missense_Mutation_p.S42C|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	42	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CCACTGGATAGACACAGAATG	0.527000													3	40					0	0	0.150653	0	0
ASTN1	460	broad.mit.edu	37	1	176838111	176838111	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:176838111C>A	ENST00000367654.2	-	22	3553	c.3540G>T	c.(3538-3540)gaG>gaT	p.E1180D	ASTN1_ENST00000424564.2_Missense_Mutation_p.E1172D|ASTN1_ENST00000361833.2_Missense_Mutation_p.E1172D|ASTN1_ENST00000367657.3_Missense_Mutation_p.E1172D			O14525	ASTN1_HUMAN	astrotactin 1	1180					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CGGTCTGCTGCTCCTTCCCAC	0.438000													19	82					0.00887093	0.00929571	0.575678	1	0
FAM135B	51059	broad.mit.edu	37	8	139163657	139163657	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:139163657T>A	ENST00000395297.1	-	13	3231	c.3061A>T	c.(3061-3063)Act>Tct	p.T1021S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1021										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGTCCAGAGTAAAGGTCTCT	0.527000										HNSCC(54;0.14)			21	22					0	0	0.667858	0	0
SETBP1	26040	broad.mit.edu	37	18	42531105	42531105	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:42531105G>A	ENST00000282030.5	+	4	2096	c.1800G>A	c.(1798-1800)acG>acA	p.T600T		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	600						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAGTCGAGACGATTCATGAGG	0.527000									Schinzel-Giedion syndrome				23	16					0	0	0.693898	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227300077	227300077	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:227300077C>A	ENST00000366769.3	-	14	3228	c.1937G>T	c.(1936-1938)aGg>aTg	p.R646M	CDC42BPA_ENST00000334218.5_Missense_Mutation_p.R646M|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.R646M|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.R646M|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.R646M|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.R565M|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.R646M	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	646					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ACGTAGCTTCCTGTCTTTAGA	0.363000													40	121					1.65492e-34	3.44149e-34	0.870114	1	0
SHANK1	50944	broad.mit.edu	37	19	51170166	51170166	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:51170166C>A	ENST00000293441.1	-	22	5069	c.5051G>T	c.(5050-5052)aGt>aTt	p.S1684I	SHANK1_ENST00000359082.3_Missense_Mutation_p.S1675I|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391814.1_Missense_Mutation_p.S1692I|SHANK1_ENST00000391813.1_Missense_Mutation_p.S1071I	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1684					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGGGTGGTCACTGCTGCTCCG	0.716000													4	5					3.59834e-05	4.08202e-05	0.217242	1	0
PLXNA3	55558	broad.mit.edu	37	X	153697502	153697502	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153697502C>T	ENST00000369682.3	+	26	4713	c.4538C>T	c.(4537-4539)aCt>aTt	p.T1513I	PLXNA3_ENST00000493546.1_3'UTR	NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1513					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCTGGACACTGTGTACAAG	0.597000													15	135					0	0	0.500413	0	0
CACNA1E	777	broad.mit.edu	37	1	181726102	181726102	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:181726102G>A	ENST00000526775.1	+	29	4277	c.4112G>A	c.(4111-4113)gGc>gAc	p.G1371D	CACNA1E_ENST00000357570.5_Missense_Mutation_p.G1341D|CACNA1E_ENST00000367567.4_Missense_Mutation_p.G997D|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G1371D|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G1390D|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G1322D|CACNA1E_ENST00000367570.1_Missense_Mutation_p.G1390D	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1390					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAAGACCGAGGCCCAAGCCGC	0.483000													15	173					0	0	0.539581	0	0
PKD2	5311	broad.mit.edu	37	4	88967893	88967893	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:88967893G>T	ENST00000237596.2	+	6	1485	c.1419G>T	c.(1417-1419)ctG>ctT	p.L473L	PKD2_ENST00000508588.1_Intron	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	473						basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ATTTCTTCCTGGCAGCCTGTG	0.383000													38	49					2.45108e-15	3.9259e-15	0.840704	1	0
UBE2J2	118424	broad.mit.edu	37	1	1190706	1190706	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:1190706G>C	ENST00000347370.2	-	7	974	c.501C>G	c.(499-501)ctC>ctG	p.L167L	UBE2J2_ENST00000360466.2_Silent_p.L219L|UBE2J2_ENST00000349431.6_Silent_p.L219L|UBE2J2_ENST00000400930.4_Silent_p.L235L|UBE2J2_ENST00000400929.2_Silent_p.L167L|UBE2J2_ENST00000339385.6_Silent_p.L184L|UBE2J2_ENST00000348298.7_Silent_p.L167L	NM_194458.1	NP_919440.1	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	219					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		TGGCCTGCTGGAGCCCTGCGA	0.632000													23	73					0	0	0.667858	0	0
CLDN10	9071	broad.mit.edu	37	13	96086270	96086270	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:96086270C>A	ENST00000376873.3	+	1	413	c.183C>A	c.(181-183)tgC>tgA	p.C61*		NM_001160100.1|NM_182848.3	NP_001153572.1|NP_878268.1	P78369	CLD10_HUMAN	claudin 10	63					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity	p.C61C(1)		endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			CTTTCCATTGCCGACCGCATT	0.493000													13	144					6.72482e-11	9.57346e-11	0.479597	1	0
HIST1H3G	8355	broad.mit.edu	37	6	26271399	26271399	+	Missense_Mutation	SNP	C	C	A	rs146261649	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:26271399C>A	ENST00000305910.3	-	1	213	c.214G>T	c.(214-216)Gtg>Ttg	p.V72L		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	72					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						ATTTCTCGCACCAGGCGTTGG	0.602000													72	60					3.48418e-26	6.78803e-26	0.870114	1	0
OR2G3	81469	broad.mit.edu	37	1	247768911	247768911	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:247768911C>A	ENST00000320002.2	+	1	56	c.24C>A	c.(22-24)tcC>tcA	p.S8S	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGAGAGTTCCCTAATGGATT	0.463000													24	54					1.80694e-10	2.53403e-10	0.740014	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905063	144905063	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:144905063C>A	ENST00000370490.1	+	1	5375	c.1120C>A	c.(1120-1122)Ccg>Acg	p.P374T	SLITRK2_ENST00000447897.2_Missense_Mutation_p.P374T|SLITRK2_ENST00000413937.2_Missense_Mutation_p.P374T|SLITRK2_ENST00000434188.2_Missense_Mutation_p.P374T|SLITRK2_ENST00000428560.2_Missense_Mutation_p.P374T			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	374						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					GCAGCCCAAACCGACCAGTCC	0.443000													8	30					5.18039e-06	6.09725e-06	0.278610	1	0
EIF2AK1	27102	broad.mit.edu	37	7	6098709	6098709	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:6098709C>A	ENST00000199389.6	-	1	152	c.6G>T	c.(4-6)caG>caT	p.Q2H	EIF2AK1_ENST00000536084.1_De_novo_Start_InFrame	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	2				Q -> L (in Ref. 3; AAF18391).	negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		AGTTGCCCCCCTGCATcgccg	0.761000													4	17					0.184627	0.18651	0.184627	1	0
RBFOX1	54715	broad.mit.edu	37	16	7760702	7760702	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:7760702G>T	ENST00000340209.4	+	13	1461	c.1164G>T	c.(1162-1164)caG>caT	p.Q388H	RBFOX1_ENST00000553186.1_Missense_Mutation_p.Q356H|RBFOX1_ENST00000552089.1_3'UTR|RBFOX1_ENST00000311745.5_Missense_Mutation_p.Q404H|RBFOX1_ENST00000355637.4_3'UTR|RBFOX1_ENST00000547372.1_3'UTR|RBFOX1_ENST00000436368.2_Splice_Site|RBFOX1_ENST00000550418.1_Missense_Mutation_p.Q383H|RBFOX1_ENST00000547338.1_Missense_Mutation_p.Q383H			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	383					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CTTCATTGCAGGCTAGTATAT	0.453000													40	75					5.34276e-22	9.90647e-22	0.870114	1	0
XIRP1	165904	broad.mit.edu	37	3	39226888	39226888	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:39226888G>T	ENST00000340369.3	-	2	4277	c.4049C>A	c.(4048-4050)cCc>cAc	p.P1350H	XIRP1_ENST00000396251.1_3'UTR|XIRP1_ENST00000421646.1_Missense_Mutation_p.P33H	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1350	Pro-rich.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGAAAAGCTGGGAGATAGAGG	0.592000													10	60					3.07112e-06	3.6397e-06	0.387290	1	0
RNF216	54476	broad.mit.edu	37	7	5754731	5754731	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:5754731C>G	ENST00000425013.2	-	11	1839	c.1615G>C	c.(1615-1617)Gag>Cag	p.E539Q	RNF216_ENST00000389902.3_Missense_Mutation_p.E596Q	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	539					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ATGAGACACTCTTTGCAGAAC	0.488000													165	235					0	0	0.870114	0	0
SYN1	6853	broad.mit.edu	37	X	47479030	47479030	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:47479030G>T	ENST00000295987.7	-	1	222	c.98C>A	c.(97-99)cCg>cAg	p.P33Q	SYN1_ENST00000340666.4_Missense_Mutation_p.P33Q	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	33	B; linker.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						ACCGGGCGGCGGTGGGGGCGG	0.721000													2	1					0.004672	0.00492037	0.115264	1	0
CAMTA2	23125	broad.mit.edu	37	17	4883439	4883439	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:4883439C>T	ENST00000361571.5	-	8	1586	c.1175G>A	c.(1174-1176)gGg>gAg	p.G392E	CAMTA2_ENST00000358183.4_Missense_Mutation_p.G393E|CAMTA2_ENST00000572543.1_Missense_Mutation_p.G398E|CAMTA2_ENST00000348066.3_Missense_Mutation_p.G393E|CAMTA2_ENST00000414043.3_Missense_Mutation_p.G416E|CAMTA2_ENST00000381311.5_Missense_Mutation_p.G395E	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	393					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TACTCCCTGCCCCCCTCCATA	0.647000													8	44					0	0	0.278610	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8660752	8660752	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:8660752G>T	ENST00000270328.4	-	11	1639	c.1373C>A	c.(1372-1374)cCc>cAc	p.P458H	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.P458H			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	458					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GTCCTGTCTGGGGGGCCGGTT	0.577000													151	61					8.57523e-64	1.92815e-63	0.870114	1	0
C6orf118	168090	broad.mit.edu	37	6	165715301	165715301	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:165715301T>C	ENST00000543069.1	-	2	779	c.198A>G	c.(196-198)ggA>ggG	p.G66G	C6orf118_ENST00000230301.8_Silent_p.G170G			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	170										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TCCTGCGCCATCCAGGAGGGC	0.612000													15	15					0	0	0.539581	0	0
MAP2	4133	broad.mit.edu	37	2	210561032	210561032	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:210561032G>T	ENST00000360351.4	+	7	4644	c.4138G>T	c.(4138-4140)Gac>Tac	p.D1380Y	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.D1376Y|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1380					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CACCATTGACGACTCCATCAT	0.418000													10	64					2.68362e-12	4.01796e-12	0.411799	1	0
FGFR2	2263	broad.mit.edu	37	10	123239428	123239428	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:123239428C>A	ENST00000358487.5	-	18	2681	c.2409G>T	c.(2407-2409)atG>atT	p.M803I	FGFR2_ENST00000346997.2_Missense_Mutation_p.M801I|FGFR2_ENST00000457416.2_Missense_Mutation_p.M804I|FGFR2_ENST00000369059.1_Missense_Mutation_p.M689I|FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369061.4_Missense_Mutation_p.M691I|FGFR2_ENST00000478859.1_Missense_Mutation_p.M575I|FGFR2_ENST00000369060.4_Missense_Mutation_p.M687I|FGFR2_ENST00000356226.4_Missense_Mutation_p.M686I	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	803					angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTTCGTAAGGCATGGGGTCTG	0.473000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				8	45					1.12685e-05	1.30266e-05	0.307466	1	0
TRIL	9865	broad.mit.edu	37	7	28997137	28997137	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:28997137C>A	ENST00000322982.3	-	0	797							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										CCCAAGGGAGCGAAGACCGCG	0.647000													7	20					1.58986e-06	1.90703e-06	0.361761	1	0
KMT2B	9757	broad.mit.edu	37	19	36212584	36212584	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:36212584G>T	ENST00000420124.1	+	3	2335	c.2335G>T	c.(2335-2337)Ggc>Tgc	p.G779C	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.G779C																							CCGGATTGCGGGCGTGGGTTC	0.607000													11	14					1.58986e-06	1.90703e-06	0.361761	1	0
SLC5A9	200010	broad.mit.edu	37	1	48699341	48699341	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:48699341G>T	ENST00000236495.5	+	10	1173	c.1123G>T	c.(1123-1125)Gtg>Ttg	p.V375L	SLC5A9_ENST00000420136.2_3'UTR|SLC5A9_ENST00000533824.1_Missense_Mutation_p.V371L|SLC5A9_ENST00000438567.2_Missense_Mutation_p.V350L	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	350						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GGTGGGCTGCGTGGACCCTGA	0.522000													13	35					2.32078e-09	3.13323e-09	0.479597	1	0
TNFSF11	8600	broad.mit.edu	37	13	43180817	43180817	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:43180817G>T	ENST00000398795.2	+	5	866	c.498G>T	c.(496-498)atG>atT	p.M166I	TNFSF11_ENST00000544862.1_Missense_Mutation_p.M166I|TNFSF11_ENST00000358545.2_Missense_Mutation_p.M166I|TNFSF11_ENST00000239849.6_Missense_Mutation_p.M239I|TNFSF11_ENST00000405262.2_Missense_Mutation_p.M166I	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	239					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTCAACTAATGGTGTACGTCA	0.388000													14	43					2.31682e-05	2.6474e-05	0.479597	1	0
INPP4B	8821	broad.mit.edu	37	4	143181714	143181714	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:143181714C>A	ENST00000513000.1	-	12	1052	c.619G>T	c.(619-621)Gcc>Tcc	p.A207S	INPP4B_ENST00000262992.4_Missense_Mutation_p.A207S|INPP4B_ENST00000508116.1_Missense_Mutation_p.A207S|INPP4B_ENST00000509777.1_Missense_Mutation_p.A207S|INPP4B_ENST00000308502.4_Missense_Mutation_p.A207S	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	207					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					CATACCAGGGCACACTAGGaa	0.303000													10	31					0.00136819	0.00146972	0.411799	1	0
MYBPC3	4607	broad.mit.edu	37	11	47363652	47363652	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:47363652G>A	ENST00000545968.1	-	18	1734	c.1680C>T	c.(1678-1680)gaC>gaT	p.D560D	MYBPC3_ENST00000399249.2_Silent_p.D560D|MYBPC3_ENST00000256993.4_Silent_p.D559D	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	559	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		ACACCGCCTGGTCCTTTGCGC	0.582000													11	26					0	0	0.387290	0	0
LOC150776	150776	broad.mit.edu	37	2	132275298	132275298	+	RNA	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:132275298A>T	ENST00000438378.2	+	0	1572					NR_026922.1																						CTTGGTCCCCAGGGCGCCCTT	0.627000													8	18					0	0	0.361761	0	0
SPTA1	6708	broad.mit.edu	37	1	158632626	158632626	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158632626G>A	ENST00000368148.3	-	17	2510	c.2330C>T	c.(2329-2331)gCt>gTt	p.A777V	SPTA1_ENST00000368147.3_Missense_Mutation_p.A777V	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	777					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.A777V(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTCTTTCAGAGCTTCAAATCG	0.473000													115	27					0	0	0.870114	0	0
SLC26A10	65012	broad.mit.edu	37	12	58019488	58019488	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:58019488C>A	ENST00000320442.4	+	14	1963	c.1652C>A	c.(1651-1653)aCc>aAc	p.T551N	SLC26A10_ENST00000490243.1_3'UTR|SLC26A10_ENST00000379218.2_3'UTR	NM_133489.2	NP_597996.2	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	551						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					GGCAGTAGCACCAGGAGCGGG	0.612000													21	58					5.45024e-15	8.69267e-15	0.654019	1	0
MS4A3	932	broad.mit.edu	37	11	59828637	59828637	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:59828637G>C	ENST00000278865.3	+	2	77	c.4G>C	c.(4-6)Gcc>Ccc	p.A2P	MS4A3_ENST00000526199.1_3'UTR|MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000534744.1_Missense_Mutation_p.A2P|MS4A3_ENST00000358152.2_Missense_Mutation_p.A2P	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	2						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				AACCCCAATGGCCTCCCACGA	0.478000													13	33					0	0	0.539581	0	0
LINC00202-2	731789	broad.mit.edu	37	10	26939617	26939617	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:26939617C>A	ENST00000544033.1	+	0	5550					NR_026794.1																						GCATACATTCCACCCAGCCGT	0.527000													7	11					8.12818e-05	9.07848e-05	0.248553	1	0
FAT3	120114	broad.mit.edu	37	11	92573857	92573857	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:92573857C>G	ENST00000298047.6	+	17	10515	c.10498C>G	c.(10498-10500)Cat>Gat	p.H3500D	FAT3_ENST00000409404.2_Missense_Mutation_p.H3500D|FAT3_ENST00000525166.1_Missense_Mutation_p.H3350D			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3500	Cadherin 32.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTTGGACCCTCATGGGATCTT	0.527000										TCGA Ovarian(4;0.039)			23	53					0	0	0.717897	0	0
ALKBH7	84266	broad.mit.edu	37	19	6374930	6374930	+	Silent	SNP	C	C	T	rs140036658		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:6374930C>T	ENST00000245812.3	+	4	1000	c.612C>T	c.(610-612)tcC>tcT	p.S204S	ALKBH7_ENST00000596657.1_Silent_p.S62S|ALKBH7_ENST00000599849.1_Silent_p.S143S	NM_032306.3	NP_115682.1	Q9BT30	ALKB7_HUMAN	alkB, alkylation repair homolog 7 (E. coli)	204						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						TCTGCCGCTCCCTCCCTGAGG	0.607000													53	27					0	0	0.870114	0	0
TRPM5	29850	broad.mit.edu	37	11	2433484	2433484	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:2433484C>A	ENST00000452833.1	-	16	2370		c.e16-1		TRPM5_ENST00000155858.6_Splice_Site|TRPM5_ENST00000533060.1_Splice_Site|TRPM5_ENST00000528453.1_Splice_Site			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5							integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAAGAAGCCCTGGGAGGGAG	0.567000													96	96					4.10022e-50	9.08905e-50	0.870114	1	0
FRMD3	257019	broad.mit.edu	37	9	85914069	85914069	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:85914069G>C	ENST00000304195.3	-	11	1165	c.959C>G	c.(958-960)tCa>tGa	p.S320*	FRMD3_ENST00000376434.1_Nonsense_Mutation_p.S126*|FRMD3_ENST00000376438.1_Nonsense_Mutation_p.S320*	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	320						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CTTGCTGCTTGATACAGTCTT	0.408000													8	29					0	0	0.387290	0	0
TENM1	10178	broad.mit.edu	37	X	123540185	123540185	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123540185T>C	ENST00000422452.2	-	26	5200	c.5137A>G	c.(5137-5139)Ata>Gta	p.I1713V	TENM1_ENST00000371130.3_Missense_Mutation_p.I1706V|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		AAAATATATATGGTACTAGTT	0.418000													13	71					0	0	0.520397	0	0
WNT8B	7479	broad.mit.edu	37	10	102242111	102242111	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:102242111G>A	ENST00000343737.5	+	6	722	c.594G>A	c.(592-594)ctG>ctA	p.L198L		NM_003393.3	NP_003384.2	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family, member 8B	198					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		GGCTGCAGCTGCCCGAGTTCC	0.672000											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	12					0	0	0.115264	0	0
AZGP1	563	broad.mit.edu	37	7	99564902	99564902	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:99564902G>T	ENST00000292401.4	-	4	757	c.621C>A	c.(619-621)ccC>ccA	p.P207P	AZGP1_ENST00000411734.1_3'UTR|AZGP1_ENST00000483612.1_5'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	207	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCACCACAGAGGGAGGATCTG	0.572000													8	34					0.00621372	0.00653308	0.335167	1	0
PHACTR3	116154	broad.mit.edu	37	20	58349461	58349461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:58349461G>T	ENST00000371015.1	+	7	1557	c.1090G>T	c.(1090-1092)Gag>Tag	p.E364*	PHACTR3_ENST00000359926.3_Nonsense_Mutation_p.E361*|PHACTR3_ENST00000361300.4_Nonsense_Mutation_p.E253*|PHACTR3_ENST00000395639.4_Nonsense_Mutation_p.E253*|PHACTR3_ENST00000541461.1_Nonsense_Mutation_p.E323*|PHACTR3_ENST00000355648.4_Nonsense_Mutation_p.E323*|PHACTR3_ENST00000395636.2_Nonsense_Mutation_p.E323*	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	364						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GGAGAACAAGGAGAACCTGAT	0.522000													33	56					6.97489e-18	1.19551e-17	0.804634	1	0
NCAN	1463	broad.mit.edu	37	19	19349180	19349180	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:19349180G>T	ENST00000252575.5	+	11	3412	c.3369G>T	c.(3367-3369)ctG>ctT	p.L1123L	NCAN_ENST00000538881.1_Silent_p.L574L	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1123	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CCGGCCACCTGACCAGCGTCC	0.642000													67	25					8.27458e-37	1.75369e-36	0.870114	1	0
JSRP1	126306	broad.mit.edu	37	19	2252606	2252606	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:2252606G>C	ENST00000300961.5	-	7	782	c.718C>G	c.(718-720)Cgg>Ggg	p.R240G	JSRP1_ENST00000586471.1_Missense_Mutation_p.R240G	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	240	Arg-rich.					sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTCTCTCCGAGGCCTCTCC	0.692000													30	76					0	0	0.796494	0	0
DPPA5	340168	broad.mit.edu	37	6	74063703	74063703	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:74063703G>T	ENST00000370370.3	-	2	234	c.165C>A	c.(163-165)ctC>ctA	p.L55L		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	55	KH; atypical.				multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						CCTTCAGCTCGAGCATGGCCT	0.587000													12	148					1.5739e-10	2.22045e-10	0.500413	1	0
DPY19L4	286148	broad.mit.edu	37	8	95782726	95782726	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:95782726G>C	ENST00000414645.2	+	13	1480	c.1381G>C	c.(1381-1383)Gga>Cga	p.G461R		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	461						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TGGACGAATTGGAGAAAGACC	0.308000													24	42					0	0	0.681144	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185404921	185404921	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:185404921C>T	ENST00000382199.2	-	7	831	c.736G>A	c.(736-738)Gcc>Acc	p.A246T	IGF2BP2_ENST00000494906.1_5'UTR|IGF2BP2_ENST00000346192.3_Missense_Mutation_p.A246T|IGF2BP2_ENST00000457616.2_Missense_Mutation_p.A252T|IGF2BP2_ENST00000421047.2_Missense_Mutation_p.A189T	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	246	KH 1.				anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TCTGGGGTGGCATGGATGGTG	0.473000													43	77					0	0	0.870114	0	0
OR4M1	441670	broad.mit.edu	37	14	20249159	20249159	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:20249159G>A	ENST00000315957.4	+	1	759	c.678G>A	c.(676-678)aaG>aaA	p.K226K		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTTGCTCAAGAAACATTCAG	0.463000													72	341					0	0	0.870114	0	0
CHD3	1107	broad.mit.edu	37	17	7802665	7802665	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:7802665A>C	ENST00000380358.4	+	15	2526	c.2525A>C	c.(2524-2526)cAc>cCc	p.H842P	CHD3_ENST00000330494.7_Missense_Mutation_p.H783P|CHD3_ENST00000358181.4_Missense_Mutation_p.H783P	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	783	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TCCCAGGGCCACACAAAAGGT	0.547000													102	49					0	0	0.870114	0	0
OVOS2	144203	broad.mit.edu	37	12	31269326	31269326	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:31269326G>A	ENST00000542490.1	-	0	129																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CAGTCAAAGAGTAGTTCTTTA	0.353000													32	32					0	0	0.834066	0	0
MYOD1	4654	broad.mit.edu	37	11	17742857	17742857	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:17742857C>T	ENST00000250003.3	+	3	980	c.765C>T	c.(763-765)atC>atT	p.I255I		NM_002478.4	NP_002469.2	P15172	MYOD1_HUMAN	myogenic differentiation 1	255					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	17						TGTCCAGCATCGTGGAGCGCA	0.716000													5	9					0	0	0.217242	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31104526	31104526	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:31104526T>G	ENST00000304166.4	+	3	420	c.131T>G	c.(130-132)cTg>cGg	p.L44R	ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.L44R|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.L44R|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.L44R	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	44					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GCCAATGAGCTGATGGGCTTC	0.567000													17	19					0	0	0.575678	0	0
REG3A	5068	broad.mit.edu	37	2	79385466	79385466	+	Missense_Mutation	SNP	G	G	A	rs11554092		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:79385466G>A	ENST00000393878.1	-	3	573	c.319C>T	c.(319-321)Cat>Tat	p.H107Y	REG3A_ENST00000409839.3_Missense_Mutation_p.H107Y|REG3A_ENST00000305165.2_Missense_Mutation_p.H107Y	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	107	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						GTGGGGTCATGGAGCCCAATC	0.572000													18	40					0	0	0.608945	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125879714	125879714	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:125879714C>A	ENST00000393434.2	-	2	458	c.109G>T	c.(109-111)Gga>Tga	p.G37*	ALDH1L1_ENST00000472186.1_Nonsense_Mutation_p.G37*|ALDH1L1_ENST00000393431.2_Nonsense_Mutation_p.G37*|ALDH1L1_ENST00000455064.2_5'UTR|ALDH1L1_ENST00000273450.3_Nonsense_Mutation_p.G47*|ALDH1L1_ENST00000452905.2_Nonsense_Mutation_p.G37*	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	37	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCGGCCTTTCCATCCTTGTCT	0.592000													62	28					5.41189e-41	1.16669e-40	0.870114	1	0
SHOX	6473	broad.mit.edu	37	X	591766	591766	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:591766G>T	ENST00000381578.1	+	2	825	c.134G>T	c.(133-135)cGc>cTc	p.R45L	SHOX_ENST00000334060.3_Missense_Mutation_p.R45L|SHOX_ENST00000381575.1_Missense_Mutation_p.R45L|SHOX_ENST00000554971.1_Missense_Mutation_p.R45L	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	45					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGACTGGCGCGCTCCCGGGAG	0.612000													16	50					7.07596e-05	7.95993e-05	0.539581	1	0
LPPR5	163404	broad.mit.edu	37	1	99470168	99470168	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:99470168C>T	ENST00000370188.3	-	1	420	c.60G>A	c.(58-60)atG>atA	p.M20I	RP5-896L10.1_ENST00000425113.1_RNA|LPPR5_ENST00000263177.4_Missense_Mutation_p.M20I	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		20						integral to membrane	hydrolase activity										CCGTCCCTGCCATGATCACCA	0.652000													38	77					0	0	0.870114	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325218	79325218	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:79325218C>A	ENST00000428286.1	-	8	2095	c.895G>T	c.(895-897)Ggt>Tgt	p.G299C	PRUNE2_ENST00000376718.3_Missense_Mutation_p.G658C			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	658					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCCAAACCACCCCACCAGCTG	0.493000													23	85					5.60225e-13	8.50277e-13	0.740014	1	0
MLLT6	4302	broad.mit.edu	37	17	36868121	36868121	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:36868121G>T	ENST00000325718.7	+	7	665	c.574G>T	c.(574-576)Ggg>Tgg	p.G192W	MLLT6_ENST00000378137.5_Missense_Mutation_p.G192W	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	192	Gly/Ser-rich.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					GCACAGCAGCGGGGGAGGCGG	0.602000			T	MLL	AL								3	10					0.00024832	0.000273297	0.150653	1	0
CACNB4	785	broad.mit.edu	37	2	152727095	152727095	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:152727095G>A	ENST00000360283.6	-	7	807	c.550C>T	c.(550-552)Ccg>Tcg	p.P184S	CACNB4_ENST00000539935.1_Missense_Mutation_p.P217S|CACNB4_ENST00000201943.5_Missense_Mutation_p.P217S|CACNB4_ENST00000427385.1_Missense_Mutation_p.P199S|CACNB4_ENST00000397327.2_Missense_Mutation_p.P170S|CACNB4_ENST00000534999.1_Missense_Mutation_p.P183S			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	217					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	CGCATTGACGGTACAACATCG	0.493000													5	21					0	0	0.278610	0	0
PTPRD	5789	broad.mit.edu	37	9	8341975	8341975	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:8341975C>A	ENST00000381196.4	-	37	5208	c.4665G>T	c.(4663-4665)gcG>gcT	p.A1555A	PTPRD_ENST00000540109.1_Silent_p.A1555A|PTPRD_ENST00000358503.5_Silent_p.A1533A|PTPRD_ENST00000537002.1_Silent_p.A1145A|PTPRD_ENST00000356435.5_Silent_p.A1555A|PTPRD_ENST00000486161.1_Silent_p.A1148A|PTPRD_ENST00000360074.4_Silent_p.A1542A|PTPRD_ENST00000397606.3_Silent_p.A1148A|PTPRD_ENST00000397617.3_Silent_p.A1148A|PTPRD_ENST00000355233.5_Silent_p.A1149A|PTPRD_ENST00000397611.3_Silent_p.A1145A	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1555	Substrate binding (By similarity).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGCCAACTCCCGCACTATGAG	0.323000										TSP Lung(15;0.13)			11	32					1.49906e-05	1.72026e-05	0.457914	1	0
HPSE	10855	broad.mit.edu	37	4	84255881	84255881	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:84255881C>T	ENST00000405413.2	-	2	191	c.55G>A	c.(55-57)Ggg>Agg	p.G19R	HPSE_ENST00000512196.1_Missense_Mutation_p.G19R|HPSE_ENST00000311412.5_Missense_Mutation_p.G19R|HPSE_ENST00000513463.1_Missense_Mutation_p.G19R	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	19					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CCCAGCGGCCCCAGGAGCAGC	0.721000													3	0					0	0	0.150653	0	0
C10orf54	64115	broad.mit.edu	37	10	73515128	73515128	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:73515128C>T	ENST00000394957.3	-	4	722	c.664G>A	c.(664-666)Gcc>Acc	p.A222T	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	222						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CGGTTGGAGGCTGCCTGCCTT	0.632000													7	11					0	0	0.278610	0	0
POGZ	23126	broad.mit.edu	37	1	151381005	151381005	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:151381005T>C	ENST00000271715.2	-	14	2428	c.2114A>G	c.(2113-2115)aAt>aGt	p.N705S	POGZ_ENST00000540984.1_Missense_Mutation_p.N67S|POGZ_ENST00000409503.1_Missense_Mutation_p.N696S|POGZ_ENST00000531094.1_Missense_Mutation_p.N643S|POGZ_ENST00000392723.1_Missense_Mutation_p.N652S|POGZ_ENST00000491586.1_Missense_Mutation_p.N661S|POGZ_ENST00000368863.2_Missense_Mutation_p.N610S|POGZ_ENST00000361398.3_Missense_Mutation_p.N652S	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	705					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTGTATCATTAGAGGATAC	0.552000													54	140					0	0	0.870114	0	0
CACNA1E	777	broad.mit.edu	37	1	181689448	181689448	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:181689448C>T	ENST00000526775.1	+	14	2023	c.1858C>T	c.(1858-1860)Cta>Tta	p.L620L	CACNA1E_ENST00000357570.5_Silent_p.L571L|CACNA1E_ENST00000367567.4_Silent_p.L227L|CACNA1E_ENST00000360108.3_Silent_p.L620L|CACNA1E_ENST00000367573.2_Silent_p.L620L|CACNA1E_ENST00000358338.5_Silent_p.L571L|CACNA1E_ENST00000367570.1_Silent_p.L620L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	620					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTTGCTCTCCTAGGAATGCA	0.478000													4	14					0	0	0.150653	0	0
RANBP6	26953	broad.mit.edu	37	9	6014811	6014811	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:6014811G>A	ENST00000259569.5	-	1	807	c.797C>T	c.(796-798)aCt>aTt	p.T266I	RANBP6_ENST00000485372.1_Intron	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	266					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		CAACTGTAGAGTATCTTCTAA	0.443000													16	75					0	0	0.479597	0	0
COL14A1	7373	broad.mit.edu	37	8	121174765	121174765	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:121174765C>T	ENST00000297848.3	+	4	576	c.306C>T	c.(304-306)taC>taT	p.Y102Y	COL14A1_ENST00000309791.4_Silent_p.Y102Y|COL14A1_ENST00000247781.3_Silent_p.Y102Y|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000537875.1_Silent_p.Y102Y	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	102	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTATTGCATACAATAAAGATA	0.413000													5	59					0	0	0.184627	0	0
DOCK2	1794	broad.mit.edu	37	5	169474605	169474605	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:169474605C>A	ENST00000256935.8	+	40	4138	c.4058C>A	c.(4057-4059)cCc>cAc	p.P1353H	DOCK2_ENST00000540750.1_Missense_Mutation_p.P414H|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.P845H	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1353	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGGATTCCCCTCCTTCCTG	0.527000													19	19					1.55469e-16	2.57338e-16	0.654019	1	0
FBXO24	26261	broad.mit.edu	37	7	100190515	100190515	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100190515G>A	ENST00000241071.6	+	5	990	c.668G>A	c.(667-669)tGt>tAt	p.C223Y	PCOLCE-AS1_ENST00000544873.1_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.C261Y|FBXO24_ENST00000468962.1_Missense_Mutation_p.C211Y|FBXO24_ENST00000465843.1_Missense_Mutation_p.C209Y|FBXO24_ENST00000360609.2_Missense_Mutation_p.C209Y|PCOLCE-AS1_ENST00000442166.2_RNA	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	223						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GCCTGTGACTGTGTTGAGGTC	0.557000													12	78					0	0	0.435327	0	0
TOX2	84969	broad.mit.edu	37	20	42694471	42694471	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:42694471C>A	ENST00000358131.5	+	6	1234	c.1026C>A	c.(1024-1026)gaC>gaA	p.D342E	TOX2_ENST00000423191.1_Missense_Mutation_p.D318E|TOX2_ENST00000435864.2_Missense_Mutation_p.D238E|TOX2_ENST00000341197.3_Missense_Mutation_p.D360E|TOX2_ENST00000372999.1_Missense_Mutation_p.D318E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CGCCGTCGGACCTGCAGGCCT	0.682000													38	101					6.2361e-21	1.13835e-20	0.834066	1	0
TG	7038	broad.mit.edu	37	8	134042224	134042224	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:134042224G>C	ENST00000220616.4	+	41	7235	c.7195G>C	c.(7195-7197)Gcc>Ccc	p.A2399P	TG_ENST00000542445.1_Missense_Mutation_p.A769P|TG_ENST00000377869.1_Missense_Mutation_p.A2342P|TG_ENST00000519543.1_Missense_Mutation_p.A532P	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2399					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTTCTCACGGCCAGGGCCAC	0.627000													43	95					0	0	0.870114	0	0
POU5F1	5460	broad.mit.edu	37	6	31132966	31132966	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:31132966C>A	ENST00000513407.1	-	2	1697	c.167G>T	c.(166-168)tGc>tTc	p.C56F	POU5F1_ENST00000471529.2_Missense_Mutation_p.C56F|POU5F1_ENST00000512818.1_Missense_Mutation_p.C56F|POU5F1_ENST00000441888.3_Missense_Mutation_p.C56F|POU5F1_ENST00000606567.1_Missense_Mutation_p.C82F|POU5F1_ENST00000259915.8_Missense_Mutation_p.C252F			Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	252					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						GGGTTTCGGGCACTGCAGGAA	0.557000			T	EWSR1	sarcoma								6	13					3.07112e-06	3.6397e-06	0.387290	1	0
LRRK1	79705	broad.mit.edu	37	15	101552290	101552290	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:101552290G>T	ENST00000284395.5	+	11	1750	c.1350G>T	c.(1348-1350)aaG>aaT	p.K450N	LRRK1_ENST00000388948.3_Missense_Mutation_p.K453N			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	453					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCACCTGAAGGATGTGGATT	0.408000													21	60					1.42536e-11	2.07465e-11	0.681144	1	0
IL12RB2	3595	broad.mit.edu	37	1	67816615	67816615	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:67816615G>C	ENST00000262345.1	+	9	1741	c.1101G>C	c.(1099-1101)ctG>ctC	p.L367L	IL12RB2_ENST00000371000.1_Silent_p.L367L|IL12RB2_ENST00000541374.1_Silent_p.L367L|IL12RB2_ENST00000544434.1_Silent_p.L367L	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	367	Fibronectin type-III 3.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						TGCAGGAGCTGACAGGAGGGA	0.483000													12	75					0	0	0.411799	0	0
XIAP	331	broad.mit.edu	37	X	123019761	123019761	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123019761C>A	ENST00000371199.3	+	2	548	c.249C>A	c.(247-249)caC>caA	p.H83Q	XIAP_ENST00000355640.3_Missense_Mutation_p.H83Q|XIAP_ENST00000434753.3_Missense_Mutation_p.H83Q|XIAP_ENST00000468691.1_Intron	NM_001167.3	NP_001158.2	P98170	XIAP_HUMAN	X-linked inhibitor of apoptosis	83					anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)	25						TTGGAAGACACAGGAAAGTAT	0.428000									X-linked Lymphoproliferative syndrome				13	67					0.000566183	0.00061915	0.520397	1	0
OVCH1	341350	broad.mit.edu	37	12	29598264	29598264	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:29598264T>A	ENST00000318184.5	-	23	2827	c.2828A>T	c.(2827-2829)cAt>cTt	p.H943L	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	943	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TACAAGGGCATGGAATGTCAC	0.373000													13	25					0	0	0.500413	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12952827	12952827	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:12952827T>A	ENST00000235347.4	-	4	1424	c.1345A>T	c.(1345-1347)Agg>Tgg	p.R449W		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	449										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGAAGATCCTCTTGGGCTGC	0.542000													24	50					0	0	0.796494	0	0
SATB2	23314	broad.mit.edu	37	2	200137217	200137217	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:200137217G>A	ENST00000443023.1	-	10	3207	c.1742C>T	c.(1741-1743)cCa>cTa	p.P581L	SATB2_ENST00000260926.5_Missense_Mutation_p.P640L|SATB2_ENST00000428695.1_Missense_Mutation_p.P522L|SATB2_ENST00000457245.1_Missense_Mutation_p.P640L|SATB2_ENST00000417098.1_Missense_Mutation_p.P640L			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	640						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTCCTGGTCTGGGTACAGGCC	0.522000													6	40					0	0	0.217242	0	0
GCN1L1	10985	broad.mit.edu	37	12	120568462	120568462	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:120568462G>T	ENST00000300648.6	-	56	7671	c.7659C>A	c.(7657-7659)agC>agA	p.S2553R		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2553					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAACGAACAGGCTGGAAAGTT	0.592000													6	93					3.09899e-07	3.82696e-07	0.307466	1	0
ZNF536	9745	broad.mit.edu	37	19	31038958	31038958	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:31038958C>A	ENST00000355537.3	+	4	2579	c.2432C>A	c.(2431-2433)cCg>cAg	p.P811Q		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGGGCTGGGCCGCTGTCTGGG	0.567000													114	24					1.83374e-54	4.0745e-54	0.870114	1	0
MAP1A	4130	broad.mit.edu	37	15	43813880	43813880	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:43813880C>A	ENST00000382031.1	+	5	954	c.923C>A	c.(922-924)tCc>tAc	p.S308Y	MAP1A_ENST00000300231.5_Missense_Mutation_p.S70Y|MAP1A_ENST00000399453.1_Missense_Mutation_p.S70Y			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	70						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GATCGCAAGTCCTGTTTTTGG	0.537000													17	30					3.32936e-07	4.09265e-07	0.539581	1	0
CXADRP3	440224	broad.mit.edu	37	18	14479237	14479237	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:14479237C>A	ENST00000581457.1	-	0	671					NR_024076.1																						CGACTCCGCACAGGAGCACGA	0.587000													6	7					3.59834e-05	4.08202e-05	0.217242	1	0
PHF12	57649	broad.mit.edu	37	17	27251142	27251142	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:27251142G>A	ENST00000577226.1	-	4	846	c.500C>T	c.(499-501)cCc>cTc	p.P167L	PHF12_ENST00000332830.4_Missense_Mutation_p.P167L|PHF12_ENST00000268756.3_Missense_Mutation_p.P167L|PHF12_ENST00000582655.1_5'UTR			Q96QT6	PHF12_HUMAN	PHD finger protein 12	167	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			GCTGGATGTGGGTGTGCCAGG	0.562000													10	30					0	0	0.387290	0	0
GJD4	219770	broad.mit.edu	37	10	35896753	35896753	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:35896753C>A	ENST00000321660.1	+	2	470	c.312C>A	c.(310-312)gcC>gcA	p.A104A		NM_153368.2	NP_699199.2	Q96KN9	CXD4_HUMAN	gap junction protein, delta 4, 40.1kDa	104					cell communication	connexon complex|integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						CCACGCTCGCCGCGCTGGGCC	0.756000													16	34					3.8784e-16	6.35262e-16	0.608945	1	0
STK31	56164	broad.mit.edu	37	7	23823238	23823238	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:23823238G>T	ENST00000354639.3	+	17	2499	c.2035G>T	c.(2035-2037)Gag>Tag	p.E679*	STK31_ENST00000355870.3_Nonsense_Mutation_p.E702*|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Nonsense_Mutation_p.E679*|STK31_ENST00000433467.2_Nonsense_Mutation_p.E702*	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	702							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ATGGTTCCCTGAGCTGCCTCT	0.343000													40	89					4.96213e-28	9.85099e-28	0.870114	1	0
CYFIP1	23191	broad.mit.edu	37	15	22933657	22933657	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:22933657G>T	ENST00000313077.7	+	7	791	c.666_splice	c.e7+1	p.Q222_splice	CYFIP1_ENST00000560848.1_Splice_Site_p.Q222_splice	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	222					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		AGATCACACAGGTAAGGCTGG	0.537000													26	25					7.38237e-10	1.00898e-09	0.706142	1	0
SERPINA1	5265	broad.mit.edu	37	14	94848956	94848956	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:94848956C>A	ENST00000448921.1	-	4	1191	c.619G>T	c.(619-621)Gct>Tct	p.A207S	SERPINA1_ENST00000402629.1_Missense_Mutation_p.A207S|SERPINA1_ENST00000440909.1_Missense_Mutation_p.A207S|SERPINA1_ENST00000449399.3_Missense_Mutation_p.A207S|SERPINA1_ENST00000393088.4_Missense_Mutation_p.A207S|SERPINA1_ENST00000404814.4_Missense_Mutation_p.A207S|SERPINA1_ENST00000393087.4_Missense_Mutation_p.A207S|SERPINA1_ENST00000437397.1_Missense_Mutation_p.A207S|SERPINA1_ENST00000355814.4_Missense_Mutation_p.A207S	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	207					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TTCACCAGAGCAAAAACTGTG	0.423000													41	82					4.01344e-20	7.22803e-20	0.870114	1	0
RYR2	6262	broad.mit.edu	37	1	237670104	237670104	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237670104A>T	ENST00000366574.2	+	23	3025	c.2708A>T	c.(2707-2709)cAg>cTg	p.Q903L	RYR2_ENST00000542537.1_Missense_Mutation_p.Q887L|RYR2_ENST00000360064.6_Missense_Mutation_p.Q901L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	903	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTGGCTGGCAGTATGGTCCG	0.368000													5	20					0	0	0.248553	0	0
TIE1	7075	broad.mit.edu	37	1	43778833	43778833	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:43778833C>G	ENST00000372476.3	+	13	2034	c.1955C>G	c.(1954-1956)gCc>gGc	p.A652G	TIE1_ENST00000433781.2_Missense_Mutation_p.A297G	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	652	Fibronectin type-III 3.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CACCTCCACGCCCAGGCCCTC	0.642000													15	42					0	0	0.592651	0	0
IFLTD1	160492	broad.mit.edu	37	12	25702426	25702426	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:25702426C>G	ENST00000282881.6	-	2	230	c.81G>C	c.(79-81)ttG>ttC	p.L27F	IFLTD1_ENST00000413632.2_Missense_Mutation_p.L48F|IFLTD1_ENST00000445693.1_Intron|IFLTD1_ENST00000539744.1_5'UTR|IFLTD1_ENST00000458174.2_Missense_Mutation_p.L48F	NM_152590.3	NP_689803.2	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	27						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					CAACTGAACCCAACATCTTTG	0.323000													21	67					0	0	0.624587	0	0
HMCN1	83872	broad.mit.edu	37	1	186086648	186086648	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:186086648C>G	ENST00000271588.4	+	77	11970	c.11741C>G	c.(11740-11742)gCa>gGa	p.A3914G	HMCN1_ENST00000367492.2_Missense_Mutation_p.A3914G	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3914	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CATGCCCCAGCAGTAATTACC	0.423000													16	71					0	0	0.624587	0	0
MCF2	4168	broad.mit.edu	37	X	138689896	138689896	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:138689896G>T	ENST00000520602.1	-	15	1909	c.1624C>A	c.(1624-1626)Cca>Aca	p.P542T	MCF2_ENST00000414978.1_Missense_Mutation_p.P542T|MCF2_ENST00000370573.4_Missense_Mutation_p.P482T|MCF2_ENST00000370576.4_Missense_Mutation_p.P482T|MCF2_ENST00000483690.1_5'UTR|MCF2_ENST00000536274.1_Missense_Mutation_p.P443T|MCF2_ENST00000370578.4_Missense_Mutation_p.P627T|MCF2_ENST00000519895.1_Missense_Mutation_p.P558T|MCF2_ENST00000338585.6_Missense_Mutation_p.P498T			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	482	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					CTGGAGGATGGACCAGAACTT	0.348000													17	56					9.86323e-18	1.68139e-17	0.667858	1	0
ITCH	83737	broad.mit.edu	37	20	33065588	33065588	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:33065588C>A	ENST00000374864.4	+	17	1794	c.1581C>A	c.(1579-1581)ttC>ttA	p.F527L	ITCH_ENST00000535650.1_Missense_Mutation_p.F417L|ITCH_ENST00000262650.6_Missense_Mutation_p.F568L|ITCH_ENST00000483727.1_3'UTR	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	568					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						TAATGAGCTTCAGTCCCCAAG	0.363000													6	93					8.12818e-05	9.07848e-05	0.248553	1	0
ATM	472	broad.mit.edu	37	11	108143448	108143448	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:108143448G>T	ENST00000278616.4	+	22	3538		c.e22-1		ATM_ENST00000452508.2_Splice_Site	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTTTCCCGTAGGCTGATCCTT	0.308000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			8	21					0.000157383	0.000174438	0.278610	1	0
GHR	2690	broad.mit.edu	37	5	42711463	42711463	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:42711463C>A	ENST00000230882.4	+	7	963	c.773C>A	c.(772-774)aCa>aAa	p.T258K	GHR_ENST00000357703.3_Missense_Mutation_p.T236K|GHR_ENST00000537449.1_Missense_Mutation_p.T71K	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	258					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGCCAATTTACATGTGAAGAA	0.393000													14	36					6.94344e-10	9.5106e-10	0.539581	1	0
RFC2	5982	broad.mit.edu	37	7	73649961	73649961	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:73649961C>A	ENST00000055077.3	-	10	915	c.855G>T	c.(853-855)ttG>ttT	p.L285F	RFC2_ENST00000352131.3_Missense_Mutation_p.L251F	NM_181471.1	NP_852136.1	P35250	RFC2_HUMAN	replication factor C (activator 1) 2, 40kDa	285					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)	8						CCAGATGCCACAAGTGAGCAA	0.433000													76	116					6.01781e-45	1.31692e-44	0.870114	1	0
COL3A1	1281	broad.mit.edu	37	2	189870086	189870086	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:189870086G>A	ENST00000304636.3	+	41	3112	c.2942G>A	c.(2941-2943)gGg>gAg	p.G981E	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	981	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTGAAAGTGGGAAACCAGGA	0.428000													31	76					0	0	0.834066	0	0
PRRX1	5396	broad.mit.edu	37	1	170695528	170695528	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:170695528A>G	ENST00000239461.6	+	3	898	c.585A>G	c.(583-585)acA>acG	p.T195T	PRRX1_ENST00000367760.3_Silent_p.T195T|PRRX1_ENST00000497230.2_Silent_p.T195T|PRRX1_ENST00000476867.2_3'UTR	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	195						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCTGGGGGACAGCGTCTCCGT	0.572000													25	106					0	0	0.779181	0	0
P2RX7	5027	broad.mit.edu	37	12	121603861	121603861	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:121603861G>C	ENST00000328963.5	+	6	559	c.104_splice	c.e6-1	p.T35_splice	P2RX7_ENST00000377162.2_Intron|P2RX7_ENST00000546057.1_Splice_Site_p.T205_splice|P2RX7_ENST00000541446.1_5'UTR|P2RX7_ENST00000535250.1_Splice_Site_p.T115_splice|P2RX7_ENST00000443520.3_3'UTR			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	205						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTATGCACAGGAGAAACATCC	0.438000													22	69					0	0	0.639603	0	0
RTEL1	51750	broad.mit.edu	37	20	62316902	62316902	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:62316902G>T	ENST00000318100.4	+	15	2045	c.1218G>T	c.(1216-1218)gaG>gaT	p.E406D	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.E406D|RTEL1_ENST00000360203.5_Missense_Mutation_p.E406D|RTEL1_ENST00000370018.3_Missense_Mutation_p.E406D|RTEL1_ENST00000508582.2_Missense_Mutation_p.E430D			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	406					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			ACCCCTCCGAGGGCAGCCCTG	0.637000													9	17					2.68362e-12	4.01796e-12	0.411799	1	0
RIMS2	9699	broad.mit.edu	37	8	104955027	104955027	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:104955027A>G	ENST00000507740.1	+	11	2186	c.1950A>G	c.(1948-1950)ttA>ttG	p.L650L	RIMS2_ENST00000436393.2_Silent_p.L636L|RIMS2_ENST00000262231.10_Silent_p.L697L|RIMS2_ENST00000406091.3_Silent_p.L858L	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	920					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAACAGCATTATTAGATGATG	0.368000										HNSCC(12;0.0054)			25	31					0	0	0.717897	0	0
ZNF536	9745	broad.mit.edu	37	19	31039829	31039829	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:31039829C>A	ENST00000355537.3	+	4	3450	c.3303C>A	c.(3301-3303)gaC>gaA	p.D1101E		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCCACGTGGACCCTGCATTTT	0.552000													60	23					5.61366e-43	1.22279e-42	0.870114	1	0
C6orf211	79624	broad.mit.edu	37	6	151789865	151789865	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:151789865G>T	ENST00000367294.3	+	5	1205	c.946G>T	c.(946-948)Ggg>Tgg	p.G316W	C6orf211_ENST00000545879.1_Missense_Mutation_p.G197W	NM_024573.1	NP_078849.1	Q9H993	CF211_HUMAN	chromosome 6 open reading frame 211	316							protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(7)	15			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		GTCCAAGTGTGGGGCTGACTG	0.368000													15	54					3.51602e-12	5.24754e-12	0.575678	1	0
ABCA10	10349	broad.mit.edu	37	17	67152030	67152030	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:67152030C>A	ENST00000269081.4	-	30	4401	c.3492G>T	c.(3490-3492)ccG>ccT	p.P1164P	ABCA10_ENST00000416101.2_3'UTR|ABCA10_ENST00000519732.1_5'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	1164					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					CGGGCTCTTCCGGATTGGGAT	0.413000													63	38					8.92729e-27	1.75195e-26	0.870114	1	0
SERPINA9	327657	broad.mit.edu	37	14	94935588	94935588	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:94935588A>G	ENST00000337425.5	-	2	718	c.644T>C	c.(643-645)cTg>cCg	p.L215P	SERPINA9_ENST00000546329.1_Missense_Mutation_p.L179P|SERPINA9_ENST00000448305.2_Missense_Mutation_p.L117P|SERPINA9_ENST00000424550.2_Missense_Mutation_p.L66P|SERPINA9_ENST00000298845.7_Missense_Mutation_p.L115P|SERPINA9_ENST00000380365.3_Missense_Mutation_p.L197P	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	197					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CATGGCCGTCAGAAGGTCAAG	0.403000													66	94					0	0	0.870114	0	0
CEP89	84902	broad.mit.edu	37	19	33450886	33450886	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:33450886G>T	ENST00000305768.4	-	3	313	c.225C>A	c.(223-225)tcC>tcA	p.S75S	CEP89_ENST00000590597.1_Silent_p.S75S	NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	75						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						TCTCAGACCGGGACCTCTGGC	0.582000													98	19					9.53958e-58	2.13478e-57	0.870114	1	0
LMO7	4008	broad.mit.edu	37	13	76430679	76430679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:76430679C>T	ENST00000357063.3	+	30	6115	c.4855C>T	c.(4855-4857)Cag>Tag	p.Q1619*	LMO7_ENST00000377534.3_Intron|LMO7_ENST00000465261.2_Nonsense_Mutation_p.Q1334*|LMO7_ENST00000526202.1_Missense_Mutation_p.S1247L|LMO7_ENST00000341547.4_Missense_Mutation_p.S1321L|LMO7_ENST00000321797.8_Missense_Mutation_p.S1370L			Q8WWI1	LMO7_HUMAN	LIM domain 7	0	LIM zinc-binding.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGCTCTTCCTCAGGAGCTGAA	0.453000													11	52					0	0	0.479597	0	0
POU2AF1	5450	broad.mit.edu	37	11	111229626	111229626	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:111229626C>A	ENST00000393067.3	-	2	548	c.34G>T	c.(34-36)Gcc>Tcc	p.A12S		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	12					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		GGGGCTGGGGCTTGCTCCGGA	0.637000			T	BCL6	NHL								20	49					7.33532e-06	8.56926e-06	0.667858	1	0
RELN	5649	broad.mit.edu	37	7	103629665	103629665	+	Nonsense_Mutation	SNP	C	C	A	rs139648092	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:103629665C>A	ENST00000428762.1	-	1	298	c.139G>T	c.(139-141)Gaa>Taa	p.E47*	RELN_ENST00000343529.5_Nonsense_Mutation_p.E47*|RELN_ENST00000424685.2_Nonsense_Mutation_p.E47*	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	47	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCATCCCCTTCCAGCTCCCCG	0.632000													26	59					1.88708e-17	3.19379e-17	0.729181	1	0
HK2	3099	broad.mit.edu	37	2	75115061	75115061	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:75115061G>T	ENST00000290573.2	+	16	2851	c.2251G>T	c.(2251-2253)Ggt>Tgt	p.G751C	HK2_ENST00000409174.1_Missense_Mutation_p.G723C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	751	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						AATGTACCTGGGTGAGATTGT	0.493000													113	97					2.23784e-72	5.07423e-72	0.870114	1	0
ING1	3621	broad.mit.edu	37	13	111371742	111371742	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:111371742C>A	ENST00000375774.3	+	2	1194	c.732C>A	c.(730-732)aaC>aaA	p.N244K	ING1_ENST00000375775.3_Missense_Mutation_p.N32K|ING1_ENST00000464141.1_3'UTR|ING1_ENST00000338450.7_Missense_Mutation_p.N57K|ING1_ENST00000333219.7_Missense_Mutation_p.N101K	NM_005537.4	NP_005528.3	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1	244					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			endometrium(4)|large_intestine(6)|lung(1)|ovary(1)	12	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TGGTGGAGAACCGCACGCGGC	0.682000													12	1013					2.27111e-07	2.82127e-07	0.411799	1	0
ITGAX	3687	broad.mit.edu	37	16	31367247	31367247	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:31367247C>A	ENST00000268296.4	+	2	192	c.71C>A	c.(70-72)aCa>aAa	p.T24K	ITGAX_ENST00000562522.1_Missense_Mutation_p.T24K|ITGAX_ENST00000562918.1_3'UTR	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	24					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AACTTGGACACAGAGGAGCTG	0.587000													67	135					1.4051e-37	2.99141e-37	0.870114	1	0
CABP1	9478	broad.mit.edu	37	12	121094023	121094023	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:121094023T>G	ENST00000453000.1	+	1	922	c.410T>G	c.(409-411)cTg>cGg	p.L137R	CABP1_ENST00000351200.2_Intron|CABP1_ENST00000316803.3_Intron|CABP1_ENST00000288616.3_Missense_Mutation_p.L58R			Q9NZU7	CABP1_HUMAN	calcium binding protein 1	0	Pro-rich.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CACAACCTGCTGGGCCCTGCC	0.647000													9	27					0	0	0.361761	0	0
PINK1	65018	broad.mit.edu	37	1	20964599	20964599	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:20964599A>C	ENST00000321556.4	+	2	746	c.652A>C	c.(652-654)Atc>Ctc	p.I218L		NM_032409.2	NP_115785.1	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1	218	Protein kinase.				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)	14		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCCCTTGGCCATCAAGATGAT	0.557000													8	25					0	0	0.335167	0	0
VRK2	7444	broad.mit.edu	37	2	58315571	58315571	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:58315571G>T	ENST00000435505.2	+	9	1185	c.440G>T	c.(439-441)gGt>gTt	p.G147V	VRK2_ENST00000417641.2_Missense_Mutation_p.G147V|VRK2_ENST00000340157.4_Missense_Mutation_p.G147V|VRK2_ENST00000440705.2_Missense_Mutation_p.G124V|VRK2_ENST00000412104.2_Missense_Mutation_p.G147V			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	147	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						CTGCAATTAGGTATCCGAATG	0.338000													46	106					1.67753e-36	3.53935e-36	0.870114	1	0
MMP15	4324	broad.mit.edu	37	16	58071439	58071439	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:58071439G>T	ENST00000219271.3	+	2	1011	c.226G>T	c.(226-228)Gcc>Tcc	p.A76S		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	76					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						CATGCGTTCCGCCCAGATCTT	0.612000													44	28					6.3091e-27	1.23943e-26	0.870114	1	0
MYO5A	4644	broad.mit.edu	37	15	52689527	52689527	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:52689527G>A	ENST00000399231.3	-	10	1433	c.1190C>T	c.(1189-1191)aCa>aTa	p.T397I	MYO5A_ENST00000356338.6_Missense_Mutation_p.T397I|MYO5A_ENST00000553916.1_Missense_Mutation_p.T397I|MYO5A_ENST00000358212.6_Missense_Mutation_p.T397I|MYO5A_ENST00000399233.2_Missense_Mutation_p.T397I	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	397	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCGGGCATTTGTGGCCTGCAG	0.502000													17	57					0	0	0.608945	0	0
TLDC2	140711	broad.mit.edu	37	20	35506305	35506305	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:35506305A>T	ENST00000217320.3	+	2	81	c.37A>T	c.(37-39)Agc>Tgc	p.S13C	TLDC2_ENST00000602922.1_Missense_Mutation_p.S13C	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		TTTGCAGCCCAGCCAGGTGGA	0.617000													22	43					0	0	0.717897	0	0
PLD3	23646	broad.mit.edu	37	19	40877731	40877731	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:40877731C>T	ENST00000409587.1	+	9	1227	c.830C>T	c.(829-831)aCa>aTa	p.T277I	PLD3_ENST00000409419.1_Missense_Mutation_p.T277I|PLD3_ENST00000409735.4_Missense_Mutation_p.T277I|PLD3_ENST00000356508.5_Missense_Mutation_p.T277I|PLD3_ENST00000409281.1_Missense_Mutation_p.T277I			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	277					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			AACCAAGAGACACCAATGGAG	0.597000													11	97					0	0	0.361761	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289911	98289911	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:98289911C>A	ENST00000322128.3	-	1	265	c.162G>T	c.(160-162)caG>caT	p.Q54H		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	54					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CCGCGCCAGCCTGCACCTGTG	0.746000													3	11					2.56e-06	3.05318e-06	0.150653	1	0
DLEC1	9940	broad.mit.edu	37	3	38080861	38080861	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:38080861C>A	ENST00000308059.6	+	1	166	c.145C>A	c.(145-147)Ctc>Atc	p.L49I	DLEC1_ENST00000452631.2_Missense_Mutation_p.L49I|DLEC1_ENST00000346219.3_Missense_Mutation_p.L49I			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	49					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTATTCCTCCCTCGCCTACTC	0.672000													13	49					1.49906e-05	1.72026e-05	0.457914	1	0
PKP1	5317	broad.mit.edu	37	1	201292277	201292277	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:201292277G>T	ENST00000263946.3	+	10	1954	c.1703G>T	c.(1702-1704)tGt>tTt	p.C568F	PKP1_ENST00000367324.3_Missense_Mutation_p.C547F|PKP1_ENST00000352845.3_Missense_Mutation_p.C568F	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	568					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CTGGAGGCCTGTGCTGGTGCC	0.602000													35	107					1.57945e-13	2.4385e-13	0.859065	1	0
LAMA2	3908	broad.mit.edu	37	6	129371169	129371169	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:129371169C>G	ENST00000421865.2	+	2	268	c.219C>G	c.(217-219)gtC>gtG	p.V73V		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	73	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TAGAACATGTCCCTGGGCAGC	0.473000													44	13					0	0	0.870114	0	0
F8	2157	broad.mit.edu	37	X	154157734	154157734	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:154157734T>C	ENST00000360256.4	-	14	4531	c.4331A>G	c.(4330-4332)gAt>gGt	p.D1444G		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1444	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GACCCCAGAATCTTTCTTTCT	0.388000													23	132					0	0	0.750413	0	0
GPR110	266977	broad.mit.edu	37	6	46977116	46977116	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:46977116C>A	ENST00000371253.2	-	11	2270	c.2055G>T	c.(2053-2055)cgG>cgT	p.R685R	GPR110_ENST00000283297.5_Silent_p.R488R|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	685					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CGAGGATGATCCGGTAAGCCA	0.483000													14	22					0.00244969	0.00261208	0.457914	1	0
AMER1	139285	broad.mit.edu	37	X	63412015	63412015	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:63412015C>A	ENST00000330258.3	-	2	1424	c.1152G>T	c.(1150-1152)gaG>gaT	p.E384D	AMER1_ENST00000374869.3_Missense_Mutation_p.E384D|AMER1_ENST00000403336.1_Missense_Mutation_p.E384D	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									cctcttcttcctcttcttcct	0.502000													12	36					0.0167234	0.0173216	0.435327	1	0
RBCK1	10616	broad.mit.edu	37	20	398183	398183	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:398183G>A	ENST00000356286.5	+	3	886	c.181G>A	c.(181-183)Gtg>Atg	p.V61M	RBCK1_ENST00000382181.2_5'UTR|RBCK1_ENST00000353660.3_Missense_Mutation_p.V19M	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	61	Interaction with IRF3.|Interaction with TAB2.|Ubiquitin-like.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GTGGGTGAGCGTGGAGGATGC	0.602000													14	94					0	0	0.608945	0	0
ASTN2	23245	broad.mit.edu	37	9	119976950	119976950	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:119976950C>T	ENST00000313400.4	-	3	802	c.702G>A	c.(700-702)caG>caA	p.Q234Q	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Silent_p.Q234Q|ASTN2_ENST00000373996.3_Silent_p.Q234Q			O75129	ASTN2_HUMAN	astrotactin 2	234						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GGCGACGCTTCTGCCAACGTC	0.627000													25	26					0	0	0.654019	0	0
CEP128	145508	broad.mit.edu	37	14	80963830	80963830	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:80963830C>A	ENST00000555265.1	-	25	3652	c.3277G>T	c.(3277-3279)Ggg>Tgg	p.G1093W	CEP128_ENST00000281129.3_Missense_Mutation_p.G1093W			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	1093						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TTTTAGCTCCCATATTCCTCT	0.348000													8	18					3.09899e-07	3.82696e-07	0.307466	1	0
LDLRAD4	753	broad.mit.edu	37	18	13645452	13645452	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:13645452A>T	ENST00000361205.4	+	7	1385	c.717A>T	c.(715-717)gcA>gcT	p.A239A	LDLRAD4_ENST00000585931.1_Silent_p.A162A|LDLRAD4_ENST00000587757.1_Silent_p.A202A|LDLRAD4_ENST00000359446.5_Silent_p.A239A|LDLRAD4_ENST00000592991.1_Silent_p.A141A|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000399848.3_Silent_p.A221A|LDLRAD4_ENST00000586765.1_Silent_p.A184A	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		GCATCAGTGCAAGCACCTGCA	0.592000													14	80					0	0	0.520397	0	0
BEST3	144453	broad.mit.edu	37	12	70049296	70049296	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:70049296C>A	ENST00000330891.5	-	10	1624	c.1398G>T	c.(1396-1398)atG>atT	p.M466I	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000488961.1_Missense_Mutation_p.M253I|BEST3_ENST00000553096.1_Missense_Mutation_p.M360I	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	466						chloride channel complex|plasma membrane	chloride channel activity	p.M466I(1)|p.M253I(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAGCTCTCCCATGCTGAAGT	0.582000													30	52					2.09667e-21	3.86098e-21	0.788014	1	0
COL5A3	50509	broad.mit.edu	37	19	10097252	10097252	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:10097252C>T	ENST00000264828.3	-	29	2306	c.2221G>A	c.(2221-2223)Gat>Aat	p.D741N		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	741	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGCCCCACATCGCCCTTGAAG	0.627000													39	105					0	0	0.870114	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904621	73904621	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:73904621C>A	ENST00000342056.2	+	15	2738	c.2340C>A	c.(2338-2340)ccC>ccA	p.P780P	KCNQ5_ENST00000355635.3_Silent_p.P762P|KCNQ5_ENST00000403813.2_Silent_p.P752P|KCNQ5_ENST00000355194.4_Silent_p.P761P|KCNQ5_ENST00000414165.2_Silent_p.P651P|KCNQ5_ENST00000402622.2_Silent_p.P771P|KCNQ5_ENST00000370398.1_Silent_p.P761P	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	761					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AGCATCTGCCCAGGCCAGAAA	0.527000													4	77					0.00909568	0.00946796	0.150653	1	0
MASP1	5648	broad.mit.edu	37	3	186943279	186943279	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:186943279C>A	ENST00000337774.5	-	13	1963	c.1574G>T	c.(1573-1575)cGg>cTg	p.R525L		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	525	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity	p.R525Q(1)		NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTCATCTGACCGGAGCCTCCA	0.557000													72	166					4.38691e-48	9.69033e-48	0.870114	1	0
ILDR2	387597	broad.mit.edu	37	1	166927016	166927016	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:166927016C>A	ENST00000271417.3	-	2	424	c.369G>T	c.(367-369)acG>acT	p.T123T	ILDR2_ENST00000469934.2_Silent_p.T123T|ILDR2_ENST00000526687.1_Silent_p.T123T|ILDR2_ENST00000529071.1_Silent_p.T123T|ILDR2_ENST00000529387.1_Silent_p.T123T|ILDR2_ENST00000525740.1_Silent_p.T123T|ILDR2_ENST00000528703.1_Silent_p.T123T	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	123	Ig-like V-type.					integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						CATGAACAATCGTGATCTCTC	0.448000													46	83					2.48909e-17	4.19755e-17	0.870114	1	0
C3P1	388503	broad.mit.edu	37	19	10157449	10157449	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:10157449G>A	ENST00000495140.1	+	0	1048																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						TGGATGACATGCCTGTGCGGA	0.517000													19	49					0	0	0.639603	0	0
TIMP4	7079	broad.mit.edu	37	3	12195177	12195177	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:12195177C>A	ENST00000287814.4	-	5	1023	c.513G>T	c.(511-513)tcG>tcT	p.S171S	SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4	171							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						CGTTAGGGGCCGAGATGGTAC	0.498000													21	67					3.5997e-14	5.64553e-14	0.624587	1	0
LPHN3	23284	broad.mit.edu	37	4	62845314	62845314	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:62845314G>C	ENST00000512091.1	+	17	3382	c.2635G>C	c.(2635-2637)Gtg>Ctg	p.V879L	LPHN3_ENST00000514996.1_Missense_Mutation_p.V879L|LPHN3_ENST00000509896.1_Missense_Mutation_p.V947L|LPHN3_ENST00000508693.1_Missense_Mutation_p.V947L|LPHN3_ENST00000506700.1_Missense_Mutation_p.V879L|LPHN3_ENST00000508946.1_Missense_Mutation_p.V879L|LPHN3_ENST00000506720.1_Missense_Mutation_p.V947L|LPHN3_ENST00000506746.1_Missense_Mutation_p.V947L|LPHN3_ENST00000511324.1_Missense_Mutation_p.V947L|LPHN3_ENST00000507625.1_Missense_Mutation_p.V947L|LPHN3_ENST00000504896.1_Missense_Mutation_p.V879L|LPHN3_ENST00000545650.1_Missense_Mutation_p.V879L|LPHN3_ENST00000514157.1_Missense_Mutation_p.V879L|LPHN3_ENST00000514591.1_Missense_Mutation_p.V879L|LPHN3_ENST00000507164.1_Missense_Mutation_p.V947L			Q9HAR2	LPHN3_HUMAN	latrophilin 3	866					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.V879L(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCTTCTGGATGTGATCACGTG	0.448000													36	96					0	0	0.847076	0	0
