Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CGNL1	84952	broad.mit.edu	37	15	57809044	57809044	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:57809044G>A	ENST00000281282.5	+	9	2548	c.2470G>A	c.(2470-2472)Gtg>Atg	p.V824M		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	824						myosin complex|tight junction	motor activity	p.V824M(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGAAATGCGCGTGAAGCTTCT	0.522000													9	41					0	0	0.008291	0	0
CAMTA1	23261	broad.mit.edu	37	1	7792506	7792506	+	Splice_Site	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:7792506A>G	ENST00000303635.7	+	12	3121		c.e12-1		CAMTA1_ENST00000439411.2_Splice_Site	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding	p.?(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCTCTGCCCTAGATAACCAGT	0.582000			T	WWTR1	epitheliod hemangioendothelioma								8	23					0	0	0.006214	0	0
PLBD2	196463	broad.mit.edu	37	12	113824835	113824835	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:113824835G>C	ENST00000280800.3	+	10	1411	c.1380G>C	c.(1378-1380)caG>caC	p.Q460H	PLBD2_ENST00000545182.2_Missense_Mutation_p.Q428H	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	460					lipid catabolic process	lysosomal lumen	hydrolase activity	p.Q460H(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CCCGGGCCCAGATCTTCCGGC	0.617000													67	58					0	0	0.014410	0	0
MYH2	4620	broad.mit.edu	37	17	10431163	10431163	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:10431163A>G	ENST00000245503.5	-	28	4157	c.3773T>C	c.(3772-3774)cTa>cCa	p.L1258P	CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.L1258P	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1258					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.L1258P(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTGGTCCTCTAGAGTCCGGCA	0.453000													35	97					0	0	0.007835	0	0
MAOA	4128	broad.mit.edu	37	X	43603416	43603416	+	Nonsense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:43603416A>T	ENST00000338702.3	+	14	1558	c.1435A>T	c.(1435-1437)Aag>Tag	p.K479*	MAOA_ENST00000542639.1_Nonsense_Mutation_p.K346*	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	479					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding	p.K479*(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	ACCTGAATCAAAGGTAAGTTT	0.413000													19	71					0	0	0.008871	0	0
ZNF808	388558	broad.mit.edu	37	19	53057530	53057530	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:53057530C>T	ENST00000359798.4	+	5	1541	c.1361C>T	c.(1360-1362)cCa>cTa	p.P454L		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P454L(1)		endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GGAGAGAAACCATACAAATGT	0.378000													28	29					0	0	0.010818	0	0
MCU	90550	broad.mit.edu	37	10	74631166	74631166	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:74631166A>G	ENST00000536019.1	+	6	987	c.542A>G	c.(541-543)aAg>aGg	p.K181R	MCU_ENST00000373053.3_Missense_Mutation_p.K230R|MCU_ENST00000357157.6_Missense_Mutation_p.K209R|MCU_ENST00000605416.1_3'UTR	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	230					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding	p.K230R(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						AAAGCTGAGAAGAGGACCACT	0.443000													67	231					0	0	0.014410	0	0
LDHD	197257	broad.mit.edu	37	16	75147476	75147476	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:75147476T>C	ENST00000300051.4	-	8	1158	c.1112A>G	c.(1111-1113)cAc>cGc	p.H371R	LDHD_ENST00000450168.2_Missense_Mutation_p.H348R	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	371							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding	p.H371R(1)		endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						CCAGGCATTGTGCCGTGCTGT	0.652000													10	27					0	0	0.003163	0	0
ESPNL	339768	broad.mit.edu	37	2	239039107	239039107	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:239039107C>A	ENST00000343063.3	+	9	2015	c.1752C>A	c.(1750-1752)ccC>ccA	p.P584P	ESPNL_ENST00000409506.1_Silent_p.P216P|ESPNL_ENST00000477241.1_3'UTR|ESPNL_ENST00000409169.1_Silent_p.P540P	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	584								p.P584P(1)		endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		AGGTGGCCCCCGGGGTGCAGC	0.697000													4	5					0.00024832	0.000279497	0.009096	1	0
CACNA1E	777	broad.mit.edu	37	1	181706767	181706767	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:181706767C>A	ENST00000526775.1	+	22	3637	c.3472C>A	c.(3472-3474)Ctg>Atg	p.L1158M	CACNA1E_ENST00000367570.1_Missense_Mutation_p.L1177M|CACNA1E_ENST00000367573.2_Missense_Mutation_p.L1177M|CACNA1E_ENST00000357570.5_Missense_Mutation_p.L1128M|CACNA1E_ENST00000367567.4_Missense_Mutation_p.L784M|CACNA1E_ENST00000358338.5_Missense_Mutation_p.L1109M|CACNA1E_ENST00000360108.3_Missense_Mutation_p.L1158M	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1177					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.L1177K(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GGACCCCGTCCTGACCAACTC	0.612000													77	106					3.89792e-41	7.19076e-41	0.014410	1	0
POLR3B	55703	broad.mit.edu	37	12	106831485	106831485	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:106831485G>A	ENST00000228347.4	+	18	2105	c.1883G>A	c.(1882-1884)aGt>aAt	p.S628N	POLR3B_ENST00000539066.1_Missense_Mutation_p.S570N	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	628					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.S628N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTACATGAGAGTCTGGTTGAA	0.299000													5	45					0	0	0.000602	0	0
ACAT2	39	broad.mit.edu	37	6	160199279	160199279	+	Silent	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:160199279A>G	ENST00000367048.4	+	8	2750	c.990A>G	c.(988-990)gcA>gcG	p.A330A	ACAT2_ENST00000541436.1_Silent_p.A359A|ACAT2_ENST00000472052.1_3'UTR	NM_005891.2	NP_005882.2	Q9BWD1	THIC_HUMAN	acetyl-CoA acetyltransferase 2	330						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding	p.A330A(1)		breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(1)	9		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TCTCTGCTGCAATAGTTAAAG	0.373000													29	32					0	0	0.012213	0	0
OR4K17	390436	broad.mit.edu	37	14	20586106	20586106	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:20586106C>A	ENST00000315543.4	+	1	541	c.541C>A	c.(541-543)Ctc>Atc	p.L181I		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W180_L181>*(1)		kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GACCTCATGGCTCTTGGGTCT	0.453000													17	91					0.00498961	0.00539046	0.004990	1	0
MOGAT1	116255	broad.mit.edu	37	2	223574470	223574470	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:223574470C>G	ENST00000446656.3	+	6	869	c.869C>G	c.(868-870)cCt>cGt	p.P290R		NM_058165.2	NP_477513.2	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	290					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity	p.P290R(1)|p.P289R(1)		breast(1)|cervix(1)|endometrium(1)|lung(5)|urinary_tract(1)	9		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		CGCCCGATCCCTGTTCGTCAG	0.498000													34	174					0	0	0.007835	0	0
IL2RG	3561	broad.mit.edu	37	X	70331295	70331295	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:70331295C>A	ENST00000456850.2	-	1	3	c.4G>T	c.(4-6)Gga>Tga	p.G2*	IL2RG_ENST00000374202.2_Missense_Mutation_p.G32V			P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	0					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding	p.G32V(2)		breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GTCTTCATTCCCATTGGGCGT	0.577000									Severe Combined Immunodeficiency, X-linked				13	61					7.93312e-07	9.51602e-07	0.002450	1	0
C4orf17	84103	broad.mit.edu	37	4	100443752	100443752	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:100443752A>T	ENST00000514652.1	+	3	577	c.223A>T	c.(223-225)Agg>Tgg	p.R75W	C4orf17_ENST00000503257.1_3'UTR|C4orf17_ENST00000326581.4_Missense_Mutation_p.R75W			Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	75								p.R75W(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		AGAGAAGAACAGGATACCATT	0.488000													16	94					0	0	0.007413	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920261	97920261	+	RNA	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:97920261C>T	ENST00000534948.1	+	0	5037							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TTGTTATAACCCTCCTAAAAC	0.289000													10	44					0	0	0.006214	0	0
RIT1	6016	broad.mit.edu	37	1	155874530	155874530	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:155874530C>A	ENST00000368323.3	-	4	433	c.229G>T	c.(229-231)Gct>Tct	p.A77S	RIT1_ENST00000461050.1_5'UTR|RIT1_ENST00000368322.3_Missense_Mutation_p.A94S|RIT1_ENST00000539040.1_Missense_Mutation_p.A41S	NM_006912.5	NP_008843.1	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	77					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity	p.A77S(1)		breast(1)|kidney(1)|large_intestine(3)|lung(12)|skin(1)|urinary_tract(1)	19	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			ACCTGTCCAGCTGTATCCAAA	0.408000													42	43					7.47603e-22	1.22444e-21	0.014410	1	0
PNMA3	29944	broad.mit.edu	37	X	152226624	152226624	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:152226624C>A	ENST00000447306.1	+	2	1548	c.1212C>A	c.(1210-1212)ggC>ggA	p.G404G	PNMA3_ENST00000370265.4_Silent_p.G404G|PNMA3_ENST00000370264.4_Silent_p.G404G	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	404	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding	p.G404G(2)		endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTCGAGGCTCAAGAAAAC	0.592000													24	132					7.33532e-06	8.55787e-06	0.003954	1	0
CCDC178	374864	broad.mit.edu	37	18	30926363	30926363	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:30926363G>A	ENST00000383096.3	-	9	652	c.470C>T	c.(469-471)cCa>cTa	p.P157L	CCDC178_ENST00000583930.1_Missense_Mutation_p.P157L|CCDC178_ENST00000300227.8_Missense_Mutation_p.P157L|CCDC178_ENST00000579947.1_Missense_Mutation_p.P157L|CCDC178_ENST00000406524.2_Missense_Mutation_p.P157L|CCDC178_ENST00000402325.1_Missense_Mutation_p.P157L|CCDC178_ENST00000403303.1_Missense_Mutation_p.P157L|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178									p.P157L(2)									CTTTAACTCTGGACACTTTTC	0.358000													11	46					0	0	0.010729	0	0
ZNF644	84146	broad.mit.edu	37	1	91382454	91382454	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:91382454C>A	ENST00000370440.1	-	6	4102	c.3885G>T	c.(3883-3885)cgG>cgT	p.R1295R	ZNF644_ENST00000361321.5_Silent_p.R73R|ZNF644_ENST00000337393.5_Silent_p.R1295R|ZNF644_ENST00000347275.5_Silent_p.R73R|ZNF644_ENST00000467231.1_5'UTR			Q9H582	ZN644_HUMAN	zinc finger protein 644	1295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R1295R(1)		breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CAGCTCCAGTCCGTGGAAGAT	0.448000													14	58					3.27435e-08	4.01246e-08	0.002450	1	0
PRKCE	5581	broad.mit.edu	37	2	46211804	46211804	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:46211804G>C	ENST00000306156.3	+	6	1135	c.808G>C	c.(808-810)Ggt>Cgt	p.G270R		NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	270					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity	p.G270R(1)	MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CTTGCGGCAGGGTTTGCAGTG	0.562000													35	196					0	0	0.014410	0	0
FSHR	2492	broad.mit.edu	37	2	49216144	49216144	+	Missense_Mutation	SNP	C	C	A	rs142383710	byFrequency	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:49216144C>A	ENST00000406846.2	-	6	615	c.496G>T	c.(496-498)Gtg>Ttg	p.V166L	FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000346173.3_Missense_Mutation_p.V166L|FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000304421.4_Intron	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	166					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding	p.V166L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CTCAGCCCCACGAAAGAATTT	0.338000									Gonadal Dysgenesis, 46 XX				6	28					5.18039e-06	6.08547e-06	0.003080	1	0
USP28	57646	broad.mit.edu	37	11	113700007	113700007	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:113700007C>T	ENST00000003302.4	-	10	1039	c.971G>A	c.(970-972)cGc>cAc	p.R324H	USP28_ENST00000545540.1_Missense_Mutation_p.R199H|USP28_ENST00000537706.1_Missense_Mutation_p.R324H|USP28_ENST00000260188.5_Missense_Mutation_p.R324H|USP28_ENST00000544967.1_Missense_Mutation_p.R32H	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	324					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R324H(1)		breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GTCTAAGTTGCGATAACCGTT	0.458000													4	95					0	0	0.000602	0	0
WISP1	8840	broad.mit.edu	37	8	134239843	134239843	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:134239843C>A	ENST00000250160.6	+	5	1100	c.994C>A	c.(994-996)Cgc>Agc	p.R332S	WISP1_ENST00000519433.1_Missense_Mutation_p.R87S|WISP1_ENST00000220856.6_Missense_Mutation_p.R245S|WISP1_ENST00000517423.1_3'UTR|WISP1_ENST00000377863.2_Missense_Mutation_p.R160S	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	332	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding	p.R332S(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TGGCTTCTCCCGCCAGGTCCT	0.488000													38	69					2.00842e-17	3.13854e-17	0.010771	1	0
MALAT1	378938	broad.mit.edu	37	11	65271640	65271640	+	RNA	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:65271640G>C	ENST00000534336.1	+	0	6408					NR_002819.2																						TCAGGATTTTGAATTGCATAT	0.408000													8	28					0	0	0.004482	0	0
KEAP1	9817	broad.mit.edu	37	19	10597396	10597396	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:10597396C>A	ENST00000171111.5	-	6	2354	c.1807G>T	c.(1807-1809)Ggg>Tgg	p.G603W	KEAP1_ENST00000393623.2_Missense_Mutation_p.G603W	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.G603W(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACGCCCACCCCACTCCGGCCC	0.557000													53	97					4.09106e-26	7.11066e-26	0.014410	1	0
COBL	23242	broad.mit.edu	37	7	51258590	51258590	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:51258590G>A	ENST00000395542.2	-	4	826	c.642C>T	c.(640-642)aaC>aaT	p.N214N	COBL_ENST00000265136.7_Silent_p.N214N|COBL_ENST00000395540.2_Silent_p.N214N|COBL_ENST00000441453.1_Silent_p.N214N			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	214								p.N214N(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TCCCGAGCTCGTTCAGGGACT	0.592000													8	26					0	0	0.004482	0	0
TRIM42	287015	broad.mit.edu	37	3	140406710	140406710	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:140406710G>A	ENST00000286349.3	+	3	1377	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	396						intracellular	zinc ion binding	p.E396K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GATCATCATGGAGCAGATAGA	0.413000													14	122					0	0	0.004007	0	0
MMP2	4313	broad.mit.edu	37	16	55523689	55523689	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:55523689C>A	ENST00000219070.4	+	7	1642	c.1133C>A	c.(1132-1134)aCa>aAa	p.T378K	MMP2_ENST00000570308.1_Missense_Mutation_p.T302K|MMP2_ENST00000543485.1_Missense_Mutation_p.T302K|MMP2_ENST00000437642.2_Missense_Mutation_p.T328K	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	378	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.T378K(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TGTGCGACCACAGCCAACTAC	0.587000													27	64					6.38683e-12	8.74979e-12	0.008361	1	0
FAT3	120114	broad.mit.edu	37	11	92507263	92507263	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:92507263G>T	ENST00000298047.6	+	6	4269	c.4252G>T	c.(4252-4254)Gca>Tca	p.A1418S	FAT3_ENST00000525166.1_Missense_Mutation_p.A1268S|FAT3_ENST00000409404.2_Missense_Mutation_p.A1418S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1418	Cadherin 13.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.A1418S(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATTGTCATCGCAAAACCTTT	0.413000										TCGA Ovarian(4;0.039)			34	66					3.93418e-24	6.61305e-24	0.004289	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68219064	68219064	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:68219064G>A	ENST00000347230.4	-	40	7506	c.7368C>T	c.(7366-7368)ccC>ccT	p.P2456P	ZFYVE26_ENST00000557306.1_Silent_p.P302P	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2456					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding	p.P2456P(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGTGTACCTGGGGCGGAATTC	0.502000													7	22					0	0	0.003080	0	0
KRT2	3849	broad.mit.edu	37	12	53040627	53040627	+	Silent	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:53040627A>G	ENST00000309680.3	-	7	1387	c.1366T>C	c.(1366-1368)Ttg>Ctg	p.L456L		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	456	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton	p.L456L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		AGCCGCGCCAAGTCCTCCTTG	0.617000													18	122					0	0	0.003954	0	0
GPC6	10082	broad.mit.edu	37	13	93879811	93879811	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:93879811C>T	ENST00000377047.4	+	1	717	c.102C>T	c.(100-102)cgC>cgT	p.R34R		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	34						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding	p.R34R(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGAGGTCCGCCAGGCGTACG	0.687000											OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	25					0	0	0.012319	0	0
KLK2	3817	broad.mit.edu	37	19	51379851	51379851	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:51379851C>A	ENST00000325321.3	+	3	555	c.330C>A	c.(328-330)agC>agA	p.S110R	KLK2_ENST00000391810.2_Missense_Mutation_p.S8R|KLK2_ENST00000358049.4_Missense_Mutation_p.S110R			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	110	Peptidase S1.				proteolysis		serine-type endopeptidase activity	p.S110R(2)	KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		AGCATCAAAGCCTTAGACCAG	0.567000			T	ETV4	prostate								16	23					5.3912e-06	6.31859e-06	0.006122	1	0
FANCG	2189	broad.mit.edu	37	9	35075050	35075050	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:35075050T>A	ENST00000378643.3	-	12	2001	c.1510A>T	c.(1510-1512)Aag>Tag	p.K504*	FANCG_ENST00000476212.1_Intron	NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	504					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding	p.K504*(1)		NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCATCTGACTTACATCCCTGC	0.557000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					29	63					0	0	0.010818	0	0
KCNB1	3745	broad.mit.edu	37	20	47991437	47991437	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:47991437G>T	ENST00000371741.4	-	2	826	c.660C>A	c.(658-660)ttC>ttA	p.F220L		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	220					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity	p.F220L(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGGACTGGCCGAACTCATCGA	0.577000													30	53					3.11337e-16	4.74906e-16	0.013726	1	0
GPC2	221914	broad.mit.edu	37	7	99771579	99771579	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:99771579G>A	ENST00000292377.2	-	5	938	c.771C>T	c.(769-771)ctC>ctT	p.L257L	GPC2_ENST00000471050.1_5'UTR	NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	257						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding	p.L257L(1)		NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GACAGCCGATGAGACGCATCA	0.657000													35	160					0	0	0.014410	0	0
CALML3	810	broad.mit.edu	37	10	5567052	5567052	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:5567052G>A	ENST00000315238.1	+	1	129	c.4G>A	c.(4-6)Gcc>Acc	p.A2T	CALML3-AS1_ENST00000545372.1_RNA|RP11-116G8.5_ENST00000442008.2_RNA|CALML3-AS1_ENST00000542093.1_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	2							calcium ion binding	p.A2T(1)		endometrium(3)|lung(2)	5						CCCTGGCATGGCCGACCAGCT	0.667000													3	17					0	0	0.001168	0	0
TIMMDC1	51300	broad.mit.edu	37	3	119217733	119217733	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:119217733G>A	ENST00000494664.1	+	1	355	c.153G>A	c.(151-153)ccG>ccA	p.P51P	TIMMDC1_ENST00000493694.1_Silent_p.P51P	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	51						integral to membrane|mitochondrial inner membrane	protein transporter activity	p.P51P(1)		autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						CCTATTACCCGGAATCTGGAT	0.592000													80	185					0	0	0.014410	0	0
PLOD1	5351	broad.mit.edu	37	1	12009871	12009871	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:12009871G>T	ENST00000196061.4	+	3	237	c.210G>T	c.(208-210)acG>acT	p.T70T	PLOD1_ENST00000485046.1_3'UTR|PLOD1_ENST00000376369.3_Silent_p.T117T	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	70					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity	p.T70T(2)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGAAGGGGACGTCGGCAGGTG	0.557000													33	105					1.05386e-31	1.88294e-31	0.014410	1	0
NCAM1	4684	broad.mit.edu	37	11	113102506	113102506	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:113102506T>A	ENST00000316851.7	+	9	1199	c.1199T>A	c.(1198-1200)cTt>cAt	p.L400H	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.L409H|NCAM1_ENST00000533760.1_Missense_Mutation_p.L282H	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	410	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane		p.L409H(2)|p.L400H(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCCATGTACCTTGAAGTGCAA	0.557000													37	111					0	0	0.011902	0	0
TSNAX-DISC1	100303453	broad.mit.edu	37	1	231672975	231672975	+	Silent	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:231672975T>G	ENST00000602962.1	+	3	296	c.138T>G	c.(136-138)ctT>ctG	p.L46L	TSNAX_ENST00000602825.1_3'UTR|TSNAX_ENST00000366639.4_Silent_p.L46L														p.L46L(1)									AGCAGGAACTTGATGCAAGGC	0.338000													3	127					0	0	0.004672	0	0
MTM1	4534	broad.mit.edu	37	X	149787523	149787523	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:149787523C>A	ENST00000370396.2	+	6	409	c.355C>A	c.(355-357)Ctg>Atg	p.L119M	MTM1_ENST00000306167.7_Intron|MTM1_ENST00000413012.2_Missense_Mutation_p.L82M|MTM1_ENST00000542741.1_Missense_Mutation_p.L24M|MTM1_ENST00000543350.1_Missense_Mutation_p.L4M	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	119					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity	p.L119M(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					CATGAGAAACCTGAGGTTCGC	0.443000													24	87					1.10513e-12	1.55144e-12	0.014323	1	0
MTUS2	23281	broad.mit.edu	37	13	29599385	29599385	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:29599385G>T	ENST00000431530.3	+	1	638	c.580G>T	c.(580-582)Gta>Tta	p.V194L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	184						cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.V194L(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AAGCAGCTCTGTAGCTGCAGT	0.577000													19	43					1.33834e-09	1.70122e-09	0.007413	1	0
FAT2	2196	broad.mit.edu	37	5	150921910	150921910	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:150921910C>A	ENST00000261800.5	-	9	8790	c.8778G>T	c.(8776-8778)gcG>gcT	p.A2926A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2926	Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.A2926A(1)		NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTTTAGAGTCGCCACCAGTT	0.502000													28	209					3.73148e-12	5.16744e-12	0.007291	1	0
TMEM132D	121256	broad.mit.edu	37	12	129822193	129822193	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:129822193C>A	ENST00000422113.2	-	4	1611	c.1285G>T	c.(1285-1287)Gtg>Ttg	p.V429L		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	429						integral to membrane		p.V429L(1)		NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCCAGCGGCACAACTCCAATC	0.617000													125	93					2.31934e-59	4.35729e-59	0.014410	1	0
SCN8A	6334	broad.mit.edu	37	12	52200170	52200170	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:52200170G>A	ENST00000354534.5	+	27	5078	c.4900G>A	c.(4900-4902)Gcc>Acc	p.A1634T	SCN8A_ENST00000545061.1_Missense_Mutation_p.A1593T	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1634					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity	p.A1634T(2)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GATCAAAGGCGCCAAAGGGAT	0.493000													32	238					0	0	0.010818	0	0
FAM83C	128876	broad.mit.edu	37	20	33875579	33875579	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:33875579C>A	ENST00000374408.3	-	4	1099	c.1003G>T	c.(1003-1005)Gtc>Ttc	p.V335F		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	335								p.V335I(1)|p.V335F(1)		central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGGCTTGGGACATCAGGCCTG	0.667000													12	25					6.40141e-05	7.31794e-05	0.010729	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299020	125299020	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:125299020G>T	ENST00000538699.1	-	2	968	c.888C>A	c.(886-888)tcC>tcA	p.S296S	DCAF12L2_ENST00000360028.2_Silent_p.S296S	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	296								p.S296S(3)		NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						ACAGGAGCCTGGATAGTGTGC	0.607000													38	201					1.15505e-17	1.8217e-17	0.009718	1	0
CES5A	221223	broad.mit.edu	37	16	55893498	55893498	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:55893498G>A	ENST00000521992.1	-	9	1249	c.1104C>T	c.(1102-1104)atC>atT	p.I368I	CES5A_ENST00000520435.1_Silent_p.I309I|CES5A_ENST00000319165.9_Silent_p.I339I|CES5A_ENST00000290567.9_Silent_p.I339I|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000518005.1_Silent_p.I233I	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	339						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity	p.I339I(1)|p.I368I(1)		breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TATTGACTCCGATGATGGAAG	0.448000													10	45					0	0	0.013537	0	0
EPSTI1	94240	broad.mit.edu	37	13	43474465	43474465	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:43474465G>T	ENST00000313640.7	-	10	893	c.829C>A	c.(829-831)Cac>Aac	p.H277N	EPSTI1_ENST00000313624.7_Missense_Mutation_p.H266N|EPSTI1_ENST00000398762.3_Missense_Mutation_p.H277N	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	277								p.H277N(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TCAGTCTGGTGGATTTTGGCT	0.353000													18	64					1.2644e-06	1.50977e-06	0.010504	1	0
TMEM204	79652	broad.mit.edu	37	16	1604883	1604883	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:1604883C>A	ENST00000566264.1	+	3	1240	c.537C>A	c.(535-537)gcC>gcA	p.A179A	IFT140_ENST00000439987.2_Intron|TMEM204_ENST00000253934.5_Silent_p.A179A|IFT140_ENST00000426508.2_Intron	NM_024600.5	NP_078876.2	Q9BSN7	TM204_HUMAN	transmembrane protein 204	179					response to stress	adherens junction|integral to membrane		p.A179A(1)		NS(1)|breast(1)|cervix(1)|endometrium(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Hepatocellular(780;0.219)				GCCTTCTGGCCACGCTGGCGG	0.592000													16	37					6.49762e-13	9.22301e-13	0.006122	1	0
SETD2	29072	broad.mit.edu	37	3	47158149	47158149	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:47158149C>A	ENST00000409792.3	-	4	4592	c.4550G>T	c.(4549-4551)gGg>gTg	p.G1517V		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1517	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.G1014V(1)|p.G1517V(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACAATCTTCCCCACATGCTAT	0.338000			"""N, F, S, Mis"""		clear cell renal carcinoma								37	52					4.14481e-20	6.66037e-20	0.006230	1	0
PRIMA1	145270	broad.mit.edu	37	14	94203694	94203694	+	Silent	SNP	G	G	T	rs140716518	byFrequency	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:94203694G>T	ENST00000393140.1	-	4	354	c.252C>A	c.(250-252)ccC>ccA	p.P84P	PRIMA1_ENST00000316227.3_Silent_p.P84P|PRIMA1_ENST00000393143.1_Silent_p.P84P	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	84					neurotransmitter catabolic process	cell junction|integral to membrane|synapse		p.P84P(1)		endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		TTTCCTCAGTGGGGCAAGAGG	0.547000													11	40					4.36969e-10	5.61033e-10	0.001855	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136961	40136961	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:40136961C>A	ENST00000278198.2	-	2	2845	c.882G>T	c.(880-882)gaG>gaT	p.E294D	LRRC4C_ENST00000527150.1_Missense_Mutation_p.E294D|LRRC4C_ENST00000530763.1_Missense_Mutation_p.E294D|LRRC4C_ENST00000528697.1_Missense_Mutation_p.E294D			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	294					regulation of axonogenesis	integral to membrane	protein binding	p.E294D(1)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AATGTATCCGCTCTAGATGAT	0.463000													30	185					2.47316e-13	3.54995e-13	0.003271	1	0
