Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF81	347344	broad.mit.edu	37	X	47774812	47774812	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:47774812G>C	ENST00000376954.1	+	6	1135	c.767G>C	c.(766-768)aGc>aCc	p.S256T	ZNF81_ENST00000338637.7_Missense_Mutation_p.S256T			P51508	ZNF81_HUMAN	zinc finger protein 81	256						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				AAAGTCCTCAGCCTCAAACAC	0.403000													19	43					0	0	0.091800	0	0
TPSD1	23430	broad.mit.edu	37	16	1308080	1308080	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr16:1308080C>A	ENST00000211076.3	+	4	689	c.541C>A	c.(541-543)Ccg>Acg	p.P181T	TPSD1_ENST00000397534.2_Missense_Mutation_p.P174T	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	181	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				GCCGCCATACCCGCTGAAGGA	0.657000													3	9					0.004672	0.00479495	0.004672	1	0
ROR2	4920	broad.mit.edu	37	9	94487237	94487237	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:94487237C>A	ENST00000375708.3	-	9	1737	c.1539G>T	c.(1537-1539)gcG>gcT	p.A513A	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Silent_p.A373A	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	513	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGGGCCCCTCCGCTTTGTCCT	0.642000													42	88					1.61863e-15	2.13988e-15	0.048971	1	0
SLC45A2	51151	broad.mit.edu	37	5	33947279	33947279	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:33947279C>T	ENST00000382102.3	-	6	1414	c.1357G>A	c.(1357-1359)Gaa>Aaa	p.E453K	SLC45A2_ENST00000296589.4_Missense_Mutation_p.E453K|SLC45A2_ENST00000342059.3_Missense_Mutation_p.E394K	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	453					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						TCCTTTTCTTCCTCGCGGTGG	0.512000													99	194					0	0	0.048971	0	0
CELA3A	10136	broad.mit.edu	37	1	22329535	22329535	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:22329535G>T	ENST00000290122.3	+	2	102	c.83G>T	c.(82-84)cGc>cTc	p.R28L	CELA3A_ENST00000374663.1_Missense_Mutation_p.R28L	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTTCCAGCCGCGTTGTCCAT	0.602000													43	89					5.73376e-24	8.43836e-24	0.048971	1	0
KCNT2	343450	broad.mit.edu	37	1	196342361	196342361	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:196342361C>A	ENST00000367433.5	-	14	1413	c.1312G>T	c.(1312-1314)Gaa>Taa	p.E438*	KCNT2_ENST00000367431.4_Nonsense_Mutation_p.E438*|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Nonsense_Mutation_p.E49*|KCNT2_ENST00000294725.8_Nonsense_Mutation_p.E438*			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	438	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTAAACTCTTCTTCACAAACA	0.289000													35	139					1.8453e-21	2.57023e-21	0.039052	1	0
NUFIP2	57532	broad.mit.edu	37	17	27620945	27620945	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:27620945G>T	ENST00000225388.4	-	1	191	c.133C>A	c.(133-135)Cac>Aac	p.H45N	NUFIP2_ENST00000579665.1_Missense_Mutation_p.H45N	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	45	His-rich.					nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			tggtggtggtggttgtggctg	0.587000													4	131					1.024e-07	1.20108e-07	0.014758	1	0
POMGNT2	84892	broad.mit.edu	37	3	43122492	43122492	+	Silent	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:43122492G>C	ENST00000344697.2	-	2	777	c.432C>G	c.(430-432)ccC>ccG	p.P144P	GTDC2_ENST00000441964.1_Silent_p.P144P	NM_032806.4	NP_116195.2																					ACACCGGCTTGGGCATGAAGC	0.597000													14	99					0	0	0.024245	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66988902	66988902	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:66988902G>T	ENST00000276570.5	+	4	414	c.127G>T	c.(127-129)Gcc>Tcc	p.A43S	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	43	J.			KLAL -> LENP (in Ref. 3; CAB63773).	protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AAGAAAATTGGCCCTGAAACA	0.368000													30	115					2.52637e-11	3.07902e-11	0.080422	1	0
ROBO2	6092	broad.mit.edu	37	3	77666736	77666736	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:77666736G>T	ENST00000461745.1	+	22	4266	c.3366G>T	c.(3364-3366)ctG>ctT	p.L1122L	ROBO2_ENST00000487694.3_Silent_p.L1138L|ROBO2_ENST00000469233.1_3'UTR|ROBO2_ENST00000332191.8_Silent_p.L1122L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1122					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AAGATGAACTGGAAGAAGATG	0.458000													17	80					1.45105e-14	1.88637e-14	0.038395	1	0
AP4M1	9179	broad.mit.edu	37	7	99700336	99700336	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr7:99700336C>T	ENST00000429084.1	+	3	365	c.207C>T	c.(205-207)agC>agT	p.S69S	AP4M1_ENST00000422582.1_5'UTR|AP4M1_ENST00000359593.4_Silent_p.S62S|AP4M1_ENST00000421755.1_Silent_p.S62S|AP4M1_ENST00000478501.1_3'UTR			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	62					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCAGACACAGCGGCCTCTATT	0.527000													7	67					0	0	0.029380	0	0
NR3C1	2908	broad.mit.edu	37	5	142779500	142779500	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:142779500C>A	ENST00000343796.2	-	2	1898	c.905G>T	c.(904-906)tGt>tTt	p.C302F	NR3C1_ENST00000394466.2_Missense_Mutation_p.C302F|NR3C1_ENST00000503201.1_Missense_Mutation_p.C302F|NR3C1_ENST00000504572.1_Missense_Mutation_p.C302F|NR3C1_ENST00000394464.2_Missense_Mutation_p.C302F|NR3C1_ENST00000416954.2_Intron|NR3C1_ENST00000424646.2_Missense_Mutation_p.C302F|NR3C1_ENST00000415690.2_Missense_Mutation_p.C302F|NR3C1_ENST00000231509.3_Missense_Mutation_p.C302F	NM_001018074.1|NM_001018075.1|NM_001018077.1	NP_001018084.1|NP_001018085.1|NP_001018087.1	P04150	GCR_HUMAN	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	302	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	GCTTGCCTGACAGTAAACTGT	0.423000													35	85					7.05121e-23	1.00916e-22	0.039052	1	0
LCT	3938	broad.mit.edu	37	2	136562358	136562358	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr2:136562358C>A	ENST00000264162.2	-	10	4453	c.4443G>T	c.(4441-4443)ctG>ctT	p.L1481L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1481	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGCTGGCGGCCAGCAGTGTAT	0.562000													18	70					1.32003e-05	1.47089e-05	0.108266	1	0
HOXA6	3203	broad.mit.edu	37	7	27185328	27185328	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr7:27185328G>A	ENST00000222728.3	-	2	675	c.651C>T	c.(649-651)atC>atT	p.I217I	HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000518848.1_RNA|HOXA6_ENST00000521478.1_5'UTR|HOXA3_ENST00000467897.2_Intron	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	217						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						GCGTGGAATTGATGAGCTTGT	0.612000													47	99					0	0	0.048971	0	0