NOVA1	4857	broad.mit.edu	37	14	26917568	26917568	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:26917568C>G	ENST00000539517.2	-	5	1438	c.1121G>C	c.(1120-1122)aGc>aCc	p.S374T	NOVA1_ENST00000267422.7_Missense_Mutation_p.S252T|NOVA1_ENST00000465357.2_Missense_Mutation_p.S350T	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	377	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		ACCAGCTGTGCTGCCACTGGC	0.582000													4	18					0	0	0.361761	0	0
RECK	8434	broad.mit.edu	37	9	36121570	36121570	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:36121570A>G	ENST00000377966.3	+	20	3145	c.2579A>G	c.(2578-2580)cAg>cGg	p.Q860R		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	860						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GAAATACTTCAGAAAATCCGC	0.383000													24	117					0	0	0.667858	0	0
ATXN2	6311	broad.mit.edu	37	12	111923603	111923603	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:111923603G>A	ENST00000377617.3	-	17	3012	c.2851C>T	c.(2851-2853)Cat>Tat	p.H951Y	ATXN2_ENST00000542287.2_Missense_Mutation_p.H686Y|ATXN2_ENST00000535949.1_Missense_Mutation_p.H662Y|ATXN2_ENST00000389153.4_Missense_Mutation_p.H686Y|ATXN2_ENST00000550104.1_Missense_Mutation_p.H951Y	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	951	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						GGCTGTTGATGACCCACCATA	0.443000													16	68					0	0	0.557998	0	0
GPR152	390212	broad.mit.edu	37	11	67219557	67219557	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:67219557C>A	ENST00000312457.2	-	1	643	c.639G>T	c.(637-639)gtG>gtT	p.V213V		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	213						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCTGGGTGAGCACGTGGCAGA	0.662000													14	36					6.31663e-08	8.01611e-08	0.479597	1	0
NINL	22981	broad.mit.edu	37	20	25442267	25442267	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:25442267T>A	ENST00000278886.6	-	21	3660	c.3587A>T	c.(3586-3588)gAc>gTc	p.D1196V	NINL_ENST00000422516.1_Missense_Mutation_p.D847V	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1196					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TTGGATTTGGTCACTCTGTTT	0.393000													15	21					0	0	0.457914	0	0
VAT1L	57687	broad.mit.edu	37	16	77859152	77859152	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:77859152C>A	ENST00000302536.2	+	3	526	c.373C>A	c.(373-375)Cgt>Agt	p.R125S		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	125							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						GATTGGAGACCGTGTCATGGC	0.537000													22	31					1.96895e-08	2.54503e-08	0.639603	1	0
OPN1LW	5956	broad.mit.edu	37	X	153416360	153416360	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153416360C>G	ENST00000369951.4	+	2	405	c.345C>G	c.(343-345)gtC>gtG	p.V115V	OPN1LW_ENST00000463296.1_3'UTR	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	115					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGAACCAGGTCTCTGGCTACT	0.617000													22	203					0	0	0.693898	0	0
OR2T27	403239	broad.mit.edu	37	1	248814163	248814163	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:248814163A>T	ENST00000344889.3	-	1	22	c.23T>A	c.(22-24)gTg>gAg	p.V8E		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCGGCATACACGGAATAATT	0.438000													9	59					0	0	0.387290	0	0
TENM1	10178	broad.mit.edu	37	X	123785918	123785918	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123785918G>T	ENST00000422452.2	-	8	1488	c.1425C>A	c.(1423-1425)ggC>ggA	p.G475G	TENM1_ENST00000371130.3_Silent_p.G475G	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TATCATCAGAGCCCTTGGAGT	0.438000													9	23					1.76689e-08	2.28857e-08	0.335167	1	0
EGFLAM	133584	broad.mit.edu	37	5	38438429	38438429	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:38438429T>A	ENST00000322350.5	+	17	2682	c.2336T>A	c.(2335-2337)gTg>gAg	p.V779E	EGFLAM_ENST00000354891.3_Missense_Mutation_p.V779E|EGFLAM_ENST00000397202.2_Missense_Mutation_p.V145E|EGFLAM_ENST00000336740.6_Missense_Mutation_p.V545E	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	779	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					ACCTCCGGAGTGAATGTGGAG	0.517000													8	40					0	0	0.435327	0	0
TMTC4	84899	broad.mit.edu	37	13	101316590	101316590	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:101316590C>A	ENST00000342624.5	-	4	478	c.219_splice	c.e4-1	p.D74_splice	TMTC4_ENST00000328767.5_Intron|TMTC4_ENST00000376234.3_Splice_Site_p.D55_splice	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	55						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCTTGGAGGTCCTGCAGGGTC	0.597000													10	39					2.80697e-09	3.77607e-09	0.387290	1	0
C2orf78	388960	broad.mit.edu	37	2	74042687	74042687	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:74042687C>G	ENST00000409561.1	+	3	1458	c.1337C>G	c.(1336-1338)aCa>aGa	p.T446R		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	446										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						GACATCACTACATGGGTGGAG	0.448000													17	70					0	0	0.592651	0	0
DCDC1	341019	broad.mit.edu	37	11	31312344	31312344	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:31312344A>T	ENST00000597505.1	-	5	809	c.810T>A	c.(808-810)ccT>ccA	p.P270P	DCDC1_ENST00000452803.1_Silent_p.P270P			P59894	DCDC1_HUMAN	doublecortin domain containing 1	270					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGATATCAGTAGGAAGCATCA	0.343000													5	38					0	0	0.217242	0	0
CHMP4C	92421	broad.mit.edu	37	8	82670728	82670728	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:82670728G>T	ENST00000297265.4	+	5	844	c.651G>T	c.(649-651)agG>agT	p.R217S		NM_152284.3	NP_689497.1	Q96CF2	CHM4C_HUMAN	charged multivesicular body protein 4C	217	Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	10						CTTCCCAGAGGGCAGAAGAAG	0.313000													15	89					1.99824e-07	2.49217e-07	0.520397	1	0
PTN	5764	broad.mit.edu	37	7	136936025	136936025	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:136936025C>A	ENST00000348225.2	-	4	830	c.403G>T	c.(403-405)Gtc>Ttc	p.V135F	PTN_ENST00000393083.2_Missense_Mutation_p.V135F	NM_002825.5	NP_002816.1	P21246	PTN_HUMAN	pleiotrophin	135					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23						GAGATGGTGACAGTCTTCTGG	0.507000													134	188					8.72773e-71	1.9766e-70	0.870114	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100757	89100757	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:89100757G>T	ENST00000393525.3	+	0	1231																											TAAAAGGTTGGTAAATGAATT	0.333000													9	25					5.4927e-09	7.29518e-09	0.307466	1	0
ATP13A1	57130	broad.mit.edu	37	19	19766434	19766434	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:19766434C>A	ENST00000357324.6	-	10	1325	c.1299G>T	c.(1297-1299)ggG>ggT	p.G433G	ATP13A1_ENST00000291503.5_Silent_p.G315G	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	433					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CCCTCTTGACCCCGAAGAGGA	0.572000													8	22					2.74318e-10	3.8242e-10	0.335167	1	0
OR5AU1	390445	broad.mit.edu	37	14	21623659	21623659	+	Missense_Mutation	SNP	C	C	A	rs138510402	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:21623659C>A	ENST00000304418.3	-	1	563	c.526G>T	c.(526-528)Gct>Tct	p.A176S		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		TTACAAATAGCGGCATAGCGG	0.498000													8	42					2.17888e-05	2.49279e-05	0.335167	1	0
HGF	3082	broad.mit.edu	37	7	81392049	81392049	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:81392049C>A	ENST00000222390.5	-	2	454	c.228G>T	c.(226-228)agG>agT	p.R76S	HGF_ENST00000423064.2_Missense_Mutation_p.R76S|HGF_ENST00000354224.6_Missense_Mutation_p.R76S|HGF_ENST00000453411.1_Missense_Mutation_p.R76S|HGF_ENST00000457544.2_Missense_Mutation_p.R76S|HGF_ENST00000453018.1_5'UTR|HGF_ENST00000444829.2_Missense_Mutation_p.R76S	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	76	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GTCCTTTATTCCTAGTACATC	0.313000													66	63					1.0532e-45	2.31286e-45	0.870114	1	0
OR6A2	8590	broad.mit.edu	37	11	6816116	6816116	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:6816116G>C	ENST00000332601.3	-	1	1012	c.824C>G	c.(823-825)aCc>aGc	p.T275S		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAACTTGTTGGTGTCAAAAGC	0.468000													27	61					0	0	0.729181	0	0
ITGA7	3679	broad.mit.edu	37	12	56091241	56091241	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:56091241G>A	ENST00000257880.7	-	11	1850	c.1631C>T	c.(1630-1632)tCg>tTg	p.S544L	ITGA7_ENST00000553804.1_Missense_Mutation_p.S504L|ITGA7_ENST00000394229.2_Missense_Mutation_p.S500L|ITGA7_ENST00000555728.1_Missense_Mutation_p.S544L|ITGA7_ENST00000394230.2_Missense_Mutation_p.S504L|ITGA7_ENST00000257879.6_Missense_Mutation_p.S500L|ITGA7_ENST00000347027.6_Missense_Mutation_p.S500L|ITGA7_ENST00000452168.2_Missense_Mutation_p.S407L			Q13683	ITA7_HUMAN	integrin, alpha 7	544					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TCACCAGACCGAGTGGCCGCC	0.622000													8	53					0	0	0.335167	0	0
MRPS28	28957	broad.mit.edu	37	8	80942275	80942275	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:80942275T>C	ENST00000276585.4	-	1	231	c.209A>G	c.(208-210)cAg>cGg	p.Q70R	TPD52_ENST00000537855.1_Intron|MRPS28_ENST00000522987.1_Intron|MRPS28_ENST00000521605.1_Missense_Mutation_p.Q70R	NM_014018.2	NP_054737.1	Q9Y2Q9	RT28_HUMAN	mitochondrial ribosomal protein S28	70						mitochondrial small ribosomal subunit				endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5	Lung NSC(7;1.86e-06)|all_lung(9;6.91e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00769)|Epithelial(68;0.0208)|all cancers(69;0.0805)			CTCCACCTTCTGTAGGGGCTC	0.657000													7	22					0	0	0.335167	0	0
ZMYM4	9202	broad.mit.edu	37	1	35881141	35881141	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:35881141C>A	ENST00000314607.6	+	28	4215	c.4135C>A	c.(4135-4137)Ctt>Att	p.L1379I	ZMYM4_ENST00000373297.2_Missense_Mutation_p.L1290I	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	1379					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACCAATCGTCCTTTTAAACAC	0.443000													7	84					0.0293803	0.0301822	0.248553	1	0
AKR7L	246181	broad.mit.edu	37	1	19596151	19596151	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:19596151C>T	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						TTCCACCTGCCGGGTGGTGGC	0.567000													12	40					0	0	0.435327	0	0
SLC26A3	1811	broad.mit.edu	37	7	107434951	107434951	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:107434951T>A	ENST00000340010.5	-	2	188	c.4A>T	c.(4-6)Att>Ttt	p.I2F	SLC26A3_ENST00000422236.2_5'UTR	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	2					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						AAGGGTTCAATCATTTTGATT	0.383000													43	44					0	0	0.870114	0	0
PLCB4	5332	broad.mit.edu	37	20	9417735	9417735	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:9417735G>C	ENST00000378501.2	+	26	2679	c.2664G>C	c.(2662-2664)caG>caC	p.Q888H	PLCB4_ENST00000414679.2_Missense_Mutation_p.Q900H|PLCB4_ENST00000278655.4_Missense_Mutation_p.Q888H|PLCB4_ENST00000378493.1_Missense_Mutation_p.Q888H|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.Q900H|PLCB4_ENST00000334005.3_Missense_Mutation_p.Q888H	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	888					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TGACCCCTCAGAGTAGCTCTG	0.532000													8	20					0	0	0.307466	0	0
FLNA	2316	broad.mit.edu	37	X	153578209	153578209	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153578209T>A	ENST00000422373.1	-	45	7584	c.7336A>T	c.(7336-7338)Acg>Tcg	p.T2446S	FLNA_ENST00000369856.3_Missense_Mutation_p.T587S|FLNA_ENST00000498491.1_5'UTR|FLNA_ENST00000360319.4_Missense_Mutation_p.T2446S|FLNA_ENST00000369850.3_Missense_Mutation_p.T2454S|FLNA_ENST00000344736.4_Missense_Mutation_p.T2414S	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2454					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCATTGCTCGTGTTCACGACG	0.637000											OREG0003592	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	55					0	0	0.278610	0	0
USP9X	8239	broad.mit.edu	37	X	40994008	40994008	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:40994008G>A	ENST00000324545.7	+	5	986	c.353G>A	c.(352-354)cGa>cAa	p.R118Q	USP9X_ENST00000378308.2_Missense_Mutation_p.R118Q	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	118					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						GCATGTCAGCGATTTTTCCGT	0.353000													42	67					0	0	0.870114	0	0
BAGE2	85319	broad.mit.edu	37	21	11098773	11098773	+	RNA	SNP	G	G	A	rs77771067		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:11098773G>A	ENST00000470054.1	-	0	152									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		cgctcaggccgccctcctaac	0.627000													13	192					0	0	0.520397	0	0
ANKRD45	339416	broad.mit.edu	37	1	173616095	173616095	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:173616095A>T	ENST00000333279.2	-	3	446	c.386T>A	c.(385-387)cTg>cAg	p.L129Q		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	145										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						CAGTTCTACCAGTGCTTTCAA	0.433000													8	66					0	0	0.307466	0	0
COPA	1314	broad.mit.edu	37	1	160293314	160293314	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:160293314C>A	ENST00000241704.7	-	8	842	c.613G>T	c.(613-615)Gat>Tat	p.D205Y	COPA_ENST00000368069.3_Missense_Mutation_p.D205Y	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	205					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTCCACGATCGTGACCCTGT	0.438000													24	24					2.48779e-11	3.60156e-11	0.693898	1	0
CLRN3	119467	broad.mit.edu	37	10	129690842	129690842	+	Silent	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:129690842T>G	ENST00000368671.3	-	1	369	c.207A>C	c.(205-207)gcA>gcC	p.A69A		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	69						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				TCTTTGGTTCTGCAAGTCCGT	0.358000													13	55					0	0	0.435327	0	0
NTM	50863	broad.mit.edu	37	11	132016188	132016188	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:132016188C>T	ENST00000374786.1	+	2	659	c.180C>T	c.(178-180)gaC>gaT	p.D60D	NTM_ENST00000374791.3_Silent_p.D60D|NTM_ENST00000427481.2_Silent_p.D51D|NTM_ENST00000425719.2_Silent_p.D60D|NTM_ENST00000539799.1_Silent_p.D60D|NTM_ENST00000374784.1_Silent_p.D60D	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	60	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GCACTATTGACAACCGGGTCA	0.567000													10	55					0	0	0.411799	0	0
FLNA	2316	broad.mit.edu	37	X	153593596	153593596	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153593596C>A	ENST00000422373.1	-	11	1847	c.1599G>T	c.(1597-1599)ctG>ctT	p.L533L	FLNA_ENST00000360319.4_Silent_p.L533L|FLNA_ENST00000369850.3_Silent_p.L533L|FLNA_ENST00000344736.4_Silent_p.L533L	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	533					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGCCATCCCCCAGGTCCTTCT	0.637000													27	167					8.16721e-17	1.36024e-16	0.750413	1	0
BNC2	54796	broad.mit.edu	37	9	16435886	16435886	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:16435886T>A	ENST00000380672.4	-	6	2363	c.2306A>T	c.(2305-2307)cAg>cTg	p.Q769L	BNC2_ENST00000380667.2_Missense_Mutation_p.Q702L|BNC2_ENST00000545497.1_Missense_Mutation_p.Q674L|BNC2_ENST00000380666.2_Missense_Mutation_p.Q769L	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	769					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GATGACGTCCTGGTGAGAGGG	0.498000													12	60					0	0	0.435327	0	0
MSRB2	22921	broad.mit.edu	37	10	23393072	23393072	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:23393072G>T	ENST00000376510.3	+	2	221		c.e2-1			NM_012228.3	NP_036360.3	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2						protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	9					L-Methionine(DB00134)	TAACAATACAGGGTCTCTTGC	0.428000													32	31					2.26627e-22	4.23548e-22	0.834066	1	0
SH3TC2	79628	broad.mit.edu	37	5	148407657	148407657	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:148407657C>A	ENST00000538184.1	-	7	1167	c.279G>T	c.(277-279)caG>caT	p.Q93H	SH3TC2_ENST00000394358.2_Missense_Mutation_p.Q431H|SH3TC2_ENST00000515425.1_Missense_Mutation_p.Q546H|SH3TC2_ENST00000512049.1_Missense_Mutation_p.Q539H			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	546							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACCCTGGCCTGAGAGAGTT	0.552000													271	53					1.41736e-133	3.25302e-133	0.870114	1	0
DLL3	10683	broad.mit.edu	37	19	39998106	39998106	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:39998106C>A	ENST00000205143.4	+	7	1528	c.1521C>A	c.(1519-1521)ggC>ggA	p.G507G	DLL3_ENST00000356433.5_Silent_p.G507G	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	507					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCGTGGCCGGCGCTGCGCTCT	0.751000													3	6					0.00909568	0.00946796	0.150653	1	0
ADCY8	114	broad.mit.edu	37	8	131796023	131796023	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:131796023C>A	ENST00000286355.5	-	17	5274	c.3182G>T	c.(3181-3183)tGt>tTt	p.C1061F	ADCY8_ENST00000377928.3_Missense_Mutation_p.C930F	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1061					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGCCAGAGCACACAAATGTCC	0.453000										HNSCC(32;0.087)			51	38					1.84395e-34	3.82193e-34	0.870114	1	0
SEPT9	10801	broad.mit.edu	37	17	75484933	75484933	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:75484933G>T	ENST00000329047.8	+	6	2007	c.1195G>T	c.(1195-1197)Gcc>Tcc	p.A399S	SEPT9_ENST00000588690.1_Missense_Mutation_p.A253S|SEPT9_ENST00000449803.2_Missense_Mutation_p.A253S|SEPT9_ENST00000592481.1_3'UTR|SEPT9_ENST00000585930.1_Missense_Mutation_p.A193S|SEPT9_ENST00000427177.1_Missense_Mutation_p.A417S|SEPT9_ENST00000590294.1_Missense_Mutation_p.A399S|SEPT9_ENST00000427674.2_Missense_Mutation_p.A253S|SEPT9_ENST00000427180.1_Missense_Mutation_p.A305S|SEPT9_ENST00000431235.2_Missense_Mutation_p.A253S|SEPT9_ENST00000541152.2_Missense_Mutation_p.A166S|SEPT9_ENST00000591088.1_Missense_Mutation_p.A166S|SEPT9_ENST00000423034.2_Missense_Mutation_p.A410S|SEPT9_ENST00000591198.1_Missense_Mutation_p.A398S|SEPT9_ENST00000592951.1_Missense_Mutation_p.A166S	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	417					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CTTCATCCCCGCCACCGGCCA	0.627000													23	36					6.32553e-13	9.56965e-13	0.681144	1	0
KCNK9	51305	broad.mit.edu	37	8	140631105	140631105	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:140631105C>A	ENST00000520439.1	-	2	584	c.521G>T	c.(520-522)gGg>gTg	p.G174V	KCNK9_ENST00000303015.1_Missense_Mutation_p.G174V			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	174						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GGCGGCCGCCCCGATGCACAG	0.567000													30	21					0.001512	0.00162326	0.729181	1	0
NR1H4	9971	broad.mit.edu	37	12	100904667	100904667	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:100904667C>T	ENST00000548884.1	+	4	732	c.191C>T	c.(190-192)tCa>tTa	p.S64L	NR1H4_ENST00000551379.1_Missense_Mutation_p.S74L|NR1H4_ENST00000188403.7_Missense_Mutation_p.S74L|NR1H4_ENST00000549996.1_Missense_Mutation_p.S64L|NR1H4_ENST00000392986.3_Missense_Mutation_p.S64L	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	74					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						ATTTCCTCGTCATCCTATTAT	0.493000													19	82					0	0	0.654019	0	0
FKBP9	11328	broad.mit.edu	37	7	32997399	32997399	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:32997399G>A	ENST00000242209.4	+	1	383	c.214G>A	c.(214-216)Gac>Aac	p.D72N	FKBP9_ENST00000538443.1_5'UTR|FKBP9_ENST00000538336.1_Missense_Mutation_p.D72N|AVL9_ENST00000404479.1_Intron	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	72	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			CCAGAAGTTCGACTCCAGGTA	0.721000													4	17					0	0	0.217242	0	0
FLNC	2318	broad.mit.edu	37	7	128485009	128485009	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:128485009G>T	ENST00000325888.8	+	21	3751	c.3490G>T	c.(3490-3492)Ggc>Tgc	p.G1164C	FLNC_ENST00000346177.6_Missense_Mutation_p.G1164C	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1164					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAGTGGACCGGGCCTGGAGCG	0.637000													28	71					3.73148e-12	5.55589e-12	0.717897	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690499	77690499	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:77690499C>T	ENST00000521891.2	+	4	3597	c.3149C>T	c.(3148-3150)gCc>gTc	p.A1050V	ZFHX4_ENST00000455469.2_Missense_Mutation_p.A1024V|ZFHX4_ENST00000517683.1_3'UTR|ZFHX4_ENST00000050961.6_Missense_Mutation_p.A1024V|ZFHX4_ENST00000518282.1_Missense_Mutation_p.A1024V	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1024						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACTACTGTGCCGTGTGTGAT	0.507000										HNSCC(33;0.089)			7	131					0	0	0.361761	0	0
OR4M1	441670	broad.mit.edu	37	14	20248975	20248975	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:20248975G>T	ENST00000315957.4	+	1	575	c.494G>T	c.(493-495)cGa>cTa	p.R165L		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTCATTGTTCGACTTCCTTTC	0.493000													53	260					1.07363e-35	2.2551e-35	0.870114	1	0
USH2A	7399	broad.mit.edu	37	1	216538408	216538408	+	Missense_Mutation	SNP	C	C	A	rs142234324		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:216538408C>A	ENST00000366943.2	-	4	1057	c.671G>T	c.(670-672)aGc>aTc	p.S224I	USH2A_ENST00000366942.3_Missense_Mutation_p.S224I|USH2A_ENST00000307340.3_Missense_Mutation_p.S224I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	224					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GATAAAGAAGCTGATTTTTGT	0.323000										HNSCC(13;0.011)			19	87					1.17739e-12	1.76985e-12	0.693898	1	0
POM121L12	285877	broad.mit.edu	37	7	53104032	53104032	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:53104032A>G	ENST00000408890.4	+	1	684	c.668A>G	c.(667-669)aAt>aGt	p.N223S		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	223										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CTGAGCAAAAATGGAGCGGTT	0.632000													14	70					0	0	0.479597	0	0
C12orf49	79794	broad.mit.edu	37	12	117175637	117175637	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:117175637G>A	ENST00000536380.1	-	1	237	c.136C>T	c.(136-138)Cgg>Tgg	p.R46W	C12orf49_ENST00000261318.3_Silent_p.F23F			Q9H741	CL049_HUMAN	chromosome 12 open reading frame 49	0						extracellular region				endometrium(1)|lung(1)|ovary(1)|skin(1)	4	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		GCGACAGCCCGAAGACCAGGG	0.687000													7	40					0	0	0.335167	0	0
FDX1L	112812	broad.mit.edu	37	19	10426617	10426617	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:10426617G>A	ENST00000541276.1	-	1	68	c.65C>T	c.(64-66)gCc>gTc	p.A22V	FDX1L_ENST00000494368.1_Intron|CTD-2369P2.10_ENST00000452032.2_Missense_Mutation_p.A19V|CTD-2369P2.12_ENST00000586529.1_Intron|FDX1L_ENST00000393708.3_Missense_Mutation_p.A19V			Q6P4F2	ADXL_HUMAN	ferredoxin 1-like	19					electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(20;9.5e-10)|Epithelial(33;2.11e-06)|all cancers(31;5.06e-06)			GGTGCCCCTGGCAGCCTGCAG	0.672000													35	14					0	0	0.788014	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604692	140604692	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140604692C>A	ENST00000239449.4	+	1	1615	c.1615C>A	c.(1615-1617)Ccg>Acg	p.P539T	PCDHB14_ENST00000515856.2_Missense_Mutation_p.P386T	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		539	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGCGGGTCCCCGGCGTTGAG	0.672000													22	24					1.33986e-20	2.43635e-20	0.681144	1	0
UMOD	7369	broad.mit.edu	37	16	20352475	20352475	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:20352475G>A	ENST00000396134.2	-	8	1737	c.1614C>T	c.(1612-1614)aaC>aaT	p.N538N	UMOD_ENST00000302509.4_Silent_p.N505N|UMOD_ENST00000424589.1_Silent_p.N538N|UMOD_ENST00000396138.4_Silent_p.N554N|UMOD_ENST00000396142.2_Silent_p.N505N|UMOD_ENST00000570689.1_Silent_p.N505N|UMOD_ENST00000570331.1_5'UTR	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	505	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TGGCATAGCAGTTGGTCATGA	0.547000													17	61					0	0	0.608945	0	0
OR6N2	81442	broad.mit.edu	37	1	158747406	158747406	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158747406G>T	ENST00000339258.1	-	1	19	c.20C>A	c.(19-21)tCa>tAa	p.S7*		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					AGCCAGGCTTGAATGGTTGTA	0.458000													10	60					6.40141e-05	7.20973e-05	0.387290	1	0
RORB	6096	broad.mit.edu	37	9	77300496	77300496	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:77300496G>T	ENST00000376896.2	+	10	1954	c.1342G>T	c.(1342-1344)Gag>Tag	p.E448*	RORB_ENST00000396204.2_Nonsense_Mutation_p.E459*	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	459	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						GTTATACAAGGAGCTCTTTAA	0.453000													26	93					1.30988e-24	2.5155e-24	0.750413	1	0
SLC30A8	169026	broad.mit.edu	37	8	118165223	118165223	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:118165223T>A	ENST00000427715.2	+	6	599	c.165T>A	c.(163-165)gcT>gcA	p.A55A	SLC30A8_ENST00000519688.1_Silent_p.A55A|SLC30A8_ENST00000521243.1_Silent_p.A55A|SLC30A8_ENST00000456015.2_Silent_p.A104A	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	104					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TCACAGATGCTGCCCACCTCT	0.502000													17	83					0	0	0.539581	0	0
CARKD	55739	broad.mit.edu	37	13	111277566	111277566	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:111277566C>T	ENST00000309957.2	+	4	341	c.327C>T	c.(325-327)gcC>gcT	p.A109A	CARKD_ENST00000424185.2_Intron|CARKD_ENST00000397191.4_Intron|CARKD_ENST00000470164.2_Intron|CARKD_ENST00000458711.2_Intron	NM_001242881.1|NM_018210.3	NP_001229810.1|NP_060680.2	Q8IW45	CARKD_HUMAN	carbohydrate kinase domain containing	109	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						TGTTCTGTGCCAGTGCGGCCG	0.632000													19	950					0	0	0.457914	0	0
CLEC16A	23274	broad.mit.edu	37	16	11038617	11038617	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:11038617A>T	ENST00000409790.1	+	1	273	c.43A>T	c.(43-45)Aag>Tag	p.K15*	CLEC16A_ENST00000409552.3_Nonsense_Mutation_p.K15*	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	15										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GGGCCATGGCAAGACTTCCCG	0.706000													4	20					0	0	0.184627	0	0
VPS13A	23230	broad.mit.edu	37	9	79966231	79966231	+	Splice_Site	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:79966231A>T	ENST00000360280.3	+	53	7549		c.e53-1		VPS13A_ENST00000376636.3_Splice_Site|VPS13A_ENST00000376634.4_Splice_Site|VPS13A_ENST00000357409.5_Splice_Site	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)						Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTACTGTGTCAGTTCTCTCAG	0.383000													32	90					0	0	0.804634	0	0
SLC45A1	50651	broad.mit.edu	37	1	8384596	8384596	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:8384596G>T	ENST00000471889.1	+	2	592	c.207G>T	c.(205-207)ccG>ccT	p.P69P	SLC45A1_ENST00000377479.2_Silent_p.P103P|SLC45A1_ENST00000289877.8_Silent_p.P69P			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	69					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCGTGCCCGCTTGAGCTGG	0.622000													9	79					1.58986e-06	1.90703e-06	0.361761	1	0
LDLRAD3	143458	broad.mit.edu	37	11	36103304	36103304	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:36103304G>T	ENST00000315571.5	+	3	316	c.295G>T	c.(295-297)Gat>Tat	p.D99Y	LDLRAD3_ENST00000528989.1_Missense_Mutation_p.D50Y|LDLRAD3_ENST00000524419.1_Missense_Mutation_p.D50Y	NM_174902.2	NP_777562.1	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain containing 3	99	LDL-receptor class A 2.					integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(7)|skin(1)	28	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				GGACTGTCCCGATGGCAGCGA	0.542000													38	47					1.32136e-16	2.19294e-16	0.840704	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37430799	37430799	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:37430799C>A	ENST00000374660.1	+	7	905	c.806C>A	c.(805-807)cCt>cAt	p.P269H	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.P269H|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.P269H			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	325						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GAAAAAACACCTGATGAGGCT	0.478000													14	45					1.05317e-09	1.43006e-09	0.457914	1	0
KCNA2	3737	broad.mit.edu	37	1	111146634	111146634	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:111146634G>T	ENST00000485317.1	-	3	1444	c.771C>A	c.(769-771)atC>atA	p.I257I	KCNA2_ENST00000525120.1_5'UTR|KCNA2_ENST00000316361.4_Silent_p.I257I|KCNA2_ENST00000440270.1_Silent_p.I257I|KCNA2_ENST00000369770.3_Silent_p.I257I			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	257						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CAATGTCAATGATGTTCATGA	0.517000													31	56					1.08052e-11	1.58006e-11	0.796494	1	0
OTC	5009	broad.mit.edu	37	X	38271134	38271134	+	Missense_Mutation	SNP	C	C	A	rs72558459		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:38271134C>A	ENST00000039007.4	+	9	1039	c.887C>A	c.(886-888)tCt>tAt	p.S296Y	TM4SF2_ENST00000465127.1_Intron	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	296					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	GTTGCTGCCTCTGACTGGACA	0.403000													54	135					6.72169e-28	1.33301e-27	0.870114	1	0
FAM135B	51059	broad.mit.edu	37	8	139278016	139278016	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:139278016T>A	ENST00000395297.1	-	4	397	c.227A>T	c.(226-228)tAc>tTc	p.Y76F		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	76										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCATTCCGGTATAAGATCTG	0.488000										HNSCC(54;0.14)			28	63					0	0	0.740014	0	0
BAGE2	85319	broad.mit.edu	37	21	11038772	11038772	+	RNA	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:11038772T>A	ENST00000470054.1	-	0	1431									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTCTTAGTAATAGCTGGTTTA	0.388000													7	231					0	0	0.278610	0	0
OCA2	4948	broad.mit.edu	37	15	28096594	28096594	+	Missense_Mutation	SNP	C	C	A	rs145635978		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:28096594C>A	ENST00000354638.3	-	22	2427	c.2272G>T	c.(2272-2274)Gac>Tac	p.D758Y	OCA2_ENST00000353809.5_Missense_Mutation_p.D734Y	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	758					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ACCTCAGGGTCGTGGCTCAGG	0.612000									Oculocutaneous Albinism				7	20					1.33987e-11	1.95476e-11	0.361761	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136788	40136788	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:40136788T>G	ENST00000278198.2	-	2	3018	c.1055A>C	c.(1054-1056)tAt>tCt	p.Y352S	LRRC4C_ENST00000528697.1_Missense_Mutation_p.Y352S|LRRC4C_ENST00000530763.1_Missense_Mutation_p.Y352S|LRRC4C_ENST00000527150.1_Missense_Mutation_p.Y352S			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	352	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CACCGGAGCATAGCATGTGAA	0.537000													7	65					0	0	0.278610	0	0
CPSF2	53981	broad.mit.edu	37	14	92621558	92621558	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:92621558G>A	ENST00000298875.4	+	11	1618	c.1333G>A	c.(1333-1335)Ggt>Agt	p.G445S		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	445					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		GATGATGAAAGGTGAAGGCAG	0.408000													50	75					0	0	0.870114	0	0
OR52E2	119678	broad.mit.edu	37	11	5080352	5080352	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:5080352G>T	ENST00000321522.2	-	1	505	c.506C>A	c.(505-507)cCc>cAc	p.P169H		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCACAGAAGGGCAACCGCAA	0.418000													4	20					0.00909568	0.00946796	0.150653	1	0
PLCL2	23228	broad.mit.edu	37	3	17131317	17131317	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:17131317A>T	ENST00000418129.2	+	6	3384	c.2919A>T	c.(2917-2919)aaA>aaT	p.K973N	PLCL2_ENST00000432376.1_Missense_Mutation_p.K973N	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1099					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GACTGAATAAACCAGGCACCG	0.418000													11	32					0	0	0.435327	0	0
FCHSD1	89848	broad.mit.edu	37	5	141028864	141028864	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:141028864G>T	ENST00000435817.2	-	6	437	c.387C>A	c.(385-387)aaC>aaA	p.N129K	FCHSD1_ENST00000519800.1_Missense_Mutation_p.N127K|FCHSD1_ENST00000522126.1_Missense_Mutation_p.N53K|FCHSD1_ENST00000522783.1_Missense_Mutation_p.N127K	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	129									FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCTGGAGGTTCTCTGTTC	0.582000													65	59					5.85233e-21	1.07245e-20	0.870114	1	0
CROCC	9696	broad.mit.edu	37	1	17296392	17296392	+	Missense_Mutation	SNP	G	G	T	rs146777794	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:17296392G>T	ENST00000375541.5	+	33	5483	c.5414G>T	c.(5413-5415)cGg>cTg	p.R1805L		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1805					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GAACTGCAGCGGGTGGAGGCC	0.672000													22	42					1.77063e-15	2.85792e-15	0.693898	1	0
TTLL8	164714	broad.mit.edu	37	22	50470162	50470162	+	Missense_Mutation	SNP	C	C	T	rs145946479	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:50470162C>T	ENST00000266182.6	-	11	1659	c.1660G>A	c.(1660-1662)Gtg>Atg	p.V554M	TTLL8_ENST00000440475.1_Missense_Mutation_p.V534M					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CTGCGGTCCACGGCCACCTTG	0.657000													8	10					0	0	0.307466	0	0
INSIG2	51141	broad.mit.edu	37	2	118854143	118854143	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:118854143G>T	ENST00000245787.4	+	2	217	c.11G>T	c.(10-12)gGa>gTa	p.G4V	INSIG2_ENST00000485520.1_Intron	NM_016133.2	NP_057217.2	Q9Y5U4	INSI2_HUMAN	insulin induced gene 2	4					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						ATGGCAGAAGGAGAGACAGAG	0.423000													4	32					0.00909568	0.00946796	0.150653	1	0
OR11H4	390442	broad.mit.edu	37	14	20711476	20711476	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:20711476C>A	ENST00000315409.2	+	1	579	c.526C>A	c.(526-528)Ctc>Atc	p.L176I		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CATCTCCCAACTCCCCTTCTG	0.458000													59	83					2.73361e-28	5.45563e-28	0.870114	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433149	73433149	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:73433149G>T	ENST00000263666.4	-	10	2682	c.2568C>A	c.(2566-2568)ggC>ggA	p.G856G	PDZRN3_ENST00000462146.2_Silent_p.G513G|PDZRN3_ENST00000535920.1_Silent_p.G578G|PDZRN3_ENST00000479530.1_Silent_p.G573G|PDZRN3_ENST00000466780.1_Silent_p.G513G	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	856							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGTAGGCGCTGCCCAGCTTCT	0.662000													16	35					2.35188e-11	3.41005e-11	0.539581	1	0
TPH2	121278	broad.mit.edu	37	12	72425348	72425348	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:72425348C>T	ENST00000333850.3	+	11	1487	c.1346C>T	c.(1345-1347)cCc>cTc	p.P449L		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	449					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TACTTCAATCCCTACACACAG	0.418000													15	43					0	0	0.479597	0	0
DUSP27	92235	broad.mit.edu	37	1	167095846	167095846	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:167095846G>T	ENST00000361200.2	+	6	1644	c.1478G>T	c.(1477-1479)cGg>cTg	p.R493L	DUSP27_ENST00000443333.1_Missense_Mutation_p.R493L|DUSP27_ENST00000271385.5_Missense_Mutation_p.R493L|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	493					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GAGGCTTCCCGGAGGTACCAC	0.647000													19	33					4.54149e-19	7.96559e-19	0.624587	1	0
TTYH1	57348	broad.mit.edu	37	19	54932498	54932498	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:54932498G>T	ENST00000301194.4	+	3	475	c.353G>T	c.(352-354)gGg>gTg	p.G118V	TTYH1_ENST00000376530.3_Missense_Mutation_p.G118V|TTYH1_ENST00000376531.3_Missense_Mutation_p.G118V|TTYH1_ENST00000391739.3_Missense_Mutation_p.G167V			Q9H313	TTYH1_HUMAN	tweety family member 1	118					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		ACCAGTGATGGGGTGTCCCAG	0.637000													100	94					1.64808e-60	3.69689e-60	0.870114	1	0
GNRH2	2797	broad.mit.edu	37	20	3025467	3025467	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:3025467G>T	ENST00000380347.2	+	2	681	c.276G>T	c.(274-276)ctG>ctT	p.L92L	GNRH2_ENST00000245983.2_Silent_p.L99L|GNRH2_ENST00000359100.2_Silent_p.L92L|GNRH2_ENST00000380346.2_Silent_p.L91L|GNRH2_ENST00000359987.1_Silent_p.L91L			O43555	GON2_HUMAN	gonadotropin-releasing hormone 2	99					multicellular organismal development|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)|upper_aerodigestive_tract(1)	2						AGCGACACCTGGCACGGACAC	0.642000													6	30					1.26484e-09	1.71501e-09	0.278610	1	0
MAGEB3	4114	broad.mit.edu	37	X	30254136	30254136	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:30254136C>A	ENST00000361644.2	+	5	832	c.95C>A	c.(94-96)gCa>gAa	p.A32E	MAGEB3_ENST00000378986.1_Missense_Mutation_p.A32E	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	32										NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CAGATCACTGCAACTAACAAG	0.517000													8	15					0.00448238	0.0047419	0.307466	1	0
PRDM9	56979	broad.mit.edu	37	5	23521208	23521208	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:23521208G>T	ENST00000296682.3	+	6	610	c.428G>T	c.(427-429)aGt>aTt	p.S143I		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	143					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CTGAATGCAAGTGGCTCAGAG	0.418000										HNSCC(3;0.000094)			8	53					2.74318e-10	3.8242e-10	0.335167	1	0
RASGRP2	10235	broad.mit.edu	37	11	64508532	64508532	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:64508532G>T	ENST00000377494.1	-	4	1181	c.259C>A	c.(259-261)Cca>Aca	p.P87T	RASGRP2_ENST00000377486.3_Missense_Mutation_p.P87T|RASGRP2_ENST00000394432.3_Missense_Mutation_p.P87T|RASGRP2_ENST00000394428.1_Missense_Mutation_p.P60H|RASGRP2_ENST00000394430.1_Missense_Mutation_p.P87T|RASGRP2_ENST00000377497.3_Missense_Mutation_p.P87T|RASGRP2_ENST00000377489.1_Missense_Mutation_p.P87T|RASGRP2_ENST00000394429.1_Missense_Mutation_p.P63H|RASGRP2_ENST00000354024.3_Missense_Mutation_p.P87T|RASGRP2_ENST00000377487.1_Missense_Mutation_p.P87T			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	87	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AACTCCGCTGGGAAGGCGGAG	0.567000											OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	24					0.000308642	0.000339092	0.479597	1	0
BCKDHB	594	broad.mit.edu	37	6	80837296	80837296	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:80837296G>T	ENST00000545529.1	+	2	257	c.229G>T	c.(229-231)Gta>Tta	p.V77L	BCKDHB_ENST00000486968.1_3'UTR|BCKDHB_ENST00000320393.6_Missense_Mutation_p.V77L|BCKDHB_ENST00000356489.5_Missense_Mutation_p.V77L|BCKDHB_ENST00000369760.4_Missense_Mutation_p.V77L			P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	77					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TTTCCAGTCTGTAACAAGTGC	0.358000													40	242					2.77807e-22	5.17656e-22	0.864702	1	0
CAPN12	147968	broad.mit.edu	37	19	39228214	39228214	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:39228214C>T	ENST00000328867.4	-	9	1338	c.1030G>A	c.(1030-1032)Gtg>Atg	p.V344M	CAPN12_ENST00000601953.1_Missense_Mutation_p.V195M	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	344	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GGGCCCAGCACCTCCGGGCTC	0.697000													4	29					0	0	0.184627	0	0
MCM9	254394	broad.mit.edu	37	6	119234474	119234474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:119234474C>A	ENST00000316316.6	-	6	1302	c.1016G>T	c.(1015-1017)gGa>gTa	p.G339V	MCM9_ENST00000316068.3_Missense_Mutation_p.G339V	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	339	MCM.				DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		GACCCGTGTTCCTGTAGCATC	0.418000													9	69					1.08611e-07	1.36452e-07	0.387290	1	0
NBAS	51594	broad.mit.edu	37	2	15358896	15358896	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:15358896C>A	ENST00000281513.5	-	48	6458		c.e48+1		NBAS_ENST00000441750.1_Splice_Site	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence											NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CACTCCCTTACCTGTCTCTGG	0.498000													19	56					5.35356e-11	7.65026e-11	0.639603	1	0
PACRG	135138	broad.mit.edu	37	6	163735984	163735984	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:163735984G>T	ENST00000337019.3	+	7	1080	c.856G>T	c.(856-858)Gtg>Ttg	p.V286L	PACRG_ENST00000366889.2_Missense_Mutation_p.V247L|PACRG_ENST00000366888.2_Missense_Mutation_p.V247L	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	286										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		CATTAAGTACGTGGTCCCAAC	0.507000													19	44					8.10497e-08	1.02579e-07	0.592651	1	0
BRSK1	84446	broad.mit.edu	37	19	55816285	55816285	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55816285C>T	ENST00000309383.1	+	14	1991	c.1714C>T	c.(1714-1716)Cag>Tag	p.Q572*	BRSK1_ENST00000326848.7_Nonsense_Mutation_p.Q267*|BRSK1_ENST00000590333.1_Nonsense_Mutation_p.Q588*|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	572					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCGCAAGATGCAGGGTATGGG	0.627000													50	22					0	0	0.870114	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629391	1629391	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:1629391C>G	ENST00000399685.1	-	1	302	c.225G>C	c.(223-225)ggG>ggC	p.G75G		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	75	11 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGCCACAGCCCCCCTTGCAGC	0.677000													120	74					0	0	0.870114	0	0
FBXO39	162517	broad.mit.edu	37	17	6683346	6683346	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:6683346T>A	ENST00000321535.4	+	2	289	c.159T>A	c.(157-159)gcT>gcA	p.A53A		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	53	F-box.									NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						TGTATTCTGCTGAGCTCTGGC	0.512000													31	22					0	0	0.717897	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410338	105410338	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:105410338G>C	ENST00000333244.5	-	7	11569	c.11450C>G	c.(11449-11451)gCc>gGc	p.A3817G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3817						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTTGCCTGGGGCAGACACCCC	0.587000													74	453					0	0	0.870114	0	0
SSX5	6758	broad.mit.edu	37	X	48054770	48054770	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:48054770G>T	ENST00000311798.1	-	2	77	c.25C>A	c.(25-27)Cgg>Agg	p.R9R	SSX5_ENST00000347757.1_Silent_p.R9R|SSX5_ENST00000376923.1_Silent_p.R9R	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						CTAGGTCTCCGTACAAAGGCA	0.547000													68	62					5.82419e-33	1.20056e-32	0.870114	1	0
ABCA9	10350	broad.mit.edu	37	17	66985243	66985243	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:66985243C>A	ENST00000340001.4	-	31	4183	c.3972G>T	c.(3970-3972)ctG>ctT	p.L1324L	ABCA9_ENST00000482072.1_5'UTR|ABCA9_ENST00000370732.2_Silent_p.L1324L|ABCA9_ENST00000453985.2_Silent_p.L1286L	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1324	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TGTGTCCTAACAGTCCTATAA	0.373000													14	75					1.15088e-07	1.44013e-07	0.500413	1	0
EPHB6	2051	broad.mit.edu	37	7	142562423	142562423	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142562423G>A	ENST00000392957.2	+	7	1652	c.865G>A	c.(865-867)Gag>Aag	p.E289K	EPHB6_ENST00000442129.1_Missense_Mutation_p.E289K|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	289	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CTGCAACGGGGAGGGCAAGTG	0.662000													41	98					0	0	0.870114	0	0
DCAF13	25879	broad.mit.edu	37	8	104438329	104438329	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:104438329G>T	ENST00000297579.5	+	4	1157	c.880G>T	c.(880-882)Ggc>Tgc	p.G294C	DCAF13_ENST00000521999.1_3'UTR|DCAF13_ENST00000521971.1_Missense_Mutation_p.G102C|DCAF13_ENST00000519682.1_Missense_Mutation_p.G138C	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	142					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GGATGGGCCAGGCTATGGAGA	0.318000													37	62					4.44401e-20	7.98056e-20	0.853193	1	0
GABRA5	2558	broad.mit.edu	37	15	27126036	27126036	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:27126036G>T	ENST00000335625.5	+	4	1018	c.130G>T	c.(130-132)Gac>Tac	p.D44Y	GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000400081.3_Missense_Mutation_p.D44Y|GABRA5_ENST00000355395.5_Missense_Mutation_p.D44Y|GABRA5_ENST00000557449.1_3'UTR	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	44					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAGACCAATGACAACATCAC	0.438000													6	18					0.000157383	0.000174438	0.278610	1	0
SLC17A1	6568	broad.mit.edu	37	6	25820093	25820093	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:25820093G>T	ENST00000244527.4	-	4	373	c.258C>A	c.(256-258)tcC>tcA	p.S86S	SLC17A1_ENST00000476801.1_Silent_p.S86S|SLC17A1_ENST00000468082.1_Silent_p.S86S|SLC17A1_ENST00000427328.1_Silent_p.S86S	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	86					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						CATAGGAGGTGGAACTCAAGA	0.408000													29	71					1.90571e-15	3.07067e-15	0.796494	1	0
RGS9	8787	broad.mit.edu	37	17	63200343	63200343	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:63200343C>A	ENST00000449996.3	+	15	1190	c.1118C>A	c.(1117-1119)aCa>aAa	p.T373K	RGS9_ENST00000262406.9_Missense_Mutation_p.T376K|RGS9_ENST00000443584.3_Missense_Mutation_p.T373K	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	376	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						ATGGACATCACAGTGAAGGGG	0.557000													27	52					1.02151e-06	1.23792e-06	0.769981	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768044	77768044	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:77768044G>T	ENST00000521891.2	+	10	9335	c.8887G>T	c.(8887-8889)Ggg>Tgg	p.G2963W	ZFHX4_ENST00000455469.2_Missense_Mutation_p.G2918W|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G2918W|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G2937W	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2918						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGAAATGTTAGGGAATGAGAT	0.423000										HNSCC(33;0.089)			7	26					0.00307968	0.00327455	0.278610	1	0
BCO2	83875	broad.mit.edu	37	11	112064282	112064282	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:112064282C>A	ENST00000357685.5	+	3	514	c.379C>A	c.(379-381)Cag>Aag	p.Q127K	SDHD_ENST00000532699.1_3'UTR|BCO2_ENST00000438022.1_Missense_Mutation_p.Q93K|BCO2_ENST00000532593.1_Missense_Mutation_p.Q22K|SDHD_ENST00000532612.1_3'UTR|BCO2_ENST00000531169.1_Missense_Mutation_p.Q93K|BCO2_ENST00000393032.2_Missense_Mutation_p.Q93K|BCO2_ENST00000361053.4_Missense_Mutation_p.Q127K|BCO2_ENST00000526088.1_Missense_Mutation_p.Q93K			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	127					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						CAAGTTTCTACAGAGTGATAC	0.448000													6	50					3.59834e-05	4.08202e-05	0.217242	1	0
HLF	3131	broad.mit.edu	37	17	53345303	53345303	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:53345303C>A	ENST00000226067.5	+	2	780	c.307C>A	c.(307-309)Cag>Aag	p.Q103K	HLF_ENST00000575345.1_Missense_Mutation_p.Q18K|HLF_ENST00000430986.2_Missense_Mutation_p.Q18K|HLF_ENST00000573945.1_Missense_Mutation_p.Q18K	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	103					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CAGCCCATCTCAGCATGACCA	0.587000			T	TCF3	ALL								127	54					1.5746e-79	3.59201e-79	0.870114	1	0
INTS4P2	644619	broad.mit.edu	37	7	65157731	65157731	+	RNA	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:65157731T>A	ENST00000430126.2	+	0	1058																											TGCTAAAACCTGTCCAACAAT	0.433000													11	126					0	0	0.500413	0	0
ACAD11	84129	broad.mit.edu	37	3	132295848	132295848	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:132295848C>A	ENST00000264990.6	-	16	2757	c.1786G>T	c.(1786-1788)Gga>Tga	p.G596*	ACAD11_ENST00000545291.1_Nonsense_Mutation_p.G121*|ACAD11_ENST00000355458.3_Intron	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						AAATGTCCTCCATGAAAATTA	0.289000													23	27					2.27525e-19	4.02446e-19	0.667858	1	0
GAS2	2620	broad.mit.edu	37	11	22777410	22777410	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:22777410G>T	ENST00000454584.2	+	7	939	c.634G>T	c.(634-636)Gat>Tat	p.D212Y	GAS2_ENST00000278187.3_Missense_Mutation_p.D212Y|GAS2_ENST00000433790.1_Missense_Mutation_p.D212Y	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	212	GAR.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AATTTCTGAAGATCCTCCTTG	0.438000													5	39					0.0381472	0.0391243	0.278610	1	0
EPS8L2	64787	broad.mit.edu	37	11	721611	721611	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:721611G>C	ENST00000533256.1	+	11	1190	c.815G>C	c.(814-816)cGg>cCg	p.R272P	EPS8L2_ENST00000530636.1_Missense_Mutation_p.R272P|EPS8L2_ENST00000526198.1_Missense_Mutation_p.R288P|AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Missense_Mutation_p.R272P			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	272						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTTGTGGCCCGGCTGCAGAAG	0.647000													4	23					0	0	0.150653	0	0
ATOH1	474	broad.mit.edu	37	4	94750358	94750358	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:94750358C>A	ENST00000306011.3	+	1	317	c.281C>A	c.(280-282)gCg>gAg	p.A94E		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	94					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GAGGCCGCTGCGCCCCGGGAC	0.706000													5	10					0.00116845	0.00125586	0.217242	1	0
RBM19	9904	broad.mit.edu	37	12	114395783	114395783	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:114395783A>G	ENST00000545145.2	-	6	722	c.644T>C	c.(643-645)aTg>aCg	p.M215T	RBM19_ENST00000261741.5_Missense_Mutation_p.M215T|RBM19_ENST00000392561.3_Missense_Mutation_p.M215T	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	215					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					AGCCTTCACCATCTTGGATTT	0.542000													14	117					0	0	0.435327	0	0
NID1	4811	broad.mit.edu	37	1	236141286	236141286	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:236141286G>T	ENST00000264187.6	-	20	3707	c.3625C>A	c.(3625-3627)Cat>Aat	p.H1209N	NID1_ENST00000366595.3_Missense_Mutation_p.H1076N	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	1209	EGF-like 6.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGTAGTTATGGCCTGGAAAA	0.522000													34	34					1.04594e-18	1.82265e-18	0.819951	1	0
OR8B3	390271	broad.mit.edu	37	11	124266866	124266866	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:124266866T>A	ENST00000354597.3	-	1	398	c.382A>T	c.(382-384)Aat>Tat	p.N128Y		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGCAATGGATTACAGATGGCC	0.458000													3	18					0	0	0.150653	0	0
BBX	56987	broad.mit.edu	37	3	107474505	107474505	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:107474505G>T	ENST00000415149.2	+	10	1213	c.886G>T	c.(886-888)Gca>Tca	p.A296S	BBX_ENST00000416476.2_Missense_Mutation_p.A296S|BBX_ENST00000402543.1_Missense_Mutation_p.A296S|BBX_ENST00000406780.1_Missense_Mutation_p.A296S|BBX_ENST00000325805.8_Missense_Mutation_p.A296S	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGGAAAGTCTGCACTCTTTCA	0.383000													47	174					5.19286e-32	1.06228e-31	0.870114	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42863360	42863360	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:42863360C>A	ENST00000455697.1	-	4	561	c.276G>T	c.(274-276)gaG>gaT	p.E92D	PRICKLE1_ENST00000345127.3_Missense_Mutation_p.E92D|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.E92D|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.E92D|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.E92D	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	92	PET.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CTTTTTTCTCCTCTTCACTCA	0.463000													12	27					7.93312e-07	9.63234e-07	0.457914	1	0
SOX21	11166	broad.mit.edu	37	13	95364140	95364140	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:95364140C>A	ENST00000376945.2	-	1	249	c.164G>T	c.(163-165)cGg>cTg	p.R55L		NM_007084.2	NP_009015.1	Q9Y651	SOX21_HUMAN	SRY (sex determining region Y)-box 21	55					regulation of transcription from RNA polymerase II promoter|stem cell differentiation	nucleus	DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	p.R55Q(1)		large_intestine(3)|lung(1)|prostate(1)|skin(1)	6	all_neural(89;0.0646)|Medulloblastoma(90;0.163)					GATGAACGGCCGCTTCTCCGA	0.627000													126	46					1.41203e-78	3.21723e-78	0.870114	1	0
PAQR9	344838	broad.mit.edu	37	3	142681339	142681339	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:142681339G>C	ENST00000340634.3	-	1	839	c.840C>G	c.(838-840)cgC>cgG	p.R280R		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	280						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						GCCAGAAGTAGCGGCGGTAGA	0.607000													25	46					0	0	0.750413	0	0
COL4A5	1287	broad.mit.edu	37	X	107821562	107821562	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:107821562G>T	ENST00000328300.6	+	13	973	c.729G>T	c.(727-729)caG>caT	p.Q243H	COL4A5_ENST00000361603.2_Missense_Mutation_p.Q243H	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	243	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CACCTGGGCAGATCAGTGAAC	0.428000									Alport syndrome with Diffuse Leiomyomatosis				17	70					3.10358e-05	3.54426e-05	0.624587	1	0
GRIN2B	2904	broad.mit.edu	37	12	14018943	14018943	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:14018943C>A	ENST00000279593.3	-	2	409	c.200G>T	c.(199-201)cGg>cTg	p.R67L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	67					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAGTTCCACCCGGGGTACCAC	0.552000													6	121					1.12685e-05	1.30266e-05	0.307466	1	0
KIT	3815	broad.mit.edu	37	4	55569935	55569935	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:55569935A>T	ENST00000288135.5	+	5	899	c.802A>T	c.(802-804)Aat>Tat	p.N268Y		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	268	Ig-like C2-type 3.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CGGTGACTTCAATTATGAACG	0.348000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				15	300					0	0	0.520397	0	0
MUC16	94025	broad.mit.edu	37	19	9084154	9084154	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:9084154G>C	ENST00000397910.4	-	1	7864	c.7661C>G	c.(7660-7662)tCc>tGc	p.S2554C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2554	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTAGCACTGGATCCAGTGAC	0.512000													55	12					0	0	0.870114	0	0
MS4A3	932	broad.mit.edu	37	11	59828636	59828636	+	Translation_Start_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:59828636G>C	ENST00000278865.3	+	2	76	c.3G>C	c.(1-3)atG>atC	p.M1I	MS4A3_ENST00000526199.1_3'UTR|MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000534744.1_Start_Codon_SNP_p.M1I|MS4A3_ENST00000358152.2_Start_Codon_SNP_p.M1I	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	1						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				CAACCCCAATGGCCTCCCACG	0.483000													13	32					0	0	0.520397	0	0
ADD2	119	broad.mit.edu	37	2	70915236	70915236	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:70915236G>T	ENST00000264436.3	-	9	1312	c.868C>A	c.(868-870)Cat>Aat	p.H290N	ADD2_ENST00000430656.1_Missense_Mutation_p.H306N|ADD2_ENST00000413157.2_Missense_Mutation_p.H290N|ADD2_ENST00000355733.3_Missense_Mutation_p.H290N|ADD2_ENST00000407644.2_Missense_Mutation_p.H290N|AC007395.3_ENST00000457851.1_RNA	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	290					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						ACCACTCCATGGTTTCTTAGC	0.413000													14	104					1.00905e-13	1.56298e-13	0.575678	1	0
PPP1R16B	26051	broad.mit.edu	37	20	37464808	37464808	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:37464808C>G	ENST00000299824.1	+	2	429	c.240C>G	c.(238-240)gaC>gaG	p.D80E	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.D80E|PPP1R16B_ENST00000468265.1_3'UTR	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	80					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				TGAGGAACGACGCCGAGGAAG	0.652000													9	42					0	0	0.335167	0	0
CNTN5	53942	broad.mit.edu	37	11	99690432	99690432	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:99690432G>C	ENST00000524871.1	+	4	503	c.213G>C	c.(211-213)ggG>ggC	p.G71G	CNTN5_ENST00000528682.1_Silent_p.G71G|CNTN5_ENST00000418526.2_Intron|CNTN5_ENST00000279463.3_Silent_p.G71G|CNTN5_ENST00000527185.1_Silent_p.G71G	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	71					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCTGGCTAGGGGCAGCTCAGA	0.433000													3	19					0	0	0.115264	0	0
NEU3	10825	broad.mit.edu	37	11	74716578	74716578	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:74716578C>T	ENST00000294064.4	+	3	1354	c.427C>T	c.(427-429)Cat>Tat	p.H143Y	NEU3_ENST00000545272.1_Missense_Mutation_p.H34Y|NEU3_ENST00000529024.1_Missense_Mutation_p.P72L|NEU3_ENST00000544263.1_Missense_Mutation_p.H110Y|NEU3_ENST00000532963.1_Missense_Mutation_p.P72L|NEU3_ENST00000531509.1_Missense_Mutation_p.H143Y	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	143										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						TGTGCGGGGCCATGTCACAGA	0.547000													20	59					0	0	0.608945	0	0
LPA	4018	broad.mit.edu	37	6	160978583	160978583	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:160978583C>A	ENST00000447678.1	-	30	4772	c.4652G>T	c.(4651-4653)tGc>tTc	p.C1551F	LPA_ENST00000316300.5_Missense_Mutation_p.C1551F	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4059	Kringle 14.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGATTCCTGCAGTAGTTCTC	0.478000													5	58					0.248553	0.250818	0.248553	1	0
BCAN	63827	broad.mit.edu	37	1	156615899	156615899	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:156615899C>A	ENST00000329117.4	+	2	389	c.53C>A	c.(52-54)cCt>cAt	p.P18H	BCAN_ENST00000361588.5_Missense_Mutation_p.P18H	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	18					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCCAGGCTCCTGCAGCTTTA	0.577000													8	49					0.0809354	0.0827828	0.387290	1	0
OPRM1	4988	broad.mit.edu	37	6	154360825	154360825	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:154360825G>T	ENST00000414028.2	+	1	196	c.146G>T	c.(145-147)cGc>cTc	p.R49L	OPRM1_ENST00000428397.2_Missense_Mutation_p.R49L|OPRM1_ENST00000452687.2_Missense_Mutation_p.R49L|OPRM1_ENST00000524163.1_Missense_Mutation_p.R49L|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000523520.1_3'UTR|OPRM1_ENST00000434900.2_Missense_Mutation_p.R142L|OPRM1_ENST00000419506.2_Missense_Mutation_p.R49L|OPRM1_ENST00000330432.7_Missense_Mutation_p.R49L|OPRM1_ENST00000435918.2_Missense_Mutation_p.R49L|OPRM1_ENST00000337049.4_Missense_Mutation_p.R49L|OPRM1_ENST00000360422.4_Missense_Mutation_p.R49L|OPRM1_ENST00000229768.5_Missense_Mutation_p.R49L|OPRM1_ENST00000520708.1_Intron	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	49					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding	p.R49H(2)|p.R142H(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GGTCCGAACCGCACCGACCTG	0.637000													6	41					0.00448238	0.0047419	0.307466	1	0
LRFN1	57622	broad.mit.edu	37	19	39805739	39805739	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:39805739C>A	ENST00000248668.4	-	1	237	c.238G>T	c.(238-240)Gtg>Ttg	p.V80L	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	80						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGGCGGCGCACGGCGGCGATG	0.672000													13	16					0.000422831	0.000464276	0.500413	1	0
FLT3	2322	broad.mit.edu	37	13	28626686	28626686	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:28626686C>A	ENST00000380982.4	-	5	691	c.610G>T	c.(610-612)Gaa>Taa	p.E204*	FLT3_ENST00000537084.1_Nonsense_Mutation_p.E204*|FLT3_ENST00000241453.7_Nonsense_Mutation_p.E204*			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	204					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCATACCTTTCCCCCTGTGAA	0.418000			"""Mis, O"""		"""AML, ALL"""								15	38					3.41278e-10	4.73662e-10	0.520397	1	0
BMS1	9790	broad.mit.edu	37	10	43315873	43315873	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:43315873G>T	ENST00000374518.4	+	16	2832		c.e16+1			NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CTACGTGCAGGTGGGTCCCTT	0.498000													29	29					7.11191e-15	1.1295e-14	0.769981	1	0
TMEM151A	256472	broad.mit.edu	37	11	66063045	66063045	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:66063045A>T	ENST00000327259.4	+	2	1472	c.1328A>T	c.(1327-1329)tAt>tTt	p.Y443F		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	443						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						CCGCCCTGCTATGAGGACGCC	0.726000													5	25					0	0	0.217242	0	0
RAB27B	5874	broad.mit.edu	37	18	52544851	52544851	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:52544851T>A	ENST00000262094.5	+	2	556	c.35T>A	c.(34-36)cTc>cAc	p.L12H	RAB27B_ENST00000586594.1_3'UTR	NM_004163.4	NP_004154.2	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	12					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity			large_intestine(3)|lung(3)|skin(1)	7				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CTGATCAAACTCCTGGCCCTC	0.393000													13	13					0	0	0.479597	0	0
UMOD	7369	broad.mit.edu	37	16	20359587	20359587	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:20359587C>A	ENST00000396134.2	-	5	1153	c.1030G>T	c.(1030-1032)Ggc>Tgc	p.G344C	UMOD_ENST00000302509.4_Missense_Mutation_p.G311C|UMOD_ENST00000424589.1_Missense_Mutation_p.G344C|UMOD_ENST00000396138.4_Missense_Mutation_p.G360C|UMOD_ENST00000396142.2_Missense_Mutation_p.G311C|UMOD_ENST00000570689.1_Missense_Mutation_p.G311C	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	311	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TGCCATCTGCCATTATTCGAT	0.557000													25	226					2.47316e-13	3.79648e-13	0.779181	1	0
PAX6	5080	broad.mit.edu	37	11	31815208	31815208	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:31815208G>A	ENST00000419022.1	-	11	1418	c.950C>T	c.(949-951)aCc>aTc	p.T317I	PAX6_ENST00000379111.2_Missense_Mutation_p.T303I|PAX6_ENST00000379123.5_Missense_Mutation_p.T303I|PAX6_ENST00000241001.8_Missense_Mutation_p.T303I|PAX6_ENST00000379129.2_Missense_Mutation_p.T317I|PAX6_ENST00000379132.3_Missense_Mutation_p.T303I|PAX6_ENST00000379107.2_Missense_Mutation_p.T317I|PAX6_ENST00000379115.4_Missense_Mutation_p.T317I	NM_001127612.1|NM_001258462.1|NM_001258463.1	NP_001121084.1|NP_001245391.1|NP_001245392.1	P26367	PAX6_HUMAN	paired box 6	303	Pro/Ser/Thr-rich.			R -> L (in Ref. 1; AAA59962).	blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)	35	Lung SC(675;0.225)					ACCCGGTGTGGTGGGTTGTGG	0.443000									Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation				60	132					0	0	0.870114	0	0
CD177	57126	broad.mit.edu	37	19	43859677	43859677	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:43859677G>T	ENST00000378009.4	+	0	421				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				ATCCCATGATGGGAGCTGCAG	0.522000													3	4					2.56e-06	3.05318e-06	0.150653	1	0
IGLV3-22	28795	broad.mit.edu	37	22	23047026	23047026	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:23047026G>T	ENST00000390307.2	+	0	128																											TGCCTCCTATGAGCTGACACA	0.547000													26	96					1.2476e-16	2.07236e-16	0.706142	1	0
WDR1	9948	broad.mit.edu	37	4	10089384	10089384	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:10089384A>C	ENST00000382452.2	-	8	1180	c.898T>G	c.(898-900)Tac>Gac	p.Y300D	WDR1_ENST00000515743.1_5'UTR|WDR1_ENST00000502702.1_Missense_Mutation_p.Y160D|WDR1_ENST00000382451.2_Missense_Mutation_p.Y160D|WDR1_ENST00000499869.2_Missense_Mutation_p.Y300D	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	300					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TAGTTGATGTACCCGGACAGG	0.607000													3	5					0	0	0.115264	0	0
VGLL3	389136	broad.mit.edu	37	3	87039778	87039778	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:87039778G>T	ENST00000398399.2	-	1	479	c.116C>A	c.(115-117)cCt>cAt	p.P39H	VGLL3_ENST00000383698.3_Missense_Mutation_p.P39H	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CTGCTGGCCAGGTTGGGGCGC	0.682000													16	29					2.89027e-11	4.15863e-11	0.624587	1	0
EPHA4	2043	broad.mit.edu	37	2	222322708	222322708	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:222322708G>A	ENST00000281821.2	-	6	1362	c.1321C>T	c.(1321-1323)Cca>Tca	p.P441S	EPHA4_ENST00000409938.1_Missense_Mutation_p.P441S|EPHA4_ENST00000409854.1_Missense_Mutation_p.P441S|EPHA4_ENST00000392071.4_Missense_Mutation_p.P390S	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	441	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		ATGGATGATGGTGCTGTTAGA	0.383000													11	50					0	0	0.435327	0	0
CD109	135228	broad.mit.edu	37	6	74407146	74407146	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:74407146C>T	ENST00000437994.2	+	2	529	c.98C>T	c.(97-99)cCa>cTa	p.P33L	CD109_ENST00000422508.2_Missense_Mutation_p.P33L|CD109_ENST00000287097.5_Missense_Mutation_p.P33L	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	33						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGACAGCCCCAGGGATCATC	0.507000													101	38					0	0	0.870114	0	0
KIRREL	55243	broad.mit.edu	37	1	158064642	158064642	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158064642G>T	ENST00000368172.1	+	11	1460	c.1448G>T	c.(1447-1449)gGc>gTc	p.G483V	KIRREL_ENST00000368173.3_Missense_Mutation_p.G685V|KIRREL_ENST00000416935.2_Missense_Mutation_p.G569V|KIRREL_ENST00000392272.2_Missense_Mutation_p.G566V|KIRREL_ENST00000359209.6_Missense_Mutation_p.G669V|KIRREL_ENST00000360089.4_Missense_Mutation_p.G505V			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	669	Ig-like C2-type 5.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					ACACCCCCTGGCCCTGCTGCC	0.642000													19	42					5.35356e-11	7.65026e-11	0.639603	1	0
HIST1H3G	8355	broad.mit.edu	37	6	26271400	26271400	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:26271400C>T	ENST00000305910.3	-	1	212	c.213G>A	c.(211-213)ctG>ctA	p.L71L		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	71					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						TTTCTCGCACCAGGCGTTGGA	0.602000													73	59					0	0	0.870114	0	0
C3orf20	84077	broad.mit.edu	37	3	14744727	14744727	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:14744727G>T	ENST00000253697.3	+	6	1288	c.836G>T	c.(835-837)tGc>tTc	p.C279F	C3orf20_ENST00000435614.1_Missense_Mutation_p.C157F|C3orf20_ENST00000412910.1_Missense_Mutation_p.C157F	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	279						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGCGACCCCTGCCCTGAGGCC	0.607000													38	84					1.15183e-24	2.21425e-24	0.847076	1	0
LPPR4	9890	broad.mit.edu	37	1	99771917	99771917	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:99771917C>A	ENST00000370185.3	+	7	2140	c.1643C>A	c.(1642-1644)cCc>cAc	p.P548H	LPPR4_ENST00000457765.1_Missense_Mutation_p.P490H|LPPR4_ENST00000370184.1_Missense_Mutation_p.P390H	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		548							phosphatidate phosphatase activity	p.P548L(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGCACCTCCCCCAAAAGCAGC	0.547000													28	68					2.24059e-21	4.12199e-21	0.706142	1	0