KCNA10	3744	broad.mit.edu	37	1	111060137	111060137	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:111060137C>T	ENST00000369771.2	-	1	1660	c.1273G>A	c.(1273-1275)Ggg>Agg	p.G425R		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	425						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity	p.G425R(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CACATGTCCCCATAGCCTACA	0.567000													11	35					0	0	0.010729	0	0
ANK2	287	broad.mit.edu	37	4	114290956	114290956	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:114290956G>A	ENST00000357077.4	+	43	11658	c.11605G>A	c.(11605-11607)Gaa>Aaa	p.E3869K	ANK2_ENST00000264366.6_Missense_Mutation_p.E3836K|ANK2_ENST00000510275.2_Missense_Mutation_p.E436K|ANK2_ENST00000509550.1_Missense_Mutation_p.E960K|ANK2_ENST00000394537.3_Missense_Mutation_p.E1784K|ANK2_ENST00000506722.1_Missense_Mutation_p.E1775K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3836					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.E3869K(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGCAGCTTTTGAAAAGGTAAG	0.448000													22	42					0	0	0.003954	0	0
NPTX1	4884	broad.mit.edu	37	17	78444626	78444626	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:78444626C>A	ENST00000306773.4	-	5	1443	c.1286G>T	c.(1285-1287)cGc>cTc	p.R429L		NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	429	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding	p.R429L(1)		kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GTTGATCTGGCGACAGGCCTC	0.622000													25	33					1.88708e-17	2.95798e-17	0.008361	1	0
RBM12	10137	broad.mit.edu	37	20	34240590	34240590	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:34240590T>A	ENST00000374114.3	-	3	2918	c.2655A>T	c.(2653-2655)tcA>tcT	p.S885S	CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397445.1_Intron|RBM12_ENST00000374104.3_Silent_p.S885S|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000317677.5_Intron|RBM12_ENST00000359646.1_Silent_p.S885S|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000352393.4_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	885	RRM 3.					nucleus	nucleotide binding|protein binding|RNA binding	p.S885S(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TTAAACACACTGAGCCTGGGA	0.413000													54	97					0	0	0.014410	0	0
NMUR2	56923	broad.mit.edu	37	5	151771875	151771875	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:151771875G>T	ENST00000255262.3	-	4	1290	c.1125C>A	c.(1123-1125)acC>acA	p.T375T		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	375					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity	p.T375T(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CTATATCTTCGGTCAGCTCCA	0.502000													42	72					1.22674e-20	1.99005e-20	0.008740	1	0
ACSM2B	348158	broad.mit.edu	37	16	20551983	20551983	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:20551983G>C	ENST00000329697.6	-	13	1790	c.1622C>G	c.(1621-1623)cCa>cGa	p.P541R	ACSM2B_ENST00000567001.1_Missense_Mutation_p.P541R|ACSM2B_ENST00000565232.1_Missense_Mutation_p.P541R|ACSM2B_ENST00000565322.1_Missense_Mutation_p.P462R	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	541	Coenzyme A binding (By similarity).				fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding	p.P541Q(1)|p.P541R(1)		breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TACCTTTCTTGGGTACTTGTA	0.468000													24	141					0	0	0.004656	0	0
EPHB1	2047	broad.mit.edu	37	3	134911494	134911494	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:134911494G>T	ENST00000398015.3	+	11	2329	c.1959G>T	c.(1957-1959)ctG>ctT	p.L653L	EPHB1_ENST00000493838.1_Silent_p.L214L	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	653	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.L653L(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TCAAGACCCTGAAGGCAGGGT	0.537000													15	29					5.35267e-07	6.45097e-07	0.007413	1	0
NAV3	89795	broad.mit.edu	37	12	78513629	78513629	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:78513629C>A	ENST00000397909.2	+	15	3826	c.3653C>A	c.(3652-3654)cCc>cAc	p.P1218H	NAV3_ENST00000536525.2_Missense_Mutation_p.P1218H|NAV3_ENST00000228327.6_Missense_Mutation_p.P1218H|NAV3_ENST00000266692.7_Missense_Mutation_p.P1218H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1218	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.P1218H(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAGGTTCCCCCAAATCCAGC	0.522000										HNSCC(70;0.22)			51	47					2.76378e-25	4.7552e-25	0.014410	1	0
SLC9A2	6549	broad.mit.edu	37	2	103274403	103274403	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:103274403G>T	ENST00000233969.2	+	2	812	c.670G>T	c.(670-672)Gct>Tct	p.A224S		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	224						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity	p.A224S(1)		breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GGCTGTGCTTGCTGTCTTTGA	0.498000													61	148					9.40535e-28	1.64594e-27	0.014410	1	0
FRMPD1	22844	broad.mit.edu	37	9	37746564	37746564	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:37746564G>T	ENST00000539465.1	+	16	5128	c.4535G>T	c.(4534-4536)cGc>cTc	p.R1512L	FRMPD1_ENST00000377765.3_Missense_Mutation_p.R1512L|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1512						cytoskeleton|cytosol|plasma membrane		p.R1512L(1)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GACTGTAGCCGCTGCTCCGCC	0.617000													37	28					4.92203e-23	8.13966e-23	0.006230	1	0
SOGA2	23255	broad.mit.edu	37	18	8783766	8783766	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:8783766A>G	ENST00000359865.3	+	6	798	c.656A>G	c.(655-657)aAc>aGc	p.N219S	SOGA2_ENST00000400050.3_Missense_Mutation_p.N219S|SOGA2_ENST00000517570.1_Missense_Mutation_p.N219S|SOGA2_ENST00000306329.11_Missense_Mutation_p.N579S|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	570								p.N219S(1)									GAGGAAGCCAACATCTTGGGC	0.682000													7	14					0	0	0.004482	0	0
PHACTR3	116154	broad.mit.edu	37	20	58348440	58348440	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:58348440G>T	ENST00000371015.1	+	6	1325	c.858G>T	c.(856-858)cgG>cgT	p.R286R	PHACTR3_ENST00000395636.2_Silent_p.R245R|PHACTR3_ENST00000395639.4_Silent_p.R175R|PHACTR3_ENST00000359926.3_Silent_p.R283R|PHACTR3_ENST00000355648.4_Silent_p.R245R|PHACTR3_ENST00000541461.1_Silent_p.R245R|PHACTR3_ENST00000361300.4_Silent_p.R175R	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	286						nuclear matrix	actin binding|protein phosphatase inhibitor activity	p.R286R(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CGGTCCACCGGCCTCTTCCCC	0.672000													13	32					2.23348e-06	2.64192e-06	0.004007	1	0
KDR	3791	broad.mit.edu	37	4	55972900	55972900	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:55972900A>G	ENST00000263923.4	-	11	1785	c.1490T>C	c.(1489-1491)aTt>aCt	p.I497T		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	497	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.I497T(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ATTAACTTCAATTTTATTTCC	0.358000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			16	53					0	0	0.003163	0	0
DSC1	1823	broad.mit.edu	37	18	28736036	28736036	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:28736036C>A	ENST00000257197.3	-	4	702	c.441G>T	c.(439-441)tcG>tcT	p.S147S	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.S147S	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	147	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding	p.S147S(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATGGACCCAACGAGTTCTCCA	0.398000													16	44					1.02788e-11	1.38955e-11	0.004990	1	0
NIPBL	25836	broad.mit.edu	37	5	37049380	37049380	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:37049380C>G	ENST00000282516.8	+	40	7430	c.6931C>G	c.(6931-6933)Caa>Gaa	p.Q2311E	NIPBL_ENST00000448238.2_Missense_Mutation_p.Q2311E	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2311					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding	p.Q2311E(2)		autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GACTCTAAATCAAGGTCTTAT	0.383000													5	250					0	0	0.001168	0	0
TRIP12	9320	broad.mit.edu	37	2	230655921	230655921	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:230655921C>T	ENST00000283943.5	-	29	4415	c.4237G>A	c.(4237-4239)Ggt>Agt	p.G1413S	TRIP12_ENST00000389045.3_Missense_Mutation_p.G1143S|TRIP12_ENST00000389044.4_Missense_Mutation_p.G1461S	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1413					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity	p.G1413S(1)		breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTTTTACCACCAACACAATCT	0.363000													20	83					0	0	0.007413	0	0
COL11A1	1301	broad.mit.edu	37	1	103544276	103544276	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:103544276G>T	ENST00000358392.2	-	3	743	c.426C>A	c.(424-426)caC>caA	p.H142Q	COL11A1_ENST00000353414.4_Missense_Mutation_p.H142Q|COL11A1_ENST00000512756.1_Missense_Mutation_p.H142Q|COL11A1_ENST00000370096.3_Missense_Mutation_p.H142Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	142	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.H142Q(2)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTTTTCCAGTGTGGTCTTCAA	0.388000													10	36					2.27111e-07	2.75662e-07	0.013537	1	0
NUP160	23279	broad.mit.edu	37	11	47808067	47808067	+	Silent	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:47808067T>C	ENST00000378460.2	-	32	3832	c.3786A>G	c.(3784-3786)gcA>gcG	p.A1262A	NUP160_ENST00000530326.1_Silent_p.A1148A	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	1262					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding	p.A1262A(1)		NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						CCCAGGCTTCTGCTTGTGCTG	0.463000													36	32					0	0	0.009718	0	0
TUBA4B	80086	broad.mit.edu	37	2	220136344	220136344	+	RNA	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:220136344C>A	ENST00000490341.1	+	0	814					NR_003063.1																						GTCATCTCTGCAGAAAAGGTA	0.562000													10	70					0.000673444	0.000740064	0.008291	1	0
AKAP6	9472	broad.mit.edu	37	14	33293096	33293096	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:33293096G>T	ENST00000280979.4	+	13	6247	c.6077G>T	c.(6076-6078)gGa>gTa	p.G2026V	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2026					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding	p.G2026V(1)		NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAACAAAACGGAACAGAGGAA	0.413000													27	58					8.24728e-16	1.25055e-15	0.004656	1	0
IARS	3376	broad.mit.edu	37	9	95015708	95015708	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:95015708C>T	ENST00000375643.3	-	21	2431	c.2165G>A	c.(2164-2166)cGc>cAc	p.R722H	IARS_ENST00000443024.2_Missense_Mutation_p.R722H|IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.R612H	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	722					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding	p.R722H(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CTTGACCAGGCGAGGCACCAC	0.448000													46	24					0	0	0.014410	0	0
PRDM9	56979	broad.mit.edu	37	5	23521214	23521214	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:23521214C>A	ENST00000296682.3	+	6	616	c.434C>A	c.(433-435)tCa>tAa	p.S145*		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	145					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.S145*(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GCAAGTGGCTCAGAGCAGGCT	0.433000										HNSCC(3;0.000094)			18	57					2.37509e-13	3.41879e-13	0.010504	1	0
C20orf112	140688	broad.mit.edu	37	20	31062425	31062425	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:31062425T>A	ENST00000359676.5	-	2	230	c.88A>T	c.(88-90)Aac>Tac	p.N30Y	C20orf112_ENST00000375677.1_Missense_Mutation_p.N52Y|C20orf112_ENST00000475781.1_5'UTR|C20orf112_ENST00000326071.4_Missense_Mutation_p.N30Y|C20orf112_ENST00000375678.3_Missense_Mutation_p.N139Y	NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	30								p.N30Y(1)		endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						CTGTGGAGGTTCTGCGGGCTC	0.637000													9	38					0	0	0.010729	0	0
SPATA31A3	727830	broad.mit.edu	37	9	40702812	40702812	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:40702812C>A	ENST00000356699.5	+	4	498	c.469C>A	c.(469-471)Cct>Act	p.P157T	SPATA31A3_ENST00000463536.1_3'UTR	NM_001083124.1	NP_001076593.1			SPATA31 subfamily A, member 3									p.P157T(2)									TTCCCCGGATCCTCAAGCCAA	0.587000													151	289					9.53643e-70	1.81157e-69	0.014410	1	0
SP6	80320	broad.mit.edu	37	17	45924888	45924888	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:45924888C>T	ENST00000536300.1	-	2	1239	c.908G>A	c.(907-909)cGc>cAc	p.R303H	SP6_ENST00000342234.2_Missense_Mutation_p.R303H	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R303H(1)		large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						CTGGAGGTGGCGCTGCAGCTC	0.652000													19	44					0	0	0.003330	0	0
ABCG2	9429	broad.mit.edu	37	4	89022469	89022469	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:89022469G>T	ENST00000237612.3	-	11	1825	c.1280C>A	c.(1279-1281)gCt>gAt	p.A427D	ABCG2_ENST00000515655.1_Missense_Mutation_p.A427D	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	427	ABC transmembrane type-2.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity	p.A427D(2)		breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGAACCCCAGCTCTGCCATG	0.448000													5	30					0.000602214	0.00066753	0.000602	1	0
MYT1L	23040	broad.mit.edu	37	2	1926808	1926808	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:1926808G>T	ENST00000399161.2	-	10	1480	c.733C>A	c.(733-735)Cgg>Agg	p.R245R	MYT1L_ENST00000428368.2_Silent_p.R245R	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	245					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R245R(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCACTTTTCCGACCCAGGTTT	0.468000													58	110					5.47352e-35	9.91833e-35	0.014410	1	0
GABRG2	2566	broad.mit.edu	37	5	161576210	161576210	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:161576210C>A	ENST00000356592.3	+	8	1479	c.1019C>A	c.(1018-1020)tCt>tAt	p.S340Y	GABRG2_ENST00000393933.4_Missense_Mutation_p.S245Y|GABRG2_ENST00000414552.2_Missense_Mutation_p.S380Y|GABRG2_ENST00000361925.4_Missense_Mutation_p.S340Y	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	340					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding	p.S340Y(1)		NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTCTTTGTATCTGTTTGTTTC	0.468000													23	59					3.83957e-06	4.53122e-06	0.002780	1	0
TARBP1	6894	broad.mit.edu	37	1	234599596	234599596	+	Silent	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:234599596T>C	ENST00000040877.1	-	6	1385	c.1386A>G	c.(1384-1386)ccA>ccG	p.P462P		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	462					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity	p.P462P(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TTATTTCTTCTGGAAGAAGAG	0.353000													5	10					0	0	0.000602	0	0
PUM1	9698	broad.mit.edu	37	1	31478858	31478858	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:31478858T>C	ENST00000373747.3	-	5	661	c.562A>G	c.(562-564)Atc>Gtc	p.I188V	PUM1_ENST00000373741.4_Missense_Mutation_p.I224V|PUM1_ENST00000440538.2_Missense_Mutation_p.I188V|PUM1_ENST00000426105.2_Missense_Mutation_p.I188V|PUM1_ENST00000424085.2_Intron|PUM1_ENST00000423018.2_Intron|PUM1_ENST00000373742.2_Intron|PUM1_ENST00000257075.5_Missense_Mutation_p.I188V	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	188					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding	p.I188V(1)		breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGCACCATGATTGGCTGGGAA	0.458000													27	24					0	0	0.007291	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420277	56420277	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:56420277G>T	ENST00000407595.2	+	2	1444	c.942G>T	c.(940-942)ccG>ccT	p.P314P	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	314	His-rich.							p.P314P(1)		breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTGGGAGCCCGGAACACTTCC	0.642000													26	76					3.73808e-20	6.02574e-20	0.005443	1	0
KIAA1407	57577	broad.mit.edu	37	3	113723453	113723453	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:113723453A>G	ENST00000545063.1	-	11	2156	c.1502T>C	c.(1501-1503)gTt>gCt	p.V501A	KIAA1407_ENST00000295878.3_Intron			Q8NCU4	K1407_HUMAN	KIAA1407	0										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						GAAGATAACAACCACCAAGGC	0.463000													50	118					0	0	0.014410	0	0
DDHD2	23259	broad.mit.edu	37	8	38099825	38099825	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:38099825A>G	ENST00000397166.2	+	7	1295	c.770A>G	c.(769-771)cAa>cGa	p.Q257R	DDHD2_ENST00000528888.1_3'UTR|DDHD2_ENST00000520272.2_Missense_Mutation_p.Q257R	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	257					lipid catabolic process	centrosome	hydrolase activity|metal ion binding	p.Q257R(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AAGAAAGCCCAAGAAAATCAG	0.373000													10	56					0	0	0.008291	0	0
OR2G2	81470	broad.mit.edu	37	1	247752058	247752058	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:247752058C>A	ENST00000320065.1	+	1	397	c.397C>A	c.(397-399)Ctc>Atc	p.L133I	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L133I(1)		endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTGCCGTCCTCTCCATTACAC	0.547000													93	157					9.11594e-60	1.71891e-59	0.014410	1	0
METTL20	254013	broad.mit.edu	37	12	31814989	31814989	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:31814989T>G	ENST00000357721.3	+	2	317	c.102T>G	c.(100-102)tgT>tgG	p.C34W	METTL20_ENST00000395763.3_Missense_Mutation_p.C34W|METTL20_ENST00000538463.1_Missense_Mutation_p.C34W|METTL20_ENST00000412352.2_Missense_Mutation_p.C34W|METTL20_ENST00000538391.1_Missense_Mutation_p.C34W	NM_001135863.1	NP_001129335.1	Q8IXQ9	MET20_HUMAN	methyltransferase like 20	34						cytoplasm	protein methyltransferase activity	p.C34W(1)		lung(2)|stomach(1)	3						GTGGCCAGTGTCCCTGGAGAG	0.537000													109	79					0	0	0.014410	0	0
RGS12	6002	broad.mit.edu	37	4	3427249	3427249	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:3427249G>T	ENST00000336727.3	+	14	4197	c.3293G>T	c.(3292-3294)cGg>cTg	p.R1098L	RGS12_ENST00000538395.1_Missense_Mutation_p.R440L|RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000382788.3_Missense_Mutation_p.R1098L|RGS12_ENST00000344733.5_Missense_Mutation_p.R1098L|RGS12_ENST00000338806.4_Missense_Mutation_p.R450L|RGS12_ENST00000306648.7_Missense_Mutation_p.R496L	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1098	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity	p.R1098L(1)		autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GACGGACAGCGGGTTGTCTTG	0.592000													73	170					3.20846e-33	5.77298e-33	0.014410	1	0
FAM86HP	729375	broad.mit.edu	37	3	129821757	129821757	+	RNA	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:129821757C>A	ENST00000500074.2	-	0	389																		p.L218L(1)									TACAGCACGTCTACGGTGAAA	0.587000													13	32					0.000566183	0.000633084	0.004990	1	0
BOD1L1	259282	broad.mit.edu	37	4	13605199	13605199	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:13605199C>G	ENST00000040738.5	-	10	3460	c.3325G>C	c.(3325-3327)Ggt>Cgt	p.G1109R		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1109							DNA binding	p.G1109R(1)									GTCATATCACCACTCTTTTTT	0.428000													15	96					0	0	0.003163	0	0
CACNA1E	777	broad.mit.edu	37	1	181765861	181765861	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:181765861G>A	ENST00000526775.1	+	45	6245	c.6080G>A	c.(6079-6081)cGa>cAa	p.R2027Q	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R2046Q|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R2089Q|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R2040Q|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1653Q|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1978Q|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R2070Q	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2089					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.R2089Q(1)|p.R2046Q(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCAAAAGAGCGAAAGCATCTT	0.572000													25	16					0	0	0.006320	0	0
PKP1	5317	broad.mit.edu	37	1	201293685	201293685	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:201293685C>G	ENST00000263946.3	+	11	2124	c.1873C>G	c.(1873-1875)Cac>Gac	p.H625D	PKP1_ENST00000367324.3_Missense_Mutation_p.H604D|PKP1_ENST00000352845.3_Missense_Mutation_p.H625D	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	625					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis	p.H625D(1)|p.H604D(1)		NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CATGTCCCGCCACCCTCTGCT	0.582000													17	29					0	0	0.012319	0	0
PCDH11X	27328	broad.mit.edu	37	X	91137922	91137922	+	Nonsense_Mutation	SNP	C	C	A	rs2525214		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:91137922C>A	ENST00000395337.2	+	6	3683	c.3050C>A	c.(3049-3051)tCa>tAa	p.S1017*	PCDH11X_ENST00000373094.1_Intron|PCDH11X_ENST00000361655.2_Intron|PCDH11X_ENST00000298274.8_Intron|PCDH11X_ENST00000373088.1_Intron|PCDH11X_ENST00000406881.1_Intron|PCDH11X_ENST00000504220.1_Intron|PCDH11X_ENST00000373097.1_Intron	NM_032967.2	NP_116749.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.S1017*(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TCCAGGACATCAACTATTGAA	0.338000													23	43					1.50039e-11	2.01763e-11	0.012319	1	0
XRCC6	2547	broad.mit.edu	37	22	42032775	42032775	+	Splice_Site	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr22:42032775G>T	ENST00000359308.4	+	4	1244		c.e4+1		XRCC6_ENST00000428575.2_Splice_Site|XRCC6_ENST00000360079.3_Splice_Site|XRCC6_ENST00000402580.3_Splice_Site|XRCC6_ENST00000405878.1_Splice_Site|XRCC6_ENST00000405506.1_Splice_Site			P12956	XRCC6_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 6						DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding	p.?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	31						CGAGATACAGGTGGGCATATT	0.463000								Non-homologous end-joining					17	70					3.51602e-12	4.88229e-12	0.008871	1	0
ANO4	121601	broad.mit.edu	37	12	101477524	101477524	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:101477524G>T	ENST00000392979.3	+	15	1720	c.1359G>T	c.(1357-1359)aaG>aaT	p.K453N	ANO4_ENST00000550015.1_Intron|ANO4_ENST00000299222.9_Intron|ANO4_ENST00000392977.3_Missense_Mutation_p.K488N	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	488						chloride channel complex	chloride channel activity	p.K453N(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTTCTGGAAAGCCAGAACCTT	0.348000										HNSCC(74;0.22)			81	48					9.34078e-37	1.71696e-36	0.014410	1	0
CCNB3	85417	broad.mit.edu	37	X	50094666	50094666	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:50094666G>A	ENST00000376042.1	+	13	4450	c.4152G>A	c.(4150-4152)ttG>ttA	p.L1384L	CCNB3_ENST00000376038.1_Silent_p.L280L|CCNB3_ENST00000276014.7_Silent_p.L1384L|CCNB3_ENST00000348603.2_Silent_p.L280L			Q8WWL7	CCNB3_HUMAN	cyclin B3	1384					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding	p.L1384L(2)		breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					AGGAGATTTTGAACTGTGATT	0.468000													15	40					0	0	0.006122	0	0
DDO	8528	broad.mit.edu	37	6	110714065	110714065	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:110714065C>A	ENST00000368924.3	-	5	1038	c.1023G>T	c.(1021-1023)gtG>gtT	p.V341V	DDO_ENST00000368925.1_Silent_p.V313V|DDO_ENST00000368923.3_Silent_p.V282V	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	313					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity	p.V341V(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		TGCCCCAGTGCACTGAGATGC	0.602000													24	37					1.77063e-15	2.66116e-15	0.005443	1	0
KDR	3791	broad.mit.edu	37	4	55981184	55981184	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:55981184G>T	ENST00000263923.4	-	5	810	c.515C>A	c.(514-516)cCt>cAt	p.P172H		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	172	Ig-like C2-type 2.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.P172N(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTTACCATCAGGAACAAATCT	0.378000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			9	28					0.000673444	0.000740064	0.008291	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420473	105420473	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:105420473T>A	ENST00000333244.5	-	7	1434	c.1315A>T	c.(1315-1317)Agg>Tgg	p.R439W		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	439						nucleus		p.R439W(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCTGGGCCCTGGGCTTCCTC	0.642000													33	58					0	0	0.003755	0	0
ANO3	63982	broad.mit.edu	37	11	26463539	26463539	+	Missense_Mutation	SNP	G	G	T	rs150999282		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:26463539G>T	ENST00000256737.3	+	2	973	c.121G>T	c.(121-123)Gcc>Tcc	p.A41S	ANO3_ENST00000531646.1_Missense_Mutation_p.A41S|ANO3_ENST00000537978.1_Missense_Mutation_p.A25S|ANO3_ENST00000525139.1_Missense_Mutation_p.A25S	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	41						chloride channel complex	chloride channel activity	p.A41S(2)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						GCCTTGCCTCGCCCAGAGCTA	0.443000													97	110					2.56585e-57	4.80274e-57	0.014410	1	0
GRM5	2915	broad.mit.edu	37	11	88583213	88583213	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:88583213C>T	ENST00000418177.2	-	3	1139	c.772G>A	c.(772-774)Gat>Aat	p.D258N	GRM5_ENST00000455756.2_Missense_Mutation_p.D258N|GRM5_ENST00000305432.5_Missense_Mutation_p.D258N|GRM5_ENST00000305447.4_Missense_Mutation_p.D258N|GRM5_ENST00000393297.1_Missense_Mutation_p.D258N			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	258					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.D258N(2)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGCAGCTTATCAAAGCTCTGC	0.522000													25	37					0	0	0.013726	0	0
BMPER	168667	broad.mit.edu	37	7	33976923	33976923	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:33976923G>T	ENST00000297161.2	+	4	616	c.242G>T	c.(241-243)aGa>aTa	p.R81I	BMPER_ENST00000426693.1_Missense_Mutation_p.R81I	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	81	VWFC 1.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space		p.R81I(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ACATGTAAGAGAGAGAAGTGC	0.478000													5	110					0.00116845	0.00127308	0.001168	1	0
POTEF	728378	broad.mit.edu	37	2	130832264	130832264	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:130832264C>T	ENST00000357462.5	-	15	2874	c.2781G>A	c.(2779-2781)atG>atA	p.M927I	POTEF_ENST00000409914.2_Missense_Mutation_p.M927I			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	927	Actin-like.					cell cortex	ATP binding	p.M927I(1)		breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CCACCGTGGCCATCTCCTGCT	0.617000													9	58					0	0	0.008291	0	0
OR51G2	81282	broad.mit.edu	37	11	4936463	4936463	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:4936463G>C	ENST00000322013.3	-	1	459	c.431C>G	c.(430-432)aCa>aGa	p.T144R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T144R(1)		autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCAATGACTGTGTTGGTGAG	0.493000													16	17					0	0	0.003330	0	0
TRMT13	54482	broad.mit.edu	37	1	100598771	100598771	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:100598771A>T	ENST00000370141.2	+	1	53	c.47A>T	c.(46-48)gAg>gTg	p.E16V	TRMT13_ENST00000370139.1_5'UTR|TRMT13_ENST00000370143.1_Missense_Mutation_p.E16V	NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)									p.E16V(1)									TTTCCAGCTGAGGGTAGATGC	0.567000													14	53					0	0	0.008871	0	0