ATP1A1	476	broad.mit.edu	37	1	116941354	116941354	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:116941354G>A	ENST00000537345.1	+	16	2599	c.2236G>A	c.(2236-2238)Gct>Act	p.A746T	ATP1A1_ENST00000295598.5_Missense_Mutation_p.A746T|ATP1A1_ENST00000369496.4_Missense_Mutation_p.A715T	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	746					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	CAAGCAAGCTGCTGACATGAT	0.468000													46	45					0	0	0.048971	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								4	78					0	0	0.009096	0	0
C8orf76	84933	broad.mit.edu	37	8	124253515	124253515	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:124253515C>T	ENST00000276704.4	-	1	123	c.72G>A	c.(70-72)cgG>cgA	p.R24R	ZHX1-C8ORF76_ENST00000357082.4_Intron|C8orf76_ENST00000521310.1_5'UTR	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	24							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGGTCCTGACCGCCGCTCCG	0.711000													7	22					0	0	0.047766	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45198039	45198039	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:45198039G>T	ENST00000352766.7	+	9	924	c.924G>T	c.(922-924)ctG>ctT	p.L308L	PRR5-ARHGAP8_ENST00000361473.5_Silent_p.L185L|ARHGAP8_ENST00000356099.6_Silent_p.L54L|ARHGAP8_ENST00000517296.3_Silent_p.L308L|ARHGAP8_ENST00000336963.4_Silent_p.L54L|ARHGAP8_ENST00000389774.2_Silent_p.L54L|ARHGAP8_ENST00000389773.5_Silent_p.L176L																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						ACCAGCGGCTGCTGGAGTAAG	0.592000													38	70					1.61572e-30	2.47111e-30	0.039052	1	0
SYCP2	10388	broad.mit.edu	37	20	58489197	58489197	+	Silent	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr20:58489197T>A	ENST00000357552.3	-	11	969	c.744A>T	c.(742-744)gcA>gcT	p.A248A	SYCP2_ENST00000371001.2_Silent_p.A248A			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	248					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding	p.A248A(1)		NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TTCTTTTAAATGCCTTAGCAA	0.289000													12	46					0	0	0.105934	0	0
ABCA13	154664	broad.mit.edu	37	7	48634392	48634392	+	Silent	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr7:48634392G>C	ENST00000435803.1	+	58	14751	c.14727G>C	c.(14725-14727)gcG>gcC	p.A4909A	ABCA13_ENST00000544596.1_Silent_p.A639A	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4909	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GCTGTGCTGCGGTGCTGACCT	0.502000													31	101					0	0	0.054565	0	0
ZFP30	22835	broad.mit.edu	37	19	38126058	38126058	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:38126058C>G	ENST00000351218.2	-	6	1941	c.1384G>C	c.(1384-1386)Ggt>Cgt	p.G462R	ZFP30_ENST00000392144.1_Missense_Mutation_p.G462R|ZFP30_ENST00000514101.2_Missense_Mutation_p.G462R|ZFP30_ENST00000589018.1_Intron	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGCTTTTCACCAGTATGAATA	0.373000													28	34					0	0	0.034045	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764153	77764153	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:77764153G>T	ENST00000521891.2	+	10	5444	c.4996G>T	c.(4996-4998)Gat>Tat	p.D1666Y	ZFHX4_ENST00000518282.1_Missense_Mutation_p.D1640Y|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D1621Y|ZFHX4_ENST00000455469.2_Missense_Mutation_p.D1621Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1621	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACCCATTTAGATGCCAAAGA	0.448000										HNSCC(33;0.089)			30	50					1.76533e-06	2.03993e-06	0.064281	1	0
CACNA1E	777	broad.mit.edu	37	1	181764126	181764126	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:181764126C>T	ENST00000526775.1	+	44	6133	c.5968C>T	c.(5968-5970)Cgg>Tgg	p.R1990W	CACNA1E_ENST00000367573.2_Missense_Mutation_p.R2052W|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R2009W|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1616W|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R2033W|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1941W|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R2003W	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2052					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GTCCCGTCGCCGGAGTTACCA	0.527000													6	83					0	0	0.058154	0	0
ADAM33	80332	broad.mit.edu	37	20	3655458	3655458	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr20:3655458G>T	ENST00000356518.2	-	5	613	c.372C>A	c.(370-372)ccC>ccA	p.P124P	ADAM33_ENST00000379861.4_Silent_p.P124P|ADAM33_ENST00000350009.2_Silent_p.P124P	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	124					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						CCCAGGAGTCGGGGAAGCCCC	0.632000													4	42					0.000602214	0.000634767	0.014758	1	0
REN	5972	broad.mit.edu	37	1	204124295	204124295	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:204124295C>A	ENST00000367195.2	-	9	1104	c.1061G>T	c.(1060-1062)aGt>aTt	p.S354I	REN_ENST00000272190.8_Missense_Mutation_p.S357I			P00797	RENI_HUMAN	renin	357					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CTTTTTACTACTGTAGGATTC	0.562000													20	98					4.72057e-08	5.57886e-08	0.091800	1	0
HK3	3101	broad.mit.edu	37	5	176317672	176317672	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:176317672C>A	ENST00000292432.5	-	6	685	c.594G>T	c.(592-594)gtG>gtT	p.V198V		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	198	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGCTGGACCACATCCTGGC	0.597000													112	301					1.4068e-65	2.28605e-65	0.048971	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256740	140256740	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:140256740C>T	ENST00000398631.2	+	1	1683	c.1683C>T	c.(1681-1683)aaC>aaT	p.N561N	PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCGCCGGCAC	0.697000													52	127					0	0	0.048971	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000492078.1_5'UTR|TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													5	21					0	0	0.047766	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336934	25336934	+	RNA	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:25336934G>T	ENST00000546682.1	+	0	969				SNORD116-23_ENST00000384645.1_RNA|SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						ACTGTGCATGGATCGATGATG	0.473000													32	103					7.11191e-15	9.32317e-15	0.054565	1	0
CLDN2	9075	broad.mit.edu	37	X	106171474	106171474	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:106171474C>A	ENST00000541806.1	+	2	535	c.16C>A	c.(16-18)Ctc>Atc	p.L6I	CLDN2_ENST00000336803.1_Missense_Mutation_p.L6I|CLDN2_ENST00000540876.1_Missense_Mutation_p.L6I	NM_001171092.1	NP_001164563.1	P57739	CLD2_HUMAN	claudin 2	6					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						CTCTCTTGGCCTCCAACTTGT	0.552000													29	50					1.22384e-17	1.64585e-17	0.054565	1	0