GRXCR2	643226	broad.mit.edu	37	5	145239475	145239475	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:145239475C>A	ENST00000377976.1	-	3	567	c.568G>T	c.(568-570)Ggg>Tgg	p.G190W		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	190										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						GGAATATCCCCTTCCTGCAAG	0.537000													17	5					1.2644e-06	1.52948e-06	0.592651	1	0
AFF2	2334	broad.mit.edu	37	X	148035269	148035269	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:148035269G>T	ENST00000370460.2	+	10	2036	c.1557_splice	c.e10+1	p.E519_splice	AFF2_ENST00000342251.3_Splice_Site_p.E486_splice|AFF2_ENST00000370457.5_Splice_Site_p.E486_splice|AFF2_ENST00000286437.5_Splice_Site_p.E160_splice	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	519					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAACTCCAGAGGTGAGTGAAG	0.547000													15	126					2.94398e-08	3.78972e-08	0.557998	1	0
ZNF180	7733	broad.mit.edu	37	19	44981682	44981682	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:44981682G>T	ENST00000221327.4	-	5	1297	c.1016C>A	c.(1015-1017)tCc>tAc	p.S339Y	ZNF180_ENST00000592529.1_Missense_Mutation_p.S312Y|ZNF180_ENST00000391956.4_Missense_Mutation_p.S314Y	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				TTGAGTAAGGGAGGAACTATG	0.388000													76	71					7.62596e-35	1.59114e-34	0.870114	1	0
IGSF22	283284	broad.mit.edu	37	11	18735841	18735841	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:18735841G>T	ENST00000513874.1	-	13	1920	c.1781C>A	c.(1780-1782)gCc>gAc	p.A594D	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	594										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						GAATACAGAGGCTTCACTTTC	0.567000													8	25					3.86212e-05	4.36547e-05	0.361761	1	0
HIC2	23119	broad.mit.edu	37	22	21800462	21800462	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:21800462G>A	ENST00000443632.2	+	2	1650	c.1278G>A	c.(1276-1278)atG>atA	p.M426I	HIC2_ENST00000407598.2_Missense_Mutation_p.M426I|HIC2_ENST00000407464.2_Missense_Mutation_p.M426I			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	426					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CCCACTACATGTACCGGCAGG	0.632000													15	288					0	0	0.624587	0	0
PLCL2	23228	broad.mit.edu	37	3	17131310	17131310	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:17131310T>G	ENST00000418129.2	+	6	3377	c.2912T>G	c.(2911-2913)cTg>cGg	p.L971R	PLCL2_ENST00000432376.1_Missense_Mutation_p.L971R	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1097					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TCATGTGGACTGAATAAACCA	0.423000													12	33					0	0	0.457914	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629753	9629753	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:9629753A>G	ENST00000382492.2	-	1	710	c.392T>C	c.(391-393)cTg>cCg	p.L131P	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	131					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						CAGAGACCCCAGGATCATCCA	0.458000													9	93					0	0	0.387290	0	0
GPRASP1	9737	broad.mit.edu	37	X	101911008	101911008	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:101911008T>A	ENST00000537097.1	+	6	2980	c.2167T>A	c.(2167-2169)Tgg>Agg	p.W723R	RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Missense_Mutation_p.W723R|GPRASP1_ENST00000415986.1_Missense_Mutation_p.W723R|GPRASP1_ENST00000444152.1_Missense_Mutation_p.W723R	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	723	Glu-rich.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TATAGGGTCCTGGTTATGGGC	0.458000													17	137					0	0	0.575678	0	0
OR4C6	219432	broad.mit.edu	37	11	55432954	55432954	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55432954C>A	ENST00000314259.3	+	1	341	c.312C>A	c.(310-312)ttC>ttA	p.F104L		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGGAGCATTTCTTTGGTGGTG	0.542000													8	73					3.07112e-06	3.6397e-06	0.387290	1	0
DNAH5	1767	broad.mit.edu	37	5	13820519	13820519	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:13820519C>A	ENST00000265104.4	-	41	6881	c.6777G>T	c.(6775-6777)atG>atT	p.M2259I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2259	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCCCCAGAGTCATCATCCCAT	0.537000									Kartagener syndrome				19	147					6.94344e-10	9.5106e-10	0.539581	1	0
OR51E2	81285	broad.mit.edu	37	11	4703890	4703890	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4703890C>A	ENST00000396950.3	-	2	291	c.52G>T	c.(52-54)Gga>Tga	p.G18*		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTCTCTAATCCTGGGATACCA	0.507000													7	67					2.0095e-06	2.40577e-06	0.248553	1	0
ZFHX4	79776	broad.mit.edu	37	8	77616893	77616893	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:77616893G>T	ENST00000521891.2	+	2	1018	c.570G>T	c.(568-570)caG>caT	p.Q190H	ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q190H|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q190H|ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q190H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTACCCACAGATCATCAACA	0.478000										HNSCC(33;0.089)			23	24					2.27525e-19	4.02446e-19	0.667858	1	0
DPYSL4	10570	broad.mit.edu	37	10	134012450	134012450	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:134012450C>G	ENST00000338492.4	+	8	950	c.786C>G	c.(784-786)gaC>gaG	p.D262E	DPYSL4_ENST00000368627.1_Missense_Mutation_p.D162E|DPYSL4_ENST00000368629.1_Missense_Mutation_p.D162E	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	262					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GGGCGGCCGACGCCATCGCTC	0.677000													25	26					0	0	0.717897	0	0
RECK	8434	broad.mit.edu	37	9	36091208	36091208	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:36091208G>T	ENST00000377966.3	+	10	1519	c.953G>T	c.(952-954)aGt>aTt	p.S318I		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	318	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			AATACACAGAGTTGGCAAGAG	0.458000													35	167					7.63091e-17	1.27543e-16	0.834066	1	0
EID3	493861	broad.mit.edu	37	12	104697914	104697914	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:104697914G>T	ENST00000527879.1	+	1	398	c.202G>T	c.(202-204)Gag>Tag	p.E68*	TXNRD1_ENST00000378070.4_Intron|TXNRD1_ENST00000354940.6_Intron|TXNRD1_ENST00000542918.1_Intron|TXNRD1_ENST00000540716.1_Intron|TXNRD1_ENST00000529546.1_Intron|TXNRD1_ENST00000388854.3_Intron|TXNRD1_ENST00000526691.1_Intron|TXNRD1_ENST00000526390.1_Intron|TXNRD1_ENST00000525566.1_Intron|TXNRD1_ENST00000524698.1_Intron|TXNRD1_ENST00000503506.2_Intron|TXNRD1_ENST00000429002.2_Intron|TXNRD1_ENST00000397736.2_Intron	NM_001008394.2	NP_001008395.1	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation 3	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CTCCTTAACCGAGGCTCTGGA	0.587000													19	48					2.98393e-07	3.70188e-07	0.639603	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768056	77768056	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:77768056G>T	ENST00000521891.2	+	10	9347	c.8899G>T	c.(8899-8901)Ggt>Tgt	p.G2967C	ZFHX4_ENST00000455469.2_Missense_Mutation_p.G2922C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G2922C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G2941C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2922						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAATGAGATTGGTCTGCCCAA	0.418000										HNSCC(33;0.089)			5	23					0.000602214	0.000654747	0.184627	1	0
PCDHB4	56131	broad.mit.edu	37	5	140503780	140503780	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140503780C>A	ENST00000194152.1	+	1	2200	c.2200C>A	c.(2200-2202)Cat>Aat	p.H734N		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		734					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTCCAGGGCATCTGGTGGA	0.647000													64	56					9.4991e-31	1.92851e-30	0.870114	1	0
SYNPO2	171024	broad.mit.edu	37	4	119951001	119951001	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:119951001G>T	ENST00000307142.4	+	4	1267	c.1069_splice	c.e4-1	p.R357_splice	SYNPO2_ENST00000429713.2_Splice_Site_p.R357_splice|SYNPO2_ENST00000434046.2_Splice_Site_p.R357_splice|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	357						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TTTCCCTAGGGCTCAGGAGGA	0.408000													13	60					1.49906e-05	1.72026e-05	0.457914	1	0
AGPAT4	56895	broad.mit.edu	37	6	161574506	161574506	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:161574506C>T	ENST00000320285.4	-	5	748	c.536G>A	c.(535-537)cGg>cAg	p.R179Q	AGPAT4_ENST00000457520.2_Intron|AGPAT4_ENST00000366908.5_3'UTR|AGPAT4_ENST00000366911.5_3'UTR	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	179					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CTCCGTGAACCGTGTGCCCTC	0.632000													3	11					0	0	0.150653	0	0
GSG2	83903	broad.mit.edu	37	17	3627256	3627256	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:3627256G>T	ENST00000325418.4	+	1	46	c.27G>T	c.(25-27)ggG>ggT	p.G9G	ITGAE_ENST00000263087.4_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	9					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										CGGGACCTGGGAGCCGGCTTT	0.721000													5	28					1.23904e-05	1.42622e-05	0.184627	1	0
MIR296	407022	broad.mit.edu	37	20	57392720	57392720	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:57392720G>A	ENST00000385215.1	-	0	29					NR_029844.1																						GGCACAACAGGATTGAGGGGG	0.577000													23	39					0	0	0.717897	0	0
SI	6476	broad.mit.edu	37	3	164755784	164755784	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:164755784C>A	ENST00000264382.3	-	21	2392	c.2330G>T	c.(2329-2331)cGg>cTg	p.R777L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	777	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CATATCAACCCGTTGTTTCCT	0.333000										HNSCC(35;0.089)			21	50					1.77063e-15	2.85792e-15	0.693898	1	0
RP1L1	94137	broad.mit.edu	37	8	10468341	10468341	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:10468341C>T	ENST00000382483.3	-	4	3490	c.3267G>A	c.(3265-3267)ctG>ctA	p.L1089L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1089					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGGAGCCCATCAGCGCCCTCA	0.682000													8	28					0	0	0.307466	0	0
MCMDC2	157777	broad.mit.edu	37	8	67803242	67803242	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:67803242G>C	ENST00000422365.2	+	10	1387	c.1216G>C	c.(1216-1218)Ggt>Cgt	p.G406R	MCMDC2_ENST00000541540.1_Missense_Mutation_p.G343R|MCMDC2_ENST00000313616.5_Missense_Mutation_p.G406R|MCMDC2_ENST00000396592.3_Missense_Mutation_p.G406R	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	406					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						AGCTAAAGGTGGTATCTGCTT	0.368000													15	35					0	0	0.520397	0	0
KCNH8	131096	broad.mit.edu	37	3	19436773	19436773	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:19436773G>C	ENST00000328405.2	+	7	1413	c.1147G>C	c.(1147-1149)Gaa>Caa	p.E383Q	KCNH8_ENST00000537696.1_Missense_Mutation_p.E24Q	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	383						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						AATGGAGAGGGAAGACAACAG	0.418000													13	35					0	0	0.500413	0	0
CAPN6	827	broad.mit.edu	37	X	110495659	110495659	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:110495659G>T	ENST00000324068.1	-	5	742	c.575C>A	c.(574-576)aCa>aAa	p.T192K	CAPN6_ENST00000541758.1_Intron	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	192	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TTCAGCCAATGTGCCCGTGAA	0.438000													21	65					3.01185e-09	4.04589e-09	0.667858	1	0
OPCML	4978	broad.mit.edu	37	11	132306087	132306087	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:132306087C>G	ENST00000331898.7	-	6	1408	c.830G>C	c.(829-831)cGc>cCc	p.R277P	OPCML_ENST00000524381.1_Missense_Mutation_p.R270P|OPCML_ENST00000541867.1_Missense_Mutation_p.R277P|OPCML_ENST00000374778.4_Missense_Mutation_p.R236P|OPCML_ENST00000529038.1_5'UTR	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	277	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		AGTGGACATGCGGCCTTTGTT	0.458000													14	101					0	0	0.500413	0	0
MYO1A	4640	broad.mit.edu	37	12	57423576	57423576	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:57423576C>A	ENST00000442789.2	-	26	2959	c.2672G>T	c.(2671-2673)gGg>gTg	p.G891V	MYO1A_ENST00000544473.1_Missense_Mutation_p.G729V|MYO1A_ENST00000300119.3_Missense_Mutation_p.G891V	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	891					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						CAGAACAGGCCCCTCCTCCCC	0.582000													51	75					2.5401e-28	5.0748e-28	0.870114	1	0
ADCYAP1R1	117	broad.mit.edu	37	7	31104527	31104527	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:31104527G>A	ENST00000304166.4	+	3	421	c.132G>A	c.(130-132)ctG>ctA	p.L44L	ADCYAP1R1_ENST00000396211.2_Silent_p.L44L|ADCYAP1R1_ENST00000409489.1_Silent_p.L44L|ADCYAP1R1_ENST00000409363.1_Silent_p.L44L	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	44					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CCAATGAGCTGATGGGCTTCA	0.567000													17	18					0	0	0.575678	0	0
FAT2	2196	broad.mit.edu	37	5	150948228	150948228	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:150948228C>A	ENST00000261800.5	-	1	277	c.265G>T	c.(265-267)Gtg>Ttg	p.V89L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	89	Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGTTGCCCACCACATACTCC	0.512000													435	245					1.43351e-237	3.3062e-237	0.870114	1	0
PKHD1	5314	broad.mit.edu	37	6	51824799	51824799	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:51824799C>A	ENST00000371117.3	-	36	6052	c.5777G>T	c.(5776-5778)cGg>cTg	p.R1926L	PKHD1_ENST00000340994.4_Missense_Mutation_p.R1926L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1926					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GGACCATCTCCGGCAGAACTG	0.527000											OREG0017492	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	94					6.31663e-08	8.01611e-08	0.479597	1	0
DCDC1	341019	broad.mit.edu	37	11	30915864	30915864	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:30915864C>A	ENST00000597505.1	-	33	4823	c.4824G>T	c.(4822-4824)gtG>gtT	p.V1608V	DCDC1_ENST00000406071.2_Silent_p.V346V			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					CTCCTTCAACCACCACGGGCT	0.478000													19	42					4.96729e-08	6.32934e-08	0.575678	1	0
CSMD2	114784	broad.mit.edu	37	1	34035017	34035017	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:34035017G>A	ENST00000373381.4	-	52	8264	c.8088C>T	c.(8086-8088)tgC>tgT	p.C2696C		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2698	Sushi 17.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATTGGCCATGCACTCACGCA	0.557000													25	76					0	0	0.740014	0	0
CLNK	116449	broad.mit.edu	37	4	10542187	10542187	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:10542187G>T	ENST00000226951.6	-	11	772	c.533C>A	c.(532-534)cCt>cAt	p.P178H	CLNK_ENST00000507719.1_Missense_Mutation_p.P136H|CLNK_ENST00000442825.2_Missense_Mutation_p.P136H	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	178	Mediates interaction with LAT and GRB2 (By similarity).|Pro-rich.				immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						CTCCGGCTCAGGGGGCAAGGG	0.527000													20	29					2.70639e-06	3.22369e-06	0.624587	1	0
TNR	7143	broad.mit.edu	37	1	175334349	175334349	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:175334349C>A	ENST00000367674.1	-	12	3092	c.2384G>T	c.(2383-2385)aGt>aTt	p.S795I	TNR_ENST00000263525.2_Missense_Mutation_p.S795I	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	795	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AGATGGATCACTCCAAGTGAT	0.517000													19	48					8.10497e-08	1.02579e-07	0.592651	1	0
CHDH	55349	broad.mit.edu	37	3	53852965	53852965	+	Splice_Site	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:53852965C>T	ENST00000315251.5	-	8	1803	c.1366_splice	c.e8+1	p.E456_splice		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	456					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	GGTGAAGTACCTGTTGACAAG	0.532000													11	70					0	0	0.411799	0	0
PCDH15	65217	broad.mit.edu	37	10	55943255	55943255	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:55943255G>T	ENST00000373965.2	-	14	1954	c.1560C>A	c.(1558-1560)tcC>tcA	p.S520S	PCDH15_ENST00000395430.1_Silent_p.S513S|PCDH15_ENST00000437009.1_Silent_p.S513S|PCDH15_ENST00000373955.1_Silent_p.S513S|PCDH15_ENST00000414778.1_Silent_p.S518S|PCDH15_ENST00000373957.3_Silent_p.S491S|PCDH15_ENST00000395432.2_Silent_p.S476S|PCDH15_ENST00000409834.1_Silent_p.S124S|PCDH15_ENST00000395446.1_Silent_p.S513S|PCDH15_ENST00000395438.1_Silent_p.S513S|PCDH15_ENST00000395433.1_Silent_p.S491S|PCDH15_ENST00000320301.6_Silent_p.S513S|PCDH15_ENST00000395445.1_Silent_p.S520S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000361849.3_Silent_p.S513S|PCDH15_ENST00000395440.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	513	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACACATCATAGGATATTTCAG	0.383000										HNSCC(58;0.16)			10	52					3.86212e-05	4.36547e-05	0.361761	1	0
IFT172	26160	broad.mit.edu	37	2	27688304	27688304	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:27688304C>A	ENST00000260570.3	-	18	2014	c.1911G>T	c.(1909-1911)gaG>gaT	p.E637D		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	637					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTTGCCTTGCCTCTAGTGCCA	0.498000													15	95					0.000566183	0.00061915	0.520397	1	0
ADAM28	10863	broad.mit.edu	37	8	24168935	24168935	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:24168935C>G	ENST00000265769.4	+	5	478	c.368C>G	c.(367-369)aCa>aGa	p.T123R	RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000540823.1_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000437154.2_Missense_Mutation_p.T123R|ADAM28_ENST00000397649.3_5'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	123					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGCATCAGCACATGTAGGGGT	0.363000													9	43					0	0	0.361761	0	0
IPP	3652	broad.mit.edu	37	1	46193421	46193421	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:46193421G>A	ENST00000396478.3	-	5	1032	c.930C>T	c.(928-930)ctC>ctT	p.L310L		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	310						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					CTACACAGCTGAGGGCTCTGC	0.473000													35	128					0	0	0.847076	0	0
ABCA7	10347	broad.mit.edu	37	19	1056422	1056422	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:1056422G>T	ENST00000263094.6	+	33	4741	c.4510G>T	c.(4510-4512)Gcc>Tcc	p.A1504S	ABCA7_ENST00000435683.2_Missense_Mutation_p.A1366S|ABCA7_ENST00000433129.1_Missense_Mutation_p.A1504S	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1504					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGCCCGGCCCGCCACGC	0.617000													41	17					6.75472e-32	1.37878e-31	0.870114	1	0
ERVFRD-1	405754	broad.mit.edu	37	6	11104926	11104926	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:11104926C>A	ENST00000472091.1	-	2	993	c.618G>T	c.(616-618)tgG>tgT	p.W206C	SMIM13_ENST00000416247.2_Intron|ERVFRD-1_ENST00000542862.1_Missense_Mutation_p.W206C	NM_207582.2	NP_997465.1	P60508	EFRD1_HUMAN		206						integral to membrane|plasma membrane|virion				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(4)|stomach(1)	15						CAGGCCGGAACCAGAAGTTTC	0.458000													17	118					4.7546e-09	6.31933e-09	0.500413	1	0
OR4C12	283093	broad.mit.edu	37	11	50003624	50003624	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:50003624C>T	ENST00000335238.4	-	1	447	c.414G>A	c.(412-414)ctG>ctA	p.L138L		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						GGAGAATGCACAGGCTGTGGC	0.507000													30	286					0	0	0.788014	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323257	61323257	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:61323257C>T	ENST00000283752.5	-	8	950	c.807G>A	c.(805-807)tgG>tgA	p.W269*	SERPINB3_ENST00000332821.8_Nonsense_Mutation_p.W217*|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	269					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						GCAAACTTGTCCATTCCATCA	0.388000													12	15					0	0	0.520397	0	0
PRMT5	10419	broad.mit.edu	37	14	23395765	23395765	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:23395765C>G	ENST00000324366.8	-	6	787		c.e6-1		PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000216350.8_Splice_Site|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5_ENST00000397440.4_Intron|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5_ENST00000553641.1_Splice_Site|PRMT5_ENST00000553897.1_Splice_Site|PRMT5_ENST00000397441.2_Splice_Site|PRMT5_ENST00000538452.1_Splice_Site	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5						cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GTTGTGCCACCTGTTCAGTCA	0.493000													33	159					0	0	0.796494	0	0
USH2A	7399	broad.mit.edu	37	1	216348733	216348733	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:216348733G>C	ENST00000366943.2	-	21	4874	c.4488C>G	c.(4486-4488)ccC>ccG	p.P1496P	USH2A_ENST00000366942.3_Silent_p.P1496P|USH2A_ENST00000307340.3_Silent_p.P1496P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1496					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATATAGGAGAGGGTCCATTCA	0.433000										HNSCC(13;0.011)			22	32					0	0	0.654019	0	0
SMO	6608	broad.mit.edu	37	7	128851597	128851597	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:128851597C>G	ENST00000249373.3	+	11	2202	c.1922C>G	c.(1921-1923)cCt>cGt	p.P641R	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	641					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TCTGTCACCCCTGTGGCAACT	0.597000			Mis		skin basal cell								39	71					0	0	0.870114	0	0
CDYL	9425	broad.mit.edu	37	6	4892414	4892414	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:4892414G>T	ENST00000328908.5	+	4	785	c.654G>T	c.(652-654)gaG>gaT	p.E218D	CDYL_ENST00000472453.1_Intron|CDYL_ENST00000449732.2_Missense_Mutation_p.E32D|CDYL_ENST00000343762.5_Missense_Mutation_p.E32D|CDYL_ENST00000397588.3_Missense_Mutation_p.E164D			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	218					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		AGAGCCCTGAGAAACTGGACC	0.602000													14	24					4.3838e-07	5.36431e-07	0.435327	1	0
ASTL	431705	broad.mit.edu	37	2	96801132	96801132	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:96801132G>T	ENST00000342380.2	-	3	200	c.201C>A	c.(199-201)acC>acA	p.T67T		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	67					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						TGCTCTCTGGGGTTTCTTCCA	0.587000													13	44					6.49762e-13	9.79849e-13	0.539581	1	0
ZNF816	125893	broad.mit.edu	37	19	53454766	53454766	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:53454766C>A	ENST00000357666.4	-	5	562	c.262G>T	c.(262-264)Ggg>Tgg	p.G88W	ZNF816_ENST00000444460.2_Missense_Mutation_p.G88W|ZNF816_ENST00000434371.2_Intron|ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000391786.2_3'UTR	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	88	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						TGCAACGTCCCTGTGTGGATC	0.373000													11	70					6.72482e-11	9.57346e-11	0.479597	1	0
MMP16	4325	broad.mit.edu	37	8	89180196	89180196	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:89180196C>A	ENST00000286614.6	-	4	692	c.411G>T	c.(409-411)aaG>aaT	p.K137N	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	137					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GAGTTACGTTCTTTATACTGA	0.348000													13	34					4.7546e-09	6.31933e-09	0.500413	1	0
KCNK9	51305	broad.mit.edu	37	8	140630537	140630537	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:140630537G>T	ENST00000520439.1	-	2	1152	c.1089C>A	c.(1087-1089)gaC>gaA	p.D363E	KCNK9_ENST00000303015.1_Missense_Mutation_p.D363E			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	363						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GCCTCTGGTGGTCGGTAAAGC	0.473000													45	140					2.17126e-26	4.23891e-26	0.870114	1	0
THOC2	57187	broad.mit.edu	37	X	122765684	122765684	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:122765684T>A	ENST00000245838.8	-	22	2367	c.2336A>T	c.(2335-2337)cAg>cTg	p.Q779L	THOC2_ENST00000355725.4_Missense_Mutation_p.Q779L|THOC2_ENST00000491737.1_Missense_Mutation_p.Q664L	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	779					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						CCCACCAAACTGCACCAGGGT	0.313000													27	130					0	0	0.769981	0	0
DUSP27	92235	broad.mit.edu	37	1	167095239	167095239	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:167095239G>T	ENST00000361200.2	+	6	1037	c.871G>T	c.(871-873)Gga>Tga	p.G291*	DUSP27_ENST00000443333.1_Nonsense_Mutation_p.G291*|DUSP27_ENST00000271385.5_Nonsense_Mutation_p.G291*|DUSP27_ENST00000485151.1_3'UTR			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	291					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCGGGAGGGGGGATCAGCTGA	0.637000													8	35					0.000157383	0.000174438	0.278610	1	0
MYH6	4624	broad.mit.edu	37	14	23855701	23855701	+	Silent	SNP	C	C	A	rs142823394	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:23855701C>A	ENST00000405093.3	-	33	4852	c.4782G>T	c.(4780-4782)cgG>cgT	p.R1594R	MYH6_ENST00000356287.3_Silent_p.R1594R	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1594					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGTCCACCACCCGCTGGTGGT	0.592000													74	174					8.2577e-42	1.78838e-41	0.870114	1	0
TBRG4	9238	broad.mit.edu	37	7	45141999	45141999	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:45141999C>A	ENST00000258770.3	-	7	1389	c.1268G>T	c.(1267-1269)cGg>cTg	p.R423L	TBRG4_ENST00000361278.3_Missense_Mutation_p.R313L|TBRG4_ENST00000494076.1_Missense_Mutation_p.R423L|TBRG4_ENST00000395655.4_Missense_Mutation_p.R313L	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	423					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						CTCTGCTTCCCGTGCCTGCTG	0.607000													29	67					3.67414e-24	7.02003e-24	0.760397	1	0
P2RY10	27334	broad.mit.edu	37	X	78216351	78216351	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:78216351C>A	ENST00000171757.2	+	4	614	c.334C>A	c.(334-336)Ctg>Atg	p.L112M	P2RY10_ENST00000544091.1_Missense_Mutation_p.L112M|P2RY10_ENST00000475374.1_3'UTR	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	112						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CTGCTTCTACCTGAAGTATCT	0.483000													16	61					0.000295444	0.000324781	0.624587	1	0
TAF3	83860	broad.mit.edu	37	10	8007183	8007183	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:8007183G>T	ENST00000344293.5	+	3	1916	c.1710G>T	c.(1708-1710)agG>agT	p.R570S		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	570	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						aAACTGGCAGGGAAACAAAGT	0.378000													10	46					0.000673444	0.000729241	0.361761	1	0
PLCXD1	55344	broad.mit.edu	37	X	208264	208264	+	Silent	SNP	C	C	T	rs149046110	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:208264C>T	ENST00000381657.2	+	5	1006	c.492C>T	c.(490-492)caC>caT	p.H164H	PLCXD1_ENST00000381663.3_Silent_p.H164H|PLCXD1_ENST00000399012.1_Silent_p.H164H	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	164	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGACCTGCACGAGTACCTGG	0.617000													29	62					0	0	0.788014	0	0
DCAF6	55827	broad.mit.edu	37	1	168034951	168034951	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:168034951G>T	ENST00000367840.3	+	19	2657	c.2563G>T	c.(2563-2565)Gta>Tta	p.V855L	DCAF6_ENST00000432587.2_Missense_Mutation_p.V824L|DCAF6_ENST00000367843.3_Missense_Mutation_p.V784L|DCAF6_ENST00000312263.6_Missense_Mutation_p.V764L	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	764					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						TAATCATGTGGTAAACTGCCT	0.418000													28	95					4.02929e-09	5.40493e-09	0.750413	1	0
MAPRE1	22919	broad.mit.edu	37	20	31436496	31436496	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:31436496G>A	ENST00000375571.5	+	7	908	c.769G>A	c.(769-771)Gat>Aat	p.D257N	RP5-1085F17.4_ENST00000565572.1_RNA	NM_012325.2	NP_036457.1	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family, member 1	257	DCTN1-binding.|Interaction with CDK5RAP2.|Interaction with MTUS2/TIP150.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8						TGTGATACCTGATGAAGGGGG	0.448000													37	34					0	0	0.853193	0	0
GPLD1	2822	broad.mit.edu	37	6	24466969	24466969	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:24466969T>C	ENST00000230036.1	-	10	870	c.760A>G	c.(760-762)Atg>Gtg	p.M254V	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	254						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CAAAATGCCATATCATCCAGT	0.383000													14	46					0	0	0.539581	0	0
AMOT	154796	broad.mit.edu	37	X	112033867	112033867	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:112033867C>G	ENST00000371959.3	-	7	2069	c.2070G>C	c.(2068-2070)gtG>gtC	p.V690V	AMOT_ENST00000371962.1_Silent_p.V458V|AMOT_ENST00000371958.1_Silent_p.V458V|AMOT_ENST00000304758.1_Silent_p.V281V|AMOT_ENST00000524145.1_Silent_p.V690V	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	690					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						AATGTCTCATCACATTCTCCT	0.493000													104	133					0	0	0.870114	0	0
COL24A1	255631	broad.mit.edu	37	1	86200574	86200574	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:86200574G>A	ENST00000370571.2	-	59	5222	c.4856C>T	c.(4855-4857)aCc>aTc	p.T1619I	COL24A1_ENST00000436319.1_Missense_Mutation_p.T1598I	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1619	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ACAGTGAATGGTGATGATATG	0.433000													16	98					0	0	0.557998	0	0
OR1B1	347169	broad.mit.edu	37	9	125391437	125391437	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:125391437C>A	ENST00000304833.3	-	1	415	c.378G>T	c.(376-378)gtG>gtT	p.V126V	RP11-64P14.7_ENST00000419604.1_RNA|RP11-64P14.7_ENST00000431442.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						CACAGATGGCCACATAGCGAT	0.507000													26	24					2.47511e-08	3.19489e-08	0.729181	1	0
OLFML2B	25903	broad.mit.edu	37	1	161953817	161953817	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161953817G>T	ENST00000294794.3	-	8	2324	c.1901C>A	c.(1900-1902)cCg>cAg	p.P634Q	OLFML2B_ENST00000367938.1_Missense_Mutation_p.P117Q|OLFML2B_ENST00000367940.2_Missense_Mutation_p.P635Q	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	634	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GTCCAGGGCCGGGTAGATGAG	0.627000													12	78					3.27435e-08	4.2035e-08	0.457914	1	0
CTSG	1511	broad.mit.edu	37	14	25042869	25042869	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:25042869G>T	ENST00000216336.2	-	5	778	c.742C>A	c.(742-744)Ctg>Atg	p.L248M		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	248					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		ATCTGATCCAGCAGTTTGAAG	0.517000													67	171					2.10938e-32	4.32446e-32	0.870114	1	0
RUNX3	864	broad.mit.edu	37	1	25245810	25245810	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:25245810A>T	ENST00000399916.1	-	4	945	c.507T>A	c.(505-507)acT>acA	p.T169T	RUNX3_ENST00000338888.3_Silent_p.T169T|RUNX3_ENST00000540420.1_Silent_p.T62T|RUNX3_ENST00000308873.6_Silent_p.T155T|RUNX3_ENST00000496967.1_5'UTR	NM_001031680.2	NP_001026850.1	Q13761	RUNX3_HUMAN	runt-related transcription factor 3	155	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(3)	18		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		TGGTGAACACAGTGATGGTCA	0.612000													33	58					0	0	0.834066	0	0
NRXN2	9379	broad.mit.edu	37	11	64435962	64435962	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:64435962G>T	ENST00000265459.6	-	8	1773	c.1312C>A	c.(1312-1314)Ctg>Atg	p.L438M	NRXN2_ENST00000409571.1_Missense_Mutation_p.L431M|NRXN2_ENST00000377559.3_Missense_Mutation_p.L407M|NRXN2_ENST00000377551.1_Missense_Mutation_p.L438M	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	438	Laminin G-like 2.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						GAGCCCGGCAGGTCAGCTGTG	0.607000													24	80					2.44723e-14	3.85091e-14	0.681144	1	0
NLRP3	114548	broad.mit.edu	37	1	247582310	247582310	+	Missense_Mutation	SNP	G	G	T	rs117287351	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:247582310G>T	ENST00000366497.2	+	2	994	c.214G>T	c.(214-216)Gtg>Ttg	p.V72L	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Missense_Mutation_p.V72L|NLRP3_ENST00000391827.2_Missense_Mutation_p.V72L|NLRP3_ENST00000348069.2_Missense_Mutation_p.V72L|NLRP3_ENST00000366496.2_Missense_Mutation_p.V72L|NLRP3_ENST00000336119.3_Missense_Mutation_p.V72L	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	72	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GGCCATGGCCGTGTGGATCTT	0.512000													7	65					0.00448238	0.0047419	0.307466	1	0
TAS2R39	259285	broad.mit.edu	37	7	142880808	142880808	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142880808C>A	ENST00000446620.1	+	1	297	c.297C>A	c.(295-297)acC>acA	p.T99T		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	99					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TCAGCTCAACCTCCCTAAGTT	0.388000													37	68					6.2361e-21	1.13835e-20	0.834066	1	0
ADCY8	114	broad.mit.edu	37	8	131922043	131922043	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:131922043G>A	ENST00000286355.5	-	6	3643	c.1551C>T	c.(1549-1551)tgC>tgT	p.C517C	ADCY8_ENST00000377928.3_Silent_p.C517C	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	517					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCAAAACACCGCACAGCACCG	0.473000										HNSCC(32;0.087)			51	120					0	0	0.870114	0	0
COQ4	51117	broad.mit.edu	37	9	131087421	131087421	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:131087421G>T	ENST00000300452.3	+	3	525		c.e3-1		COQ4_ENST00000372875.3_Splice_Site	NM_016035.3	NP_057119.2	Q9Y3A0	COQ4_HUMAN	coenzyme Q4						ubiquinone biosynthetic process	mitochondrial inner membrane				endometrium(4)|large_intestine(1)|lung(4)	9						TGTCCTTTCAGACATGGTCGC	0.527000													18	30					1.36565e-18	2.37537e-18	0.639603	1	0
XYLT1	64131	broad.mit.edu	37	16	17353050	17353050	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:17353050C>A	ENST00000261381.6	-	3	792	c.708G>T	c.(706-708)ccG>ccT	p.P236P		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	236					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGGCATGAGGCGGTCTGGACA	0.622000													29	239					4.74835e-14	7.4161e-14	0.750413	1	0
TNFSF4	7292	broad.mit.edu	37	1	173155712	173155712	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:173155712C>T	ENST00000281834.3	-	3	631	c.495G>A	c.(493-495)gtG>gtA	p.V165V	TNFSF4_ENST00000367718.1_Silent_p.V115V	NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	165					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						CTCCGCCATTCACATGGAAGT	0.458000													31	98					0	0	0.847076	0	0
EVX1	2128	broad.mit.edu	37	7	27285905	27285905	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:27285905C>A	ENST00000496902.4	+	3	1571	c.1085C>A	c.(1084-1086)cCc>cAc	p.P362H	EVX1_ENST00000222761.3_3'UTR|EVX1-AS_ENST00000517726.1_RNA|EVX1_ENST00000535619.1_Missense_Mutation_p.P180H			P49640	EVX1_HUMAN	even-skipped homeobox 1	362	Ala-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|liver(1)|lung(10)|prostate(1)|skin(1)	14						GGGCTGGCGCCCCGGGCTGCC	0.761000													5	20					3.59834e-05	4.08202e-05	0.217242	1	0
NR4A1	3164	broad.mit.edu	37	12	52448224	52448224	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:52448224G>T	ENST00000545748.1	+	3	1269	c.274G>T	c.(274-276)Gcc>Tcc	p.A92S	NR4A1_ENST00000243050.1_Missense_Mutation_p.A38S|NR4A1_ENST00000394825.1_Missense_Mutation_p.A38S|NR4A1_ENST00000547206.1_3'UTR|NR4A1_ENST00000550082.1_Missense_Mutation_p.A51S|NR4A1_ENST00000548232.1_Missense_Mutation_p.A38S|NR4A1_ENST00000360284.3_Missense_Mutation_p.A51S|NR4A1_ENST00000394824.2_Missense_Mutation_p.A38S			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	38	Poly-Ser.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CATGGACCTGGCCAGCCCCGA	0.647000													27	33					7.65355e-07	9.31694e-07	0.760397	1	0
ZNF653	115950	broad.mit.edu	37	19	11598536	11598536	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:11598536C>T	ENST00000293771.5	-	4	878	c.742G>A	c.(742-744)Gtc>Atc	p.V248I	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						ACGTGGTGGACGTCAAAGGGA	0.687000													4	95					0	0	0.184627	0	0
KIF3B	9371	broad.mit.edu	37	20	30915464	30915464	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:30915464G>T	ENST00000375712.3	+	7	2135	c.1968_splice	c.e7+1	p.R656_splice	KIF3B_ENST00000418717.2_Splice_Site_p.R282_splice	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	656	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCCGATATAGGGTGAGAAGAT	0.468000													12	39					7.93312e-07	9.63234e-07	0.457914	1	0
AACS	65985	broad.mit.edu	37	12	125612799	125612799	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:125612799G>T	ENST00000316519.6	+	13	1608	c.1402G>T	c.(1402-1404)Gtg>Ttg	p.V468L	AACS_ENST00000316543.10_Missense_Mutation_p.V66L|AACS_ENST00000261686.6_Missense_Mutation_p.V468L|AACS_ENST00000545511.1_Silent_p.P47P	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	468					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GGGCATGGCCGTGGAAGCGTG	0.537000													5	52					0.00198382	0.00212133	0.248553	1	0
TUBB1	81027	broad.mit.edu	37	20	57599101	57599101	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:57599101C>A	ENST00000217133.1	+	4	888	c.619C>A	c.(619-621)Ctc>Atc	p.L207I		NM_030773.3	NP_110400.1	Q9H4B7	TBB1_HUMAN	tubulin, beta 1 class VI	207					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	CAATGAGGCCCTCTATGACAT	0.537000													59	101					9.65139e-37	2.0386e-36	0.870114	1	0
SIGLEC7	27036	broad.mit.edu	37	19	51645885	51645885	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:51645885G>T	ENST00000317643.6	+	1	328	c.259G>T	c.(259-261)Gtg>Ttg	p.V87L	SIGLEC7_ENST00000305628.7_Missense_Mutation_p.V87L|SIGLEC7_ENST00000600577.1_Missense_Mutation_p.V87L	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	87	Ig-like V-type.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		AGCTTGGGCAGTGCAGGAGGA	0.562000													50	58					2.47907e-22	4.62857e-22	0.870114	1	0
RPA4	29935	broad.mit.edu	37	X	96139982	96139982	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:96139982G>T	ENST00000373040.3	+	1	1076	c.673G>T	c.(673-675)Gct>Tct	p.A225S	DIAPH2_ENST00000373061.3_Intron|DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000324765.8_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000355827.4_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	225					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						TGAGCTCCGGGCTCAGCTCTG	0.512000								Other identified genes with known or suspected DNA repair function					9	53					5.68852e-11	8.12276e-11	0.307466	1	0
LUZP4	51213	broad.mit.edu	37	X	114540826	114540826	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:114540826G>T	ENST00000371920.3	+	4	406	c.399G>T	c.(397-399)gaG>gaT	p.E133D	LUZP4_ENST00000451986.2_Missense_Mutation_p.E51D	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	133						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GCCAGTCAGAGGGGAACCAGC	0.433000													8	39					0.0381472	0.0391243	0.278610	1	0
MCF2L2	23101	broad.mit.edu	37	3	183035952	183035952	+	Silent	SNP	C	C	A	rs137887401	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:183035952C>A	ENST00000328913.3	-	7	954	c.657G>T	c.(655-657)acG>acT	p.T219T	MCF2L2_ENST00000414362.2_Silent_p.T219T|MCF2L2_ENST00000473233.1_Silent_p.T219T|MCF2L2_ENST00000447025.2_Silent_p.T219T	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	219					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AGGACCCAAACGTCTGCAGCA	0.527000													44	56					1.51943e-15	2.46301e-15	0.870114	1	0
RABGAP1L	9910	broad.mit.edu	37	1	174219765	174219765	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:174219765C>A	ENST00000251507.4	+	6	1044	c.870C>A	c.(868-870)aaC>aaA	p.N290K	RABGAP1L_ENST00000367689.3_5'UTR|RABGAP1L_ENST00000357444.6_Missense_Mutation_p.N253K	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	290					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						GAAAAGGAAACTTTAGGTGAG	0.373000													10	71					7.03913e-09	9.3162e-09	0.411799	1	0
CNTNAP2	26047	broad.mit.edu	37	7	148112563	148112563	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:148112563G>T	ENST00000361727.3	+	24	4367	c.3851G>T	c.(3850-3852)cGg>cTg	p.R1284L	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Missense_Mutation_p.R343L	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1284					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTCCTGATCCGGTACATGTTC	0.582000										HNSCC(39;0.1)			18	55					4.26978e-12	6.33232e-12	0.654019	1	0
EPHA5	2044	broad.mit.edu	37	4	66467698	66467698	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:66467698G>T	ENST00000273854.3	-	3	1171	c.571C>A	c.(571-573)Cgt>Agt	p.R191S	EPHA5_ENST00000432638.2_Missense_Mutation_p.R191S|EPHA5_ENST00000354839.4_Missense_Mutation_p.R191S|EPHA5_ENST00000511294.1_Missense_Mutation_p.R191S	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	191					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TTCATAACACGGTCACCAAGA	0.398000										TSP Lung(17;0.13)			18	54					3.99206e-14	6.25046e-14	0.557998	1	0
RBP3	5949	broad.mit.edu	37	10	48388049	48388049	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:48388049C>A	ENST00000224600.4	-	1	2942	c.2829G>T	c.(2827-2829)acG>acT	p.T943T		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	943	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GCTTCCCGGCCGTCTGCAGCA	0.627000													26	33					1.06801e-11	1.56298e-11	0.740014	1	0
CCDC81	60494	broad.mit.edu	37	11	86086208	86086208	+	Translation_Start_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:86086208G>T	ENST00000445632.2	+	1	275	c.3G>T	c.(1-3)atG>atT	p.M1I	CCDC81_ENST00000354755.1_Start_Codon_SNP_p.M1I|CCDC81_ENST00000278487.3_5'UTR	NM_001156474.1	NP_001149946.1	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	1										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				AATTGGAGATGTTGGATACGA	0.552000													46	158					3.40343e-31	6.93209e-31	0.870114	1	0
SLC4A11	83959	broad.mit.edu	37	20	3211997	3211997	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:3211997G>T	ENST00000380059.3	-	8	1157	c.1056C>A	c.(1054-1056)ctC>ctA	p.L352L	SLC4A11_ENST00000380056.3_Silent_p.L325L|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Silent_p.L309L	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	325					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						TGTGGGCAGGGAGGGAGACTG	0.662000													19	33					3.62473e-10	5.01968e-10	0.608945	1	0
TBX20	57057	broad.mit.edu	37	7	35242294	35242294	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:35242294G>T	ENST00000408931.3	-	8	1618	c.1092C>A	c.(1090-1092)tcC>tcA	p.S364S		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	364						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GAGCAGTCAGGGACTGTGGGT	0.507000													14	15					6.72482e-11	9.57346e-11	0.479597	1	0
GPLD1	2822	broad.mit.edu	37	6	24473860	24473860	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:24473860C>T	ENST00000230036.1	-	6	587	c.477G>A	c.(475-477)tcG>tcA	p.S159S	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	159						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						AATCACCAGCCGAATGAGCCT	0.368000													11	31					0	0	0.500413	0	0
LRIT1	26103	broad.mit.edu	37	10	85992382	85992382	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:85992382G>T	ENST00000372105.3	-	4	1194	c.1173C>A	c.(1171-1173)gtC>gtA	p.V391V		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	391						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						CAGTGGCCAGGACAGCGGGTT	0.617000													6	11					0.0215528	0.0222625	0.217242	1	0
OBSCN	84033	broad.mit.edu	37	1	228509541	228509541	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:228509541G>T	ENST00000570156.2	+	66	17944	c.17870G>T	c.(17869-17871)gGg>gTg	p.G5957V	OBSCN_ENST00000366709.4_Missense_Mutation_p.G2119V|OBSCN_ENST00000366707.4_Missense_Mutation_p.G2634V|OBSCN_ENST00000422127.1_Missense_Mutation_p.G5000V|OBSCN_ENST00000284548.11_Missense_Mutation_p.G5000V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5000	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGCTCCTCTGGGGGTGAGCTG	0.617000													20	109					9.86323e-18	1.68139e-17	0.667858	1	0
RIMS2	9699	broad.mit.edu	37	8	104922615	104922615	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:104922615C>A	ENST00000262231.10	+	3	1363	c.1115C>A	c.(1114-1116)tCt>tAt	p.S372Y	RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000436393.2_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	595					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AACACCAGGTCTGAGAGACAA	0.418000										HNSCC(12;0.0054)			28	118					4.11147e-13	6.26035e-13	0.788014	1	0
BOLL	66037	broad.mit.edu	37	2	198631311	198631311	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:198631311C>A	ENST00000321801.7	-	7	1103	c.533G>T	c.(532-534)aGc>aTc	p.S178I	AC011997.1_ENST00000409845.1_Intron|BOLL_ENST00000433157.1_Missense_Mutation_p.S166I|BOLL_ENST00000430004.1_Missense_Mutation_p.S166I|BOLL_ENST00000282278.8_Missense_Mutation_p.S57I|BOLL_ENST00000392296.4_Missense_Mutation_p.S166I	NM_197970.2	NP_932074.1	Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	166	DAZ-like.				cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						CACAGGGGAGCTACATACAGA	0.343000													4	19					1.024e-07	1.29427e-07	0.184627	1	0
COL6A6	131873	broad.mit.edu	37	3	130284032	130284032	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:130284032G>T	ENST00000358511.6	+	3	887	c.856G>T	c.(856-858)Ggc>Tgc	p.G286C	COL6A6_ENST00000453409.2_Missense_Mutation_p.G286C	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	286	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ACTGAGCATGGGCATAAATAA	0.448000													6	71					2.0095e-06	2.40577e-06	0.248553	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576397	33576397	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:33576397G>C	ENST00000504830.1	-	19	4069	c.3734C>G	c.(3733-3735)gCc>gGc	p.A1245G	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.A1160G	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1245	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAGAGTGTTGGCTGGCTTTTC	0.537000										HNSCC(64;0.19)			8	93					0	0	0.335167	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364552	142364552	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142364552C>A	ENST00000390397.2	+	0	223																											ACTGGGCCTACGGTTGATCTA	0.438000													11	37					6.31663e-08	8.01611e-08	0.479597	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103006602	103006602	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:103006602A>T	ENST00000375735.2	+	17	2643	c.2499A>T	c.(2497-2499)gcA>gcT	p.A833A	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Silent_p.A833A	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	833	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ATAGAAATGCAAGTGGATTTT	0.358000													8	28					0	0	0.307466	0	0
LRP6	4040	broad.mit.edu	37	12	12274345	12274345	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:12274345T>C	ENST00000261349.4	-	23	4633	c.4557A>G	c.(4555-4557)ccA>ccG	p.P1519P	BCL2L14_ENST00000396369.1_Intron|LRP6_ENST00000543091.1_Silent_p.P1474P	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1519					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GGTAGCTATATGGCCTGTAGC	0.453000													51	57					0	0	0.870114	0	0
PDE10A	10846	broad.mit.edu	37	6	165808689	165808689	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:165808689G>T	ENST00000366882.1	-	16	1610	c.1456C>A	c.(1456-1458)Cgg>Agg	p.R486R	PDE10A_ENST00000539869.2_Silent_p.R496R|PDE10A_ENST00000354448.4_Silent_p.R486R			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	486					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCACAGGACCGATGAACCATG	0.383000													17	10					1.01871e-10	1.44586e-10	0.575678	1	0
IRAK3	11213	broad.mit.edu	37	12	66597548	66597548	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:66597548A>T	ENST00000261233.4	+	2	612	c.191A>T	c.(190-192)cAa>cTa	p.Q64L	IRAK3_ENST00000457197.2_Intron	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	64	Death.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		TATGTAGACCAAGGTAAAAGT	0.418000													20	31					0	0	0.639603	0	0
NOTCH1	4851	broad.mit.edu	37	9	139396781	139396781	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:139396781G>C	ENST00000277541.6	-	28	5402	c.5327C>G	c.(5326-5328)tCt>tGt	p.S1776C		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1776					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCTGGCCTCAGACACTTTGAA	0.677000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			8	51					0	0	0.411799	0	0
HOXA3	3200	broad.mit.edu	37	7	27148329	27148329	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:27148329G>T	ENST00000396352.4	-	3	736	c.537C>A	c.(535-537)tgC>tgA	p.C179*	HOXA3_ENST00000317201.2_Nonsense_Mutation_p.C179*|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	179					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						TGTCGCCAGCGCAGCTTTCGC	0.711000													11	20					1.08611e-07	1.36452e-07	0.387290	1	0
SLC25A2	83884	broad.mit.edu	37	5	140682577	140682577	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140682577C>A	ENST00000239451.4	-	1	1035	c.856G>T	c.(856-858)Gcc>Tcc	p.A286S		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	286					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TATTCGTAGGCCACAAACAGT	0.443000													9	15					6.40141e-05	7.20973e-05	0.387290	1	0
KLHL11	55175	broad.mit.edu	37	17	40011242	40011242	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:40011242T>A	ENST00000319121.3	-	2	937	c.877A>T	c.(877-879)Agg>Tgg	p.R293W		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	293	BACK.					extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				TGGGACAACCTGAGCAATTTA	0.418000													13	19					0	0	0.435327	0	0
MPZL1	9019	broad.mit.edu	37	1	167741713	167741713	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:167741713G>T	ENST00000359523.2	+	3	662	c.460G>T	c.(460-462)Gtc>Ttc	p.V154F	MPZL1_ENST00000474859.1_Missense_Mutation_p.V154F|MPZL1_ENST00000392121.3_Intron	NM_003953.5|NM_024569.4	NP_003944.1|NP_078845.3	O95297	MPZL1_HUMAN	myelin protein zero-like 1	154					cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(2)	15	all_hematologic(923;0.215)					TAGGCTCTATGTCGTAGAAAA	0.398000													21	102					6.32553e-13	9.56965e-13	0.681144	1	0
OR5L1	219437	broad.mit.edu	37	11	55579067	55579067	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55579067A>T	ENST00000333973.2	+	1	214	c.125A>T	c.(124-126)aAc>aTc	p.N42I		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TTGTTAGCCAACCTGGGCATG	0.502000													86	224					0	0	0.870114	0	0
PRR23C	389152	broad.mit.edu	37	3	138762888	138762888	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:138762888C>T	ENST00000413199.1	-	1	846	c.575G>A	c.(574-576)gGc>gAc	p.G192D	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.G192D	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	192	Pro-rich.									breast(2)|lung(7)|skin(2)	11						TCGGATGGGGCCCTCCCGGTA	0.647000													6	36					0	0	0.307466	0	0
GABPA	2551	broad.mit.edu	37	21	27141346	27141346	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:27141346G>T	ENST00000354828.3	+	10	1695	c.1168G>T	c.(1168-1170)Gtt>Ttt	p.V390F	GABPA_ENST00000400075.3_Missense_Mutation_p.V390F	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	390					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						GATTTGTAAAGTTCAAGGCAA	0.343000													16	125					0.00047179	0.000516526	0.654019	1	0
EFHB	151651	broad.mit.edu	37	3	19961394	19961394	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:19961394G>T	ENST00000295824.9	-	3	1088	c.927C>A	c.(925-927)taC>taA	p.Y309*	EFHB_ENST00000498089.1_5'UTR|EFHB_ENST00000344838.4_Nonsense_Mutation_p.Y179*	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	309					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TTGCTCTTCCGTAAAATACTC	0.348000													25	54					1.99505e-19	3.53882e-19	0.760397	1	0
FCN1	2219	broad.mit.edu	37	9	137804989	137804989	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:137804989C>A	ENST00000371806.3	-	6	432	c.340_splice	c.e6-1	p.G114_splice		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	114	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GTTGCGTGGGCCTGGGAAGGG	0.682000													11	22					4.68919e-08	5.99121e-08	0.361761	1	0
DOCK10	55619	broad.mit.edu	37	2	225729642	225729642	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:225729642G>T	ENST00000409592.3	-	12	1515	c.1402C>A	c.(1402-1404)Caa>Aaa	p.Q468K	DOCK10_ENST00000258390.7_Missense_Mutation_p.Q474K			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	474							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCTTCTGATTGTCTTGGAGTG	0.443000													5	134					5.9392e-07	7.24875e-07	0.217242	1	0
REEP4	80346	broad.mit.edu	37	8	21996234	21996234	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:21996234C>A	ENST00000306306.3	-	7	1094	c.626G>T	c.(625-627)cGg>cTg	p.R209L	REEP4_ENST00000523293.1_Intron|REEP4_ENST00000334530.5_Missense_Mutation_p.G164W	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	209						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		GGCTGGCGCCCGGGGGACTGC	0.662000													50	47					1.08241e-25	2.09362e-25	0.870114	1	0
SFSWAP	6433	broad.mit.edu	37	12	132204076	132204076	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:132204076G>T	ENST00000261674.4	+	4	739	c.598G>T	c.(598-600)Gtg>Ttg	p.V200L	SFSWAP_ENST00000541286.1_Missense_Mutation_p.V200L	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	200					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						CCCGTCTGACGTGGAGTTGGT	0.398000													9	21					9.31168e-06	1.08377e-05	0.435327	1	0
FTH1P3	2498	broad.mit.edu	37	5	17354348	17354348	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:17354348C>A	ENST00000511821.1	+	0	207				FTH1P10_ENST00000401830.3_RNA																							GTTCCCTCTCCTCATGAGATT	0.473000													37	34					4.32679e-17	7.27705e-17	0.827153	1	0
ZFP37	7539	broad.mit.edu	37	9	115805325	115805325	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:115805325C>G	ENST00000374227.3	-	4	1600	c.1573G>C	c.(1573-1575)Ggc>Cgc	p.G525R	ZFP37_ENST00000553380.1_Missense_Mutation_p.G540R|ZFP37_ENST00000555206.1_Missense_Mutation_p.G526R			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	525						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TGTTTAAAGCCTTTCCCACAT	0.393000													14	39					0	0	0.479597	0	0
CARD11	84433	broad.mit.edu	37	7	2968248	2968248	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:2968248C>A	ENST00000396946.4	-	13	2141	c.1738G>T	c.(1738-1740)Gac>Tac	p.D580Y		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	580					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TGGGGCGCGTCCTCCTTGTAG	0.657000			Mis		DLBCL								43	134					3.10996e-30	6.28673e-30	0.870114	1	0
ASCC3	10973	broad.mit.edu	37	6	101098455	101098455	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:101098455C>G	ENST00000369162.2	-	20	3555	c.3211G>C	c.(3211-3213)Gac>Cac	p.D1071H		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1071	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GAGAAACTGTCCATTTCTCCT	0.368000													9	40					0	0	0.387290	0	0
SHANK1	50944	broad.mit.edu	37	19	51165554	51165554	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:51165554G>C	ENST00000293441.1	-	23	6172	c.6154C>G	c.(6154-6156)Cca>Gca	p.P2052A	SHANK1_ENST00000359082.3_Missense_Mutation_p.P2043A|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391814.1_Missense_Mutation_p.P2060A|SHANK1_ENST00000391813.1_Missense_Mutation_p.P1439A	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2052					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACAAAGACTGGGGCGAAGGGG	0.701000													15	9					0	0	0.457914	0	0
HIF3A	64344	broad.mit.edu	37	19	46825057	46825057	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:46825057C>G	ENST00000339613.2	+	10	1256	c.1001C>G	c.(1000-1002)gCc>gGc	p.A334G	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000472815.1_Missense_Mutation_p.A321G|HIF3A_ENST00000244303.6_Missense_Mutation_p.A321G|HIF3A_ENST00000420102.2_Missense_Mutation_p.A339G|HIF3A_ENST00000377670.4_Missense_Mutation_p.A390G|HIF3A_ENST00000300862.3_Missense_Mutation_p.A388G|HIF3A_ENST00000600383.1_Missense_Mutation_p.A321G			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CGGATCCTTGCCTTCCTGCAC	0.682000													22	139					0	0	0.729181	0	0
RYR2	6262	broad.mit.edu	37	1	237961397	237961397	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237961397G>T	ENST00000366574.2	+	97	14334	c.14017G>T	c.(14017-14019)Gac>Tac	p.D4673Y	RYR2_ENST00000542537.1_Missense_Mutation_p.D4657Y|RYR2_ENST00000360064.6_Missense_Mutation_p.D4679Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4673					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTTGGCATGGACAAGGCAGC	0.438000													4	10					0.150653	0.152846	0.150653	1	0
CSPG4	1464	broad.mit.edu	37	15	75979993	75979993	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:75979993G>A	ENST00000308508.5	-	3	3505	c.3413C>T	c.(3412-3414)cCt>cTt	p.P1138L		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1138	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCCTCCTTGAGGGACCACAAG	0.662000													18	65					0	0	0.624587	0	0
GPR27	2850	broad.mit.edu	37	3	71804037	71804037	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:71804037G>T	ENST00000304411.2	+	1	837	c.837G>T	c.(835-837)gaG>gaT	p.E279D		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	279						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		TCAAGACGGAGAAGAGGCTGT	0.721000													16	23					1.40151e-16	2.32187e-16	0.592651	1	0
DZANK1	55184	broad.mit.edu	37	20	18440853	18440853	+	Translation_Start_Site	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:18440853T>C	ENST00000357236.4	-	0	415				DZANK1_ENST00000329494.5_Missense_Mutation_p.I69M|DZANK1_ENST00000262547.5_Missense_Mutation_p.I69M|DZANK1_ENST00000377630.5_De_novo_Start_OutOfFrame			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1							intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						TAATAGGTTTTATATACTTAA	0.308000													5	27					0	0	0.184627	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564182	33564182	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:33564182C>T	ENST00000321505.4	+	1	362	c.182C>T	c.(181-183)cCc>cTc	p.P61L	KIAA1549L_ENST00000389726.3_Missense_Mutation_p.P61L|KIAA1549L_ENST00000265654.5_Missense_Mutation_p.P61L					KIAA1549-like																		TCTCCCCCTCCCCCAGCACTT	0.562000													22	61					0	0	0.667858	0	0
AFF2	2334	broad.mit.edu	37	X	148035270	148035270	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:148035270G>T	ENST00000370460.2	+	10	2036		c.e10+1		AFF2_ENST00000342251.3_Splice_Site|AFF2_ENST00000370457.5_Splice_Site|AFF2_ENST00000286437.5_Splice_Site	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2						brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AACTCCAGAGGTGAGTGAAGG	0.547000													15	120					3.32936e-07	4.09265e-07	0.539581	1	0
SCN10A	6336	broad.mit.edu	37	3	38797433	38797433	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:38797433C>T	ENST00000449082.2	-	10	1306	c.1307G>A	c.(1306-1308)gGg>gAg	p.G436E		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	436					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGTGTCAATCCCTAGTGCTGC	0.502000													36	44					0	0	0.812448	0	0
BTBD9	114781	broad.mit.edu	37	6	38561993	38561993	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:38561993C>A	ENST00000481247.1	-	3	447	c.296G>T	c.(295-297)cGg>cTg	p.R99L	BTBD9_ENST00000419706.2_Missense_Mutation_p.R40L|BTBD9_ENST00000403056.1_Missense_Mutation_p.R99L|BTBD9_ENST00000408958.1_Missense_Mutation_p.R31L|BTBD9_ENST00000314100.6_Missense_Mutation_p.R31L	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	99	BTB.				cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						CAGCGTTGCCCGCCCAGTGTA	0.473000													23	169					7.26314e-15	1.15061e-14	0.717897	1	0
IL15	3600	broad.mit.edu	37	4	142641718	142641718	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:142641718G>T	ENST00000296545.7	+	4	953	c.110_splice	c.e4+1	p.G37_splice	IL15_ENST00000529613.1_Splice_Site_p.G37_splice|IL15_ENST00000477265.1_5'UTR|IL15_ENST00000320650.4_Splice_Site_p.G37_splice|IL15_ENST00000514653.1_5'UTR			P40933	IL15_HUMAN	interleukin 15	37					cell-cell signaling|immune response|positive regulation of interleukin-17 production	endosome|extracellular space|Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	cytokine activity|cytokine receptor binding|signal transducer activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_hematologic(180;0.158)					CTTCATTTTGGGGTAATTTTA	0.323000													11	37					4.3838e-07	5.36431e-07	0.435327	1	0
TTC40	54777	broad.mit.edu	37	10	134660573	134660573	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:134660573C>A	ENST00000368586.5	-	43	6230	c.6130G>T	c.(6130-6132)Gag>Tag	p.E2044*	TTC40_ENST00000263170.5_Nonsense_Mutation_p.E205*	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	205										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						AGCAGCACCTCTGACGCCTGA	0.672000													12	26					0.000151284	0.000168372	0.435327	1	0
F13A1	2162	broad.mit.edu	37	6	6182293	6182293	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:6182293T>A	ENST00000264870.3	-	11	1652	c.1387A>T	c.(1387-1389)Aaa>Taa	p.K463*		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	463					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ACAATTAATTTCCCAATGTGG	0.398000													23	55					0	0	0.681144	0	0
DOCK2	1794	broad.mit.edu	37	5	169126459	169126459	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:169126459C>A	ENST00000256935.8	+	12	1209	c.1129C>A	c.(1129-1131)Caa>Aaa	p.Q377K		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	377					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGTGGAGGGCAAGGTAAAGT	0.507000													15	28					4.96729e-08	6.32934e-08	0.575678	1	0
DMXL1	1657	broad.mit.edu	37	5	118454634	118454634	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:118454634A>G	ENST00000311085.8	+	8	948	c.868A>G	c.(868-870)Att>Gtt	p.I290V	DMXL1_ENST00000539542.1_Missense_Mutation_p.I290V	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	290										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GACTGAATCAATTAATTTAAC	0.348000													16	22					0	0	0.575678	0	0
LILRA3	11026	broad.mit.edu	37	19	54802639	54802639	+	Missense_Mutation	SNP	G	G	T	rs143103718	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:54802639G>T	ENST00000391745.1	-	9	1169	c.853C>A	c.(853-855)Cgc>Agc	p.R285S	LILRA3_ENST00000391744.3_Missense_Mutation_p.R204S|LILRA3_ENST00000251390.3_Missense_Mutation_p.R268S					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGGCCAGGGCGCTGGAGGAAG	0.642000													41	117					1.61863e-15	2.61931e-15	0.870114	1	0
IRS4	8471	broad.mit.edu	37	X	107977487	107977487	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:107977487C>A	ENST00000372129.2	-	1	2164	c.2088G>T	c.(2086-2088)gaG>gaT	p.E696D		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	696	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						ATGGGTCATCCTCATCTTCAT	0.498000													27	233					2.4375e-19	4.29932e-19	0.717897	1	0
DKC1	1736	broad.mit.edu	37	X	154001506	154001506	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:154001506G>T	ENST00000369550.5	+	11	1347	c.1137G>T	c.(1135-1137)aaG>aaT	p.K379N	DKC1_ENST00000475966.1_3'UTR	NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	379					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACCCTCGGAAGTGGGGTTTAG	0.398000									Congenital Dyskeratosis				11	85					2.62699e-14	4.12687e-14	0.479597	1	0
ZNF613	79898	broad.mit.edu	37	19	52448661	52448661	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:52448661G>T	ENST00000293471.6	+	6	2204	c.1525G>T	c.(1525-1527)Gag>Tag	p.E509*	ZNF613_ENST00000601794.1_3'UTR|ZNF613_ENST00000391794.4_Nonsense_Mutation_p.E473*	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		TCATACAGGGGAGAGACCGTA	0.448000													29	18					3.90053e-15	6.24217e-15	0.760397	1	0
KIAA2022	340533	broad.mit.edu	37	X	73963690	73963690	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:73963690G>A	ENST00000373468.1	-	3	1353	c.702C>T	c.(700-702)agC>agT	p.S234S	KIAA2022_ENST00000055682.5_Silent_p.S234S			Q5QGS0	K2022_HUMAN	KIAA2022	234					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CCTCATAATAGCTTTTCTGAG	0.448000													27	92					0	0	0.769981	0	0
TRIO	7204	broad.mit.edu	37	5	14358360	14358360	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:14358360A>T	ENST00000344204.4	+	12	2144	c.2120A>T	c.(2119-2121)cAg>cTg	p.Q707L	TRIO_ENST00000509967.2_Missense_Mutation_p.Q658L|TRIO_ENST00000537187.1_Missense_Mutation_p.Q707L	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	707					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GAGGCCGTGCAGGACCTCATC	0.637000													18	199					0	0	0.608945	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885887	88885887	+	Silent	SNP	G	G	T	rs117836552	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:88885887G>T	ENST00000319675.3	-	1	409	c.313C>A	c.(313-315)Cga>Aga	p.R105R		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	105										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GTCAGGCCTCGCATGGTGATG	0.537000													30	129					6.29468e-14	9.81491e-14	0.804634	1	0
CSE1L	1434	broad.mit.edu	37	20	47688901	47688901	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:47688901G>T	ENST00000262982.2	+	9	970	c.847G>T	c.(847-849)Gat>Tat	p.D283Y	CSE1L_ENST00000396192.3_Intron|CSE1L_ENST00000542325.1_Missense_Mutation_p.D66Y	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	283					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ACAAAAGTACGATGAAGAATT	0.393000													14	92					2.23348e-06	2.67223e-06	0.500413	1	0
MYO3A	53904	broad.mit.edu	37	10	26286130	26286130	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:26286130G>T	ENST00000265944.5	+	6	617	c.451G>T	c.(451-453)Gtg>Ttg	p.V151L	MYO3A_ENST00000376302.1_Missense_Mutation_p.V151L|MYO3A_ENST00000543632.1_Missense_Mutation_p.V151L|MYO3A_ENST00000376301.1_Missense_Mutation_p.V151L	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	151	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CCACAGAGATGTGAAAGGCAA	0.303000													18	71					6.21321e-17	1.04125e-16	0.639603	1	0
SMIM19	114926	broad.mit.edu	37	8	42407751	42407751	+	Nonstop_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:42407751A>G	ENST00000438528.3	+	4	373	c.324A>G	c.(322-324)tgA>tgG	p.*108W	SMIM19_ENST00000416469.2_Nonstop_Mutation_p.*108W|SMIM19_ENST00000417410.2_Nonstop_Mutation_p.*108W|SMIM19_ENST00000490331.2_Nonstop_Mutation_p.*108W|SMIM19_ENST00000414154.2_Nonstop_Mutation_p.*108W	NM_001135676.1	NP_001129148.1			small integral membrane protein 19																		CATTGGAATGAAACCTCAGAA	0.338000													28	52					0	0	0.819951	0	0
PCDH17	27253	broad.mit.edu	37	13	58299169	58299169	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:58299169C>A	ENST00000377918.3	+	4	3247	c.3221C>A	c.(3220-3222)aCt>aAt	p.T1074N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1074					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TACTTGCCCACTGACAGTCAA	0.532000													12	41					3.07112e-06	3.6397e-06	0.387290	1	0