PABPC3	5042	broad.mit.edu	37	13	25670983	25670983	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:25670983C>A	ENST00000281589.3	+	1	684	c.647C>A	c.(646-648)cCc>cAc	p.P216H		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	216	RRM 3.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding	p.P216H(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAGTTCGGGCCCGCCTTAAGT	0.428000													37	92					1.31962e-36	2.41693e-36	0.008740	1	0
DOCK9	23348	broad.mit.edu	37	13	99481647	99481647	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:99481647T>A	ENST00000376460.1	-	43	4890	c.4810A>T	c.(4810-4812)Aaa>Taa	p.K1604*	DOCK9_ENST00000339416.2_Nonsense_Mutation_p.K1605*|DOCK9_ENST00000448493.2_3'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1605	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity	p.K1605*(1)|p.K1604*(1)		breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCATAGGATTTGGCCAGGCTG	0.567000													10	12					0	0	0.008291	0	0
CYLC2	1539	broad.mit.edu	37	9	105767379	105767379	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:105767379G>T	ENST00000374798.3	+	5	536	c.466G>T	c.(466-468)Gat>Tat	p.D156Y	CYLC2_ENST00000487798.1_Missense_Mutation_p.D156Y	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	156	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton	p.D156Y(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				agaaaagctagatgcaaagaa	0.353000													20	9					5.35267e-07	6.45097e-07	0.007413	1	0
PLA2G16	11145	broad.mit.edu	37	11	63342429	63342429	+	Silent	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:63342429T>C	ENST00000323646.5	-	4	831	c.477A>G	c.(475-477)cgA>cgG	p.R159R	PLA2G16_ENST00000415826.1_Silent_p.R159R|PLA2G16_ENST00000394613.3_5'UTR	NM_007069.3	NP_009000.2	P53816	PAG16_HUMAN	phospholipase A2, group XVI	159					lipid catabolic process	integral to membrane|perinuclear region of cytoplasm	hydrolase activity|protein binding	p.R159R(1)		kidney(2)|lung(1)|ovary(1)|skin(1)	5						ATTGCTTTTGTCGCTTGTTTC	0.453000													52	82					0	0	0.014410	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655792	40655792	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:40655792C>A	ENST00000406785.1	-	2	1818	c.1629G>T	c.(1627-1629)gaG>gaT	p.E543D	SLC8A1_ENST00000542756.1_Missense_Mutation_p.E543D|SLC8A1_ENST00000542024.1_Missense_Mutation_p.E543D|SLC8A1_ENST00000408028.2_Missense_Mutation_p.E543D|SLC8A1_ENST00000406391.2_Missense_Mutation_p.E543D|SLC8A1_ENST00000405901.3_Missense_Mutation_p.E543D|SLC8A1_ENST00000405269.1_Missense_Mutation_p.E543D|SLC8A1_ENST00000403092.1_Missense_Mutation_p.E543D|SLC8A1_ENST00000402441.1_Missense_Mutation_p.E543D|SLC8A1_ENST00000332839.4_Missense_Mutation_p.E543D			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	543	Calx-beta 2.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.E543D(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCACAGGTTCCTCAAAAGTAA	0.438000													21	95					2.89027e-11	3.85621e-11	0.014323	1	0
STARD13	90627	broad.mit.edu	37	13	33741717	33741717	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:33741717C>G	ENST00000336934.5	-	2	328	c.212G>C	c.(211-213)gGg>gCg	p.G71A	STARD13_ENST00000487412.1_5'UTR|STARD13_ENST00000399365.3_5'UTR|STARD13_ENST00000255486.4_Missense_Mutation_p.G63A	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	71	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding	p.G71A(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TTGCGGGAACCCGGCAGCACG	0.483000													15	38					0	0	0.006122	0	0
COL5A2	1290	broad.mit.edu	37	2	189923246	189923246	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:189923246C>A	ENST00000374866.3	-	33	2412	c.2138G>T	c.(2137-2139)cGa>cTa	p.R713L		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	713					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.R713L(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGGATTTCCTCGTTCTCCCTA	0.438000													9	34					6.40141e-05	7.31794e-05	0.010729	1	0
ZW10	9183	broad.mit.edu	37	11	113614613	113614613	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:113614613C>A	ENST00000200135.3	-	10	1566	c.1422G>T	c.(1420-1422)ttG>ttT	p.L474F		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	474					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding	p.L474F(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		GGCATGTGGGCAAGGAAAAGG	0.403000													64	136					1.02016e-41	1.88877e-41	0.014410	1	0
MKL2	57496	broad.mit.edu	37	16	14345836	14345836	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:14345836G>T	ENST00000571589.1	+	14	2693	c.2521G>T	c.(2521-2523)Gct>Tct	p.A841S	MKL2_ENST00000574045.1_Missense_Mutation_p.A791S|MKL2_ENST00000318282.5_Missense_Mutation_p.A791S|MKL2_ENST00000341243.5_Missense_Mutation_p.A830S	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	830					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity	p.A791S(1)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ATCCAGAAATGCTCCGCTTCC	0.488000													62	94					1.64573e-32	2.95077e-32	0.014410	1	0
ZNF300	91975	broad.mit.edu	37	5	150275752	150275752	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:150275752T>A	ENST00000446148.2	-	7	1524	c.1097A>T	c.(1096-1098)gAa>gTa	p.E366V	ZNF300_ENST00000274599.5_Missense_Mutation_p.E350V|ZNF300_ENST00000418587.2_Missense_Mutation_p.E314V|ZNF300_ENST00000394226.2_Missense_Mutation_p.E350V|ZNF300_ENST00000427179.1_3'UTR	NM_001172831.1	NP_001166302.1	Q96RE9	ZN300_HUMAN	zinc finger protein 300	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E350V(1)		endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATAGGGTTTTTCCCCAGTGTG	0.413000													11	67					0	0	0.010729	0	0
KCTD7	154881	broad.mit.edu	37	7	66274076	66274076	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:66274076C>T	ENST00000380828.2	+	11	1555	c.1401C>T	c.(1399-1401)atC>atT	p.I467I	RABGEF1_ENST00000284957.5_Silent_p.I427I|RABGEF1_ENST00000439720.2_Silent_p.I440I|KCTD7_ENST00000510829.2_Silent_p.I427I|RABGEF1_ENST00000484547.2_3'UTR|RABGEF1_ENST00000437078.2_Silent_p.I441I|KCTD7_ENST00000451741.2_Silent_p.I427I|RABGEF1_ENST00000450873.2_Silent_p.I427I			Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	0						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.I427I(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						AAGAAAGGATCATGAATGAAG	0.403000													17	201					0	0	0.006122	0	0
RGL1	23179	broad.mit.edu	37	1	183876181	183876181	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:183876181A>T	ENST00000304685.3	+	15	2074	c.1613A>T	c.(1612-1614)gAc>gTc	p.D538V	RGL1_ENST00000539189.1_Missense_Mutation_p.D474V|RGL1_ENST00000536277.1_Missense_Mutation_p.D501V|RGL1_ENST00000367531.1_Missense_Mutation_p.D538V|RGL1_ENST00000360851.3_Missense_Mutation_p.D503V	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	503					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity	p.D538V(1)		breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						GCAGCTGCTGACGCCAGCACC	0.537000													12	20					0	0	0.002450	0	0
CASP7	840	broad.mit.edu	37	10	115481472	115481472	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:115481472C>T	ENST00000369321.2	+	5	729	c.409C>T	c.(409-411)Ctg>Ttg	p.L137L	CASP7_ENST00000369315.1_Silent_p.L104L|CASP7_ENST00000345633.4_Silent_p.L104L|CASP7_ENST00000369331.4_Silent_p.L104L|CASP7_ENST00000452490.2_Silent_p.L79L|CASP7_ENST00000369318.3_Silent_p.L104L	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	104					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding	p.L137L(1)		kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		CTTCCGAAGCCTGGGTTTTGA	0.507000													52	133					0	0	0.014410	0	0
TBX3	6926	broad.mit.edu	37	12	115111974	115111974	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:115111974G>A	ENST00000349155.2	-	6	2669	c.1706C>T	c.(1705-1707)tCt>tTt	p.S569F	TBX3_ENST00000257566.3_Missense_Mutation_p.S589F	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	589	Transcription repression.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding	p.S589F(1)		breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CCATACCTGAGAGGCCAGGAC	0.642000													5	8					0	0	0.000602	0	0
USP29	57663	broad.mit.edu	37	19	57640890	57640890	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:57640890C>A	ENST00000254181.4	+	4	1301	c.847C>A	c.(847-849)Ctg>Atg	p.L283M	USP29_ENST00000598197.1_Missense_Mutation_p.L283M	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	283					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.L283M(1)		breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCACAGCAACTGCAGCAGGG	0.463000													30	38					1.08312e-15	1.63267e-15	0.009535	1	0
ANKS4B	257629	broad.mit.edu	37	16	21262123	21262123	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:21262123G>T	ENST00000311620.5	+	2	1309	c.1236G>T	c.(1234-1236)ctG>ctT	p.L412L		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	412								p.L412L(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		CTGGGCAGCTGGTCGACACCA	0.567000													30	78					2.20474e-14	3.25613e-14	0.003755	1	0
GPRIN1	114787	broad.mit.edu	37	5	176026654	176026654	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:176026654G>T	ENST00000303991.4	-	2	359	c.182C>A	c.(181-183)cCt>cAt	p.P61H		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	61						growth cone|plasma membrane		p.P61H(1)		NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTTTGGTCAGGGGTGTGCCT	0.672000													22	151					4.59853e-10	5.88934e-10	0.005443	1	0
NMUR2	56923	broad.mit.edu	37	5	151784290	151784290	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:151784290C>G	ENST00000255262.3	-	1	550	c.385G>C	c.(385-387)Gtg>Ctg	p.V129L	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	129					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity	p.V129L(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GCGAAGCACACGGTCTCAAAG	0.622000													22	134					0	0	0.014323	0	0
SLC12A5	57468	broad.mit.edu	37	20	44683562	44683562	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:44683562G>A	ENST00000454036.1	+	21	2832	c.2756G>A	c.(2755-2757)aGc>aAc	p.S919N	SLC12A5_ENST00000243964.3_Missense_Mutation_p.S896N	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	919					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.S896N(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGCATGAGAGCGACATCTCA	0.557000													17	38					0	0	0.014323	0	0
SUV420H1	51111	broad.mit.edu	37	11	67941343	67941343	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:67941343C>G	ENST00000304363.4	-	6	934	c.581G>C	c.(580-582)gGa>gCa	p.G194A	SUV420H1_ENST00000402185.2_Missense_Mutation_p.G171A|SUV420H1_ENST00000401547.2_Missense_Mutation_p.G194A|SUV420H1_ENST00000405515.1_Missense_Mutation_p.G194A|SUV420H1_ENST00000402789.1_Missense_Mutation_p.G194A	NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	194	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.G194A(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						TATTTCAAATCCACTGTCAGT	0.308000													5	62					0	0	0.001984	0	0
ABRA	137735	broad.mit.edu	37	8	107773614	107773614	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:107773614C>G	ENST00000311955.3	-	2	851	c.797G>C	c.(796-798)aGt>aCt	p.S266T		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	266	Interaction with actin (By similarity).				positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding	p.S266T(1)		breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			AAACTCTTCACTGAAAGGATT	0.512000													14	74					0	0	0.002450	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954378	35954378	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:35954378T>C	ENST00000274278.3	-	7	1855	c.1498A>G	c.(1498-1500)Atg>Gtg	p.M500V		NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	500						integral to membrane	glucuronosyltransferase activity	p.M500V(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAAAGCCACATAGTGCCCAGA	0.592000													7	31					0	0	0.004482	0	0
SASH3	54440	broad.mit.edu	37	X	128926692	128926692	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:128926692C>G	ENST00000356892.3	+	6	795	c.681C>G	c.(679-681)atC>atG	p.I227M		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	227	SH3.							p.I227M(1)		breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						TCAAATTCATCTATGTGGATG	0.592000													24	110					0	0	0.014323	0	0
ASTN1	460	broad.mit.edu	37	1	176857281	176857281	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:176857281C>A	ENST00000367654.2	-	18	3037	c.3024G>T	c.(3022-3024)gaG>gaT	p.E1008D	ASTN1_ENST00000361833.2_Missense_Mutation_p.E1000D|ASTN1_ENST00000367657.3_Missense_Mutation_p.E1000D|ASTN1_ENST00000424564.2_Missense_Mutation_p.E1000D			O14525	ASTN1_HUMAN	astrotactin 1	1008					cell migration|neuron cell-cell adhesion	integral to membrane		p.E1000D(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GACACCAGTCCTCGATGACAT	0.532000													30	46					1.74807e-11	2.33839e-11	0.010818	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72434357	72434357	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:72434357C>A	ENST00000373208.1	+	2	128	c.128C>A	c.(127-129)cCc>cAc	p.P43H	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.P43H	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	43					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P43H(1)		NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GTGACAGTGCCCTGCAGCACA	0.567000													24	80					3.28513e-13	4.67604e-13	0.003954	1	0
VARS	7407	broad.mit.edu	37	6	31747922	31747922	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:31747922G>A	ENST00000375663.3	-	26	3374	c.2934C>T	c.(2932-2934)ggC>ggT	p.G978G		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	978					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity	p.G978G(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GGCTCTCATGGCCTCCGGGCT	0.647000													51	37					0	0	0.014410	0	0
AQR	9716	broad.mit.edu	37	15	35176875	35176875	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:35176875C>A	ENST00000156471.5	-	26	3103	c.2878G>T	c.(2878-2880)Gat>Tat	p.D960Y		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	960						catalytic step 2 spliceosome	RNA binding	p.D960Y(1)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TCCGTAACATCTGGCAATGTA	0.373000													28	34					6.02846e-25	1.03028e-24	0.003271	1	0
ST18	9705	broad.mit.edu	37	8	53038615	53038615	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:53038615C>A	ENST00000276480.7	-	23	3435	c.2752G>T	c.(2752-2754)Ggg>Tgg	p.G918W		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	918						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G918W(1)|p.G918R(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CTCTTACCCCCAGTTGCTTTG	0.493000													42	70					2.38262e-10	3.09015e-10	0.010771	1	0
CSMD1	64478	broad.mit.edu	37	8	3038632	3038632	+	Splice_Site	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:3038632T>G	ENST00000520002.1	-	38	6283	c.5728_splice	c.e38+1	p.T1910_splice	CSMD1_ENST00000542608.1_Splice_Site_p.T1909_splice|CSMD1_ENST00000602723.1_Splice_Site_p.T1910_splice|CSMD1_ENST00000539096.1_Splice_Site_p.T1909_splice|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000400186.3_Splice_Site_p.T1910_splice|CSMD1_ENST00000602557.1_Splice_Site_p.T1910_splice|CSMD1_ENST00000537824.1_Splice_Site_p.T1909_splice			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1910	CUB 11.					integral to membrane		p.T1909P(1)|p.T1638P(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTGACCTTACTTTTGTATTCC	0.378000													3	24					0	0	0.004672	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469602	120469602	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:120469602G>T	ENST00000283875.5	+	2	296	c.203G>T	c.(202-204)gGa>gTa	p.G68V		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	68	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding	p.G68V(1)		NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		AATTTAAAGGGAGACAAGTTT	0.413000													23	59					8.24728e-16	1.25055e-15	0.004656	1	0
PDK1	5163	broad.mit.edu	37	2	173429789	173429789	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:173429789G>T	ENST00000410055.1	+	5	779	c.679G>T	c.(679-681)Gaa>Taa	p.E227*	PDK1_ENST00000543905.1_Nonsense_Mutation_p.E151*|PDK1_ENST00000544863.1_Nonsense_Mutation_p.E72*|PDK1_ENST00000392571.2_Nonsense_Mutation_p.E247*|PDK1_ENST00000282077.2_Nonsense_Mutation_p.E227*	NM_002610.3	NP_002601.1	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase, isozyme 1	227	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity	p.E227*(1)		central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.12)			CAATGTACTTGAAGTTATTAA	0.289000									Autosomal Dominant Polycystic Kidney Disease				19	89					1.50039e-11	2.01763e-11	0.012319	1	0
PLCD3	113026	broad.mit.edu	37	17	43194110	43194110	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:43194110G>A	ENST00000322765.5	-	8	1415	c.1302C>T	c.(1300-1302)tgC>tgT	p.C434C	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	434	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.C434C(2)		breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	GCTCCAGCCCGCAGTGGTTCT	0.647000													10	42					0	0	0.008291	0	0
STX8	9482	broad.mit.edu	37	17	9281903	9281903	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:9281903C>A	ENST00000306357.3	-	7	1036	c.609G>T	c.(607-609)cgG>cgT	p.R203R	STX8_ENST00000574431.1_Silent_p.R92R	NM_004853.2	NP_004844.1	Q9UNK0	STX8_HUMAN	syntaxin 8	203	t-SNARE coiled-coil homology.				transport	endoplasmic reticulum|integral to plasma membrane		p.R203R(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(1)	12						CCATGTTTACCCGCCTGGTTT	0.423000													61	173					3.05417e-18	4.83183e-18	0.014410	1	0
FRMPD4	9758	broad.mit.edu	37	X	12735849	12735849	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:12735849G>T	ENST00000380682.1	+	16	3410	c.2904G>T	c.(2902-2904)tcG>tcT	p.S968S		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	968					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding	p.S958S(1)		breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAAAGTCCTCGCACGCCCTGG	0.602000													29	65					3.93418e-24	6.61305e-24	0.004289	1	0
CTAGE1	64693	broad.mit.edu	37	18	19996925	19996925	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:19996925T>A	ENST00000391403.2	-	1	953	c.850A>T	c.(850-852)Aag>Tag	p.K284*		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	284						integral to membrane		p.K284*(2)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					ATCAGTTTCTTCAAAGCTCCT	0.328000													13	59					0	0	0.013537	0	0
CCL28	56477	broad.mit.edu	37	5	43382065	43382065	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:43382065C>A	ENST00000361115.4	-	3	355	c.281G>T	c.(280-282)gGt>gTt	p.G94V	CCL28_ENST00000513525.1_Missense_Mutation_p.G47V	NM_148672.2	NP_683513.1	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28	94					chemotaxis|immune response	extracellular space	chemokine activity	p.G94V(1)		kidney(3)|lung(3)|ovary(1)	7						ATTTCCTTTACCATTTTTCTT	0.448000													40	152					1.57019e-19	2.49183e-19	0.007835	1	0
AGO2	27161	broad.mit.edu	37	8	141570586	141570586	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:141570586A>G	ENST00000220592.5	-	5	654	c.542T>C	c.(541-543)tTc>tCc	p.F181S	AGO2_ENST00000519980.1_Missense_Mutation_p.F181S	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2									p.F181S(1)									CGCGGTGAAGAAGGAGCGGCC	0.622000													9	73					0	0	0.010729	0	0
AGO2	27161	broad.mit.edu	37	8	141542158	141542158	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:141542158G>A	ENST00000220592.5	-	19	2677	c.2565C>T	c.(2563-2565)acC>acT	p.T855T	AGO2_ENST00000519980.1_Silent_p.T821T	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2									p.T855T(1)									CAAAGTACATGGTGCGCAGAG	0.547000													34	137					0	0	0.004878	0	0
SEC14L3	266629	broad.mit.edu	37	22	30866229	30866229	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr22:30866229G>T	ENST00000215812.4	-	3	234	c.144C>A	c.(142-144)gaC>gaA	p.D48E	SEC14L3_ENST00000401751.1_5'UTR|SEC14L3_ENST00000539629.1_5'UTR|SEC14L3_ENST00000540910.1_5'UTR|SEC14L3_ENST00000415957.2_5'UTR|SEC14L3_ENST00000402286.1_5'UTR|SEC14L3_ENST00000403066.1_5'UTR	NM_174975.4	NP_777635.1	Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	48						integral to membrane|intracellular	lipid binding|transporter activity	p.D48E(1)		NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	ACTTCTGCAAGTCAAAATTCC	0.537000													8	23					5.4927e-09	6.87934e-09	0.004482	1	0
NAALAD2	10003	broad.mit.edu	37	11	89883721	89883721	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:89883721C>T	ENST00000534061.1	+	5	785	c.555C>T	c.(553-555)aaC>aaT	p.N185N	NAALAD2_ENST00000375944.3_Silent_p.N185N|NAALAD2_ENST00000525171.1_Silent_p.N185N|NAALAD2_ENST00000321955.4_Silent_p.N185N	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	185					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity	p.N185N(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGGGCATCAACTGTACTGGGA	0.318000													31	60					0	0	0.012213	0	0
LRIT2	340745	broad.mit.edu	37	10	85984092	85984092	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:85984092C>A	ENST00000372113.4	-	2	894	c.889G>T	c.(889-891)Gat>Tat	p.D297Y	LRIT2_ENST00000538192.1_Missense_Mutation_p.D297Y	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	297	Ig-like.					integral to membrane		p.D297Y(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						GGCTTACCATCAAATTCTCTC	0.527000													12	27					4.3838e-07	5.30835e-07	0.001855	1	0
FBXO33	254170	broad.mit.edu	37	14	39870542	39870542	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:39870542C>G	ENST00000298097.7	-	3	1571	c.1234G>C	c.(1234-1236)Gat>Cat	p.D412H	FBXO33_ENST00000554190.1_Intron	NM_203301.3	NP_976046.1	Q7Z6M2	FBX33_HUMAN	F-box protein 33	412								p.D412H(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	9	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		GATATAAGATCAACAATAGCC	0.348000													13	75					0	0	0.002450	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121680905	121680905	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:121680905C>A	ENST00000393386.2	+	21	6084	c.5673C>A	c.(5671-5673)gtC>gtA	p.V1891V	PTPRZ1_ENST00000449182.1_Silent_p.V1024V	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1891	Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.V1891V(1)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GACGTGTGGTCACACAGTATC	0.517000													4	113					0.000602214	0.00066753	0.000602	1	0
DOLK	22845	broad.mit.edu	37	9	131708450	131708450	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:131708450T>C	ENST00000372586.3	-	1	1448	c.1133A>G	c.(1132-1134)tAc>tGc	p.Y378C	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	378					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity	p.Y378C(1)		breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						GATGCGGAAGTAGCGCACATA	0.527000													92	66					0	0	0.014410	0	0
TRIM41	90933	broad.mit.edu	37	5	180659677	180659677	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:180659677C>T	ENST00000315073.5	+	3	1638	c.928C>T	c.(928-930)Ctg>Ttg	p.L310L	TRIM41_ENST00000351937.5_Silent_p.L310L	NM_033549.4	NP_291027.3	Q8WV44	TRI41_HUMAN	tripartite motif containing 41	310						cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding	p.L310L(2)		NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAGTCAGAGCTGGCAGCGGT	0.552000													14	20					0	0	0.006122	0	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720852	31720852	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:31720852A>T	ENST00000334160.4	-	1	72	c.73T>A	c.(73-75)Tcc>Acc	p.S25T		NM_181624.1	NP_853655.1	A1A580	KR231_HUMAN	keratin associated protein 23-1	25						intermediate filament		p.S25T(1)		large_intestine(1)|lung(4)|prostate(1)	6						CCACCACGGGAGTAGCCTGAG	0.557000													28	39					0	0	0.007291	0	0
P2RY10	27334	broad.mit.edu	37	X	78216121	78216121	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:78216121C>A	ENST00000171757.2	+	4	384	c.104C>A	c.(103-105)tCc>tAc	p.S35Y	P2RY10_ENST00000544091.1_Missense_Mutation_p.S35Y|P2RY10_ENST00000475374.1_3'UTR	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	35						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.S35Y(1)		breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						TTTCAATACTCCCTCTATGCA	0.413000													46	81					7.88023e-25	1.34227e-24	0.014410	1	0
PAPPA2	60676	broad.mit.edu	37	1	176709310	176709310	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:176709310G>T	ENST00000367662.3	+	14	5293	c.4129G>T	c.(4129-4131)Ggg>Tgg	p.G1377W		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1377					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.G1377W(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGAGGACGAGGGGCAGAATCA	0.478000													7	53					0.000157383	0.000177534	0.003080	1	0
LRP1B	53353	broad.mit.edu	37	2	141208161	141208161	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:141208161C>G	ENST00000389484.3	-	63	11004	c.10033G>C	c.(10033-10035)Gga>Cga	p.G3345R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3345	LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G3345R(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCATCAGATCCATCACCACAG	0.348000										TSP Lung(27;0.18)			20	76					0	0	0.012319	0	0
OR4K17	390436	broad.mit.edu	37	14	20586105	20586105	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:20586105G>A	ENST00000315543.4	+	1	540	c.540G>A	c.(538-540)tgG>tgA	p.W180*		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W180_L181>*(1)		kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGACCTCATGGCTCTTGGGTC	0.453000													17	91					0	0	0.004990	0	0
EDEM3	80267	broad.mit.edu	37	1	184663205	184663205	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:184663205C>A	ENST00000318130.8	-	20	3057	c.2791G>T	c.(2791-2793)Gag>Tag	p.E931*	EDEM3_ENST00000367512.3_Nonsense_Mutation_p.E904*	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	931					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding	p.E888*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AGTCATAGCTCATCCTTCTCC	0.368000													5	68					0.000157383	0.000177534	0.003080	1	0
CYFIP2	26999	broad.mit.edu	37	5	156747733	156747733	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:156747733T>G	ENST00000347377.6	+	15	2025	c.1594T>G	c.(1594-1596)Ttg>Gtg	p.L532V	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000318218.6_Missense_Mutation_p.L532V|CYFIP2_ENST00000435847.2_Missense_Mutation_p.L206V|CYFIP2_ENST00000522463.1_Missense_Mutation_p.L336V|CYFIP2_ENST00000521420.1_Missense_Mutation_p.L506V|CYFIP2_ENST00000377576.3_Missense_Mutation_p.L532V|CYFIP2_ENST00000541131.1_Missense_Mutation_p.L457V	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	532					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding	p.L532V(3)		breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGACCCATGCTTGAGAGGGGA	0.582000													12	29					0	0	0.004007	0	0
AP2M1	1173	broad.mit.edu	37	3	183896907	183896907	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:183896907G>T	ENST00000382456.3	+	3	651	c.337G>T	c.(337-339)Gat>Tat	p.D113Y	AP2M1_ENST00000439647.1_Missense_Mutation_p.D113Y|EIF2B5_ENST00000444495.1_Intron|AP2M1_ENST00000411763.2_Missense_Mutation_p.D138Y|AP2M1_ENST00000292807.5_Missense_Mutation_p.D113Y	NM_001025205.1	NP_001020376.1	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	113					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity	p.D113Y(1)		endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	18	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGAGCTGCTGGATGGTGAGGC	0.547000													35	86					3.38236e-24	5.72313e-24	0.006999	1	0
TAAR5	9038	broad.mit.edu	37	6	132909856	132909856	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:132909856C>G	ENST00000258034.2	-	1	1021	c.970G>C	c.(970-972)Gtc>Ctc	p.V324L		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	324					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity	p.V324L(1)		breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GGTGAGAAGACCTTCTGGCTC	0.468000													32	44					0	0	0.010818	0	0