RBM10	8241	broad.mit.edu	37	X	47039816	47039816	+	Splice_Site	SNP	A	A	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:47039816A>T	ENST00000377604.3	+	12	1902		c.e12-1		RBM10_ENST00000468791.1_Intron|RBM10_ENST00000345781.6_Splice_Site|RBM10_ENST00000329236.7_Splice_Site	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10						mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CATCCTCCTCAGGGACATGGC	0.632000													7	37					0	0	0.047766	0	0
PVRL4	81607	broad.mit.edu	37	1	161049727	161049727	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:161049727G>A	ENST00000368012.3	-	2	394	c.92C>T	c.(91-93)gCg>gTg	p.A31V		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	31					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CAGCTCACCCGCGGGGCACCG	0.622000													27	118					0	0	0.064281	0	0
DRD5	1816	broad.mit.edu	37	4	9785025	9785025	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:9785025G>T	ENST00000304374.2	+	1	1768	c.1372G>T	c.(1372-1374)Gac>Tac	p.D458Y		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	458					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTGGGAGCTGGACTGCGAGGG	0.507000													21	65					2.48779e-11	3.05587e-11	0.108266	1	0
DFNA5	1687	broad.mit.edu	37	7	24784262	24784262	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr7:24784262C>T	ENST00000342947.3	-	3	748	c.323G>A	c.(322-324)cGc>cAc	p.R108H	DFNA5_ENST00000409775.3_Missense_Mutation_p.R108H|DFNA5_ENST00000419307.1_5'UTR|DFNA5_ENST00000409970.1_5'UTR|DFNA5_ENST00000545231.1_5'UTR	NM_004403.2	NP_004394.1	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5	108					sensory perception of sound					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)|stomach(1)	19						GCTCTCTACGCGGCTGCTGCC	0.552000													14	53					0	0	0.033300	0	0
THUMPD1	55623	broad.mit.edu	37	16	20748389	20748389	+	Missense_Mutation	SNP	G	G	A	rs139713563	byFrequency	TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr16:20748389G>A	ENST00000381337.2	-	4	1219	c.875C>T	c.(874-876)gCg>gTg	p.A292V	THUMPD1_ENST00000396083.2_Missense_Mutation_p.A292V|THUMPD1_ENST00000431224.2_Missense_Mutation_p.A378V	NM_017736.3	NP_060206.2	Q9NXG2	THUM1_HUMAN	THUMP domain containing 1	292								p.A292V(1)		NS(2)|large_intestine(2)|lung(6)|pancreas(1)|urinary_tract(1)	12						TGATTTGTCCGCAGATTCCAG	0.448000													22	76					0	0	0.055883	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	27					1.12685e-05	1.27383e-05	0.047766	1	0
CCIN	881	broad.mit.edu	37	9	36170349	36170349	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:36170349C>T	ENST00000335119.2	+	1	961	c.850C>T	c.(850-852)Ctc>Ttc	p.L284F		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	284					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			CGTGGTCATCCTCGGTGGCCA	0.572000													31	56					0	0	0.080422	0	0
ZHX2	22882	broad.mit.edu	37	8	123964468	123964468	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:123964468G>A	ENST00000314393.4	+	3	1553	c.718G>A	c.(718-720)Gga>Aga	p.G240R		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	240	Required for homodimerization.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AGACACATTAGGACACGTCAT	0.562000													44	179					0	0	0.048971	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218146	44218146	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr6:44218146A>T	ENST00000371554.1	+	6	981	c.767A>T	c.(766-768)gAt>gTt	p.D256V	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.D256V|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.D256V			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	256					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			gtgggttcagatgaggaggat	0.388000													12	11					0	0	0.080935	0	0
HUWE1	10075	broad.mit.edu	37	X	53578301	53578301	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:53578301C>A	ENST00000342160.3	-	63	9479	c.9022G>T	c.(9022-9024)Gtg>Ttg	p.V3008L	HUWE1_ENST00000262854.6_Missense_Mutation_p.V3008L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3008					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TTCCCCACCACTGCAGGCGCT	0.597000													9	24					2.17888e-05	2.41067e-05	0.058154	1	0
PCDH18	54510	broad.mit.edu	37	4	138451510	138451510	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:138451510C>A	ENST00000344876.4	-	1	2119	c.1733G>T	c.(1732-1734)gGg>gTg	p.G578V	PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.G358V|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.G578V	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	578					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CAATGCAGGCCCTATAACCAC	0.463000													63	156					3.41413e-29	5.17092e-29	0.048971	1	0
STAG2	10735	broad.mit.edu	37	X	123224763	123224763	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:123224763A>G	ENST00000218089.9	+	32	4037	c.3527A>G	c.(3526-3528)gAg>gGg	p.E1176G	STAG2_ENST00000371144.3_Intron|STAG2_ENST00000371145.3_Missense_Mutation_p.E1176G|STAG2_ENST00000371157.3_Intron|STAG2_ENST00000371160.1_Intron|STAG2_ENST00000354548.5_Intron|STAG2_ENST00000469481.1_Intron	NM_001042749.1	NP_001036214.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	1156					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						CAACAGCAGGAGAGAGCAGCA	0.403000													15	46					0	0	0.033300	0	0
COL6A6	131873	broad.mit.edu	37	3	130329537	130329537	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:130329537G>A	ENST00000358511.6	+	22	4828	c.4797G>A	c.(4795-4797)gtG>gtA	p.V1599V	COL6A6_ENST00000453409.2_Silent_p.V1599V	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1599	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AAGGAGGTGTGGGAAGTAAAG	0.388000													3	5					0	0	0.004672	0	0
TRPC6	7225	broad.mit.edu	37	11	101375285	101375285	+	Silent	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:101375285A>G	ENST00000344327.3	-	2	839	c.415T>C	c.(415-417)Ttg>Ctg	p.L139L	TRPC6_ENST00000360497.4_Silent_p.L139L|TRPC6_ENST00000532133.1_Silent_p.L139L|TRPC6_ENST00000348423.4_Silent_p.L139L	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	139					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GCCACTGCCAACTGTAGGGCA	0.448000													24	58					0	0	0.091800	0	0
SYT10	341359	broad.mit.edu	37	12	33579161	33579161	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:33579161G>C	ENST00000228567.3	-	2	717	c.421C>G	c.(421-423)Cca>Gca	p.P141A	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	141						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					ACTTCTGCTGGGATGTCAGGG	0.388000													32	160					0	0	0.086207	0	0