GATA1	2623	broad.mit.edu	37	X	48650291	48650291	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:48650291C>A	ENST00000376670.3	+	3	372	c.261C>A	c.(259-261)atC>atA	p.I87I	GATA1_ENST00000376665.3_Silent_p.I87I	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	87					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V77_A120>A(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						TGGAGGGGATCCCAGGGGGCT	0.607000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								36	20					1.836e-18	3.18173e-18	0.788014	1	0
LY96	23643	broad.mit.edu	37	8	74941233	74941233	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:74941233G>T	ENST00000284818.2	+	5	518	c.427G>T	c.(427-429)Gaa>Taa	p.E143*	LY96_ENST00000518893.1_Nonsense_Mutation_p.E113*	NM_015364.4	NP_056179.3	Q9Y6Y9	LY96_HUMAN	lymphocyte antigen 96	143					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			TGGGAGCCCAGAAGAAATGCT	0.299000													8	65					2.68362e-12	4.01796e-12	0.411799	1	0
NRSN1	140767	broad.mit.edu	37	6	24134569	24134569	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:24134569G>T	ENST00000378491.4	+	3	315	c.14G>T	c.(13-15)aGc>aTc	p.S5I	NRSN1_ENST00000378475.1_Missense_Mutation_p.S5I|NRSN1_ENST00000378478.1_Missense_Mutation_p.S5I	NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	5					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						AGTTCTTGCAGCAACGTCTGT	0.517000													17	51					4.96729e-08	6.32934e-08	0.575678	1	0
SLC32A1	140679	broad.mit.edu	37	20	37356416	37356416	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:37356416G>T	ENST00000217420.1	+	2	975	c.712G>T	c.(712-714)Gtg>Ttg	p.V238L		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	238					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GGGGCTGCCCGTGTCGCAGAA	0.582000													24	47					6.32553e-13	9.56965e-13	0.681144	1	0
LAMB4	22798	broad.mit.edu	37	7	107698324	107698324	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:107698324C>A	ENST00000388781.3	-	24	3415	c.3332G>T	c.(3331-3333)aGt>aTt	p.S1111I	LAMB4_ENST00000388780.3_Missense_Mutation_p.S1111I|LAMB4_ENST00000205386.4_Missense_Mutation_p.S1111I	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1111	Laminin EGF-like 12.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGGCACTCACTGCAACGTTT	0.453000													12	39					3.07112e-06	3.6397e-06	0.387290	1	0
ARHGAP18	93663	broad.mit.edu	37	6	129905164	129905164	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:129905164C>A	ENST00000368149.2	-	13	1895	c.1807G>T	c.(1807-1809)Gat>Tat	p.D603Y	ARHGAP18_ENST00000463225.1_5'UTR	NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	603					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GCAAGTACATCACTGGCTTTT	0.473000													8	33					0.00448238	0.0047419	0.307466	1	0
ZNF676	163223	broad.mit.edu	37	19	22363186	22363186	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22363186C>T	ENST00000397121.2	-	3	1650	c.1333G>A	c.(1333-1335)Gga>Aga	p.G445R		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGTTTCTCTCCAGCATGAATT	0.428000													15	71					0	0	0.520397	0	0
HOXC12	3228	broad.mit.edu	37	12	54348973	54348973	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:54348973G>C	ENST00000243103.3	+	1	356	c.260G>C	c.(259-261)cGc>cCc	p.R87P		NM_173860.1	NP_776272.1	P31275	HXC12_HUMAN	homeobox C12	87					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	12						GAGCTGGCGCGCGTGGAGGAC	0.746000													3	24					0	0	0.184627	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599313	136599313	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:136599313G>T	ENST00000531224.1	-	4	958	c.706C>A	c.(706-708)Cct>Act	p.P236T	BCLAF1_ENST00000530767.1_Missense_Mutation_p.P236T|BCLAF1_ENST00000353331.4_Missense_Mutation_p.P234T|BCLAF1_ENST00000392348.2_Missense_Mutation_p.P234T|BCLAF1_ENST00000527759.1_Missense_Mutation_p.P234T|BCLAF1_ENST00000527536.1_Missense_Mutation_p.P236T	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	236					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTCTGACTAGGTGGTGTAGCA	0.443000													8	137					2.74318e-10	3.8242e-10	0.335167	1	0
SSTR1	6751	broad.mit.edu	37	14	38679753	38679753	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:38679753C>A	ENST00000267377.2	+	3	1776	c.1159C>A	c.(1159-1161)Cgg>Agg	p.R387R		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	387					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CTGCACGTCCCGGATCACGAC	0.657000													67	33					7.25294e-45	1.58537e-44	0.870114	1	0
GUCY2C	2984	broad.mit.edu	37	12	14774971	14774971	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:14774971C>G	ENST00000261170.3	-	22	2705	c.2569G>C	c.(2569-2571)Gac>Cac	p.D857H		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	857	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACAATGTGGTCAAAACTCTTA	0.403000													20	38					0	0	0.639603	0	0
PIGO	84720	broad.mit.edu	37	9	35093027	35093027	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:35093027C>A	ENST00000378617.3	-	6	1513	c.1119_splice	c.e6+1	p.Q373_splice	PIGO_ENST00000341666.3_Splice_Site_p.Q373_splice|PIGO_ENST00000361778.2_Splice_Site_p.Q373_splice|PIGO_ENST00000298004.5_Splice_Site_p.Q373_splice	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	373					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTTACCTACCTGCTGAGCAT	0.542000													25	50					9.78485e-24	1.86011e-23	0.769981	1	0
NRXN1	9378	broad.mit.edu	37	2	50724470	50724470	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:50724470C>A	ENST00000404971.1	-	15	4339		c.e15+1		NRXN1_ENST00000331040.5_Splice_Site|NRXN1_ENST00000402717.3_Splice_Site|NRXN1_ENST00000405472.3_Splice_Site|NRXN1_ENST00000401669.2_Splice_Site|NRXN1_ENST00000406316.2_Splice_Site|NRXN1_ENST00000406859.3_Splice_Site	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1						adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATGTACTCACCCTTTAACTA	0.333000													7	17					2.74318e-10	3.8242e-10	0.335167	1	0
LCP1	3936	broad.mit.edu	37	13	46721233	46721233	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:46721233C>A	ENST00000398576.2	-	13	1372	c.984G>T	c.(982-984)aaG>aaT	p.K328N	LCP1_ENST00000323076.2_Missense_Mutation_p.K328N			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	328	Actin-binding 1.|CH 2.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGATGTCATCCTTCTCCTGCA	0.522000			T	BCL6	NHL								8	14					0.0477658	0.0489092	0.307466	1	0
CFHR5	81494	broad.mit.edu	37	1	196977800	196977800	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:196977800C>G	ENST00000367414.5	+	10	1825	c.1769C>G	c.(1768-1770)cCt>cGt	p.P590R	CFHR5_ENST00000256785.4_Missense_Mutation_p.P566R	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	566					complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TTTGAATATCCTATATGTGAA	0.363000													22	56					0	0	0.693898	0	0
COL6A2	1292	broad.mit.edu	37	21	47537845	47537845	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:47537845G>T	ENST00000300527.4	+	12	1215	c.1111G>T	c.(1111-1113)Ggc>Tgc	p.G371C	COL6A2_ENST00000397763.1_Missense_Mutation_p.G371C|COL6A2_ENST00000409416.1_Missense_Mutation_p.G371C|COL6A2_ENST00000357838.4_Missense_Mutation_p.G371C|COL6A2_ENST00000310645.5_Missense_Mutation_p.G371C	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	371	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging	p.G371S(3)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGACCAAGGCGGCAAGGTAAG	0.687000													7	21					1.11149e-13	1.71884e-13	0.361761	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136925	40136925	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:40136925G>C	ENST00000278198.2	-	2	2881	c.918C>G	c.(916-918)aaC>aaG	p.N306K	LRRC4C_ENST00000528697.1_Missense_Mutation_p.N306K|LRRC4C_ENST00000530763.1_Missense_Mutation_p.N306K|LRRC4C_ENST00000527150.1_Missense_Mutation_p.N306K			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	306	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTATGTCACAGTTACAGTTCC	0.483000													39	97					0	0	0.870114	0	0
CYP2C18	1562	broad.mit.edu	37	10	96484144	96484144	+	Silent	SNP	C	C	A	rs140111676		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:96484144C>A	ENST00000285979.6	+	7	1202	c.1003C>A	c.(1003-1005)Cgg>Agg	p.R335R	CYP2C18_ENST00000339022.5_Silent_p.R276R|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18									p.R335W(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TGGCAGAAACCGGAGCCCCTG	0.488000													23	57					1.17739e-12	1.76985e-12	0.693898	1	0
VANGL2	57216	broad.mit.edu	37	1	160390876	160390876	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:160390876G>T	ENST00000368061.2	+	6	1446	c.972G>T	c.(970-972)cgG>cgT	p.R324R	VANGL2_ENST00000483408.1_3'UTR	NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	324					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCAGTCTCGGGCTGTGATTG	0.572000													14	77					1.45105e-14	2.29101e-14	0.539581	1	0
OR1I1	126370	broad.mit.edu	37	19	15198148	15198148	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:15198148C>T	ENST00000209540.2	+	1	358	c.272C>T	c.(271-273)gCc>gTc	p.A91V		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						CAGAGCAGAGCCATCCCCTTT	0.552000													45	18					0	0	0.870114	0	0
CYP7B1	9420	broad.mit.edu	37	8	65517323	65517323	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:65517323C>T	ENST00000310193.3	-	5	1322	c.1149G>A	c.(1147-1149)ggG>ggA	p.G383G	CYP7B1_ENST00000523954.1_5'UTR	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	383					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				CACAGTAGTCCCCGGTCTCTG	0.453000													8	43					0	0	0.335167	0	0
KCNC2	3747	broad.mit.edu	37	12	75444449	75444449	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:75444449G>T	ENST00000549446.1	-	3	2016	c.1336C>A	c.(1336-1338)Caa>Aaa	p.Q446K	KCNC2_ENST00000540018.1_Missense_Mutation_p.Q446K|KCNC2_ENST00000341669.3_Missense_Mutation_p.Q446K|KCNC2_ENST00000548513.1_Missense_Mutation_p.Q446K|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000550433.1_Missense_Mutation_p.Q446K|KCNC2_ENST00000393288.2_Missense_Mutation_p.Q446K|KCNC2_ENST00000350228.2_Missense_Mutation_p.Q446K|KCNC2_ENST00000298972.1_Missense_Mutation_p.Q446K	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	446					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GACCATGTTTGGGGGTACATA	0.507000													8	33					2.17888e-05	2.49279e-05	0.335167	1	0
EHMT1	79813	broad.mit.edu	37	9	140707596	140707596	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:140707596G>T	ENST00000460843.1	+	20	3033	c.3006G>T	c.(3004-3006)agG>agT	p.R1002S		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1002					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CCCCCGACAGGCCCAGCCCCG	0.627000													21	20					1.1804e-14	1.86524e-14	0.667858	1	0
SPEG	10290	broad.mit.edu	37	2	220309590	220309590	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:220309590G>A	ENST00000312358.7	+	3	654	c.522G>A	c.(520-522)ccG>ccA	p.P174P	SPEG_ENST00000396698.1_Silent_p.P70P|SPEG_ENST00000396695.2_5'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	174					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACACACCCCCGACCTCCGTGA	0.672000													17	85					0	0	0.592651	0	0
PLCB1	23236	broad.mit.edu	37	20	8705364	8705364	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:8705364A>G	ENST00000378641.3	+	16	2118	c.1643A>G	c.(1642-1644)cAg>cGg	p.Q548R	PLCB1_ENST00000338037.6_Missense_Mutation_p.Q548R|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.Q548R	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	548	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AACTATATTCAGCCAGTCAAG	0.368000													24	33					0	0	0.750413	0	0
SPRED2	200734	broad.mit.edu	37	2	65541010	65541010	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:65541010C>G	ENST00000356388.4	-	6	1071	c.882G>C	c.(880-882)cgG>cgC	p.R294R	SPRED2_ENST00000443619.2_Silent_p.R291R	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	294					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GCGACTTGCCCCGGGAGGGCT	0.662000													51	76					0	0	0.870114	0	0
SORCS3	22986	broad.mit.edu	37	10	106865211	106865211	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:106865211C>A	ENST00000369701.3	+	7	1377	c.1150C>A	c.(1150-1152)Cct>Act	p.P384T		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	384						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TAGAAGTGGGCCTTTTGCCCG	0.478000													20	49					5.26018e-13	7.99649e-13	0.608945	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577047	33577047	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:33577047C>A	ENST00000504830.1	-	19	3419	c.3084G>T	c.(3082-3084)agG>agT	p.R1028S	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.R943S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1028	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GCATTCTGGGCCTGGATGTAG	0.527000										HNSCC(64;0.19)			42	76					1.47197e-15	2.38814e-15	0.834066	1	0
SPATA17	128153	broad.mit.edu	37	1	217955516	217955516	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:217955516G>T	ENST00000366933.4	+	8	779	c.723_splice	c.e8-1	p.G242_splice	RP11-415L24.1_ENST00000415765.1_RNA	NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	242						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		GTCTTGTCAGGGGCCCTTCCG	0.438000													13	63					1.15088e-07	1.44013e-07	0.500413	1	0
DNASE1L3	1776	broad.mit.edu	37	3	58196594	58196594	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:58196594A>G	ENST00000483681.1	-	3	621	c.40T>C	c.(40-42)Tcc>Ccc	p.S14P	DNASE1L3_ENST00000394549.2_Missense_Mutation_p.S14P|DNASE1L3_ENST00000318316.3_Missense_Mutation_p.S14P|DNASE1L3_ENST00000486455.1_Missense_Mutation_p.S14P			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	14					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		CTGTGGATGGAGAGGAGGAGA	0.557000													8	33					0	0	0.278610	0	0
ATRNL1	26033	broad.mit.edu	37	10	117704247	117704247	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:117704247G>A	ENST00000355044.3	+	29	4223	c.4097G>A	c.(4096-4098)cGg>cAg	p.R1366Q	ATRNL1_ENST00000423111.2_Missense_Mutation_p.R417Q|ATRNL1_ENST00000303745.7_Missense_Mutation_p.R159Q	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1366						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCTGGAGTCCGGAATCGAAAA	0.413000													12	38					0	0	0.435327	0	0
GRID1	2894	broad.mit.edu	37	10	87966388	87966388	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:87966388G>T	ENST00000327946.7	-	3	338	c.253C>A	c.(253-255)Cag>Aag	p.Q85K		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	85						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AAAATCCCCTGGGTCATGAGG	0.592000										Multiple Myeloma(13;0.14)			9	17					0.00829132	0.00869318	0.361761	1	0
WBSCR17	64409	broad.mit.edu	37	7	70853323	70853323	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:70853323C>A	ENST00000333538.5	+	3	1159	c.525C>A	c.(523-525)gcC>gcA	p.A175A	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	175	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.A175A(1)		NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGCACAGTGCCGTCAATCACA	0.547000													33	75					6.29468e-14	9.81491e-14	0.804634	1	0
HECW2	57520	broad.mit.edu	37	2	197184400	197184400	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:197184400C>A	ENST00000260983.2	-	9	1396	c.1214G>T	c.(1213-1215)aGg>aTg	p.R405M	HECW2_ENST00000409111.1_Missense_Mutation_p.R49M	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	405					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AGGTGAGGTCCTTGAAGACGT	0.517000													39	27					3.7052e-28	7.37904e-28	0.864702	1	0
DNAH9	1770	broad.mit.edu	37	17	11659961	11659961	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:11659961G>C	ENST00000262442.3	+	34	6883	c.6815G>C	c.(6814-6816)cGc>cCc	p.R2272P	DNAH9_ENST00000454412.2_Missense_Mutation_p.R2272P	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2272	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGCCACCTGCGCACAGCCACT	0.547000													39	137					0	0	0.870114	0	0
DGKK	139189	broad.mit.edu	37	X	50213230	50213230	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:50213230C>A	ENST00000376025.2	-	0	507							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					ggctctggggccagctctggg	0.637000													13	15					0.0202918	0.0210061	0.457914	1	0
KDELC1	79070	broad.mit.edu	37	13	103443473	103443473	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:103443473C>A	ENST00000376004.4	-	6	1197	c.861G>T	c.(859-861)atG>atT	p.M287I	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	287						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GCACGGACATCATATCCAGAC	0.468000													13	141					1.5842e-08	2.06902e-08	0.435327	1	0
PDGFC	56034	broad.mit.edu	37	4	157693838	157693838	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:157693838C>A	ENST00000502773.1	-	4	1193	c.703_splice	c.e4+1	p.V235_splice	PDGFC_ENST00000422544.2_Splice_Site_p.V235_splice|PDGFC_ENST00000504672.1_5'UTR|PDGFC_ENST00000541126.1_Splice_Site_p.V72_splice|PDGFC_ENST00000542208.1_Splice_Site_p.V80_splice	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	235		Cleavage (Potential).			central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		GGGAGCTTACCTCTGGATTTT	0.378000													5	21					0.00198382	0.00212133	0.248553	1	0
MAX	4149	broad.mit.edu	37	14	65560456	65560456	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:65560456C>A	ENST00000284165.6	-	3	289	c.141G>T	c.(139-141)cgG>cgT	p.R47R	MAX_ENST00000341653.2_Silent_p.R47R|MAX_ENST00000557746.1_Silent_p.R38R|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000556979.1_Silent_p.R47R|MAX_ENST00000556443.1_Silent_p.R38R|RP11-840I19.3_ENST00000555261.1_RNA|RP11-840I19.3_ENST00000555898.1_RNA|MAX_ENST00000555932.1_Intron|MAX_ENST00000555667.1_Silent_p.R38R|MAX_ENST00000555419.1_Intron|MAX_ENST00000358402.4_Silent_p.R38R|RP11-840I19.3_ENST00000553633.1_RNA|MAX_ENST00000358664.4_Silent_p.R47R|MAX_ENST00000246163.2_Silent_p.R47R	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	47	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GGACTGAGTCCCGCAAACTGT	0.488000													21	73					2.08973e-25	4.03785e-25	0.693898	1	0
OR11H6	122748	broad.mit.edu	37	14	20692601	20692601	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:20692601T>A	ENST00000315519.2	+	1	811	c.733T>A	c.(733-735)Tgt>Agt	p.C245S		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		AGCTGTGCTTTGTATTCCCTC	0.463000													9	36					0	0	0.361761	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455636	5455636	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:5455636C>A	ENST00000222033.4	+	1	211	c.134C>A	c.(133-135)cCc>cAc	p.P45H		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	45						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CCTGGGAGACCCCGGAGATGC	0.687000													33	17					1.42033e-22	2.66507e-22	0.796494	1	0
TEAD4	7004	broad.mit.edu	37	12	3149426	3149426	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:3149426G>T	ENST00000359864.2	+	12	1381		c.e12+1		TEAD4_ENST00000358409.2_Splice_Site|TEAD4_ENST00000397122.2_Splice_Site	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4						hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CATCCTGCAGGTGTGCGGCGG	0.557000													35	58					2.95478e-19	5.20196e-19	0.840704	1	0
C5orf49	134121	broad.mit.edu	37	5	7835549	7835549	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:7835549C>A	ENST00000399810.2	-	2	678	c.210G>T	c.(208-210)ttG>ttT	p.L70F	C5orf49_ENST00000509627.1_Missense_Mutation_p.L70F	NM_001089584.2	NP_001083053.1	A4QMS7	CE049_HUMAN	chromosome 5 open reading frame 49	70										large_intestine(3)|lung(5)|skin(1)	9						CATCTCGGTGCAACTTCTGAT	0.348000													46	95					1.48341e-19	2.64623e-19	0.870114	1	0
XIRP2	129446	broad.mit.edu	37	2	168107597	168107597	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:168107597G>T	ENST00000409195.1	+	9	9784	c.9695G>T	c.(9694-9696)aGg>aTg	p.R3232M	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R3010M|XIRP2_ENST00000295237.9_Missense_Mutation_p.R3232M|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3057					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACTCGTGGTAGGGACTCTCCA	0.443000													18	28					6.44725e-10	8.87617e-10	0.624587	1	0
SNHG14	104472715	broad.mit.edu	37	15	25438349	25438349	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:25438349G>T	ENST00000424208.1	+	0	1208				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						GCTAGGTGCTGAGCCCCTGGT	0.602000													4	13					0.00024832	0.000273297	0.150653	1	0
HMGB2	3148	broad.mit.edu	37	4	174254282	174254282	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:174254282G>A	ENST00000296503.5	-	3	1107	c.234C>T	c.(232-234)taC>taT	p.Y78Y	HMGB2_ENST00000446922.2_Silent_p.Y78Y|HMGB2_ENST00000438704.2_Silent_p.Y78Y			P26583	HMGB2_HUMAN	high mobility group box 2	78					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGGGAGGAACGTAATTTTTCA	0.403000													21	93					0	0	0.639603	0	0
ANO4	121601	broad.mit.edu	37	12	101477501	101477501	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:101477501C>T	ENST00000392979.3	+	15	1697	c.1336C>T	c.(1336-1338)Cgg>Tgg	p.R446W	ANO4_ENST00000299222.9_Intron|ANO4_ENST00000392977.3_Missense_Mutation_p.R481W|ANO4_ENST00000550015.1_Intron	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	481						chloride channel complex	chloride channel activity	p.R446W(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CAAGAAAGAGCGGATGAATCC	0.378000										HNSCC(74;0.22)			21	82					0	0	0.667858	0	0
B4GALNT3	283358	broad.mit.edu	37	12	657269	657269	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:657269G>T	ENST00000266383.5	+	8	799		c.e8+1		B4GALNT3_ENST00000544638.1_Splice_Site	NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3							Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGAAGTTGCAGTGAGTTTCCT	0.602000													17	19					3.32936e-07	4.09265e-07	0.539581	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140793565	140793565	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140793565G>T	ENST00000398610.2	+	1	823	c.823G>T	c.(823-825)Gaa>Taa	p.E275*	PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1												p.E275K(1)		breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACAGGGACGAAGGTGCCAA	0.463000													7	11					1.12685e-05	1.30266e-05	0.307466	1	0
TNR	7143	broad.mit.edu	37	1	175332958	175332958	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:175332958C>A	ENST00000367674.1	-	13	3301	c.2593G>T	c.(2593-2595)Gat>Tat	p.D865Y	TNR_ENST00000263525.2_Missense_Mutation_p.D865Y	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	865	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TTTGGGGGATCAATTCCTACA	0.428000													22	65					1.32143e-28	2.64287e-28	0.706142	1	0
XKR4	114786	broad.mit.edu	37	8	56436146	56436146	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:56436146G>T	ENST00000327381.5	+	3	1413	c.1313G>T	c.(1312-1314)gGg>gTg	p.G438V		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	438						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			ATGGTGGTGGGGATTATCTAT	0.438000													38	160					9.84934e-19	1.71793e-18	0.853193	1	0
STIM1	6786	broad.mit.edu	37	11	4104572	4104572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4104572C>T	ENST00000300737.4	+	10	1887	c.1318C>T	c.(1318-1320)Cag>Tag	p.Q440*	STIM1_ENST00000533977.1_Nonsense_Mutation_p.Q267*|STIM1_ENST00000527651.1_Nonsense_Mutation_p.Q440*	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	440					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		CTGTGGCTTCCAGATTGTCAA	0.572000													9	84					0	0	0.361761	0	0
SLC22A7	10864	broad.mit.edu	37	6	43268951	43268951	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:43268951C>T	ENST00000372585.5	+	6	1001	c.906C>T	c.(904-906)gcC>gcT	p.A302A	SLC22A7_ENST00000372589.3_Silent_p.A300A|SLC22A7_ENST00000372574.3_Silent_p.A300A|SLC22A7_ENST00000487175.1_3'UTR	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	302						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			TCCACTGTGCCAGGCTCAATG	0.582000													44	87					0	0	0.853193	0	0
PHC2	1912	broad.mit.edu	37	1	33790505	33790505	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:33790505C>T	ENST00000257118.5	-	14	2591	c.2538G>A	c.(2536-2538)ctG>ctA	p.L846L	RP11-415J8.3_ENST00000587696.1_RNA|RP11-415J8.3_ENST00000588828.1_RNA|RP11-415J8.3_ENST00000457957.2_RNA|PHC2_ENST00000419414.2_Silent_p.L847L|PHC2_ENST00000431992.1_Silent_p.L817L|PHC2_ENST00000373422.3_Silent_p.L452L|PHC2_ENST00000373418.3_Silent_p.L311L|PHC2_ENST00000485928.1_5'UTR	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	846	SAM.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CGTAGATCTTCAGGGCGGGCC	0.627000													8	57					0	0	0.307466	0	0
PIEZO2	63895	broad.mit.edu	37	18	10680288	10680288	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:10680288C>A	ENST00000302079.6	-	47	7331	c.7332G>T	c.(7330-7332)tgG>tgT	p.W2444C	PIEZO2_ENST00000285141.4_Missense_Mutation_p.W299C|PIEZO2_ENST00000503781.3_Missense_Mutation_p.W2507C|PIEZO2_ENST00000538948.1_Missense_Mutation_p.W464C|PIEZO2_ENST00000580640.1_Missense_Mutation_p.W2532C|PIEZO2_ENST00000581680.1_5'UTR			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2507						integral to membrane	ion channel activity										GGCTGATGGTCCACAAAGAAT	0.408000													32	46					8.73648e-17	1.45248e-16	0.796494	1	0
ZNF566	84924	broad.mit.edu	37	19	36940215	36940215	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:36940215C>A	ENST00000454319.1	-	5	1058	c.924G>T	c.(922-924)ggG>ggT	p.G308G	ZNF566_ENST00000493391.1_Silent_p.G203G|ZNF566_ENST00000434377.2_Silent_p.G307G|ZNF566_ENST00000392170.2_Silent_p.G308G|ZNF566_ENST00000424129.2_Silent_p.G307G	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					AGGGTTTTTCCCCAGTATGAA	0.398000													41	29					2.51966e-14	3.96157e-14	0.870114	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873757	91873757	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:91873757G>T	ENST00000373094.1	+	7	4707	c.3862G>T	c.(3862-3864)Ggg>Tgg	p.G1288W	PCDH11X_ENST00000361655.2_Missense_Mutation_p.G1270W|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000298274.8_Missense_Mutation_p.G1251W|PCDH11X_ENST00000373097.1_Missense_Mutation_p.G1278W|PCDH11X_ENST00000373088.1_Missense_Mutation_p.G1251W|PCDH11X_ENST00000406881.1_Missense_Mutation_p.G1280W	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1288					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AGGTGCTGATGGGCTATGCTC	0.478000													63	171					2.0493e-37	4.35794e-37	0.870114	1	0
KIRREL	55243	broad.mit.edu	37	1	158046021	158046021	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158046021G>C	ENST00000368173.3	+	2	575	c.171G>C	c.(169-171)ggG>ggC	p.G57G	KIRREL_ENST00000416935.2_Intron|KIRREL_ENST00000392272.2_Silent_p.G57G|KIRREL_ENST00000359209.6_Silent_p.G57G|KIRREL_ENST00000360089.4_5'UTR	NM_018240.5	NP_060710.3	Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	57	Ig-like C2-type 1.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					CCAAGGACGGGCTGGCCCTGG	0.617000													17	130					0	0	0.608945	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904765	144904765	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:144904765G>T	ENST00000370490.1	+	1	5077	c.822G>T	c.(820-822)agG>agT	p.R274S	SLITRK2_ENST00000447897.2_Missense_Mutation_p.R274S|SLITRK2_ENST00000413937.2_Missense_Mutation_p.R274S|SLITRK2_ENST00000434188.2_Missense_Mutation_p.R274S|SLITRK2_ENST00000428560.2_Missense_Mutation_p.R274S			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	274						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTCAGAGGGGCAGCCATG	0.557000													20	90					3.7963e-18	6.53075e-18	0.654019	1	0
RGS7	6000	broad.mit.edu	37	1	241261965	241261965	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:241261965C>A	ENST00000366565.1	-	3	557		c.e3+1		RGS7_ENST00000366564.1_Splice_Site|RGS7_ENST00000366562.4_Splice_Site|RGS7_ENST00000348120.2_Splice_Site|RGS7_ENST00000331110.7_Splice_Site|RGS7_ENST00000407727.1_Splice_Site|RGS7_ENST00000401882.1_Splice_Site|RGS7_ENST00000366563.1_Splice_Site|RGS7_ENST00000446183.2_Splice_Site	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7						G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TGCAGACTTACCAGAGAAGAC	0.403000													19	20					1.10513e-12	1.66389e-12	0.624587	1	0
RC3H2	54542	broad.mit.edu	37	9	125643034	125643034	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:125643034T>A	ENST00000373670.1	-	5	1399	c.799A>T	c.(799-801)Aag>Tag	p.K267*	RC3H2_ENST00000357244.2_Nonsense_Mutation_p.K267*|RC3H2_ENST00000335387.5_Nonsense_Mutation_p.K267*|RC3H2_ENST00000423239.2_Nonsense_Mutation_p.K267*|RC3H2_ENST00000373665.2_Nonsense_Mutation_p.K267*			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	267						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						AATTCCTCCTTCAGCTGCATT	0.408000													13	34					0	0	0.500413	0	0
CAPN11	11131	broad.mit.edu	37	6	44151460	44151460	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:44151460A>T	ENST00000398776.1	+	22	2191	c.2153A>T	c.(2152-2154)gAc>gTc	p.D718V	CAPN11_ENST00000542245.1_Missense_Mutation_p.D718V	NM_007058.3	NP_008989.2	Q9UMQ6	CAN11_HUMAN	calpain 11	718	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTAACCATGGACCCCAAGAAT	0.532000													12	48					0	0	0.411799	0	0
KCNC2	3747	broad.mit.edu	37	12	75444450	75444450	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:75444450G>T	ENST00000549446.1	-	3	2015	c.1335C>A	c.(1333-1335)ccC>ccA	p.P445P	KCNC2_ENST00000540018.1_Silent_p.P445P|KCNC2_ENST00000341669.3_Silent_p.P445P|KCNC2_ENST00000548513.1_Silent_p.P445P|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000550433.1_Silent_p.P445P|KCNC2_ENST00000393288.2_Silent_p.P445P|KCNC2_ENST00000350228.2_Silent_p.P445P|KCNC2_ENST00000298972.1_Silent_p.P445P	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	445					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						ACCATGTTTGGGGGTACATAT	0.507000													8	33					2.17888e-05	2.49279e-05	0.335167	1	0
STK31	56164	broad.mit.edu	37	7	23811864	23811864	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:23811864A>G	ENST00000354639.3	+	15	2327	c.1863A>G	c.(1861-1863)agA>agG	p.R621R	STK31_ENST00000355870.3_Silent_p.R644R|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.R621R|STK31_ENST00000433467.2_Silent_p.R644R	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	644			N -> K (in dbSNP:rs10263079).	NKS -> KKI (in Ref. 1; AAK31978).			ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CTCTACTCAGATGGAAATTGG	0.333000													24	78					0	0	0.681144	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458340	45458340	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:45458340C>T	ENST00000548424.1	+	0	448																											GTTCTTGGCTCCAGCTGCCTG	0.488000													9	15					0	0	0.387290	0	0
MROH5	389690	broad.mit.edu	37	8	142446053	142446053	+	RNA	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:142446053A>T	ENST00000606664.1	+	0	1409				MROH5_ENST00000430863.1_RNA																							GTGTAGGAGCAGGGGCACCAT	0.677000													53	26					0	0	0.870114	0	0
CUL1	8454	broad.mit.edu	37	7	148454128	148454128	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:148454128G>T	ENST00000325222.4	+	4	648	c.369G>T	c.(367-369)tgG>tgT	p.W123C	CUL1_ENST00000409469.1_Missense_Mutation_p.W123C|CUL1_ENST00000602748.1_Missense_Mutation_p.W123C	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	123					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CTCAACAATGGGAAGATTATC	0.368000													41	75					9.84934e-19	1.71793e-18	0.853193	1	0
AMER1	139285	broad.mit.edu	37	X	63410391	63410391	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:63410391C>T	ENST00000330258.3	-	2	3048	c.2776G>A	c.(2776-2778)Gaa>Aaa	p.E926K	AMER1_ENST00000374869.3_Intron|AMER1_ENST00000403336.1_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TCTGAATCTTCCTGCTGGGCC	0.572000													11	41					0	0	0.457914	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	169593	169593	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:169593C>A	ENST00000283426.6	+	12	2597	c.2547C>A	c.(2545-2547)caC>caA	p.H849Q		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	849	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GGAAGCACCACGTTATTTTCG	0.562000													72	397					1.91593e-42	4.15412e-42	0.870114	1	0
DOCK11	139818	broad.mit.edu	37	X	117783002	117783002	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:117783002G>T	ENST00000276204.6	+	41	4567	c.4493G>T	c.(4492-4494)aGg>aTg	p.R1498M	DOCK11_ENST00000276202.7_Missense_Mutation_p.R1498M			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1498					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AGCTCAACCAGGAATGAAGCA	0.368000													10	101					9.31168e-06	1.08377e-05	0.435327	1	0
PLCB4	5332	broad.mit.edu	37	20	9417690	9417690	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:9417690C>T	ENST00000378501.2	+	26	2634	c.2619C>T	c.(2617-2619)gaC>gaT	p.D873D	PLCB4_ENST00000414679.2_Silent_p.D885D|PLCB4_ENST00000278655.4_Silent_p.D873D|PLCB4_ENST00000378493.1_Silent_p.D873D|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Silent_p.D885D|PLCB4_ENST00000334005.3_Silent_p.D873D	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	873					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CCAAAAATGACAAGAAAGGAA	0.493000													9	16					0	0	0.361761	0	0
MCF2	4168	broad.mit.edu	37	X	138697087	138697087	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:138697087G>T	ENST00000520602.1	-	13	1781	c.1496C>A	c.(1495-1497)cCt>cAt	p.P499H	MCF2_ENST00000414978.1_Missense_Mutation_p.P499H|MCF2_ENST00000370573.4_Missense_Mutation_p.P439H|MCF2_ENST00000370576.4_Missense_Mutation_p.P439H|MCF2_ENST00000483690.1_5'UTR|MCF2_ENST00000536274.1_Missense_Mutation_p.P400H|MCF2_ENST00000370578.4_Missense_Mutation_p.P584H|MCF2_ENST00000519895.1_Missense_Mutation_p.P499H|MCF2_ENST00000338585.6_Missense_Mutation_p.P439H			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	439	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					CAAATTTTCAGGTGTGGGTAC	0.378000													52	176					2.93687e-30	5.94322e-30	0.870114	1	0
A2ML1	144568	broad.mit.edu	37	12	9004533	9004533	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:9004533C>A	ENST00000299698.7	+	19	2568	c.2388C>A	c.(2386-2388)ctC>ctA	p.L796L	A2ML1_ENST00000539547.1_Silent_p.L305L	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	640						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						ACCTGACTCTCCCTTACTCAG	0.498000													21	104					1.75199e-13	2.69823e-13	0.717897	1	0
CHN2	1124	broad.mit.edu	37	7	29546843	29546843	+	Splice_Site	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:29546843G>A	ENST00000222792.6	+	11	1521		c.e11-1		CHN2_ENST00000410098.1_Splice_Site|CHN2_ENST00000409041.4_Splice_Site|CHN2_ENST00000424025.2_Splice_Site|CHN2_ENST00000421775.2_Splice_Site|CHN2_ENST00000439711.2_Intron|CHN2_ENST00000435288.2_Intron|CHN2_ENST00000546235.1_Splice_Site|CHN2_ENST00000539389.1_Splice_Site|CHN2_ENST00000539406.1_Splice_Site|CHN2_ENST00000495789.2_Splice_Site	NM_004067.2	NP_004058.1	P52757	CHIO_HUMAN	chimerin 2						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			breast(2)|endometrium(3)|large_intestine(2)|lung(12)|ovary(2)|urinary_tract(2)	23						TTGTTTTTCAGATGGTGAAAA	0.398000													16	59					0	0	0.592651	0	0
CHIAP2	149620	broad.mit.edu	37	1	111826844	111826844	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:111826844G>A	ENST00000369743.4	+	0	1554					NR_003928.1																						CCTATACCAGGCAGTCTGGGT	0.498000													4	7					0	0	0.184627	0	0
NOTCH2	4853	broad.mit.edu	37	1	120465262	120465262	+	Missense_Mutation	SNP	C	C	T	rs17024517	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:120465262C>T	ENST00000256646.2	-	27	5218	c.4999G>A	c.(4999-5001)Gtc>Atc	p.V1667I	NOTCH2_ENST00000493703.1_5'UTR	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1667	Negative regulatory region (NRR).		V -> F (in dbSNP:rs17024517).		anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACTCACTGACGACAGACACA	0.517000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				17	101					0	0	0.539581	0	0
SYCE1	93426	broad.mit.edu	37	10	135371370	135371370	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:135371370G>C	ENST00000368517.3	-	6	402	c.264C>G	c.(262-264)caC>caG	p.H88Q	SYCE1_ENST00000432597.2_Missense_Mutation_p.H88Q|SYCE1_ENST00000343131.5_Missense_Mutation_p.H124Q|SPRN_ENST00000541506.1_Intron	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	124					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GCTCTTACCTGTGTGCCTCAC	0.517000													16	31					0	0	0.592651	0	0
KCNH8	131096	broad.mit.edu	37	3	19559531	19559531	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:19559531G>T	ENST00000328405.2	+	15	2850	c.2584G>T	c.(2584-2586)Gag>Tag	p.E862*		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	862						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CAAAGCAGAGGAGACCAAGCA	0.403000													8	24					0.307466	0.309605	0.307466	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298730	125298730	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:125298730G>T	ENST00000538699.1	-	2	1258	c.1178C>A	c.(1177-1179)tCc>tAc	p.S393Y	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.S393Y	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	393										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CCCCGGCATGGAGTCCAGGCT	0.612000													9	43					4.68919e-08	5.99121e-08	0.361761	1	0
MORC4	79710	broad.mit.edu	37	X	106185961	106185961	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:106185961C>G	ENST00000355610.4	-	15	2434	c.2160G>C	c.(2158-2160)gaG>gaC	p.E720D	MORC4_ENST00000535534.1_Missense_Mutation_p.E468D|MORC4_ENST00000255495.7_Missense_Mutation_p.E720D	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	720							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						CTTTTCGTCTCTCAGCAAGCT	0.507000													12	123					0	0	0.457914	0	0
ZNF461	92283	broad.mit.edu	37	19	37147375	37147375	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:37147375C>A	ENST00000588268.1	-	4	434	c.207G>T	c.(205-207)agG>agT	p.R69S	ZNF461_ENST00000360357.4_Missense_Mutation_p.R69S	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R69S(1)		endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CTGTCTCTTCCCTCACAACCA	0.488000													21	17					3.1745e-13	4.84542e-13	0.729181	1	0
SATB2	23314	broad.mit.edu	37	2	200137080	200137080	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:200137080C>G	ENST00000443023.1	-	10	3344	c.1879G>C	c.(1879-1881)Gtg>Ctg	p.V627L	SATB2_ENST00000260926.5_Missense_Mutation_p.V686L|SATB2_ENST00000428695.1_Missense_Mutation_p.V568L|SATB2_ENST00000457245.1_Missense_Mutation_p.V686L|SATB2_ENST00000417098.1_Missense_Mutation_p.V686L			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	686						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TATTCAGCCACGTCCACCGCG	0.562000													46	50					0	0	0.870114	0	0
TTN	7273	broad.mit.edu	37	2	179622524	179622524	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:179622524T>A	ENST00000589042.1	-	45	10647	c.10423A>T	c.(10423-10425)Agg>Tgg	p.R3475W	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R3429W|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3163							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGCACCCTGAGGCTTGAC	0.473000													18	89					0	0	0.639603	0	0
MEIS1	4211	broad.mit.edu	37	2	66667699	66667699	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:66667699C>T	ENST00000488550.1	+	4	686	c.387C>T	c.(385-387)cgC>cgT	p.R129R	MEIS1_ENST00000272369.9_Silent_p.R129R|MEIS1-AS1_ENST00000454595.1_RNA|MEIS1_ENST00000495021.2_Silent_p.R64R|MEIS1_ENST00000444274.2_Silent_p.R97R|MEIS1_ENST00000560281.2_Silent_p.R129R|MEIS1_ENST00000398506.2_Silent_p.R127R|MEIS1_ENST00000407092.2_Silent_p.R129R			O00470	MEIS1_HUMAN	Meis homeobox 1	129							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						TTTAGATTCGCGCAGAAAAAC	0.483000													7	25					0	0	0.307466	0	0
CLCA1	1179	broad.mit.edu	37	1	86951148	86951148	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:86951148T>A	ENST00000234701.3	+	7	1209	c.858T>A	c.(856-858)acT>acA	p.T286T	CLCA1_ENST00000394711.1_Silent_p.T286T			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	286					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AGAAAACCACTCCTATGACAA	0.423000													6	188					0	0	0.248553	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271526	36271526	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:36271526C>G	ENST00000007510.4	+	9	889	c.745C>G	c.(745-747)Cgg>Ggg	p.R249G	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.R113G|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.R249G			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	249					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CTTCACAGAGCGGCCAGGTCC	0.647000													58	236					0	0	0.870114	0	0
KIF1A	547	broad.mit.edu	37	2	241656811	241656811	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:241656811G>T	ENST00000498729.2	-	49	5592	c.5346C>A	c.(5344-5346)tcC>tcA	p.S1782S	KIF1A_ENST00000320389.7_Silent_p.S1681S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1681					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACCTCCTTCTGGAGAGCTTGG	0.657000													108	36					9.56113e-55	2.12696e-54	0.870114	1	0
MUC16	94025	broad.mit.edu	37	19	9028327	9028327	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:9028327G>T	ENST00000397910.4	-	11	36668	c.36465C>A	c.(36463-36465)ctC>ctA	p.L12155L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12157	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCCAGTCCGAGGTCTTCAG	0.557000													71	84					2.10938e-32	4.32446e-32	0.870114	1	0
FAM90A1	55138	broad.mit.edu	37	12	8374540	8374540	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:8374540C>G	ENST00000538603.1	-	7	1831	c.1273G>C	c.(1273-1275)Gct>Cct	p.A425P	FAM90A1_ENST00000307435.6_Missense_Mutation_p.A425P	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	425							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGGCTCTGAGCGAGGAAGGCT	0.587000													11	19					0	0	0.479597	0	0
HNRNPR	10236	broad.mit.edu	37	1	23660105	23660105	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:23660105C>A	ENST00000478691.1	-	4	372	c.101G>T	c.(100-102)gGt>gTt	p.G34V	HNRNPR_ENST00000374612.1_Missense_Mutation_p.G135V|HNRNPR_ENST00000606561.1_Intron|HNRNPR_ENST00000427764.2_Intron|HNRNPR_ENST00000426846.2_Missense_Mutation_p.G34V|HNRNPR_ENST00000302271.6_Missense_Mutation_p.G135V|HNRNPR_ENST00000374616.3_Missense_Mutation_p.G135V	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	135	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		CAGAGTATAACCAGTTCTCTC	0.423000													15	43					1.99824e-07	2.49217e-07	0.520397	1	0
WDR49	151790	broad.mit.edu	37	3	167272470	167272470	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:167272470C>A	ENST00000453925.2	-	6	961	c.927G>T	c.(925-927)agG>agT	p.R309S	WDR49_ENST00000308378.3_Splice_Site|WDR49_ENST00000476376.1_Splice_Site|WDR49_ENST00000479765.1_Intron			Q8IV35	WDR49_HUMAN	WD repeat domain 49	255										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CATAATCATACCTCTCCCAGC	0.328000													27	66					1.88708e-17	3.19379e-17	0.729181	1	0
LAS1L	81887	broad.mit.edu	37	X	64754486	64754486	+	Missense_Mutation	SNP	G	G	A	rs113345668		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:64754486G>A	ENST00000374811.3	-	1	150	c.110C>T	c.(109-111)tCg>tTg	p.S37L	LAS1L_ENST00000374807.5_Missense_Mutation_p.S37L|LAS1L_ENST00000374804.5_Missense_Mutation_p.S37L|LAS1L_ENST00000312391.8_Missense_Mutation_p.S37L	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	37						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						GCCGTGGGCCGAGAGTGGCAA	0.612000													4	6					0	0	0.150653	0	0
SPDYA	245711	broad.mit.edu	37	2	29052092	29052092	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:29052092G>A	ENST00000334056.5	+	6	648	c.459G>A	c.(457-459)tgG>tgA	p.W153*	SPDYA_ENST00000379579.4_Nonsense_Mutation_p.W153*|SPDYA_ENST00000462832.1_3'UTR	NM_182756.3	NP_877433.2	Q5MJ70	SPDYA_HUMAN	speedy/RINGO cell cycle regulator family member A	153	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					GGAAAAACTGGAGAAAATTGT	0.393000													13	24					0	0	0.479597	0	0
FAM47B	170062	broad.mit.edu	37	X	34962737	34962737	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:34962737C>A	ENST00000329357.5	+	1	1825	c.1789C>A	c.(1789-1791)Cta>Ata	p.L597I		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	597										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GGATTTCATTCTAAGCAAGGG	0.453000													28	81					3.57733e-08	4.58619e-08	0.740014	1	0
VPS13A	23230	broad.mit.edu	37	9	79936430	79936430	+	Silent	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:79936430A>C	ENST00000360280.3	+	44	5858	c.5598A>C	c.(5596-5598)ggA>ggC	p.G1866G	VPS13A_ENST00000376636.3_Silent_p.G1827G|VPS13A_ENST00000376634.4_Silent_p.G1866G|VPS13A_ENST00000357409.5_Silent_p.G1866G	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1866					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTGCCACTGGATCTTCAGCTG	0.338000													7	48					0	0	0.307466	0	0
STX2	2054	broad.mit.edu	37	12	131306330	131306330	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:131306330C>T	ENST00000261653.6	-	3	275	c.109G>A	c.(109-111)Gag>Aag	p.E37K	STX2_ENST00000392373.2_Missense_Mutation_p.E37K	NM_001980.3	NP_001971.2	P32856	STX2_HUMAN	syntaxin 2	37					acrosome reaction|ectoderm development|intracellular protein transport|organ morphogenesis|signal transduction	basolateral plasma membrane|integral to membrane|microsome|soluble fraction	calcium-dependent protein binding|SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)	16	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.79e-06)|all cancers(50;5.27e-05)|Epithelial(86;5.29e-05)		CTAATCTCCTCCACCTAGGAG	0.378000													6	19					0	0	0.248553	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090289	238090289	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:238090289C>A	ENST00000450451.1	+	0	1795					NR_027247.2																						AGGACTCCTACGTGGGCGACA	0.602000													9	27					5.50884e-06	6.43952e-06	0.411799	1	0
FNDC1	84624	broad.mit.edu	37	6	159654060	159654060	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:159654060G>A	ENST00000297267.9	+	11	2716	c.2516G>A	c.(2515-2517)cGg>cAg	p.R839Q	FNDC1_ENST00000340366.6_Missense_Mutation_p.R776Q	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	839						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCATTGGGCGGGGACCTCGG	0.637000													4	10					0	0	0.248553	0	0
PRLR	5618	broad.mit.edu	37	5	35065591	35065591	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:35065591G>A	ENST00000382002.5	-	10	1895	c.1469C>T	c.(1468-1470)aCg>aTg	p.T490M	PRLR_ENST00000310101.5_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Missense_Mutation_p.T389M|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000231423.3_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.T389M|PRLR_ENST00000348262.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	490					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CAGCCAGGGCGTATCCTGGTC	0.483000													4	134					0	0	0.150653	0	0
GCDH	2639	broad.mit.edu	37	19	13007233	13007233	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:13007233G>T	ENST00000222214.5	+	8	1061	c.850G>T	c.(850-852)Ggg>Tgg	p.G284W	GCDH_ENST00000422947.2_Missense_Mutation_p.G240W|GCDH_ENST00000457854.1_Missense_Mutation_p.G284W|GCDH_ENST00000591470.1_Missense_Mutation_p.G284W			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	284					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						ATCCAGCCTGGGGGTAAGTGG	0.637000													4	17					0.184627	0.18651	0.184627	1	0
CKAP5	9793	broad.mit.edu	37	11	46842770	46842770	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:46842770T>A	ENST00000529230.1	-	2	59	c.13A>T	c.(13-15)Agt>Tgt	p.S5C	CKAP5_ENST00000354558.3_Missense_Mutation_p.S5C|CKAP5_ENST00000415402.1_Missense_Mutation_p.S5C|CKAP5_ENST00000312055.5_Missense_Mutation_p.S5C			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	5					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						AACCACTCACTGTCATCTCCC	0.413000													28	208					0	0	0.779181	0	0
CLDN18	51208	broad.mit.edu	37	3	137749854	137749854	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:137749854C>A	ENST00000183605.5	+	5	883	c.657C>A	c.(655-657)gcC>gcA	p.A219A	CLDN18_ENST00000343735.4_Silent_p.A219A	NM_016369.3	NP_057453.1	P56856	CLD18_HUMAN	claudin 18	219					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						ACAGTGTTGCCTACAAGCCTG	0.468000													42	68					5.34276e-22	9.90647e-22	0.870114	1	0
NRAS	4893	broad.mit.edu	37	1	115251276	115251276	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:115251276C>A	ENST00000369535.4	-	5	704		c.e5-1			NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog						activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity			NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAACACCCTATAAAAGGA	0.378000		50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			17	30					7.07596e-05	7.95993e-05	0.539581	1	0
BRPF1	7862	broad.mit.edu	37	3	9787290	9787290	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:9787290C>T	ENST00000383829.2	+	11	3506	c.3102C>T	c.(3100-3102)ccC>ccT	p.P1034P	BRPF1_ENST00000424362.1_Silent_p.P1027P|BRPF1_ENST00000302054.3_Silent_p.P1028P|BRPF1_ENST00000457855.1_Silent_p.P1028P|BRPF1_ENST00000433861.2_Silent_p.P933P	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	1028	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					GGGGCAAACCCTCCTTCTCTC	0.597000													11	46					0	0	0.435327	0	0
XPO1	7514	broad.mit.edu	37	2	61719812	61719812	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:61719812C>A	ENST00000401558.2	-	14	2183	c.1456G>T	c.(1456-1458)Ggt>Tgt	p.G486C	XPO1_ENST00000404992.2_Missense_Mutation_p.G486C|XPO1_ENST00000406957.1_Missense_Mutation_p.G486C	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	486	Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			CACTCTGTACCATTCACTTGA	0.358000			Mis		CLL								23	73					2.65835e-16	4.37708e-16	0.717897	1	0
PTPRD	5789	broad.mit.edu	37	9	8521408	8521408	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:8521408G>T	ENST00000381196.4	-	17	1373	c.830C>A	c.(829-831)aCa>aAa	p.T277K	PTPRD_ENST00000540109.1_Missense_Mutation_p.T277K|PTPRD_ENST00000358503.5_Missense_Mutation_p.T264K|PTPRD_ENST00000537002.1_Missense_Mutation_p.T274K|PTPRD_ENST00000356435.5_Missense_Mutation_p.T277K|PTPRD_ENST00000486161.1_Missense_Mutation_p.T277K|PTPRD_ENST00000360074.4_Missense_Mutation_p.T264K|PTPRD_ENST00000397606.3_Missense_Mutation_p.T267K|PTPRD_ENST00000397617.3_Missense_Mutation_p.T267K|PTPRD_ENST00000355233.5_Missense_Mutation_p.T277K|PTPRD_ENST00000397611.3_Missense_Mutation_p.T274K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	277	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATCTTCAGGTGTCAGATCTTC	0.453000										TSP Lung(15;0.13)			48	146					3.8128e-34	7.89405e-34	0.870114	1	0
PCDH15	65217	broad.mit.edu	37	10	55582336	55582336	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:55582336G>T	ENST00000361849.3	-	34	5550	c.5156C>A	c.(5155-5157)aCa>aAa	p.T1719K	PCDH15_ENST00000395430.1_Missense_Mutation_p.T1714K|PCDH15_ENST00000437009.1_Missense_Mutation_p.T1648K|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.T1677K|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.T1694K|PCDH15_ENST00000320301.6_Missense_Mutation_p.T1717K|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395440.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1717					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACAAATAGGTGTCTCTCTCCT	0.418000										HNSCC(58;0.16)			5	18					1.23904e-05	1.42622e-05	0.184627	1	0
FBN2	2201	broad.mit.edu	37	5	127674724	127674724	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:127674724G>A	ENST00000508053.1	-	32	4347	c.3373C>T	c.(3373-3375)Ctc>Ttc	p.L1125F	FBN2_ENST00000262464.4_Missense_Mutation_p.L1125F|FBN2_ENST00000508989.1_Missense_Mutation_p.L1092F|FBN2_ENST00000507835.1_5'UTR			P35556	FBN2_HUMAN	fibrillin 2	1125	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGCCACAGAGGTCAGGAGAA	0.463000													29	26					0	0	0.804634	0	0
ATAD2	29028	broad.mit.edu	37	8	124408584	124408584	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:124408584C>A	ENST00000287394.5	-	1	121	c.14G>T	c.(13-15)cGc>cTc	p.R5L	ATAD2_ENST00000521903.1_Intron	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAAGCTGCTGCGGAGAACCAC	0.662000													4	26					3.59834e-05	4.08202e-05	0.217242	1	0
NAP1L2	4674	broad.mit.edu	37	X	72433312	72433312	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:72433312C>A	ENST00000373517.3	-	1	1372	c.1017G>T	c.(1015-1017)aaG>aaT	p.K339N	NAP1L2_ENST00000536638.1_Missense_Mutation_p.K197N	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	339					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					AAGTGACATTCTTTCCTTCAT	0.398000													17	52					0.00400662	0.00425294	0.500413	1	0
SMOC1	64093	broad.mit.edu	37	14	70480189	70480189	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:70480189G>C	ENST00000381280.4	+	10	1280	c.1027G>C	c.(1027-1029)Gcg>Ccg	p.A343P	SMOC1_ENST00000361956.3_Missense_Mutation_p.A343P	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	343					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		TAACTCAGCAGCGCCCACTGG	0.507000											OREG0022771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	134					0	0	0.717897	0	0
MYO1F	4542	broad.mit.edu	37	19	8601171	8601171	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:8601171C>T	ENST00000338257.8	-	19	2275	c.2008G>A	c.(2008-2010)Ggg>Agg	p.G670R		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	670	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TTGGTGCTCCCCATCTGGTAC	0.612000													64	34					0	0	0.870114	0	0
APBA3	9546	broad.mit.edu	37	19	3752855	3752855	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:3752855T>A	ENST00000316757.3	-	7	1345	c.1145A>T	c.(1144-1146)gAc>gTc	p.D382V		NM_004886.3	NP_004877.1	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 3	382					intracellular signal transduction|protein transport	intracellular|membrane	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTCCAGGTCCCCATTATG	0.677000													44	14					0	0	0.870114	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316523	30316523	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:30316523T>G	ENST00000375377.1	-	3	2655	c.2554A>C	c.(2554-2556)Agc>Cgc	p.S852R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	852	Ser-rich.			S -> G (in Ref. 6; AAH47548).						breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ctgctgctgctgctactgctg	0.562000													4	64					0	0	0.184627	0	0
SGSM1	129049	broad.mit.edu	37	22	25313649	25313649	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:25313649C>G	ENST00000400358.4	+	23	3010	c.2953C>G	c.(2953-2955)Ctg>Gtg	p.L985V	SGSM1_ENST00000400359.4_Missense_Mutation_p.L1040V	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1040	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GCTGTTTGAGCTGATGCATCA	0.498000													21	63					0	0	0.693898	0	0
BLOC1S5	63915	broad.mit.edu	37	6	8064638	8064638	+	Translation_Start_Site	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:8064638C>T	ENST00000397457.2	-	0	9				EEF1E1-MUTED_ENST00000397456.2_Intron	NM_001199323.1|NM_201280.2	NP_001186252.1|NP_958437.1			biogenesis of lysosomal organelles complex-1, subunit 5, muted																		CCCGCGGCCACGCTGCGCCTG	0.647000													6	12					0	0	0.217242	0	0
FLG	2312	broad.mit.edu	37	1	152280947	152280947	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152280947G>T	ENST00000368799.1	-	3	6450	c.6415C>A	c.(6415-6417)Cgt>Agt	p.R2139S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2139	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGTGTCCACGAATGGTGTCC	0.577000									Ichthyosis				135	480					1.77796e-62	3.99298e-62	0.870114	1	0
DLG3	1741	broad.mit.edu	37	X	69669599	69669599	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:69669599G>T	ENST00000194900.4	+	5	988	c.647G>T	c.(646-648)cGg>cTg	p.R216L	DLG3_ENST00000374360.3_Missense_Mutation_p.R198L			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	198	PDZ 1.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GTACACAGCCGGGCGGTGGAG	0.637000													6	14					1.12685e-05	1.30266e-05	0.307466	1	0
SCN5A	6331	broad.mit.edu	37	3	38627394	38627394	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:38627394G>T	ENST00000413689.1	-	16	2768	c.2575C>A	c.(2575-2577)Cag>Aag	p.Q859K	SCN5A_ENST00000333535.4_Missense_Mutation_p.Q859K|SCN5A_ENST00000423572.2_Missense_Mutation_p.Q859K|SCN5A_ENST00000451551.2_Missense_Mutation_p.Q859K|SCN5A_ENST00000450102.2_Missense_Mutation_p.Q859K|SCN5A_ENST00000449557.2_Missense_Mutation_p.Q859K|SCN5A_ENST00000443581.1_Missense_Mutation_p.Q859K|SCN5A_ENST00000425664.1_Missense_Mutation_p.Q859K|SCN5A_ENST00000414099.2_Missense_Mutation_p.Q859K|SCN5A_ENST00000455624.2_Missense_Mutation_p.Q859K	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	859					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CCAAAGAGCTGCATGCCCACC	0.542000													43	59					1.31131e-34	2.73297e-34	0.864702	1	0
SCARA3	51435	broad.mit.edu	37	8	27528417	27528417	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:27528417G>T	ENST00000301904.3	+	6	1390	c.1369_splice	c.e6-1	p.G457_splice	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	457	Collagen-like 1.				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		CCAACCTCAGGTGCCCCCGGC	0.657000													30	56					6.1244e-12	9.07569e-12	0.834066	1	0
TAOK2	9344	broad.mit.edu	37	16	29998181	29998181	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:29998181G>T	ENST00000308893.4	+	16	3631	c.2588G>T	c.(2587-2589)gGc>gTc	p.G863V	TAOK2_ENST00000543033.1_Missense_Mutation_p.G750V|TAOK2_ENST00000416441.2_Missense_Mutation_p.G690V|TAOK2_ENST00000279394.3_Intron	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	863	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						AGCATTGTTGGCCAGGAGGAG	0.577000													11	17					0.000673444	0.000729241	0.361761	1	0
GCDH	2639	broad.mit.edu	37	19	13007234	13007234	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:13007234G>T	ENST00000222214.5	+	8	1062	c.852_splice	c.e8+1	p.G284_splice	GCDH_ENST00000422947.2_Splice_Site_p.G240_splice|GCDH_ENST00000457854.1_Splice_Site_p.G284_splice|GCDH_ENST00000591470.1_Splice_Site_p.G284_splice			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	284					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						TCCAGCCTGGGGGTAAGTGGC	0.637000													4	16					0.184627	0.18651	0.184627	1	0
PDHX	8050	broad.mit.edu	37	11	34979028	34979028	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:34979028T>C	ENST00000448838.3	+	4	637	c.395T>C	c.(394-396)gTa>gCa	p.V132A	PDHX_ENST00000227868.4_Missense_Mutation_p.V147A|PDHX_ENST00000430469.2_Intron	NM_001135024.1|NM_003477.2	NP_001128496.1|NP_003468.2	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	147					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	16	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			CCCAAAGACGTAGGTCCTCCA	0.443000													8	57					0	0	0.335167	0	0
ZNF208	7757	broad.mit.edu	37	19	22154550	22154550	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22154550A>G	ENST00000397126.4	-	4	3434	c.3286T>C	c.(3286-3288)Tgg>Cgg	p.W1096R	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTGAGGACCAGTTGAAAGCT	0.428000													12	63					0	0	0.411799	0	0
ETNPPL	64850	broad.mit.edu	37	4	109664968	109664968	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:109664968C>G	ENST00000296486.3	-	12	1502	c.1348G>C	c.(1348-1350)Gag>Cag	p.E450Q	ETNPPL_ENST00000510706.1_Missense_Mutation_p.E410Q|ETNPPL_ENST00000411864.2_Missense_Mutation_p.E444Q|ETNPPL_ENST00000512646.1_Missense_Mutation_p.E392Q	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase																		GGAGTATTCTCAGAGGTCACA	0.328000													8	32					0	0	0.335167	0	0
BPIFB6	128859	broad.mit.edu	37	20	31622634	31622634	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:31622634G>T	ENST00000349552.1	+	4	368	c.368G>T	c.(367-369)cGg>cTg	p.R123L		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	123						extracellular region	lipid binding										CGGCTTCTGCGGGATGAGGAG	0.582000													32	49					2.08457e-15	3.3474e-15	0.750413	1	0
PTPRD	5789	broad.mit.edu	37	9	8319939	8319939	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:8319939G>A	ENST00000381196.4	-	42	6105	c.5562C>T	c.(5560-5562)ttC>ttT	p.F1854F	PTPRD_ENST00000540109.1_Silent_p.F1854F|PTPRD_ENST00000358503.5_Silent_p.F1832F|PTPRD_ENST00000537002.1_Silent_p.F1444F|PTPRD_ENST00000356435.5_Silent_p.F1854F|PTPRD_ENST00000486161.1_Silent_p.F1447F|PTPRD_ENST00000360074.4_Silent_p.F1841F|PTPRD_ENST00000397606.3_Silent_p.F1447F|PTPRD_ENST00000397617.3_Silent_p.F1447F|PTPRD_ENST00000355233.5_Silent_p.F1448F|PTPRD_ENST00000397611.3_Silent_p.F1444F	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1854	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTAGCGTTATGAAGACTCCAG	0.448000										TSP Lung(15;0.13)			15	51					0	0	0.500413	0	0
MIR510	574515	broad.mit.edu	37	X	146353885	146353885	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:146353885C>A	ENST00000384909.1	-	0	41					NR_030237.1																						TTCAATCACACCTAATTACAT	0.393000													5	80					2.7689e-08	3.57167e-08	0.248553	1	0
PFDN2	5202	broad.mit.edu	37	1	161070589	161070589	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161070589C>T	ENST00000368010.3	-	4	433	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	PFDN2_ENST00000468311.1_5'UTR	NM_012394.3	NP_036526.2	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	117					'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding			lung(1)|skin(1)	2	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TCCCGGAATTCATTTAGTTCT	0.473000													30	126					0	0	0.769981	0	0
CSMD3	114788	broad.mit.edu	37	8	113564843	113564843	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:113564843T>A	ENST00000297405.5	-	26	4585	c.4341A>T	c.(4339-4341)gtA>gtT	p.V1447V	CSMD3_ENST00000455883.2_Silent_p.V1343V|CSMD3_ENST00000343508.3_Silent_p.V1407V|CSMD3_ENST00000352409.3_Silent_p.V1447V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1447	CUB 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTCCAGGATCTACCTCAATCA	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			3	49					0	0	0.150653	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779531	205779531	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:205779531C>T	ENST00000367137.3	-	2	1053	c.39G>A	c.(37-39)ctG>ctA	p.L13L		NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	13						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			CAGTCCCGTTCAGTTGGTGGA	0.592000											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	116					0	0	0.750413	0	0
NALCN	259232	broad.mit.edu	37	13	101881928	101881928	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:101881928C>A	ENST00000251127.6	-	13	1523	c.1442G>T	c.(1441-1443)cGa>cTa	p.R481L	NALCN_ENST00000376196.3_Missense_Mutation_p.R481L|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	481						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCGAACTACTCGGAGAACCTA	0.318000													196	86					6.9384e-91	1.58857e-90	0.870114	1	0
EXD3	54932	broad.mit.edu	37	9	140243959	140243959	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:140243959G>A	ENST00000340951.4	-	15	1714	c.1519C>T	c.(1519-1521)Cca>Tca	p.P507S	EXD3_ENST00000342129.4_Missense_Mutation_p.P187S	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	507					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						TCCACGGCTGGGGCTGGCACG	0.682000													13	27					0	0	0.539581	0	0
LPHN3	23284	broad.mit.edu	37	4	62775382	62775382	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:62775382C>A	ENST00000512091.1	+	11	2535	c.1788C>A	c.(1786-1788)gaC>gaA	p.D596E	LPHN3_ENST00000514996.1_Missense_Mutation_p.D596E|LPHN3_ENST00000509896.1_Missense_Mutation_p.D664E|LPHN3_ENST00000508693.1_Missense_Mutation_p.D664E|LPHN3_ENST00000506700.1_Missense_Mutation_p.D596E|LPHN3_ENST00000508946.1_Missense_Mutation_p.D596E|LPHN3_ENST00000506720.1_Missense_Mutation_p.D664E|LPHN3_ENST00000506746.1_Missense_Mutation_p.D664E|LPHN3_ENST00000511324.1_Missense_Mutation_p.D664E|LPHN3_ENST00000507625.1_Missense_Mutation_p.D664E|LPHN3_ENST00000504896.1_Missense_Mutation_p.D596E|LPHN3_ENST00000545650.1_Missense_Mutation_p.D596E|LPHN3_ENST00000514157.1_Missense_Mutation_p.D596E|LPHN3_ENST00000514591.1_Missense_Mutation_p.D596E|LPHN3_ENST00000507164.1_Missense_Mutation_p.D664E			Q9HAR2	LPHN3_HUMAN	latrophilin 3	596					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GGGCCATGGACCAGCTGGTAG	0.502000													6	11					0.0215528	0.0222625	0.217242	1	0
HAUS7	55559	broad.mit.edu	37	X	152720487	152720487	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:152720487G>T	ENST00000370212.3	-	9	984	c.985C>A	c.(985-987)Ccg>Acg	p.P329T	TREX2_ENST00000330912.2_5'UTR|HAUS7_ENST00000370219.3_Intron|HAUS7_ENST00000484394.1_5'UTR|TREX2_ENST00000370232.1_Intron|TREX2_ENST00000334497.2_Intron|HAUS7_ENST00000421080.2_3'UTR|HAUS7_ENST00000370211.4_Intron|TREX2_ENST00000338525.2_Intron			Q99871	HAUS7_HUMAN	HAUS augmin-like complex, subunit 7	312					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding			endometrium(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)	19						ACTAAAGCCGGCTTTTTAGGT	0.512000													5	98					0.00116845	0.00125586	0.217242	1	0
DGKK	139189	broad.mit.edu	37	X	50111965	50111965	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:50111965G>T	ENST00000376025.2	-	0	3848							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					GATGGTGTTAGAGGATCATCA	0.403000													12	18					1.3612e-06	1.64112e-06	0.479597	1	0
ZNF677	342926	broad.mit.edu	37	19	53740619	53740619	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:53740619G>T	ENST00000333952.4	-	5	1526	c.1361C>A	c.(1360-1362)aCt>aAt	p.T454N	ZNF677_ENST00000598513.1_Missense_Mutation_p.T454N			Q86XU0	ZN677_HUMAN	zinc finger protein 677	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TTTTTCTCCAGTGTGAATTCT	0.383000													18	17					6.94344e-10	9.5106e-10	0.539581	1	0
PPIL4	85313	broad.mit.edu	37	6	149847910	149847910	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:149847910C>A	ENST00000253329.2	-	8	713	c.681G>T	c.(679-681)gtG>gtT	p.V227V		NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	227					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		GTAGGTCTCCCACCTAAATTA	0.338000													8	12					1.12685e-05	1.30266e-05	0.307466	1	0
HECW1	23072	broad.mit.edu	37	7	43508580	43508580	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:43508580G>T	ENST00000395891.1	+	16	3580	c.2975G>T	c.(2974-2976)cGg>cTg	p.R992L	HECW1_ENST00000453890.1_Missense_Mutation_p.R958L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	992					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						AAAGTCCGACGGGATGCTCGC	0.557000													15	79					4.14922e-12	6.15838e-12	0.500413	1	0