SPTB	6710	broad.mit.edu	37	14	65266574	65266574	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:65266574C>A	ENST00000389722.3	-	8	1008	c.955G>T	c.(955-957)Gag>Tag	p.E319*	SPTB_ENST00000389720.3_Nonsense_Mutation_p.E319*|SPTB_ENST00000542895.1_Nonsense_Mutation_p.E319*|SPTB_ENST00000556626.1_Nonsense_Mutation_p.E319*|SPTB_ENST00000389721.5_Nonsense_Mutation_p.E319*	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	319					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.E319K(1)|p.E319*(1)		breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ATGGTCTGCTCGATCCAGGTG	0.537000											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	99					1.57019e-19	2.49183e-19	0.007835	1	0
SORL1	6653	broad.mit.edu	37	11	121429318	121429318	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:121429318C>T	ENST00000260197.7	+	20	2811	c.2682C>T	c.(2680-2682)gaC>gaT	p.D894D		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	894					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity	p.D894D(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCTGGACAGACTGGGGAGACC	0.483000													24	246					0	0	0.003954	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326347	25326347	+	RNA	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:25326347A>T	ENST00000546682.1	+	0	47				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GGGCTCCTCCAGAGGCTGTTG	0.507000													16	11					0	0	0.004007	0	0
HDAC1	3065	broad.mit.edu	37	1	32796425	32796425	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:32796425G>T	ENST00000373548.3	+	9	979	c.895G>T	c.(895-897)Gga>Tga	p.G299*	HDAC1_ENST00000490081.1_3'UTR|HDAC1_ENST00000373541.2_Nonsense_Mutation_p.G106*	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	299	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity	p.G299*(1)		NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	GCTGATGCTGGGAGGCGGTGG	0.542000													20	59					1.64293e-13	2.39868e-13	0.003330	1	0
C1orf141	400757	broad.mit.edu	37	1	67558821	67558821	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:67558821G>C	ENST00000371007.2	-	8	1179	c.1070C>G	c.(1069-1071)aCg>aGg	p.T357R	C1orf141_ENST00000371006.1_Missense_Mutation_p.T357R|C1orf141_ENST00000544837.1_Missense_Mutation_p.T357R	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	357								p.T357R(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						GGGTATGCTCGTTGGTTTTCC	0.343000													23	91					0	0	0.003330	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28307030	28307030	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:28307030C>A	ENST00000284987.5	-	4	1565	c.1444G>T	c.(1444-1446)Ggc>Tgc	p.G482C	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	482					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding	p.G482C(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TCTTCGGGGCCCAGGATCTGC	0.527000													14	33					0.000151284	0.000172175	0.001855	1	0
HSPA8	3312	broad.mit.edu	37	11	122931962	122931962	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:122931962C>T	ENST00000534624.1	-	2	347	c.71G>A	c.(70-72)gGa>gAa	p.G24E	HSPA8_ENST00000526110.1_Missense_Mutation_p.G24E|HSPA8_ENST00000227378.3_Missense_Mutation_p.G24E|HSPA8_ENST00000533540.1_Missense_Mutation_p.G24E|HSPA8_ENST00000453788.2_Missense_Mutation_p.G24E|HSPA8_ENST00000532636.1_Missense_Mutation_p.G24E	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	24					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding	p.G24E(1)		breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTCGACTTTTCCGTGCTGGAA	0.463000													9	87					0	0	0.006214	0	0
OLFM3	118427	broad.mit.edu	37	1	102269934	102269934	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:102269934G>T	ENST00000370103.4	-	6	1450	c.1237C>A	c.(1237-1239)Ccc>Acc	p.P413T	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000536598.1_3'UTR|OLFM3_ENST00000338858.5_Missense_Mutation_p.P433T	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	433	Olfactomedin-like.					extracellular region		p.P413T(1)|p.P433T(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTATGGAAGGGAATGTCTGTG	0.448000													28	156					9.8876e-21	1.6091e-20	0.004878	1	0
BACH1	571	broad.mit.edu	37	21	30714991	30714991	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:30714991G>T	ENST00000399921.1	+	5	2291	c.2048G>T	c.(2047-2049)tGt>tTt	p.C683F	BACH1_ENST00000286800.3_Missense_Mutation_p.C683F	NM_206866.1	NP_996749.1	O14867	BACH1_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 1	683						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.C683F(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|urinary_tract(2)	27						CTGCCTCCCTGTGCCAGAGGA	0.527000													15	54					1.5739e-10	2.05169e-10	0.004007	1	0
RELN	5649	broad.mit.edu	37	7	103205892	103205892	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:103205892A>C	ENST00000428762.1	-	34	5202	c.5043T>G	c.(5041-5043)agT>agG	p.S1681R	RELN_ENST00000424685.2_Missense_Mutation_p.S1681R|RELN_ENST00000343529.5_Missense_Mutation_p.S1681R	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1681					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.S1681R(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGAGCTGTACACTGTGGGAGT	0.478000													6	59					0	0	0.001168	0	0
MYO3A	53904	broad.mit.edu	37	10	26465695	26465695	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:26465695G>A	ENST00000265944.5	+	31	4525	c.4359G>A	c.(4357-4359)caG>caA	p.Q1453Q	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1453					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.Q1453Q(1)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TTTTGTCACAGCAACTGAAGT	0.358000													3	67					0	0	0.004672	0	0
CACNA1E	777	broad.mit.edu	37	1	181706768	181706768	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:181706768T>A	ENST00000526775.1	+	22	3638	c.3473T>A	c.(3472-3474)cTg>cAg	p.L1158Q	CACNA1E_ENST00000367570.1_Missense_Mutation_p.L1177Q|CACNA1E_ENST00000367573.2_Missense_Mutation_p.L1177Q|CACNA1E_ENST00000357570.5_Missense_Mutation_p.L1128Q|CACNA1E_ENST00000367567.4_Missense_Mutation_p.L784Q|CACNA1E_ENST00000358338.5_Missense_Mutation_p.L1109Q|CACNA1E_ENST00000360108.3_Missense_Mutation_p.L1158Q	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1177					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.L1177K(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GACCCCGTCCTGACCAACTCG	0.612000													76	105					0	0	0.014410	0	0
GABRA1	2554	broad.mit.edu	37	5	161302634	161302634	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:161302634T>A	ENST00000428797.2	+	7	900	c.545T>A	c.(544-546)cTa>cAa	p.L182Q	GABRA1_ENST00000023897.6_Missense_Mutation_p.L182Q|GABRA1_ENST00000444819.1_Missense_Mutation_p.L182Q|GABRA1_ENST00000437025.2_Missense_Mutation_p.L182Q|GABRA1_ENST00000393943.4_Missense_Mutation_p.L182Q|GABRA1_ENST00000420560.1_Missense_Mutation_p.L182Q	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	182					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.L182Q(1)		NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GCTTGCCCACTAAAATTTGGA	0.398000													18	93					0	0	0.007413	0	0
DOCK2	1794	broad.mit.edu	37	5	169469116	169469116	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:169469116G>A	ENST00000256935.8	+	38	3936	c.3856G>A	c.(3856-3858)Ggc>Agc	p.G1286S	DOCK2_ENST00000520908.1_Missense_Mutation_p.G778S|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.G347S	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1286	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding	p.G1286S(1)		NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACCATCATAGGCTACTTTGA	0.572000													11	16					0	0	0.013537	0	0
OR2W3	343171	broad.mit.edu	37	1	248059635	248059635	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:248059635C>A	ENST00000537741.1	+	3	1004	c.747C>A	c.(745-747)tcC>tcA	p.S249S	OR2W3_ENST00000360358.3_Silent_p.S249S			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S249S(1)		breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTGTGGTCTCCCTTTTCTATG	0.512000													27	169					3.73808e-20	6.02574e-20	0.005443	1	0
ZNF516	9658	broad.mit.edu	37	18	74091436	74091436	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:74091436C>A	ENST00000443185.2	-	4	2951	c.2634G>T	c.(2632-2634)tgG>tgT	p.W878C	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	878					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.W878C(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGCCGGGCGCCCACAGAGCGC	0.647000													23	77					1.1804e-14	1.74836e-14	0.003954	1	0
TSSK1B	83942	broad.mit.edu	37	5	112769842	112769842	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:112769842C>A	ENST00000390666.3	-	1	886	c.695G>T	c.(694-696)cGc>cTc	p.R232L	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	232	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.R232H(1)|p.R232L(1)		large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GAAGTTGACGCGGTGCTCCTT	0.587000													33	43					5.90632e-09	7.37929e-09	0.012213	1	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	G	rs11540652		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:7577538C>G	ENST00000420246.2	-	7	875	c.743G>C	c.(742-744)cGg>cCg	p.R248P	TP53_ENST00000269305.4_Missense_Mutation_p.R248P|TP53_ENST00000445888.2_Missense_Mutation_p.R248P|TP53_ENST00000359597.4_Missense_Mutation_p.R248P|TP53_ENST00000413465.2_Missense_Mutation_p.R248P|TP53_ENST00000455263.2_Missense_Mutation_p.R248P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	43					0	0	0.014410	0	0
SMARCA1	6594	broad.mit.edu	37	X	128633819	128633819	+	Splice_Site	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:128633819C>G	ENST00000371122.4	-	10	1297		c.e10-1		SMARCA1_ENST00000371123.1_Splice_Site|SMARCA1_ENST00000371121.3_Splice_Site	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding	p.?(1)		biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						GTTTTAAAACCTAAAAGGTGA	0.289000													28	140					0	0	0.005443	0	0
KNTC1	9735	broad.mit.edu	37	12	123072257	123072257	+	Splice_Site	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:123072257G>T	ENST00000333479.7	+	39	3907		c.e39-1		KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding	p.?(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TCACTCTGCAGGAGATGGCCT	0.378000													16	10					1.5739e-10	2.05169e-10	0.004007	1	0
CTNNA2	1496	broad.mit.edu	37	2	80831226	80831226	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:80831226T>A	ENST00000466387.1	+	20	2941	c.2217T>A	c.(2215-2217)tcT>tcA	p.S739S	AC008067.2_ENST00000596783.1_RNA|CTNNA2_ENST00000361291.4_Silent_p.S773S|AC008067.2_ENST00000595478.1_RNA|CTNNA2_ENST00000541047.1_Silent_p.S739S|CTNNA2_ENST00000402739.4_Silent_p.S739S|CTNNA2_ENST00000540488.1_Silent_p.S739S|AC008067.2_ENST00000599412.1_RNA|AC008067.2_ENST00000430876.1_RNA|AC008067.2_ENST00000596887.1_RNA|CTNNA2_ENST00000343114.3_Silent_p.S418S|CTNNA2_ENST00000496558.1_Silent_p.S739S			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	739					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.S739S(1)|p.D740E(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAAATACATCTGATGTCATTA	0.418000													10	43					0	0	0.004007	0	0
KBTBD2	25948	broad.mit.edu	37	7	32910171	32910171	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:32910171T>C	ENST00000304056.4	-	4	1357	c.658A>G	c.(658-660)Atc>Gtc	p.I220V	AVL9_ENST00000404479.1_Intron	NM_015483.2	NP_056298.2	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	220								p.I220V(1)		endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|urinary_tract(1)	17			GBM - Glioblastoma multiforme(11;0.0499)			TCAATTCTGATTTGGCTAAGA	0.418000													14	57					0	0	0.003163	0	0
ROBO3	64221	broad.mit.edu	37	11	124738967	124738967	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:124738967G>T	ENST00000397801.1	+	2	622	c.430G>T	c.(430-432)Gtg>Ttg	p.V144L	ROBO3_ENST00000538940.1_Missense_Mutation_p.V122L	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	144	Ig-like C2-type 1.				axon midline choice point recognition	integral to membrane	receptor activity	p.V144L(2)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTACACTTGCGTGGCTCGCAA	0.682000													7	8					1.76689e-08	2.17562e-08	0.006214	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58549360	58549360	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:58549360G>T	ENST00000282326.1	+	3	403	c.156G>T	c.(154-156)ccG>ccT	p.P52P	ZSCAN1_ENST00000391700.1_Silent_p.P52P|ZSCAN1_ENST00000601162.1_Silent_p.P52P	NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	52	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P52P(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGAGCGGGCCGCACCTCGCGC	0.701000													7	6					5.16669e-11	6.8576e-11	0.010729	1	0
OR10T2	128360	broad.mit.edu	37	1	158368639	158368639	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:158368639C>A	ENST00000334438.1	-	1	617	c.618G>T	c.(616-618)ctG>ctT	p.L206L		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L206L(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CCATAATTACCAGGATGCTGA	0.448000													15	24					0.00498961	0.00539046	0.004990	1	0
PLEKHA6	22874	broad.mit.edu	37	1	204214839	204214839	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:204214839G>T	ENST00000272203.3	-	14	2252	c.1936C>A	c.(1936-1938)Cgg>Agg	p.R646R	PLEKHA6_ENST00000414478.1_Silent_p.R666R	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	646								p.R646R(1)		breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TGGATTTGCCGGTTCAGCACC	0.582000													30	44					1.34939e-06	1.60731e-06	0.003271	1	0
ARAP2	116984	broad.mit.edu	37	4	36150077	36150077	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:36150077C>T	ENST00000303965.4	-	17	3439	c.2950G>A	c.(2950-2952)Gga>Aga	p.G984R		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	984	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding	p.G984R(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GTTTCAGCTCCAAATAAAAAC	0.353000													9	15					0	0	0.008291	0	0
CIITA	4261	broad.mit.edu	37	16	11000871	11000871	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:11000871G>C	ENST00000324288.8	+	11	1655	c.1522G>C	c.(1522-1524)Gat>Cat	p.D508H	CIITA_ENST00000381835.5_Intron|CIITA_ENST00000537380.1_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	508	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding	p.D508H(1)		central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GGAAGCGCAAGATGGCTTCCT	0.637000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								15	81					0	0	0.004007	0	0
CELSR2	1952	broad.mit.edu	37	1	109810586	109810586	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:109810586C>T	ENST00000271332.3	+	17	6283	c.6222C>T	c.(6220-6222)gtC>gtT	p.V2074V		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2074					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding	p.V2074V(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCAGCGACGTCAAGGTGGCCT	0.662000													4	29					0	0	0.003080	0	0
NAE1	8883	broad.mit.edu	37	16	66850922	66850922	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:66850922G>A	ENST00000379463.2	-	11	868	c.676C>T	c.(676-678)Cga>Tga	p.R226*	NAE1_ENST00000290810.3_Nonsense_Mutation_p.R232*|NAE1_ENST00000394074.2_Nonsense_Mutation_p.R143*|NAE1_ENST00000359087.4_Nonsense_Mutation_p.R235*	NM_001018159.1	NP_001018169.1	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1	232					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity	p.R232*(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TTAGGTATTCGTCCATTTGTC	0.274000													5	46					0	0	0.000602	0	0
SCNM1	79005	broad.mit.edu	37	1	151139642	151139642	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:151139642A>G	ENST00000368905.4	+	4	368	c.257A>G	c.(256-258)aAg>aGg	p.K86R	SCNM1_ENST00000461862.1_3'UTR	NM_001204856.1|NM_024041.3	NP_001191785.1|NP_076946.1	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	86					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding	p.K86R(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AAGGAAAGAAAGCAGAATCCA	0.463000													38	137					0	0	0.009718	0	0
C1orf94	84970	broad.mit.edu	37	1	34684357	34684357	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:34684357T>G	ENST00000488417.1	+	7	1912	c.1792T>G	c.(1792-1794)Ttt>Gtt	p.F598V	C1orf94_ENST00000373374.3_Missense_Mutation_p.F408V	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	408							protein binding	p.F408V(1)|p.F598V(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				TGGCATAAACTTTTAGATCTC	0.498000													19	79					0	0	0.012319	0	0
SNHG10	283596	broad.mit.edu	37	14	95999655	95999655	+	RNA	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:95999655T>A	ENST00000500370.2	-	0	766				SNHG10_ENST00000555866.1_RNA|SNHG10_ENST00000554169.1_RNA|SNHG10_ENST00000553559.1_RNA																							CCAGCAACATTGTAAAAAAAT	0.338000													17	98					0	0	0.007413	0	0
FGF13	2258	broad.mit.edu	37	X	137793019	137793019	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:137793019G>T	ENST00000315930.6	-	1	808	c.147C>A	c.(145-147)gtC>gtA	p.V49V	FGF13_ENST00000441825.2_Intron|FGF13_ENST00000541469.1_Intron|FGF13_ENST00000370603.3_Intron|FGF13_ENST00000305414.4_Intron	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	49					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity	p.V49V(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					CGAAGAGTTTGACCCGGGAAA	0.547000													31	163					8.16721e-17	1.25706e-16	0.010818	1	0
HDAC9	9734	broad.mit.edu	37	7	18869106	18869106	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:18869106G>T	ENST00000406451.3	+	19	2542	c.2392G>T	c.(2392-2394)Gtt>Ttt	p.V798F	HDAC9_ENST00000401921.1_Missense_Mutation_p.V757F|HDAC9_ENST00000441542.2_Missense_Mutation_p.V801F|HDAC9_ENST00000432645.2_Missense_Mutation_p.V798F	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	798	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.V801F(2)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTTTAATTCAGTTGCAATTAC	0.363000													24	49					9.80776e-20	1.56618e-19	0.006320	1	0
CACNG8	59283	broad.mit.edu	37	19	54466459	54466459	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:54466459G>T	ENST00000270458.2	+	1	166	c.63G>T	c.(61-63)gtG>gtT	p.V21V		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	21					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.V21V(1)		kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GGGTGCAGGTGCTGCTGACGA	0.672000													6	8					5.18039e-06	6.08547e-06	0.003080	1	0
GRIN3A	116443	broad.mit.edu	37	9	104433015	104433015	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:104433015C>A	ENST00000361820.3	-	3	2279	c.1679G>T	c.(1678-1680)aGc>aTc	p.S560I		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	560					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding	p.S560I(1)		breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCTATGGAGGCTGCTAAAAAG	0.443000													33	29					4.34311e-12	5.96593e-12	0.003271	1	0
WDR49	151790	broad.mit.edu	37	3	167246840	167246840	+	Splice_Site	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:167246840C>A	ENST00000308378.3	-	10	1655	c.1350_splice	c.e10+1	p.E450_splice	WDR49_ENST00000453925.2_Splice_Site_p.E514_splice|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Splice_Site_p.E275_splice	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	450								p.E450D(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TTCAATTTACCTCTATATTCC	0.358000													11	28					1.52009e-12	2.12813e-12	0.003163	1	0
ZBTB7B	51043	broad.mit.edu	37	1	154988888	154988888	+	Silent	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:154988888C>G	ENST00000368426.3	+	4	1484	c.1347C>G	c.(1345-1347)ctC>ctG	p.L449L	ZBTB7B_ENST00000292176.2_Silent_p.L449L|ZBTB7B_ENST00000417934.2_Silent_p.L483L|ZBTB7B_ENST00000535420.1_Silent_p.L449L	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	449					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.L449L(1)		endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGCGCCACCTCAAAGGCCAGA	0.652000													5	63					0	0	0.000602	0	0
DARC	2532	broad.mit.edu	37	1	159175317	159175317	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:159175317T>A	ENST00000537147.1	+	3	931	c.88T>A	c.(88-90)Tat>Aat	p.Y30N	DARC_ENST00000368122.2_Missense_Mutation_p.Y30N|DARC_ENST00000368121.2_Missense_Mutation_p.Y32N			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	30					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity	p.Y32H(1)|p.Y32N(1)		large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GAATTCTTCCTATGGTGTGAA	0.542000													18	102					0	0	0.008871	0	0
TXNDC16	57544	broad.mit.edu	37	14	52923870	52923870	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:52923870T>A	ENST00000281741.4	-	17	2012	c.1641A>T	c.(1639-1641)gcA>gcT	p.A547A	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	547					cell redox homeostasis	extracellular region		p.A547A(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					GGTAGTTTCCTGCTTCACTAA	0.294000													20	49					0	0	0.008871	0	0
MECP2	4204	broad.mit.edu	37	X	153296370	153296370	+	Missense_Mutation	SNP	G	G	C	rs63749747		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:153296370G>C	ENST00000303391.6	-	4	1158	c.909C>G	c.(907-909)atC>atG	p.I303M	MECP2_ENST00000453960.2_Missense_Mutation_p.I315M	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	303					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity	p.I303M(1)		breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCGCTTCTTGATGGGGAGTA	0.602000													34	132					0	0	0.003755	0	0
PCDH15	65217	broad.mit.edu	37	10	55581628	55581628	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:55581628G>T	ENST00000361849.3	-	34	6258	c.5864C>A	c.(5863-5865)aCt>aAt	p.T1955N	PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.T1953N|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.T1930N|PCDH15_ENST00000395430.1_Missense_Mutation_p.T1950N|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.T1884N|PCDH15_ENST00000373957.3_Missense_Mutation_p.T807N|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.T1913N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1953					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.T1953N(1)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTACAGTGAAGTAGATTGACT	0.353000										HNSCC(58;0.16)			14	58					1.49906e-05	1.73308e-05	0.002450	1	0
STAB2	55576	broad.mit.edu	37	12	104100609	104100609	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:104100609C>A	ENST00000388887.2	+	38	4240	c.4036C>A	c.(4036-4038)Cag>Aag	p.Q1346K		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1346	Laminin EGF-like 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.Q1346K(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCCCCAATGCCAGCCCTGCCC	0.547000													67	37					1.93348e-29	3.41871e-29	0.014410	1	0
GRM7	2917	broad.mit.edu	37	3	7721839	7721839	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:7721839C>A	ENST00000486284.1	+	9	2829	c.2555C>A	c.(2554-2556)cCt>cAt	p.P852H	GRM7_ENST00000403881.1_Missense_Mutation_p.P852H|GRM7_ENST00000389336.4_Missense_Mutation_p.P852H|GRM7_ENST00000402647.2_Missense_Mutation_p.P852H|GRM7_ENST00000357716.4_Missense_Mutation_p.P852H	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	852					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.P852H(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	ATTTTCCACCCTGAACTCAAT	0.493000													25	34					2.79863e-10	3.62051e-10	0.004656	1	0
RFWD2	64326	broad.mit.edu	37	1	175957481	175957481	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:175957481G>A	ENST00000367669.3	-	17	2429	c.1915C>T	c.(1915-1917)Cat>Tat	p.H639Y	RFWD2_ENST00000308769.8_Missense_Mutation_p.H615Y	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	639					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.H639Y(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TCATTGATATGACCCTTGAAG	0.393000													36	30					0	0	0.004878	0	0
HKDC1	80201	broad.mit.edu	37	10	71005913	71005913	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:71005913C>T	ENST00000354624.5	+	8	1087	c.954C>T	c.(952-954)ctC>ctT	p.L318L	HKDC1_ENST00000395086.2_Silent_p.L318L	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	318					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity	p.L318L(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						AGGCTGGCCTCCTGTTTGGTG	0.537000													27	69					0	0	0.005443	0	0
LVRN	206338	broad.mit.edu	37	5	115351451	115351451	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:115351451T>A	ENST00000357872.4	+	18	2869	c.2745T>A	c.(2743-2745)gcT>gcA	p.A915A	AQPEP_ENST00000515454.1_3'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		915					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding	p.A915A(1)									ACTGGCAAGCTGTGAGTAAAA	0.423000													14	21					0	0	0.002450	0	0
DGAT1	8694	broad.mit.edu	37	8	145541627	145541627	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:145541627G>T	ENST00000332324.4	-	9	1078	c.805C>A	c.(805-807)Cgc>Agc	p.R269S	DGAT1_ENST00000531896.1_Missense_Mutation_p.P299Q	NM_012079.4	NP_036211.2	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	269					triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity	p.R269S(1)		breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	9	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CGGGGAGAGCGGGGAAAGTTG	0.622000													16	46					5.03518e-11	6.70047e-11	0.007413	1	0
CYP4F8	11283	broad.mit.edu	37	19	15734084	15734084	+	RNA	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:15734084G>T	ENST00000441682.2	+	0	878							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding	p.E272*(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CGTCATCCAGGAGCGGCGCCG	0.577000													23	29					2.2171e-23	3.67837e-23	0.009535	1	0
AKAP6	9472	broad.mit.edu	37	14	33046386	33046386	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:33046386G>T	ENST00000280979.4	+	5	2577	c.2407G>T	c.(2407-2409)Gaa>Taa	p.E803*	AKAP6_ENST00000557272.1_Nonsense_Mutation_p.E803*|AKAP6_ENST00000557354.1_Nonsense_Mutation_p.E803*	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	803					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding	p.E803*(1)		NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGAAACTACAGAAAATTGGAC	0.393000													23	141					6.44725e-10	8.23636e-10	0.014323	1	0
ERC2	26059	broad.mit.edu	37	3	55922479	55922479	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:55922479T>G	ENST00000288221.6	-	14	2757	c.2502A>C	c.(2500-2502)gaA>gaC	p.E834D		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	834						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding	p.E834D(2)		breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCAAGTGCGCTTCTTTTTCGG	0.532000													75	85					0	0	0.014410	0	0
SLC39A11	201266	broad.mit.edu	37	17	70845835	70845835	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:70845835C>A	ENST00000542342.2	-	6	648	c.560G>T	c.(559-561)gGc>gTc	p.G187V	SLC39A11_ENST00000255559.3_Missense_Mutation_p.G180V|SLC39A11_ENST00000579732.1_Missense_Mutation_p.G180V	NM_001159770.1	NP_001153242.1	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11	187					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity	p.G180V(1)		endometrium(1)|large_intestine(4)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16						GCTGCTGCCGCCGGGCTGTGC	0.597000													35	88					4.67007e-22	7.67332e-22	0.008740	1	0
VPS13A	23230	broad.mit.edu	37	9	79853290	79853290	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:79853290A>G	ENST00000360280.3	+	19	2148	c.1888A>G	c.(1888-1890)Aag>Gag	p.K630E	VPS13A_ENST00000357409.5_Missense_Mutation_p.K630E|VPS13A_ENST00000376634.4_Missense_Mutation_p.K630E|VPS13A_ENST00000376636.3_Missense_Mutation_p.K630E	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	630					Golgi to endosome transport|protein transport	intracellular	protein binding	p.K630E(3)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATTTCGCAGTAAGACAGCAAC	0.333000													21	18					0	0	0.010504	0	0