HRNR	388697	broad.mit.edu	37	1	152192190	152192190	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:152192190G>T	ENST00000368801.2	-	3	1990	c.1915C>A	c.(1915-1917)Cat>Aat	p.H639N	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	639					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGAGCCATGCTGACCGTGG	0.567000													79	620					1.30168e-36	2.05113e-36	0.048971	1	0
DMBT1	1755	broad.mit.edu	37	10	124351977	124351977	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:124351977G>C	ENST00000338354.3	+	20	2472	c.2366G>C	c.(2365-2367)gGc>gCc	p.G789A	DMBT1_ENST00000368955.3_Missense_Mutation_p.G779A|DMBT1_ENST00000368909.3_Missense_Mutation_p.G789A|DMBT1_ENST00000344338.3_Missense_Mutation_p.G779A|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000359586.6_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	789	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCCCGGTTTGGCCAGGGCTCA	0.607000													62	181					0	0	0.048971	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72953662	72953662	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:72953662C>T	ENST00000421285.3	+	8	622	c.622C>T	c.(622-624)Cgg>Tgg	p.R208W		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	208										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						CATAAAGGAGCGGGCGCTGCT	0.592000													19	149					0	0	0.037714	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999395	27999395	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:27999395C>A	ENST00000441525.1	-	1	171	c.57G>T	c.(55-57)ctG>ctT	p.L19L		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	19										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						GGCTGCTGAACAGGCTTTCAG	0.562000													11	46					3.27435e-08	3.89923e-08	0.020292	1	0
KDR	3791	broad.mit.edu	37	4	55958874	55958874	+	Silent	SNP	T	T	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:55958874T>C	ENST00000263923.4	-	22	3274	c.2979A>G	c.(2977-2979)gaA>gaG	p.E993E		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	993	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TATACAGATCTTCAGGAGCTG	0.433000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			16	35					0	0	0.033300	0	0
PTRF	284119	broad.mit.edu	37	17	40557198	40557198	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:40557198C>A	ENST00000357037.5	-	2	1099	c.680G>T	c.(679-681)cGg>cTg	p.R227L		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	227					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		GTCCACGCGCCGCAGGCCGCT	0.622000													26	83					3.73148e-12	4.65688e-12	0.034045	1	0
MCF2L2	23101	broad.mit.edu	37	3	182994678	182994678	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:182994678C>T	ENST00000328913.3	-	15	2141	c.1844G>A	c.(1843-1845)gGa>gAa	p.G615E	MCF2L2_ENST00000447025.2_Missense_Mutation_p.G615E|MCF2L2_ENST00000414362.2_Missense_Mutation_p.G615E|MCF2L2_ENST00000473233.1_Missense_Mutation_p.G615E	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	615					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGAAAGGTCTCCGAGCCTGGC	0.547000													3	18					0	0	0.004672	0	0
DST	667	broad.mit.edu	37	6	56510705	56510705	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr6:56510705G>A	ENST00000370754.5	-	14	1637	c.1638C>T	c.(1636-1638)gcC>gcT	p.A546A	DST_ENST00000421834.2_Silent_p.A368A|DST_ENST00000370769.4_Silent_p.A368A|DST_ENST00000312431.6_Silent_p.A368A|DST_ENST00000361203.3_Silent_p.A368A|DST_ENST00000370788.2_Silent_p.A368A			Q03001	DYST_HUMAN	dystonin	368					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTCTAGCATGGCAATAATGA	0.438000													50	76					0	0	0.048971	0	0
PAX6	5080	broad.mit.edu	37	11	31812372	31812372	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:31812372T>A	ENST00000419022.1	-	13	1579	c.1111A>T	c.(1111-1113)Atg>Ttg	p.M371L	PAX6_ENST00000379107.2_Missense_Mutation_p.M371L|PAX6_ENST00000241001.8_Missense_Mutation_p.M357L|PAX6_ENST00000379111.2_Missense_Mutation_p.M357L|PAX6_ENST00000379123.5_Missense_Mutation_p.M357L|PAX6_ENST00000379132.3_Missense_Mutation_p.M357L|PAX6_ENST00000379129.2_Missense_Mutation_p.M371L|PAX6_ENST00000379115.4_Missense_Mutation_p.M371L	NM_001127612.1|NM_001258462.1|NM_001258463.1	NP_001121084.1|NP_001245391.1|NP_001245392.1	P26367	PAX6_HUMAN	paired box 6	357	Pro/Ser/Thr-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)	35	Lung SC(675;0.225)					GTGGGCAGCATGCAGGAGTAT	0.587000									Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation				14	52					0	0	0.033300	0	0
POTEH	23784	broad.mit.edu	37	22	16267070	16267070	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:16267070C>A	ENST00000343518.6	-	9	1430	c.1379G>T	c.(1378-1380)gGa>gTa	p.G460V		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	460										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ATGAGTACTTCCGTGCTTCTT	0.358000													24	347					1.17478e-05	1.31846e-05	0.059317	1	0
IL4R	3566	broad.mit.edu	37	16	27353517	27353517	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr16:27353517A>G	ENST00000395762.2	+	4	405	c.146A>G	c.(145-147)aAt>aGt	p.N49S	IL4R_ENST00000543915.2_Missense_Mutation_p.N49S|IL4R_ENST00000449195.1_Missense_Mutation_p.N49S|IL4R_ENST00000380922.3_Missense_Mutation_p.N34S|IL4R_ENST00000170630.2_Missense_Mutation_p.N49S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	49					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						TGGAAGATGAATGGTCCCACC	0.572000													14	148					0	0	0.038395	0	0
WWC3	55841	broad.mit.edu	37	X	10094316	10094316	+	Silent	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:10094316A>G	ENST00000380861.4	+	15	2467	c.2076A>G	c.(2074-2076)tcA>tcG	p.S692S	WWC3_ENST00000454666.1_Silent_p.S692S	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	692	C2.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						ACGTGTGTTCAGTGACTCCGC	0.547000													26	89					0	0	0.064281	0	0
OR2G6	391211	broad.mit.edu	37	1	248685488	248685488	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:248685488G>T	ENST00000343414.4	+	1	573	c.541G>T	c.(541-543)Gtg>Ttg	p.V181L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTCTGTGAGGTGCCAGTGCT	0.517000													46	51					8.86878e-18	1.20307e-17	0.048971	1	0
NUP214	8021	broad.mit.edu	37	9	134107673	134107673	+	Missense_Mutation	SNP	T	T	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:134107673T>G	ENST00000359428.5	+	35	6361	c.6217T>G	c.(6217-6219)Ttc>Gtc	p.F2073V	NUP214_ENST00000411637.2_Missense_Mutation_p.F2063V|NUP214_ENST00000451030.1_Missense_Mutation_p.F2074V|NUP214_ENST00000483497.2_Missense_Mutation_p.F899V			P35658	NU214_HUMAN	nucleoporin 214kDa	2073	11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CTTTTCAGGGTTCAGCTTTGG	0.433000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								16	69					0	0	0.055883	0	0