CHRD	8646	broad.mit.edu	37	3	184105721	184105721	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:184105721G>T	ENST00000204604.1	+	20	2700	c.2454G>T	c.(2452-2454)ggG>ggT	p.G818G	CHRD_ENST00000348986.3_Silent_p.G778G|CHRD_ENST00000545352.1_Silent_p.G360G|CHRD_ENST00000450923.1_Silent_p.G818G|EIF2B5_ENST00000444495.1_Intron	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	818	VWFC 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCCTACAGGGGGGCACTGGAG	0.602000													9	18					0.00448238	0.0047419	0.307466	1	0
PROKR2	128674	broad.mit.edu	37	20	5294865	5294865	+	Missense_Mutation	SNP	C	C	T	rs144994507	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:5294865C>T	ENST00000546004.1	-	2	397	c.151G>A	c.(151-153)Gca>Aca	p.A51T	PROKR2_ENST00000217270.3_Missense_Mutation_p.A51T			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	51						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						ATCTTGGCTGCGAAGAAGGTC	0.512000										HNSCC(71;0.22)			21	117					0	0	0.654019	0	0
OR51D1	390038	broad.mit.edu	37	11	4661983	4661983	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4661983A>T	ENST00000357605.2	+	1	1039	c.963A>T	c.(961-963)caA>caT	p.Q321H		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTTCTCACAAGGTGGCAAGT	0.443000													20	42					0	0	0.639603	0	0
CRABP1	1381	broad.mit.edu	37	15	78635919	78635919	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:78635919T>A	ENST00000299529.6	+	3	433	c.328T>A	c.(328-330)Tgg>Agg	p.W110R		NM_004378.2	NP_004369.1	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	110					multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity			breast(1)|lung(4)|skin(1)	6					Alitretinoin(DB00523)|Etretinate(DB00926)	CAAAACCTACTGGACCCGTGA	0.547000													14	41					0	0	0.557998	0	0
NPTX2	4885	broad.mit.edu	37	7	98249110	98249110	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:98249110C>A	ENST00000265634.3	+	2	747	c.582C>A	c.(580-582)caC>caA	p.H194Q		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	194					synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CCTCGGCTCACCGGCAGAAGA	0.647000													6	54					0.00307968	0.00327455	0.278610	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76592507	76592507	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:76592507C>G	ENST00000307431.8	+	25	4236	c.3851C>G	c.(3850-3852)gCt>gGt	p.A1284G	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.A1236G|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.A1288G|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.A1212G|CNTNAP4_ENST00000469589.1_3'UTR|RP11-58C22.1_ENST00000563764.1_Intron	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1285					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GTAGACAGTGCTGAGGCTGTT	0.353000													3	20					0	0	0.115264	0	0
PAAF1	80227	broad.mit.edu	37	11	73589859	73589859	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:73589859C>T	ENST00000310571.3	+	2	136	c.83C>T	c.(82-84)cCc>cTc	p.P28L	PAAF1_ENST00000544552.1_5'UTR|PAAF1_ENST00000541951.1_5'UTR|PAAF1_ENST00000536003.1_5'UTR|PAAF1_ENST00000535604.1_5'UTR	NM_025155.2	NP_079431.1	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	28					interspecies interaction between organisms	proteasome complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					AGCTGTCATCCCCCAGGTAAT	0.438000													25	73					0	0	0.760397	0	0
TRPM1	4308	broad.mit.edu	37	15	31294125	31294125	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:31294125C>A	ENST00000542188.1	-	27	5142	c.4829G>T	c.(4828-4830)gGa>gTa	p.G1610V	TRPM1_ENST00000397795.2_Missense_Mutation_p.G1571V|TRPM1_ENST00000256552.6_Missense_Mutation_p.G1593V	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1571					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACTGGCATGTCCAGATCTGTC	0.403000													13	41					8.60227e-14	1.33466e-13	0.500413	1	0
DES	1674	broad.mit.edu	37	2	220286141	220286141	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:220286141C>A	ENST00000373960.3	+	6	1189	c.1103C>A	c.(1102-1104)gCg>gAg	p.A368E		NM_001927.3	NP_001918.3	P17661	DESM_HUMAN	desmin	368	Coil 2B.|Rod.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)	18		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GACAACATTGCGCGCCTGGAG	0.597000													20	30					3.51602e-12	5.24754e-12	0.575678	1	0
BAI2	576	broad.mit.edu	37	1	32203347	32203347	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:32203347G>T	ENST00000373658.3	-	19	3123	c.2782C>A	c.(2782-2784)Ctg>Atg	p.L928M	BAI2_ENST00000398556.3_Missense_Mutation_p.L876M|BAI2_ENST00000440175.2_Missense_Mutation_p.L570M|BAI2_ENST00000398542.1_Missense_Mutation_p.L861M|BAI2_ENST00000398538.1_Missense_Mutation_p.L916M|BAI2_ENST00000257070.4_Missense_Mutation_p.L928M|BAI2_ENST00000398547.1_Missense_Mutation_p.L861M|BAI2_ENST00000527361.1_Missense_Mutation_p.L928M|BAI2_ENST00000373655.2_Missense_Mutation_p.L928M	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	928					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GAGCCCGCCAGCTCCAGGGTC	0.642000													13	40					0.0105039	0.0109278	0.592651	1	0
ROBO1	6091	broad.mit.edu	37	3	78676697	78676697	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:78676697G>A	ENST00000436010.2	-	24	4529	c.3532C>T	c.(3532-3534)Ccc>Tcc	p.P1178S	ROBO1_ENST00000464233.1_Missense_Mutation_p.P1217S|ROBO1_ENST00000467549.1_Missense_Mutation_p.P1117S|ROBO1_ENST00000495273.1_Missense_Mutation_p.P1172S			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1217					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GGTGGCACGGGACATGGCATT	0.428000													5	15					0	0	0.248553	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735198	55735198	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55735198T>A	ENST00000312345.2	-	1	792	c.742A>T	c.(742-744)Atc>Ttc	p.I248F		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAATAAGTGATAGTACCTGCT	0.378000													8	27					0	0	0.387290	0	0
SLITRK5	26050	broad.mit.edu	37	13	88330388	88330388	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:88330388G>A	ENST00000325089.6	+	2	2964	c.2745G>A	c.(2743-2745)gtG>gtA	p.V915V	SLITRK5_ENST00000400028.3_Silent_p.V674V	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	915						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GGGAACCGGTGCTCTACAGCC	0.567000													23	76					0	0	0.667858	0	0
BARHL2	343472	broad.mit.edu	37	1	91182495	91182495	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:91182495G>A	ENST00000370445.4	-	1	299	c.258C>T	c.(256-258)caC>caT	p.H86H		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	86						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GGTGGAGGTGGTGATGATGCT	0.667000													6	17					0	0	0.217242	0	0
WDR33	55339	broad.mit.edu	37	2	128471188	128471188	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:128471188C>A	ENST00000322313.4	-	18	3435	c.3277G>T	c.(3277-3279)Gac>Tac	p.D1093Y		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1093					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AAACGTGGGTCCTCGGGATCC	0.612000													51	141					1.80625e-27	3.56328e-27	0.870114	1	0
CLNK	116449	broad.mit.edu	37	4	10492136	10492136	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:10492136G>T	ENST00000226951.6	-	19	1481	c.1242C>A	c.(1240-1242)caC>caA	p.H414Q	CLNK_ENST00000515667.1_Missense_Mutation_p.H152Q	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	414	SH2.				immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						GCTGAGTGAGGTGACACTGTT	0.428000													12	6					1.49906e-05	1.72026e-05	0.457914	1	0
KDM5B	10765	broad.mit.edu	37	1	202699083	202699083	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:202699083C>A	ENST00000367265.3	-	26	5413	c.4249G>T	c.(4249-4251)Gag>Tag	p.E1417*	KDM5B_ENST00000367264.2_Nonsense_Mutation_p.E1453*	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1417					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GAGAGGCCCTCTCTTTCCAGG	0.463000													23	40					2.89027e-11	4.15863e-11	0.624587	1	0
WDR49	151790	broad.mit.edu	37	3	167272471	167272471	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:167272471C>A	ENST00000453925.2	-	6	960	c.926G>T	c.(925-927)aGg>aTg	p.R309M	WDR49_ENST00000308378.3_Splice_Site_p.R256_splice|WDR49_ENST00000476376.1_Splice_Site_p.R81_splice|WDR49_ENST00000479765.1_Intron			Q8IV35	WDR49_HUMAN	WD repeat domain 49	255										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						ATAATCATACCTCTCCCAGCC	0.333000													27	65					1.88708e-17	3.19379e-17	0.729181	1	0
NOS1AP	9722	broad.mit.edu	37	1	162337011	162337011	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:162337011G>C	ENST00000493151.1	+	2	2757	c.390G>C	c.(388-390)ttG>ttC	p.L130F	NOS1AP_ENST00000530878.1_Missense_Mutation_p.L420F|NOS1AP_ENST00000361897.5_Missense_Mutation_p.L425F|NOS1AP_ENST00000454693.1_3'UTR|RP11-565P22.6_ENST00000431696.1_Intron	NM_001126060.1	NP_001119532.2	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	425	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCGACTGCTTGGTGAAGCTGG	0.682000													13	55					0	0	0.457914	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688796	26688796	+	Translation_Start_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:26688796C>A	ENST00000402979.1	+	0	580				SEZ6L_ENST00000248933.6_Silent_p.I173I|SEZ6L_ENST00000529632.2_Silent_p.I173I|SEZ6L_ENST00000403121.1_De_novo_Start_InFrame|SEZ6L_ENST00000360929.3_Silent_p.I173I|SEZ6L_ENST00000404234.3_Silent_p.I173I|SEZ6L_ENST00000343706.4_Silent_p.I173I			Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like							endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CGGACCCCATCGTGGCCTCCG	0.652000													58	48					1.84395e-34	3.82193e-34	0.870114	1	0
GNB3	2784	broad.mit.edu	37	12	6952162	6952162	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:6952162G>A	ENST00000229264.3	+	5	530	c.125G>A	c.(124-126)cGa>cAa	p.R42Q	GNB3_ENST00000435982.2_Missense_Mutation_p.R42Q	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	42					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						GTGGTGGGACGAGTCCAGATG	0.592000													16	22					0	0	0.557998	0	0
CACNA1A	773	broad.mit.edu	37	19	13409943	13409943	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:13409943G>T	ENST00000360228.5	-	19	2503	c.2504C>A	c.(2503-2505)aCc>aAc	p.T835N	CACNA1A_ENST00000573710.2_Missense_Mutation_p.T836N	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	836					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCTCTTGTTGGTGTTGTTGTT	0.687000													15	2					3.52763e-06	4.165e-06	0.520397	1	0
ARHGAP30	257106	broad.mit.edu	37	1	161023116	161023116	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161023116A>C	ENST00000368013.3	-	6	916	c.596T>G	c.(595-597)gTa>gGa	p.V199G	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.V199G|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.V22G	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	199	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GATGGATTGTACCCGCACCTC	0.567000													16	76					0	0	0.539581	0	0
LEMD2	221496	broad.mit.edu	37	6	33756206	33756206	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:33756206A>C	ENST00000293760.5	-	1	707	c.688T>G	c.(688-690)Tgg>Ggg	p.W230G		NM_181336.3	NP_851853.1	Q8NC56	LEMD2_HUMAN	LEM domain containing 2	230						integral to nuclear inner membrane				central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)|pancreas(1)	9						ATCTTCACCCAAAGGATGCCC	0.716000													4	12					0	0	0.184627	0	0
BRINP2	57795	broad.mit.edu	37	1	177249822	177249822	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:177249822G>T	ENST00000361539.4	+	8	1822	c.1510G>T	c.(1510-1512)Ggg>Tgg	p.G504W	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		504						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AAACTTTCTTGGGCTGGAGAC	0.577000													5	69					0.0293803	0.0301822	0.248553	1	0
FMR1NB	158521	broad.mit.edu	37	X	147062985	147062985	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:147062985G>T	ENST00000370467.3	+	1	137	c.63G>T	c.(61-63)gtG>gtT	p.V21V		NM_152578.2	NP_689791.1	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	21						integral to membrane				breast(2)|cervix(1)|endometrium(3)|large_intestine(7)|lung(10)|ovary(1)|skin(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CCATGCGTGTGGCTCACTTAG	0.597000													13	70					9.31168e-06	1.08377e-05	0.435327	1	0
AMOT	154796	broad.mit.edu	37	X	112022736	112022736	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:112022736A>T	ENST00000371959.3	-	10	2645	c.2646T>A	c.(2644-2646)tcT>tcA	p.S882S	AMOT_ENST00000371962.1_Silent_p.S650S|AMOT_ENST00000304758.1_Silent_p.S473S|AMOT_ENST00000524145.1_Silent_p.S882S	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	882					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gagcaggaacagagatgggag	0.592000													3	22					0	0	0.115264	0	0
MMP9	4318	broad.mit.edu	37	20	44640873	44640873	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:44640873C>A	ENST00000372330.3	+	7	1114	c.1095C>A	c.(1093-1095)ggC>ggA	p.G365G		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	365	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CCAGCGAGGGCCGCGGAGATG	0.647000													29	84					2.80507e-11	4.05153e-11	0.760397	1	0
MARK4	57787	broad.mit.edu	37	19	45781216	45781216	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:45781216G>T	ENST00000300843.4	+	9	1119	c.822G>T	c.(820-822)cgG>cgT	p.R274R	MARK4_ENST00000262891.4_Silent_p.R274R	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	274	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGAAGTACCGGGTCCCTTTCT	0.582000													113	60					1.16149e-67	2.62416e-67	0.870114	1	0
COL23A1	91522	broad.mit.edu	37	5	177683396	177683396	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:177683396C>T	ENST00000390654.3	-	15	1197	c.840G>A	c.(838-840)ggG>ggA	p.G280G	COL23A1_ENST00000407622.1_Silent_p.G244G	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	280	Collagen-like 2.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		GGCCAGGCTCCCCCTGTGGAG	0.662000													14	11					0	0	0.624587	0	0
APCS	325	broad.mit.edu	37	1	159558220	159558220	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:159558220C>A	ENST00000255040.2	+	2	491	c.394C>A	c.(394-396)Cct>Act	p.P132T		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	132	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					CAATGGGACACCTTTGGTGAA	0.483000													20	54					1.10923e-09	1.5051e-09	0.639603	1	0
OR5W2	390148	broad.mit.edu	37	11	55681287	55681287	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55681287T>A	ENST00000344514.1	-	1	771	c.772A>T	c.(772-774)Atg>Ttg	p.M258L		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M258L(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CGGAAATACATAAAGAGCAGA	0.438000													19	42					0	0	0.608945	0	0
GPR142	350383	broad.mit.edu	37	17	72368040	72368040	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:72368040G>T	ENST00000335666.4	+	4	738	c.690G>T	c.(688-690)gtG>gtT	p.V230V		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	230						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CCCAGGCTGTGGTGCGCACGG	0.647000													15	25					4.7546e-09	6.31933e-09	0.500413	1	0
SLC12A7	10723	broad.mit.edu	37	5	1083932	1083932	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:1083932C>G	ENST00000264930.5	-	8	1100	c.1057G>C	c.(1057-1059)Gac>Cac	p.D353H		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	353					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	AAGTACTCGTCACAGGCGGCG	0.642000													19	189					0	0	0.608945	0	0
GPC5	2262	broad.mit.edu	37	13	92380883	92380883	+	Missense_Mutation	SNP	C	C	A	rs140775585		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:92380883C>A	ENST00000377067.3	+	4	1490	c.1118C>A	c.(1117-1119)aCa>aAa	p.T373K	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	373						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AAGACCACCACAAGGAACAGT	0.408000													26	115					2.20262e-25	4.25162e-25	0.769981	1	0
SCAF8	22828	broad.mit.edu	37	6	155123231	155123231	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:155123231G>T	ENST00000367178.3	+	7	1309	c.733G>T	c.(733-735)Gca>Tca	p.A245S	SCAF8_ENST00000367186.4_Missense_Mutation_p.A311S|SCAF8_ENST00000417268.1_Missense_Mutation_p.A245S	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	245	Gln-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						AGCTGCAGCTGCAGCTGCCAA	0.423000													8	26					1.33987e-11	1.95476e-11	0.361761	1	0
CCDC180	100499483	broad.mit.edu	37	9	100124675	100124675	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:100124675A>T	ENST00000375202.2	+	42	5338	c.3986A>T	c.(3985-3987)aAc>aTc	p.N1329I	CCDC180_ENST00000357054.1_Missense_Mutation_p.N1263I|CCDC180_ENST00000395220.1_3'UTR|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000529487.1_Missense_Mutation_p.N1329I					coiled-coil domain containing 180																		CAGCCAGAAAACTCTGGGAAG	0.612000													58	109					0	0	0.870114	0	0
HMCN1	83872	broad.mit.edu	37	1	186084071	186084071	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:186084071G>T	ENST00000271588.4	+	74	11626	c.11397G>T	c.(11395-11397)caG>caT	p.Q3799H	HMCN1_ENST00000367492.2_Missense_Mutation_p.Q3799H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3799					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TAGATTTACAGGTCCATGGTA	0.423000													16	194					5.26018e-13	7.99649e-13	0.608945	1	0
DOPEY1	23033	broad.mit.edu	37	6	83851639	83851639	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:83851639G>C	ENST00000349129.2	+	24	5675		c.e24-1		DOPEY1_ENST00000484282.1_Splice_Site|DOPEY1_ENST00000237163.5_Splice_Site|DOPEY1_ENST00000369739.3_Splice_Site	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1						protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AATTGTTTTAGAACTTGAGAC	0.318000													7	26					0	0	0.278610	0	0
ASAP2	8853	broad.mit.edu	37	2	9528612	9528612	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:9528612G>T	ENST00000281419.3	+	22	2660	c.2320G>T	c.(2320-2322)Gcc>Tcc	p.A774S	ASAP2_ENST00000491413.1_3'UTR|ASAP2_ENST00000315273.4_Missense_Mutation_p.A774S	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	774	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						CCCACCTCCCGCCCAGCCTGC	0.587000													5	34					0.000602214	0.000654747	0.184627	1	0
CD244	51744	broad.mit.edu	37	1	160808825	160808825	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:160808825G>C	ENST00000368034.4	-	4	847	c.670C>G	c.(670-672)Ccg>Gcg	p.P224A	CD244_ENST00000368033.3_Missense_Mutation_p.P229A|CD244_ENST00000368032.2_Missense_Mutation_p.P224A|CD244_ENST00000481677.1_5'UTR|CD244_ENST00000322302.7_Missense_Mutation_p.P132A	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	229					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCAAAAACGGCCAAAATCTG	0.522000													10	71					0	0	0.411799	0	0
KIAA1210	57481	broad.mit.edu	37	X	118239097	118239097	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:118239097C>T	ENST00000402510.2	-	7	925	c.926G>A	c.(925-927)cGc>cAc	p.R309H		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	309										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TCGGCGTCGGCGCGATGGTGG	0.413000													24	119					0	0	0.760397	0	0
ADCY5	111	broad.mit.edu	37	3	123009977	123009977	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:123009977T>A	ENST00000462833.1	-	18	4522	c.3310A>T	c.(3310-3312)Atc>Ttc	p.I1104F	ADCY5_ENST00000491190.1_Missense_Mutation_p.I762F|ADCY5_ENST00000309879.5_Missense_Mutation_p.I754F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1104	Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		AAGTCAGCGATGATCTCATTG	0.592000													16	14					0	0	0.608945	0	0
SLC30A10	55532	broad.mit.edu	37	1	220089008	220089008	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:220089008C>A	ENST00000366926.3	-	4	1402	c.1241G>T	c.(1240-1242)tGt>tTt	p.C414F	SLC30A10_ENST00000536446.1_Missense_Mutation_p.C169F|SLC30A10_ENST00000484079.1_5'UTR	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	414					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GGGGGGACAACACAGCTGCTT	0.552000													11	72					3.86212e-05	4.36547e-05	0.361761	1	0
SRRM1	10250	broad.mit.edu	37	1	24995874	24995874	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:24995874G>T	ENST00000323848.9	+	14	2315	c.2000G>T	c.(1999-2001)aGc>aTc	p.S667I	SRRM1_ENST00000447431.2_Missense_Mutation_p.S679I|SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000374389.4_Missense_Mutation_p.S676I	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	667	Arg-rich.|Necessary for speckles and matrix localization.|Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TCTTCCCCAAGCCGCTCTACC	0.572000													20	19					0.000295444	0.000324781	0.624587	1	0
SERPINA6	866	broad.mit.edu	37	14	94780496	94780496	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:94780496C>A	ENST00000341584.3	-	2	636	c.490G>T	c.(490-492)Gca>Tca	p.A164S		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	164					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CTGGCTGTTGCCCAGTCCTGG	0.488000													66	74					9.35569e-46	2.05694e-45	0.870114	1	0
SAMD9	54809	broad.mit.edu	37	7	92733475	92733475	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:92733475C>T	ENST00000379958.2	-	3	2205	c.1936G>A	c.(1936-1938)Gaa>Aaa	p.E646K		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	646						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ATGATATCTTCTTCCTTTTTC	0.348000													13	69					0	0	0.500413	0	0
AXIN1	8312	broad.mit.edu	37	16	354413	354413	+	Missense_Mutation	SNP	C	C	A	rs150141520		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:354413C>A	ENST00000262320.3	-	5	1516	c.1145G>T	c.(1144-1146)cGc>cTc	p.R382L	AXIN1_ENST00000481769.1_5'UTR|AXIN1_ENST00000354866.3_Missense_Mutation_p.R382L	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	382	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				AGGCTCCACGCGGACCTCCTT	0.637000													23	23					6.38683e-12	9.45713e-12	0.729181	1	0
TNFSF11	8600	broad.mit.edu	37	13	43180710	43180710	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:43180710G>T	ENST00000398795.2	+	5	759	c.391G>T	c.(391-393)Gga>Tga	p.G131*	TNFSF11_ENST00000544862.1_Nonsense_Mutation_p.G131*|TNFSF11_ENST00000358545.2_Nonsense_Mutation_p.G131*|TNFSF11_ENST00000239849.6_Nonsense_Mutation_p.G204*|TNFSF11_ENST00000405262.2_Nonsense_Mutation_p.G131*	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	204					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTTTAGCAATGGAAAACTAAT	0.423000													24	49					2.32416e-17	3.92998e-17	0.624587	1	0
COL11A2	1302	broad.mit.edu	37	6	33154373	33154373	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:33154373C>A	ENST00000395194.1	-	5	1042	c.829G>T	c.(829-831)Gca>Tca	p.A277S	COL11A2_ENST00000374708.4_Intron|COL11A2_ENST00000395197.1_Intron|COL11A2_ENST00000374712.1_Intron|COL11A2_ENST00000341947.2_Intron|COL11A2_ENST00000357486.1_Intron|COL11A2_ENST00000374714.1_Intron|COL11A2_ENST00000374713.1_Intron|COL11A2_ENST00000361917.1_Intron	NM_001163771.1	NP_001157243.1	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1213	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CTGGGGTGTGCTGCACTTGGG	0.577000													15	61					4.75885e-15	7.60285e-15	0.520397	1	0
LRRC26	389816	broad.mit.edu	37	9	140063358	140063358	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:140063358C>A	ENST00000371542.3	-	2	1060	c.953G>T	c.(952-954)gGc>gTc	p.G318V	RP11-350O14.18_ENST00000568665.1_RNA	NM_001013653.2	NP_001013675.1	Q2I0M4	LRC26_HUMAN	leucine rich repeat containing 26	318						cytoplasm|cytoskeleton|voltage-gated potassium channel complex	ion channel activity|potassium channel regulator activity|protein binding					all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CGAGGCACAGCCGTGGGGGTC	0.796000													7	9					1.61879e-10	2.27695e-10	0.411799	1	0
TRBC2	28638	broad.mit.edu	37	7	142499050	142499050	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142499050G>T	ENST00000466254.1	+	0	326																											ATGACGAGTGGACCCAGGATA	0.627000													27	157					2.09667e-21	3.86098e-21	0.788014	1	0
NDN	4692	broad.mit.edu	37	15	23932360	23932360	+	Nonsense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:23932360G>C	ENST00000331837.4	-	1	90	c.5C>G	c.(4-6)tCa>tGa	p.S2*		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	2					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		ACTTTGTTCTGACATGTCTGC	0.637000									Prader-Willi syndrome				18	20					0	0	0.575678	0	0
STAB2	55576	broad.mit.edu	37	12	104063375	104063375	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:104063375C>A	ENST00000388887.2	+	21	2433	c.2229C>A	c.(2227-2229)ggC>ggA	p.G743G		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	743	EGF-like 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTCCAGGAGGCTTCTCAAATC	0.423000													28	71					9.45814e-24	1.80164e-23	0.804634	1	0
DHTKD1	55526	broad.mit.edu	37	10	12131144	12131144	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:12131144G>T	ENST00000263035.4	+	5	939	c.877G>T	c.(877-879)Gtc>Ttc	p.V293F	DHTKD1_ENST00000465617.1_Intron	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	293					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CCTGGAGGCCGTCAACCCCGT	0.622000													15	132					3.45872e-05	3.94026e-05	0.500413	1	0
SLC24A4	123041	broad.mit.edu	37	14	92958090	92958090	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:92958090T>A	ENST00000532405.1	+	15	1845	c.1619T>A	c.(1618-1620)cTg>cAg	p.L540Q	SLC24A4_ENST00000531433.1_Missense_Mutation_p.L521Q|SLC24A4_ENST00000393265.2_Missense_Mutation_p.L476Q|SLC24A4_ENST00000351924.5_Missense_Mutation_p.L504Q|SLC24A4_ENST00000298877.1_Missense_Mutation_p.L523Q			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	540						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCGTGGGGCCTGCAGACCATG	0.512000													38	92					0	0	0.870114	0	0
BCHE	590	broad.mit.edu	37	3	165548127	165548127	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:165548127A>C	ENST00000264381.3	-	2	861	c.695T>G	c.(694-696)gTt>gGt	p.V232G	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	232					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding	p.V232G(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ATGCAGGCTAACTGAAGCTGC	0.438000													37	48					0	0	0.819951	0	0
FABP9	646480	broad.mit.edu	37	8	82373696	82373696	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:82373696C>A	ENST00000379071.2	-	1	118	c.63G>T	c.(61-63)atG>atT	p.M21I	RP11-157I4.4_ENST00000524085.2_RNA	NM_001080526.1	NP_001073995.1	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	21							lipid binding|transporter activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6			Epithelial(68;0.186)			CCAGTTCTTTCATGTAATCCT	0.393000													20	171					2.44723e-14	3.85091e-14	0.681144	1	0
NAV3	89795	broad.mit.edu	37	12	78604278	78604278	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:78604278C>A	ENST00000397909.2	+	40	7312	c.7139C>A	c.(7138-7140)tCt>tAt	p.S2380Y	NAV3_ENST00000228327.6_Missense_Mutation_p.S2358Y|NAV3_ENST00000541270.1_Missense_Mutation_p.S210Y|NAV3_ENST00000266692.7_Missense_Mutation_p.S2181Y|NAV3_ENST00000536525.2_Missense_Mutation_p.S2358Y			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2380						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTGGATTCATCTCTTGAATCT	0.388000										HNSCC(70;0.22)			10	18					9.70103e-10	1.32204e-09	0.361761	1	0
ATP2A3	489	broad.mit.edu	37	17	3856723	3856723	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:3856723C>G	ENST00000309890.7	-	3	287	c.136_splice	c.e3-1	p.G46_splice	ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397035.3_Splice_Site_p.G46_splice|ATP2A3_ENST00000397041.3_Splice_Site_p.G46_splice|ATP2A3_ENST00000397043.3_Splice_Site_p.G46_splice|ATP2A3_ENST00000352011.3_Splice_Site_p.G46_splice|ATP2A3_ENST00000359983.3_Splice_Site_p.G46_splice	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	46					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CAGGGACTTCCCTGGGAACGG	0.652000													14	48					0	0	0.500413	0	0
OR5D13	390142	broad.mit.edu	37	11	55541293	55541293	+	Missense_Mutation	SNP	C	C	A	rs149270836	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55541293C>A	ENST00000361760.1	+	1	380	c.380C>A	c.(379-381)gCa>gAa	p.A127E		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				CGTTTTGTGGCAGTTTGTAAA	0.438000													22	204					1.64293e-13	2.53443e-13	0.654019	1	0
FCGBP	8857	broad.mit.edu	37	19	40433141	40433141	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:40433141T>A	ENST00000221347.6	-	2	1135	c.1128A>T	c.(1126-1128)gcA>gcT	p.A376A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	376	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCCCCCACTGCATGCCCAT	0.617000													47	28					0	0	0.870114	0	0
XIRP2	129446	broad.mit.edu	37	2	168104332	168104332	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:168104332C>T	ENST00000409195.1	+	9	6519	c.6430C>T	c.(6430-6432)Cct>Tct	p.P2144S	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.P1922S|XIRP2_ENST00000295237.9_Missense_Mutation_p.P2144S|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1969	Pro-rich.				actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TATAAAGAGTCCTAAAAAGAC	0.403000													13	19					0	0	0.435327	0	0
PKM	5315	broad.mit.edu	37	15	72511302	72511302	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:72511302C>A	ENST00000319622.6	-	2	593	c.137G>T	c.(136-138)gGc>gTc	p.G46V	PKM_ENST00000565184.1_Missense_Mutation_p.G46V|PKM_ENST00000389093.3_Missense_Mutation_p.G46V|PKM_ENST00000568883.1_Intron|PKM_ENST00000335181.5_Missense_Mutation_p.G46V|PKM_ENST00000449901.2_Missense_Mutation_p.A62S|PKM_ENST00000568459.1_Missense_Mutation_p.G46V|PKM_ENST00000565154.1_Missense_Mutation_p.G46V	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						ACAGATGATGCCAGTGTTCCG	0.532000													22	28					2.44723e-14	3.85091e-14	0.681144	1	0
TENM1	10178	broad.mit.edu	37	X	123514663	123514663	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123514663C>A	ENST00000422452.2	-	32	7985	c.7922G>T	c.(7921-7923)cGg>cTg	p.R2641L	TENM1_ENST00000371130.3_Missense_Mutation_p.R2634L|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.R2636L(1)									TGTCCCATACCGGATGTTGAA	0.517000													11	57					2.27111e-07	2.82127e-07	0.411799	1	0
LPHN2	23266	broad.mit.edu	37	1	82408774	82408774	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:82408774G>T	ENST00000370728.1	+	8	1164	c.519G>T	c.(517-519)atG>atT	p.M173I	LPHN2_ENST00000370730.1_Missense_Mutation_p.M173I|LPHN2_ENST00000370723.1_Missense_Mutation_p.M173I|LPHN2_ENST00000359929.3_Missense_Mutation_p.M173I|LPHN2_ENST00000319517.6_Missense_Mutation_p.M173I|LPHN2_ENST00000370715.1_Missense_Mutation_p.M173I|LPHN2_ENST00000370727.1_Missense_Mutation_p.M173I|LPHN2_ENST00000370721.1_Missense_Mutation_p.M177I|LPHN2_ENST00000370713.1_Missense_Mutation_p.M173I|LPHN2_ENST00000271029.4_Missense_Mutation_p.M173I|LPHN2_ENST00000394879.1_Missense_Mutation_p.M173I|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370717.2_Missense_Mutation_p.M173I|LPHN2_ENST00000335786.5_Missense_Mutation_p.M173I|LPHN2_ENST00000370725.1_Missense_Mutation_p.M173I			O95490	LPHN2_HUMAN	latrophilin 2	173	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTTATTTCATGCCCTGGACTC	0.398000													18	32					1.02788e-11	1.5066e-11	0.520397	1	0
KCNB2	9312	broad.mit.edu	37	8	73848809	73848809	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:73848809C>A	ENST00000523207.1	+	3	1807	c.1219C>A	c.(1219-1221)Ctg>Atg	p.L407M		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	407					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TGCTGGGGTTCTGGTTATTGC	0.443000													26	81					4.74835e-14	7.4161e-14	0.750413	1	0
ZNF208	7757	broad.mit.edu	37	19	22154549	22154549	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22154549C>A	ENST00000397126.4	-	4	3435	c.3287G>T	c.(3286-3288)tGg>tTg	p.W1096L	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTTTGAGGACCAGTTGAAAGC	0.428000													12	63					5.50884e-06	6.43952e-06	0.411799	1	0
KCNJ5	3762	broad.mit.edu	37	11	128786482	128786482	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:128786482G>C	ENST00000529694.1	+	3	1492	c.1116G>C	c.(1114-1116)agG>agC	p.R372S	KCNJ5_ENST00000338350.4_Missense_Mutation_p.R372S|KCNJ5_ENST00000533599.1_Missense_Mutation_p.R372S	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	372					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	AAATGAAGAGGGAAGGCCGGC	0.577000													23	68					0	0	0.639603	0	0
MYCBP2	23077	broad.mit.edu	37	13	77655991	77655991	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:77655991C>A	ENST00000407578.2	-	64	11440	c.11174G>T	c.(11173-11175)gGc>gTc	p.G3725V	MYCBP2_ENST00000544440.2_Missense_Mutation_p.G3687V|MYCBP2_ENST00000357337.6_Missense_Mutation_p.G3687V|MYCBP2-AS1_ENST00000450627.2_RNA|MYCBP2-AS1_ENST00000422231.2_RNA|MYCBP2-AS1_ENST00000448470.2_RNA|MYCBP2-AS1_ENST00000593933.1_RNA	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3687	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCTTCAAAGCCAGACTGTAT	0.353000													25	243					1.55811e-20	2.82229e-20	0.729181	1	0
SLC5A11	115584	broad.mit.edu	37	16	24881295	24881295	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:24881295C>A	ENST00000347898.3	+	4	903	c.281C>A	c.(280-282)aCg>aAg	p.T94K	SLC5A11_ENST00000567758.1_Missense_Mutation_p.T94K|SLC5A11_ENST00000539472.1_Missense_Mutation_p.T30K|SLC5A11_ENST00000424767.2_Missense_Mutation_p.T94K|SLC5A11_ENST00000568579.1_Intron|SLC5A11_ENST00000545376.1_Intron|SLC5A11_ENST00000449109.2_Missense_Mutation_p.T30K|SLC5A11_ENST00000569071.1_Missense_Mutation_p.T30K|SLC5A11_ENST00000565769.1_Missense_Mutation_p.T30K	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	94					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		GGTGCTGCTACGGGCATTTCT	0.473000													27	46					9.80776e-20	1.75292e-19	0.706142	1	0
GRXCR2	643226	broad.mit.edu	37	5	145239474	145239474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:145239474C>A	ENST00000377976.1	-	3	568	c.569G>T	c.(568-570)gGg>gTg	p.G190V		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	190										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						GGGAATATCCCCTTCCTGCAA	0.532000													18	5					1.2644e-06	1.52948e-06	0.592651	1	0
MAP2K3	5606	broad.mit.edu	37	17	21217477	21217477	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:21217477T>A	ENST00000342679.4	+	12	1228	c.979T>A	c.(979-981)Ttg>Atg	p.L327M	MAP2K3_ENST00000316920.6_Missense_Mutation_p.L298M|MAP2K3_ENST00000361818.5_Missense_Mutation_p.L298M	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	327					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CTTCTTCACCTTGCACAAAAC	0.617000													161	389					0	0	0.870114	0	0
SLC25A41	284427	broad.mit.edu	37	19	6432093	6432093	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:6432093C>A	ENST00000321510.6	-	2	398	c.330G>T	c.(328-330)acG>acT	p.T110T		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	110					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						CCAGAGGTGCCGTGCCCGTGC	0.617000													27	54					2.65835e-16	4.37708e-16	0.717897	1	0
DACH1	1602	broad.mit.edu	37	13	72255957	72255957	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:72255957G>T	ENST00000305425.4	-	2	1362	c.940C>A	c.(940-942)Ctc>Atc	p.L314I	DACH1_ENST00000354591.4_Missense_Mutation_p.L314I|DACH1_ENST00000359684.2_Missense_Mutation_p.L314I|DACH1_ENST00000313174.7_Missense_Mutation_p.L314I	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	312	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GGAGACATGAGACCAGGGACA	0.428000													13	59					0.000958276	0.00103648	0.557998	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889700	18889700	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:18889700C>A	ENST00000380548.4	+	25	4936	c.4597C>A	c.(4597-4599)Cct>Act	p.P1533T	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.P234T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1533						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GAAGGTTCGCCCTGCGGTGCA	0.667000													6	26					1.06961e-07	1.35101e-07	0.278610	1	0
GPR132	29933	broad.mit.edu	37	14	105518004	105518004	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:105518004C>T	ENST00000329797.3	-	4	1381	c.470G>A	c.(469-471)aGg>aAg	p.R157K	GPR132_ENST00000539291.2_Missense_Mutation_p.R157K|GPR132_ENST00000392585.2_Missense_Mutation_p.R148K|GPR132_ENST00000546679.1_5'UTR	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	157	Poly-Arg.				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GATGGCGGTCCTCCGGCGGCG	0.617000													26	61					0	0	0.729181	0	0
RETSAT	54884	broad.mit.edu	37	2	85581606	85581606	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:85581606G>A	ENST00000295802.4	-	1	137	c.25C>T	c.(25-27)Ctg>Ttg	p.L9L	RETSAT_ENST00000263854.6_Silent_p.L9L|RETSAT_ENST00000457495.2_Silent_p.L9L	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	9					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	AGCACAGCCAGGAGCAGCACC	0.627000													43	110					0	0	0.870114	0	0
LRP1B	53353	broad.mit.edu	37	2	141200193	141200193	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:141200193C>A	ENST00000389484.3	-	66	11266		c.e66-1			NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGTTTTCAGCTTAGAAAGAA	0.358000										TSP Lung(27;0.18)			26	17					6.00712e-18	1.03246e-17	0.760397	1	0
ZNF335	63925	broad.mit.edu	37	20	44586501	44586501	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:44586501C>A	ENST00000322927.2	-	16	2420	c.2320G>T	c.(2320-2322)Ggc>Tgc	p.G774C	ZNF335_ENST00000426788.1_Missense_Mutation_p.G619C	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GTGGCGCCGCCCAGGGTGTCA	0.592000													31	80					4.32679e-17	7.27705e-17	0.827153	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577045	33577045	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:33577045G>T	ENST00000504830.1	-	19	3421	c.3086C>A	c.(3085-3087)cCc>cAc	p.P1029H	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P944H	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1029	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAGCATTCTGGGCCTGGATGT	0.532000										HNSCC(64;0.19)			14	101					4.36969e-10	6.038e-10	0.435327	1	0
GALNT15	117248	broad.mit.edu	37	3	16217079	16217079	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:16217079G>T	ENST00000339732.5	+	1	924	c.421G>T	c.(421-423)Ggg>Tgg	p.G141W	GALNT15_ENST00000437509.1_Missense_Mutation_p.G141W|GALNT15_ENST00000470031.1_3'UTR	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		TGATGAGGACGGGGAGGTGTC	0.647000													5	12					0.0293803	0.0301822	0.248553	1	0
RAB10	10890	broad.mit.edu	37	2	26257601	26257601	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:26257601A>T	ENST00000264710.4	+	1	623	c.124A>T	c.(124-126)Ata>Tta	p.I42L		NM_016131.4	NP_057215.3	P61026	RAB10_HUMAN	RAB10, member RAS oncogene family	42					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATTTCCACCATAGGTAAGAC	0.478000													26	162					0	0	0.796494	0	0
SF3B1	23451	broad.mit.edu	37	2	198281514	198281514	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:198281514T>C	ENST00000335508.5	-	6	708	c.617A>G	c.(616-618)cAg>cGg	p.Q206R		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	206					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ACCAGGAGTCTGATCAGCTGT	0.408000			Mis		myelodysplastic syndrome								75	123					0	0	0.870114	0	0
TRPS1	7227	broad.mit.edu	37	8	116616856	116616856	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:116616856T>C	ENST00000395715.3	-	4	1917	c.1340A>G	c.(1339-1341)tAc>tGc	p.Y447C	TRPS1_ENST00000519674.1_Missense_Mutation_p.Y434C|TRPS1_ENST00000520276.1_Missense_Mutation_p.Y438C|TRPS1_ENST00000220888.5_Missense_Mutation_p.Y434C|TRPS1_ENST00000519076.1_Intron	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	434					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTACACCAGTAGTAACTGGT	0.473000									Langer-Giedion syndrome				3	37					0	0	0.150653	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107209	27107209	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:27107209G>T	ENST00000354348.2	+	1	134	c.122G>T	c.(121-123)cGc>cTc	p.R41L	HIST1H2BK_ENST00000396891.4_Intron	NM_003495.2	NP_003486.1	P62805	H4_HUMAN	histone cluster 1, H4i	41					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CTTGCTCGCCGCGGCGGCGTG	0.637000			T	BCL6	NHL								11	36					2.61681e-11	3.78252e-11	0.457914	1	0
RPAP1	26015	broad.mit.edu	37	15	41819196	41819196	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:41819196C>A	ENST00000304330.4	-	14	1933	c.1817G>T	c.(1816-1818)gGg>gTg	p.G606V	RPAP1_ENST00000561603.1_Missense_Mutation_p.G606V	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	606						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGGCCCTGCCCCCACAGGAGA	0.552000													61	35					9.65139e-37	2.0386e-36	0.870114	1	0
CPA3	1359	broad.mit.edu	37	3	148596478	148596478	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:148596478G>T	ENST00000296046.3	+	5	469	c.417G>T	c.(415-417)atG>atT	p.M139I	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	139					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			ATCCTGAAATGGTCTCTCGTA	0.294000													24	143					5.45727e-16	8.93094e-16	0.729181	1	0
AGAP11	119385	broad.mit.edu	37	10	88768781	88768781	+	RNA	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:88768781A>G	ENST00000444431.1	+	0	3381				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AAGCACCAACAACTTAAAAGA	0.493000													4	18					0	0	0.184627	0	0
TIAM2	26230	broad.mit.edu	37	6	155485672	155485672	+	Missense_Mutation	SNP	C	C	A	rs144207308		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:155485672C>A	ENST00000461783.3	+	10	3425	c.2152C>A	c.(2152-2154)Cgc>Agc	p.R718S	TIAM2_ENST00000456144.1_Missense_Mutation_p.R718S|TIAM2_ENST00000318981.5_Missense_Mutation_p.R718S|TIAM2_ENST00000367174.2_Missense_Mutation_p.R70S|TIAM2_ENST00000456877.2_Missense_Mutation_p.R30S|TIAM2_ENST00000529824.2_Missense_Mutation_p.R718S|TIAM2_ENST00000528391.2_Missense_Mutation_p.R30S|TIAM2_ENST00000360366.4_Missense_Mutation_p.R718S			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	718					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGCCGCCAGCCGCCCCTCCAA	0.562000													78	51					1.45819e-31	2.97326e-31	0.870114	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319631	21319631	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:21319631G>T	ENST00000583088.1	+	3	1872	c.977G>T	c.(976-978)cGc>cTc	p.R326L	KCNJ12_ENST00000331718.5_Missense_Mutation_p.R326L	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.R326L(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		TGGGGTCACCGCTTTGAGCCC	0.587000										Prostate(3;0.18)			10	200					0.00621372	0.00653308	0.335167	1	0
PCDHB8	56128	broad.mit.edu	37	5	140559855	140559855	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140559855C>T	ENST00000239444.2	+	1	2485	c.2240C>T	c.(2239-2241)tCt>tTt	p.S747F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		747					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGAGCCTGTCTCAGAACTAT	0.582000													42	30					0	0	0.870114	0	0
RLIM	51132	broad.mit.edu	37	X	73812086	73812086	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:73812086G>T	ENST00000332687.6	-	4	1282	c.1064C>A	c.(1063-1065)aCc>aAc	p.T355N	RLIM_ENST00000349225.2_Missense_Mutation_p.T355N	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	355					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACTTTCATAGGTGACAGTGTT	0.468000													8	33					9.70103e-10	1.32204e-09	0.361761	1	0
GSR	2936	broad.mit.edu	37	8	30537129	30537129	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:30537129C>G	ENST00000221130.5	-	13	1567	c.1477G>C	c.(1477-1479)Gtt>Ctt	p.V493L	GSR_ENST00000546342.1_Missense_Mutation_p.V464L|GSR_ENST00000537535.1_Missense_Mutation_p.V411L|GSR_ENST00000414019.1_Missense_Mutation_p.V450L|GSR_ENST00000541648.1_Missense_Mutation_p.V440L	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	493					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TTCACTGCAACAGCAAAACCC	0.463000													23	28					0	0	0.667858	0	0
PCDH18	54510	broad.mit.edu	37	4	138450964	138450964	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:138450964G>T	ENST00000344876.4	-	1	2665	c.2279C>A	c.(2278-2280)aCa>aAa	p.T760K	PCDH18_ENST00000507846.1_Missense_Mutation_p.T540K|PCDH18_ENST00000412923.2_Missense_Mutation_p.T760K|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	760					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AGGCACCAATGTGATGTCCCC	0.507000													14	42					5.3912e-06	6.33744e-06	0.539581	1	0
CALCR	799	broad.mit.edu	37	7	93055889	93055889	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:93055889C>A	ENST00000359558.2	-	16	1605	c.1306G>T	c.(1306-1308)Gtg>Ttg	p.V436L	CALCR_ENST00000426151.1_Missense_Mutation_p.V402L|CALCR_ENST00000394441.1_Missense_Mutation_p.V402L|CALCR_ENST00000360249.4_Missense_Mutation_p.V418L|CALCR_ENST00000421592.1_Missense_Mutation_p.V418L	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	418					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGGCGCTTCACGGTGGTTTGG	0.527000													15	26					3.45872e-05	3.94026e-05	0.500413	1	0
GPR98	84059	broad.mit.edu	37	5	89923460	89923460	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:89923460G>T	ENST00000405460.2	+	7	1201	c.1105G>T	c.(1105-1107)Gga>Tga	p.G369*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	369					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TACCTTACAGGGAGATGCTGT	0.353000													43	33					1.07234e-20	1.95179e-20	0.870114	1	0
DMBT1	1755	broad.mit.edu	37	10	124377706	124377706	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:124377706G>T	ENST00000338354.3	+	38	4784	c.4678G>T	c.(4678-4680)Gga>Tga	p.G1560*	DMBT1_ENST00000330163.4_Nonsense_Mutation_p.G932*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.G932*|DMBT1_ENST00000344338.3_Nonsense_Mutation_p.G1550*|DMBT1_ENST00000359586.6_Nonsense_Mutation_p.G411*|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.G1550*|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.G1560*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1560	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTCAGCCCCAGGAAATGCCCA	0.612000													44	243					5.48756e-27	1.07916e-26	0.859065	1	0
ATP2A2	488	broad.mit.edu	37	12	110777348	110777348	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:110777348G>C	ENST00000395494.2	+	12	2065	c.1502G>C	c.(1501-1503)cGa>cCa	p.R501P	ATP2A2_ENST00000308664.6_Missense_Mutation_p.R528P|ATP2A2_ENST00000539276.2_Missense_Mutation_p.R528P			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	528					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						ACCCACATTCGAGTTGGAAGT	0.458000													3	45					0	0	0.115264	0	0
KCNH8	131096	broad.mit.edu	37	3	19559530	19559530	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:19559530G>T	ENST00000328405.2	+	15	2849	c.2583G>T	c.(2581-2583)gaG>gaT	p.E861D		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	861						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TCAAAGCAGAGGAGACCAAGC	0.408000													8	24					0.307466	0.309605	0.307466	1	0
TRIM56	81844	broad.mit.edu	37	7	100732770	100732770	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100732770G>A	ENST00000306085.6	+	3	2474	c.2177G>A	c.(2176-2178)cGg>cAg	p.R726Q		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	726					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAAAGCCCCGGGTTACCACC	0.577000													10	93					0	0	0.457914	0	0
JRK	8629	broad.mit.edu	37	8	143747287	143747287	+	RNA	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:143747287C>G	ENST00000507178.2	-	0	523									jerky homolog (mouse)													all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				ggcgaagaaccggagcagctg	0.647000													6	28					0	0	0.248553	0	0
ABCA2	20	broad.mit.edu	37	9	139910499	139910499	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:139910499C>A	ENST00000265662.5	-	22	3379	c.3232G>T	c.(3232-3234)Gac>Tac	p.D1078Y	ABCA2_ENST00000341511.6_Missense_Mutation_p.D1078Y|ABCA2_ENST00000371605.3_Missense_Mutation_p.D1077Y			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1077	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.D1078H(1)		central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTGAGCCGGTCAAAGAGCACA	0.602000													83	89					1.63847e-34	3.41105e-34	0.870114	1	0
TMEM196	256130	broad.mit.edu	37	7	19761703	19761703	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19761703C>T	ENST00000405764.3	-	4	1210	c.514G>A	c.(514-516)Gtg>Atg	p.V172M	TMEM196_ENST00000493519.1_Missense_Mutation_p.V104M|TMEM196_ENST00000433641.1_3'UTR|TMEM196_ENST00000422233.1_3'UTR|TMEM196_ENST00000405844.1_3'UTR	NM_152774.3	NP_689987.3	Q5HYL7	TM196_HUMAN	transmembrane protein 196	178						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						ATTGATTACACTCTTCCATTA	0.313000													33	71					0	0	0.834066	0	0
SLC25A14	9016	broad.mit.edu	37	X	129474306	129474306	+	Silent	SNP	G	G	T	rs150106204	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:129474306G>T	ENST00000218197.5	+	1	281	c.54G>T	c.(52-54)acG>acT	p.T18T	SLC25A14_ENST00000543953.1_Intron|SLC25A14_ENST00000361980.5_Silent_p.T18T|SLC25A14_ENST00000339231.3_Silent_p.T18T|SLC25A14_ENST00000467496.1_3'UTR|SLC25A14_ENST00000545805.1_Silent_p.T18T	NM_003951.2|NM_022810.1	NP_003942.1|NP_073721.1	O95258	UCP5_HUMAN	solute carrier family 25 (mitochondrial carrier, brain), member 14	18					aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)	22						AGTTTGCAACGGCGGCCGTGA	0.483000													14	47					3.41278e-10	4.73662e-10	0.520397	1	0
GRID2	2895	broad.mit.edu	37	4	94031940	94031940	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:94031940C>A	ENST00000282020.4	+	4	829	c.571C>A	c.(571-573)Cag>Aag	p.Q191K	GRID2_ENST00000510992.1_Missense_Mutation_p.Q96K|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	191					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGTCTCTCAGCAGGGAATGGA	0.393000													22	93					1.42536e-11	2.07465e-11	0.681144	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872754	51872754	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:51872754G>T	ENST00000371497.5	+	2	3644	c.2757G>T	c.(2755-2757)atG>atT	p.M919I	TSHZ2_ENST00000603338.2_Missense_Mutation_p.M916I|RP4-678D15.1_ENST00000606932.1_RNA|TSHZ2_ENST00000329613.6_Missense_Mutation_p.M916I	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	919					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGAAAAACATGGACAAAGGCC	0.473000													25	59					2.4375e-19	4.29932e-19	0.717897	1	0
ZBED2	79413	broad.mit.edu	37	3	111312891	111312891	+	Missense_Mutation	SNP	C	C	A	rs144737275	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:111312891C>A	ENST00000317012.4	-	2	1166	c.158G>T	c.(157-159)cGg>cTg	p.R53L	CD96_ENST00000283285.5_Intron|CD96_ENST00000352690.4_Intron|CD96_ENST00000438817.2_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	53							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						CTCAGAGAACCGGGTGCCCTT	0.562000													32	14					1.30015e-28	2.60307e-28	0.804634	1	0
KLB	152831	broad.mit.edu	37	4	39439400	39439400	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:39439400G>T	ENST00000257408.4	+	3	1487	c.1390G>T	c.(1390-1392)Gat>Tat	p.D464Y		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	464	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						GTCTCTCCTGGATGGCTTTGA	0.423000													111	89					1.33314e-76	3.03016e-76	0.870114	1	0
MTUS2	23281	broad.mit.edu	37	13	29600683	29600683	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:29600683G>T	ENST00000431530.3	+	1	1936	c.1878G>T	c.(1876-1878)gaG>gaT	p.E626D		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	616						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AGGGAATGGAGAACTATCAGG	0.517000													4	20					0.014758	0.0152943	0.184627	1	0
TRIML2	205860	broad.mit.edu	37	4	189012581	189012581	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:189012581G>C	ENST00000512729.1	-	7	1484	c.1110C>G	c.(1108-1110)gaC>gaG	p.D370E	TRIML2_ENST00000326754.3_Missense_Mutation_p.D395E	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	370	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TGGTGAGGGAGTCTGGACTTG	0.473000													18	50					0	0	0.639603	0	0
PLCB1	23236	broad.mit.edu	37	20	8628601	8628601	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:8628601G>T	ENST00000378641.3	+	6	993		c.e6+1		PLCB1_ENST00000338037.6_Splice_Site|PLCB1_ENST00000378637.2_Splice_Site	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTCTCAAAAAGTAAGCTTTGT	0.383000													30	62					1.47244e-24	2.82481e-24	0.819951	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68705754	68705754	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:68705754G>T	ENST00000255078.3	+	14	2827	c.2716G>T	c.(2716-2718)Gtc>Ttc	p.V906F		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	906					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CACAGCCGGCGTCACAACCCT	0.637000													15	37					6.94344e-10	9.5106e-10	0.539581	1	0
IFNA1	3439	broad.mit.edu	37	9	21440600	21440600	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:21440600C>A	ENST00000276927.1	+	1	161	c.94C>A	c.(94-96)Ctg>Atg	p.L32M		NM_024013.2	NP_076918.1	P01562	IFNA1_HUMAN	interferon, alpha 1	32					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)	7				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)		GACCCACAGCCTGGATAACAG	0.537000													20	75					1.13719e-10	1.61281e-10	0.729181	1	0
ATP6V0D2	245972	broad.mit.edu	37	8	87155156	87155156	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:87155156A>G	ENST00000285393.3	+	5	754	c.612A>G	c.(610-612)acA>acG	p.T204T	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	204					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						GTGATGTCACAGCAGAAGTTA	0.289000													63	180					0	0	0.870114	0	0
MUC2	4583	broad.mit.edu	37	11	1099265	1099265	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:1099265C>A	ENST00000441003.2	+	38	7271	c.7244C>A	c.(7243-7245)cCc>cAc	p.P2415H		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4777						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCAGAAGAGCCCACGTGCAAA	0.622000													12	59					7.93312e-07	9.63234e-07	0.457914	1	0
DNAH10	196385	broad.mit.edu	37	12	124387523	124387523	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:124387523G>A	ENST00000409039.3	+	56	9349	c.9324G>A	c.(9322-9324)atG>atA	p.M3108I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3108	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAAAGGCCATGGAGATAGAGG	0.602000													5	7					0	0	0.184627	0	0
SNX14	57231	broad.mit.edu	37	6	86253015	86253015	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:86253015C>A	ENST00000314673.3	-	14	1450	c.1274G>T	c.(1273-1275)gGc>gTc	p.G425V	SNX14_ENST00000505648.1_Missense_Mutation_p.G373V|SNX14_ENST00000513865.1_Intron|SNX14_ENST00000369627.2_Missense_Mutation_p.G425V|SNX14_ENST00000346348.3_Missense_Mutation_p.G381V|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	425	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		TATGTATGGGCCTTCAGCAAC	0.299000													14	15					3.41278e-10	4.73662e-10	0.520397	1	0
DPYS	1807	broad.mit.edu	37	8	105456551	105456551	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:105456551C>A	ENST00000351513.2	-	4	850	c.718G>T	c.(718-720)Gtg>Ttg	p.V240L		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	240					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGACAGTTCACAGCGCTGGCT	0.557000													18	76					1.67942e-08	2.1858e-08	0.539581	1	0
MYH7	4625	broad.mit.edu	37	14	23884428	23884428	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:23884428G>A	ENST00000355349.3	-	37	5497	c.5335C>T	c.(5335-5337)Ctg>Ttg	p.L1779L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1779					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ATGCGCTCCAGGTGGGCGCTG	0.597000													28	93					0	0	0.769981	0	0
FAM71F1	84691	broad.mit.edu	37	7	128369990	128369990	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:128369990C>A	ENST00000315184.5	+	6	941	c.888C>A	c.(886-888)tgC>tgA	p.C296*	FAM71F1_ENST00000485070.1_Nonsense_Mutation_p.C195*	NM_032599.2	NP_115988.1	Q96KD3	F71F1_HUMAN	family with sequence similarity 71, member F1	296										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18						GCATCCCTTGCACCTGTGACC	0.527000													80	91					3.89792e-41	8.41272e-41	0.870114	1	0
CSN2	1447	broad.mit.edu	37	4	70823285	70823285	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:70823285G>T	ENST00000353151.3	-	5	393	c.382C>A	c.(382-384)Cct>Act	p.P128T		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	128					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						GGGATTTGAGGGTCAAAAAAG	0.468000													8	29					7.48243e-07	9.12042e-07	0.335167	1	0
TENM1	10178	broad.mit.edu	37	X	123554636	123554636	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123554636C>G	ENST00000422452.2	-	25	4570	c.4507G>C	c.(4507-4509)Gcc>Ccc	p.A1503P	TENM1_ENST00000371130.3_Missense_Mutation_p.A1496P|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GAGGAAGGGGCTTTCATCTTT	0.468000													20	85					0	0	0.706142	0	0
C10orf54	64115	broad.mit.edu	37	10	73515147	73515147	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:73515147G>C	ENST00000394957.3	-	4	703	c.645C>G	c.(643-645)gtC>gtG	p.V215V	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	215						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						TTTGCTTGTAGACCAGGAGCA	0.632000													8	17					0	0	0.361761	0	0
GLA	2717	broad.mit.edu	37	X	100653866	100653866	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:100653866C>A	ENST00000218516.3	-	5	729	c.708G>T	c.(706-708)tgG>tgT	p.W236C	RPL36A-HNRNPH2_ENST00000409170.3_Intron|GLA_ENST00000493905.1_5'UTR	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	236			W -> C (in FD).|W -> L (in FD).		glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	TTATACTTTTCCAGGAATCAT	0.398000													17	77					1.02788e-11	1.5066e-11	0.520397	1	0
INHBA	3624	broad.mit.edu	37	7	41730112	41730112	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:41730112C>G	ENST00000242208.4	-	3	663	c.417G>C	c.(415-417)gaG>gaC	p.E139D	INHBA_ENST00000442711.1_Missense_Mutation_p.E139D|INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	139					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity	p.E139D(1)		biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CCTTGGAAATCTCGAAGTGCA	0.488000										TSP Lung(11;0.080)			10	18					0	0	0.335167	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955638	51955638	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:51955638C>T	ENST00000321424.3	-	7	1561	c.1495G>A	c.(1495-1497)Ggc>Agc	p.G499S	SIGLEC8_ENST00000430817.1_Missense_Mutation_p.G390S|SIGLEC8_ENST00000340550.5_Missense_Mutation_p.G406S	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	499					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAGAATCAGCCTCTGACTTCT	0.502000													34	20					0	0	0.827153	0	0
VWF	7450	broad.mit.edu	37	12	6143944	6143944	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:6143944G>A	ENST00000261405.5	-	20	2849	c.2595C>T	c.(2593-2595)gcC>gcT	p.A865A		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	865					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGGAGCACGTGGCATCACACA	0.582000													35	55					0	0	0.796494	0	0
KCNK9	51305	broad.mit.edu	37	8	140631106	140631106	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:140631106C>T	ENST00000520439.1	-	2	583	c.520G>A	c.(520-522)Ggg>Agg	p.G174R	KCNK9_ENST00000303015.1_Missense_Mutation_p.G174R			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	174						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GCGGCCGCCCCGATGCACAGC	0.567000													30	22					0	0	0.729181	0	0
CASS4	57091	broad.mit.edu	37	20	55033543	55033543	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:55033543G>A	ENST00000371336.3	+	6	2302	c.2101G>A	c.(2101-2103)Gag>Aag	p.E701K	CASS4_ENST00000434344.1_Missense_Mutation_p.E264K|CASS4_ENST00000360314.3_Missense_Mutation_p.E701K	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	701					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CCAGCCCGCGGAGATCATCAC	0.592000													12	120					0	0	0.500413	0	0
PHF20L1	51105	broad.mit.edu	37	8	133844551	133844551	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:133844551G>T	ENST00000395386.2	+	15	2115	c.1816G>T	c.(1816-1818)Ggg>Tgg	p.G606W	PHF20L1_ENST00000395390.2_Missense_Mutation_p.G581W|PHF20L1_ENST00000220847.7_5'UTR	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	606							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TCGATCTTCTGGGAGTTCTCT	0.408000													48	87					2.76378e-25	5.32935e-25	0.870114	1	0
GANAB	23193	broad.mit.edu	37	11	62402389	62402389	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:62402389G>A	ENST00000346178.4	-	5	479	c.464C>T	c.(463-465)cCa>cTa	p.P155L	GANAB_ENST00000534779.1_Missense_Mutation_p.P41L|GANAB_ENST00000540933.1_Missense_Mutation_p.P58L|GANAB_ENST00000356638.3_Missense_Mutation_p.P155L|GANAB_ENST00000534422.1_5'UTR	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	155					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						AAGGCGGAATGGCCGTGCTGT	0.512000													24	111					0	0	0.706142	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18644445	18644445	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:18644445C>T	ENST00000433979.1	+	19	2739	c.2623C>T	c.(2623-2625)Cat>Tat	p.H875Y	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.H916Y|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.H875Y	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	875					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AAATACTTGTCATCTTCCTCT	0.323000													11	64					0	0	0.457914	0	0
ABCC11	85320	broad.mit.edu	37	16	48234196	48234196	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:48234196G>A	ENST00000394747.1	-	14	2422	c.2073C>T	c.(2071-2073)caC>caT	p.H691H	ABCC11_ENST00000356608.2_Silent_p.H691H|ABCC11_ENST00000394748.1_Silent_p.H691H|ABCC11_ENST00000537808.1_Silent_p.H691H|ABCC11_ENST00000353782.5_Silent_p.H691H	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	691	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCTGCAGCTGGTGGGTCACCA	0.537000													27	28					0	0	0.769981	0	0
FAM155B	27112	broad.mit.edu	37	X	68749626	68749626	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:68749626G>T	ENST00000252338.4	+	3	1288	c.1246G>T	c.(1246-1248)Gcc>Tcc	p.A416S		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	417						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						CAACAAGCCCGCCCTGCTGCC	0.607000													8	33					5.18039e-06	6.09725e-06	0.278610	1	0
CSMD3	114788	broad.mit.edu	37	8	113694814	113694814	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:113694814C>A	ENST00000297405.5	-	16	2778	c.2534G>T	c.(2533-2535)cGg>cTg	p.R845L	CSMD3_ENST00000455883.2_Missense_Mutation_p.R741L|CSMD3_ENST00000343508.3_Missense_Mutation_p.R805L|CSMD3_ENST00000352409.3_Missense_Mutation_p.R845L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	845	Sushi 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTCCCCAAACCGCCGTGCATT	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			81	52					9.79205e-48	2.16045e-47	0.870114	1	0
TRIM6	117854	broad.mit.edu	37	11	5624865	5624865	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:5624865G>A	ENST00000380097.3	+	2	649	c.407G>A	c.(406-408)tGt>tAt	p.C136Y	TRIM6_ENST00000515022.1_Intron|TRIM6-TRIM34_ENST00000354852.5_Missense_Mutation_p.C136Y|TRIM6_ENST00000506134.1_Intron|TRIM6_ENST00000278302.5_Missense_Mutation_p.C108Y|TRIM6_ENST00000507320.1_5'UTR|TRIM6_ENST00000445329.1_5'UTR|HBG2_ENST00000380259.2_Intron|TRIM6_ENST00000380107.1_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAGCTCTTCTGTCAGGAGGAT	0.562000													14	70					0	0	0.539581	0	0
AIM2	9447	broad.mit.edu	37	1	159035876	159035876	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:159035876G>C	ENST00000368130.4	-	4	928	c.640C>G	c.(640-642)Cgg>Ggg	p.R214G	AIM2_ENST00000481829.1_Intron	NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	214	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					CCACTGTGCCGATAATATCTT	0.358000													24	94					0	0	0.654019	0	0
MUC17	140453	broad.mit.edu	37	7	100675448	100675448	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:100675448G>T	ENST00000306151.4	+	3	815	c.751G>T	c.(751-753)Gct>Tct	p.A251S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	251	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GACCATTTCTGCTCAAGCCAG	0.493000													111	181					4.09656e-53	9.09167e-53	0.870114	1	0
NELL2	4753	broad.mit.edu	37	12	44917155	44917155	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:44917155G>T	ENST00000429094.2	-	17	2421	c.1917C>A	c.(1915-1917)gaC>gaA	p.D639E	NELL2_ENST00000551601.1_Missense_Mutation_p.D591E|NELL2_ENST00000549027.1_Missense_Mutation_p.D638E|NELL2_ENST00000333837.4_Missense_Mutation_p.D662E|NELL2_ENST00000395487.2_Missense_Mutation_p.D638E|NELL2_ENST00000452445.2_Missense_Mutation_p.D639E|NELL2_ENST00000437801.2_Missense_Mutation_p.D689E	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	639	VWFC 3.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CATGGATGCAGTCCCCTGTGC	0.458000													57	102					8.81991e-31	1.79449e-30	0.870114	1	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212207	90212207	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:90212207C>A	ENST00000390277.2	+	0	396																											AGCCTAGAGCCTGAAGATTTT	0.502000													21	74					1.88708e-17	3.19379e-17	0.729181	1	0
GINS4	84296	broad.mit.edu	37	8	41397472	41397472	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:41397472G>T	ENST00000523277.2	+	6	600	c.433G>T	c.(433-435)Gcc>Tcc	p.A145S	GINS4_ENST00000518671.1_Missense_Mutation_p.A145S|RP11-360L9.4_ENST00000523081.1_RNA|GINS4_ENST00000276533.3_Missense_Mutation_p.A145S			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	145					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			GAAAAATGTCGCCTTGAAGCA	0.527000													13	82					1.5739e-10	2.22045e-10	0.500413	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106849345	106849345	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:106849345C>A	ENST00000526355.1	-	3	955	c.487_splice	c.e3+1	p.G163_splice	GUCY1A2_ENST00000347596.2_Splice_Site_p.G163_splice|GUCY1A2_ENST00000282249.2_Splice_Site_p.G163_splice	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	163					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTTAATATACCGAGTATATTA	0.368000													5	42					0.00116845	0.00125586	0.217242	1	0
DPP9	91039	broad.mit.edu	37	19	4702635	4702635	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:4702635C>T	ENST00000262960.9	-	8	1140	c.863G>A	c.(862-864)tGc>tAc	p.C288Y	DPP9_ENST00000594671.1_Missense_Mutation_p.C259Y|DPP9_ENST00000597849.1_Missense_Mutation_p.C288Y|DPP9_ENST00000598800.1_Missense_Mutation_p.C259Y	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	259					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GGCTGTGGGGCACCACCAGTA	0.572000													6	22					0	0	0.278610	0	0
IRF8	3394	broad.mit.edu	37	16	85952132	85952132	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:85952132C>G	ENST00000268638.5	+	7	1133	c.711C>G	c.(709-711)ccC>ccG	p.P237P	IRF8_ENST00000562492.1_Silent_p.P33P	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	237					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				CTGGGCTGCCCGGCACCAAGC	0.697000													8	22					0	0	0.278610	0	0