SETDB1	9869	broad.mit.edu	37	1	150935079	150935079	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:150935079C>G	ENST00000271640.5	+	18	3365	c.3175C>G	c.(3175-3177)Cga>Gga	p.R1059G	SETDB1_ENST00000368969.4_Missense_Mutation_p.R1059G	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	1059	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding	p.R1059G(1)		NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAAAGCTCTCGAAATTACGG	0.478000													63	87					0	0	0.014410	0	0
SEPT2	4735	broad.mit.edu	37	2	242276804	242276804	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:242276804A>G	ENST00000391973.2	+	6	877	c.349A>G	c.(349-351)Aca>Gca	p.T117A	SEPT2_ENST00000360051.3_Missense_Mutation_p.T117A|SEPT2_ENST00000407971.1_Missense_Mutation_p.T77A|SEPT2_ENST00000401990.1_Missense_Mutation_p.T127A|SEPT2_ENST00000391971.2_Missense_Mutation_p.T117A|SEPT2_ENST00000402092.2_Missense_Mutation_p.T117A	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	117					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding	p.T117A(1)		central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		CAGTTTTAAGACAATTATCTC	0.413000													19	131					0	0	0.010504	0	0
SLC15A2	6565	broad.mit.edu	37	3	121634151	121634151	+	Silent	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:121634151A>G	ENST00000489711.1	+	6	994	c.606A>G	c.(604-606)acA>acG	p.T202T	SLC15A2_ENST00000295605.2_Silent_p.T171T	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	202					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding	p.T202T(1)		NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CATTTATCACACCCATGCTGA	0.443000													16	85					0	0	0.004990	0	0
SNHG14	104472715	broad.mit.edu	37	15	25458686	25458686	+	RNA	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:25458686G>T	ENST00000424208.1	+	0	2643				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						AGCCCCTGGTGCACTGAAGCT	0.602000													15	18					3.27435e-08	4.01246e-08	0.002450	1	0
SFMBT2	57713	broad.mit.edu	37	10	7214469	7214469	+	Silent	SNP	C	C	A	rs145957081	byFrequency	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:7214469C>A	ENST00000361972.4	-	18	2229	c.2139G>T	c.(2137-2139)gcG>gcT	p.A713A	SFMBT2_ENST00000397167.1_Silent_p.A713A	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	713					regulation of transcription, DNA-dependent	nucleus		p.A713A(1)		NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						CCCCCGAGCCCGCGGTGAAGT	0.642000													8	20					5.4927e-09	6.87934e-09	0.004482	1	0
KHDRBS3	10656	broad.mit.edu	37	8	136594267	136594267	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:136594267G>A	ENST00000355849.5	+	6	1168	c.758G>A	c.(757-759)gGg>gAg	p.G253E	KHDRBS3_ENST00000520981.1_Intron	NM_006558.1	NP_006549.1	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal transduction associated 3	253	Pro-rich.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding	p.G253E(1)		NS(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	26	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			CCCCCAACTGGGTACAGACCT	0.557000													16	35					0	0	0.003163	0	0
TRAV7	28686	broad.mit.edu	37	14	22251572	22251572	+	RNA	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:22251572G>T	ENST00000390429.3	+	0	189																											ATACAGGGATGGGTCCCAAAC	0.443000													29	26					1.22384e-17	1.92425e-17	0.013726	1	0
MAPK10	5602	broad.mit.edu	37	4	87080500	87080500	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:87080500G>A	ENST00000395169.3	-	4	793	c.73C>T	c.(73-75)Cgc>Tgc	p.R25C	MAPK10_ENST00000361569.2_Missense_Mutation_p.R63C|RP11-778J15.1_ENST00000511917.1_RNA|MAPK10_ENST00000359221.3_Missense_Mutation_p.R63C|MAPK10_ENST00000395166.1_Missense_Mutation_p.R25C|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000395161.2_Missense_Mutation_p.R63C|MAPK10_ENST00000449047.2_5'UTR	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	63					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding	p.R63C(1)		breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TTCTGGTAGCGCTTGAGAACT	0.443000													28	71					0	0	0.009535	0	0
MGAM	8972	broad.mit.edu	37	7	141762468	141762468	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:141762468C>A	ENST00000475668.2	+	35	4277	c.4223C>A	c.(4222-4224)cCa>cAa	p.P1408Q	MGAM_ENST00000549489.2_Missense_Mutation_p.P1408Q			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1408	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.P1408Q(3)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCACAGAATCCAGAGAGGAGC	0.428000													61	33					1.34159e-35	2.43969e-35	0.014410	1	0
ADAMTS19	171019	broad.mit.edu	37	5	129040017	129040017	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:129040017C>T	ENST00000274487.4	+	21	3372	c.3227C>T	c.(3226-3228)cCc>cTc	p.P1076L	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1076	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P1076L(1)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TCTACCAGACCCAGGGAGGCT	0.458000													76	122					0	0	0.014410	0	0
MS4A12	54860	broad.mit.edu	37	11	60264840	60264840	+	Missense_Mutation	SNP	C	C	T	rs138899173		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:60264840C>T	ENST00000016913.4	+	2	106	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	MS4A12_ENST00000525951.1_3'UTR|MS4A12_ENST00000537076.1_Missense_Mutation_p.P17S	NM_017716.2	NP_060186.2	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member 12	17						integral to membrane	receptor activity	p.P17S(1)		breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						TGAAACCATACCCAACCCTTA	0.433000													29	113					0	0	0.006999	0	0
OR2M4	26245	broad.mit.edu	37	1	248402987	248402987	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:248402987G>C	ENST00000306687.1	+	1	757	c.757G>C	c.(757-759)Ggt>Cgt	p.G253R		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G253R(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACTCTACTACGGTGCTGCTAT	0.537000													12	70					0	0	0.001855	0	0
GOT2	2806	broad.mit.edu	37	16	58752583	58752583	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:58752583A>C	ENST00000245206.5	-	5	573	c.445T>G	c.(445-447)Ttt>Gtt	p.F149V	GOT2_ENST00000564400.1_5'UTR|GOT2_ENST00000434819.2_Missense_Mutation_p.F106V	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	149					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding	p.F149V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGAACTTAAAAAATCTTTGC	0.408000													19	87					0	0	0.012319	0	0
MROH8	140699	broad.mit.edu	37	20	35749391	35749391	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:35749391C>T	ENST00000400441.3	-	16	2024	c.2025G>A	c.(2023-2025)ttG>ttA	p.L675L	MROH8_ENST00000217333.8_Silent_p.L504L|MROH8_ENST00000441008.2_Silent_p.L661L					maestro heat-like repeat family member 8									p.L675L(1)									TGAATTCCTGCAAGCAGCATG	0.463000													15	36					0	0	0.004990	0	0
MACC1	346389	broad.mit.edu	37	7	20198853	20198853	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:20198853G>A	ENST00000400331.5	-	5	1439	c.1131C>T	c.(1129-1131)ccC>ccT	p.P377P	MACC1_ENST00000332878.4_Silent_p.P377P|MACC1_ENST00000589011.1_Silent_p.P377P	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	377					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity	p.P377P(1)		endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GGATATATTTGGGTCCATAAA	0.393000													16	20					0	0	0.006122	0	0
TNR	7143	broad.mit.edu	37	1	175335155	175335155	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:175335155C>A	ENST00000367674.1	-	11	2881	c.2173G>T	c.(2173-2175)Ggg>Tgg	p.G725W	TNR_ENST00000263525.2_Missense_Mutation_p.G725W	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	725	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.G725W(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GAGGCAATCCCAGAGGATGGG	0.547000													12	135					2.80697e-09	3.55041e-09	0.010729	1	0
THSD7A	221981	broad.mit.edu	37	7	11501699	11501699	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:11501699A>T	ENST00000423059.3	-	10	2691	c.2440T>A	c.(2440-2442)Tgc>Agc	p.C814S	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	814	TSP type-1 8.					integral to membrane		p.C814S(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGATCTGTGCAGTCTCGGCCC	0.537000										HNSCC(18;0.044)			28	114					0	0	0.008361	0	0
GDF6	392255	broad.mit.edu	37	8	97156985	97156985	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:97156985G>C	ENST00000287020.5	-	2	1273	c.1174C>G	c.(1174-1176)Cgc>Ggc	p.R392G		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	392					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity	p.R392C(1)|p.R392G(1)		breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					AGGTGCGAGCGCAGCGGGAAG	0.632000													22	22					0	0	0.002780	0	0
ABCA12	26154	broad.mit.edu	37	2	215833452	215833452	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:215833452G>T	ENST00000272895.7	-	38	5989	c.5770C>A	c.(5770-5772)Ctt>Att	p.L1924I	ABCA12_ENST00000389661.4_Missense_Mutation_p.L1606I	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1924					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.L1924I(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACCTTGGCAAGTGTTCTATTG	0.333000													4	36					0.000274275	0.000308032	0.004482	1	0
MALT1	10892	broad.mit.edu	37	18	56363658	56363658	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:56363658T>C	ENST00000348428.3	+	3	695	c.437T>C	c.(436-438)cTg>cCg	p.L146P	MALT1_ENST00000345724.3_Missense_Mutation_p.L146P|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	146	Ig-like C2-type 1.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity	p.L146P(1)		central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						TTTGTGAAACTGTGTTGCCGG	0.308000			T	BIRC3	MALT								5	29					0	0	0.001168	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563490	140563490	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:140563490C>T	ENST00000361016.2	+	1	2511	c.1356C>T	c.(1354-1356)acC>acT	p.T452T		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		452					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.T452T(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACTTTCACCCAAACCTCCT	0.567000													57	128					0	0	0.014410	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156910213	156910213	+	Silent	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:156910213A>C	ENST00000368194.3	-	36	4558	c.3519T>G	c.(3517-3519)acT>acG	p.T1173T	ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000361409.2_Silent_p.T1133T|ARHGEF11_ENST00000315174.8_Silent_p.T549T	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1133					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	p.T1173T(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTGGGACCCAGTGCCTGTTT	0.602000													11	46					0	0	0.010729	0	0
CDK6	1021	broad.mit.edu	37	7	92404042	92404042	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:92404042G>T	ENST00000265734.4	-	3	748	c.337C>A	c.(337-339)Cca>Aca	p.P113T	CDK6_ENST00000424848.2_Missense_Mutation_p.P113T	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	113	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity	p.P113T(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CCAGGCTCTGGAACTTTATCC	0.408000			T	MLLT10	ALL								20	170					2.21704e-12	3.08693e-12	0.002780	1	0
HTR5A	3361	broad.mit.edu	37	7	154862900	154862900	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:154862900C>A	ENST00000287907.2	+	1	867	c.291C>A	c.(289-291)agC>agA	p.S97R	AC093726.4_ENST00000395731.2_Missense_Mutation_p.R38S|AC093726.4_ENST00000543018.1_Missense_Mutation_p.R38S|AC093726.4_ENST00000493904.1_5'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	97						integral to plasma membrane	serotonin receptor activity	p.S97R(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGCCGCTGAGCCTGGTGCACG	0.672000													5	63					1.23904e-05	1.43571e-05	0.000602	1	0
KLHL31	401265	broad.mit.edu	37	6	53516934	53516934	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:53516934C>A	ENST00000370905.3	-	3	1507	c.1367G>T	c.(1366-1368)cGc>cTc	p.R456L	KLHL31_ENST00000407079.1_Missense_Mutation_p.R456L	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent			p.R456L(1)		autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					GTGGCAGCAGCGCGCCACCTC	0.711000													11	4					1.26454e-06	1.50977e-06	0.005443	1	0
NOS2	4843	broad.mit.edu	37	17	26093575	26093575	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:26093575C>A	ENST00000313735.6	-	19	2440	c.2207G>T	c.(2206-2208)aGg>aTg	p.R736M		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	736	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding	p.R736M(1)		autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGATTTGAGCCTCATGGTGAA	0.493000													70	208					6.58394e-13	9.31965e-13	0.014410	1	0
MC2R	4158	broad.mit.edu	37	18	13885062	13885062	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:13885062C>T	ENST00000327606.3	-	2	636	c.456G>A	c.(454-456)acG>acA	p.T152T		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	152					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding	p.T152T(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	TCCAGATGACCGTAAGCACCA	0.582000													13	60					0	0	0.001855	0	0
MGRN1	23295	broad.mit.edu	37	16	4731568	4731568	+	Silent	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:4731568A>C	ENST00000399577.5	+	13	1242	c.1149A>C	c.(1147-1149)ccA>ccC	p.P383P	MGRN1_ENST00000415496.1_Silent_p.P362P|MGRN1_ENST00000262370.7_Silent_p.P383P|MGRN1_ENST00000586183.1_Silent_p.P361P|MGRN1_ENST00000588994.1_Silent_p.P361P	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	383					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P383P(2)		endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						ACAGCGTCCCACCTGGCTACG	0.637000													28	43					0	0	0.012213	0	0
LAT2	7462	broad.mit.edu	37	7	73636006	73636006	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:73636006C>G	ENST00000460943.1	+	10	1261	c.372C>G	c.(370-372)ttC>ttG	p.F124L	LAT2_ENST00000344995.5_Missense_Mutation_p.F124L|LAT2_ENST00000398475.1_Missense_Mutation_p.F124L|LAT2_ENST00000275635.7_Missense_Mutation_p.F124L	NM_032464.2	NP_115853.2	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family, member 2	124					B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding	p.F124F(1)|p.F124L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6						GGGGGCGGTTCTCGAAGCCCC	0.587000													57	385					0	0	0.014410	0	0
ACOXL	55289	broad.mit.edu	37	2	111542323	111542323	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:111542323G>T	ENST00000389811.4	+	3	314	c.90G>T	c.(88-90)aaG>aaT	p.K30N	ACOXL_ENST00000340561.4_Missense_Mutation_p.K30N|ACOXL_ENST00000439055.1_Missense_Mutation_p.K30N			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	30					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity	p.K30N(2)		kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						AGAAAACAAAGAATTTTGTCA	0.438000													17	90					7.45023e-12	1.01793e-11	0.010504	1	0
MAN2C1	4123	broad.mit.edu	37	15	75648297	75648297	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:75648297G>A	ENST00000565683.1	-	26	3135	c.3124C>T	c.(3124-3126)Ccc>Tcc	p.P1042S	MAN2C1_ENST00000569482.1_Missense_Mutation_p.P1002S|MAN2C1_ENST00000267978.5_Missense_Mutation_p.P1025S|MAN2C1_ENST00000563622.1_Missense_Mutation_p.P926S	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	1025					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding	p.P1025S(1)		central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						ACTTGGAAGGGAGAAAAGGTG	0.582000													13	31					0	0	0.002450	0	0
VCAN	1462	broad.mit.edu	37	5	82833774	82833774	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:82833774C>A	ENST00000265077.3	+	8	5517	c.4952C>A	c.(4951-4953)aCa>aAa	p.T1651K	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.T664K|VCAN_ENST00000512590.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1651	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.T1651K(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GATGAAGATACAATGTTCACC	0.398000													29	38					1.13719e-10	1.49001e-10	0.008361	1	0
CNGA4	1262	broad.mit.edu	37	11	6261575	6261575	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:6261575G>T	ENST00000379936.2	+	4	666	c.551G>T	c.(550-552)aGc>aTc	p.S184I	CNGA4_ENST00000533426.1_Intron	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	184					response to stimulus|sensory perception of smell		cAMP binding	p.S184I(1)		endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTGGAACAGCTGCCTATAC	0.592000													74	62					1.07363e-35	1.95937e-35	0.014410	1	0
ADAMTS19	171019	broad.mit.edu	37	5	129019893	129019893	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:129019893C>A	ENST00000274487.4	+	18	2872	c.2727C>A	c.(2725-2727)agC>agA	p.S909R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	909	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.S909R(1)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAAACCAGAGCTCTAAAGCAC	0.423000													55	88					2.08403e-16	3.19801e-16	0.014410	1	0
CD226	10666	broad.mit.edu	37	18	67534622	67534622	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:67534622G>C	ENST00000280200.4	-	6	1124	c.856C>G	c.(856-858)Cta>Gta	p.L286V	CD226_ENST00000577287.1_Missense_Mutation_p.L131V|CD226_ENST00000581982.1_Missense_Mutation_p.L131V|CD226_ENST00000582621.1_Missense_Mutation_p.L286V	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	286					cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity	p.L286V(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				TCTGTAAATAGATCTCTTCTC	0.333000													26	162					0	0	0.006320	0	0
MGRN1	23295	broad.mit.edu	37	16	4727537	4727537	+	Silent	SNP	C	C	G	rs148776960	by1000genomes	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:4727537C>G	ENST00000399577.5	+	11	1122	c.1029C>G	c.(1027-1029)ccC>ccG	p.P343P	MGRN1_ENST00000415496.1_Silent_p.P344P|MGRN1_ENST00000262370.7_Silent_p.P343P|MGRN1_ENST00000586183.1_Silent_p.P343P|MGRN1_ENST00000588994.1_Silent_p.P343P	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	343					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P343P(2)		endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CCTTCAGCCCCGTCCTGGCCC	0.682000													9	60					0	0	0.006214	0	0
ABCA13	154664	broad.mit.edu	37	7	48311611	48311611	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:48311611G>C	ENST00000435803.1	+	17	2372	c.2348G>C	c.(2347-2349)aGa>aCa	p.R783T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	783					transport	integral to membrane	ATP binding|ATPase activity	p.R728T(1)|p.R783T(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AGTTTAAAGAGAGACCCATCT	0.428000													12	17					0	0	0.001855	0	0
PTGFR	5737	broad.mit.edu	37	1	78959227	78959227	+	Splice_Site	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:78959227G>T	ENST00000370756.3	+	2	1035		c.e2+1		PTGFR_ENST00000370757.3_Splice_Site|PTGFR_ENST00000370758.1_Splice_Site	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)						parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity	p.?(2)		breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CCCATTTCTGGTAAGAGCCTG	0.418000													5	43					0.00116845	0.00127308	0.001168	1	0
PCDHA4	56144	broad.mit.edu	37	5	140187200	140187200	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:140187200C>A	ENST00000530339.1	+	1	428	c.428C>A	c.(427-429)gCg>gAg	p.A143E	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.A143E|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.A143E	NM_018907.2	NP_061730.1												p.A143E(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTCCATCGCGGAATCCAGG	0.562000													23	116					7.92952e-12	1.07766e-11	0.003954	1	0
POTEG	404785	broad.mit.edu	37	14	19553590	19553590	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:19553590G>C	ENST00000409832.3	+	1	226	c.174G>C	c.(172-174)agG>agC	p.R58S		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	58								p.R58S(2)		cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						AGACACTCAGGAGCAAGATGG	0.612000													30	445					0	0	0.010771	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926439	106926439	+	RNA	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:106926439C>A	ENST00000434710.1	-	0	182																											CTCAGGGACCCCCCAGGCTGT	0.577000													7	154					0.000157383	0.000177534	0.003080	1	0
EYA1	2138	broad.mit.edu	37	8	72182002	72182002	+	Silent	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:72182002A>C	ENST00000340726.3	-	11	1662	c.1023T>G	c.(1021-1023)acT>acG	p.T341T	EYA1_ENST00000419131.1_Silent_p.T336T|EYA1_ENST00000388740.3_Silent_p.T308T|EYA1_ENST00000388742.4_Silent_p.T341T|EYA1_ENST00000388743.2_Silent_p.T340T|EYA1_ENST00000388741.2_Silent_p.T307T|EYA1_ENST00000303824.7_Silent_p.T335T	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	341					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.T341T(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CGTAGGACCCAGTAAGCAAGG	0.403000													21	38					0	0	0.004656	0	0
IQGAP2	10788	broad.mit.edu	37	5	75902107	75902107	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:75902107C>T	ENST00000274364.6	+	12	1633	c.1336C>T	c.(1336-1338)Caa>Taa	p.Q446*	IQGAP2_ENST00000379730.3_Nonsense_Mutation_p.Q5*	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	446					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity	p.Q446*(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GGTTAATGCTCAAATTCAAGA	0.358000													5	47					0	0	0.001168	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159781811	159781811	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:159781811C>G	ENST00000393975.3	-	2	346	c.343G>C	c.(343-345)Gga>Cga	p.G115R		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	70	Collagen-like.					collagen		p.G115R(1)		breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGTCGTGTCCATCTTGGCCG	0.677000													8	18					0	0	0.010729	0	0
MXRA5	25878	broad.mit.edu	37	X	3241311	3241311	+	Silent	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:3241311A>T	ENST00000217939.6	-	5	2569	c.2415T>A	c.(2413-2415)atT>atA	p.I805I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	805						extracellular region		p.I805I(2)		NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGTGGTTTTAATCAATGGGG	0.483000													17	112					0	0	0.014410	0	0
ANK2	287	broad.mit.edu	37	4	114279144	114279144	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:114279144T>A	ENST00000357077.4	+	38	9423	c.9370T>A	c.(9370-9372)Tat>Aat	p.Y3124N	ANK2_ENST00000264366.6_Missense_Mutation_p.Y3091N|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3091					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.Y3124N(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAAAGGTCCTATGCAGATGA	0.448000													25	52					0	0	0.006320	0	0
SPG11	80208	broad.mit.edu	37	15	44876526	44876526	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:44876526G>A	ENST00000261866.7	-	30	5368	c.5352C>T	c.(5350-5352)gcC>gcT	p.A1784A	SPG11_ENST00000427534.2_Silent_p.A1784A|SPG11_ENST00000535302.2_Silent_p.A1784A|SPG11_ENST00000558319.1_Silent_p.A1784A	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1784					cell death	cytosol|integral to membrane|nucleus	protein binding	p.A1784A(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CGTCCTCCTGGGCAAGCCAGT	0.582000													7	16					0	0	0.013537	0	0
IKBKE	9641	broad.mit.edu	37	1	206666678	206666678	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:206666678A>C	ENST00000367120.3	+	20	2385	c.2012A>C	c.(2011-2013)tAc>tCc	p.Y671S	IKBKE_ENST00000537984.1_Missense_Mutation_p.Y586S|C1orf147_ENST00000367119.1_Intron|IKBKE_ENST00000462698.1_3'UTR	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	671					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding	p.Y671S(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					ATAGCTCCTTACCCCAGCCCT	0.582000													22	138					0	0	0.007291	0	0
OR51V1	283111	broad.mit.edu	37	11	5221019	5221019	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:5221019C>A	ENST00000321255.1	-	1	911	c.912G>T	c.(910-912)aaG>aaT	p.K304N		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K304N(1)		endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGTTGGGTCTTGACACTGT	0.408000													28	29					3.99451e-17	6.18544e-17	0.009535	1	0
ABCB4	5244	broad.mit.edu	37	7	87031578	87031578	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:87031578G>T	ENST00000265723.4	-	28	3806	c.3695C>A	c.(3694-3696)aCc>aAc	p.T1232N	ABCB4_ENST00000359206.3_Missense_Mutation_p.T1225N|ABCB4_ENST00000453593.1_Missense_Mutation_p.T1178N|ABCB4_ENST00000358400.3_Missense_Mutation_p.T1178N|ABCB4_ENST00000545634.1_Missense_Mutation_p.T1225N	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1232	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.T1225N(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CACAATGCAGGTGCGGCCTTC	0.453000													12	137					0.000978159	0.00107262	0.010729	1	0
CASR	846	broad.mit.edu	37	3	122003461	122003461	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:122003461C>G	ENST00000498619.1	+	7	3128	c.2690C>G	c.(2689-2691)gCc>gGc	p.A897G	CASR_ENST00000490131.1_Missense_Mutation_p.A887G|CASR_ENST00000296154.5_Missense_Mutation_p.A887G	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	887	Interaction with RNF19A.				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity	p.A887G(1)|p.A887V(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCTGCCCGGGCCACGCTGCGC	0.617000													10	32					0	0	0.010729	0	0
SACS	26278	broad.mit.edu	37	13	23907731	23907731	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:23907731T>A	ENST00000382298.3	-	10	10872	c.10284A>T	c.(10282-10284)acA>acT	p.T3428T	SACS_ENST00000382292.3_Silent_p.T3428T|SACS_ENST00000402364.1_Silent_p.T2678T	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3428					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding	p.T3428T(1)|p.T3281T(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GTACGTAGCATGTTCCAAATT	0.358000													10	132					0	0	0.008291	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174210776	174210776	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:174210776C>G	ENST00000251507.4	+	5	872	c.698C>G	c.(697-699)tCc>tGc	p.S233C	RABGAP1L_ENST00000357444.6_Missense_Mutation_p.S196C|RABGAP1L_ENST00000367689.3_5'UTR	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	233	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity	p.S233C(1)		NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						CATGTTTTCTCCTGTGAAATT	0.348000													5	65					0	0	0.001168	0	0
TBC1D16	125058	broad.mit.edu	37	17	77921563	77921563	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:77921563C>A	ENST00000310924.2	-	9	1724	c.1609G>T	c.(1609-1611)Gtg>Ttg	p.V537L	TBC1D16_ENST00000340848.7_Missense_Mutation_p.V175L|TBC1D16_ENST00000570373.1_Missense_Mutation_p.V176L|TBC1D16_ENST00000576768.1_Missense_Mutation_p.V162L|TBC1D16_ENST00000572862.1_Missense_Mutation_p.V175L	NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	537	Rab-GAP TBC.					intracellular	Rab GTPase activator activity	p.V537L(1)		NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			ATGGGCGCCACCAGGTCCGAC	0.607000													28	58					1.75199e-13	2.53616e-13	0.007291	1	0
SNRNP200	23020	broad.mit.edu	37	2	96953686	96953686	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:96953686C>T	ENST00000323853.5	-	25	3357	c.3280G>A	c.(3280-3282)Gcg>Acg	p.A1094T	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1094	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.A1094T(1)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TCAAATATCGCTCGCATCAAC	0.507000													10	77					0	0	0.013537	0	0