AATK	9625	broad.mit.edu	37	17	79094976	79094976	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:79094976G>T	ENST00000326724.4	-	11	2784	c.2760C>A	c.(2758-2760)ttC>ttA	p.F920L	AATK_ENST00000417379.1_Missense_Mutation_p.F817L	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	920						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCGACGGGCTGAAGACCTCAT	0.637000													5	9					0.000602214	0.000634767	0.014758	1	0
DRP2	1821	broad.mit.edu	37	X	100509869	100509869	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:100509869G>T	ENST00000395209.3	+	19	2663	c.2136G>T	c.(2134-2136)tgG>tgT	p.W712C	DRP2_ENST00000538510.1_Missense_Mutation_p.W712C|DRP2_ENST00000541709.1_Missense_Mutation_p.W634C|DRP2_ENST00000402866.1_Missense_Mutation_p.W712C	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	712					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						CCCCGATGTGGCCACACGCCG	0.572000													17	173					2.37509e-13	3.037e-13	0.055883	1	0
OAS2	4939	broad.mit.edu	37	12	113435349	113435349	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:113435349C>A	ENST00000392583.2	+	4	859	c.652C>A	c.(652-654)Ccc>Acc	p.P218T	OAS2_ENST00000342315.4_Missense_Mutation_p.P218T|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	218	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CAAGGATTTACCCTCGCTGTC	0.488000													20	47					2.44723e-14	3.15511e-14	0.099896	1	0
DST	667	broad.mit.edu	37	6	56347530	56347530	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr6:56347530C>T	ENST00000370754.5	-	89	21259	c.21260G>A	c.(21259-21261)tGt>tAt	p.C7087Y	DST_ENST00000421834.2_Missense_Mutation_p.C4821Y|DST_ENST00000244364.6_Missense_Mutation_p.C4495Y|DST_ENST00000446842.2_Missense_Mutation_p.C6583Y|DST_ENST00000370769.4_Missense_Mutation_p.C6909Y|DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Missense_Mutation_p.C6798Y|DST_ENST00000370788.2_Missense_Mutation_p.C4712Y			Q03001	DYST_HUMAN	dystonin	6907					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGAAAGTGCACACACGGTCTC	0.498000													14	116					0	0	0.024245	0	0
ETV6	2120	broad.mit.edu	37	12	12022897	12022897	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:12022897A>G	ENST00000396373.4	+	5	1277	c.1003A>G	c.(1003-1005)Ata>Gta	p.I335V		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	335						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CATTGGGAGAATAGCAGGTGA	0.572000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								25	58					0	0	0.099896	0	0
POGZ	23126	broad.mit.edu	37	1	151378624	151378624	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:151378624C>A	ENST00000271715.2	-	19	3201	c.2887G>T	c.(2887-2889)Ggt>Tgt	p.G963C	POGZ_ENST00000540984.1_Missense_Mutation_p.G325C|POGZ_ENST00000361398.3_Missense_Mutation_p.G910C|POGZ_ENST00000531094.1_Missense_Mutation_p.G901C|POGZ_ENST00000392723.1_Missense_Mutation_p.G910C|POGZ_ENST00000491586.1_Missense_Mutation_p.G919C|POGZ_ENST00000409503.1_Missense_Mutation_p.G954C|POGZ_ENST00000368863.2_Missense_Mutation_p.G868C	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	963					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCACCACTACCACCACCACCT	0.512000													28	197					2.47316e-13	3.13669e-13	0.059317	1	0
FITM2	128486	broad.mit.edu	37	20	42935469	42935469	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr20:42935469C>A	ENST00000396825.3	-	2	605	c.585G>T	c.(583-585)ctG>ctT	p.L195L		NM_001080472.1	NP_001073941.1	Q8N6M3	FITM2_HUMAN	fat storage-inducing transmembrane protein 2	195					cellular triglyceride homeostasis|lipid particle organization|positive regulation of sequestering of triglyceride|regulation of triglyceride biosynthetic process	integral to endoplasmic reticulum membrane				endometrium(2)|lung(2)|skin(2)	6						TCAGAATGCCCAGGGCCACAA	0.522000													12	47					0.00010058	0.000108962	0.093190	1	0
ZMAT4	79698	broad.mit.edu	37	8	40438694	40438694	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:40438694G>T	ENST00000297737.6	-	6	810	c.664C>A	c.(664-666)Cac>Aac	p.H222N	ZMAT4_ENST00000315769.7_Missense_Mutation_p.H146N	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	222						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TTGGTCTGGTGTTTAGATCCT	0.388000													27	42					8.88839e-20	1.22707e-19	0.045705	1	0
HUWE1	10075	broad.mit.edu	37	X	53578038	53578038	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:53578038C>A	ENST00000342160.3	-	64	9666	c.9209G>T	c.(9208-9210)cGc>cTc	p.R3070L	HUWE1_ENST00000262854.6_Missense_Mutation_p.R3070L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3070					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GACACTACGGCGCAGGTCTGA	0.572000													28	90					1.56442e-22	2.19864e-22	0.050027	1	0
HOOK2	29911	broad.mit.edu	37	19	12874498	12874498	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:12874498C>A	ENST00000264827.5	-	20	2086	c.1916G>T	c.(1915-1917)cGc>cTc	p.R639L	HOOK2_ENST00000397668.3_Missense_Mutation_p.R641L	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	641	Required for localization to the centrosome and induction of aggresome formation.|Sufficient for interaction with CEP110.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						GTGTCGGATGCGGACATCCCG	0.587000													28	47					6.00712e-18	8.22027e-18	0.050027	1	0
TNRC6A	27327	broad.mit.edu	37	16	24834870	24834870	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr16:24834870C>T	ENST00000395799.3	+	25	5760	c.5631C>T	c.(5629-5631)tcC>tcT	p.S1877S	TNRC6A_ENST00000315183.7_Silent_p.S1828S|TNRC6A_ENST00000432286.2_Silent_p.S355S	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1877	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CTCTCGGGTCCAGCCAGAGCC	0.567000													53	131					0	0	0.048971	0	0
SEC23IP	11196	broad.mit.edu	37	10	121662475	121662475	+	Silent	SNP	T	T	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:121662475T>G	ENST00000369075.3	+	3	933	c.861T>G	c.(859-861)ccT>ccG	p.P287P	SEC23IP_ENST00000543134.1_Silent_p.P76P	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	287	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TGTGGATGCCTTTTAGTGTGT	0.378000													13	45					0	0	0.043863	0	0
CACNA1I	8911	broad.mit.edu	37	22	40066162	40066162	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:40066162G>A	ENST00000336649.4	+	28	4332	c.4332G>A	c.(4330-4332)cgG>cgA	p.R1444R	CACNA1I_ENST00000400164.3_Silent_p.R1403R|CACNA1I_ENST00000404898.1_Silent_p.R1403R|CACNA1I_ENST00000402142.3_Silent_p.R1438R|CACNA1I_ENST00000401624.1_Silent_p.R1438R|CACNA1I_ENST00000407673.1_Silent_p.R1403R			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1438					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACAAGTGCCGGCAGCACCAGG	0.612000													4	123					0	0	0.014758	0	0