FMO3	2328	broad.mit.edu	37	1	171083399	171083399	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:171083399A>G	ENST00000367755.4	+	7	1191	c.1080A>G	c.(1078-1080)ctA>ctG	p.L360L	FMO3_ENST00000538429.1_Silent_p.L297L|FMO3_ENST00000542847.1_Silent_p.L340L|FMO3_ENST00000392085.2_Silent_p.L360L	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	360			L -> P (in dbSNP:rs28363581).		xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCCTCCTCTACTTGAGAAGT	0.448000													5	59					0	0	0.184627	0	0
CCT6B	10693	broad.mit.edu	37	17	33278998	33278998	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:33278998C>G	ENST00000314144.5	-	5	700	c.585G>C	c.(583-585)gaG>gaC	p.E195D	CCT6B_ENST00000421975.3_Missense_Mutation_p.E195D|CCT6B_ENST00000436961.3_Missense_Mutation_p.E150D	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	195					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TATGCTTCATCTCCATTATTT	0.313000													6	34					0	0	0.217242	0	0
SH3TC2	79628	broad.mit.edu	37	5	148407765	148407765	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:148407765G>A	ENST00000538184.1	-	7	1059	c.171C>T	c.(169-171)taC>taT	p.Y57Y	SH3TC2_ENST00000394358.2_Silent_p.Y395Y|SH3TC2_ENST00000515425.1_Silent_p.Y510Y|SH3TC2_ENST00000512049.1_Silent_p.Y503Y			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	510							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCTCCAGGTAGGCCACAA	0.517000													16	155					0	0	0.479597	0	0
BRS3	680	broad.mit.edu	37	X	135570598	135570598	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:135570598C>A	ENST00000370648.3	+	1	553	c.325C>A	c.(325-327)Ctt>Att	p.L109I		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	109					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					AACTCACTACCTTGCAGAAGG	0.438000													29	148					5.91797e-21	1.08237e-20	0.760397	1	0
NUTM2F	54754	broad.mit.edu	37	9	97088125	97088125	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:97088125G>T	ENST00000335456.7	-	2	128	c.108C>A	c.(106-108)ggC>ggA	p.G36G	NUTM2F_ENST00000253262.4_Silent_p.G36G|NUTM2F_ENST00000341207.4_Silent_p.G36G					NUT family member 2F																		TGTGTGCTGGGCCGGGAGCGG	0.667000													28	35					1.06801e-11	1.56298e-11	0.740014	1	0
PAX5	5079	broad.mit.edu	37	9	37015066	37015066	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:37015066T>A	ENST00000358127.4	-	3	412	c.338A>T	c.(337-339)gAg>gTg	p.E113V	PAX5_ENST00000377853.2_Missense_Mutation_p.E113V|PAX5_ENST00000520281.1_Missense_Mutation_p.E113V|PAX5_ENST00000520154.1_Missense_Mutation_p.E113V|PAX5_ENST00000414447.1_Missense_Mutation_p.E113V|PAX5_ENST00000523145.1_Missense_Mutation_p.E5V|PAX5_ENST00000522003.1_Missense_Mutation_p.E5V|PAX5_ENST00000377852.2_Missense_Mutation_p.E113V|PAX5_ENST00000446742.1_Intron|PAX5_ENST00000377847.2_Missense_Mutation_p.E113V|PAX5_ENST00000523241.1_Missense_Mutation_p.E113V	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	113	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(42)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GTCCCTGATCTCCCAGGCAAA	0.557000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								75	263					0	0	0.870114	0	0
VPS13B	157680	broad.mit.edu	37	8	100732583	100732583	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:100732583G>T	ENST00000358544.2	+	38	6854	c.6743G>T	c.(6742-6744)gGt>gTt	p.G2248V	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.G2223V	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2248					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTCTTCTGGGGTCAAGAACAT	0.299000													7	33					0.000157383	0.000174438	0.278610	1	0
PCDH15	65217	broad.mit.edu	37	10	55566785	55566785	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:55566785G>A	ENST00000373965.2	-	36	5003	c.4609C>T	c.(4609-4611)Cct>Tct	p.P1537S	PCDH15_ENST00000414778.1_Missense_Mutation_p.P1534S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGATACTAGGATGGTGAAGA	0.433000										HNSCC(58;0.16)			8	14					0	0	0.307466	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432837	73432837	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:73432837G>T	ENST00000263666.4	-	10	2994	c.2880C>A	c.(2878-2880)gaC>gaA	p.D960E	PDZRN3_ENST00000462146.2_Missense_Mutation_p.D617E|PDZRN3_ENST00000535920.1_Missense_Mutation_p.D682E|PDZRN3_ENST00000479530.1_Missense_Mutation_p.D677E|PDZRN3_ENST00000466780.1_Missense_Mutation_p.D617E	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	960							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCGCGTCGTCGTCGGTGGTCA	0.687000													15	51					2.5808e-16	4.26058e-16	0.539581	1	0
KIAA1211	57482	broad.mit.edu	37	4	57193875	57193875	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:57193875C>A	ENST00000504228.1	+	9	3712	c.3607C>A	c.(3607-3609)Ccg>Acg	p.P1203T	KIAA1211_ENST00000541073.1_Missense_Mutation_p.P1196T|KIAA1211_ENST00000264229.6_Missense_Mutation_p.P1203T			Q6ZU35	K1211_HUMAN	KIAA1211	1203										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GTTTTCCACCCCGGATGCTGC	0.507000													477	124					1.08331e-242	2.50159e-242	0.870114	1	0
SALL4	57167	broad.mit.edu	37	20	50405641	50405641	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:50405641G>A	ENST00000217086.4	-	3	2612	c.2501C>T	c.(2500-2502)cCg>cTg	p.P834L	SALL4_ENST00000371539.3_Missense_Mutation_p.P57L|SALL4_ENST00000395997.3_Missense_Mutation_p.P397L	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	834					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GACATAGGTCGGCGGGGCTCG	0.542000													15	61					0	0	0.557998	0	0
ZNF484	83744	broad.mit.edu	37	9	95610574	95610574	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:95610574G>C	ENST00000395505.2	-	3	479	c.387C>G	c.(385-387)aaC>aaG	p.N129K	ZNF484_ENST00000395506.3_Missense_Mutation_p.N167K|ZNF484_ENST00000332591.6_Missense_Mutation_p.N129K|ZNF484_ENST00000375495.3_Missense_Mutation_p.N165K|ANKRD19P_ENST00000473204.1_RNA	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						CCAGGTGTGTGTTTACATGAA	0.358000													45	52					0	0	0.870114	0	0
ZNF70	7621	broad.mit.edu	37	22	24086753	24086753	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:24086753C>A	ENST00000341976.3	-	2	1035	c.575G>T	c.(574-576)gGg>gTg	p.G192V		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	192						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						GGGCTTCTCCCCGGTGTGGAT	0.617000													14	30					4.7546e-09	6.31933e-09	0.500413	1	0
TP73-AS1	57212	broad.mit.edu	37	1	3662330	3662330	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:3662330C>A	ENST00000452079.1	-	0	1556				TP73-AS1_ENST00000423764.1_RNA|TP73-AS1_ENST00000418088.1_RNA|TP73-AS1_ENST00000544565.1_RNA	NR_033711.1																						GCAGCAGTGCCGGGCTCCCGA	0.632000													17	14					1.56452e-12	2.34991e-12	0.557998	1	0
ALDH5A1	7915	broad.mit.edu	37	6	24503613	24503613	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:24503613G>T	ENST00000357578.3	+	3	706	c.561G>T	c.(559-561)cgG>cgT	p.R187R	ALDH5A1_ENST00000546278.1_Silent_p.R99R|ALDH5A1_ENST00000491546.1_Silent_p.R159R|ALDH5A1_ENST00000348925.2_Silent_p.R187R	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	187					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	AGGACAGGCGGGCCCTGGTCC	0.557000													8	61					1.58986e-06	1.90703e-06	0.361761	1	0
C19orf25	148223	broad.mit.edu	37	19	1478827	1478827	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:1478827C>A	ENST00000436106.2	-	2	471	c.76G>T	c.(76-78)Gat>Tat	p.D26Y	C19orf25_ENST00000588871.1_Missense_Mutation_p.D26Y|C19orf25_ENST00000427685.2_Missense_Mutation_p.D26Y|C19orf25_ENST00000588427.1_Missense_Mutation_p.D26Y|C19orf25_ENST00000591027.1_5'UTR|C19orf25_ENST00000592872.1_Missense_Mutation_p.D26Y|C19orf25_ENST00000588849.1_Missense_Mutation_p.D26Y|C19orf25_ENST00000586564.1_Missense_Mutation_p.D26Y|C19orf25_ENST00000585675.1_Missense_Mutation_p.D26Y			Q9UFG5	CS025_HUMAN	chromosome 19 open reading frame 25	26							protein binding						Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCGCACATCCTCCAGGATC	0.701000													18	7					2.39187e-15	3.83433e-15	0.575678	1	0
KRT73	319101	broad.mit.edu	37	12	53008438	53008438	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:53008438C>A	ENST00000305748.3	-	4	778	c.744G>T	c.(742-744)acG>acT	p.T248T	RP11-641A6.2_ENST00000552364.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	248	Coil 1B.|Rod.		T -> M (in a colorectal cancer sample; somatic mutation).			keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCACTTTGCTCGTGTAAGCTG	0.572000													17	30					5.03518e-11	7.21722e-11	0.557998	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885827	88885827	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:88885827G>A	ENST00000319675.3	-	1	469	c.373C>T	c.(373-375)Cgg>Tgg	p.R125W		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	125								p.R125W(2)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						TTCACCTTCCGATTAGGGACG	0.557000													75	59					0	0	0.870114	0	0
CSTF1	1477	broad.mit.edu	37	20	54978523	54978523	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:54978523G>T	ENST00000217109.4	+	6	1388		c.e6-1		CSTF1_ENST00000493039.1_Splice_Site	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			CTCTGTGGCAGGCGCGGGTTT	0.502000													11	77					2.27111e-07	2.82127e-07	0.411799	1	0
ADCY1	107	broad.mit.edu	37	7	45719308	45719308	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:45719308G>T	ENST00000297323.7	+	11	1921	c.1898_splice	c.e11-1	p.Q633_splice		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	633					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	TGTCCCCCAGGAGTGTGGTCG	0.582000													12	79					1.05317e-09	1.43006e-09	0.457914	1	0
SLC5A9	200010	broad.mit.edu	37	1	48697711	48697711	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:48697711C>A	ENST00000236495.5	+	8	910	c.860C>A	c.(859-861)cCa>cAa	p.P287Q	SLC5A9_ENST00000420136.2_Intron|SLC5A9_ENST00000533824.1_Missense_Mutation_p.P283Q|SLC5A9_ENST00000438567.2_Missense_Mutation_p.P262Q	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	262						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						TGTCACCTCCCACGGCCCGAT	0.617000													26	75					0.00209593	0.00223994	0.750413	1	0
COL4A2	1284	broad.mit.edu	37	13	111147779	111147779	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:111147779G>C	ENST00000360467.5	+	40	4031	c.3725G>C	c.(3724-3726)gGa>gCa	p.G1242A		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1242	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCCCTGTGGGAGTCCCAGGA	0.612000													9	708					0	0	0.335167	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98380292	98380292	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:98380292C>A	ENST00000339364.5	-	12	1877	c.1758G>T	c.(1756-1758)agG>agT	p.R586S	PIK3AP1_ENST00000371109.3_Missense_Mutation_p.R185S|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.R408S	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	586						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GGGGCCTGTCCCTCCATGGTC	0.577000													4	11					0.014758	0.0152943	0.184627	1	0
TAS1R2	80834	broad.mit.edu	37	1	19166287	19166287	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:19166287G>T	ENST00000375371.3	-	6	2347	c.2326C>A	c.(2326-2328)Ctc>Atc	p.L776I		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	776					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AAGGTGCAGAGGGAGACGGAT	0.562000													12	32					4.3838e-07	5.36431e-07	0.435327	1	0
RHAG	6005	broad.mit.edu	37	6	49585844	49585844	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:49585844G>T	ENST00000371175.4	-	3	455	c.429C>A	c.(427-429)atC>atA	p.I143I	RHAG_ENST00000229810.7_Silent_p.I143I	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	143					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					AAATTGTCATGATCAGCATTT	0.388000													12	22					5.50884e-06	6.43952e-06	0.411799	1	0
HCN1	348980	broad.mit.edu	37	5	45645491	45645491	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:45645491C>A	ENST00000303230.4	-	2	702	c.645G>T	c.(643-645)atG>atT	p.M215I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	215						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTAAATAATTCATCTTGATCA	0.368000													3	16					0.004672	0.00492037	0.115264	1	0
ACAN	176	broad.mit.edu	37	15	89403616	89403616	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:89403616G>T	ENST00000439576.2	+	13	7266	c.6892G>T	c.(6892-6894)Gga>Tga	p.G2298*	ACAN_ENST00000352105.7_Intron|ACAN_ENST00000561243.1_Nonsense_Mutation_p.G2298*|ACAN_ENST00000559004.1_Intron	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2298					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGAGACAGAGGGACACGTCAT	0.627000													20	25					3.73988e-18	6.45138e-18	0.706142	1	0
CLDN25	644672	broad.mit.edu	37	11	113650948	113650948	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:113650948C>A	ENST00000453129.2	+	1	480	c.431C>A	c.(430-432)aCa>aAa	p.T144K		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	144						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						GCCCATGCCACAATCCAAGAC	0.567000													8	25					0.000157383	0.000174438	0.278610	1	0
ACAN	176	broad.mit.edu	37	15	89415265	89415265	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:89415265G>T	ENST00000439576.2	+	15	7511	c.7137G>T	c.(7135-7137)ctG>ctT	p.L2379L	ACAN_ENST00000352105.7_Silent_p.L2341L|ACAN_ENST00000561243.1_Silent_p.L2379L|ACAN_ENST00000559004.1_Silent_p.L2341L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2379					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGATCGGCCTGAACGACAGGA	0.592000													10	91					3.27435e-08	4.2035e-08	0.457914	1	0
MYH7	4625	broad.mit.edu	37	14	23884426	23884426	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:23884426C>A	ENST00000355349.3	-	37	5499	c.5337G>T	c.(5335-5337)ctG>ctT	p.L1779L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1779					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCATGCGCTCCAGGTGGGCGC	0.602000													27	89					8.4185e-14	1.30723e-13	0.760397	1	0
CTSL	1514	broad.mit.edu	37	9	90343659	90343659	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:90343659G>C	ENST00000343150.5	+	5	1446	c.556G>C	c.(556-558)Gct>Cct	p.A186P	CTSL_ENST00000495822.1_3'UTR|CTSL_ENST00000342020.5_Missense_Mutation_p.A186P|CTSL_ENST00000340342.6_Missense_Mutation_p.A186P					cathepsin L																		AATGGATTATGCTTTCCAGTA	0.498000													19	35					0	0	0.575678	0	0
ZNF239	8187	broad.mit.edu	37	10	44053267	44053267	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:44053267C>A	ENST00000306006.6	-	2	913	c.261G>T	c.(259-261)caG>caT	p.Q87H	ZNF239_ENST00000535642.1_Missense_Mutation_p.Q87H|ZNF239_ENST00000374446.2_Missense_Mutation_p.Q87H|ZNF239_ENST00000491188.1_5'UTR|ZNF239_ENST00000426961.1_Missense_Mutation_p.Q87H	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CCTGATGATCCTGAGGCTCAT	0.393000													38	50					5.48756e-27	1.07916e-26	0.859065	1	0
ENOX2	10495	broad.mit.edu	37	X	129759363	129759363	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:129759363C>A	ENST00000338144.3	-	16	2175	c.1758G>T	c.(1756-1758)caG>caT	p.Q586H	ENOX2_ENST00000370927.1_Missense_Mutation_p.Q586H|ENOX2_ENST00000370935.1_Missense_Mutation_p.Q557H|ENOX2_ENST00000394363.1_Missense_Mutation_p.Q557H	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	586					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						CAGTCATTTCCTGCTTGAAGG	0.473000													13	23					4.36969e-10	6.038e-10	0.435327	1	0
ADARB2	105	broad.mit.edu	37	10	1230921	1230921	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:1230921C>A	ENST00000381312.1	-	9	2248	c.1923G>T	c.(1921-1923)tgG>tgT	p.W641C	ADARB2_ENST00000381310.3_Missense_Mutation_p.W150C|ADARB2_ENST00000381305.1_Missense_Mutation_p.W43C	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	641	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		TGCCCACGACCCAGTTCATGC	0.667000													6	33					3.09899e-07	3.82696e-07	0.307466	1	0
RHOXF1	158800	broad.mit.edu	37	X	119243218	119243218	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:119243218T>A	ENST00000217999.2	-	3	561	c.487A>T	c.(487-489)Aga>Tga	p.R163*	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	163					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						ATTAATTCTCTCTGATGTCGC	0.438000													14	70					0	0	0.520397	0	0
BRD2	6046	broad.mit.edu	37	6	32943210	32943210	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:32943210G>C	ENST00000395289.2	+	4	1984	c.383G>C	c.(382-384)aGg>aCg	p.R128T	BRD2_ENST00000374831.4_Missense_Mutation_p.R128T|BRD2_ENST00000395287.1_Missense_Mutation_p.R128T|BRD2_ENST00000449085.2_Missense_Mutation_p.R81T|BRD2_ENST00000374825.4_Missense_Mutation_p.R128T|BRD2_ENST00000443797.2_Missense_Mutation_p.R8T			P25440	BRD2_HUMAN	bromodomain containing 2	128	Bromo 1.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						ACTATTAAGAGGAGACTTGAA	0.318000													17	60					0	0	0.539581	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724722	7724722	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:7724722C>T	ENST00000303635.7	+	9	2322	c.2115C>T	c.(2113-2115)ctC>ctT	p.L705L	CAMTA1_ENST00000439411.2_Silent_p.L705L	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGTCCTGCTCAAGTCTGGGG	0.657000			T	WWTR1	epitheliod hemangioendothelioma								13	52					0	0	0.457914	0	0
EFCAB3	146779	broad.mit.edu	37	17	60464708	60464708	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:60464708G>T	ENST00000450662.2	+	5	309	c.238G>T	c.(238-240)Gac>Tac	p.D80Y	EFCAB3_ENST00000305286.3_Missense_Mutation_p.D28Y	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	28	EF-hand 1.						calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			CAGGGATAGAGACTTACCAGG	0.363000													10	64					1.08611e-07	1.36452e-07	0.387290	1	0
SLC6A3	6531	broad.mit.edu	37	5	1416254	1416254	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:1416254G>T	ENST00000270349.9	-	7	1117	c.990C>A	c.(988-990)atC>atA	p.I330I	SLC6A3_ENST00000453492.2_Silent_p.I330I	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	330					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TGGAGAAGGCGATCAGCACCC	0.617000													24	260					5.91797e-21	1.08237e-20	0.760397	1	0
ELK4	2005	broad.mit.edu	37	1	205589767	205589767	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:205589767G>A	ENST00000357992.4	-	3	746	c.407C>T	c.(406-408)tCt>tTt	p.S136F	ELK4_ENST00000289703.4_Missense_Mutation_p.S136F|ELK4_ENST00000468523.1_5'UTR	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATTGCGGCTAGAGGTCTTGGC	0.418000			T	SLC45A3	prostate								27	38					0	0	0.750413	0	0
IL6	3569	broad.mit.edu	37	7	22766896	22766896	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:22766896C>T	ENST00000404625.1	+	2	474	c.15C>T	c.(13-15)tcC>tcT	p.S5S	IL6_ENST00000406575.1_Silent_p.S5S|IL6_ENST00000401630.3_Silent_p.S5S|AC073072.5_ENST00000325042.2_RNA|IL6_ENST00000258743.5_Silent_p.S5S|IL6_ENST00000407492.1_5'UTR|IL6_ENST00000420258.2_Silent_p.S5S|IL6_ENST00000401651.1_5'UTR			P05231	IL6_HUMAN	interleukin 6 (interferon, beta 2)	5					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	ACTCCTTCTCCACAAGTAAGT	0.622000											OREG0017891	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	83					0	0	0.575678	0	0
PAPD7	11044	broad.mit.edu	37	5	6738808	6738808	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:6738808G>T	ENST00000230859.6	+	3	232	c.103G>T	c.(103-105)Ggc>Tgc	p.G35C		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	35					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						ACAGATATTTGGCAGCTTTAG	0.433000													35	309					1.57019e-19	2.79047e-19	0.834066	1	0
WT1	7490	broad.mit.edu	37	11	32413533	32413533	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:32413533G>A	ENST00000332351.3	-	9	1701	c.1417C>T	c.(1417-1419)Cat>Tat	p.H473Y	WT1_ENST00000530998.1_Missense_Mutation_p.H244Y|WT1_ENST00000448076.3_Missense_Mutation_p.H473Y|WT1_ENST00000379079.2_Missense_Mutation_p.H261Y	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	405					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TTACCTGTATGAGTCCTGGTG	0.393000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				34	208					0	0	0.840704	0	0
CDK13	8621	broad.mit.edu	37	7	40102635	40102635	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:40102635G>T	ENST00000181839.4	+	9	3321	c.2716G>T	c.(2716-2718)Gaa>Taa	p.E906*	CDK13_ENST00000340829.5_Nonsense_Mutation_p.E906*|CDK13_ENST00000484589.1_3'UTR	NM_003718.4|NM_031267.3	NP_003709.3|NP_112557.2	Q14004	CDK13_HUMAN	cyclin-dependent kinase 13	906	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						TATCCTTGGCGAACTCTTCAC	0.328000													14	32					3.52763e-06	4.165e-06	0.520397	1	0
RP1L1	94137	broad.mit.edu	37	8	10467857	10467857	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:10467857C>G	ENST00000382483.3	-	4	3974	c.3751G>C	c.(3751-3753)Gaa>Caa	p.E1251Q		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1251					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGTTGGTTTTCCAGATCCCCT	0.552000													23	46					0	0	0.693898	0	0
OR8K1	390157	broad.mit.edu	37	11	56113723	56113723	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:56113723G>A	ENST00000279783.2	+	1	303	c.209G>A	c.(208-210)aGa>aAa	p.R70K		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R70K(1)		large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TTTTTCCTTAGACATTTGTCA	0.403000										HNSCC(65;0.19)			65	78					0	0	0.870114	0	0
WDFY3	23001	broad.mit.edu	37	4	85600130	85600130	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:85600130G>A	ENST00000322366.6	-	64	10445	c.10038C>T	c.(10036-10038)ccC>ccT	p.P3346P	WDFY3_ENST00000295888.4_Silent_p.P3363P			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3363						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GGTGGCTAAGGGGGCCCTGCA	0.507000													34	50					0	0	0.819951	0	0
CELF5	60680	broad.mit.edu	37	19	3278099	3278099	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:3278099G>T	ENST00000541430.2	+	5	630	c.594G>T	c.(592-594)caG>caT	p.Q198H	CELF5_ENST00000292672.2_Missense_Mutation_p.Q198H	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	198	RRM 2.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						ATGGGAGCCAGACCATGCCGG	0.622000													15	32					2.94398e-08	3.78972e-08	0.557998	1	0
MAGI2	9863	broad.mit.edu	37	7	79082357	79082357	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:79082357G>A	ENST00000354212.4	-	1	533	c.280C>T	c.(280-282)Cgg>Tgg	p.R94W	MAGI2_ENST00000522391.1_Missense_Mutation_p.R94W|MAGI2_ENST00000419488.1_Missense_Mutation_p.R94W|MAGI2-AS3_ENST00000429408.1_RNA	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	94	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CACTTGAGCCGGAGGGGGTCC	0.662000													52	93					0	0	0.870114	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095360	103095360	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:103095360G>T	ENST00000295269.4	+	2	776	c.319G>T	c.(319-321)Ggg>Tgg	p.G107W		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	107					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CATCCTGGTGGGGGCGCTGGT	0.592000													20	60					5.45024e-15	8.69267e-15	0.654019	1	0
MEGF10	84466	broad.mit.edu	37	5	126676315	126676315	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:126676315G>T	ENST00000274473.6	+	5	579	c.312G>T	c.(310-312)atG>atT	p.M104I	MEGF10_ENST00000508365.1_Missense_Mutation_p.M104I|MEGF10_ENST00000503335.2_Missense_Mutation_p.M104I|MEGF10_ENST00000418761.2_Missense_Mutation_p.M104I	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	104	EMI.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		GCGGGGAAATGTGTGTCCGTA	0.473000													22	63					4.43304e-23	8.35969e-23	0.706142	1	0
OBSCN	84033	broad.mit.edu	37	1	228432196	228432196	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:228432196G>T	ENST00000570156.2	+	12	3755	c.3681G>T	c.(3679-3681)caG>caT	p.Q1227H	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.Q1135H|OBSCN_ENST00000284548.11_Missense_Mutation_p.Q1135H	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	173	Ig-like 12.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCTGCCACAGGCGGGCAAAG	0.577000													54	87					5.19286e-32	1.06228e-31	0.870114	1	0
N4BP3	23138	broad.mit.edu	37	5	177548132	177548132	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:177548132G>T	ENST00000274605.5	+	4	1245	c.886G>T	c.(886-888)Gag>Tag	p.E296*		NM_015111.1	NP_055926.1	O15049	N4BP3_HUMAN	NEDD4 binding protein 3	296						cytoplasmic vesicle membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGGCTGGCTGAGCTGAAGCG	0.642000											OREG0017096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	5					1.08611e-07	1.36452e-07	0.387290	1	0
MCM9	254394	broad.mit.edu	37	6	119234475	119234475	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:119234475C>G	ENST00000316316.6	-	6	1301	c.1015G>C	c.(1015-1017)Gga>Cga	p.G339R	MCM9_ENST00000316068.3_Missense_Mutation_p.G339R	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	339	MCM.				DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		ACCCGTGTTCCTGTAGCATCA	0.418000													10	68					0	0	0.387290	0	0
WNT5A	7474	broad.mit.edu	37	3	55504405	55504405	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:55504405C>A	ENST00000474267.1	-	6	1379	c.858G>T	c.(856-858)caG>caT	p.Q286H	WNT5A_ENST00000497027.1_Missense_Mutation_p.Q271H|WNT5A_ENST00000264634.4_Missense_Mutation_p.Q286H			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	286					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		GGCTGTTGACCTGTACCAACT	0.632000													6	16					0.00116845	0.00125586	0.217242	1	0
TENM1	10178	broad.mit.edu	37	X	123657476	123657476	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:123657476C>G	ENST00000422452.2	-	17	2835		c.e17-1		TENM1_ENST00000371130.3_Splice_Site	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GAGGTCAAAGCTAAGAAGGAA	0.413000													4	11					0	0	0.150653	0	0
ANK1	286	broad.mit.edu	37	8	41563735	41563735	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:41563735C>A	ENST00000396942.1	-	18	2106	c.2023G>T	c.(2023-2025)Gta>Tta	p.V675L	ANK1_ENST00000347528.4_Missense_Mutation_p.V675L|ANK1_ENST00000352337.4_Missense_Mutation_p.V675L|ANK1_ENST00000396945.1_Missense_Mutation_p.V675L|ANK1_ENST00000289734.7_Missense_Mutation_p.V675L|ANK1_ENST00000379758.2_Missense_Mutation_p.V675L|ANK1_ENST00000265709.8_Missense_Mutation_p.V708L			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	675	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTTGTGCTACCAGATGGAGG	0.532000													10	46					1.58986e-06	1.90703e-06	0.361761	1	0
ABCB5	340273	broad.mit.edu	37	7	20778742	20778742	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:20778742A>T	ENST00000404938.2	+	24	3656	c.3004A>T	c.(3004-3006)Agt>Tgt	p.S1002C	ABCB5_ENST00000258738.6_Missense_Mutation_p.S557C	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	557					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AGACAGCCGCAGTCAAGAAGG	0.473000													11	8					0	0	0.387290	0	0
CTIF	9811	broad.mit.edu	37	18	46383977	46383977	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:46383977G>A	ENST00000256413.3	+	11	1841	c.1546G>A	c.(1546-1548)Gtg>Atg	p.V516M	CTIF_ENST00000382998.4_Missense_Mutation_p.V518M	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	516	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						ATCTCAGGATGTGAAGGAAGA	0.567000													41	139					0	0	0.870114	0	0
KIFAP3	22920	broad.mit.edu	37	1	169941689	169941689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:169941689G>A	ENST00000367765.1	-	17	3329	c.1828C>T	c.(1828-1830)Cga>Tga	p.R610*	KIFAP3_ENST00000540905.1_Nonsense_Mutation_p.R352*|KIFAP3_ENST00000367767.1_Nonsense_Mutation_p.R606*|KIFAP3_ENST00000361580.2_Nonsense_Mutation_p.R650*|KIFAP3_ENST00000538366.1_Nonsense_Mutation_p.R572*	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	650					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGACCTTTCGGATTTCATTA	0.313000													3	27					0	0	0.115264	0	0
JAK3	3718	broad.mit.edu	37	19	17947978	17947978	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:17947978C>A	ENST00000458235.1	-	13	1845	c.1746G>T	c.(1744-1746)cgG>cgT	p.R582R	JAK3_ENST00000534444.1_Silent_p.R582R|JAK3_ENST00000527670.1_Silent_p.R582R	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	582	Protein kinase 1.		R -> W (in T(-)B(+)NK(-) SCID).		B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GCACGAGATGCCGGTACGACA	0.597000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								17	6					2.70639e-06	3.22369e-06	0.624587	1	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802693	31802693	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:31802693G>A	ENST00000334068.2	+	1	122	c.100G>A	c.(100-102)Gcc>Acc	p.A34T		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	34						intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						CTACAGCACTGCCCTCTGCTC	0.602000													30	77					0	0	0.819951	0	0
USH1C	10083	broad.mit.edu	37	11	17545010	17545010	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:17545010C>A	ENST00000005226.7	-	10	774	c.775G>T	c.(775-777)Gtc>Ttc	p.V259F	USH1C_ENST00000318024.4_Missense_Mutation_p.V259F|USH1C_ENST00000527020.1_Missense_Mutation_p.V259F|USH1C_ENST00000527720.1_Missense_Mutation_p.V228F	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	259	PDZ 2.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						TTGACTTCGACAATCTGGTCC	0.542000													13	12					1.5739e-10	2.22045e-10	0.500413	1	0
GPM6A	2823	broad.mit.edu	37	4	176556089	176556089	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:176556089A>T	ENST00000280187.7	-	8	849	c.804T>A	c.(802-804)acT>acA	p.T268T	GPM6A_ENST00000506894.1_Silent_p.T257T|GPM6A_ENST00000515090.1_Silent_p.T261T|GPM6A_ENST00000393658.2_Silent_p.T268T|GPM6A_ENST00000506219.1_5'UTR	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	268						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		CTTTGGAGCGAGTAGAGTGGA	0.468000													9	31					0	0	0.387290	0	0
GRK1	6011	broad.mit.edu	37	13	114322393	114322393	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:114322393G>A	ENST00000335678.6	+	1	924	c.692G>A	c.(691-693)gGc>gAc	p.G231D		NM_002929.2	NP_002920.1	Q15835	RK_HUMAN	G protein-coupled receptor kinase 1	231	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway|rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|rhodopsin kinase activity|signal transducer activity			ovary(2)	2	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.234)			AAGAGGAAGGGCTACCAGGTG	0.662000													3	5					0	0	0.150653	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763448	92763448	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:92763448T>A	ENST00000318238.4	-	5	3053	c.1837A>T	c.(1837-1839)Aat>Tat	p.N613Y	SAMD9L_ENST00000437805.1_Missense_Mutation_p.N613Y|SAMD9L_ENST00000411955.1_Missense_Mutation_p.N613Y	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	613										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGTTCTATATTTAAAGTGGAA	0.368000													15	161					0	0	0.624587	0	0
NPAT	4863	broad.mit.edu	37	11	108062850	108062850	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:108062850C>A	ENST00000278612.8	-	4	390	c.285G>T	c.(283-285)caG>caT	p.Q95H		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	95	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATTACCTGATCTGAGAAAGTG	0.323000													27	78					2.47316e-13	3.79648e-13	0.779181	1	0
PIK3C2A	5286	broad.mit.edu	37	11	17150887	17150887	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:17150887C>A	ENST00000265970.7	-	12	2358	c.2359G>T	c.(2359-2361)Gct>Tct	p.A787S	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.A407S|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	787					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TTGCCCAAAGCTTCTGGTCCC	0.388000													24	38					1.5548e-18	2.69938e-18	0.693898	1	0
FAT4	79633	broad.mit.edu	37	4	126242604	126242604	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:126242604C>A	ENST00000394329.3	+	1	5051	c.5038C>A	c.(5038-5040)Ctc>Atc	p.L1680I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1680	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTTGGACGCCTCTTTACTAT	0.453000													30	81					9.04072e-19	1.58129e-18	0.779181	1	0
TAS2R16	50833	broad.mit.edu	37	7	122635505	122635505	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:122635505C>A	ENST00000249284.2	-	1	249	c.184G>T	c.(184-186)Gca>Tca	p.A62S		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	62					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AGCATTGATGCCCACTGTAGA	0.418000													5	87					3.09899e-07	3.82696e-07	0.307466	1	0
C4orf50	389197	broad.mit.edu	37	4	5961248	5961248	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:5961248G>T	ENST00000531445.1	-	7	2153	c.2107C>A	c.(2107-2109)Ccc>Acc	p.P703T	C4orf50_ENST00000324058.5_Missense_Mutation_p.P229T			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	229										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						GCAGGACAGGGCATTCCGCCT	0.567000													33	41					1.71298e-08	2.2264e-08	0.788014	1	0
KRTAP12-3	386683	broad.mit.edu	37	21	46078062	46078062	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:46078062G>A	ENST00000397907.1	+	1	214	c.166G>A	c.(166-168)Gtg>Atg	p.V56M	TSPEAR_ENST00000323084.4_Intron	NM_198697.2	NP_941970.2	P60328	KR123_HUMAN	keratin associated protein 12-3	56	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CTCCGTGTGCGTGCCCGTGAG	0.642000													9	138					0	0	0.335167	0	0
SLC7A14	57709	broad.mit.edu	37	3	170244421	170244421	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:170244421C>A	ENST00000231706.4	-	2	620		c.e2+1		CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14							integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GAGACACTTACCTGATAATAT	0.498000													31	67					3.09479e-21	5.68233e-21	0.827153	1	0
CHD8	57680	broad.mit.edu	37	14	21860107	21860107	+	Splice_Site	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:21860107T>A	ENST00000399982.2	-	34	6836		c.e34-2		CHD8_ENST00000557364.1_Splice_Site|CHD8_ENST00000430710.3_Splice_Site	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TCCTTCCTCCTAGGAAGACAA	0.438000													6	30					0	0	0.217242	0	0
RORA	6095	broad.mit.edu	37	15	60803461	60803461	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:60803461C>A	ENST00000335670.6	-	5	884	c.784G>T	c.(784-786)Ggc>Tgc	p.G262C	RP11-219B17.1_ENST00000558235.1_RNA|RORA_ENST00000449337.2_Missense_Mutation_p.G207C|RP11-219B17.1_ENST00000558140.1_RNA|RORA_ENST00000309157.4_Missense_Mutation_p.G287C|RORA_ENST00000261523.5_Missense_Mutation_p.G295C|RP11-219B17.1_ENST00000559902.1_RNA|RP11-219B17.1_ENST00000559824.1_RNA|RP11-219B17.1_ENST00000501579.2_RNA	NM_134261.2	NP_599023.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	295	Hinge.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						GAAGTCTCGCCGTTGGTGAAC	0.473000													23	37					2.52088e-20	4.55744e-20	0.639603	1	0
LCE4A	199834	broad.mit.edu	37	1	152681628	152681628	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152681628C>A	ENST00000368777.1	+	2	333	c.77C>A	c.(76-78)cCc>cAc	p.P26H	LCE4A_ENST00000335535.3_Missense_Mutation_p.P26H			Q5TA78	LCE4A_HUMAN	late cornified envelope 4A	26	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)			CCAAAATGTCCCTCAAAGTGT	0.572000													91	255					8.16033e-55	1.81748e-54	0.870114	1	0
BCAN	63827	broad.mit.edu	37	1	156621456	156621456	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:156621456A>T	ENST00000329117.4	+	7	1608	c.1272A>T	c.(1270-1272)ccA>ccT	p.P424P	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Silent_p.P424P	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	424	Glu-rich.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGAAGACCCAGCAGAGGCCC	0.562000													22	138					0	0	0.681144	0	0
PCID2	55795	broad.mit.edu	37	13	113852580	113852580	+	Splice_Site	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:113852580T>A	ENST00000375457.2	-	3	717		c.e3-2		PCID2_ENST00000337344.4_Splice_Site|PCID2_ENST00000351317.3_Splice_Site|PCID2_ENST00000375479.2_Splice_Site|PCID2_ENST00000246505.5_Splice_Site|PCID2_ENST00000375477.1_Splice_Site|PCID2_ENST00000375459.1_Splice_Site	NM_001258213.1	NP_001245142.1	Q5JVF3	PCID2_HUMAN	PCI domain containing 2						negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)	20	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			AGAGGCCATCTGATTTTAAAA	0.348000													20	454					0	0	0.592651	0	0
POTEE	445582	broad.mit.edu	37	2	132021875	132021875	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:132021875C>A	ENST00000356920.5	+	15	2941	c.2847C>A	c.(2845-2847)acC>acA	p.T949T	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	949	Actin-like.						ATP binding										AGGTCATCACCATCGGCAACG	0.602000													5	90					1.12685e-05	1.30266e-05	0.307466	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121651867	121651867	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:121651867G>T	ENST00000393386.2	+	12	3178	c.2767G>T	c.(2767-2769)Ggg>Tgg	p.G923W	PTPRZ1_ENST00000483028.1_Intron|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	923					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACGTTCTTCAGGGCCTGAACC	0.443000													28	70					1.80694e-10	2.53403e-10	0.740014	1	0
GJB4	127534	broad.mit.edu	37	1	35227407	35227407	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:35227407G>T	ENST00000339480.1	+	2	922	c.552G>T	c.(550-552)aaG>aaT	p.K184N	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	184					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CGGAGAAGAAGGTCTTCACCT	0.572000													11	41					1.08611e-07	1.36452e-07	0.387290	1	0
AMER1	139285	broad.mit.edu	37	X	63410257	63410257	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:63410257T>A	ENST00000330258.3	-	2	3182	c.2910A>T	c.(2908-2910)ccA>ccT	p.P970P	AMER1_ENST00000374869.3_Intron|AMER1_ENST00000403336.1_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									AGGCAGGACCTGGCCCCACTG	0.562000													6	11					0	0	0.248553	0	0
CTNNA3	29119	broad.mit.edu	37	10	68139036	68139036	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:68139036C>A	ENST00000433211.1	-	12	1780	c.1606G>T	c.(1606-1608)Gct>Tct	p.A536S	CTNNA3_ENST00000373744.4_Missense_Mutation_p.A536S	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	536					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						GCACCCGCAGCACGGTCTAAA	0.463000													10	44					2.80697e-09	3.77607e-09	0.387290	1	0
ZNF804B	219578	broad.mit.edu	37	7	88964844	88964844	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:88964844C>A	ENST00000333190.4	+	4	3157	c.2548C>A	c.(2548-2550)Cag>Aag	p.Q850K		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	850						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCAGGGAACTCAGCACGACAG	0.383000										HNSCC(36;0.09)			17	69					1.50039e-11	2.18049e-11	0.608945	1	0
ARHGEF3	50650	broad.mit.edu	37	3	56779345	56779345	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:56779345C>A	ENST00000413728.2	-	7	1319	c.776G>T	c.(775-777)tGg>tTg	p.W259L	ARHGEF3_ENST00000296315.3_Missense_Mutation_p.W253L|ARHGEF3_ENST00000338458.4_Missense_Mutation_p.W285L|ARHGEF3_ENST00000497267.1_Missense_Mutation_p.W224L|ARHGEF3_ENST00000495373.1_Missense_Mutation_p.W253L|ARHGEF3_ENST00000496106.1_Missense_Mutation_p.W259L	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	253	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GAGGAAATTCCAGAGATCTAG	0.483000													36	136					1.23103e-26	2.40831e-26	0.864702	1	0
GPR112	139378	broad.mit.edu	37	X	135496331	135496331	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:135496331G>T	ENST00000394143.1	+	25	9341	c.9050G>T	c.(9049-9051)cGg>cTg	p.R3017L	GPR112_ENST00000370652.1_Missense_Mutation_p.R3017L|GPR112_ENST00000412101.1_Missense_Mutation_p.R2812L|GPR112_ENST00000287534.4_Missense_Mutation_p.R2736L|GPR112_ENST00000394141.1_Missense_Mutation_p.R2812L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	3017					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGGAGCAGCCGGTGTCAGATA	0.353000													23	106					1.08971e-26	2.13629e-26	0.706142	1	0
GPI	2821	broad.mit.edu	37	19	34857298	34857298	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:34857298G>C	ENST00000415930.3	+	3	458	c.288G>C	c.(286-288)aaG>aaC	p.K96N	GPI_ENST00000586425.1_Missense_Mutation_p.K57N|GPI_ENST00000356487.5_Missense_Mutation_p.K57N	NM_001184722.1	NP_001171651.1	P06744	G6PI_HUMAN	glucose-6-phosphate isomerase	57					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	25	Esophageal squamous(110;0.162)					ATTACTCCAAGAACCTGGTGA	0.562000													28	400					0	0	0.788014	0	0
GPR158	57512	broad.mit.edu	37	10	25887511	25887511	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:25887511G>T	ENST00000376351.3	+	11	3315	c.2956G>T	c.(2956-2958)Gcc>Tcc	p.A986S	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	986						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCCCACCACTGCCAATTCTGA	0.517000													4	71					0.014758	0.0152943	0.184627	1	0
TRPC3	7222	broad.mit.edu	37	4	122853735	122853735	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:122853735G>A	ENST00000264811.5	-	1	877	c.459C>T	c.(457-459)gaC>gaT	p.D153D	TRPC3_ENST00000513531.1_Silent_p.D153D|TRPC3_ENST00000379645.3_Silent_p.D226D	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	141					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AGCGCGTGCCGTCCTCGTCGT	0.622000													29	31					0	0	0.740014	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178080913	178080913	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:178080913G>T	ENST00000411529.2	+	4	535	c.484G>T	c.(484-486)Gtt>Ttt	p.V162F	HNRNPA3_ENST00000435711.1_Missense_Mutation_p.V184F|HNRNPA3_ENST00000392524.2_Missense_Mutation_p.V184F	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	184	RRM 2.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						TGATAAAATTGTTGGTAAGTA	0.313000													24	27					2.41591e-17	4.08146e-17	0.681144	1	0
SLITRK3	22865	broad.mit.edu	37	3	164907904	164907904	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:164907904C>T	ENST00000475390.1	-	2	1158	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E239K			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	239	LRRCT 1.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TGTACAATTTCACATGTACAG	0.458000										HNSCC(40;0.11)			25	69					0	0	0.654019	0	0
HEATR1	55127	broad.mit.edu	37	1	236721634	236721634	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:236721634C>G	ENST00000366582.3	-	36	5221	c.5107G>C	c.(5107-5109)Gag>Cag	p.E1703Q	HEATR1_ENST00000366581.2_Missense_Mutation_p.E1622Q	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1703					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TCCTTTCTCTCTGGAGCAATC	0.507000													7	83					0	0	0.457914	0	0
NID2	22795	broad.mit.edu	37	14	52520599	52520599	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:52520599C>A	ENST00000216286.5	-	5	1126	c.1127G>T	c.(1126-1128)gGc>gTc	p.G376V	NID2_ENST00000541773.1_Missense_Mutation_p.G323V	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	376						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TAAATCTGGGCCCCCTACCTC	0.507000													28	30					7.26314e-15	1.15061e-14	0.717897	1	0
MYH14	79784	broad.mit.edu	37	19	50779294	50779294	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:50779294C>T	ENST00000440075.2	+	28	3561	c.3514C>T	c.(3514-3516)Cgg>Tgg	p.R1172W	MYH14_ENST00000425460.1_Missense_Mutation_p.R1139W|MYH14_ENST00000596571.1_Missense_Mutation_p.R1131W|MYH14_ENST00000601313.1_Missense_Mutation_p.R1172W|MYH14_ENST00000598205.1_Missense_Mutation_p.R1139W|MYH14_ENST00000376970.2_Missense_Mutation_p.R1164W|MYH14_ENST00000262269.8_Missense_Mutation_p.R1172W			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1131					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.R1172W(1)|p.R1131W(1)		central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GAAATCCCTGCGGGAGGCTCA	0.677000													25	4					0	0	0.740014	0	0
LRRC32	2615	broad.mit.edu	37	11	76372411	76372411	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:76372411G>T	ENST00000407242.2	-	3	468	c.226C>A	c.(226-228)Cgt>Agt	p.R76S	LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000260061.5_Missense_Mutation_p.R76S|LRRC32_ENST00000404995.1_Missense_Mutation_p.R76S|AP001189.4_ENST00000447519.1_RNA	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	76						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						TCCAGGTGACGAAGTGCTGTG	0.622000													32	44					1.49673e-21	2.76162e-21	0.819951	1	0
CSPG4	1464	broad.mit.edu	37	15	75968663	75968663	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:75968663G>T	ENST00000308508.5	-	10	6289	c.6197C>A	c.(6196-6198)aCc>aAc	p.T2066N	CTD-2026K11.1_ENST00000569467.1_RNA	NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	2066	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						ATCTAGGACGGTGGGGTCCAG	0.692000													3	11					0.00909568	0.00946796	0.150653	1	0
GUCY2F	2986	broad.mit.edu	37	X	108673536	108673536	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:108673536C>A	ENST00000218006.2	-	8	2082	c.1791_splice	c.e8+1	p.M597_splice		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	597	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						TTTCTCATACCATTTCGAACA	0.378000													87	156					1.85599e-38	3.96928e-38	0.870114	1	0
KCNH2	3757	broad.mit.edu	37	7	150649546	150649546	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:150649546G>T	ENST00000392968.2	-	4	2356	c.1236C>A	c.(1234-1236)ttC>ttA	p.F412L	KCNH2_ENST00000430723.3_Missense_Mutation_p.F508L|KCNH2_ENST00000262186.5_Missense_Mutation_p.F508L|KCNH2_ENST00000330883.4_Missense_Mutation_p.F168L			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	508					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGAGCAGGTCGAAGGGGATGG	0.627000													13	33					2.27111e-07	2.82127e-07	0.411799	1	0
OPN1LW	5956	broad.mit.edu	37	X	153420200	153420200	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153420200C>G	ENST00000369951.4	+	4	790	c.730C>G	c.(730-732)Ctg>Gtg	p.L244V	OPN1LW_ENST00000463296.1_Intron	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	244					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAAGTGTGGCTGGCCATCCG	0.587000													53	523					0	0	0.870114	0	0
VAX2	25806	broad.mit.edu	37	2	71160101	71160101	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:71160101C>T	ENST00000234392.2	+	3	672	c.640C>T	c.(640-642)Cac>Tac	p.H214Y		NM_012476.2	NP_036608.1	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	214					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	7						ACCTGCCAGCCACAGGGGCAC	0.706000													9	58					0	0	0.411799	0	0
FGF14	2259	broad.mit.edu	37	13	102568883	102568883	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:102568883C>A	ENST00000376143.4	-	1	112	c.113G>T	c.(112-114)gGg>gTg	p.G38V	FGF14_ENST00000376131.4_Intron	NM_004115.3	NP_004106.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	38					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTTGCAGAGCCCGCGGTTCTT	0.657000													10	131					4.68919e-08	5.99121e-08	0.361761	1	0
PGLYRP4	57115	broad.mit.edu	37	1	153315566	153315566	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:153315566C>A	ENST00000368739.3	-	5	818	c.460_splice	c.e5+1	p.G154_splice	PGLYRP4_ENST00000359650.5_Splice_Site_p.G158_splice			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	158					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TAACTGTTACCTTTCTTAGTG	0.478000													21	43					7.41877e-09	9.78515e-09	0.608945	1	0
EFHB	151651	broad.mit.edu	37	3	19921297	19921297	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:19921297C>A	ENST00000295824.9	-	13	2490		c.e13-1		EFHB_ENST00000344838.4_Splice_Site	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B						signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TCTCTGCAATCTAGAAAAAGG	0.279000													8	28					1.12685e-05	1.30266e-05	0.307466	1	0
VIT	5212	broad.mit.edu	37	2	37035700	37035700	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:37035700G>T	ENST00000379242.3	+	15	1777	c.1475G>T	c.(1474-1476)cGg>cTg	p.R492L	VIT_ENST00000497382.1_Missense_Mutation_p.R146L|VIT_ENST00000389975.3_Missense_Mutation_p.R477L|VIT_ENST00000379241.3_Missense_Mutation_p.R455L|VIT_ENST00000404084.1_Missense_Mutation_p.R429L|VIT_ENST00000401530.1_Missense_Mutation_p.R456L	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	477						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CTGGTGAAGCGGGTCTGCGAC	0.612000													28	60					1.30897e-18	2.27889e-18	0.740014	1	0
HSP90B1	7184	broad.mit.edu	37	12	104331491	104331491	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:104331491A>T	ENST00000299767.5	+	6	944	c.762A>T	c.(760-762)gaA>gaT	p.E254D		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	254					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	TAAAAGAAGAAGCATCTGATT	0.303000													10	25					0	0	0.361761	0	0
GNPAT	8443	broad.mit.edu	37	1	231408087	231408087	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:231408087C>T	ENST00000366647.4	+	11	1721	c.1552C>T	c.(1552-1554)Cgt>Tgt	p.R518C	GNPAT_ENST00000366646.3_Missense_Mutation_p.R457C	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	518					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TCGCTTCCTACGTGATGTTTT	0.388000													28	235					0	0	0.760397	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455293	187455293	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:187455293G>T	ENST00000307161.5	-	2	804	c.603C>A	c.(601-603)atC>atA	p.I201I	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	201					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	AGATGACTATGATCATGGGGA	0.537000													9	100					4.68919e-08	5.99121e-08	0.361761	1	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	99025670	99025670	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:99025670C>A	ENST00000453547.2	-	2	268	c.269G>T	c.(268-270)gGg>gTg	p.G90V	ARHGAP19_ENST00000358531.4_Missense_Mutation_p.G90V|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.G90V|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.G81V|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.G90V|ARHGAP19_ENST00000371027.1_Missense_Mutation_p.G81V																							TGGGCCAGCCCCGCCAGGCAA	0.547000													18	27					1.50039e-11	2.18049e-11	0.608945	1	0
CCDC129	223075	broad.mit.edu	37	7	31594513	31594513	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:31594513C>A	ENST00000319386.3	+	4	1247	c.254C>A	c.(253-255)aCt>aAt	p.T85N	CCDC129_ENST00000482748.1_3'UTR|CCDC129_ENST00000409210.1_5'UTR|CCDC129_ENST00000407970.3_Missense_Mutation_p.T85N|CCDC129_ENST00000451887.2_Missense_Mutation_p.T111N			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	85										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						ATTGACCGCACTGGTAAGACA	0.328000													5	9					0.00198382	0.00212133	0.248553	1	0
TIA1	7072	broad.mit.edu	37	2	70454899	70454899	+	Silent	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:70454899T>A	ENST00000433529.2	-	6	576	c.366A>T	c.(364-366)atA>atT	p.I122I	TIA1_ENST00000445587.1_Silent_p.I111I|TIA1_ENST00000282574.4_Silent_p.I122I|TIA1_ENST00000415783.2_Silent_p.I111I|TIA1_ENST00000416149.2_Silent_p.I122I|C2orf42_ENST00000470096.1_Intron	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	122	RRM 2.				apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						AAGCAGCTTTTATATCTTCAG	0.308000													23	135					0	0	0.693898	0	0
NUP205	23165	broad.mit.edu	37	7	135312828	135312828	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:135312828G>T	ENST00000285968.6	+	34	4927	c.4901G>T	c.(4900-4902)aGt>aTt	p.S1634I		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1634					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						CTCACATCTAGTATGGCCCAG	0.507000													20	157					8.10497e-08	1.02579e-07	0.592651	1	0
BAGE2	85319	broad.mit.edu	37	21	11097589	11097589	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:11097589G>T	ENST00000470054.1	-	0	280									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ctcaccacaggggactcctcc	0.537000													4	108					4.096e-09	5.49051e-09	0.217242	1	0
TBX18	9096	broad.mit.edu	37	6	85446745	85446745	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:85446745G>T	ENST00000369663.5	-	8	1819	c.1482C>A	c.(1480-1482)ccC>ccA	p.P494P	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	494					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		ACTGGAGCTGGGGGGACATTC	0.537000													65	74					1.8615e-32	3.82461e-32	0.870114	1	0
FCRL1	115350	broad.mit.edu	37	1	157771805	157771805	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:157771805G>T	ENST00000358292.3	-	5	837	c.786C>A	c.(784-786)ttC>ttA	p.F262L	FCRL1_ENST00000368176.3_Missense_Mutation_p.F262L|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.F262L	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	262	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGGAAAGGTTGAAGGAGGCTC	0.582000													44	38					1.23103e-26	2.40831e-26	0.864702	1	0
WDR52	55779	broad.mit.edu	37	3	113082370	113082370	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:113082370C>G	ENST00000393845.2	-	20	2791	c.2725G>C	c.(2725-2727)Gaa>Caa	p.E909Q	WDR52_ENST00000295868.2_Missense_Mutation_p.E909Q	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	909										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						GGCTCTGTTTCAATTCCAAAC	0.333000													4	27					0	0	0.184627	0	0
THBS2	7058	broad.mit.edu	37	6	169620428	169620428	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:169620428A>T	ENST00000366787.3	-	22	3625	c.3376T>A	c.(3376-3378)Tta>Ata	p.L1126I	XXyac-YX65C7_A.2_ENST00000444188.1_RNA|THBS2_ENST00000488355.1_5'UTR	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	1126	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TCATGCACTAAGACTCTAAAA	0.453000													16	68					0	0	0.575678	0	0
SPAST	6683	broad.mit.edu	37	2	32339791	32339791	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:32339791G>T	ENST00000315285.3	+	5	892	c.767G>T	c.(766-768)gGa>gTa	p.G256V	SPAST_ENST00000345662.1_Missense_Mutation_p.G224V	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	256	Required for interaction with RTN1.|Sufficient for interaction with microtubules.|Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATGAAAACTGGATCTGCAGGC	0.443000													18	29					2.4624e-09	3.32203e-09	0.575678	1	0
PTTG1IP	754	broad.mit.edu	37	21	46281178	46281178	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:46281178C>G	ENST00000330938.3	-	3	397	c.177G>C	c.(175-177)tgG>tgC	p.W59C	PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397886.3_Missense_Mutation_p.W38C|PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000397887.3_Missense_Mutation_p.W59C	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	59	PSI.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TAGTGTTGCACCAAAGACACT	0.502000													16	24					0	0	0.500413	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808834	18808834	+	Silent	SNP	G	G	T	rs145229956	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:18808834G>T	ENST00000400664.1	+	1	1411	c.1359G>T	c.(1357-1359)gcG>gcT	p.A453A		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	453						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGAAAGAGGCGGCCTACAAGG	0.632000													25	69					3.73148e-12	5.55589e-12	0.717897	1	0
COL8A2	1296	broad.mit.edu	37	1	36564489	36564489	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:36564489C>A	ENST00000397799.1	-	4	1017	c.793G>T	c.(793-795)Gag>Tag	p.E265*	COL8A2_ENST00000303143.4_Nonsense_Mutation_p.E265*|COL8A2_ENST00000481785.1_Nonsense_Mutation_p.E200*			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	265	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCTCCTGGCTCCCCCCTGGGG	0.657000													11	21					9.05144e-12	1.33189e-11	0.435327	1	0
HTR1F	3355	broad.mit.edu	37	3	88040761	88040761	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:88040761G>T	ENST00000319595.4	+	1	916	c.862G>T	c.(862-864)Gaa>Taa	p.E288*		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	288					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	AGGTACAAGAGAACGGAAAGC	0.378000													3	15					2.56e-06	3.05318e-06	0.150653	1	0
COCH	1690	broad.mit.edu	37	14	31348034	31348034	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:31348034C>T	ENST00000396618.3	+	5	313	c.257C>T	c.(256-258)tCa>tTa	p.S86L	COCH_ENST00000475087.1_Missense_Mutation_p.S86L|COCH_ENST00000460581.2_5'UTR|COCH_ENST00000216361.4_Missense_Mutation_p.S86L|RP11-829H16.3_ENST00000555108.1_RNA	NM_004086.2	NP_004077.1	O43405	COCH_HUMAN	cochlin	86	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		ATCAGCAACTCAGGGGGACCT	0.458000													10	52					0	0	0.435327	0	0
RPL10	6134	broad.mit.edu	37	X	153627911	153627911	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153627911G>A	ENST00000424325.2	+	4	354	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	RPL10_ENST00000369817.2_Missense_Mutation_p.E56K|RPL10_ENST00000406022.2_Missense_Mutation_p.E5K	NM_001256577.1|NM_001256580.1|NM_006013.3	NP_001243506.1|NP_001243509.1|NP_006004.2	P27635	RL10_HUMAN	ribosomal protein L10	56					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome			large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTGTCAGATGAATATGAGCA	0.507000													12	143					0	0	0.520397	0	0
TBX18	9096	broad.mit.edu	37	6	85457652	85457652	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:85457652A>T	ENST00000369663.5	-	5	1262	c.925T>A	c.(925-927)Tat>Aat	p.Y309N	TBX18_ENST00000606784.1_Missense_Mutation_p.Y151N|TBX18_ENST00000606521.1_5'UTR	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	309					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TGATTCTGATAGGCAGTGACG	0.423000													19	9					0	0	0.639603	0	0
IRS1	3667	broad.mit.edu	37	2	227662050	227662050	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:227662050C>A	ENST00000305123.4	-	1	2425	c.1405G>T	c.(1405-1407)Ggt>Tgt	p.G469C		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	469					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CCCTTGCCACCCATGCAGATA	0.632000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	72	51					2.98122e-55	6.65559e-55	0.870114	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55063071	55063071	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:55063071C>T	ENST00000526016.1	-	0	566					NR_038174.2																						CCTCCTTTCACAGCCTCTCCA	0.413000													19	21					0	0	0.539581	0	0
KIF21B	23046	broad.mit.edu	37	1	200948800	200948800	+	Silent	SNP	G	G	T	rs144601295		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:200948800G>T	ENST00000332129.2	-	29	4300	c.3984C>A	c.(3982-3984)atC>atA	p.I1328I	KIF21B_ENST00000422435.2_Silent_p.I1341I|KIF21B_ENST00000360529.5_Silent_p.I1328I|KIF21B_ENST00000461742.2_Silent_p.I1341I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1341					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TTAGAGCTGCGATCTCCTGTC	0.587000											OREG0014066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	107	300					5.78508e-65	1.3039e-64	0.870114	1	0
RGP1	9827	broad.mit.edu	37	9	35751401	35751401	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:35751401G>A	ENST00000378078.4	+	6	767	c.626G>A	c.(625-627)cGc>cAc	p.R209H	RGP1_ENST00000456972.2_Missense_Mutation_p.R249H	NM_001080496.2	NP_001073965.2	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	209										cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACATCCTGCCGCAGCCTCCGT	0.532000													5	81					0	0	0.184627	0	0
SEC11C	90701	broad.mit.edu	37	18	56807241	56807241	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:56807241G>C	ENST00000587834.1	+	1	533	c.61G>C	c.(61-63)Gac>Cac	p.D21H	SEC11C_ENST00000592774.1_3'UTR|SEC11C_ENST00000588875.1_Missense_Mutation_p.D21H	NM_033280.2	NP_150596.1	Q9BY50	SC11C_HUMAN	SEC11 homolog C (S. cerevisiae)	21					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity			endometrium(1)|large_intestine(4)|liver(2)|lung(2)	9		Colorectal(73;0.175)				TATCTTCGGGGACCTGAAGAA	0.701000													3	10					0	0	0.150653	0	0
SRPX2	27286	broad.mit.edu	37	X	99925897	99925897	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:99925897C>A	ENST00000373004.3	+	11	1739	c.1311C>A	c.(1309-1311)ccC>ccA	p.P437P		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	437					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						CTGTCACCCCCGAGGAAATCT	0.512000											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	43					0.00185496	0.00199033	0.435327	1	0
MUC16	94025	broad.mit.edu	37	19	9061255	9061255	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:9061255C>A	ENST00000397910.4	-	3	26394	c.26191G>T	c.(26191-26193)Gga>Tga	p.G8731*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8733	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGGCATTCCAGAAAGAGAA	0.498000													18	29					1.28384e-07	1.60437e-07	0.608945	1	0
OTOGL	283310	broad.mit.edu	37	12	80714282	80714282	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:80714282G>T	ENST00000458043.2	+	33	3862	c.3856G>T	c.(3856-3858)Gag>Tag	p.E1286*	OTOGL_ENST00000547103.1_Nonsense_Mutation_p.E1286*	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCTTAGCTTGGAGCTGTGGGA	0.438000													15	19					3.32936e-07	4.09265e-07	0.539581	1	0
OR10G7	390265	broad.mit.edu	37	11	123909279	123909279	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:123909279C>G	ENST00000330487.5	-	1	438	c.430G>C	c.(430-432)Gcc>Ccc	p.A144P		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GTGCCGGTGGCCAGGAGGGCA	0.547000													76	122					0	0	0.870114	0	0
KLF3	51274	broad.mit.edu	37	4	38696400	38696400	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:38696400G>T	ENST00000261438.5	+	5	1034	c.729G>T	c.(727-729)aaG>aaT	p.K243N		NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	243	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						AGCCTGGGAAGAGACCTTTAC	0.468000													341	85					8.75363e-181	2.01398e-180	0.870114	1	0
TRMT2B	79979	broad.mit.edu	37	X	100274025	100274025	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:100274025C>G	ENST00000338687.7	-	12	1993	c.1188G>C	c.(1186-1188)agG>agC	p.R396S	TRMT2B_ENST00000372939.1_Missense_Mutation_p.R396S|TRMT2B_ENST00000545398.1_Missense_Mutation_p.R441S|TRMT2B_ENST00000372931.5_Missense_Mutation_p.R441S|TRMT2B_ENST00000372935.1_Missense_Mutation_p.R441S|TRMT2B_ENST00000372936.3_Missense_Mutation_p.R441S			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	441							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						TGTGGATGGCCCTGAAGTTTC	0.383000													11	34					0	0	0.411799	0	0
RHO	6010	broad.mit.edu	37	3	129247931	129247931	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:129247931C>A	ENST00000296271.3	+	1	449	c.355C>A	c.(355-357)Ctg>Atg	p.L119M		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	119	Retinal chromophore binding (By similarity).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CTTTGCCACCCTGGGCGGTAT	0.632000													52	75					8.33888e-18	1.42671e-17	0.870114	1	0
RDH12	145226	broad.mit.edu	37	14	68193818	68193818	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:68193818G>T	ENST00000551171.1	+	7	893	c.569G>T	c.(568-570)aGc>aTc	p.S190I	RDH12_ENST00000267502.3_Missense_Mutation_p.S190I|RDH12_ENST00000539142.1_Missense_Mutation_p.S190I	NM_152443.2	NP_689656.2	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12 (all-trans/9-cis/11-cis)	190					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(4)	12				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	GACCTCCAGAGCGAGAAGCGC	0.567000													17	46					3.52763e-06	4.165e-06	0.520397	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130319491	130319491	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:130319491G>T	ENST00000299164.2	+	1	623	c.623G>T	c.(622-624)gGg>gTg	p.G208V		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	208					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CGCAGGTCTGGGCGCGCCAAG	0.677000													3	6					0.150653	0.152846	0.150653	1	0
EPS8L2	64787	broad.mit.edu	37	11	721612	721612	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:721612G>T	ENST00000533256.1	+	11	1191	c.816G>T	c.(814-816)cgG>cgT	p.R272R	EPS8L2_ENST00000530636.1_Silent_p.R272R|EPS8L2_ENST00000526198.1_Silent_p.R288R|AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Silent_p.R272R			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	272						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGTGGCCCGGCTGCAGAAGG	0.652000													3	24					0.004672	0.00492037	0.115264	1	0
KIF21B	23046	broad.mit.edu	37	1	200974497	200974497	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:200974497C>A	ENST00000332129.2	-	5	987	c.671G>T	c.(670-672)cGc>cTc	p.R224L	KIF21B_ENST00000422435.2_Missense_Mutation_p.R224L|KIF21B_ENST00000360529.5_Missense_Mutation_p.R224L|KIF21B_ENST00000461742.2_Missense_Mutation_p.R224L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	224	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GGCGTGGGAGCGTGAGCTCTG	0.642000													31	104					5.71845e-15	9.10501e-15	0.812448	1	0
KIFC2	90990	broad.mit.edu	37	8	145692683	145692683	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:145692683G>A	ENST00000301332.2	+	4	805	c.428G>A	c.(427-429)gGg>gAg	p.G143E		NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	143					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTGCTCCAGGGGACTCAGCCA	0.617000											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	121					0	0	0.639603	0	0
SPTA1	6708	broad.mit.edu	37	1	158637796	158637796	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158637796C>T	ENST00000368148.3	-	15	2070	c.1890G>A	c.(1888-1890)ttG>ttA	p.L630L	SPTA1_ENST00000368147.3_Silent_p.L630L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	630					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TATTAACTGCCAACTCCTTTT	0.408000													32	483					0	0	0.870114	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559459	129559459	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:129559459G>T	ENST00000422113.2	-	9	2587	c.2261C>A	c.(2260-2262)cCt>cAt	p.P754H	TMEM132D_ENST00000389441.4_Missense_Mutation_p.P292H	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	754						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGCAATGATAGGCCACTTGAA	0.478000													17	46					1.02788e-11	1.5066e-11	0.520397	1	0
MAST1	22983	broad.mit.edu	37	19	12958701	12958701	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:12958701C>A	ENST00000251472.4	+	7	643	c.604C>A	c.(604-606)Cgc>Agc	p.R202S	MAST1_ENST00000591495.1_Missense_Mutation_p.R198S	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	202					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CGACTTTACCCGCGCCTACGA	0.687000											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	6					9.31168e-06	1.08377e-05	0.435327	1	0
PXDNL	137902	broad.mit.edu	37	8	52387649	52387649	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:52387649C>A	ENST00000356297.4	-	7	677	c.577G>T	c.(577-579)Gag>Tag	p.E193*	PXDNL_ENST00000543296.1_Nonsense_Mutation_p.E193*	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	193	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGTAAAAGCTCCCCCAGCCAC	0.522000													4	18					0.184627	0.18651	0.184627	1	0