IPO5	3843	broad.mit.edu	37	13	98641334	98641334	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:98641334A>T	ENST00000261574.5	+	7	617	c.437A>T	c.(436-438)cAg>cTg	p.Q146L	IPO5_ENST00000490680.1_Missense_Mutation_p.Q128L|IPO5_ENST00000539640.1_Intron	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	128					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding	p.Q146L(1)		breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GGCAATAACCAGTGGCCCGAA	0.388000													4	36					0	0	0.000602	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120348166	120348166	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:120348166G>A	ENST00000397843.2	+	36	3629	c.3463G>A	c.(3463-3465)Gat>Aat	p.D1155N	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.D1136N|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.D1052N	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1155					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.D1155N(1)		NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AGGAGATAATGATGAAGAAGA	0.343000			T	MLL	AML								5	51					0	0	0.001168	0	0
TRIM16	10626	broad.mit.edu	37	17	15539485	15539485	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:15539485C>A	ENST00000455584.2	-	3	757	c.714G>T	c.(712-714)gaG>gaT	p.E238D	TRIM16_ENST00000416464.2_Missense_Mutation_p.E108D|TRIM16_ENST00000336708.7_Missense_Mutation_p.E238D|TRIM16_ENST00000579219.1_Missense_Mutation_p.E22D|TRIM16_ENST00000577886.1_Missense_Mutation_p.E22D|TRIM16_ENST00000578237.1_Missense_Mutation_p.E238D														p.E238D(1)									GCTCCTTCTCCTCTAAGAAGA	0.572000													12	107					4.36969e-10	5.61033e-10	0.001855	1	0
BRWD3	254065	broad.mit.edu	37	X	79945592	79945592	+	Splice_Site	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:79945592C>A	ENST00000373275.4	-	32	3819		c.e32-1		BRWD3_ENST00000473691.1_Splice_Site	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3									p.?(1)		breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TGATATTCTCCTGTGAAAGAA	0.328000													6	27					3.59834e-05	4.15068e-05	0.001168	1	0
TEX14	56155	broad.mit.edu	37	17	56642232	56642232	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:56642232C>G	ENST00000389934.3	-	29	4299	c.4182G>C	c.(4180-4182)gaG>gaC	p.E1394D	TEX14_ENST00000240361.8_Missense_Mutation_p.E1400D|TEX14_ENST00000349033.5_Missense_Mutation_p.E1354D	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1400						cytoplasm	ATP binding|protein kinase activity	p.E1354D(1)|p.E1400D(1)		breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTGTTACCTCTCTGTGTCCT	0.318000													11	126					0	0	0.008291	0	0
ATP8B2	57198	broad.mit.edu	37	1	154319197	154319197	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:154319197G>T	ENST00000368489.3	+	26	3225	c.3225G>T	c.(3223-3225)ggG>ggT	p.G1075G		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	1061					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.G1075G(1)	IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAGCAATGGGCTCTTCGACA	0.537000													40	187					1.07121e-22	1.76576e-22	0.006999	1	0
TBL1XR1	79718	broad.mit.edu	37	3	176771667	176771667	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:176771667T>C	ENST00000430069.1	-	4	357	c.98A>G	c.(97-99)cAt>cGt	p.H33R	TBL1XR1_ENST00000457928.2_Missense_Mutation_p.H33R			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	33	LisH.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding	p.H33R(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			CTGACTGATATGGCTTTCTAT	0.378000													23	64					0	0	0.004656	0	0
SOX6	55553	broad.mit.edu	37	11	16071447	16071447	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:16071447C>G	ENST00000352083.6	-	11	1366	c.1289G>C	c.(1288-1290)cGa>cCa	p.R430P	SOX6_ENST00000527619.1_Missense_Mutation_p.R392P|SOX6_ENST00000316399.6_Missense_Mutation_p.R430P|SOX6_ENST00000528252.1_Missense_Mutation_p.R389P|SOX6_ENST00000528429.1_Missense_Mutation_p.R430P|SOX6_ENST00000396356.3_Missense_Mutation_p.R430P			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	430					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity	p.R430P(1)|p.R430Q(1)|p.R392P(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						TGTCTTGGGTCGGGATGAGAG	0.458000													28	212					0	0	0.004878	0	0
PARD3B	117583	broad.mit.edu	37	2	206480499	206480499	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:206480499G>T	ENST00000406610.2	+	23	3787	c.3580G>T	c.(3580-3582)Gat>Tat	p.D1194Y	PARD3B_ENST00000351153.1_Missense_Mutation_p.D1125Y|PARD3B_ENST00000349953.3_Missense_Mutation_p.D1093Y|PARD3B_ENST00000358768.2_Missense_Mutation_p.D1132Y|PARD3B_ENST00000488622.1_3'UTR	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1194					cell cycle|cell division	endomembrane system|tight junction		p.Q1131_D1132>HY(1)|p.Q1132_D1133>HY(1)|p.Q1124_D1125>HY(1)		breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCGAACCCAGGATTCCCGGCA	0.607000													40	72					6.33695e-27	1.10518e-26	0.007835	1	0
FAM172A	83989	broad.mit.edu	37	5	93217245	93217245	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:93217245C>A	ENST00000395965.3	-	7	859	c.717G>T	c.(715-717)aaG>aaT	p.K239N	FAM172A_ENST00000509163.1_Missense_Mutation_p.K193N|FAM172A_ENST00000505869.1_Missense_Mutation_p.K129N|FAM172A_ENST00000509739.1_Missense_Mutation_p.K92N	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	239						endoplasmic reticulum|extracellular region		p.K239N(1)		endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						AATCACGTCGCTTCTTTGTTT	0.358000													27	52					7.01153e-11	9.28211e-11	0.007291	1	0
ZNF354C	30832	broad.mit.edu	37	5	178506304	178506304	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:178506304C>T	ENST00000315475.6	+	5	1177	c.871C>T	c.(871-873)Ctg>Ttg	p.L291L		NM_014594.1	NP_055409.1	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L291L(1)		endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|urinary_tract(3)	30	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TATCAAACATCTGAGAGTGCA	0.413000													38	133					0	0	0.005524	0	0
ZNF395	55893	broad.mit.edu	37	8	28206278	28206278	+	Silent	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:28206278C>G	ENST00000344423.5	-	10	1631	c.1500G>C	c.(1498-1500)acG>acC	p.T500T	ZNF395_ENST00000523095.1_Silent_p.T500T|ZNF395_ENST00000523202.1_Silent_p.T500T	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	500					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.T500T(1)		cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		ACCGGCAGGCCGTGCACCACT	0.617000													10	45					0	0	0.001855	0	0
CHM	1121	broad.mit.edu	37	X	85213885	85213885	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:85213885C>A	ENST00000357749.2	-	6	829	c.800G>T	c.(799-801)cGa>cTa	p.R267L	CHM_ENST00000537751.1_Missense_Mutation_p.R119L|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	267					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.R267L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TCGTCCTTCTCGAAATGCAAG	0.353000													15	105					1.15088e-07	1.40358e-07	0.004007	1	0
KIF4B	285643	broad.mit.edu	37	5	154395531	154395531	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:154395531G>T	ENST00000435029.4	+	1	2272	c.2112G>T	c.(2110-2112)acG>acT	p.T704T		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	704	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity	p.T704T(2)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GACGTAAAACGGAAGAGGCAG	0.463000													32	43					1.67305e-13	2.43569e-13	0.006230	1	0
PTPRR	5801	broad.mit.edu	37	12	71054797	71054797	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:71054797G>T	ENST00000283228.2	-	12	2141	c.1689C>A	c.(1687-1689)ccC>ccA	p.P563P	PTPRR_ENST00000342084.4_Silent_p.P451P|PTPRR_ENST00000378778.1_Silent_p.P357P|PTPRR_ENST00000440835.2_Silent_p.P318P|PTPRR_ENST00000549308.1_Silent_p.P318P|PTPRR_ENST00000537619.2_5'UTR	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	563	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity	p.P563P(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GCTGTAGGAGGGGCTGGGCAC	0.532000													13	7					0.000422831	0.000473831	0.004007	1	0
KDR	3791	broad.mit.edu	37	4	55981185	55981185	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:55981185G>T	ENST00000263923.4	-	5	809	c.514C>A	c.(514-516)Cct>Act	p.P172T		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	172	Ig-like C2-type 2.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.P172N(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTACCATCAGGAACAAATCTC	0.378000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			9	28					0.000673444	0.000740064	0.008291	1	0
ELL3	80237	broad.mit.edu	37	15	44066902	44066902	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:44066902T>C	ENST00000319359.3	-	7	1356	c.715A>G	c.(715-717)Agc>Ggc	p.S239G	RP11-296A16.1_ENST00000417761.2_3'UTR|ELL3_ENST00000497465.1_5'UTR	NM_025165.2	NP_079441.1	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	239					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex		p.S239G(1)		cervix(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)	13		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		TGTAGGGGGCTTGGCACTAAA	0.463000													45	151					0	0	0.011902	0	0
ZNF17	7565	broad.mit.edu	37	19	57931868	57931868	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:57931868G>A	ENST00000307658.7	+	4	1277	c.1014G>A	c.(1012-1014)ggG>ggA	p.G338G	ZNF17_ENST00000601808.1_Silent_p.G336G|AC004076.7_ENST00000597410.1_Intron			P17021	ZNF17_HUMAN	zinc finger protein 17	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G336G(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		ATGAATGTGGGAAATACTTTA	0.418000													4	71					0	0	0.009096	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562563	140562563	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:140562563G>T	ENST00000361016.2	+	1	1584	c.429G>T	c.(427-429)ccG>ccT	p.P143P		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		143	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.P143P(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAAAAATACCGGAAAACAGTC	0.388000													16	40					5.01169e-05	5.755e-05	0.004990	1	0
ABCC11	85320	broad.mit.edu	37	16	48231969	48231969	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:48231969G>T	ENST00000394747.1	-	16	2576	c.2227C>A	c.(2227-2229)Cag>Aag	p.Q743K	ABCC11_ENST00000537808.1_Intron|ABCC11_ENST00000353782.5_Missense_Mutation_p.Q743K|ABCC11_ENST00000356608.2_Missense_Mutation_p.Q743K|ABCC11_ENST00000394748.1_Missense_Mutation_p.Q743K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	743						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.Q743K(1)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCTGTGTCCTGCAACATGTCC	0.572000													37	65					9.85913e-13	1.38788e-12	0.009718	1	0
IGSF9B	22997	broad.mit.edu	37	11	133789800	133789800	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:133789800C>A	ENST00000321016.8	-	18	4050	c.3820G>T	c.(3820-3822)Ggc>Tgc	p.G1274C	IGSF9B_ENST00000533871.2_Missense_Mutation_p.G1274C			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1274	Pro-rich.					integral to membrane|plasma membrane		p.G1274C(1)|p.G730C(1)		breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTGGTGAAGCCCATGGCGGGC	0.692000													10	20					0.00136819	0.00148755	0.013537	1	0
RAD9A	5883	broad.mit.edu	37	11	67159667	67159667	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:67159667G>T	ENST00000307980.2	+	2	163	c.70G>T	c.(70-72)Ggg>Tgg	p.G24W		NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	24					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding	p.G24W(1)		lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GTCCCGCATCGGGGACGAGCT	0.706000								Other conserved DNA damage response genes					9	20					2.80697e-09	3.55041e-09	0.010729	1	0
NPHP4	261734	broad.mit.edu	37	1	5964716	5964716	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:5964716T>C	ENST00000378156.4	-	16	2369	c.2104A>G	c.(2104-2106)Atc>Gtc	p.I702V	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	702					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity	p.I702V(1)		NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GGCACGAGGATGTGGGTCAGG	0.577000													8	41					0	0	0.010729	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053860	95053860	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:95053860G>T	ENST00000329597.7	+	3	371	c.161G>T	c.(160-162)aGg>aTg	p.R54M	SERPINA5_ENST00000553780.1_Missense_Mutation_p.R54M|SERPINA5_ENST00000554866.1_Missense_Mutation_p.R54M|SERPINA5_ENST00000554276.1_Missense_Mutation_p.R54M	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	54					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity	p.R54I(1)		endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GACCTCTACAGGGCCTTGGCT	0.627000													12	38					4.14922e-12	5.71496e-12	0.004007	1	0
FOLH1	2346	broad.mit.edu	37	11	49204738	49204738	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:49204738G>T	ENST00000340334.7	-	8	1206	c.838C>A	c.(838-840)Cat>Aat	p.H280N	FOLH1_ENST00000356696.3_Missense_Mutation_p.H295N|FOLH1_ENST00000256999.2_Missense_Mutation_p.H295N|FOLH1_ENST00000533034.1_Missense_Mutation_p.H280N|FOLH1_ENST00000343844.4_5'UTR	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	295	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity	p.H295N(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CCAATTGGATGAACAGGAATA	0.358000													34	64					1.57351e-24	2.67132e-24	0.003755	1	0
RIMS2	9699	broad.mit.edu	37	8	105001603	105001603	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:105001603G>T	ENST00000507740.1	+	14	2610	c.2374G>T	c.(2374-2376)Gac>Tac	p.D792Y	RIMS2_ENST00000436393.2_Missense_Mutation_p.D778Y|RIMS2_ENST00000262231.10_Missense_Mutation_p.D839Y|RIMS2_ENST00000406091.3_Missense_Mutation_p.D1000Y	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1062					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.D792Y(2)|p.D1067Y(1)|p.D1000Y(1)|p.D778Y(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TAGCCGAATGGACAGACATCG	0.368000										HNSCC(12;0.0054)			16	127					1.22574e-08	1.52769e-08	0.014323	1	0
CPS1	1373	broad.mit.edu	37	2	211525369	211525369	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:211525369T>C	ENST00000233072.5	+	32	4113	c.3917T>C	c.(3916-3918)gTt>gCt	p.V1306A	CPS1_ENST00000430249.2_Missense_Mutation_p.V1312A|CPS1_ENST00000451903.2_Missense_Mutation_p.V855A	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1306					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.V1312A(1)|p.V1306A(1)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GCTGACTATGTTGCAATTAAG	0.318000													22	75					0	0	0.003954	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455381	84455381	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:84455381G>T	ENST00000377084.2	-	1	1147	c.262C>A	c.(262-264)Cac>Aac	p.H88N		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	88						integral to membrane		p.H88N(1)		NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTTTCCATGTGCAAACTAACC	0.448000													26	48					1.45844e-13	2.13542e-13	0.013726	1	0
SLC12A1	6557	broad.mit.edu	37	15	48524927	48524927	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:48524927C>A	ENST00000396577.3	+	8	1194	c.979C>A	c.(979-981)Caa>Aaa	p.Q327K	SLC12A1_ENST00000558405.1_Missense_Mutation_p.Q327K|SLC12A1_ENST00000559723.1_3'UTR|SLC12A1_ENST00000330289.6_Missense_Mutation_p.Q327K|SLC12A1_ENST00000380993.3_Missense_Mutation_p.Q327K	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	327					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity	p.Q327K(2)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATTCCAGGCCCAAGTCATTCT	0.338000													41	51					8.16277e-20	1.30758e-19	0.006999	1	0
ADH1B	125	broad.mit.edu	37	4	100232725	100232725	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:100232725G>T	ENST00000305046.8	-	7	984	c.917C>A	c.(916-918)cCt>cAt	p.P306H	ADH1B_ENST00000394887.3_Missense_Mutation_p.P266H			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	306					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding	p.P306H(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TAGCAGCATAGGGTTTATTGA	0.468000													26	134					1.74807e-11	2.33839e-11	0.010818	1	0
RANBP17	64901	broad.mit.edu	37	5	170305133	170305133	+	Silent	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:170305133T>C	ENST00000523189.1	+	2	215	c.51T>C	c.(49-51)caT>caC	p.H17H		NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	17					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity	p.H17H(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TATGTACTCATCTCTACATAG	0.323000			T	TRD@	ALL								9	33					0	0	0.004482	0	0
FSTL5	56884	broad.mit.edu	37	4	162697067	162697067	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:162697067T>A	ENST00000306100.5	-	5	1005	c.569A>T	c.(568-570)gAc>gTc	p.D190V	FSTL5_ENST00000379164.4_Missense_Mutation_p.D189V|FSTL5_ENST00000536695.1_Missense_Mutation_p.D189V|FSTL5_ENST00000427802.2_Missense_Mutation_p.D189V	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	190	EF-hand 1.					extracellular region	calcium ion binding	p.D190V(1)		central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCCATTACTGTCTGCATCAAA	0.289000													4	54					0	0	0.000602	0	0
OR5B3	441608	broad.mit.edu	37	11	58170869	58170869	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:58170869G>A	ENST00000309403.2	-	1	13	c.14C>T	c.(13-15)aCa>aTa	p.T5I		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T5I(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGTTACTTCTGTCTTATTTTC	0.358000													31	114					0	0	0.008361	0	0
LRP1B	53353	broad.mit.edu	37	2	141004719	141004719	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:141004719G>A	ENST00000389484.3	-	87	14231	c.13260C>T	c.(13258-13260)aaC>aaT	p.N4420N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4420	EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.N4420N(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGCCTGACCAGTTGGTGGAGC	0.393000										TSP Lung(27;0.18)			14	23					0	0	0.007413	0	0
HUWE1	10075	broad.mit.edu	37	X	53674396	53674396	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:53674396A>T	ENST00000342160.3	-	5	723	c.266T>A	c.(265-267)cTg>cAg	p.L89Q	HUWE1_ENST00000218328.8_Missense_Mutation_p.L89Q|HUWE1_ENST00000262854.6_Missense_Mutation_p.L89Q			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	89					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.L89Q(2)		NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AAGCATTTTCAGTTGCTCTCT	0.478000													18	71					0	0	0.006122	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558901	113558901	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:113558901C>A	ENST00000284601.3	-	1	219	c.151G>T	c.(151-153)Gac>Tac	p.D51Y		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	51					glycogen metabolic process	integral to membrane		p.D51Y(1)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AGGTATATGTCTTCAGAAGAA	0.393000													18	170					4.35082e-09	5.47603e-09	0.010504	1	0
SNHG14	104472715	broad.mit.edu	37	15	25458687	25458687	+	RNA	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:25458687C>T	ENST00000424208.1	+	0	2644				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						GCCCCTGGTGCACTGAAGCTC	0.607000													15	18					0	0	0.002450	0	0
DCAF4	26094	broad.mit.edu	37	14	73421133	73421133	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:73421133G>T	ENST00000553457.1	+	10	937	c.647G>T	c.(646-648)gGa>gTa	p.G216V	DCAF4_ENST00000353777.3_Intron|DCAF4_ENST00000358377.2_Missense_Mutation_p.G316V|DCAF4_ENST00000555042.1_Missense_Mutation_p.G317V|DCAF4_ENST00000509153.1_Missense_Mutation_p.G256V|DCAF4_ENST00000394234.2_Missense_Mutation_p.G216V			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	316						CUL4 RING ubiquitin ligase complex		p.G316V(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						GTGGTGACGGGACACCGGCAG	0.542000													9	68					1.12685e-05	1.30868e-05	0.004482	1	0
BRINP3	339479	broad.mit.edu	37	1	190067649	190067649	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:190067649C>A	ENST00000367462.3	-	8	2031	c.1800G>T	c.(1798-1800)aaG>aaT	p.K600N	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.K498N	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		600						extracellular region		p.K600N(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GTAGGTCCAACTTAGTCCGCT	0.468000													75	373					5.72124e-26	9.91035e-26	0.014410	1	0
KRT1	3848	broad.mit.edu	37	12	53073922	53073922	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:53073922C>T	ENST00000252244.3	-	1	269	c.211G>A	c.(211-213)Ggt>Agt	p.G71S		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	71	Gly/Phe/Ser-rich.|Head.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.G71S(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						TTACTGCCACCAAGGTTAACA	0.542000													10	7					0	0	0.002450	0	0
POTEM	641455	broad.mit.edu	37	14	20020047	20020047	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:20020047C>G	ENST00000551509.1	-	1	225	c.174G>C	c.(172-174)agG>agC	p.R58S		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	58								p.R58S(2)		endometrium(4)|kidney(1)|lung(4)	9						CCATCTTGCTCCTGAGTGTCT	0.612000													7	133					0	0	0.013537	0	0
DCHS2	54798	broad.mit.edu	37	4	155156682	155156682	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:155156682C>A	ENST00000357232.3	-	25	7756	c.7757G>T	c.(7756-7758)aGa>aTa	p.R2586I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2586					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R2586I(2)		NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCGGGTCACTCTCAAGTCCGC	0.428000													29	100					3.1745e-13	4.54389e-13	0.008361	1	0
TENM4	26011	broad.mit.edu	37	11	78412990	78412990	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:78412990C>T	ENST00000278550.7	-	28	5130	c.4668G>A	c.(4666-4668)ggG>ggA	p.G1556G		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4									p.G1556G(2)									TTCGGATGTTCCCAAGGTCGG	0.483000													41	84					0	0	0.011902	0	0
ATRX	546	broad.mit.edu	37	X	76920178	76920178	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:76920178T>C	ENST00000373344.5	-	11	4113	c.3899A>G	c.(3898-3900)aAa>aGa	p.K1300R	ATRX_ENST00000395603.3_Missense_Mutation_p.K1262R|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1300					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.K1300R(2)|p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AGTTCTTTTTTTCCCTTCTTC	0.373000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						70	83					0	0	0.014410	0	0
MXRA8	54587	broad.mit.edu	37	1	1289872	1289872	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:1289872C>T	ENST00000309212.6	-	6	997	c.967G>A	c.(967-969)Ggc>Agc	p.G323S	MXRA8_ENST00000342753.4_Missense_Mutation_p.G222S|MXRA8_ENST00000445648.2_Missense_Mutation_p.G323S	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	323						integral to membrane		p.G323S(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACGTTGTGGCCGCGCGCCAGT	0.692000													6	56					0	0	0.010729	0	0
PBXIP1	57326	broad.mit.edu	37	1	154918707	154918707	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:154918707C>T	ENST00000368463.3	-	10	1514	c.1443G>A	c.(1441-1443)ggG>ggA	p.G481G	PBXIP1_ENST00000542459.1_Silent_p.G326G|PBXIP1_ENST00000539880.1_Silent_p.G308G|PBXIP1_ENST00000368465.1_Silent_p.G452G	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	481					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity	p.G481G(1)		breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGTCTCTCTGCCCATCCCACC	0.562000													92	499					0	0	0.014410	0	0
IDUA	3425	broad.mit.edu	37	4	994668	994668	+	Splice_Site	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:994668A>C	ENST00000453894.1	+	3	332		c.e3-1		IDUA_ENST00000247933.4_Splice_Site|IDUA_ENST00000514224.1_Splice_Site			P35475	IDUA_HUMAN	iduronidase, alpha-L-						disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity	p.?(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	CCTGTGTTCCAGGGTTTGAGC	0.622000													10	53					0	0	0.001855	0	0
RYR3	6263	broad.mit.edu	37	15	33926924	33926924	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:33926924C>A	ENST00000389232.4	+	25	3235	c.3165C>A	c.(3163-3165)gaC>gaA	p.D1055E	RYR3_ENST00000415757.3_Missense_Mutation_p.D1055E	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1055	4 X approximate repeats.|B30.2/SPRY 2.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.D1055E(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGCCATCAGACCAAGAACTAG	0.453000													31	53					4.65686e-17	7.1893e-17	0.003755	1	0
CASP2	835	broad.mit.edu	37	7	142985564	142985564	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:142985564G>T	ENST00000310447.5	+	1	257	c.16G>T	c.(16-18)Gcg>Tcg	p.A6S	CASP2_ENST00000392925.2_Missense_Mutation_p.A6S	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	6					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding	p.A6S(1)		endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					GGCGCCGAGCGCGGGGTCTTG	0.672000													32	19					1.45844e-13	2.13542e-13	0.013726	1	0
ZNF761	388561	broad.mit.edu	37	19	53957975	53957975	+	RNA	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:53957975G>T	ENST00000454407.1	+	0	667							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G18W(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GTTCCATGCAGGGACATTGCA	0.383000													31	45					4.02929e-09	5.08387e-09	0.010818	1	0
KRT85	3891	broad.mit.edu	37	12	52760934	52760934	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:52760934C>A	ENST00000257901.3	-	1	331	c.256G>T	c.(256-258)Ggc>Tgc	p.G86C		NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	86	Head.				epidermis development	keratin filament	protein binding|structural molecule activity	p.G86C(1)		NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CCGCACACGCCCCCGGAGCGG	0.687000													29	26					7.53189e-24	1.25778e-23	0.007835	1	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858837	149858837	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:149858837C>G	ENST00000331380.2	+	1	313	c.313C>G	c.(313-315)Cag>Gag	p.Q105E		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	105					nucleosome assembly	nucleosome|nucleus	DNA binding	p.Q105E(1)		NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CACCATCGCCCAGGGCGGCGT	0.527000													25	130					0	0	0.006320	0	0
AP3S1	1176	broad.mit.edu	37	5	115249134	115249134	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:115249134A>G	ENST00000316788.7	+	6	1086	c.529A>G	c.(529-531)Att>Gtt	p.I177V	AP3S1_ENST00000505423.1_3'UTR	NM_001284.2	NP_001275.1	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1 subunit	177					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity	p.I177V(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)	12		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		CCCAAGAAATATTAACATTGG	0.408000													10	139					0	0	0.001855	0	0
GFI1B	8328	broad.mit.edu	37	9	135865148	135865148	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:135865148G>T	ENST00000339463.3	+	10	1487	c.668G>T	c.(667-669)cGc>cTc	p.R223L	GFI1B_ENST00000372123.1_Missense_Mutation_p.R177L|GFI1B_ENST00000372124.1_Missense_Mutation_p.R177L|GFI1B_ENST00000534944.1_Missense_Mutation_p.R177L|GFI1B_ENST00000372122.1_Missense_Mutation_p.R223L|GFI1B_ENST00000450530.1_Missense_Mutation_p.R223L			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	223	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding	p.R223F(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TTCGAGTGCCGCATGTGCGGC	0.677000													16	15					1.01871e-10	1.34165e-10	0.008871	1	0
PLOD3	8985	broad.mit.edu	37	7	100853847	100853847	+	Missense_Mutation	SNP	G	G	A	rs145508748	byFrequency	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:100853847G>A	ENST00000223127.3	-	13	1864	c.1466C>T	c.(1465-1467)cCg>cTg	p.P489L		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	489					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding	p.P489L(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	GGCCATGTCCGGGTCTGTGTC	0.612000													10	85					0	0	0.008291	0	0
OR10G2	26534	broad.mit.edu	37	14	22102444	22102444	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:22102444G>A	ENST00000542433.1	-	1	652	c.555C>T	c.(553-555)gaC>gaT	p.D185D		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D185D(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CTGCGCGGATGTCACAGATAA	0.552000													19	90					0	0	0.004656	0	0