KEAP1	9817	broad.mit.edu	37	19	10602925	10602925	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:10602925T>A	ENST00000171111.5	-	3	1200	c.653A>T	c.(652-654)gAg>gTg	p.E218V	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.E218V	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	218	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GAAGAACTCCTCTTGCTTGGC	0.607000													28	28					0	0	0.041601	0	0
ABL1	25	broad.mit.edu	37	9	133760830	133760830	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:133760830C>T	ENST00000318560.5	+	11	3534	c.3153C>T	c.(3151-3153)gcC>gcT	p.A1051A		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	1051	F-actin-binding.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	AGCAGATGGCCAGCCACAGCG	0.607000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								8	63					0	0	0.047766	0	0
CCDC51	79714	broad.mit.edu	37	3	48475178	48475178	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:48475178C>G	ENST00000395694.2	-	3	501	c.416G>C	c.(415-417)cGt>cCt	p.R139P	CCDC51_ENST00000412398.2_Missense_Mutation_p.R30P|CCDC51_ENST00000442740.1_Missense_Mutation_p.R30P|CCDC51_ENST00000395696.1_Missense_Mutation_p.R139P|CCDC51_ENST00000447018.1_Missense_Mutation_p.R30P	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	139						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCTGGAGACACGGTCCAAGCG	0.597000													40	106					0	0	0.098360	0	0
TECTA	7007	broad.mit.edu	37	11	120989283	120989283	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:120989283G>A	ENST00000392793.1	+	7	1330	c.1059G>A	c.(1057-1059)ttG>ttA	p.L353L	TECTA_ENST00000264037.2_Silent_p.L353L			O75443	TECTA_HUMAN	tectorin alpha	353	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GACAGTGTTTGCAGACTTCCA	0.562000													7	126					0	0	0.058154	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256365	69256365	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr14:69256365T>A	ENST00000439696.2	-	2	1203	c.902A>T	c.(901-903)gAc>gTc	p.D301V	ZFP36L1_ENST00000336440.3_Missense_Mutation_p.D301V|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	301					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCCTCCTGGTCCGAGAGAGA	0.632000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	112					0	0	0.048971	0	0
SLC13A2	9058	broad.mit.edu	37	17	26817852	26817852	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:26817852G>A	ENST00000444914.3	+	4	1069	c.649G>A	c.(649-651)Gtc>Atc	p.V217I	SLC13A2_ENST00000545060.1_Missense_Mutation_p.V125I|SLC13A2_ENST00000537681.1_Missense_Mutation_p.V97I|SLC13A2_ENST00000314669.5_Missense_Mutation_p.V168I	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	168						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CAGCAGCAACGTCGAGGAGGG	0.597000													19	41					0	0	0.043863	0	0
DSCAML1	57453	broad.mit.edu	37	11	117374709	117374709	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:117374709G>T	ENST00000321322.6	-	11	2391	c.2390C>A	c.(2389-2391)cCt>cAt	p.P797H	DSCAML1_ENST00000527706.1_Missense_Mutation_p.P527H	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	737	Ig-like C2-type 9.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GAGGGGCACAGGGTGGTACTG	0.642000													47	122					3.00063e-23	4.37475e-23	0.048971	1	0
TPO	7173	broad.mit.edu	37	2	1481007	1481007	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr2:1481007C>G	ENST00000345913.4	+	8	1060	c.969C>G	c.(967-969)ttC>ttG	p.F323L	TPO_ENST00000497517.2_Intron|TPO_ENST00000382198.1_Intron|TPO_ENST00000349624.3_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.F323L|TPO_ENST00000382201.3_Missense_Mutation_p.F323L|TPO_ENST00000337415.3_Missense_Mutation_p.F323L|TPO_ENST00000329066.4_Missense_Mutation_p.F323L	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	323					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGACCTCGTTCCTGGACGCGT	0.697000													7	13					0	0	0.047766	0	0
SNHG14	104472715	broad.mit.edu	37	15	25458874	25458874	+	RNA	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:25458874C>A	ENST00000424208.1	+	0	2694				SNORD115-24_ENST00000363528.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TACGCTGAGGCCCAGCCTAGT	0.502000													64	173					4.03997e-35	6.23996e-35	0.048971	1	0
POLA1	5422	broad.mit.edu	37	X	24753519	24753519	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:24753519G>T	ENST00000379068.3	+	18	1880	c.1837G>T	c.(1837-1839)Gtg>Ttg	p.V613L	POLA1_ENST00000379059.3_Missense_Mutation_p.V607L			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	607					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	CTAACAGAATGTGAAGGTTGA	0.388000													29	68					6.05902e-23	8.75192e-23	0.064281	1	0
USH2A	7399	broad.mit.edu	37	1	216144109	216144109	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:216144109G>A	ENST00000366943.2	-	36	7201	c.6815C>T	c.(6814-6816)aCg>aTg	p.T2272M	USH2A_ENST00000307340.3_Missense_Mutation_p.T2272M			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2272	Fibronectin type-III 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCATAACTCGTGATAACACC	0.373000										HNSCC(13;0.011)			22	172					0	0	0.108266	0	0
GABRA4	2557	broad.mit.edu	37	4	46967068	46967068	+	Silent	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:46967068G>C	ENST00000264318.3	-	8	2035	c.1053C>G	c.(1051-1053)gcC>gcG	p.A351A		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	351					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.A351A(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTTCCTTTTGGCTTTTTCCA	0.468000													14	46					0	0	0.033300	0	0
MBL2	4153	broad.mit.edu	37	10	54528269	54528269	+	Splice_Site	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:54528269C>T	ENST00000373968.3	-	4	439	c.373_splice	c.e4-1	p.W125_splice	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	125					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						AGAAGGTGAGCCCTAAAATGT	0.413000													14	58					0	0	0.080422	0	0
EBF2	64641	broad.mit.edu	37	8	25745399	25745399	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:25745399C>T	ENST00000520164.1	-	9	1378	c.841G>A	c.(841-843)Ggt>Agt	p.G281S	EBF2_ENST00000408929.3_Missense_Mutation_p.G133S|EBF2_ENST00000535548.1_Missense_Mutation_p.G12S	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	281	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		ACTTGGAGACCATCAAAGAAG	0.493000													3	68					0	0	0.014758	0	0
SMARCD1	6602	broad.mit.edu	37	12	50481255	50481255	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:50481255G>A	ENST00000394963.4	+	5	1039	c.641G>A	c.(640-642)cGg>cAg	p.R214Q	SMARCD1_ENST00000381513.4_Missense_Mutation_p.R214Q	NM_003076.4	NP_003067.3	Q96GM5	SMRD1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	214	Interaction with SMARCC1 and SMARCC2.|Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			NS(1)|breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	18						GTAGAAGGACGGCTCCTGGAG	0.532000													52	96					0	0	0.048971	0	0