LILRB2	10288	broad.mit.edu	37	19	54783382	54783382	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:54783382C>A	ENST00000391748.1	-	5	603	c.476G>T	c.(475-477)gGa>gTa	p.G159V	LILRB2_ENST00000434421.1_Missense_Mutation_p.G43V|LILRB2_ENST00000314446.5_Missense_Mutation_p.G159V|LILRB2_ENST00000391746.1_Missense_Mutation_p.G159V|LILRB2_ENST00000391749.4_Missense_Mutation_p.G159V	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	159	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTCTTCTTCTCCTTCCTTACA	0.622000													172	39					3.43953e-78	7.82732e-78	0.870114	1	0
NPAP1	23742	broad.mit.edu	37	15	24923443	24923443	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:24923443C>A	ENST00000329468.2	+	1	2903	c.2429C>A	c.(2428-2430)gCc>gAc	p.A810D		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTGAGCAGTGCCTCTGCAGCA	0.527000													58	51					1.08241e-25	2.09362e-25	0.870114	1	0
PCSK4	54760	broad.mit.edu	37	19	1487140	1487140	+	Splice_Site	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:1487140C>T	ENST00000300954.5	-	7	916	c.855_splice	c.e7+1	p.K285_splice		NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	285	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCACTCACCTTGGTCACAC	0.741000													11	22					0	0	0.457914	0	0
WNT2	7472	broad.mit.edu	37	7	116960808	116960808	+	Silent	SNP	G	G	A	rs140391205		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:116960808G>A	ENST00000265441.3	-	2	422	c.123C>T	c.(121-123)tgC>tgT	p.C41C	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	41					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GCACATTATCGCACATCACCC	0.597000													13	35					0	0	0.539581	0	0
PLXNB3	5365	broad.mit.edu	37	X	153032460	153032460	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153032460G>T	ENST00000538966.1	+	4	518	c.247G>T	c.(247-249)Gca>Tca	p.A83S	PLXNB3_ENST00000361971.5_Missense_Mutation_p.A60S|PLXNB3_ENST00000538282.1_Intron|PLXNB3_ENST00000538776.1_Intron|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	60	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTGGCACTGGCACCTGGCCG	0.642000													9	102					6.81908e-15	1.08483e-14	0.457914	1	0
DIDO1	11083	broad.mit.edu	37	20	61511721	61511721	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:61511721C>A	ENST00000266070.4	-	16	5912	c.5587G>T	c.(5587-5589)Gtg>Ttg	p.V1863L	DIDO1_ENST00000395343.1_Missense_Mutation_p.V1863L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1863	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCGCCCGTCACCTCGTTATAC	0.607000													31	84					3.11337e-16	5.11735e-16	0.769981	1	0
RREB1	6239	broad.mit.edu	37	6	7231817	7231817	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:7231817G>T	ENST00000379938.2	+	10	4022	c.3485G>T	c.(3484-3486)cGa>cTa	p.R1162L	RREB1_ENST00000349384.6_Missense_Mutation_p.R1162L|RREB1_ENST00000334984.6_Missense_Mutation_p.R1162L|RREB1_ENST00000379933.3_Missense_Mutation_p.R1162L	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1162					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATGAGGAGCCGACCCCGCGCC	0.677000													3	11					0.004672	0.00492037	0.115264	1	0
CCT6B	10693	broad.mit.edu	37	17	33281456	33281456	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:33281456C>A	ENST00000314144.5	-	4	614	c.499G>T	c.(499-501)Gtc>Ttc	p.V167F	CCT6B_ENST00000421975.3_Missense_Mutation_p.V167F|CCT6B_ENST00000436961.3_Missense_Mutation_p.V122F	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	167					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TCTGTTAAGACATCAGCCAGT	0.313000													10	19					0.000219431	0.000242496	0.457914	1	0
CCDC77	84318	broad.mit.edu	37	12	537935	537935	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:537935G>T	ENST00000239830.4	+	6	593	c.413_splice	c.e6-1	p.R138_splice	CCDC77_ENST00000540180.1_Splice_Site_p.R106_splice|CCDC77_ENST00000412006.2_Splice_Site_p.R106_splice|CCDC77_ENST00000540344.1_3'UTR|CCDC77_ENST00000422000.1_Splice_Site_p.R106_splice	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	138						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AGAATTGCAGGGAGCTAGAAG	0.363000													9	31					3.86212e-05	4.36547e-05	0.361761	1	0
CD248	57124	broad.mit.edu	37	11	66083347	66083347	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:66083347G>T	ENST00000311330.3	-	1	1168	c.1152C>A	c.(1150-1152)gcC>gcA	p.A384A	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	384						integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CACCGTTGAAGGCCTTCCAGG	0.627000													28	46					3.11337e-16	5.11735e-16	0.769981	1	0
SSMEM1	136263	broad.mit.edu	37	7	129855931	129855931	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:129855931T>G	ENST00000297819.3	+	3	407	c.356T>G	c.(355-357)tTg>tGg	p.L119W		NM_145268.3	NP_660311.1			serine-rich single-pass membrane protein 1																		GAAGTGGCTTTGGTCAATGCC	0.483000													39	34					0	0	0.859065	0	0
DCX	1641	broad.mit.edu	37	X	110574138	110574138	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:110574138G>T	ENST00000356915.2	-	5	1002	c.940C>A	c.(940-942)Caa>Aaa	p.Q314K	DCX_ENST00000496551.1_5'UTR|DCX_ENST00000488120.1_Intron|DCX_ENST00000338081.3_Intron|DCX_ENST00000356220.3_Missense_Mutation_p.Q314K|DCX_ENST00000371993.2_Intron	NM_001195553.1|NM_178152.2|NM_178153.2	NP_001182482.1|NP_835365.1|NP_835366.1	O43602	DCX_HUMAN	doublecortin	391	Doublecortin 2.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						TCACCGTCTTGGTCGTTACCT	0.517000													39	128					1.00953e-15	1.64212e-15	0.864702	1	0
FAM110C	642273	broad.mit.edu	37	2	45600	45600	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:45600C>T	ENST00000327669.4	-	1	785	c.786G>A	c.(784-786)cgG>cgA	p.R262R		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	262						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CGCCGCTGTGCCGGGAGAAGC	0.672000													3	7					0	0	0.248553	0	0
ULK3	25989	broad.mit.edu	37	15	75131080	75131080	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:75131080G>A	ENST00000440863.2	-	10	1097	c.1006C>T	c.(1006-1008)Cag>Tag	p.Q336*	ULK3_ENST00000568667.1_Nonsense_Mutation_p.Q347*|ULK3_ENST00000569437.1_Nonsense_Mutation_p.Q336*	NM_001099436.1	NP_001092906.1	Q6PHR2	ULK3_HUMAN	unc-51 like kinase 3	336	MIT 1.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						GACACGTACTGCCCCACCTGT	0.607000													10	3					0	0	0.387290	0	0
PRRC2C	23215	broad.mit.edu	37	1	171504727	171504727	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:171504727G>C	ENST00000367742.3	+	13	2276	c.2034G>C	c.(2032-2034)caG>caC	p.Q678H	PRRC2C_ENST00000426496.2_Missense_Mutation_p.Q676H|PRRC2C_ENST00000392078.3_Missense_Mutation_p.Q678H|PRRC2C_ENST00000338920.4_Missense_Mutation_p.Q676H			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	676	Gln-rich.						protein C-terminus binding										CACGATTCCAGCGGCAGCAGG	0.393000													17	195					0	0	0.639603	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56703266	56703266	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:56703266G>T	ENST00000586855.2	-	3	854	c.541C>A	c.(541-543)Cga>Aga	p.R181R	ZSCAN5B_ENST00000358992.3_Silent_p.R181R			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	181					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TGCTGCTCTCGGCGGGCCTGG	0.647000													66	56					3.83446e-41	8.28524e-41	0.870114	1	0
TAF3	83860	broad.mit.edu	37	10	8006719	8006719	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:8006719G>T	ENST00000344293.5	+	3	1452	c.1246G>T	c.(1246-1248)Gaa>Taa	p.E416*		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	416					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						ATCGGAATCTGAAGGAGACAT	0.473000													29	76					4.14481e-20	7.45036e-20	0.819951	1	0
PRDM8	56978	broad.mit.edu	37	4	81124650	81124650	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:81124650C>A	ENST00000339711.4	+	10	3265	c.2034C>A	c.(2032-2034)cgC>cgA	p.R678R	PRDM8_ENST00000415738.2_Silent_p.R678R|PRDM8_ENST00000504452.1_Silent_p.R678R	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	678					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						TCAGGGAGCGCCACCACCTCT	0.572000													3	9					0.004672	0.00492037	0.115264	1	0
OR5M11	219487	broad.mit.edu	37	11	56309923	56309923	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:56309923T>C	ENST00000528616.2	-	1	834	c.811A>G	c.(811-813)Aaa>Gaa	p.K271E		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						GCTATTATTTTAGATTCCTCA	0.413000													27	41					0	0	0.706142	0	0
ZFP57	346171	broad.mit.edu	37	6	29640988	29640988	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:29640988G>T	ENST00000376883.1	-	6	1251	c.840C>A	c.(838-840)acC>acA	p.T280T	ZFP57_ENST00000488757.1_Silent_p.T300T|ZFP57_ENST00000376881.3_Silent_p.T280T			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	216					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						ATTCAGCCTGGGTGCCTGGAA	0.557000													37	148					1.57019e-19	2.79047e-19	0.834066	1	0
BAGE2	85319	broad.mit.edu	37	21	11098839	11098839	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:11098839C>T	ENST00000470054.1	-	0	86									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agacgagccacggtgttacag	0.617000													3	27					0	0	0.115264	0	0
MLLT6	4302	broad.mit.edu	37	17	36868120	36868120	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:36868120C>T	ENST00000325718.7	+	7	664	c.573C>T	c.(571-573)agC>agT	p.S191S	MLLT6_ENST00000378137.5_Silent_p.S191S	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	191	Gly/Ser-rich.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					GGCACAGCAGCGGGGGAGGCG	0.602000			T	MLL	AL								3	10					0	0	0.150653	0	0
COL5A2	1290	broad.mit.edu	37	2	189923234	189923234	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:189923234C>A	ENST00000374866.3	-	33	2424	c.2150G>T	c.(2149-2151)gGg>gTg	p.G717V		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	717					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCTCTTTCCCCAGGATTTCC	0.438000													10	35					0.00621372	0.00653308	0.335167	1	0
IGSF10	285313	broad.mit.edu	37	3	151166556	151166556	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:151166556T>C	ENST00000282466.3	-	4	1212	c.1213A>G	c.(1213-1215)Aaa>Gaa	p.K405E		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	405					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCCACCTGTTTATATTTGTAA	0.433000													51	38					0	0	0.870114	0	0
PAPSS1	9061	broad.mit.edu	37	4	108566003	108566003	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:108566003C>A	ENST00000265174.4	-	10	1733	c.1461G>T	c.(1459-1461)gtG>gtT	p.V487V		NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	487					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		AGATGGCCACCACTGTCGTCT	0.488000													19	16					3.62473e-10	5.01968e-10	0.608945	1	0
DUSP26	78986	broad.mit.edu	37	8	33449645	33449645	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:33449645G>T	ENST00000256261.4	-	4	1039	c.522C>A	c.(520-522)acC>acA	p.T174T	DUSP26_ENST00000523956.1_Silent_p.T174T	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	174	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CCTCCACGAGGGTAAGGTGGT	0.622000													8	26					1.08611e-07	1.36452e-07	0.387290	1	0
UNC5D	137970	broad.mit.edu	37	8	35624419	35624419	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:35624419G>T	ENST00000287272.2	+	14	2126		c.e14-1		UNC5D_ENST00000449677.1_Splice_Site|UNC5D_ENST00000404895.2_Splice_Site|UNC5D_ENST00000416672.1_Splice_Site|UNC5D_ENST00000453357.2_Splice_Site|UNC5D_ENST00000420357.1_Splice_Site			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)						apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTCCCCTGCAGGAAGTCCCGT	0.562000													21	45					7.38237e-10	1.00898e-09	0.706142	1	0
TRRAP	8295	broad.mit.edu	37	7	98529088	98529088	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:98529088G>A	ENST00000359863.4	+	26	3861	c.3652G>A	c.(3652-3654)Gca>Aca	p.A1218T	TRRAP_ENST00000355540.3_Missense_Mutation_p.A1218T|TRRAP_ENST00000446306.3_Missense_Mutation_p.A1217T	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1218					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GATGCGGTGCGCAACGCCTTT	0.542000													7	28					0	0	0.248553	0	0
CXorf67	340602	broad.mit.edu	37	X	51149965	51149965	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:51149965G>T	ENST00000342995.2	+	1	199	c.97G>T	c.(97-99)Gcc>Tcc	p.A33S						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						CTCCGGGGATGCCTGCGGGAC	0.642000													14	11					2.32078e-09	3.13323e-09	0.479597	1	0
AMOT	154796	broad.mit.edu	37	X	112048220	112048220	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:112048220C>A	ENST00000371959.3	-	5	1730	c.1731G>T	c.(1729-1731)caG>caT	p.Q577H	AMOT_ENST00000371962.1_Missense_Mutation_p.Q345H|AMOT_ENST00000371958.1_Missense_Mutation_p.Q345H|AMOT_ENST00000304758.1_Missense_Mutation_p.Q168H|AMOT_ENST00000524145.1_Missense_Mutation_p.Q577H	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	577					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						TACTCAGGGCCTGATCTCGGA	0.547000													34	123					1.47197e-15	2.38814e-15	0.834066	1	0
CRYBB1	1414	broad.mit.edu	37	22	26997914	26997914	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:26997914C>A	ENST00000215939.2	-	5	634	c.504G>T	c.(502-504)ggG>ggT	p.G168G		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	168	Beta/gamma crystallin 'Greek key' 3.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						GTGCGTCGTCCCCCTGGATCT	0.607000													22	80					7.4402e-23	1.39745e-22	0.667858	1	0
FLG	2312	broad.mit.edu	37	1	152283256	152283256	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152283256C>A	ENST00000368799.1	-	3	4141	c.4106G>T	c.(4105-4107)aGa>aTa	p.R1369I	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1369	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGAGTGTCTGGAGCTGTC	0.537000									Ichthyosis				344	608					7.28424e-134	1.67386e-133	0.870114	1	0
PSMG3	84262	broad.mit.edu	37	7	1608937	1608937	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:1608937C>A	ENST00000288607.2	-	1	692	c.39G>T	c.(37-39)acG>acT	p.T13T	PSMG3_ENST00000252329.3_Silent_p.T13T|PSMG3_ENST00000404674.3_Silent_p.T13T	NM_032302.3	NP_115678.1	Q9BT73	PSMG3_HUMAN	proteasome (prosome, macropain) assembly chaperone 3	13										lung(2)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.63e-15)		ACACCACCTCCGTCTTCTGCT	0.552000													19	28					8.24728e-16	1.34501e-15	0.681144	1	0
CDH4	1002	broad.mit.edu	37	20	60498695	60498695	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:60498695C>A	ENST00000360469.5	+	10	1649	c.1561C>A	c.(1561-1563)Ccc>Acc	p.P521T	CDH4_ENST00000543233.1_Missense_Mutation_p.P447T	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	521	Cadherin 4.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGAGGGCGTGCCCCCCGGCAC	0.627000													22	45					2.89027e-11	4.15863e-11	0.624587	1	0
F8	2157	broad.mit.edu	37	X	154158694	154158694	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:154158694G>T	ENST00000360256.4	-	14	3571	c.3371C>A	c.(3370-3372)tCa>tAa	p.S1124*		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1124	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCACCTTGCTGATTCTGGCAA	0.433000													6	61					0.000442599	0.00048485	0.335167	1	0
ZFP36	7538	broad.mit.edu	37	19	39898869	39898869	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:39898869G>T	ENST00000597629.1	+	2	603	c.529G>T	c.(529-531)Gac>Tac	p.D177Y	ZFP36_ENST00000248673.3_Missense_Mutation_p.D171Y			P26651	TTP_HUMAN	ZFP36 ring finger protein	171					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCTAGCGAAGACCTGGCGGC	0.657000													79	70					6.11987e-43	1.33151e-42	0.870114	1	0
KLHL23	151230	broad.mit.edu	37	2	170606185	170606185	+	Silent	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:170606185G>C	ENST00000392647.2	+	4	1864	c.1620G>C	c.(1618-1620)gtG>gtC	p.V540V	KLHL23_ENST00000602521.1_Silent_p.V47V|KLHL23_ENST00000272797.4_Silent_p.V540V	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	540										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						GGGAAATAGTGGGTAATCTTC	0.393000													98	125					0	0	0.870114	0	0
MMRN1	22915	broad.mit.edu	37	4	90874432	90874432	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:90874432G>T	ENST00000394980.1	+	9	3869	c.3550G>T	c.(3550-3552)Gat>Tat	p.D1184Y	MMRN1_ENST00000264790.2_Missense_Mutation_p.D1184Y|MMRN1_ENST00000394981.1_Missense_Mutation_p.D487Y|MMRN1_ENST00000508372.1_Missense_Mutation_p.D926Y			Q13201	MMRN1_HUMAN	multimerin 1	1184	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AATACACTGTGATAGGGTTTT	0.383000													24	62					3.17567e-06	3.75887e-06	0.729181	1	0
FAM163B	642968	broad.mit.edu	37	9	136444267	136444267	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:136444267C>A	ENST00000496132.1	-	3	622	c.378G>T	c.(376-378)gtG>gtT	p.V126V	FAM163B_ENST00000356873.3_Silent_p.V126V			P0C2L3	F163B_HUMAN	family with sequence similarity 163, member B	126						integral to membrane				large_intestine(1)	1						CCTCCTGGCTCACGCTCTTGT	0.711000													3	12					0.00024832	0.000273297	0.150653	1	0
C1orf173	127254	broad.mit.edu	37	1	75037595	75037595	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:75037595C>A	ENST00000326665.5	-	14	4017	c.3799G>T	c.(3799-3801)Gtg>Ttg	p.V1267L	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1267	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GTCCTTAGCACGACATCCACT	0.577000													33	88					8.16277e-20	1.46169e-19	0.827153	1	0
LMAN2L	81562	broad.mit.edu	37	2	97377718	97377718	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:97377718G>A	ENST00000264963.4	-	5	574	c.552C>T	c.(550-552)ctC>ctT	p.L184L	LMAN2L_ENST00000534882.1_Silent_p.L39L|LMAN2L_ENST00000537039.1_Silent_p.L46L|LMAN2L_ENST00000377079.4_Silent_p.L195L|LMAN2L_ENST00000426463.2_Silent_p.L50L	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	184	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						GATCATAGCTGAGGGAGCCGT	0.557000													18	83					0	0	0.639603	0	0
WT1	7490	broad.mit.edu	37	11	32456479	32456479	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:32456479G>T	ENST00000332351.3	-	1	697	c.413C>A	c.(412-414)tCc>tAc	p.S138Y	WT1_ENST00000448076.3_Missense_Mutation_p.S138Y	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	70					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.H69fs*20(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TTTGATGAAGGAGTGAggcgg	0.721000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				7	10					0.0293803	0.0301822	0.248553	1	0
DENND2A	27147	broad.mit.edu	37	7	140227246	140227246	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:140227246C>A	ENST00000275884.6	-	14	2794	c.2377G>T	c.(2377-2379)Gcc>Tcc	p.A793S	DENND2A_ENST00000537639.1_Missense_Mutation_p.A793S|DENND2A_ENST00000496613.1_Missense_Mutation_p.A793S			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	793	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TGCTGCCAGGCGAAGGGGTAG	0.672000													7	10					8.12818e-05	9.07848e-05	0.248553	1	0
IGHV3-72	28410	broad.mit.edu	37	14	107199084	107199084	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:107199084G>T	ENST00000433072.2	-	0	284																											TTTCTAGTACGGCCAACCCAC	0.522000													52	77					2.84144e-21	5.22225e-21	0.870114	1	0
PLCH2	9651	broad.mit.edu	37	1	2436204	2436204	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:2436204G>T	ENST00000378486.3	+	22	4077	c.3803G>T	c.(3802-3804)aGc>aTc	p.S1268I	PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000419816.2_Missense_Mutation_p.S1268I|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000378488.3_Missense_Mutation_p.S1232I	NM_014638.2	NP_055453.2	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1268					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TTTGCCCCTAGCTTTGAGGGC	0.692000													16	122					2.39187e-15	3.83433e-15	0.575678	1	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22472967	22472967	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:22472967G>T	ENST00000557788.2	-	0	303																											ACAGAGCTCAGCTTCAGGGAG	0.557000													17	356					2.37509e-13	3.65488e-13	0.592651	1	0
NFASC	23114	broad.mit.edu	37	1	204944495	204944495	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:204944495A>T	ENST00000367172.4	+	15	1983	c.1655A>T	c.(1654-1656)aAa>aTa	p.K552I	NFASC_ENST00000539706.1_Missense_Mutation_p.K563I|NFASC_ENST00000360049.4_Missense_Mutation_p.K563I|NFASC_ENST00000367171.4_Missense_Mutation_p.K552I|NFASC_ENST00000367170.4_Missense_Mutation_p.K552I|NFASC_ENST00000367169.4_Missense_Mutation_p.K552I|NFASC_ENST00000404907.1_Missense_Mutation_p.K563I|NFASC_ENST00000338586.6_Missense_Mutation_p.K552I|NFASC_ENST00000513543.1_Missense_Mutation_p.K563I|NFASC_ENST00000338515.6_Missense_Mutation_p.K552I|NFASC_ENST00000339876.6_Missense_Mutation_p.K552I|NFASC_ENST00000403080.1_Missense_Mutation_p.K552I|NFASC_ENST00000401399.1_Missense_Mutation_p.K552I|NFASC_ENST00000404076.1_Missense_Mutation_p.K546I			O94856	NFASC_HUMAN	neurofascin	552	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCTCCCTGAAACTCACCGTC	0.587000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	105	89					0	0	0.870114	0	0
PLCG2	5336	broad.mit.edu	37	16	81965211	81965211	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:81965211T>C	ENST00000359376.3	+	25	2905	c.2691T>C	c.(2689-2691)ttT>ttC	p.F897F		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	897					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						AGGAGCTCTTTGAGTGGTTTC	0.567000													23	34					0	0	0.729181	0	0
OR4D10	390197	broad.mit.edu	37	11	59245107	59245107	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:59245107G>T	ENST00000530162.1	+	1	262	c.205G>T	c.(205-207)Gcc>Tcc	p.A69S		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTATCTATTGCCGATATCTG	0.443000													36	88					2.75727e-19	4.85879e-19	0.804634	1	0
LCP2	3937	broad.mit.edu	37	5	169675711	169675711	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:169675711C>A	ENST00000046794.5	-	21	2207	c.1592G>T	c.(1591-1593)gGg>gTg	p.G531V	C5orf58_ENST00000517575.1_Intron|LCP2_ENST00000521416.1_Missense_Mutation_p.G326V	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	531					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		CTATGGGTACCCTGCAGCATG	0.468000													71	94					3.90494e-43	8.51576e-43	0.870114	1	0
PRRC1	133619	broad.mit.edu	37	5	126860329	126860329	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:126860329A>G	ENST00000442138.2	+	3	356	c.210A>G	c.(208-210)gcA>gcG	p.A70A	PRRC1_ENST00000512635.2_Silent_p.A70A|PRRC1_ENST00000296666.8_Silent_p.A70A			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	70	Pro-rich.			A -> T (in Ref. 4; CAH10384).		Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GGCCTTCAGCACCATTACCTT	0.522000													64	129					0	0	0.870114	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161166389	161166389	+	Silent	SNP	C	C	A	rs150760814		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:161166389C>A	ENST00000367996.4	-	2	1343	c.915G>T	c.(913-915)tcG>tcT	p.S305S	ADAMTS4_ENST00000367995.3_Silent_p.S305S	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	305	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGTCAGGGTCCGAGTCCTCAG	0.637000													54	80					1.93748e-29	3.89566e-29	0.870114	1	0
ARL11	115761	broad.mit.edu	37	13	50204623	50204623	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:50204623C>A	ENST00000282026.1	+	2	375	c.40C>A	c.(40-42)Cag>Aag	p.Q14K	ARL11_ENST00000490932.1_Intron	NM_138450.5	NP_612459.1	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	14					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding			kidney(1)|large_intestine(4)|ovary(1)	6		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		GGCGGAAGCCCAGGTGGTGAT	0.582000													36	46					1.51926e-22	2.84785e-22	0.870114	1	0
ADRA2A	150	broad.mit.edu	37	10	112838481	112838481	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:112838481C>A	ENST00000280155.2	+	1	1692	c.727C>A	c.(727-729)Cgc>Agc	p.R243S		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	228					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	GCGTCGCACCCGCGTGCCACC	0.721000													3	7					0.115264	0.117385	0.115264	1	0
TBC1D23	55773	broad.mit.edu	37	3	100002604	100002604	+	Missense_Mutation	SNP	G	G	T	rs111456348		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:100002604G>T	ENST00000394144.4	+	4	432	c.425G>T	c.(424-426)cGc>cTc	p.R142L	TBC1D23_ENST00000475134.1_Intron|TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000344949.5_Missense_Mutation_p.R142L	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	142	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						CAACTGCCACGCAGCGATTTA	0.343000													40	108					5.73435e-26	1.11258e-25	0.870114	1	0
ACOXL	55289	broad.mit.edu	37	2	111691150	111691150	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:111691150G>T	ENST00000389811.4	+	12	1214	c.990G>T	c.(988-990)ggG>ggT	p.G330G	ACOXL_ENST00000439055.1_Silent_p.G330G			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	330					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						TGGTGGCGGGGCTGAAGGCCT	0.647000													15	33					6.72482e-11	9.57346e-11	0.479597	1	0
IQGAP3	128239	broad.mit.edu	37	1	156513998	156513998	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:156513998C>T	ENST00000361170.2	-	21	2416	c.2406G>A	c.(2404-2406)cgG>cgA	p.R802R		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	802	IQ 3.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGCCCACATCCGGGCCCAGG	0.577000													12	129					0	0	0.479597	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923727	43923727	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:43923727G>A	ENST00000329196.5	+	1	1472	c.1455G>A	c.(1453-1455)ctG>ctA	p.L485L	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	485						integral to membrane	aspartic-type endopeptidase activity										TGGGCCTGCTGGTCACATTCA	0.602000													32	62					0	0	0.769981	0	0
FERD3L	222894	broad.mit.edu	37	7	19184801	19184801	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19184801G>A	ENST00000275461.3	-	1	243	c.185C>T	c.(184-186)cCa>cTa	p.P62L	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	62					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						ctcttcttctgggtccccctc	0.637000													19	37					0	0	0.624587	0	0
IFNA2	3440	broad.mit.edu	37	9	21385305	21385305	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:21385305C>A	ENST00000380206.2	-	1	91	c.24G>T	c.(22-24)ctG>ctT	p.L8L		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	8					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GGAGGGCCACCAGTAAAGCAA	0.542000													64	37					3.1711e-36	6.68309e-36	0.870114	1	0
RBM25	58517	broad.mit.edu	37	14	73578958	73578958	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:73578958G>C	ENST00000261973.7	+	17	2676	c.2391_splice	c.e17+1	p.K797_splice	RBM25_ENST00000527432.1_Splice_Site_p.K797_splice|RBM25_ENST00000532483.1_3'UTR	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	797	PWI.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TTTGTTCTAAGGTTAGTCTTC	0.299000													6	81					0	0	0.217242	0	0
OR8A1	390275	broad.mit.edu	37	11	124440496	124440496	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:124440496G>T	ENST00000284287.3	+	1	604	c.532G>T	c.(532-534)Ggc>Tgc	p.G178C		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G178C(1)		haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		AATAGAAACTGGCCTCATGTT	0.493000													23	76					1.42536e-11	2.07465e-11	0.681144	1	0
PTTG1IP	754	broad.mit.edu	37	21	46281179	46281179	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:46281179C>A	ENST00000330938.3	-	3	396	c.176G>T	c.(175-177)tGg>tTg	p.W59L	PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397886.3_Missense_Mutation_p.W38L|PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000397887.3_Missense_Mutation_p.W59L	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	59	PSI.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		AGTGTTGCACCAAAGACACTG	0.502000													16	24					1.15088e-07	1.44013e-07	0.500413	1	0
NF1	4763	broad.mit.edu	37	17	29556374	29556374	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:29556374G>T	ENST00000358273.4	+	21	3124	c.2741G>T	c.(2740-2742)cGg>cTg	p.R914L	NF1_ENST00000356175.3_Missense_Mutation_p.R914L	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	914					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)|p.R914L(2)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTTCAAATACGGACCAATGTT	0.413000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			30	87					1.36615e-20	2.48174e-20	0.769981	1	0
FBXO18	84893	broad.mit.edu	37	10	5978520	5978520	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:5978520C>G	ENST00000379999.5	+	21	3188	c.3084C>G	c.(3082-3084)gtC>gtG	p.V1028V	FBXO18_ENST00000379994.1_Intron|FBXO18_ENST00000397269.3_Silent_p.V481V|FBXO18_ENST00000362091.4_Silent_p.V977V	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	977					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TTGACACCGTCCTTACCATGA	0.488000													16	93					0	0	0.624587	0	0
NRG1	3084	broad.mit.edu	37	8	32600215	32600215	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:32600215G>T	ENST00000356819.4	+	7	1172	c.655G>T	c.(655-657)Gat>Tat	p.D219Y	NRG1_ENST00000539990.1_Missense_Mutation_p.D65Y|NRG1_ENST00000519301.1_Missense_Mutation_p.D164Y|NRG1_ENST00000523079.1_Missense_Mutation_p.D219Y|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000520502.2_Missense_Mutation_p.D274Y|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000287840.5_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000287842.3_Missense_Mutation_p.D219Y|NRG1_ENST00000520407.1_Missense_Mutation_p.D400Y|NRG1_ENST00000287845.5_Missense_Mutation_p.D185Y|NRG1_ENST00000341377.5_Silent_p.V241V	NM_001159999.1|NM_013956.3	NP_001153471.1|NP_039250.2	Q02297	NRG1_HUMAN	neuregulin 1	219	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GTTTACTGGTGATCGCTGCCA	0.433000													21	88					1.96292e-10	2.74459e-10	0.592651	1	0
ZNF592	9640	broad.mit.edu	37	15	85345453	85345453	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:85345453G>A	ENST00000299927.3	+	8	3655	c.3633G>A	c.(3631-3633)atG>atA	p.M1211I	ZNF592_ENST00000560079.2_Missense_Mutation_p.M1211I			Q92610	ZN592_HUMAN	zinc finger protein 592	1211					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGGTGCCCATGGAGACTAGAG	0.642000													21	23					0	0	0.608945	0	0
GLI2	2736	broad.mit.edu	37	2	121555036	121555036	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:121555036C>T	ENST00000452319.1	+	2	200	c.140C>T	c.(139-141)gCc>gTc	p.A47V	GLI2_ENST00000314490.11_5'UTR|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.A47V			P10070	GLI2_HUMAN	GLI family zinc finger 2	47					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GCGGTAGCTGCCCAAGGAGGT	0.577000													9	29					0	0	0.361761	0	0
FLG	2312	broad.mit.edu	37	1	152279739	152279739	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:152279739G>T	ENST00000368799.1	-	3	7658	c.7623C>A	c.(7621-7623)gcC>gcA	p.A2541A	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2541	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAGCTGTCGGCCCGAGAGG	0.582000									Ichthyosis				92	391					3.54964e-55	7.9152e-55	0.870114	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21796581	21796581	+	Splice_Site	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:21796581A>T	ENST00000206660.6	+	18	2895		c.e18-1		RPGRIP1_ENST00000382933.4_Splice_Site|RPGRIP1_ENST00000307974.4_Splice_Site|RPGRIP1_ENST00000557771.1_Splice_Site|RPGRIP1_ENST00000556336.1_Splice_Site|RPGRIP1_ENST00000400017.2_Splice_Site			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1						response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTTTCTATTCAGGATCAGATG	0.438000													16	33					0	0	0.520397	0	0
SPIN4	139886	broad.mit.edu	37	X	62570087	62570087	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:62570087C>A	ENST00000374884.2	-	1	1136	c.558G>T	c.(556-558)caG>caT	p.Q186H	SPIN4_ENST00000335144.3_Missense_Mutation_p.Q204H|SPIN4-AS1_ENST00000451979.1_RNA			Q56A73	SPIN4_HUMAN	spindlin family, member 4	204					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						CATGCTCCACCTGCTTGCCCA	0.458000													20	70					4.16121e-05	4.70072e-05	0.639603	1	0
ZBTB34	403341	broad.mit.edu	37	9	129642150	129642150	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:129642150A>T	ENST00000319119.4	+	2	557	c.472A>T	c.(472-474)Agc>Tgc	p.S158C	ZBTB34_ENST00000373452.2_Missense_Mutation_p.S154C	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						AGTGAAAGACAGCAGCTTCTT	0.547000													33	42					0	0	0.769981	0	0
C20orf96	140680	broad.mit.edu	37	20	257889	257889	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:257889T>C	ENST00000360321.2	-	7	839	c.701A>G	c.(700-702)cAg>cGg	p.Q234R	C20orf96_ENST00000400269.3_Missense_Mutation_p.Q176R|C20orf96_ENST00000382369.5_Missense_Mutation_p.Q199R	NM_080571.1|NM_153269.2	NP_542138.1|NP_695001.2	Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	234										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CTTAACCTGCTGCAGCTGGCG	0.567000													6	132					0	0	0.278610	0	0
CHSY3	337876	broad.mit.edu	37	5	129520678	129520678	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:129520678G>T	ENST00000305031.4	+	3	2201	c.1843G>T	c.(1843-1845)Ggg>Tgg	p.G615W		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	615			G -> E (in dbSNP:rs10068403).			Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AGAAATGGGAGGGCACAATGA	0.363000													9	9					2.17888e-05	2.49279e-05	0.335167	1	0
SETBP1	26040	broad.mit.edu	37	18	42532771	42532771	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:42532771C>A	ENST00000282030.5	+	4	3762	c.3466C>A	c.(3466-3468)Cat>Aat	p.H1156N		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1156						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAAACACAAGCATAAGCACAA	0.552000									Schinzel-Giedion syndrome				14	14					3.41278e-10	4.73662e-10	0.520397	1	0
LCT	3938	broad.mit.edu	37	2	136567175	136567175	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:136567175G>T	ENST00000264162.2	-	8	2752	c.2742C>A	c.(2740-2742)tcC>tcA	p.S914S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	914	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCTGATAAGCGGAAGAGGACA	0.517000													16	28					4.7546e-09	6.31933e-09	0.500413	1	0
REG1P	5969	broad.mit.edu	37	2	79365036	79365036	+	RNA	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:79365036G>C	ENST00000444841.1	-	0	166																											CATGAGGATAGAGTGAGGGCT	0.468000													7	6					0	0	0.248553	0	0
RUNX3	864	broad.mit.edu	37	1	25229132	25229132	+	Silent	SNP	G	G	C	rs144597350		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:25229132G>C	ENST00000399916.1	-	6	1209	c.771C>G	c.(769-771)tcC>tcG	p.S257S	RUNX3_ENST00000338888.3_Silent_p.S257S|RUNX3_ENST00000540420.1_Silent_p.S150S|RUNX3_ENST00000308873.6_Silent_p.S243S|RUNX3_ENST00000496967.1_5'UTR	NM_001031680.2	NP_001026850.1	Q13761	RUNX3_HUMAN	runt-related transcription factor 3	243	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(3)	18		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GGCGGGGGTCGGAGAATGGGT	0.622000													48	89					0	0	0.870114	0	0
SNTG1	54212	broad.mit.edu	37	8	51306826	51306826	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:51306826G>T	ENST00000522124.1	+	3	688		c.e3+1		SNTG1_ENST00000276467.5_Splice_Site|SNTG1_ENST00000517473.1_Splice_Site|SNTG1_ENST00000518864.1_Splice_Site	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CTGTGAGGAGGTGAGTACAGA	0.443000													13	22					4.7546e-09	6.31933e-09	0.500413	1	0
ZNF208	7757	broad.mit.edu	37	19	22157415	22157415	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22157415G>T	ENST00000397126.4	-	4	569	c.421C>A	c.(421-423)Cag>Aag	p.Q141K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTTTGCTCTGTGTAGTTGTC	0.323000													33	30					3.66082e-28	7.29837e-28	0.812448	1	0
EPHB6	2051	broad.mit.edu	37	7	142566477	142566477	+	Missense_Mutation	SNP	C	C	A	rs8177160	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142566477C>A	ENST00000392957.2	+	15	3053	c.2266C>A	c.(2266-2268)Ctg>Atg	p.L756M	EPHB6_ENST00000442129.1_Missense_Mutation_p.L756M|EPHB6_ENST00000411471.2_Missense_Mutation_p.L479M	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	756	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCTTGGCCCCCTGGACAGCTT	0.607000													17	78					0.014323	0.0148927	0.624587	1	0
KEL	3792	broad.mit.edu	37	7	142639553	142639553	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:142639553G>A	ENST00000355265.2	-	18	2479	c.2005C>T	c.(2005-2007)Ccc>Tcc	p.P669S		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	669					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					ATCTGCTGGGGGCTGAGGTCC	0.577000													4	18					0	0	0.184627	0	0
HEPHL1	341208	broad.mit.edu	37	11	93822023	93822023	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:93822023G>T	ENST00000315765.9	+	12	2191	c.2183G>T	c.(2182-2184)cGg>cTg	p.R728L		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	728					copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TCTGAGCAGCGGTACGGGATG	0.502000													16	41					1.15919e-05	1.33922e-05	0.575678	1	0
ZNF334	55713	broad.mit.edu	37	20	45132981	45132981	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:45132981C>A	ENST00000593880.1	-	3	476	c.182G>T	c.(181-183)aGa>aTa	p.R61I	ZNF334_ENST00000347606.4_Intron|ZNF334_ENST00000457685.2_Intron			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGACCAAGATCTTTGGACATC	0.408000													4	7					0.00024832	0.000273297	0.150653	1	0
OPLAH	26873	broad.mit.edu	37	8	145111988	145111988	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:145111988G>A	ENST00000426825.1	-	12	1650	c.1569C>T	c.(1567-1569)gcC>gcT	p.A523A	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	523							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CGTCAGCCAGGGCCAGCCCCA	0.677000													17	7					0	0	0.624587	0	0
MYBPC3	4607	broad.mit.edu	37	11	47367761	47367761	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:47367761T>C	ENST00000545968.1	-	12	1141	c.1087A>G	c.(1087-1089)Aca>Gca	p.T363A	MYBPC3_ENST00000399249.2_Missense_Mutation_p.T363A|MYBPC3_ENST00000256993.4_Missense_Mutation_p.T363A	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	363	Ig-like C2-type 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GGCTAACCTGTGCTCTTCTTC	0.607000													5	51					0	0	0.278610	0	0
TMEM132A	54972	broad.mit.edu	37	11	60699545	60699545	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:60699545G>A	ENST00000005286.4	+	7	1458	c.1305G>A	c.(1303-1305)ttG>ttA	p.L435L	TMEM132A_ENST00000453848.2_Silent_p.L434L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	434						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GGGGGGCCTTGGTGGAGGTGA	0.632000													44	77					0	0	0.870114	0	0
CCDC54	84692	broad.mit.edu	37	3	107097304	107097304	+	Silent	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:107097304C>G	ENST00000261058.1	+	1	1117	c.870C>G	c.(868-870)acC>acG	p.T290T		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	290										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						AGGTCATAACCCAGAGATACT	0.423000													39	61					0	0	0.834066	0	0
RYR2	6262	broad.mit.edu	37	1	237890454	237890454	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:237890454C>G	ENST00000366574.2	+	76	11110	c.10793C>G	c.(10792-10794)gCt>gGt	p.A3598G	RYR2_ENST00000542537.1_Missense_Mutation_p.A3582G|RYR2_ENST00000360064.6_Missense_Mutation_p.A3596G	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3598					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGAAAAGGGCTGTTGTAGCC	0.388000													18	70					0	0	0.667858	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519322	113519322	+	Missense_Mutation	SNP	C	C	A	rs144397367		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:113519322C>A	ENST00000284601.3	-	4	1893	c.1825G>T	c.(1825-1827)Gct>Tct	p.A609S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	609					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CCTCCTAAAGCGCTGCCTTCA	0.403000													63	141					7.62596e-35	1.59114e-34	0.870114	1	0
KRT73	319101	broad.mit.edu	37	12	53011877	53011877	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:53011877G>T	ENST00000305748.3	-	1	466	c.432C>A	c.(430-432)gcC>gcA	p.A144A		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	144	Coil 1A.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAATGAAGGAGGCGAACTTGT	0.537000													20	95					3.5997e-14	5.64553e-14	0.624587	1	0
S1PR5	53637	broad.mit.edu	37	19	10625398	10625398	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:10625398C>A	ENST00000439028.3	-	2	415	c.290G>T	c.(289-291)gGg>gTg	p.G97V	S1PR5_ENST00000333430.4_Missense_Mutation_p.G97V	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	97						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						CGTGAGCGGCCCCGACAGTAG	0.682000													8	9					0.00448238	0.0047419	0.307466	1	0
CSMD2	114784	broad.mit.edu	37	1	34238173	34238173	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:34238173C>A	ENST00000373381.4	-	13	2019	c.1843G>T	c.(1843-1845)Gtg>Ttg	p.V615L	CSMD2_ENST00000338325.1_Missense_Mutation_p.V223L	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	575	CUB 4.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACTTACACACGCAGCCTGGC	0.582000													21	64					1.96895e-08	2.54503e-08	0.639603	1	0
KIF4A	24137	broad.mit.edu	37	X	69595093	69595093	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:69595093G>A	ENST00000374403.3	+	17	1900	c.1818G>A	c.(1816-1818)gaG>gaA	p.E606E	KIF4A_ENST00000374388.3_Silent_p.E606E	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	606					anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						AGGAGCTGGAGGGTCAAATTG	0.478000													7	29					0	0	0.278610	0	0
FSD1	79187	broad.mit.edu	37	19	4307950	4307950	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:4307950G>T	ENST00000221856.6	+	4	462	c.315G>T	c.(313-315)ctG>ctT	p.L105L	FSD1_ENST00000598010.1_3'UTR|FSD1_ENST00000597590.1_Silent_p.L105L	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	105	COS.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCAGACTCTGCAGGCCATGG	0.592000													29	13					6.53348e-20	1.17105e-19	0.788014	1	0
USP26	83844	broad.mit.edu	37	X	132161214	132161214	+	Silent	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:132161214T>G	ENST00000511190.1	-	6	1504	c.1035A>C	c.(1033-1035)ctA>ctC	p.L345L	USP26_ENST00000370832.1_Silent_p.L345L|USP26_ENST00000406273.1_Silent_p.L345L	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	345					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					TAAAAAAAAGTAGCCGTGCCA	0.378000													5	24					0	0	0.184627	0	0
C1orf112	55732	broad.mit.edu	37	1	169798490	169798490	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:169798490G>A	ENST00000286031.6	+	13	1914	c.1214G>A	c.(1213-1215)aGt>aAt	p.S405N	C1orf112_ENST00000498289.1_3'UTR|C1orf112_ENST00000413811.2_3'UTR|C1orf112_ENST00000359326.4_Missense_Mutation_p.S405N	NM_018186.2	NP_060656.2	Q9NSG2	CA112_HUMAN	chromosome 1 open reading frame 112	405										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGATTAAAGAGTAAGGGGAAA	0.423000													15	86					0	0	0.479597	0	0
PRR23C	389152	broad.mit.edu	37	3	138763051	138763051	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:138763051C>A	ENST00000413199.1	-	1	683	c.412G>T	c.(412-414)Gag>Tag	p.E138*	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Nonsense_Mutation_p.E138*	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	138										breast(2)|lung(7)|skin(2)	11						ACTTCCTGCTCGACGACGACG	0.647000													5	13					0.0293803	0.0301822	0.248553	1	0
ADAMTS1	9510	broad.mit.edu	37	21	28210442	28210442	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:28210442G>T	ENST00000284984.2	-	9	2814	c.2360C>A	c.(2359-2361)aCc>aAc	p.T787N		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	787	Spacer.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		TTGCTCTAAGGTGGACAAAGT	0.478000													8	21					3.09899e-07	3.82696e-07	0.307466	1	0
PRSS12	8492	broad.mit.edu	37	4	119234375	119234375	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:119234375C>T	ENST00000296498.3	-	7	1752	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	490						membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						GCCTGTGTCCCTCGCCGCCAG	0.537000													4	17					0	0	0.217242	0	0
FOXRED1	55572	broad.mit.edu	37	11	126143342	126143342	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:126143342G>T	ENST00000263578.5	+	4	603	c.529G>T	c.(529-531)Gtg>Ttg	p.V177L	FOXRED1_ENST00000442061.2_Missense_Mutation_p.V7L|FOXRED1_ENST00000532125.1_Missense_Mutation_p.V163L|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	177						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CAACGTGAAAGTGCAGAGGTG	0.572000													38	46					2.47872e-24	4.74564e-24	0.853193	1	0
BRSK1	84446	broad.mit.edu	37	19	55816284	55816284	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55816284G>T	ENST00000309383.1	+	14	1990	c.1713G>T	c.(1711-1713)atG>atT	p.M571I	BRSK1_ENST00000326848.7_Missense_Mutation_p.M266I|BRSK1_ENST00000590333.1_Missense_Mutation_p.M587I|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	571					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGCGCAAGATGCAGGGTATGG	0.627000													50	22					1.21705e-43	2.65718e-43	0.870114	1	0
CHSY1	22856	broad.mit.edu	37	15	101717884	101717884	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:101717884C>A	ENST00000254190.3	-	3	2593	c.2118G>T	c.(2116-2118)gtG>gtT	p.V706V	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	706					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAAAGCCACCCACTCGGACAA	0.483000													46	63					3.50607e-19	6.16099e-19	0.870114	1	0
ZNF676	163223	broad.mit.edu	37	19	22363674	22363674	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:22363674T>G	ENST00000397121.2	-	3	1162	c.845A>C	c.(844-846)aAa>aCa	p.K282T		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTCTTCACATTTGTAGGGCTT	0.423000													6	71					0	0	0.278610	0	0
SHFM1	7979	broad.mit.edu	37	7	96251933	96251933	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:96251933C>G	ENST00000417009.1	-	3	290	c.193G>C	c.(193-195)Gaa>Caa	p.E65Q	RP11-682N22.1_ENST00000606019.1_lincRNA			P60896	DSS1_HUMAN	split hand/foot malformation (ectrodactyly) type 1	62					proteolysis	proteasome complex	peptidase activity|protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_cancers(62;4.24e-09)|all_epithelial(64;5.59e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0353)|Lung NSC(181;0.0987)					CCCCGCTATTCCTCCAGTTCA	0.428000								Homologous recombination					11	21					0	0	0.500413	0	0
PRDM14	63978	broad.mit.edu	37	8	70964382	70964382	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:70964382C>A	ENST00000276594.2	-	8	1847	c.1646G>T	c.(1645-1647)aGc>aTc	p.S549I		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	549					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CCCACAGATGCTGCATGAGCA	0.483000													21	107					7.92952e-12	1.16863e-11	0.667858	1	0
DLX6	1750	broad.mit.edu	37	7	96637092	96637092	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:96637092C>A	ENST00000518156.2	+	2	1009	c.579C>A	c.(577-579)gcC>gcA	p.A193A	DLX6-AS1_ENST00000437331.2_RNA|DLX6_ENST00000007660.5_Silent_p.A165A|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6_ENST00000493273.2_3'UTR|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6_ENST00000555308.1_Silent_p.A65A|DLX6-AS1_ENST00000605417.1_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	75					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					AGTATCTGGCCCTTCCAGAGA	0.502000													10	9					4.68919e-08	5.99121e-08	0.361761	1	0
PLVAP	83483	broad.mit.edu	37	19	17487896	17487896	+	Nonsense_Mutation	SNP	C	C	A	rs148432183		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:17487896C>A	ENST00000252590.4	-	1	263	c.202G>T	c.(202-204)Gag>Tag	p.E68*		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	68						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TATAGGCCCTCGGCTCGGCGC	0.592000													13	18					1.5842e-08	2.06902e-08	0.435327	1	0
OTOA	146183	broad.mit.edu	37	16	21698821	21698821	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:21698821A>T	ENST00000388958.3	+	7	488	c.487A>T	c.(487-489)Aca>Tca	p.T163S	OTOA_ENST00000286149.4_Missense_Mutation_p.T163S|OTOA_ENST00000388956.4_Missense_Mutation_p.T84S	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	163					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GTTTCTCATCACACTGGAGAG	0.542000													33	80					0	0	0.819951	0	0
BICC1	80114	broad.mit.edu	37	10	60559983	60559983	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:60559983C>T	ENST00000373886.3	+	13	1759	c.1755C>T	c.(1753-1755)tcC>tcT	p.S585S	BICC1_ENST00000263103.1_Silent_p.S211S	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	585					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						GTGCAATATCCACTTCATCAC	0.383000													3	16					0	0	0.115264	0	0
ACTN3	89	broad.mit.edu	37	11	66325642	66325642	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:66325642C>A	ENST00000513398.1	+	0	1370				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						AGCCTGGACCCGGGGTAGGTA	0.617000													30	50					1.90571e-15	3.07067e-15	0.796494	1	0
ANKK1	255239	broad.mit.edu	37	11	113258733	113258733	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:113258733C>T	ENST00000303941.3	+	1	221	c.127C>T	c.(127-129)Cgc>Tgc	p.R43C		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	43	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GCGGCACAGGCGCTGGCGGAC	0.701000													3	3					0	0	0.150653	0	0
ADRA1A	148	broad.mit.edu	37	8	26721982	26721982	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:26721982C>A	ENST00000380573.3	-	2	1528	c.505G>T	c.(505-507)Gcc>Tcc	p.A169S	ADRA1A_ENST00000380586.1_Missense_Mutation_p.A169S|ADRA1A_ENST00000380587.1_Missense_Mutation_p.A169S|ADRA1A_ENST00000276393.4_Missense_Mutation_p.A169S|ADRA1A_ENST00000519229.1_Missense_Mutation_p.A169S|ADRA1A_ENST00000380572.3_Missense_Mutation_p.A169S|ADRA1A_ENST00000380582.3_Missense_Mutation_p.A169S|ADRA1A_ENST00000358857.5_Missense_Mutation_p.A169S|ADRA1A_ENST00000354550.4_Missense_Mutation_p.A169S|ADRA1A_ENST00000380581.2_Missense_Mutation_p.A169S			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	169					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TCCTCGGGGGCCGGCTGCCTC	0.627000													10	31					0.000673444	0.000729241	0.361761	1	0
DOPEY2	9980	broad.mit.edu	37	21	37602857	37602857	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr21:37602857G>T	ENST00000399151.3	+	14	1860	c.1775G>T	c.(1774-1776)gGg>gTg	p.G592V		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	592					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGTGGGATCGGGCTCAGTGCC	0.532000													32	55					6.50621e-10	8.94426e-10	0.769981	1	0
DMXL2	23312	broad.mit.edu	37	15	51856388	51856388	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:51856388T>A	ENST00000251076.5	-	5	721	c.434A>T	c.(433-435)gAg>gTg	p.E145V	DMXL2_ENST00000449909.3_Missense_Mutation_p.E145V|DMXL2_ENST00000560421.1_5'UTR|DMXL2_ENST00000543779.2_Missense_Mutation_p.E145V	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	145						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TTCTTCCTCCTCTTCCAGAAT	0.338000													15	27					0	0	0.479597	0	0
COL4A1	1282	broad.mit.edu	37	13	110864811	110864811	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:110864811C>G	ENST00000375820.4	-	6	461	c.340G>C	c.(340-342)Gac>Cac	p.D114H	COL4A1_ENST00000543140.1_Missense_Mutation_p.D114H	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	114					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGCGGGCCGTCTTGGCCAGGA	0.458000													23	2421					0	0	0.335167	0	0
KRTAP9-8	83901	broad.mit.edu	37	17	39394523	39394523	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:39394523C>A	ENST00000254072.6	+	1	227	c.220C>A	c.(220-222)Ccc>Acc	p.P74T		NM_031963.2	NP_114169.2	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9-8	74	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				lung(8)|ovary(1)|prostate(1)	10		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CTGCAGCACACCCTGCTGTCA	0.612000													24	64					1.66031e-10	2.3336e-10	0.667858	1	0
ACER2	340485	broad.mit.edu	37	9	19423859	19423859	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:19423859G>T	ENST00000340967.2	+	2	134		c.e2-1		ACER2_ENST00000380376.1_Splice_Site	NM_001010887.2	NP_001010887.2	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2						ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	13						TTTTCCTGCAGATCAGCAATG	0.378000													40	73					4.01765e-15	6.42415e-15	0.847076	1	0
CYP4F22	126410	broad.mit.edu	37	19	15636270	15636270	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:15636270G>T	ENST00000269703.2	+	3	322	c.123G>T	c.(121-123)cgG>cgT	p.R41R	CYP4F22_ENST00000601005.2_Silent_p.R41R	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	41						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						TGCTGCTGCGGTTCCTGAGGC	0.657000													41	16					2.79147e-13	4.27117e-13	0.870114	1	0
ALOX12B	242	broad.mit.edu	37	17	7983633	7983633	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:7983633C>A	ENST00000319144.4	-	6	934	c.674G>T	c.(673-675)gGc>gTc	p.G225V	AC129492.6_ENST00000399413.3_Missense_Mutation_p.A105D	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	225	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GTCCAACAGGCCGCGGACTTT	0.602000										Multiple Myeloma(8;0.094)	OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	91	45					2.31008e-40	4.97434e-40	0.870114	1	0
CTAG2	30848	broad.mit.edu	37	X	153881654	153881654	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153881654G>T	ENST00000247306.4	-	1	199	c.136C>A	c.(136-138)Cgg>Agg	p.R46R	CTAG2_ENST00000369585.3_Silent_p.R46R	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	46	Gly-rich.					centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGCGCCCCGGGGACCTCTG	0.756000													5	2					3.59834e-05	4.08202e-05	0.217242	1	0
NPRL3	8131	broad.mit.edu	37	16	142603	142603	+	Silent	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:142603A>G	ENST00000399953.3	-	10	1554	c.1152T>C	c.(1150-1152)gcT>gcC	p.A384A	NPRL3_ENST00000405960.3_5'UTR|NPRL3_ENST00000399951.3_Silent_p.A205A	NM_001077350.2|NM_001243247.1|NM_001243248.1|NM_001243249.1	NP_001070818.1|NP_001230176.1|NP_001230177.1|NP_001230178.1	Q12980	NPRL3_HUMAN	nitrogen permease regulator-like 3 (S. cerevisiae)	384							protein binding			endometrium(1)|large_intestine(3)|ovary(2)	6						CCTCCTGCACAGCGGGGGCCA	0.567000													4	24					0	0	0.150653	0	0
LTK	4058	broad.mit.edu	37	15	41803403	41803403	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:41803403C>A	ENST00000263800.6	-	7	1052	c.956G>T	c.(955-957)gGc>gTc	p.G319V	LTK_ENST00000453182.2_Intron|LTK_ENST00000561619.1_Intron|LTK_ENST00000355166.5_Intron	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	319					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		gcaggccccgccgccgccccc	0.761000										TSP Lung(18;0.14)			5	3					0.000602214	0.000654747	0.184627	1	0
SPATA19	219938	broad.mit.edu	37	11	133712000	133712000	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:133712000G>C	ENST00000299140.3	-	6	492	c.437_splice	c.e6-1	p.S146_splice	SPATA19_ENST00000532889.1_Splice_Site_p.S146_splice	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	146					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GACGGGATATGCTGCAGGGGA	0.607000													39	36					0	0	0.847076	0	0
INPP4B	8821	broad.mit.edu	37	4	143235911	143235911	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:143235911C>G	ENST00000513000.1	-	9	810	c.377G>C	c.(376-378)cGa>cCa	p.R126P	INPP4B_ENST00000262992.4_Missense_Mutation_p.R126P|INPP4B_ENST00000508116.1_Missense_Mutation_p.R126P|INPP4B_ENST00000509777.1_Missense_Mutation_p.R126P|INPP4B_ENST00000308502.4_Missense_Mutation_p.R126P	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	126	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					GACACTGGTTCGAACCTGTGG	0.448000													17	159					0	0	0.557998	0	0
EXTL3	2137	broad.mit.edu	37	8	28573992	28573992	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:28573992A>T	ENST00000220562.4	+	3	1318	c.416A>T	c.(415-417)gAg>gTg	p.E139V	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	139						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		AGCCAGACCGAGCATTCCTAC	0.577000													14	11					0	0	0.479597	0	0
TMTC2	160335	broad.mit.edu	37	12	83358821	83358821	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:83358821G>C	ENST00000549919.1	+	6	3404	c.1599G>C	c.(1597-1599)gaG>gaC	p.E533D	TMTC2_ENST00000548305.1_Missense_Mutation_p.E539D|TMTC2_ENST00000321196.3_Missense_Mutation_p.E539D			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	539						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						TTCTCCAGGAGAACAGCAGGT	0.338000													23	39					0	0	0.693898	0	0
STRN	6801	broad.mit.edu	37	2	37143295	37143295	+	Splice_Site	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:37143295C>G	ENST00000263918.4	-	3	347		c.e3-1		STRN_ENST00000379213.2_Splice_Site	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein						dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GTATTTGGCTCTAACAAAGAA	0.338000													7	38					0	0	0.307466	0	0
TMTC1	83857	broad.mit.edu	37	12	29689067	29689067	+	Nonsense_Mutation	SNP	G	G	T	rs71450781		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:29689067G>T	ENST00000381224.2	-	13	2195	c.1722C>A	c.(1720-1722)taC>taA	p.Y574*	TMTC1_ENST00000539277.1_Intron|TMTC1_ENST00000551659.1_Intron|TMTC1_ENST00000256062.5_Intron|TMTC1_ENST00000552618.1_Intron|TMTC1_ENST00000319685.8_Intron			Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	0						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					tAAATCATTAGTACAAAAATC	0.308000													4	5					0.00909568	0.00946796	0.150653	1	0
IL1RAP	3556	broad.mit.edu	37	3	190347153	190347153	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:190347153G>C	ENST00000412504.2	+	8	1169	c.917G>C	c.(916-918)aGa>aCa	p.R306T	IL1RAP_ENST00000422940.1_Missense_Mutation_p.R306T|IL1RAP_ENST00000434491.1_Missense_Mutation_p.R165T|IL1RAP_ENST00000439062.1_Missense_Mutation_p.R306T|IL1RAP_ENST00000317757.3_Missense_Mutation_p.R306T|IL1RAP_ENST00000443369.2_Missense_Mutation_p.R306T|IL1RAP_ENST00000072516.3_Missense_Mutation_p.R306T|IL1RAP_ENST00000422485.1_Missense_Mutation_p.R306T|IL1RAP_ENST00000447382.1_Missense_Mutation_p.R306T			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	306	Ig-like C2-type 3.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AGTCATAGTAGAACAGAAGAT	0.403000													5	31					0	0	0.278610	0	0
MUC6	4588	broad.mit.edu	37	11	1015781	1015781	+	Silent	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:1015781T>C	ENST00000421673.2	-	31	7070	c.7020A>G	c.(7018-7020)acA>acG	p.T2340T		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	2340	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGGCGTAGGTGTCCCGAGAG	0.632000													6	31					0	0	0.217242	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950602	235950602	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:235950602G>A	ENST00000409212.1	+	4	1696	c.1189G>A	c.(1189-1191)Gtg>Atg	p.V397M	SH3BP4_ENST00000392011.2_Missense_Mutation_p.V397M|SH3BP4_ENST00000344528.4_Missense_Mutation_p.V397M			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	397					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGAGATGAAAGTGTCAGCCGA	0.532000													15	21					0	0	0.520397	0	0
INTS3	65123	broad.mit.edu	37	1	153740181	153740181	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:153740181G>T	ENST00000456435.1	+	21	2690	c.1504G>T	c.(1504-1506)Gag>Tag	p.E502*	INTS3_ENST00000318967.2_Nonsense_Mutation_p.E708*|INTS3_ENST00000512605.1_Nonsense_Mutation_p.E502*|INTS3_ENST00000435409.2_Nonsense_Mutation_p.E708*|INTS3_ENST00000476843.1_3'UTR			Q68E01	INT3_HUMAN	integrator complex subunit 3	709					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAACCTGTACGAGTCATTTGC	0.622000													8	159					1.76689e-08	2.28857e-08	0.335167	1	0
STAB2	55576	broad.mit.edu	37	12	104078815	104078815	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:104078815G>T	ENST00000388887.2	+	27	3154	c.2950G>T	c.(2950-2952)Gag>Tag	p.E984*		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	984	EGF-like 10.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGTTTGTCAAGAGGGCTATGA	0.423000													46	112					1.47633e-17	2.51216e-17	0.870114	1	0
LONRF2	164832	broad.mit.edu	37	2	100919430	100919430	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:100919430G>A	ENST00000393437.3	-	3	1513	c.874C>T	c.(874-876)Ctt>Ttt	p.L292F	LONRF2_ENST00000409647.1_Missense_Mutation_p.L49F	NM_198461.3	NP_940863.3	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger 2	292					proteolysis		ATP-dependent peptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	34						TTCAGAGCAAGGCAGTAGAGA	0.393000													24	78					0	0	0.624587	0	0
CSRNP2	81566	broad.mit.edu	37	12	51461560	51461560	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:51461560C>G	ENST00000228515.1	-	4	901	c.604G>C	c.(604-606)Gaa>Caa	p.E202Q		NM_030809.2	NP_110436.1	Q9H175	CSRN2_HUMAN	cysteine-serine-rich nuclear protein 2	202					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	14						GCTCGAAGTTCTTGCTTCTCT	0.567000													19	66					0	0	0.608945	0	0
MYO15A	51168	broad.mit.edu	37	17	18022482	18022482	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:18022482G>T	ENST00000205890.5	+	2	706	c.368G>T	c.(367-369)cGc>cTc	p.R123L		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	123	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CTGCGGCCGCGCGCCCGGTCA	0.637000													7	16					8.12818e-05	9.07848e-05	0.248553	1	0
DCDC1	341019	broad.mit.edu	37	11	30944108	30944108	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:30944108C>G	ENST00000597505.1	-	22	3074	c.3075G>C	c.(3073-3075)agG>agC	p.R1025S	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.R104S			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ATTCTAGGTTCCTCAGGAATA	0.353000													10	33					0	0	0.457914	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043262	71043262	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:71043262G>A	ENST00000272367.2	-	4	1327	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	CLEC4F_ENST00000426626.1_Silent_p.A417A	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	417					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TCTCGGCACTGGCCTTCTGCA	0.493000													12	28					0	0	0.411799	0	0
GALNT2	2590	broad.mit.edu	37	1	230381896	230381896	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:230381896G>T	ENST00000366672.4	+	8	889	c.817_splice	c.e8+1	p.G273_splice	GALNT2_ENST00000543760.1_Splice_Site_p.G235_splice|GALNT2_ENST00000541865.1_Splice_Site_p.G183_splice	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	273					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CTTGAAGGGCGGTAGGTGTCT	0.507000													7	105					0.000157383	0.000174438	0.278610	1	0
GCLC	2729	broad.mit.edu	37	6	53370601	53370601	+	Splice_Site	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:53370601C>A	ENST00000229416.6	-	11	1773	c.1290_splice	c.e11+1	p.E430_splice	RP1-27K12.4_ENST00000508884.1_RNA	NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	430					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TGTGTCTTACCTCCATGGGTC	0.423000													67	102					1.8615e-32	3.82461e-32	0.870114	1	0
FGF23	8074	broad.mit.edu	37	12	4479833	4479833	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:4479833G>T	ENST00000237837.1	-	3	577	c.432C>A	c.(430-432)gcC>gcA	p.A144A		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	144					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CTGGCAGGAAGGCTCTCTTCG	0.587000													42	66					3.76525e-18	6.48919e-18	0.870114	1	0
RAB40A	142684	broad.mit.edu	37	X	102755633	102755633	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:102755633G>A	ENST00000372633.1	-	1	2170	c.52C>T	c.(52-54)Ctg>Ttg	p.L18L	RAB40A_ENST00000304236.1_Silent_p.L18L			Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	18					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	12						CCCACCAGCAGGAACTTGAGC	0.672000													21	148					0	0	0.667858	0	0
LILRP2	79166	broad.mit.edu	37	19	55221727	55221727	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:55221727G>T	ENST00000413439.1	+	0	1415																											TGAGGGGTGGGGGTCCCAAGG	0.642000													14	5					0.000151284	0.000168372	0.435327	1	0
DCHS1	8642	broad.mit.edu	37	11	6652389	6652389	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:6652389A>T	ENST00000299441.3	-	9	4236	c.3825T>A	c.(3823-3825)acT>acA	p.T1275T	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1275	Cadherin 12.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGAGCTGCAGTGAGCAGCT	0.632000													5	13					0	0	0.184627	0	0
AMER1	139285	broad.mit.edu	37	X	63412879	63412879	+	Missense_Mutation	SNP	G	G	T	rs112308756		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:63412879G>T	ENST00000330258.3	-	2	560	c.288C>A	c.(286-288)caC>caA	p.H96Q	AMER1_ENST00000374869.3_Missense_Mutation_p.H96Q|AMER1_ENST00000403336.1_Missense_Mutation_p.H96Q	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TCAGGCCATCGTGGGTCTTGC	0.537000													10	38					5.50884e-06	6.43952e-06	0.411799	1	0
FBXO34	55030	broad.mit.edu	37	14	55818034	55818034	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:55818034G>A	ENST00000313833.4	+	2	1171	c.926G>A	c.(925-927)cGt>cAt	p.R309H	FBXO34_ENST00000440021.1_Missense_Mutation_p.R309H	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	309										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						AACAGCTTCCGTCGAAATGTG	0.537000													19	120					0	0	0.608945	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604693	140604693	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140604693C>A	ENST00000239449.4	+	1	1616	c.1616C>A	c.(1615-1617)cCg>cAg	p.P539Q	PCDHB14_ENST00000515856.2_Missense_Mutation_p.P386Q	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		539	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGGGTCCCCGGCGTTGAGC	0.672000													23	24					3.73808e-20	6.73857e-20	0.693898	1	0
KIAA1244	57221	broad.mit.edu	37	6	138584486	138584486	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:138584486G>T	ENST00000251691.4	+	12	2032	c.1866G>T	c.(1864-1866)tcG>tcT	p.S622S		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	622	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity	p.S551S(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AAAAGGACTCGGGCAGGTCCG	0.527000													67	112					5.01443e-46	1.10376e-45	0.870114	1	0
OPN1LW	5956	broad.mit.edu	37	X	153421925	153421925	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:153421925C>A	ENST00000369951.4	+	5	961	c.901C>A	c.(901-903)Cct>Act	p.P301T		NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	301					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGCCTTCCACCCTTTGATGGC	0.542000													74	586					3.00245e-22	5.58913e-22	0.870114	1	0