RYR2	6262	broad.mit.edu	37	1	237813270	237813270	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:237813270G>T	ENST00000366574.2	+	50	7923	c.7606G>T	c.(7606-7608)Gct>Tct	p.A2536S	RYR2_ENST00000360064.6_Missense_Mutation_p.A2534S|RYR2_ENST00000542537.1_Missense_Mutation_p.A2520S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2536	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.A2534S(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCTCTCTTTGCTGGCACAGA	0.478000													25	161					7.92952e-12	1.07766e-11	0.003954	1	0
SLC15A3	51296	broad.mit.edu	37	11	60711180	60711180	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:60711180T>C	ENST00000227880.3	-	3	1210	c.977A>G	c.(976-978)tAc>tGc	p.Y326C		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	326					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity	p.Y326C(1)		central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GACCATCCAGTAGGGCACCAG	0.592000													14	26					0	0	0.004007	0	0
PAPOLB	56903	broad.mit.edu	37	7	4900849	4900849	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:4900849C>A	ENST00000404991.1	-	1	776	c.590G>T	c.(589-591)tGc>tTc	p.C197F	RADIL_ENST00000399583.3_Intron|RADIL_ENST00000536091.1_Intron	NM_020144.4	NP_064529.4	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	197					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			kidney(1)|large_intestine(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		GCTTCTTATGCATCTAATGTC	0.368000													23	49					9.57634e-11	1.26447e-10	0.003330	1	0
CSNK1G3	1456	broad.mit.edu	37	5	122950054	122950054	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:122950054A>C	ENST00000395412.1	+	14	2051	c.1332A>C	c.(1330-1332)aaA>aaC	p.K444N	CSNK1G3_ENST00000521364.1_Missense_Mutation_p.K412N|CSNK1G3_ENST00000510842.2_Missense_Mutation_p.K413N|CSNK1G3_ENST00000512718.3_Missense_Mutation_p.K337N|CSNK1G3_ENST00000361991.2_Missense_Mutation_p.K436N|CSNK1G3_ENST00000511130.2_Missense_Mutation_p.K300N|CSNK1G3_ENST00000395411.1_Missense_Mutation_p.K436N|CSNK1G3_ENST00000360683.2_Missense_Mutation_p.K444N|CSNK1G3_ENST00000345990.4_Missense_Mutation_p.K412N	NM_001044723.1	NP_001038188.1	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3	436					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity	p.K436N(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(1)	15		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		GTTTTTTCAAACGAAGGAAAA	0.368000													20	37					0	0	0.012319	0	0
LMOD1	25802	broad.mit.edu	37	1	201868511	201868511	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:201868511G>T	ENST00000367288.4	-	2	1876	c.1630C>A	c.(1630-1632)Ccc>Acc	p.P544T	RP11-307B6.3_ENST00000414927.1_RNA|RP11-307B6.3_ENST00000458139.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	544					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding	p.P544T(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						ATGATAAGGGGTGGAGCCAAG	0.567000													7	27					0.000157383	0.000177534	0.003080	1	0
NPFFR2	10886	broad.mit.edu	37	4	73013093	73013093	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:73013093T>A	ENST00000308744.6	+	4	1231	c.1133T>A	c.(1132-1134)cTc>cAc	p.L378H	NPFFR2_ENST00000358749.3_Missense_Mutation_p.L276H|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000395999.1_Missense_Mutation_p.L279H	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	378					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity	p.L378H(1)		NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			ATTAAGATGCTCCTGATTGTG	0.502000													18	53					0	0	0.007413	0	0
OR52K1	390036	broad.mit.edu	37	11	4510855	4510855	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:4510855C>A	ENST00000307632.3	+	1	747	c.725C>A	c.(724-726)aCa>aAa	p.T242K		NM_001005171.2	NP_001005171.2	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K, member 1	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T242K(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(18)|skin(2)|stomach(1)	32		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCATTTGGGACATGTGTGTCT	0.542000													130	100					8.39346e-61	1.58854e-60	0.014410	1	0
TXLNG	55787	broad.mit.edu	37	X	16859727	16859727	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chrX:16859727T>A	ENST00000380122.5	+	10	1486	c.1425T>A	c.(1423-1425)ccT>ccA	p.P475P	TXLNG_ENST00000398155.4_Silent_p.P343P|TXLNG_ENST00000485153.1_3'UTR	NM_018360.2	NP_060830.2	Q9NUQ3	TXLNG_HUMAN	taxilin gamma	475					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane		p.P475P(1)		breast(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	15						TAGCAACACCTGTGATGCAGC	0.532000													14	45					0	0	0.001855	0	0
SERPINA3	12	broad.mit.edu	37	14	95088697	95088697	+	Missense_Mutation	SNP	C	C	G	rs144438452		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:95088697C>G	ENST00000553947.1	+	7	1900	c.1012C>G	c.(1012-1014)Ctg>Gtg	p.L338V	SERPINA3_ENST00000467132.1_Missense_Mutation_p.L313V|SERPINA3_ENST00000556388.1_3'UTR|SERPINA3_ENST00000482740.1_Missense_Mutation_p.L95V|SERPINA3_ENST00000393080.4_Missense_Mutation_p.L313V|SERPINA3_ENST00000393078.3_Missense_Mutation_p.L313V			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	313					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.L313V(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TGAGCTCTACCTGCCAAAGTT	0.498000													35	143					0	0	0.006999	0	0
LILRB1	10859	broad.mit.edu	37	19	55143080	55143080	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:55143080C>A	ENST00000396331.1	+	5	557	c.200C>A	c.(199-201)gCa>gAa	p.A67E	LILRB1_ENST00000396327.3_Missense_Mutation_p.A67E|LILRB1_ENST00000324602.7_Missense_Mutation_p.A67E|LILRB1_ENST00000396317.1_Missense_Mutation_p.A67E|LILRB1_ENST00000418536.2_Missense_Mutation_p.A67E|LILRB1_ENST00000448689.1_Missense_Mutation_p.A67E|LILRB1_ENST00000396321.2_Missense_Mutation_p.A67E|LILRB1_ENST00000434867.2_Missense_Mutation_p.A67E|LILRB1_ENST00000396332.4_Missense_Mutation_p.A67E|LILRB1_ENST00000396315.1_Missense_Mutation_p.A67E|LILRB1_ENST00000427581.2_Missense_Mutation_p.A103E	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	67	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.A67E(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		AAGAAAACAGCACTCTGGATT	0.552000										HNSCC(37;0.09)			50	60					4.78724e-31	8.52363e-31	0.014410	1	0
NEGR1	257194	broad.mit.edu	37	1	72400950	72400950	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:72400950C>A	ENST00000357731.4	-	2	460	c.221G>T	c.(220-222)cGg>cTg	p.R74L	NEGR1_ENST00000306821.3_5'UTR|NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Missense_Mutation_p.R72L	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	74	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane		p.R74L(1)		endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AATACTTGACCGGTTCAGCCA	0.383000													22	43					2.32416e-17	3.62087e-17	0.014323	1	0
LPA	4018	broad.mit.edu	37	6	161016486	161016486	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:161016486C>A	ENST00000447678.1	-	22	3489	c.3369G>T	c.(3367-3369)tgG>tgT	p.W1123C	LPA_ENST00000316300.5_Missense_Mutation_p.W1123C	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3631	Kringle 10.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity	p.W1123C(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGCAGTACTCCCACCTGACAC	0.507000													37	60					2.13384e-23	3.55176e-23	0.014410	1	0
ERICH1	157697	broad.mit.edu	37	8	618725	618725	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:618725C>A	ENST00000262109.7	-	5	1208	c.1131G>T	c.(1129-1131)gcG>gcT	p.A377A	ERICH1_ENST00000522706.1_Silent_p.A283A	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	377								p.A377A(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		TGCTGTGTGACGCAAGGCGGT	0.522000													26	46					2.24059e-21	3.65797e-21	0.006320	1	0
NPY5R	4889	broad.mit.edu	37	4	164271917	164271917	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:164271917G>T	ENST00000515560.1	+	4	2014	c.492G>T	c.(490-492)tgG>tgT	p.W164C	NPY5R_ENST00000506953.1_Missense_Mutation_p.W164C|NPY5R_ENST00000338566.3_Missense_Mutation_p.W164C			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	164					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane		p.W164C(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				CTACTGTCTGGACACTAGGTT	0.378000													54	240					5.73376e-24	9.60639e-24	0.014410	1	0
PSD2	84249	broad.mit.edu	37	5	139216501	139216501	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:139216501G>T	ENST00000274710.3	+	10	1714	c.1509G>T	c.(1507-1509)ctG>ctT	p.L503L		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	503					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity	p.L503L(1)		breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCCTTCCTGGATGTCCCAC	0.592000													90	144					3.29526e-42	6.12319e-42	0.014410	1	0
RIMS4	140730	broad.mit.edu	37	20	43384969	43384969	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:43384969G>A	ENST00000372851.3	-	6	682	c.616C>T	c.(616-618)Cgg>Tgg	p.R206W	RIMS4_ENST00000541604.2_Missense_Mutation_p.R207W	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	206	C2.				exocytosis|neurotransmitter transport	cell junction|synapse		p.R206W(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CGCTCCATCCGCCCGTAGTTC	0.627000													5	24					0	0	0.006214	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563649	140563649	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:140563649C>A	ENST00000361016.2	+	1	2670	c.1515C>A	c.(1513-1515)tcC>tcA	p.S505S		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		505	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.S505S(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGGTCTCCATCAACGCAG	0.687000													13	35					7.11191e-15	1.05645e-14	0.013726	1	0
MYLK	4638	broad.mit.edu	37	3	123458844	123458844	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:123458844A>T	ENST00000360772.3	-	7	756	c.378T>A	c.(376-378)agT>agA	p.S126R	MYLK_ENST00000360304.3_Missense_Mutation_p.S126R|MYLK_ENST00000359169.1_Missense_Mutation_p.S126R|MYLK_ENST00000346322.5_Missense_Mutation_p.S126R|MYLK_ENST00000475616.1_Missense_Mutation_p.S126R			Q15746	MYLK_HUMAN	myosin light chain kinase	126					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.S126R(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTTCGCAAAACTTCCTGCAA	0.463000													65	156					0	0	0.014410	0	0
CACNA1E	777	broad.mit.edu	37	1	181701768	181701768	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:181701768G>C	ENST00000526775.1	+	19	2654	c.2489G>C	c.(2488-2490)cGc>cCc	p.R830P	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R849P|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R849P|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R800P|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R456P|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R781P|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R830P	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	849					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.R849P(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAGGAGGAGCGCATCAGCCGT	0.677000													3	2					0	0	0.009096	0	0
BDP1	55814	broad.mit.edu	37	5	70808256	70808256	+	Splice_Site	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:70808256G>T	ENST00000358731.4	+	18	4510		c.e18+1		BDP1_ENST00000380675.2_Splice_Site	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB						regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.?(1)		NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTAATTTAAGGTACAAGTGTG	0.313000													16	48					6.94344e-10	8.84813e-10	0.006122	1	0
RAD51D	5892	broad.mit.edu	37	17	33434066	33434066	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:33434066G>T	ENST00000345365.6	-	5	676	c.421C>A	c.(421-423)Ctg>Atg	p.L141M	RAD51D_ENST00000590380.1_5'UTR|RAD51D_ENST00000590016.1_Missense_Mutation_p.L161M|RAD51L3-RFFL_ENST00000593039.1_Intron|RAD51D_ENST00000394589.4_Missense_Mutation_p.L141M|RAD51D_ENST00000335858.7_Intron|RAD51D_ENST00000360276.3_Intron|RAD51D_ENST00000460118.2_Missense_Mutation_p.L22M	NM_002878.3	NP_002869.3	O75771	RA51D_HUMAN	RAD51 paralog D	141					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding	p.L141M(1)|p.L161M(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						GAAGCTGTCAGCCCTCCATTG	0.542000								Direct reversal of damage					23	115					5.45024e-15	8.11975e-15	0.003330	1	0
FUT10	84750	broad.mit.edu	37	8	33246950	33246950	+	Missense_Mutation	SNP	C	C	T	rs149448636		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:33246950C>T	ENST00000327671.5	-	4	1374	c.743G>A	c.(742-744)cGa>cAa	p.R248Q	FUT10_ENST00000518076.1_5'UTR|FUT10_ENST00000518672.1_Missense_Mutation_p.R220Q|FUT10_ENST00000335589.3_Missense_Mutation_p.R186Q|FUT10_ENST00000524021.1_Missense_Mutation_p.R220Q	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	248					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity	p.R248Q(1)		cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		GTCTTTGTTTCGTAAACATTC	0.453000													9	135					0	0	0.010729	0	0
NOD2	64127	broad.mit.edu	37	16	50744658	50744658	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:50744658A>T	ENST00000300589.2	+	4	941	c.836A>T	c.(835-837)gAg>gTg	p.E279V	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	279					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding	p.E279V(1)		cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CTGGGCCTGGAGGAGCTCTTC	0.642000													12	22					0	0	0.002450	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045394	142045394	+	RNA	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:142045394T>A	ENST00000390392.3	+	0	143																											TGTGCGGTTCTCTGTCTCCTG	0.587000													75	244					0	0	0.014410	0	0
ZEB1	6935	broad.mit.edu	37	10	31809437	31809437	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:31809437C>A	ENST00000446923.2	+	7	1517	c.1126C>A	c.(1126-1128)Caa>Aaa	p.Q376K	ZEB1_ENST00000361642.5_Missense_Mutation_p.Q393K|ZEB1_ENST00000560721.2_Missense_Mutation_p.Q372K|ZEB1_ENST00000542815.3_Missense_Mutation_p.Q325K|ZEB1_ENST00000320985.10_Missense_Mutation_p.Q392K|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	392					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.Q392K(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GGGCATGGTGCAAGCTGTTGT	0.438000													14	60					1.3612e-06	1.61762e-06	0.003163	1	0
SERPINA5	5104	broad.mit.edu	37	14	95053861	95053861	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:95053861G>T	ENST00000329597.7	+	3	372	c.162G>T	c.(160-162)agG>agT	p.R54S	SERPINA5_ENST00000553780.1_Missense_Mutation_p.R54S|SERPINA5_ENST00000554866.1_Missense_Mutation_p.R54S|SERPINA5_ENST00000554276.1_Missense_Mutation_p.R54S	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	54					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity	p.R54I(1)		endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	ACCTCTACAGGGCCTTGGCTT	0.622000													12	38					4.14922e-12	5.71496e-12	0.004007	1	0
LATS2	26524	broad.mit.edu	37	13	21620119	21620119	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:21620119C>A	ENST00000382592.4	-	2	452	c.47G>T	c.(46-48)cGg>cTg	p.R16L	LATS2_ENST00000542899.1_Missense_Mutation_p.R16L	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	16					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.R16L(2)		breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CAGTCGCTGCCGGCTATTTCC	0.458000													31	71					6.70999e-13	9.47183e-13	0.004289	1	0
NLRP4	147945	broad.mit.edu	37	19	56373482	56373482	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:56373482T>A	ENST00000301295.6	+	5	2565	c.2143T>A	c.(2143-2145)Tgt>Agt	p.C715S	NLRP4_ENST00000587891.1_Missense_Mutation_p.C640S|NLRP4_ENST00000346986.5_Missense_Mutation_p.C715S	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	715							ATP binding	p.C715S(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CAGGTCCCTCTGTGATGCCTT	0.478000													55	50					0	0	0.014410	0	0
DAGLA	747	broad.mit.edu	37	11	61511535	61511535	+	Silent	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:61511535C>G	ENST00000257215.5	+	20	2819	c.2703C>G	c.(2701-2703)cgC>cgG	p.R901R		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	901					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity	p.R901R(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		ACAATGGGCGCCTGGGGGACT	0.667000													10	43					0	0	0.008291	0	0
NLRP2	55655	broad.mit.edu	37	19	55493644	55493644	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:55493644T>C	ENST00000543010.1	+	6	721	c.578T>C	c.(577-579)aTc>aCc	p.I193T	NLRP2_ENST00000538819.1_Missense_Mutation_p.I169T|NLRP2_ENST00000537859.1_Missense_Mutation_p.I171T|NLRP2_ENST00000263437.6_Missense_Mutation_p.I190T|NLRP2_ENST00000391721.4_Missense_Mutation_p.I169T|NLRP2_ENST00000427260.2_Missense_Mutation_p.I170T|NLRP2_ENST00000339757.7_Missense_Mutation_p.I171T|NLRP2_ENST00000448584.2_Missense_Mutation_p.I193T	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	193					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding	p.I193T(1)		large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AAGATGCTGATCCCATTCAGC	0.537000													91	121					0	0	0.014410	0	0
SYT4	6860	broad.mit.edu	37	18	40854041	40854041	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr18:40854041A>T	ENST00000255224.3	-	2	721	c.353T>A	c.(352-354)cTg>cAg	p.L118Q	SYT4_ENST00000590752.1_Missense_Mutation_p.L100Q|SYT4_ENST00000586678.1_Intron	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	118						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity	p.L118Q(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TGCATTCTCCAGATCAGAAGG	0.438000													18	87					0	0	0.008871	0	0
GABRB3	2562	broad.mit.edu	37	15	26806188	26806188	+	Missense_Mutation	SNP	T	T	G	rs149963014	by1000genomes	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:26806188T>G	ENST00000541819.2	-	9	1241	c.1139A>C	c.(1138-1140)tAt>tCt	p.Y380S	GABRB3_ENST00000545868.1_Missense_Mutation_p.Y239S|GABRB3_ENST00000299267.4_Missense_Mutation_p.Y324S|GABRB3_ENST00000311550.5_Missense_Mutation_p.Y324S|GABRB3_ENST00000400188.3_Missense_Mutation_p.Y253S			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	324					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.Y324S(2)|p.Y380S(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GACAAAGGCATACTCCAGAAG	0.483000													18	78					0	0	0.008871	0	0
NPY5R	4889	broad.mit.edu	37	4	164271576	164271576	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:164271576G>T	ENST00000515560.1	+	4	1673	c.151G>T	c.(151-153)Gta>Tta	p.V51L	NPY5R_ENST00000506953.1_Missense_Mutation_p.V51L|NPY5R_ENST00000338566.3_Missense_Mutation_p.V51L			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	51					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane		p.V51L(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				CTATACATTTGTAAGTCTTCT	0.393000													55	103					1.0442e-30	1.85273e-30	0.014410	1	0
EXOSC7	23016	broad.mit.edu	37	3	45030648	45030648	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:45030648A>G	ENST00000265564.7	+	2	122	c.74A>G	c.(73-75)gAt>gGt	p.D25G	EXOSC7_ENST00000461361.1_3'UTR	NM_015004.3	NP_055819.2	Q15024	EXOS7_HUMAN	exosome component 7	25					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding	p.D25G(1)		endometrium(3)|large_intestine(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		CTCCGTGTGGATGGCCGTGGC	0.522000													15	21					0	0	0.008871	0	0
ADCY2	108	broad.mit.edu	37	5	7695931	7695931	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:7695931C>A	ENST00000338316.4	+	6	1025	c.936C>A	c.(934-936)gtC>gtA	p.V312V	ADCY2_ENST00000537121.1_Silent_p.V132V	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	312					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.V312V(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GAGAACTAGTCCACATGCTGA	0.443000													13	50					7.93312e-07	9.51602e-07	0.002450	1	0
TRIML2	205860	broad.mit.edu	37	4	189012595	189012595	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:189012595C>A	ENST00000512729.1	-	7	1470	c.1096G>T	c.(1096-1098)Gac>Tac	p.D366Y	TRIML2_ENST00000326754.3_Missense_Mutation_p.D391Y	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	366	B30.2/SPRY.						ligase activity	p.D366Y(1)		central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GGACTTGTGTCTCCATTTGGG	0.463000													66	85					1.21705e-43	2.26975e-43	0.014410	1	0
ANXA11	311	broad.mit.edu	37	10	81926685	81926685	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:81926685C>T	ENST00000438331.1	-	8	1187	c.705G>A	c.(703-705)cgG>cgA	p.R235R	ANXA11_ENST00000265447.4_Silent_p.R235R|ANXA11_ENST00000372231.3_Silent_p.R235R|ANXA11_ENST00000535999.1_Silent_p.R235R|ANXA11_ENST00000537102.1_Silent_p.R202R|ANXA11_ENST00000360615.4_Silent_p.R235R|ANXA11_ENST00000422982.3_Silent_p.R235R	NM_145869.1	NP_665876.1	P50995	ANX11_HUMAN	annexin A11	235					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding	p.R235R(1)		endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|urinary_tract(1)	17	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGATCTGCTGCCGCTGCTTGT	0.647000													9	12					0	0	0.006214	0	0
ZNF827	152485	broad.mit.edu	37	4	146823533	146823533	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:146823533T>A	ENST00000508784.1	-	2	1105	c.878A>T	c.(877-879)gAg>gTg	p.E293V	ZNF827_ENST00000513320.1_Intron|ZNF827_ENST00000379448.4_Missense_Mutation_p.E293V			Q17R98	ZN827_HUMAN	zinc finger protein 827	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E293V(2)		NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGCGGCCACCTCCTTCAGAAG	0.587000													40	70					0	0	0.013114	0	0
TRIML1	339976	broad.mit.edu	37	4	189065202	189065202	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:189065202C>T	ENST00000332517.3	+	5	911	c.771C>T	c.(769-771)ctC>ctT	p.L257L	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	257					multicellular organismal development		ligase activity|zinc ion binding	p.L257L(1)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GCGAGCCACTCTTGCTTCAGT	0.562000													8	13					0	0	0.008291	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156910211	156910211	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:156910211C>A	ENST00000368194.3	-	36	4560	c.3521G>T	c.(3520-3522)gGg>gTg	p.G1174V	ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000361409.2_Missense_Mutation_p.G1134V|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.G550V	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1134					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	p.G1174V(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGCTGGGACCCAGTGCCTGT	0.602000													12	46					5.50884e-06	6.44168e-06	0.013537	1	0
PRR23A	729627	broad.mit.edu	37	3	138724774	138724774	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:138724774C>A	ENST00000383163.2	-	1	336	c.337G>T	c.(337-339)Gga>Tga	p.G113*	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	113								p.G113*(1)		endometrium(3)|kidney(1)|lung(7)	11						TCCTGCGCTCCTGAGCGTTCG	0.612000													11	34					3.86212e-05	4.44492e-05	0.008291	1	0
SPAST	6683	broad.mit.edu	37	2	32289037	32289037	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:32289037A>C	ENST00000315285.3	+	1	262	c.137A>C	c.(136-138)cAt>cCt	p.H46P	SPAST_ENST00000345662.1_Missense_Mutation_p.H46P	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	46	Required for interaction with ATL1.|Required for interaction with RTN1.|Required for midbody localization.|Required for nuclear localization.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity	p.H46P(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					gAGTCGCCGCATAAGCGGAAC	0.711000													6	24					0	0	0.004482	0	0
OR5T2	219464	broad.mit.edu	37	11	55999812	55999812	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:55999812G>C	ENST00000313264.4	-	1	925	c.850C>G	c.(850-852)Cta>Gta	p.L284V		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L284V(2)		endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					ACTCCAGTTAGGTGAGCTCCA	0.418000													53	204					0	0	0.014410	0	0
TIGIT	201633	broad.mit.edu	37	3	114026903	114026903	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:114026903C>T	ENST00000481065.1	+	5	3476	c.861C>T	c.(859-861)gcC>gcT	p.A287A	TIGIT_ENST00000486257.1_Silent_p.A220A|TIGIT_ENST00000383671.3_Silent_p.A220A			Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	220					negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding	p.A220A(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(1)	17						AGGACTGTGCCGAGCTGCATG	0.567000													31	204					0	0	0.005524	0	0
CAPN13	92291	broad.mit.edu	37	2	30977208	30977208	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:30977208A>T	ENST00000295055.8	-	9	1065	c.889T>A	c.(889-891)Tgt>Agt	p.C297S	CAPN13_ENST00000534090.2_Missense_Mutation_p.C297S	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	297	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity	p.C297S(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CGCGGATCACAGGTTTCCTCC	0.453000													3	19					0	0	0.004672	0	0
NCOA6	23054	broad.mit.edu	37	20	33328755	33328755	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr20:33328755C>A	ENST00000374796.2	-	12	7875	c.5305G>T	c.(5305-5307)Gat>Tat	p.D1769Y	NCOA6_ENST00000359003.2_Missense_Mutation_p.D1769Y			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1769	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.D1769Y(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CTAGCCTCATCTGGATTCAAT	0.517000													28	59					1.50538e-07	1.83155e-07	0.006320	1	0
PARD3B	117583	broad.mit.edu	37	2	206480498	206480498	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:206480498G>T	ENST00000406610.2	+	23	3786	c.3579G>T	c.(3577-3579)caG>caT	p.Q1193H	PARD3B_ENST00000351153.1_Missense_Mutation_p.Q1124H|PARD3B_ENST00000349953.3_Missense_Mutation_p.Q1092H|PARD3B_ENST00000358768.2_Missense_Mutation_p.Q1131H|PARD3B_ENST00000488622.1_3'UTR	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1193					cell cycle|cell division	endomembrane system|tight junction		p.Q1131_D1132>HY(1)|p.Q1132_D1133>HY(1)|p.Q1124_D1125>HY(1)		breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ACCGAACCCAGGATTCCCGGC	0.612000													40	71					9.73076e-26	1.67987e-25	0.006999	1	0
MUC16	94025	broad.mit.edu	37	19	9064676	9064676	+	Silent	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:9064676A>G	ENST00000397910.4	-	3	22973	c.22770T>C	c.(22768-22770)ccT>ccC	p.P7590P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7592	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.P7590P(2)|p.P3223P(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGACTGCTCAGGGCCTGACA	0.488000													3	98					0	0	0.004672	0	0
KCNK13	56659	broad.mit.edu	37	14	90650865	90650865	+	Missense_Mutation	SNP	G	G	A	rs115329697	byFrequency	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:90650865G>A	ENST00000282146.4	+	2	1186	c.745G>A	c.(745-747)Gcc>Acc	p.A249T		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	249						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.A249T(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CAGCCAGAACGCCCACTATGA	0.507000													26	97					0	0	0.007291	0	0
MYO1H	283446	broad.mit.edu	37	12	109853423	109853423	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:109853423A>T	ENST00000310903.5	+	15	1653	c.1547A>T	c.(1546-1548)aAg>aTg	p.K516M	MYO1H_ENST00000431443.2_Missense_Mutation_p.K526M			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity	p.K516M(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						TACTGCACCAAGGGTGAGTGG	0.562000													10	7					0	0	0.010729	0	0
CAPN7	23473	broad.mit.edu	37	3	15282026	15282026	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:15282026G>T	ENST00000253693.2	+	13	1707	c.1454G>T	c.(1453-1455)tGg>tTg	p.W485L		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	485	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity	p.W485L(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						CATTTACGTTGGAAAGGAAGA	0.348000													25	33					3.28513e-13	4.67604e-13	0.003954	1	0