SETBP1	26040	broad.mit.edu	37	18	42532001	42532001	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr18:42532001T>C	ENST00000282030.5	+	4	2992	c.2696T>C	c.(2695-2697)cTg>cCg	p.L899P		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	899						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TTCTGCTCCCTGGACAACCCG	0.557000									Schinzel-Giedion syndrome				14	22					0	0	0.105934	0	0
ATXN3L	92552	broad.mit.edu	37	X	13337381	13337381	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:13337381C>G	ENST00000380622.2	-	1	1137	c.673G>C	c.(673-675)Gat>Cat	p.D225H	GS1-600G8.3_ENST00000431486.1_RNA	NM_001135995.1	NP_001129467.1	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	225					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TCCTCCTCATCTTGGTCTGAT	0.383000													103	204					0	0	0.048971	0	0
RPRM	56475	broad.mit.edu	37	2	154335041	154335041	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr2:154335041G>T	ENST00000325926.3	-	1	281	c.39C>A	c.(37-39)ggC>ggA	p.G13G	AC012501.2_ENST00000424322.1_RNA	NM_019845.2	NP_062819.1	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependent G2 arrest mediator candidate	13					cell cycle arrest	cytoplasm|integral to membrane	protein binding			large_intestine(2)|lung(1)|prostate(1)	4						CCAGGAACAGGCCCGCCACGT	0.751000													7	10					1.12685e-05	1.27383e-05	0.047766	1	0
SEMG2	6407	broad.mit.edu	37	20	43850359	43850359	+	Missense_Mutation	SNP	A	A	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr20:43850359A>C	ENST00000372769.3	+	2	176	c.86A>C	c.(85-87)aAa>aCa	p.K29T		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	29					sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				GGTGGATCAAAAGGCCAATTG	0.403000													27	70					0	0	0.030593	0	0
ZNF195	7748	broad.mit.edu	37	11	3380510	3380510	+	Silent	SNP	T	T	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:3380510T>C	ENST00000354599.6	-	4	1616	c.1512A>G	c.(1510-1512)aaA>aaG	p.K504K	ZNF195_ENST00000005082.9_Silent_p.K553K|ZNF195_ENST00000528796.1_Intron|ZNF195_ENST00000343338.7_Silent_p.K508K|ZNF195_ENST00000429541.2_Silent_p.K508K|ZNF195_ENST00000399602.4_Silent_p.K576K|ZNF195_ENST00000526601.1_Silent_p.K557K	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGTTTCTCTCCAG	0.393000													4	120					0	0	0.009096	0	0
OR1S1	219959	broad.mit.edu	37	11	57982442	57982442	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:57982442C>G	ENST00000309433.6	+	1	226	c.226C>G	c.(226-228)Ctt>Gtt	p.L76V		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				GTATCTCTTCCTTGCCAATCT	0.443000													58	170					0	0	0.048971	0	0
SCYL3	57147	broad.mit.edu	37	1	169839455	169839455	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:169839455C>A	ENST00000367772.4	-	6	763	c.566G>T	c.(565-567)cGg>cTg	p.R189L	SCYL3_ENST00000470238.1_5'UTR|SCYL3_ENST00000367770.1_Missense_Mutation_p.R189L|SCYL3_ENST00000367771.5_Missense_Mutation_p.R189L	NM_181093.3	NP_851607.2	Q8IZE3	PACE1_HUMAN	SCY1-like 3 (S. cerevisiae)	189	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAAGGCATCCCGGGCATGTCC	0.398000													67	86					2.05912e-35	3.21223e-35	0.048971	1	0
C12orf52	84934	broad.mit.edu	37	12	113624562	113624562	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:113624562C>T	ENST00000548278.1	+	3	703	c.11C>T	c.(10-12)cCc>cTc	p.P4L	RP11-545P7.4_ENST00000552525.1_RNA|C12orf52_ENST00000549621.1_Missense_Mutation_p.P4L|C12orf52_ENST00000552495.1_Missense_Mutation_p.P28L	NM_032848.1	NP_116237.1	Q96K30	RITA_HUMAN	chromosome 12 open reading frame 52	4					negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding			large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	5						ATGAAGACCCCCGTGGAGCTG	0.647000													5	32					0	0	0.029380	0	0
POTEM	641455	broad.mit.edu	37	14	20019965	20019965	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr14:20019965G>T	ENST00000551509.1	-	1	307	c.256C>A	c.(256-258)Cac>Aac	p.H86N		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	86										endometrium(4)|kidney(1)|lung(4)	9						GAGTCGTCGTGGTCTCCAGAA	0.612000													41	640					8.73351e-45	1.40456e-44	0.048971	1	0
WWC3	55841	broad.mit.edu	37	X	10085253	10085253	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:10085253C>T	ENST00000380861.4	+	11	1545	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F	WWC3_ENST00000454666.1_Missense_Mutation_p.S385F	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	385	Ser-rich.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						AGCCGGGGCTCCCTGAGCTCG	0.657000													31	89					0	0	0.054565	0	0
TMEM102	284114	broad.mit.edu	37	17	7340297	7340297	+	Silent	SNP	C	C	T	rs111344839		TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:7340297C>T	ENST00000323206.1	+	3	1272	c.999C>T	c.(997-999)agC>agT	p.S333S	RP11-104H15.9_ENST00000570444.1_RNA|TMEM102_ENST00000396568.1_Silent_p.S333S|RP11-104H15.7_ENST00000575310.1_RNA	NM_178518.2	NP_848613.1	Q8N9M5	TM102_HUMAN	transmembrane protein 102	333					regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding			kidney(1)|lung(3)|skin(1)	5		Prostate(122;0.173)				GGGCTCGGAGCCACTCGTGGG	0.726000													12	20					0	0	0.020292	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605063	140605063	+	Silent	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:140605063G>C	ENST00000239449.4	+	1	1986	c.1986G>C	c.(1984-1986)ctG>ctC	p.L662L	PCDHB14_ENST00000515856.2_Silent_p.L509L	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		662	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGTGCTCCTGGTGGACGGCT	0.706000													35	77					0	0	0.074837	0	0
RNF26	79102	broad.mit.edu	37	11	119206355	119206355	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:119206355G>T	ENST00000311413.4	+	1	1119	c.523G>T	c.(523-525)Ggg>Tgg	p.G175W		NM_032015.4	NP_114404.1	Q9BY78	RNF26_HUMAN	ring finger protein 26	175	Leu-rich.						zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		TGCAGTGACCGGGCCTCTGTG	0.587000													14	47					9.16793e-09	1.10015e-08	0.033300	1	0
FBXO43	286151	broad.mit.edu	37	8	101152954	101152954	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:101152954G>C	ENST00000428847.2	-	2	1844	c.1528C>G	c.(1528-1530)Ctt>Gtt	p.L510V		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	510	F-box.				meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			ACCATAGCAAGAATATGCTTT	0.328000													25	99					0	0	0.091800	0	0