SNRNP40	9410	broad.mit.edu	37	1	31742092	31742092	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:31742092A>T	ENST00000373720.3	-	1	421	c.81T>A	c.(79-81)ttT>ttA	p.F27L	SNRNP40_ENST00000263694.4_Intron|SNRNP40_ENST00000489853.1_Intron|SNRNP40_ENST00000446633.2_Intron			Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	0						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						CACGAACTGCAAAACAAATCC	0.438000													18	50					0	0	0.575678	0	0
SALL4	57167	broad.mit.edu	37	20	50408418	50408418	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:50408418G>A	ENST00000217086.4	-	2	715	c.604C>T	c.(604-606)Cct>Tct	p.P202S	SALL4_ENST00000371539.3_Intron|SALL4_ENST00000395997.3_Missense_Mutation_p.P202S	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	202					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACGGGGGCAGGGAGTGCATCC	0.592000													83	170					0	0	0.870114	0	0
RELN	5649	broad.mit.edu	37	7	103237094	103237094	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:103237094C>T	ENST00000428762.1	-	25	3507	c.3348G>A	c.(3346-3348)caG>caA	p.Q1116Q	RELN_ENST00000343529.5_Silent_p.Q1116Q|RELN_ENST00000424685.2_Silent_p.Q1116Q	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1116					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTCACCAGCTGTCTTTTCC	0.443000													23	37					0	0	0.740014	0	0
CDH7	1005	broad.mit.edu	37	18	63481754	63481754	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:63481754C>G	ENST00000536984.2	+	4	1233	c.539C>G	c.(538-540)gCt>gGt	p.A180G	CDH7_ENST00000323011.3_Missense_Mutation_p.A180G|CDH7_ENST00000397968.2_Missense_Mutation_p.A180G			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	180	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GCGACGGATGCTGATGATCCT	0.428000													17	77					0	0	0.557998	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027553	9027553	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:9027553C>A	ENST00000383836.3	-	22	3377	c.2950G>T	c.(2950-2952)Gtc>Ttc	p.V984F	SRGAP3_ENST00000360413.3_Missense_Mutation_p.V960F	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	984					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GCCTGCTTGACCGTGTTCTGC	0.642000			T	RAF1	pilocytic astrocytoma								3	28					0.00909568	0.00946796	0.150653	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72176379	72176379	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:72176379A>T	ENST00000555818.1	+	15	4617	c.4269A>T	c.(4267-4269)acA>acT	p.T1423T	SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000381232.3_Silent_p.T1402T|SIPA1L1_ENST00000537413.1_Silent_p.T877T|SIPA1L1_ENST00000358550.2_Silent_p.T1402T	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1423	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTTCCCACACAAGGTAACCAC	0.532000													12	32					0	0	0.457914	0	0
PKHD1	5314	broad.mit.edu	37	6	51497494	51497494	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:51497494G>T	ENST00000371117.3	-	65	11809	c.11534C>A	c.(11533-11535)cCa>cAa	p.P3845Q		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3845					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GACAGCAAATGGCTTGGATCG	0.443000													7	54					1.76689e-08	2.28857e-08	0.335167	1	0
ATP13A5	344905	broad.mit.edu	37	3	193044810	193044810	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:193044810C>A	ENST00000342358.4	-	13	1615	c.1498G>T	c.(1498-1500)Ggg>Tgg	p.G500W		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	500					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GGGACAGTCCCCCAGAGGTCC	0.393000													6	73					0.000442599	0.00048485	0.335167	1	0
TPP1	1200	broad.mit.edu	37	11	6637571	6637571	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:6637571C>A	ENST00000533371.1	-	7	1119	c.321G>T	c.(319-321)cgG>cgT	p.R107R	TPP1_ENST00000299427.6_Silent_p.R350R			O14773	TPP1_HUMAN	tripeptidyl peptidase I	350					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		GGGTGAGACCCCGAGCGGCAG	0.562000													30	83					9.62906e-15	1.52413e-14	0.819951	1	0
GPR137C	283554	broad.mit.edu	37	14	53066848	53066848	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:53066848G>T	ENST00000321662.6	+	3	506	c.506G>T	c.(505-507)gGc>gTc	p.G169V		NM_001099652.1	NP_001093122.1	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	169						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8	Breast(41;0.0716)					CTGCATTTGGGCTTTATAATG	0.338000													39	73					9.39024e-22	1.7377e-21	0.847076	1	0
AKIRIN2	55122	broad.mit.edu	37	6	88391356	88391356	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:88391356T>A	ENST00000257787.5	-	2	885	c.361A>T	c.(361-363)Agt>Tgt	p.S121C		NM_018064.3	NP_060534.1	Q53H80	AKIR2_HUMAN	akirin 2	121					innate immune response|transcription, DNA-dependent	transcriptional repressor complex				large_intestine(4)	4						GCTGGTCCACTGAGGAGAAAT	0.378000													15	12					0	0	0.575678	0	0
FOXF2	2295	broad.mit.edu	37	6	1391252	1391252	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:1391252C>A	ENST00000259806.1	+	1	1184	c.1070C>A	c.(1069-1071)cCc>cAc	p.P357H		NM_001452.1	NP_001443.1	Q12947	FOXF2_HUMAN	forkhead box F2	357					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			large_intestine(2)|lung(5)|prostate(1)	8	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		GCCCTGACGCCCAGCAGCAAC	0.682000													7	16					0.0293803	0.0301822	0.248553	1	0
KLC2	64837	broad.mit.edu	37	11	66031903	66031903	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:66031903G>T	ENST00000394065.2	+	7	1805	c.787G>T	c.(787-789)Ggc>Tgc	p.G263C	KLC2_ENST00000421552.1_Missense_Mutation_p.G325C|KLC2_ENST00000417856.1_Missense_Mutation_p.G402C|KLC2_ENST00000316924.5_Missense_Mutation_p.G402C|KLC2_ENST00000394066.2_Missense_Mutation_p.G325C|KLC2_ENST00000394067.2_Missense_Mutation_p.G402C|KLC2_ENST00000394078.1_Intron			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	402					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						GAAAGAGTTTGGCTCTGTCAA	0.587000													6	30					1.12685e-05	1.30266e-05	0.307466	1	0
DCAF6	55827	broad.mit.edu	37	1	168034950	168034950	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:168034950G>T	ENST00000367840.3	+	19	2656	c.2562G>T	c.(2560-2562)gtG>gtT	p.V854V	DCAF6_ENST00000432587.2_Silent_p.V823V|DCAF6_ENST00000367843.3_Silent_p.V783V|DCAF6_ENST00000312263.6_Silent_p.V763V	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	763					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						ATAATCATGTGGTAAACTGCC	0.423000													28	95					4.31634e-10	5.97305e-10	0.760397	1	0
TMEM261	90871	broad.mit.edu	37	9	7799591	7799591	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr9:7799591C>A	ENST00000358227.4	-	1	476	c.144G>T	c.(142-144)tgG>tgT	p.W48C	C9orf123_ENST00000484082.1_Intron	NM_033428.1	NP_219500.1	Q96GE9	CI123_HUMAN		48						integral to membrane				lung(1)	1		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		CGCGACAGCTCCAGCAGGTCT	0.687000													54	78					1.49552e-23	2.83727e-23	0.870114	1	0
ID3	3399	broad.mit.edu	37	1	23885763	23885763	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:23885763C>A	ENST00000374561.5	-	1	522	c.155G>T	c.(154-156)cGg>cTg	p.R52L	ID3_ENST00000486541.1_5'UTR	NM_002167.4	NP_002158.3	Q02535	ID3_HUMAN	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	52	Helix-loop-helix motif.				negative regulation of sequence-specific DNA binding transcription factor activity		transcription corepressor activity			central_nervous_system(1)|lung(3)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00314)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;8.83e-25)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;6.5e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TACCAGTTCCCGCAGGCGGGA	0.642000													40	64					2.68985e-26	5.24591e-26	0.870114	1	0
AGMO	392636	broad.mit.edu	37	7	15433748	15433748	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:15433748C>A	ENST00000342526.3	-	6	835	c.666G>T	c.(664-666)agG>agT	p.R222S	AGMO_ENST00000498264.1_5'UTR	NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	222					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						CATGATGAACCCTATGATGGC	0.303000													45	83					1.13709e-37	2.42356e-37	0.870114	1	0
RP9	6100	broad.mit.edu	37	7	33134984	33134984	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:33134984G>T	ENST00000297157.3	-	6	545	c.528C>A	c.(526-528)tcC>tcA	p.S176S		NM_203288.1	NP_976033.1	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9 (autosomal dominant)	176	Poly-Ser.				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding			large_intestine(3)|lung(3)|urinary_tract(1)	7			GBM - Glioblastoma multiforme(11;0.0403)			CAGAGGAACTGGAGCTGCTCC	0.353000													15	42					3.99206e-14	6.25046e-14	0.557998	1	0
MUC16	94025	broad.mit.edu	37	19	8971716	8971716	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:8971716C>G	ENST00000397910.4	-	78	43079	c.42876G>C	c.(42874-42876)tgG>tgC	p.W14292C	MUC16_ENST00000380951.5_Missense_Mutation_p.W933C	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14375	SEA 15.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAGCCCAGCCAATGGAATG	0.527000													35	18					0	0	0.812448	0	0
PTPRR	5801	broad.mit.edu	37	12	71077924	71077924	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:71077924G>T	ENST00000283228.2	-	10	1932	c.1480C>A	c.(1480-1482)Ctc>Atc	p.L494I	PTPRR_ENST00000342084.4_Missense_Mutation_p.L382I|PTPRR_ENST00000378778.1_Missense_Mutation_p.L288I|PTPRR_ENST00000440835.2_Missense_Mutation_p.L249I|PTPRR_ENST00000549308.1_Missense_Mutation_p.L249I	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	494	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TTTTCTTTGAGTTTTGTGATC	0.408000													7	36					1.12685e-05	1.30266e-05	0.307466	1	0
OR3A1	4994	broad.mit.edu	37	17	3195679	3195679	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:3195679C>T	ENST00000323404.1	-	1	197	c.198G>A	c.(196-198)ctG>ctA	p.L66L	RP11-64J4.2_ENST00000573491.1_RNA	NM_002550.2	NP_002541.2	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A, member 1	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	20						ATAGGTTCCCCAGGAAGAAGT	0.572000													16	33					0	0	0.557998	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110447583	110447583	+	Splice_Site	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:110447583G>C	ENST00000378402.5	+	29	3609	c.3505_splice	c.e29+1	p.G1169_splice		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1169	IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAGCATAGCAGGTAATGGTTA	0.423000										HNSCC(38;0.096)			44	180					0	0	0.870114	0	0
COL4A2	1284	broad.mit.edu	37	13	111077199	111077199	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:111077199G>T	ENST00000360467.5	+	5	605	c.299G>T	c.(298-300)gGa>gTa	p.G100V		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	100					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGAGTAACGGGACCCAAGGGC	0.587000													10	683					9.05144e-12	1.33189e-11	0.435327	1	0
IFRD2	7866	broad.mit.edu	37	3	50330259	50330259	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:50330259C>T	ENST00000336089.4	-	2	45	c.46G>A	c.(46-48)Gag>Aag	p.E16K	IFRD2_ENST00000436390.1_5'UTR			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	228							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AGCCAAACCTCAGGCAGTGGA	0.542000													8	39					0	0	0.307466	0	0
POTEE	445582	broad.mit.edu	37	2	132010559	132010559	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:132010559C>G	ENST00000356920.5	+	13	1759	c.1665C>G	c.(1663-1665)aaC>aaG	p.N555K	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	555							ATP binding										TCCCAGAAAACCTGACTAATG	0.413000													8	47					0	0	0.361761	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842749	22842749	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr22:22842749C>A	ENST00000360412.2	-	4	1750	c.975G>T	c.(973-975)gtG>gtT	p.V325V	ZNF280B_ENST00000406426.1_Silent_p.V325V	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AATGATGCTTCACGTGATTCA	0.483000													49	95					1.46156e-29	2.94187e-29	0.870114	1	0
COL1A1	1277	broad.mit.edu	37	17	48275138	48275138	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:48275138C>A	ENST00000225964.5	-	9	769	c.651G>T	c.(649-651)atG>atT	p.M217I		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	217	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CTCGGGGACCCATGGGACCCT	0.517000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						40	72					7.05121e-23	1.32571e-22	0.853193	1	0
NCKAP1	10787	broad.mit.edu	37	2	183850938	183850938	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:183850938T>C	ENST00000360982.2	-	11	1741	c.983A>G	c.(982-984)aAt>aGt	p.N328S	NCKAP1_ENST00000361354.3_Missense_Mutation_p.N322S	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	322					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCTTATGTCATTAATACGTTT	0.313000													18	30					0	0	0.608945	0	0
SMURF1	57154	broad.mit.edu	37	7	98645414	98645414	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:98645414C>T	ENST00000361125.1	-	11	1442	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	SMURF1_ENST00000361368.2_Missense_Mutation_p.E349K|AC004893.11_ENST00000482799.2_RNA|AC004893.11_ENST00000468960.2_RNA	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	375					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			AGATCTCTTTCGTATCTCTGG	0.562000													50	188					0	0	0.870114	0	0
ISL1	3670	broad.mit.edu	37	5	50685659	50685659	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:50685659C>T	ENST00000230658.7	+	4	1243	c.658C>T	c.(658-660)Ctc>Ttc	p.L220F	ISL1_ENST00000511384.1_Missense_Mutation_p.L220F|ISL1_ENST00000505475.2_3'UTR	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	220					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GATGACGGGCCTCAGTCCCCG	0.572000													18	17					0	0	0.592651	0	0
TRRAP	8295	broad.mit.edu	37	7	98556987	98556987	+	Silent	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:98556987A>T	ENST00000359863.4	+	44	6551	c.6342A>T	c.(6340-6342)acA>acT	p.T2114T	TRRAP_ENST00000355540.3_Silent_p.T2096T|TRRAP_ENST00000446306.3_Silent_p.T2095T	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2114	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACACCAACACAGCGGGGTCCC	0.547000													27	94					0	0	0.740014	0	0
GLUD2	2747	broad.mit.edu	37	X	120182832	120182832	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:120182832G>C	ENST00000328078.1	+	1	1371	c.1294G>C	c.(1294-1296)Gct>Cct	p.A432P		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	432					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTACTTGAATGCTGGAGGAGT	0.418000													15	139					0	0	0.520397	0	0
FRS2	10818	broad.mit.edu	37	12	69966000	69966000	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:69966000G>C	ENST00000299293.2	+	9	1025	c.515G>C	c.(514-516)aGt>aCt	p.S172T	FRS2_ENST00000549921.1_Missense_Mutation_p.S172T|FRS2_ENST00000397997.2_Missense_Mutation_p.S172T|FRS2_ENST00000550389.1_Missense_Mutation_p.S172T	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	172					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCTGTGGGAAGTGCTCGCCTG	0.468000													44	94					0	0	0.870114	0	0
PKHD1	5314	broad.mit.edu	37	6	51497495	51497495	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:51497495G>T	ENST00000371117.3	-	65	11808	c.11533C>A	c.(11533-11535)Cca>Aca	p.P3845T		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3845					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACAGCAAATGGCTTGGATCGA	0.438000													7	54					1.76689e-08	2.28857e-08	0.335167	1	0
TREML3P	340206	broad.mit.edu	37	6	41177456	41177456	+	RNA	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:41177456G>A	ENST00000564680.1	-	0	416																											GGCAGATGGGGGCACTTGATT	0.587000													3	7					0	0	0.115264	0	0
HDAC9	9734	broad.mit.edu	37	7	19015542	19015542	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:19015542G>T	ENST00000406451.3	+	25	3277	c.3127G>T	c.(3127-3129)Gat>Tat	p.D1043Y	HDAC9_ENST00000401921.1_Missense_Mutation_p.D1002Y|HDAC9_ENST00000441542.2_Missense_Mutation_p.D1046Y	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	0					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTAACAGTGGATGTGGAACA	0.537000													16	40					3.41278e-10	4.73662e-10	0.520397	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113519092	113519092	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:113519092C>A	ENST00000284601.3	-	4	2123	c.2055G>T	c.(2053-2055)gtG>gtT	p.V685V		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	685					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTTTTCCCCACACGTCTTCAC	0.383000													48	196					1.48873e-21	2.74954e-21	0.870114	1	0
FBXL7	23194	broad.mit.edu	37	5	15928310	15928310	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:15928310C>A	ENST00000504595.1	+	3	920	c.439C>A	c.(439-441)Ctg>Atg	p.L147M	FBXL7_ENST00000510662.1_Missense_Mutation_p.L100M|FBXL7_ENST00000329673.7_Missense_Mutation_p.L135M	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	147	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CTGGTACAACCTGGCCTGGGA	0.667000													6	15					0.00198382	0.00212133	0.248553	1	0
GJD2	57369	broad.mit.edu	37	15	35044798	35044798	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:35044798C>A	ENST00000290374.4	-	2	1323	c.847G>T	c.(847-849)Gct>Tct	p.A283S		NM_020660.2	NP_065711.1	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	283					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		CCTCGCACAGCCAGCTTGATC	0.507000													42	30					1.07234e-20	1.95179e-20	0.870114	1	0
RHAG	6005	broad.mit.edu	37	6	49574909	49574909	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:49574909T>A	ENST00000229810.7	-	7	996	c.970A>T	c.(970-972)Act>Tct	p.T324S	RHAG_ENST00000371175.4_Silent_p.A364A			Q02094	RHAG_HUMAN	Rh-associated glycoprotein	0					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					AGGAACCCAGTGCAGCTGCCT	0.453000													15	18					0	0	0.557998	0	0
TEX13B	56156	broad.mit.edu	37	X	107224763	107224763	+	Silent	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:107224763G>T	ENST00000302917.1	-	3	578	c.486C>A	c.(484-486)ggC>ggA	p.G162G		NM_031273.2	NP_112563.1	Q9BXU2	TX13B_HUMAN	testis expressed 13B	162										breast(1)|endometrium(5)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28						CTGTAGCCTGGCCCTGTCCCT	0.642000													16	144					3.52763e-06	4.165e-06	0.520397	1	0
CIT	11113	broad.mit.edu	37	12	120221827	120221827	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:120221827C>A	ENST00000392521.2	-	12	1485	c.1430G>T	c.(1429-1431)cGg>cTg	p.R477L	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.R477L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	477					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGACACTCTCCGATGTAACCG	0.517000													58	174					9.12251e-31	1.85406e-30	0.870114	1	0
TBX22	50945	broad.mit.edu	37	X	79281106	79281106	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:79281106G>T	ENST00000442340.1	+	5	593	c.103G>T	c.(103-105)Gtc>Ttc	p.V35F	TBX22_ENST00000373291.1_Missense_Mutation_p.V35F|TBX22_ENST00000373294.5_Missense_Mutation_p.V155F|TBX22_ENST00000373296.3_Missense_Mutation_p.V155F	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	155					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.V155L(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTTCAGGTACGTCTATCACAG	0.507000													8	44					7.48243e-07	9.12042e-07	0.335167	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32893883	32893883	+	RNA	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:32893883C>A	ENST00000330048.5	-	0	1374					NR_003083.2																						GACTGGCGGTCAGCAAGCTGG	0.612000													29	87					3.54561e-26	6.89342e-26	0.847076	1	0
RIMS2	9699	broad.mit.edu	37	8	104898340	104898340	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:104898340G>T	ENST00000507740.1	+	2	1173	c.937G>T	c.(937-939)Ggt>Tgt	p.G313C	RIMS2_ENST00000436393.2_Missense_Mutation_p.G283C|RIMS2_ENST00000262231.10_Missense_Mutation_p.G313C|RIMS2_ENST00000406091.3_Missense_Mutation_p.G505C	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	536					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.G313S(1)|p.G541S(1)|p.G283S(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAGAAAGGCGGTAAAATGCG	0.428000										HNSCC(12;0.0054)			19	45					1.96292e-10	2.74459e-10	0.592651	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090364	238090364	+	RNA	SNP	T	T	A	rs28482009		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:238090364T>A	ENST00000450451.1	+	0	1870					NR_027247.2																						CGTCACCAACTGGGACGACAT	0.612000													19	47					0	0	0.608945	0	0
MUC7	4589	broad.mit.edu	37	4	71347339	71347339	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:71347339C>T	ENST00000413702.1	+	4	1166	c.878C>T	c.(877-879)gCt>gTt	p.A293V	MUC7_ENST00000304887.5_Missense_Mutation_p.A293V|MUC7_ENST00000456088.1_Missense_Mutation_p.A293V	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	293	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACTACACCAGCTCCACCGTCT	0.557000													37	135					0	0	0.870114	0	0
STON2	85439	broad.mit.edu	37	14	81862427	81862427	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:81862427C>A	ENST00000555447.1	-	4	596	c.184G>T	c.(184-186)Gac>Tac	p.D62Y	STON2_ENST00000267540.2_Missense_Mutation_p.D62Y	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	62					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGGGAATGGTCTTGAGAGCCT	0.607000													26	39					7.07758e-08	8.97574e-08	0.681144	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102481464	102481464	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:102481464A>T	ENST00000360184.4	+	35	7201	c.7037A>T	c.(7036-7038)cAg>cTg	p.Q2346L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2346	AAA 2 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TTTGAGGTACAGGACTTGAAA	0.428000													21	160					0	0	0.654019	0	0
SORCS3	22986	broad.mit.edu	37	10	106982966	106982966	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:106982966G>T	ENST00000369701.3	+	20	3054	c.2827G>T	c.(2827-2829)Ggg>Tgg	p.G943W	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	943						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTCAACTGGGGACCCTTAC	0.463000													24	77					1.56442e-22	2.92959e-22	0.760397	1	0
OR5M3	219482	broad.mit.edu	37	11	56237685	56237685	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:56237685C>G	ENST00000312240.2	-	1	329	c.289G>C	c.(289-291)Gta>Cta	p.V97L		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AAACACTGTACTAAACAACCA	0.363000													30	56					0	0	0.729181	0	0
DGKB	1607	broad.mit.edu	37	7	14741333	14741333	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:14741333C>A	ENST00000403951.2	-	7	908	c.489G>T	c.(487-489)acG>acT	p.T163T	DGKB_ENST00000399322.3_Silent_p.T163T|DGKB_ENST00000258767.5_Silent_p.T163T|DGKB_ENST00000444700.2_Silent_p.T156T|DGKB_ENST00000402815.1_Silent_p.T163T|DGKB_ENST00000407950.1_Silent_p.T156T|DGKB_ENST00000406247.3_Silent_p.T163T|DGKB_ENST00000403963.1_5'UTR			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	163	EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CATTCCCATCCGTGTCATAAA	0.308000													23	49					1.99505e-19	3.53882e-19	0.760397	1	0
ZCCHC13	389874	broad.mit.edu	37	X	73524366	73524366	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:73524366C>A	ENST00000339534.2	+	1	342	c.265C>A	c.(265-267)Caa>Aaa	p.Q89K		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	89							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						AGAGAGACGCCAACACTGTTA	0.493000													10	38					1.58986e-06	1.90703e-06	0.361761	1	0
MYO16	23026	broad.mit.edu	37	13	109777688	109777688	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:109777688A>C	ENST00000356711.2	+	30	3824	c.3698A>C	c.(3697-3699)cAa>cCa	p.Q1233P	MYO16_ENST00000357550.2_Missense_Mutation_p.Q1233P|MYO16_ENST00000457511.2_Missense_Mutation_p.Q745P	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1233					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AGGAACATGCAAGAGGAAGGA	0.428000													192	39					0	0	0.870114	0	0
DTNA	1837	broad.mit.edu	37	18	32374067	32374067	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:32374067C>G	ENST00000283365.9	+	5	566	c.215C>G	c.(214-216)cCa>cGa	p.P72R	DTNA_ENST00000596745.1_Missense_Mutation_p.P72R|DTNA_ENST00000399113.3_Missense_Mutation_p.P72R|DTNA_ENST00000595022.1_Missense_Mutation_p.P72R|DTNA_ENST00000598142.1_Missense_Mutation_p.P72R|DTNA_ENST00000399121.5_Missense_Mutation_p.P72R|DTNA_ENST00000554864.3_Missense_Mutation_p.P72R|DTNA_ENST00000269190.7_Missense_Mutation_p.P72R|DTNA_ENST00000315456.6_Missense_Mutation_p.P72R|DTNA_ENST00000399097.3_5'UTR|DTNA_ENST00000348997.5_Missense_Mutation_p.P72R|DTNA_ENST00000597599.1_Missense_Mutation_p.P72R|DTNA_ENST00000269191.6_Missense_Mutation_p.P72R|DTNA_ENST00000598774.1_Missense_Mutation_p.P72R|DTNA_ENST00000444659.1_Missense_Mutation_p.P72R|DTNA_ENST00000598334.1_Missense_Mutation_p.P72R	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	72	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						AACCTGGACCCAAACACTGAA	0.468000													16	25					0	0	0.539581	0	0
OR51E2	81285	broad.mit.edu	37	11	4703939	4703939	+	Translation_Start_Site	SNP	C	C	A	rs148773103	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:4703939C>A	ENST00000396950.3	-	2	242	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGCAGGAACTCATAGCTGGAA	0.507000													28	26					2.48696e-23	4.69454e-23	0.779181	1	0
ELTD1	64123	broad.mit.edu	37	1	79403644	79403644	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:79403644T>A	ENST00000370742.3	-	6	671	c.608A>T	c.(607-609)cAa>cTa	p.Q203L		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	203					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TGTATCCCTTTGAACAAAATT	0.308000													15	53					0	0	0.539581	0	0
SLC4A11	83959	broad.mit.edu	37	20	3212166	3212166	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:3212166G>A	ENST00000380059.3	-	8	988	c.887C>T	c.(886-888)gCg>gTg	p.A296V	SLC4A11_ENST00000380056.3_Missense_Mutation_p.A269V|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.A253V	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	269					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						AAACGTGCGCGCCACCTCCAT	0.597000													32	71					0	0	0.819951	0	0
SYCP2L	221711	broad.mit.edu	37	6	10907786	10907786	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:10907786C>A	ENST00000283141.6	+	10	984	c.688C>A	c.(688-690)Cag>Aag	p.Q230K	RP11-637O19.3_ENST00000480294.1_3'UTR|SYCP2L_ENST00000543878.1_Missense_Mutation_p.Q71K	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	230						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TTATGACCAGCAGGTTGCTAT	0.358000													17	55					7.45023e-12	1.09971e-11	0.592651	1	0
SLC4A5	57835	broad.mit.edu	37	2	74460634	74460634	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:74460634C>A	ENST00000394019.2	-	23	2887	c.2490G>T	c.(2488-2490)tgG>tgT	p.W830C	SLC4A5_ENST00000377632.1_Missense_Mutation_p.W830C|SLC4A5_ENST00000377634.4_Missense_Mutation_p.W830C|SLC4A5_ENST00000359484.4_Missense_Mutation_p.W728C|SLC4A5_ENST00000358683.4_Missense_Mutation_p.W728C|SLC4A5_ENST00000357822.5_Missense_Mutation_p.W830C|SLC4A5_ENST00000346834.4_Missense_Mutation_p.W830C|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.W830C|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	830						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CTGGGTATACCCACCACGGGT	0.597000													19	72					3.62473e-10	5.01968e-10	0.608945	1	0
KIAA2022	340533	broad.mit.edu	37	X	73962862	73962862	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:73962862C>G	ENST00000373468.1	-	3	2181	c.1530G>C	c.(1528-1530)tgG>tgC	p.W510C	KIAA2022_ENST00000055682.5_Missense_Mutation_p.W510C			Q5QGS0	K2022_HUMAN	KIAA2022	510					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CAACTGGCAGCCATTCCTTCC	0.408000													3	8					0	0	0.115264	0	0
EPRS	2058	broad.mit.edu	37	1	220198587	220198587	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:220198587C>T	ENST00000366923.3	-	7	906	c.637G>A	c.(637-639)Ggg>Agg	p.G213R		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	213	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TTTGCATGCCCAATGTGTAAG	0.328000													7	26					0	0	0.278610	0	0
PHKA1	5255	broad.mit.edu	37	X	71864285	71864285	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:71864285C>T	ENST00000373545.3	-	14	1824	c.1386G>A	c.(1384-1386)gtG>gtA	p.V462V	PHKA1_ENST00000339490.3_Silent_p.V462V|PHKA1_ENST00000373542.4_Silent_p.V462V|PHKA1_ENST00000541944.1_Silent_p.V462V|PHKA1_ENST00000373539.3_Silent_p.V462V			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	462					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CAATGGTCTCCACGTAAATTC	0.428000													3	14					0	0	0.115264	0	0
RTTN	25914	broad.mit.edu	37	18	67697286	67697286	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:67697286C>G	ENST00000255674.6	-	42	5993	c.5707G>C	c.(5707-5709)Gat>Cat	p.D1903H	RTTN_ENST00000579986.1_5'UTR|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1903							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CTCAGAGAATCTAGGTTCAGT	0.383000													18	76					0	0	0.639603	0	0
GPC4	2239	broad.mit.edu	37	X	132548851	132548851	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:132548851G>T	ENST00000370828.3	-	1	667	c.143C>A	c.(142-144)cCc>cAc	p.P48H		NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	48					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					CTCGTGGAGGGGGGCATCGTT	0.642000													13	120					0.00244969	0.00261208	0.457914	1	0
GPR123	84435	broad.mit.edu	37	10	134940763	134940763	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:134940763C>A	ENST00000607359.1	+	15	2588	c.2588C>A	c.(2587-2589)cCc>cAc	p.P863H	GPR123_ENST00000392606.2_Missense_Mutation_p.P46H|GPR123_ENST00000392607.3_Missense_Mutation_p.P143H			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	143						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GGAGGGGTCCCCTTTATCATC	0.647000													10	11					0.00244969	0.00261208	0.457914	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68705678	68705678	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:68705678G>T	ENST00000255078.3	+	14	2751	c.2640G>T	c.(2638-2640)gaG>gaT	p.E880D		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	880					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGCCCACGGAGGAGGACTTTG	0.572000													34	85					2.77807e-22	5.17656e-22	0.864702	1	0
MCF2L	23263	broad.mit.edu	37	13	113740515	113740515	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:113740515G>A	ENST00000397030.1	+	21	2461	c.2424G>A	c.(2422-2424)ctG>ctA	p.L808L	MCF2L_ENST00000423482.2_Silent_p.L773L|MCF2L_ENST00000375604.2_Silent_p.L832L|MCF2L_ENST00000375608.3_Silent_p.L805L|MCF2L_ENST00000375597.4_Silent_p.L773L|MCF2L_ENST00000535094.2_Silent_p.L775L|MCF2L_ENST00000421756.1_Silent_p.L779L|MCF2L_ENST00000442652.2_Silent_p.L805L|MCF2L_ENST00000375601.3_Silent_p.L779L|MCF2L_ENST00000434480.2_Silent_p.L781L			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	805	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TGGGCATCCTGAAGGCCGTGA	0.617000													8	628					0	0	0.361761	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605138	140605138	+	Silent	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:140605138C>T	ENST00000239449.4	+	1	2061	c.2061C>T	c.(2059-2061)acC>acT	p.T687T	PCDHB14_ENST00000515856.2_Silent_p.T534T	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		687					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.T687T(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCCCTCACCGTCTACCTGG	0.706000													63	49					0	0	0.870114	0	0
EPS8	2059	broad.mit.edu	37	12	15819375	15819375	+	Splice_Site	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:15819375T>A	ENST00000281172.5	-	7	1034	c.599_splice	c.e7+1	p.R200_splice	EPS8_ENST00000543612.1_Splice_Site_p.R200_splice|EPS8_ENST00000543523.1_Splice_Site_p.R200_splice	NM_004447.5	NP_004438.3	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway substrate 8	200					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGCTTTTACCTCAGGGCGTCG	0.378000													8	40					0	0	0.335167	0	0
ACSBG1	23205	broad.mit.edu	37	15	78474871	78474871	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:78474871A>T	ENST00000258873.4	-	7	1036	c.831T>A	c.(829-831)tgT>tgA	p.C277*	ACSBG1_ENST00000560817.1_Nonsense_Mutation_p.C35*|ACSBG1_ENST00000541759.1_Nonsense_Mutation_p.C35*	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	277					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						AGACTAGCACACAGCACTGGT	0.587000													16	31					0	0	0.592651	0	0
HNF4G	3174	broad.mit.edu	37	8	76470801	76470801	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:76470801G>T	ENST00000396423.2	+	7	876	c.752G>T	c.(751-753)cGt>cTt	p.R251L	HNF4G_ENST00000354370.1_Missense_Mutation_p.R214L	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	214					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.R214L(1)|p.R251L(1)		breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GAGATTAGCCGTGTGGCCAAT	0.378000													31	181					2.91434e-09	3.9177e-09	0.804634	1	0
SNTG1	54212	broad.mit.edu	37	8	51306825	51306825	+	Splice_Site	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:51306825G>T	ENST00000522124.1	+	3	688	c.27_splice	c.e3+1	p.E9_splice	SNTG1_ENST00000276467.5_Splice_Site_p.E9_splice|SNTG1_ENST00000517473.1_Splice_Site_p.E9_splice|SNTG1_ENST00000518864.1_Splice_Site_p.E9_splice	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	9					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CCTGTGAGGAGGTGAGTACAG	0.443000													13	21					9.16793e-09	1.20321e-08	0.520397	1	0
KIRREL	55243	broad.mit.edu	37	1	158046020	158046020	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:158046020G>C	ENST00000368173.3	+	2	574	c.170G>C	c.(169-171)gGg>gCg	p.G57A	KIRREL_ENST00000416935.2_Intron|KIRREL_ENST00000392272.2_Missense_Mutation_p.G57A|KIRREL_ENST00000359209.6_Missense_Mutation_p.G57A|KIRREL_ENST00000360089.4_5'UTR	NM_018240.5	NP_060710.3	Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	57	Ig-like C2-type 1.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					ACCAAGGACGGGCTGGCCCTG	0.617000													16	130					0	0	0.575678	0	0
TDRD6	221400	broad.mit.edu	37	6	46660099	46660099	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:46660099C>G	ENST00000544460.1	+	1	4488	c.4234C>G	c.(4234-4236)Ccg>Gcg	p.P1412A	TDRD6_ENST00000316081.6_Missense_Mutation_p.P1412A	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1412					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGCAATATTGCCGGGGTTGTG	0.413000													99	147					0	0	0.870114	0	0
TACC2	10579	broad.mit.edu	37	10	123842969	123842969	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:123842969G>A	ENST00000369005.1	+	4	1294	c.954G>A	c.(952-954)ggG>ggA	p.G318G	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.G318G|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Silent_p.G318G|TACC2_ENST00000515273.1_Silent_p.G318G|TACC2_ENST00000453444.2_Silent_p.G318G	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	318						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCAATTCAGGGGCTGCCCCAG	0.597000													7	55					0	0	0.278610	0	0
NPR1	4881	broad.mit.edu	37	1	153659213	153659213	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:153659213G>T	ENST00000368680.3	+	11	2322	c.1850G>T	c.(1849-1851)cGt>cTt	p.R617L		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	617	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TACTGTCCCCGTGGGAGCCTG	0.607000													23	99					1.96895e-08	2.54503e-08	0.639603	1	0
B3GNT7	93010	broad.mit.edu	37	2	232262571	232262571	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:232262571G>T	ENST00000287590.5	+	2	402	c.141G>T	c.(139-141)aaG>aaT	p.K47N	B3GNT7_ENST00000479618.1_3'UTR	NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	47					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		AGCCACAGAAGGCCCAGAAGC	0.642000													24	10					3.28513e-13	5.00616e-13	0.667858	1	0
SEMA6D	80031	broad.mit.edu	37	15	48053394	48053394	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:48053394T>G	ENST00000316364.5	+	5	761	c.322T>G	c.(322-324)Tgt>Ggt	p.C108G	SEMA6D_ENST00000537942.1_Missense_Mutation_p.C108G|SEMA6D_ENST00000389428.3_Missense_Mutation_p.C108G|SEMA6D_ENST00000558014.1_Missense_Mutation_p.C108G|SEMA6D_ENST00000389425.3_Missense_Mutation_p.C108G|SEMA6D_ENST00000355997.3_Missense_Mutation_p.C108G|SEMA6D_ENST00000389432.2_Missense_Mutation_p.C108G|SEMA6D_ENST00000558816.1_Missense_Mutation_p.C108G|SEMA6D_ENST00000358066.4_Missense_Mutation_p.C108G|SEMA6D_ENST00000536845.2_Missense_Mutation_p.C108G|SEMA6D_ENST00000354744.4_Missense_Mutation_p.C108G|SEMA6D_ENST00000389433.2_Missense_Mutation_p.C108G	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	108	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCGAGAAAACTGTGCTATGAA	0.408000													7	34					0	0	0.361761	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124783285	124783285	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:124783285C>A	ENST00000431078.1	+	1	422	c.58C>A	c.(58-60)Cat>Aat	p.H20N	CNTNAP5_ENST00000423939.2_3'UTR	NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	20					cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGCTTGTGGCATTTAGGATT	0.502000													12	81					0.00316338	0.00335975	0.479597	1	0
ANKRD36	375248	broad.mit.edu	37	2	97845666	97845666	+	Silent	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:97845666G>A	ENST00000420699.2	+	24	1975	c.1731G>A	c.(1729-1731)ggG>ggA	p.G577G	ANKRD36_ENST00000461153.2_Silent_p.G577G	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	577										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CAATATCTGGGACAGGTAATT	0.378000													8	122					0	0	0.335167	0	0
SNHG14	104472715	broad.mit.edu	37	15	25324282	25324282	+	RNA	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:25324282G>T	ENST00000549804.2	+	0	1377				SNORD116-13_ENST00000384408.1_RNA																							TATCATCTTAGTTGAACTGAG	0.438000													36	27					8.69298e-16	1.41524e-15	0.827153	1	0
ZFC3H1	196441	broad.mit.edu	37	12	72024498	72024498	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:72024498C>G	ENST00000378743.3	-	18	3964	c.3606G>C	c.(3604-3606)caG>caC	p.Q1202H		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1202					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CTTGTATATGCTGCCTAAGAT	0.313000													4	23					0	0	0.150653	0	0
LSAMP	4045	broad.mit.edu	37	3	115529219	115529219	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:115529219G>T	ENST00000490035.1	-	7	1461	c.962C>A	c.(961-963)gCc>gAc	p.A321D	LSAMP_ENST00000539563.1_Missense_Mutation_p.A341D	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	321					cell adhesion|nervous system development	anchored to membrane|plasma membrane		p.A321V(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CAGTGGTACGGCCAGACTGAT	0.423000													13	8					1.15088e-07	1.44013e-07	0.500413	1	0
IGHV4-34	28395	broad.mit.edu	37	14	106829721	106829721	+	RNA	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:106829721C>T	ENST00000390616.2	-	0	272																											GTTGGTGCTTCCACTATGATT	0.562000													21	162					0	0	0.624587	0	0
MS4A6E	245802	broad.mit.edu	37	11	60102502	60102502	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:60102502T>A	ENST00000300182.4	+	1	199	c.134T>A	c.(133-135)gTc>gAc	p.V45D		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	45						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						CAGGCAAAAGTCAAAGTTATT	0.458000													20	33					0	0	0.624587	0	0
PKHD1	5314	broad.mit.edu	37	6	51824798	51824798	+	Silent	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:51824798C>A	ENST00000371117.3	-	36	6053	c.5778G>T	c.(5776-5778)cgG>cgT	p.R1926R	PKHD1_ENST00000340994.4_Silent_p.R1926R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1926					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TGGACCATCTCCGGCAGAACT	0.522000											OREG0017492	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	94					6.31663e-08	8.01611e-08	0.479597	1	0
THSD1	55901	broad.mit.edu	37	13	52971655	52971655	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:52971655C>G	ENST00000349258.4	-	3	1277	c.733G>C	c.(733-735)Gtg>Ctg	p.V245L	THSD1_ENST00000544466.1_Intron|THSD1_ENST00000258613.4_Missense_Mutation_p.V245L	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	245						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGCACCATCACCAGTTTGTAT	0.547000													10	19					0	0	0.387290	0	0
ATP2A1	487	broad.mit.edu	37	16	28911984	28911984	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:28911984A>T	ENST00000395503.4	+	15	2031	c.1847A>T	c.(1846-1848)gAc>gTc	p.D616V	ATP2A1_ENST00000536376.1_Missense_Mutation_p.D491V|ATP2A1_ENST00000357084.3_Missense_Mutation_p.D616V	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	616					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						CTGTGCCGTGACGCCGGGATC	0.617000													32	69					0	0	0.819951	0	0
TCP11L2	255394	broad.mit.edu	37	12	106708156	106708156	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:106708156G>T	ENST00000546625.1	+	3	337	c.178G>T	c.(178-180)Gta>Tta	p.V60L	TCP11L2_ENST00000547153.1_Missense_Mutation_p.V60L|TCP11L2_ENST00000299045.3_Missense_Mutation_p.V60L			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	60										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						TCCAAGGGTTGTAACATTTGA	0.398000													22	61					3.6726e-16	6.02076e-16	0.667858	1	0
TMEM159	57146	broad.mit.edu	37	16	21181907	21181907	+	Silent	SNP	G	G	T	rs74662584		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:21181907G>T	ENST00000233047.4	+	3	714	c.246G>T	c.(244-246)ctG>ctT	p.L82L	TMEM159_ENST00000572599.1_Silent_p.L82L|TMEM159_ENST00000574092.1_3'UTR|TMEM159_ENST00000261388.3_Silent_p.L82L|TMEM159_ENST00000451578.2_Silent_p.L106L|TMEM159_ENST00000572258.1_Silent_p.L82L			Q96B96	TM159_HUMAN	transmembrane protein 159	82						integral to membrane				large_intestine(3)|lung(2)|ovary(1)	6				GBM - Glioblastoma multiforme(48;0.0972)		CTGCTCTGCTGGGGGTCATAA	0.453000													66	60					7.2426e-40	1.55423e-39	0.870114	1	0
GPALPP1	55425	broad.mit.edu	37	13	45601953	45601953	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr13:45601953C>T	ENST00000361121.2	+	8	873	c.838C>T	c.(838-840)Cat>Tat	p.H280Y	KIAA1704_ENST00000379151.4_Missense_Mutation_p.H280Y|RP11-321C24.1_ENST00000437748.2_lincRNA|KIAA1704_ENST00000357537.3_Missense_Mutation_p.H110Y			Q8IXQ4	K1704_HUMAN		280				H -> Q (in Ref. 7; AAH17776).						breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|prostate(2)|skin(1)	12		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		TATGGACATACATCATAAAAA	0.343000													6	11					0	0	0.278610	0	0
OR10P1	121130	broad.mit.edu	37	12	56030911	56030911	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:56030911C>G	ENST00000309675.2	+	1	268	c.236C>G	c.(235-237)cCc>cGc	p.P79R		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						GACATCGTGCCCAGGACCCTG	0.602000													21	58					0	0	0.681144	0	0
LYZL2	119180	broad.mit.edu	37	10	30915081	30915081	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr10:30915081C>A	ENST00000375318.2	-	3	445	c.389G>T	c.(388-390)aGa>aTa	p.R130I		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	84					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				CTTTCCGCGTCTGCACCACGC	0.577000													19	100					6.44725e-10	8.87617e-10	0.624587	1	0
WDR78	79819	broad.mit.edu	37	1	67292623	67292623	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:67292623G>C	ENST00000371026.3	-	15	2274	c.2219C>G	c.(2218-2220)tCt>tGt	p.S740C	WDR78_ENST00000431318.1_Missense_Mutation_p.S453C	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	740										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						AAAACTCAAAGATGGCTTGAC	0.388000													24	104					0	0	0.693898	0	0
COLEC12	81035	broad.mit.edu	37	18	335057	335057	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr18:335057A>G	ENST00000400256.3	-	6	1708	c.1501T>C	c.(1501-1503)Tct>Cct	p.S501P		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	501	Collagen-like 2.				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GAGCCTTTAGATCCTTTGCCG	0.692000													6	32					0	0	0.278610	0	0
TNS3	64759	broad.mit.edu	37	7	47336718	47336718	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:47336718G>A	ENST00000398879.1	-	24	4004	c.3638C>T	c.(3637-3639)gCc>gTc	p.A1213V	TNS3_ENST00000311160.9_Missense_Mutation_p.A1213V|TNS3_ENST00000355730.3_Missense_Mutation_p.A973V			Q68CZ2	TENS3_HUMAN	tensin 3	1213	SH2.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGGGGGCGTGGCCACCTTCAT	0.532000													34	66					0	0	0.834066	0	0
ZNF419	79744	broad.mit.edu	37	19	58004507	58004507	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:58004507G>T	ENST00000424930.2	+	5	814	c.585G>T	c.(583-585)gaG>gaT	p.E195D	ZNF419_ENST00000426954.2_Missense_Mutation_p.E182D|ZNF419_ENST00000415379.2_Missense_Mutation_p.E148D|AC003005.4_ENST00000601674.1_Intron|ZNF419_ENST00000347466.6_Missense_Mutation_p.E162D|ZNF419_ENST00000221735.7_Missense_Mutation_p.E194D|ZNF419_ENST00000442920.2_Missense_Mutation_p.E181D|ZNF419_ENST00000354197.4_Missense_Mutation_p.E182D	NM_001098491.1|NM_024691.3	NP_001091961.1|NP_078967.3	Q96HQ0	ZN419_HUMAN	zinc finger protein 419	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		AAAGTAGGGAGGCCTTTCATG	0.493000													42	10					9.52127e-25	1.83221e-24	0.870114	1	0
GNL2	29889	broad.mit.edu	37	1	38058343	38058343	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:38058343delC	ENST00000373062.3	-	3	312	c.214delG	c.(214-216)cafs	p.A72fs		NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	72					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				TCTACTCTTGCCACTGTGCCA	0.383													59	132	---	---	---	---					
CYP4Z2P	163720	broad.mit.edu	37	1	47310359	47310360	+	RNA	INS	-	-	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:47310359_47310360insT	ENST00000505841.1	-	0	1269					NR_002788.2																						CAAAAACAAAACCCTAGATATT	0.421													3	6	---	---	---	---					
FCRL5	83416	broad.mit.edu	37	1	157514223	157514223	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:157514223delG	ENST00000361835.3	-	5	830	c.673delC	c.(673-675)ggfs	p.R225fs	FCRL5_ENST00000356953.4_Frame_Shift_Del_p.R225fs|FCRL5_ENST00000368190.3_Frame_Shift_Del_p.R225fs|FCRL5_ENST00000368189.3_Frame_Shift_Del_p.R225fs|FCRL5_ENST00000368191.3_Frame_Shift_Del_p.R140fs	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	225	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AAGCGGAACCGGAGCGGGACA	0.557													43	168	---	---	---	---					
SHCBP1L	81626	broad.mit.edu	37	1	182909601	182909602	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr1:182909601_182909602insT	ENST00000367547.3	-	3	868_869	c.632_633insA	c.(631-633)aatfs	p.N211fs	SHCBP1L_ENST00000488956.1_5'UTR|SHCBP1L_ENST00000423786.1_Frame_Shift_Ins_p.N92fs	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	283										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TATTTGCAATGTTGGAAGAAAA	0.386													12	78	---	---	---	---					
IGKV3-7	28915	broad.mit.edu	37	2	89278152	89278152	+	RNA	DEL	A	A	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:89278152delA	ENST00000390247.2	-	0	279																											GCGCCTGGCCAGGTTTCTGCT	0.582													18	102	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91899626	91899626	+	RNA	DEL	A	A	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr2:91899626delA	ENST00000436174.1	-	0	168																											CCAGAGGCTCAAAAAAAAAAA	0.289													4	2	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12203171	12203172	+	RNA	INS	-	-	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:12203171_12203172insA	ENST00000432424.2	+	0	1009							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TCAGAGCGCCCATTTGTGAACT	0.510													6	7	---	---	---	---					
ARIH2	10425	broad.mit.edu	37	3	49006061	49006062	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:49006061_49006062delGC	ENST00000356401.4	+	7	972_973	c.633_634delGC	c.(631-636)aggcfs	p.RR211fs	ARIH2_ENST00000449376.1_Frame_Shift_Del_p.RR211fs|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	211					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		AGAAATACAGGCGCTACCTCTT	0.515													27	134	---	---	---	---					
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	-	A	rs150160917	by1000genomes	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:129268107_129268108insA	ENST00000324382.2	+	3	647_648	c.642_643insA	c.(640-645)gcggaafs	p.E215fs	H1FOO_ENST00000503977.1_Frame_Shift_Ins_p.E76fs	NM_153833.1	NP_722575.1	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	215					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			endometrium(1)|lung(4)|skin(1)	6						CGGGAGAGGCTAGGAAGGTGCC	0.653													3	6	---	---	---	---					
MFSD1	64747	broad.mit.edu	37	3	158531838	158531838	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr3:158531838delG	ENST00000415822.2	+	7	922	c.781delG	c.(781-783)ggfs	p.G261fs	MFSD1_ENST00000392813.4_Frame_Shift_Del_p.G222fs|MFSD1_ENST00000264266.8_Frame_Shift_Del_p.G212fs	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1	212					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CACAACCCTCGGGATCACACT	0.458													42	83	---	---	---	---					
CLOCK	9575	broad.mit.edu	37	4	56336954	56336954	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:56336954delA	ENST00000309964.4	-	7	618	c.368delT	c.(367-369)tafs	p.L123fs	CLOCK_ENST00000513440.1_Frame_Shift_Del_p.L123fs|CLOCK_ENST00000381322.1_Frame_Shift_Del_p.L123fs	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	123	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.L123fs*1(2)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CATGATTGCTAAAAAAAAACC	0.289													17	506	---	---	---	---					
STATH	6779	broad.mit.edu	37	4	70866591	70866591	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:70866591delC	ENST00000246895.4	+	5	225	c.114delC	c.(112-114)ggfs	p.G38fs	STATH_ENST00000381060.2_Frame_Shift_Del_p.G28fs	NM_003154.2	NP_003145.1	P02808	STAT_HUMAN	statherin	38	Hydrophobic; inhibits precipitation of calcium phosphate salts.				biomineral tissue development|negative regulation of bone mineralization|ossification|saliva secretion	extracellular region	extracellular matrix constituent, lubricant activity|hydroxyapatite binding|protein binding|structural constituent of tooth enamel			lung(2)|skin(1)	3						ATGGGTATGGCCCTTATCAGC	0.368													23	103	---	---	---	---					
GLRB	2743	broad.mit.edu	37	4	157999268	157999269	+	Frame_Shift_Ins	INS	-	-	T	rs149863285	byFrequency	TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr4:157999268_157999269insT	ENST00000264428.4	+	2	362_363	c.92_93insT	c.(91-93)aggfs	p.R31fs	GLRB_ENST00000512619.1_Frame_Shift_Ins_p.R31fs|GLRB_ENST00000541722.1_Frame_Shift_Ins_p.R31fs|GLRB_ENST00000509282.1_Frame_Shift_Ins_p.R31fs	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	31					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AAGAAAGGGAAGGGGAAAAAGA	0.332													11	56	---	---	---	---					
CSF1R	1436	broad.mit.edu	37	5	149447806	149447808	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr5:149447806_149447808delAGC	ENST00000286301.3	-	11	1887_1889	c.1596_1598delGCT	c.(1594-1599)ctc>ct	p.LL536del		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	536			L -> V (in dbSNP:rs55942044).		cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	Tagcagcaggagcagcagcagca	0.596													9	282	---	---	---	---					
POLH	5429	broad.mit.edu	37	6	43550832	43550832	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:43550832delC	ENST00000372236.4	+	3	521	c.226delC	c.(226-228)tafs	p.L77fs	POLH_ENST00000372226.1_Frame_Shift_Del_p.L77fs|POLH_ENST00000535400.1_Frame_Shift_Del_p.L15fs	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	77	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TCCAGATCTTCTACTGGCACA	0.393								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				16	31	---	---	---	---					
GFRAL	389400	broad.mit.edu	37	6	55196546	55196546	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:55196546delC	ENST00000340465.2	+	2	142	c.56delC	c.(55-57)tcfs	p.S19fs		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	19						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GAATACACTTCCCAAACCAAT	0.343													40	72	---	---	---	---					
SMAP1	60682	broad.mit.edu	37	6	71567765	71567766	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr6:71567765_71567766insT	ENST00000370455.3	+	10	1350_1351	c.1102_1103insT	c.(1102-1104)gggfs	p.G368fs	SMAP1_ENST00000370452.3_Frame_Shift_Ins_p.G341fs|SMAP1_ENST00000316999.5_Frame_Shift_Ins_p.G341fs|B3GAT2_ENST00000230053.6_3'UTR	NM_001044305.1	NP_001037770.1	Q8IYB5	SMAP1_HUMAN	small ArfGAP 1	368					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						AAGCATGATGGTGGGCATGCCC	0.545													71	132	---	---	---	---					
LANCL2	55915	broad.mit.edu	37	7	55466256	55466257	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:55466256_55466257insT	ENST00000254770.2	+	3	1041_1042	c.463_464insT	c.(463-465)ggcfs	p.G155fs	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	155					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGCTGGCCCCCTGGCTGTTGGA	0.485													17	81	---	---	---	---					
CRCP	27297	broad.mit.edu	37	7	65599298	65599298	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:65599298delG	ENST00000395326.3	+	4	534	c.176delG	c.(175-177)agfs	p.R59fs	CRCP_ENST00000338592.5_Frame_Shift_Del_p.R26fs|CRCP_ENST00000398684.2_Intron|CRCP_ENST00000415001.2_Frame_Shift_Del_p.R26fs|AC068533.7_ENST00000450043.1_Frame_Shift_Del_p.Q241fs|RP5-1132H15.1_ENST00000435524.2_RNA|CRCP_ENST00000431089.2_Frame_Shift_Del_p.R52fs	NM_014478.4	NP_055293.1	O75575	RPC9_HUMAN	CGRP receptor component	59					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding	p.R59K(2)|p.R52K(1)		cervix(1)|kidney(1)|lung(4)	6						ACACCATGCAGGCACCAGAGT	0.358													21	180	---	---	---	---					
TMEM229A	730130	broad.mit.edu	37	7	123672457	123672459	+	In_Frame_Del	DEL	GCT	GCT	-	rs72310362		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:123672457_123672459delGCT	ENST00000455783.1	-	1	1064_1066	c.599_601delAGC	c.(598-603)cgg>c	p.QR200del	RP5-921G16.1_ENST00000484322.1_RNA	NM_001136002.1	NP_001129474.1	B2RXF0	T229A_HUMAN	transmembrane protein 229A	200						host cell nucleus|integral to membrane	sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(3)	6						GCGCCCCTCCgctgctgctgctg	0.754													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149526874	149526874	+	RNA	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr7:149526874delC	ENST00000378016.2	+	0	15142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			cctcctgtgtcccccccacag	0.657													2	4	---	---	---	---					
EXT1	2131	broad.mit.edu	37	8	118819554	118819555	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr8:118819554_118819555delGC	ENST00000378204.2	-	9	2590_2591	c.1784_1785delGC	c.(1783-1785)cfs	p.R595fs		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	595					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			AGAAGTGGCTGCGCGCGGGGTA	0.530			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				56	42	---	---	---	---					
CARS	833	broad.mit.edu	37	11	3063445	3063446	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:3063445_3063446insA	ENST00000380525.4	-	3	384_385	c.315_316insT	c.(313-318)gcggacfs	p.D106fs	CARS_ENST00000401769.3_Frame_Shift_Ins_p.D36fs|CARS_ENST00000278224.9_Frame_Shift_Ins_p.D23fs|CARS_ENST00000397114.3_5'UTR|CARS_ENST00000397111.5_Frame_Shift_Ins_p.D23fs	NM_001014437.2|NM_001194997.1	NP_001014437.1|NP_001181926.1	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	23					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	GGCTGGGTCCCAGCAGGAGGGG	0.624			T	ALK	ALCL								33	140	---	---	---	---					
SBF2	81846	broad.mit.edu	37	11	9989990	9989990	+	Frame_Shift_Del	DEL	G	G	-	rs146366305		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:9989990delG	ENST00000256190.8	-	14	1635	c.1498delC	c.(1498-1500)ggfs	p.R500fs		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	500					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCCTGAACCCGGGCTTCATTA	0.448													61	133	---	---	---	---					
OR8J1	219477	broad.mit.edu	37	11	56128471	56128471	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:56128471delT	ENST00000303039.3	+	1	781	c.749delT	c.(748-750)atfs	p.I250fs		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GCAGTCACAATTTTTTATGGG	0.348													17	149	---	---	---	---					
SLC25A45	283130	broad.mit.edu	37	11	65144126	65144126	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:65144126delC	ENST00000417511.2	-	10	1627	c.493delG	c.(493-495)cafs	p.A165fs	SLC25A45_ENST00000526432.1_Frame_Shift_Del_p.A145fs|SLC25A45_ENST00000527174.1_Frame_Shift_Del_p.A207fs|SLC25A45_ENST00000294187.6_Frame_Shift_Del_p.A165fs|SLC25A45_ENST00000360662.3_Frame_Shift_Del_p.A183fs|SLC25A45_ENST00000398802.1_Frame_Shift_Del_p.A207fs|SLC25A45_ENST00000377152.2_Frame_Shift_Del_p.A103fs|SLC25A45_ENST00000534028.1_Frame_Shift_Del_p.A183fs	NM_001278251.1	NP_001265180.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	207					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						AAGCCCCCTGCCACCAGCACC	0.612													10	47	---	---	---	---					
SLCO2B1	11309	broad.mit.edu	37	11	74914385	74914385	+	Frame_Shift_Del	DEL	C	C	-	rs146349897		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr11:74914385delC	ENST00000289575.5	+	13	2257	c.1862delC	c.(1861-1863)gcfs	p.A621fs	SLCO2B1_ENST00000454962.2_Frame_Shift_Del_p.A394fs|SLCO2B1_ENST00000428359.2_Frame_Shift_Del_p.A599fs|SLCO2B1_ENST00000525650.1_Frame_Shift_Del_p.A477fs|SLCO2B1_ENST00000341411.4_Frame_Shift_Del_p.A394fs|SLCO2B1_ENST00000532236.1_Frame_Shift_Del_p.A505fs	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	621					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CACGGCAGCGCCATCGACACC	0.632													66	83	---	---	---	---					
DRAM1	55332	broad.mit.edu	37	12	102301996	102302002	+	Frame_Shift_Del	DEL	CGCTCTT	CGCTCTT	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:102301996_102302002delCGCTCTT	ENST00000258534.8	+	4	814_820	c.375_381delCGCTCTT	c.(373-381)ggfs	p.GAL125fs	DRAM1_ENST00000544152.1_Intron	NM_018370.2	NP_060840.2	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	125					apoptosis|autophagy	integral to membrane|lysosomal membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12						ATGACGGGGGCGCTCTTTTGGCCTTTG	0.502													18	98	---	---	---	---					
OAS2	4939	broad.mit.edu	37	12	113425160	113425160	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr12:113425160delC	ENST00000449768.2	+	2	622	c.495delC	c.(493-495)tgfs	p.C165fs	OAS2_ENST00000392583.2_Intron|OAS2_ENST00000342315.4_Intron|RP1-71H24.1_ENST00000552784.1_RNA	NM_001032731.1	NP_001027903.1	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	257	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GAAGCGGGTGCCAGACAGCTC	0.498													8	17	---	---	---	---					
G2E3	55632	broad.mit.edu	37	14	31077156	31077156	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:31077156delG	ENST00000206595.6	+	12	1535	c.1381delG	c.(1381-1383)gtfs	p.G461fs	G2E3_ENST00000438909.2_Frame_Shift_Del_p.G415fs|G2E3_ENST00000553504.1_Frame_Shift_Del_p.G491fs	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	461	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGTTCACGGTGGTCCTTCACC	0.353													17	28	---	---	---	---					
FRMD6	122786	broad.mit.edu	37	14	52169245	52169245	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr14:52169245delG	ENST00000395718.2	+	5	571	c.286delG	c.(286-288)ggfs	p.G96fs	FRMD6_ENST00000356218.4_Frame_Shift_Del_p.G96fs|FRMD6_ENST00000554167.1_Frame_Shift_Del_p.G27fs|FRMD6_ENST00000344768.5_Frame_Shift_Del_p.G104fs	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	104	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					CGACCAATTTGGGCCTCCTAT	0.383													63	187	---	---	---	---					
PRTG	283659	broad.mit.edu	37	15	55919219	55919220	+	Frame_Shift_Ins	INS	-	-	T			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:55919219_55919220insT	ENST00000389286.4	-	17	2960_2961	c.2913_2914insA	c.(2911-2916)tagaagfs	p.K972fs		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	972					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GCTTTACTTCGGTATATCAAGA	0.411													42	59	---	---	---	---					
PAQR5	54852	broad.mit.edu	37	15	69696146	69696147	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr15:69696146_69696147insA	ENST00000340965.3	+	9	1646_1647	c.978_979insA	c.(976-981)caaaaafs	p.QK326fs	RP11-253M7.1_ENST00000560539.1_RNA|PAQR5_ENST00000561153.1_Frame_Shift_Ins_p.QK326fs|RP11-253M7.1_ENST00000558617.1_RNA|PAQR5_ENST00000395407.2_Frame_Shift_Ins_p.QK326fs	NM_001104554.1	NP_001098024.1	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	326					cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|skin(1)	11						CAGAATTACATAAAAAAGAAAC	0.426													7	66	---	---	---	---					
ITGAX	3687	broad.mit.edu	37	16	31384650	31384651	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr16:31384650_31384651insA	ENST00000268296.4	+	20	2568_2569	c.2447_2448insA	c.(2446-2448)gacfs	p.D816fs	ITGAX_ENST00000562522.1_Frame_Shift_Ins_p.D816fs	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	816					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GACTCCTACGGAACCACCATCA	0.614													42	101	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578506	7578523	+	In_Frame_Del	DEL	GGCAGGTCTTGGCCAGTT	GGCAGGTCTTGGCCAGTT	-	rs137852794		TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:7578506_7578523delGGCAGGTCTTGGCCAGTT	ENST00000420246.2	-	5	539_556	c.407_424delAACTGGCCAAGACCTGCC	c.(406-426)cct>c	p.QLAKTCP136del	TP53_ENST00000359597.4_In_Frame_Del_p.QLAKTCP136del|TP53_ENST00000269305.4_In_Frame_Del_p.QLAKTCP136del|TP53_ENST00000413465.2_In_Frame_Del_p.QLAKTCP136del|TP53_ENST00000445888.2_In_Frame_Del_p.QLAKTCP136del|TP53_ENST00000455263.2_In_Frame_Del_p.QLAKTCP136del	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	136	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> E (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(79)|p.A138V(20)|p.A138P(16)|p.C141R(13)|p.C141W(13)|p.T140I(12)|p.C141*(11)|p.K139N(9)|p.0?(8)|p.K139fs*31(7)|p.K139K(7)|p.L137L(6)|p.T140T(6)|p.C9Y(5)|p.Q136H(5)|p.C48Y(5)|p.A138fs*32(5)|p.K139E(5)|p.C141S(5)|p.A138_P142delAKTCP(4)|p.Q136Q(4)|p.C141C(4)|p.C141F(4)|p.A138T(4)|p.K139_T140delKT(3)|p.A138fs*11(3)|p.Q136P(3)|p.K139fs*9(3)|p.L137P(3)|p.C135fs*9(3)|p.C141fs*29(3)|p.L137Q(2)|p.P142fs*28(2)|p.Q136R(2)|p.N131fs*27(2)|p.L137M(2)|p.K139Q(2)|p.K139R(2)|p.P142F(2)|p.P142A(2)|p.P142T(2)|p.P142S(2)|p.C141fs*8(2)|p.K139*(2)|p.L137_W146del10(1)|p.L137fs*12(1)|p.T140fs*9(1)|p.C9S(1)|p.C9R(1)|p.C9W(1)|p.K132_A138delKMFCQLA(1)|p.A6_P10delAKTCP(1)|p.A138del(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.T140fs*30(1)|p.K46_T47delKT(1)|p.K46E(1)|p.K139_C141>N(1)|p.P142del(1)|p.P142fs*7(1)|p.F134_T140>S(1)|p.A45_P49delAKTCP(1)|p.Q136L(1)|p.K7fs*31(1)|p.K46fs*31(1)|p.T140N(1)|p.C48S(1)|p.C48R(1)|p.C48W(1)|p.C135_A138delCQLA(1)|p.Y126fs*11(1)|p.L137_A138insX(1)|p.Q136fs*34(1)|p.C141_P142insXX(1)|p.K139fs*29(1)|p.A45P(1)|p.L137V(1)|p.A45V(1)|p.A138fs*31(1)|p.K139fs*4(1)|p.K7_T8delKT(1)|p.C3fs*9(1)|p.A6P(1)|p.C42fs*9(1)|p.A6V(1)|p.C135_T140delCQLAKT(1)|p.K7E(1)|p.K139T(1)|p.P142_Q144delPVQ(1)|p.S127_Q136del10(1)|p.C141fs*34(1)|p.C141fs*30(1)|p.V73fs*9(1)|p.L137fs*33(1)|p.A138_V143delAKTCPV(1)|p.Q136_K139delQLAK(1)|p.C141A(1)|p.C141G(1)|p.A138A(1)|p.T140fs*28(1)|p.A138S(1)|p.C141fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGCACAGGGCAGGTCTTGGCCAGTTGGCAAAACAT	0.569		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	41	---	---	---	---					
OR4D2	124538	broad.mit.edu	37	17	56247174	56247174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr17:56247174delC	ENST00000545221.1	+	1	158	c.158delC	c.(157-159)tcfs	p.S53fs		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						ACCTCTGATTCCCAGCTCCAC	0.488													146	68	---	---	---	---					
GRIN3B	116444	broad.mit.edu	37	19	1005248	1005248	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr19:1005248delC	ENST00000234389.3	+	3	1767	c.1748delC	c.(1747-1749)ggfs	p.A584fs	GRIN3B_ENST00000588335.1_3'UTR	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	584					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity	p.A583V(1)		breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GGCGTCTTTGCGGCCCTGCAC	0.672													12	48	---	---	---	---					
KIAA1755	85449	broad.mit.edu	37	20	36869076	36869076	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:36869076delG	ENST00000279024.4	-	3	1728	c.1457delC	c.(1456-1458)cgfs	p.P486fs		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	486										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GGCTTTCTCCGGGGTCACAGA	0.567													25	57	---	---	---	---					
ZNF334	55713	broad.mit.edu	37	20	45130332	45130335	+	Frame_Shift_Del	DEL	CATT	CATT	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:45130332_45130335delCATT	ENST00000457685.2	-	6	2852_2855	c.1529_1532delAATG	c.(1528-1533)gtfs	p.EC510fs	ZNF334_ENST00000347606.4_Frame_Shift_Del_p.EC548fs|ZNF334_ENST00000593880.1_Frame_Shift_Del_p.EC571fs			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGTTCTCCCACATTCATTGCATTC	0.446													40	187	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	48098610	48098611	+	Frame_Shift_Ins	INS	-	-	C			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chr20:48098610_48098611insC	ENST00000371741.4	-	1	573_574	c.407_408insG	c.(406-408)ctafs	p.L136fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	136					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCTGGTGGTAGCGGGCCTGGCA	0.604													21	126	---	---	---	---					
RBBP7	5931	broad.mit.edu	37	X	16888165	16888165	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:16888165delT	ENST00000380087.2	-	1	372	c.12delA	c.(10-12)aafs	p.K4fs	RBBP7_ENST00000404022.1_Frame_Shift_Del_p.K4fs			Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	4					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			biliary_tract(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	25	Hepatocellular(33;0.0997)					TCTTACTCTCTTTACTCGCCA	0.751													2	4	---	---	---	---					
POU3F4	5456	broad.mit.edu	37	X	82763579	82763579	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:82763579delC	ENST00000373200.2	+	1	311	c.247delC	c.(247-249)ccfs	p.P83fs	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	83					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						GGACGTGAAGCCCGGGCGCGA	0.677													8	7	---	---	---	---					
CHRDL1	91851	broad.mit.edu	37	X	109931877	109931877	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7979-01A-11D-2184-08	TCGA-69-7979-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6400fd9c-3e0d-417e-823a-bf9eb0129717	caa9cc86-69ca-4da0-9356-2b49dfc88dad	g.chrX:109931877delA	ENST00000218054.4	-	9	1126	c.930delT	c.(928-930)tafs	p.Y310fs	CHRDL1_ENST00000394797.4_Frame_Shift_Del_p.Y310fs|CHRDL1_ENST00000372045.1_Frame_Shift_Del_p.Y304fs|CHRDL1_ENST00000372042.1_Frame_Shift_Del_p.Y311fs|CHRDL1_ENST00000482160.1_Frame_Shift_Del_p.Y231fs|CHRDL1_ENST00000444321.2_Frame_Shift_Del_p.Y310fs|CHRDL1_ENST00000434224.1_Frame_Shift_Del_p.Y231fs	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	304	VWFC 3.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TTTTTTGAGGATACTTGCAGG	0.463													21	186	---	---	---	---					