HUNK	30811	broad.mit.edu	37	21	33371024	33371024	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:33371024A>G	ENST00000270112.2	+	11	2032	c.1672A>G	c.(1672-1674)Atg>Gtg	p.M558V		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	558					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity	p.M558V(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						GATGCTGGACATGGTGCGCTC	0.612000													9	40					0	0	0.006214	0	0
GFI1B	8328	broad.mit.edu	37	9	135865147	135865147	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:135865147C>T	ENST00000339463.3	+	10	1486	c.667C>T	c.(667-669)Cgc>Tgc	p.R223C	GFI1B_ENST00000372123.1_Missense_Mutation_p.R177C|GFI1B_ENST00000372124.1_Missense_Mutation_p.R177C|GFI1B_ENST00000534944.1_Missense_Mutation_p.R177C|GFI1B_ENST00000372122.1_Missense_Mutation_p.R223C|GFI1B_ENST00000450530.1_Missense_Mutation_p.R223C			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	223	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding	p.R223F(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CTTCGAGTGCCGCATGTGCGG	0.682000													16	13					0	0	0.008871	0	0
NBAS	51594	broad.mit.edu	37	2	15555760	15555760	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:15555760C>A	ENST00000281513.5	-	25	2872	c.2847G>T	c.(2845-2847)gtG>gtT	p.V949V	NBAS_ENST00000441750.1_Intron	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	949								p.V949V(1)		NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GCTCATTAGCCACACCAGGCG	0.383000													29	58					1.13719e-10	1.49001e-10	0.008361	1	0
KIAA1551	55196	broad.mit.edu	37	12	32137950	32137950	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:32137950G>C	ENST00000312561.4	+	4	4475	c.4061G>C	c.(4060-4062)gGa>gCa	p.G1354A	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551									p.G1354A(1)									AGTTCTTTGGGACAGTCATTA	0.343000													85	43					0	0	0.014410	0	0
CYYR1	116159	broad.mit.edu	37	21	27840859	27840859	+	Silent	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:27840859A>G	ENST00000299340.4	-	4	769	c.426T>C	c.(424-426)cgT>cgC	p.R142R	CYYR1_ENST00000435845.2_3'UTR|AP001596.6_ENST00000444306.1_RNA|AP001596.6_ENST00000429340.1_RNA|AP001597.1_ENST00000357401.3_RNA|AP001596.6_ENST00000421771.1_RNA|AP001597.1_ENST00000414486.1_RNA	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	142						integral to membrane		p.R142R(1)		large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GGGGTGGAGAACGCTGTGCTG	0.532000													7	50					0	0	0.003080	0	0
PTGFR	5737	broad.mit.edu	37	1	78959226	78959226	+	Splice_Site	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:78959226G>T	ENST00000370756.3	+	2	1035	c.798_splice	c.e2+1	p.L266_splice	PTGFR_ENST00000370757.3_Splice_Site_p.L266_splice|PTGFR_ENST00000370758.1_Splice_Site_p.L266_splice	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	266					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity	p.?(2)		breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GCCCATTTCTGGTAAGAGCCT	0.418000													5	44					0.00116845	0.00127308	0.001168	1	0
DNAH9	1770	broad.mit.edu	37	17	11865411	11865411	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:11865411T>A	ENST00000262442.3	+	68	13139	c.13071T>A	c.(13069-13071)acT>acA	p.T4357T	DNAH9_ENST00000454412.2_Silent_p.T4281T|DNAH9_ENST00000396001.2_Silent_p.T669T|RP11-1096G20.5_ENST00000580270.1_RNA	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4357					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.T4357T(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGTTCCTGACTGCCATCATGC	0.532000													16	38					0	0	0.006122	0	0
SCN2A	6326	broad.mit.edu	37	2	166243334	166243334	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:166243334A>T	ENST00000375437.2	+	26	4920	c.4630A>T	c.(4630-4632)Aac>Tac	p.N1544Y	SCN2A_ENST00000357398.3_Missense_Mutation_p.N1544Y|SCN2A_ENST00000375427.2_Missense_Mutation_p.N1544Y|SCN2A_ENST00000283256.6_Missense_Mutation_p.N1544Y	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1544					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.N1544Y(2)		NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CATCTGCCTTAACATGGTCAC	0.368000													28	53					0	0	0.007291	0	0
MME	4311	broad.mit.edu	37	3	154889939	154889939	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:154889939G>C	ENST00000460393.1	+	21	2134	c.2014G>C	c.(2014-2016)Gaa>Caa	p.E672Q	MME_ENST00000492661.1_Missense_Mutation_p.E672Q|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000462745.1_Missense_Mutation_p.E672Q|MME_ENST00000360490.2_Missense_Mutation_p.E672Q|MME_ENST00000493237.1_Missense_Mutation_p.E672Q	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	672					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.E672Q(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GAATGGCGAAGAAAAATTACT	0.284000													6	66					0	0	0.003080	0	0
TTC18	118491	broad.mit.edu	37	10	75072314	75072314	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr10:75072314T>A	ENST00000310715.3	-	11	1330	c.1210A>T	c.(1210-1212)Aaa>Taa	p.K404*	TTC18_ENST00000340329.3_Intron|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000401621.2_Nonsense_Mutation_p.K404*|TTC18_ENST00000394865.1_Nonsense_Mutation_p.K404*	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	404							binding	p.K404*(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					ACAGCTTGTTTGGACAGCAGA	0.378000													55	168					0	0	0.014410	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	43					0	0	0.000602	0	0
RP1L1	94137	broad.mit.edu	37	8	10480543	10480543	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:10480543C>T	ENST00000382483.3	-	2	392	c.169G>A	c.(169-171)Gcc>Acc	p.A57T	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	57					intracellular signal transduction			p.A57T(1)		breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GTCTTAAAGGCGCGCTGGTGA	0.647000													24	52					0	0	0.003954	0	0
CATSPERB	79820	broad.mit.edu	37	14	92054420	92054420	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:92054420G>A	ENST00000256343.3	-	25	3115	c.2959C>T	c.(2959-2961)Cac>Tac	p.H987Y		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	987					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.H987Y(1)		NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GGCACAGTGTGTTCTAAAAAT	0.299000													11	17					0	0	0.010729	0	0
KMT2B	9757	broad.mit.edu	37	19	36218608	36218608	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:36218608G>A	ENST00000222270.7	+	17	4312	c.4312G>A	c.(4312-4314)Gat>Aat	p.D1438N	WBP7_ENST00000420124.1_Missense_Mutation_p.D1438N|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1												p.D1440N(1)									GTGTGGGCCAGATGGGAAGCA	0.652000													30	37					0	0	0.012213	0	0
ZNF524	147807	broad.mit.edu	37	19	56114114	56114114	+	Silent	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr19:56114114G>T	ENST00000591046.1	+	1	870	c.636G>T	c.(634-636)acG>acT	p.T212T	ZNF524_ENST00000301073.3_Silent_p.T212T			Q96C55	ZN524_HUMAN	zinc finger protein 524	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T212T(1)		breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AGGCCAACACGCTCCGGCGCC	0.706000													8	16					1.76689e-08	2.17562e-08	0.006214	1	0
ZAN	7455	broad.mit.edu	37	7	100349490	100349490	+	RNA	SNP	A	A	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:100349490A>G	ENST00000542585.1	+	0	1910				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.K588E(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CACAGTCCCCAAAGAAAAGCC	0.468000													24	99					0	0	0.003330	0	0
DNAH2	146754	broad.mit.edu	37	17	7705029	7705029	+	Splice_Site	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:7705029G>A	ENST00000572933.1	+	57	10292		c.e57+1		DNAH2_ENST00000389173.2_Splice_Site			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.?(1)		NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAGGAGAATGTGAGcccctc	0.612000													12	83					0	0	0.001855	0	0
GPR150	285601	broad.mit.edu	37	5	94956174	94956174	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:94956174C>T	ENST00000380007.2	+	1	393	c.195C>T	c.(193-195)tgC>tgT	p.C65C		NM_199243.1	NP_954713.1	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	65						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.C65C(1)		lung(2)	2		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		CAGTGCTGTGCCGCCTGTgcg	0.736000													8	10					0	0	0.008291	0	0
RGS6	9628	broad.mit.edu	37	14	72924983	72924983	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr14:72924983A>C	ENST00000553530.1	+	5	447	c.240A>C	c.(238-240)gaA>gaC	p.E80D	RGS6_ENST00000556437.1_Missense_Mutation_p.E80D|RGS6_ENST00000434263.2_Missense_Mutation_p.E11D|RGS6_ENST00000553525.1_Missense_Mutation_p.E80D|RGS6_ENST00000404301.2_Missense_Mutation_p.E80D|RGS6_ENST00000406236.4_Missense_Mutation_p.E80D|RGS6_ENST00000355512.6_Missense_Mutation_p.E80D|RGS6_ENST00000407322.4_Missense_Mutation_p.E80D|RGS6_ENST00000553690.1_3'UTR|RGS6_ENST00000555571.1_Missense_Mutation_p.E80D|RGS6_ENST00000402788.2_Missense_Mutation_p.E80D|RGS6_ENST00000343854.6_Missense_Mutation_p.E80D	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	80	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity	p.E80D(1)		endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TTACAGTTGAAGCAATACACT	0.458000													11	85					0	0	0.010729	0	0
IGSF5	150084	broad.mit.edu	37	21	41143096	41143096	+	Silent	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:41143096C>A	ENST00000380588.4	+	4	775	c.672C>A	c.(670-672)gcC>gcA	p.A224A	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	224	Ig-like V-type 2.					integral to membrane|tight junction		p.A224A(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				GCCTGAAGGCCCGCAAGTCTG	0.488000													17	63					1.67942e-08	2.08296e-08	0.006122	1	0
CCKAR	886	broad.mit.edu	37	4	26490990	26490990	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:26490990T>G	ENST00000295589.3	-	2	423	c.229A>C	c.(229-231)Aac>Cac	p.N77H		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	77					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity	p.N77H(1)		NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	AGGAAGATGTTGGTGACCGTC	0.537000													18	50					0	0	0.014323	0	0
OR10J1	26476	broad.mit.edu	37	1	159410315	159410315	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:159410315C>T	ENST00000423932.3	+	1	804	c.767C>T	c.(766-768)aCt>aTt	p.T256I	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	256					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity	p.T256I(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TCCCACCTCACTGTGGTCATT	0.488000													41	59					0	0	0.009718	0	0
TBC1D32	221322	broad.mit.edu	37	6	121401997	121401997	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:121401997C>G	ENST00000275159.6	-	33	3816	c.3817G>C	c.(3817-3819)Gaa>Caa	p.E1273Q	TBC1D32_ENST00000398197.2_5'UTR|TBC1D32_ENST00000398212.2_Missense_Mutation_p.E1232Q					TBC1 domain family, member 32									p.E1232Q(1)									TCCATGTATTCAAAATAATCA	0.383000													44	44					0	0	0.014410	0	0
DOK2	9046	broad.mit.edu	37	8	21769797	21769797	+	Silent	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr8:21769797C>T	ENST00000276420.4	-	2	546	c.288G>A	c.(286-288)gcG>gcA	p.A96A	DOK2_ENST00000544659.1_5'UTR	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	96	PH.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding	p.A96A(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		CTGCAGGGGCCGCCAGGAGGT	0.731000													3	5					0	0	0.009096	0	0
CACNG3	10368	broad.mit.edu	37	16	24268274	24268274	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr16:24268274T>A	ENST00000005284.3	+	1	1401	c.199T>A	c.(199-201)Tgc>Agc	p.C67S		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	67					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.C67S(1)		NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		GTGGAGGACCTGCTGCCTAGA	0.428000													17	45					0	0	0.006122	0	0
POU5F2	134187	broad.mit.edu	37	5	93076803	93076803	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:93076803C>A	ENST00000510627.4	-	1	540	c.467G>T	c.(466-468)gGg>gTg	p.G156V	FAM172A_ENST00000509163.1_Intron|FAM172A_ENST00000505869.1_Intron|POU5F2_ENST00000606183.1_5'UTR|FAM172A_ENST00000395965.3_Intron|FAM172A_ENST00000509739.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	156	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		AAGCACCTTCCCAAACAGAGC	0.572000													8	36					0.00829132	0.00891971	0.008291	1	0
PLXNA4	91584	broad.mit.edu	37	7	131925827	131925827	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:131925827G>T	ENST00000359827.3	-	5	2564	c.1602C>A	c.(1600-1602)aaC>aaA	p.N534K	PLXNA4_ENST00000321063.4_Missense_Mutation_p.N534K			Q9HCM2	PLXA4_HUMAN	plexin A4	534	PSI 1.					integral to membrane|intracellular|plasma membrane		p.N534K(2)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GTACTCACGTGTTGTGCAGCA	0.592000													5	55					0.000602214	0.00066753	0.000602	1	0
PER3	8863	broad.mit.edu	37	1	7890002	7890002	+	Silent	SNP	C	C	T	rs57875989		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:7890002C>T	ENST00000377532.3	+	18	3219	c.2995C>T	c.(2995-2997)Ctg>Ttg	p.L999L	PER3_ENST00000361923.2_Silent_p.L990L			P56645	PER3_HUMAN	period circadian clock 3	990	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity	p.L990L(1)		breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCAGCGCTCTGTCCACAGG	0.577000													18	76					0	0	0.010504	0	0
CPEB1	64506	broad.mit.edu	37	15	83226624	83226624	+	Silent	SNP	T	T	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr15:83226624T>A	ENST00000563800.1	-	4	2298	c.573A>T	c.(571-573)tcA>tcT	p.S191S	CPEB1_ENST00000562019.1_Silent_p.S164S|CPEB1_ENST00000564522.1_Silent_p.S89S|CPEB1_ENST00000568757.1_Silent_p.S89S|CPEB1_ENST00000568128.1_Silent_p.S164S|CPEB1_ENST00000398592.2_Intron|CPEB1_ENST00000398591.2_Silent_p.S89S|CPEB1_ENST00000450751.2_Silent_p.S89S|CPEB1_ENST00000423133.2_Silent_p.S89S|CPEB1_ENST00000261723.6_Silent_p.S167S|RP11-379H8.1_ENST00000568285.1_Intron			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	164	Ser-rich.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding	p.S164S(1)|p.S89S(1)		breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATCCTCTAACTGAGGGTGCTG	0.562000													42	40					0	0	0.014410	0	0
KIDINS220	57498	broad.mit.edu	37	2	8919174	8919174	+	Silent	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:8919174C>G	ENST00000256707.3	-	19	2647	c.2466G>C	c.(2464-2466)gtG>gtC	p.V822V	KIDINS220_ENST00000473731.1_Silent_p.V822V|KIDINS220_ENST00000319688.5_Silent_p.V823V|KIDINS220_ENST00000427284.1_Silent_p.V822V|KIDINS220_ENST00000418530.1_Silent_p.V780V	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	822	KAP NTPase.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane		p.V822V(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AATCCCGAAGCACACTATTGA	0.408000													32	194					0	0	0.012213	0	0
NME5	8382	broad.mit.edu	37	5	137454515	137454515	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:137454515C>A	ENST00000265191.2	-	5	596	c.547G>T	c.(547-549)Gat>Tat	p.D183Y		NM_003551.2	NP_003542.1	P56597	NDK5_HUMAN	NME/NM23 family member 5	183					anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding	p.D183Y(1)		kidney(1)|large_intestine(1)|lung(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACCAAAGGATCTGCTGGTTTT	0.433000													11	72					0.000673444	0.000740064	0.008291	1	0
LPPR5	163404	broad.mit.edu	37	1	99418635	99418635	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:99418635C>T	ENST00000370188.3	-	3	972	c.612G>A	c.(610-612)atG>atA	p.M204I	LPPR5_ENST00000263177.4_Missense_Mutation_p.M204I	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		204						integral to membrane	hydrolase activity	p.M204I(1)									CGGTCAGATACATAGCTGCAT	0.393000													15	66					0	0	0.004007	0	0
TENM2	57451	broad.mit.edu	37	5	167489128	167489128	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:167489128C>G	ENST00000519204.1	+	6	1128	c.1010C>G	c.(1009-1011)aCa>aGa	p.T337R	TENM2_ENST00000520394.1_Missense_Mutation_p.T226R|TENM2_ENST00000545108.1_Missense_Mutation_p.T458R|TENM2_ENST00000403607.2_Missense_Mutation_p.T291R|TENM2_ENST00000518659.1_Missense_Mutation_p.T458R					teneurin transmembrane protein 2									p.T337R(1)|p.T458R(1)|p.T291R(1)									CGGCGGGTAACACAAGAAGTC	0.468000													10	14					0	0	0.010729	0	0
CYLC2	1539	broad.mit.edu	37	9	105767378	105767378	+	Silent	SNP	A	A	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:105767378A>T	ENST00000374798.3	+	5	535	c.465A>T	c.(463-465)ctA>ctT	p.L155L	CYLC2_ENST00000487798.1_Silent_p.L155L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	155	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton	p.D156Y(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aagaaaagctagatgcaaaga	0.358000													20	9					0	0	0.007413	0	0
DBN1	1627	broad.mit.edu	37	5	176885479	176885479	+	Silent	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr5:176885479G>A	ENST00000292385.5	-	13	1971	c.1362C>T	c.(1360-1362)acC>acT	p.T454T	DBN1_ENST00000393563.4_Silent_p.T184T|DBN1_ENST00000512501.1_Silent_p.T184T|DBN1_ENST00000309007.5_Silent_p.T452T|DBN1_ENST00000393565.1_Silent_p.T498T	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	452					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding	p.T454T(1)|p.T452T(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGTTTCAATGGTGTCAGCTG	0.607000													38	80					0	0	0.014410	0	0
ASB15	142685	broad.mit.edu	37	7	123269175	123269175	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr7:123269175C>A	ENST00000451558.1	+	12	1648	c.1127C>A	c.(1126-1128)cCa>cAa	p.P376Q	ASB15_ENST00000540573.1_Missense_Mutation_p.P376Q|ASB15_ENST00000451215.1_Missense_Mutation_p.P376Q|ASB15_ENST00000275699.3_Missense_Mutation_p.P376Q|ASB15_ENST00000434204.1_Missense_Mutation_p.P376Q			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	376					intracellular signal transduction			p.P376Q(1)		breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						GGTGCAGACCCAAACTTAGAT	0.453000													16	142					3.41278e-10	4.40387e-10	0.004990	1	0
UBQLN1	29979	broad.mit.edu	37	9	86278912	86278912	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:86278912C>A	ENST00000376395.4	-	10	2018	c.1495G>T	c.(1495-1497)Gga>Tga	p.G499*	UBQLN1_ENST00000257468.7_Nonsense_Mutation_p.G471*	NM_013438.4|NM_053067.2	NP_038466.2|NP_444295.1	Q9UMX0	UBQL1_HUMAN	ubiquilin 1	499					apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding	p.G499*(1)		breast(4)|endometrium(2)|kidney(4)|large_intestine(6)|lung(10)|prostate(1)	27						CCATTAGTTCCCGAAGAGCCT	0.493000													80	70					7.68447e-34	1.38755e-33	0.014410	1	0
PCDH17	27253	broad.mit.edu	37	13	58299073	58299073	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:58299073C>A	ENST00000377918.3	+	4	3151	c.3125C>A	c.(3124-3126)gCg>gAg	p.A1042E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1042					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.A1042E(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCAACCAAGGCGTGCATCGAG	0.532000													21	43					9.95505e-16	1.50504e-15	0.014323	1	0
OTOGL	283310	broad.mit.edu	37	12	80752535	80752535	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr12:80752535G>T	ENST00000458043.2	+	50	6185	c.6179G>T	c.(6178-6180)tGt>tTt	p.C2060F	OTOGL_ENST00000546620.1_Missense_Mutation_p.C79F|OTOGL_ENST00000547103.1_Missense_Mutation_p.C2048F	NM_173591.3	NP_775862.3			otogelin-like									p.C425F(1)|p.C2060F(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCTGGTCAATGTTGCCCAACA	0.294000													19	9					2.37509e-13	3.41879e-13	0.010504	1	0
DOCK3	1795	broad.mit.edu	37	3	51264852	51264852	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:51264852C>A	ENST00000266037.9	+	16	1539	c.1516C>A	c.(1516-1518)Cgc>Agc	p.R506S		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	506	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.R495S(1)|p.R506S(1)		breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CTCCCACCTGCGCTTTGAGTT	0.468000													31	34					3.11337e-16	4.74906e-16	0.013726	1	0
OR5M9	390162	broad.mit.edu	37	11	56230498	56230498	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:56230498G>T	ENST00000279791.1	-	1	379	c.380C>A	c.(379-381)cCt>cAt	p.P127H		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P127H(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					ATAAAGCAGAGGGTTGCAGCC	0.493000													19	77					9.90768e-06	1.15326e-05	0.004656	1	0
PALMD	54873	broad.mit.edu	37	1	100154432	100154432	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr1:100154432G>A	ENST00000263174.4	+	7	991	c.616G>A	c.(616-618)Gga>Aga	p.G206R	PALMD_ENST00000605497.1_Missense_Mutation_p.G206R	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	206					regulation of cell shape	cytoplasm|membrane		p.G206R(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		TAAAGGTACAGGAATAAAAGT	0.393000													21	74					0	0	0.003330	0	0
MGAT5	4249	broad.mit.edu	37	2	135075164	135075164	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:135075164delG	ENST00000409645.1	+	4	723	c.471delG	c.(469-471)gafs	p.E157fs	MGAT5_ENST00000281923.2_Frame_Shift_Del_p.E157fs			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	157					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CTCACTGTGAGGGAAAGATCA	0.438													14	37	---	---	---	---					
LRP1B	53353	broad.mit.edu	37	2	141128282	141128282	+	Frame_Shift_Del	DEL	T	T	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:141128282delT	ENST00000389484.3	-	71	11976	c.11005delA	c.(11005-11007)gafs	p.R3669fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3669					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCTTACCTCTTTCACAGTTC	0.403										TSP Lung(27;0.18)			94	173	---	---	---	---					
KCNH7	90134	broad.mit.edu	37	2	163279808	163279808	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr2:163279808delC	ENST00000328032.4	-	8	2382	c.2171delG	c.(2170-2172)gcfs	p.G724fs	KCNH7_ENST00000332142.5_Intron	NM_173162.2	NP_775185.1	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	0					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CACTATAATGCCTGCGGCACT	0.423													59	112	---	---	---	---					
ILDR1	286676	broad.mit.edu	37	3	121712106	121712106	+	Frame_Shift_Del	DEL	C	C	-	rs146620043		TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:121712106delC	ENST00000273691.3	-	6	1463	c.1358delG	c.(1357-1359)ccfs	p.R453fs	ILDR1_ENST00000393631.1_Frame_Shift_Del_p.R408fs|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Frame_Shift_Del_p.R465fs|ILDR1_ENST00000344209.5_Frame_Shift_Del_p.R497fs	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	497	Arg-rich.		R -> Q (in DFNB42; uncertain pathological significance).			cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GTGCGAGCCGCGGCGGTGGGC	0.632													20	17	---	---	---	---					
PIK3R4	30849	broad.mit.edu	37	3	130463531	130463549	+	Frame_Shift_Del	DEL	CTTCTGGAAGATAAGTGGG	CTTCTGGAAGATAAGTGGG	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr3:130463531_130463549delCTTCTGGAAGATAAGTGGG	ENST00000356763.3	-	2	1071_1089	c.514_532delCCCACTTATCTTCCAGAAG	c.(514-534)acfs	p.PTYLPED172fs		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	172	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity	p.T173T(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						GCCGGGTTGTCTTCTGGAAGATAAGTGGGCTTAAAACTG	0.434													15	87	---	---	---	---					
SPOCK3	50859	broad.mit.edu	37	4	167663162	167663163	+	Frame_Shift_Ins	INS	-	-	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr4:167663162_167663163insC	ENST00000357154.3	-	10	1125_1126	c.988_989insG	c.(988-990)aaafs	p.K330fs	SPOCK3_ENST00000511531.1_Frame_Shift_Ins_p.K330fs|SPOCK3_ENST00000504953.1_Frame_Shift_Ins_p.K327fs|SPOCK3_ENST00000511269.1_Frame_Shift_Ins_p.K327fs|SPOCK3_ENST00000541354.1_Frame_Shift_Ins_p.K210fs|SPOCK3_ENST00000535728.1_Frame_Shift_Ins_p.K198fs|SPOCK3_ENST00000502330.1_Frame_Shift_Ins_p.K330fs|SPOCK3_ENST00000534949.1_Frame_Shift_Ins_p.K234fs|SPOCK3_ENST00000510741.1_Frame_Shift_Ins_p.K287fs|SPOCK3_ENST00000357545.4_Frame_Shift_Ins_p.K327fs|SPOCK3_ENST00000541637.1_Frame_Shift_Ins_p.K232fs|SPOCK3_ENST00000421836.2_Frame_Shift_Ins_p.K279fs|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000506886.1_Frame_Shift_Ins_p.K330fs|SPOCK3_ENST00000512681.1_Frame_Shift_Ins_p.K232fs	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	330	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GAGCTTCTTTACCCCTTGCCGC	0.376													19	90	---	---	---	---					
DEFB112	245915	broad.mit.edu	37	6	50016286	50016286	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:50016286delC	ENST00000322246.4	-	1	78	c.79delG	c.(79-81)aafs	p.E27fs		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	27					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					CGGGCCTTTTCAAATATTGTG	0.318													49	64	---	---	---	---					
GCLC	2729	broad.mit.edu	37	6	53372308	53372311	+	Frame_Shift_Del	DEL	TATC	TATC	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr6:53372308_53372311delTATC	ENST00000229416.6	-	9	1534_1537	c.1051_1054delGATA	c.(1051-1056)aafs	p.DK351fs		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	351					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TAGATCTCTTTATCTATCGTCAAG	0.373													63	132	---	---	---	---					
PKN3	29941	broad.mit.edu	37	9	131467820	131467820	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr9:131467820delC	ENST00000291906.4	+	2	656	c.263delC	c.(262-264)gtfs	p.A88fs		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	88					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						CCTGGCCCAGCTGGTGAGTGA	0.692													2	4	---	---	---	---					
PRR5L	79899	broad.mit.edu	37	11	36484020	36484021	+	Frame_Shift_Ins	INS	-	-	T			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr11:36484020_36484021insT	ENST00000378867.3	+	10	1196_1197	c.841_842insT	c.(841-843)ggafs	p.G281fs	PRR5L_ENST00000389693.3_3'UTR|PRR5L_ENST00000530639.1_Frame_Shift_Ins_p.G281fs|PRR5L_ENST00000311599.5_Frame_Shift_Ins_p.G208fs	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	281										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						GGAAGCCTACCTGGAGAAGTGT	0.634													40	30	---	---	---	---					
CSNK1A1L	122011	broad.mit.edu	37	13	37679171	37679171	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr13:37679171delG	ENST00000379800.3	-	1	632	c.223delC	c.(223-225)acfs	p.H75fs		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	75	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CAGTGCATGTGGGGGATGCCA	0.493													34	195	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7749462	7749462	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:7749462delC	ENST00000254846.5	+	6	692	c.303delC	c.(301-303)ctfs	p.L101fs	KDM6B_ENST00000448097.2_Frame_Shift_Del_p.L101fs	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	101					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						AGGCATTGCTCCGGGAGCCAG	0.637													20	52	---	---	---	---					
KRT14	3861	broad.mit.edu	37	17	39742827	39742827	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:39742827delC	ENST00000167586.6	-	1	346	c.260delG	c.(259-261)gafs	p.G87fs		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	87	Head.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				accaccatatcctcccccaaa	0.637													13	28	---	---	---	---					
TANC2	26115	broad.mit.edu	37	17	61432309	61432309	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr17:61432309delG	ENST00000424789.2	+	12	1922	c.1918delG	c.(1918-1920)gcfs	p.G640fs	TANC2_ENST00000389520.4_Frame_Shift_Del_p.G640fs	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	640							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						TACTACATTTGGCAAACTCAG	0.423													33	209	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-73-4666-01A-01D-1265-08	TCGA-73-4666-11A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f49fc77e-03cd-423c-b3e1-18bb19568650	cd39ef64-de54-4f7b-abd8-5bee411ce8dd	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													4	3	---	---	---	---					