FAM179B	23116	broad.mit.edu	37	14	45433134	45433134	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr14:45433134G>C	ENST00000361462.2	+	1	1693	c.1510G>C	c.(1510-1512)Gag>Cag	p.E504Q	KLHL28_ENST00000553817.1_5'UTR|FAM179B_ENST00000382233.2_Missense_Mutation_p.E504Q|FAM179B_ENST00000361577.3_Missense_Mutation_p.E504Q			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	504							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CTATCCTAGTGAGGATTTTGA	0.473000													40	113					0	0	0.045515	0	0
CPT1A	1374	broad.mit.edu	37	11	68579920	68579920	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:68579920C>G	ENST00000265641.5	-	3	420	c.266G>C	c.(265-267)cGg>cCg	p.R89P	CPT1A_ENST00000376618.2_Missense_Mutation_p.R89P|CPT1A_ENST00000540367.1_Missense_Mutation_p.R89P|CPT1A_ENST00000539743.1_Missense_Mutation_p.R89P	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	89					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TTCCAGAGTCCGATTGATTTT	0.453000													28	86					0	0	0.086207	0	0
ATP2B2	491	broad.mit.edu	37	3	10413716	10413716	+	Missense_Mutation	SNP	T	T	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:10413716T>G	ENST00000397077.1	-	11	1876	c.1301A>C	c.(1300-1302)aAc>aCc	p.N434T	ATP2B2_ENST00000352432.4_Missense_Mutation_p.N479T|ATP2B2_ENST00000343816.4_Missense_Mutation_p.N465T|ATP2B2_ENST00000383800.4_Missense_Mutation_p.N434T|ATP2B2_ENST00000360273.2_Missense_Mutation_p.N479T			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	479					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GCGTACCAGGTTGTTGTCCTT	0.577000													17	78					0	0	0.043863	0	0
FGF4	2249	broad.mit.edu	37	11	69588224	69588224	+	Silent	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:69588224C>T	ENST00000168712.1	-	3	792	c.474G>A	c.(472-474)aaG>aaA	p.K158K	FGF4_ENST00000538040.1_5'UTR	NM_002007.2	NP_001998.1	P08620	FGF4_HUMAN	fibroblast growth factor 4	158					cell-cell signaling|chondroblast differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade	extracellular region	growth factor activity|heparin binding			lung(3)	3	Melanoma(5;1.89e-05)		LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)		Pentosan Polysulfate(DB00686)	GGAGAATCTCCTTGAACGTGC	0.572000													11	156					0	0	0.093190	0	0
RYR2	6262	broad.mit.edu	37	1	237823303	237823303	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:237823303T>A	ENST00000366574.2	+	55	8544	c.8227T>A	c.(8227-8229)Tat>Aat	p.Y2743N	RYR2_ENST00000542537.1_Missense_Mutation_p.Y2727N|RYR2_ENST00000360064.6_Missense_Mutation_p.Y2741N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2743	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGATGGATTTATGGAGAAAT	0.308000													17	27					0	0	0.076483	0	0
KRT10	3858	broad.mit.edu	37	17	38976885	38976885	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:38976885C>T	ENST00000269576.5	-	3	754	c.745G>A	c.(745-747)Gag>Aag	p.E249K	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	249	Coil 1B.|Gly-rich.|Rod.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				ATGTCAGCCTCCACGCTCTGG	0.507000													35	83					0	0	0.064281	0	0
CR1L	1379	broad.mit.edu	37	1	207868033	207868033	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:207868033C>T	ENST00000508064.2	+	5	859	c.799C>T	c.(799-801)Ccc>Tcc	p.P267S	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	267	Sushi 4.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CATGAAAGGGCCCTCCCATGT	0.498000													69	133					0	0	0.048971	0	0
TINAG	27283	broad.mit.edu	37	6	54191662	54191662	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr6:54191662G>A	ENST00000259782.4	+	4	668	c.572G>A	c.(571-573)cGc>cAc	p.R191H	TINAG_ENST00000370869.3_Missense_Mutation_p.R187H|TINAG_ENST00000370864.3_Missense_Mutation_p.R173H	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity	p.R191H(1)|p.R191L(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTAAATTTCGCCTTGGCACT	0.373000													40	114					0	0	0.048971	0	0
PCDH15	65217	broad.mit.edu	37	10	55566840	55566840	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:55566840G>T	ENST00000373965.2	-	36	4948	c.4554C>A	c.(4552-4554)acC>acA	p.T1518T	PCDH15_ENST00000414778.1_Silent_p.T1515T	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	581					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CAGTTGAGCTGGTTTCATACT	0.353000										HNSCC(58;0.16)			5	24					8.12818e-05	8.86711e-05	0.029380	1	0
KLHL38	340359	broad.mit.edu	37	8	124658139	124658139	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:124658139C>T	ENST00000325995.7	-	3	1609	c.1586G>A	c.(1585-1587)cGg>cAg	p.R529Q	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	529										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						GGTCAGCCGCCGCCCGCCCGT	0.582000													27	115					0	0	0.037714	0	0
SOX10	6663	broad.mit.edu	37	22	38374042	38374042	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:38374042G>T	ENST00000396884.2	-	3	811	c.529C>A	c.(529-531)Cgg>Agg	p.R177R	SOX10_ENST00000360880.2_Silent_p.R177R|POLR2F_ENST00000407936.1_Intron|POLR2F_ENST00000405557.1_Intron	NM_006941.3	NP_008872.1	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	177						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity	p.R177W(1)		NS(6)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|skin(2)	20	Melanoma(58;0.045)					TTCTTCCGCCGCCTGGGCTGG	0.667000													3	11					0.00909568	0.00921381	0.009096	1	0
OR4A5	81318	broad.mit.edu	37	11	51411684	51411684	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr11:51411684T>A	ENST00000319760.6	-	1	764	c.712A>T	c.(712-714)Agc>Tgc	p.S238C		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				CTGCCGGAGCTGCAGGTAGAC	0.403000													19	64					0	0	0.062417	0	0
OR2G3	81469	broad.mit.edu	37	1	247769715	247769715	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:247769715C>A	ENST00000320002.2	+	1	860	c.828C>A	c.(826-828)ctC>ctA	p.L276L	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTATCTCCCTCTTCTACACCA	0.438000													29	67					1.56442e-22	2.19864e-22	0.050027	1	0
FAM171A1	221061	broad.mit.edu	37	10	15255962	15255962	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:15255962G>A	ENST00000378116.4	-	8	1631	c.1625C>T	c.(1624-1626)tCg>tTg	p.S542L		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	542						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TACTGATCGCGACATCATACA	0.542000													6	222					0	0	0.038147	0	0
USP29	57663	broad.mit.edu	37	19	57641606	57641606	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:57641606G>T	ENST00000254181.4	+	4	2017	c.1563G>T	c.(1561-1563)ttG>ttT	p.L521F	USP29_ENST00000598197.1_Missense_Mutation_p.L521F	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	521					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGCTTGGTTGCTGGTGAAGA	0.403000													61	75					2.54232e-27	3.81347e-27	0.048971	1	0
SSTR3	6753	broad.mit.edu	37	22	37603252	37603252	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:37603252C>A	ENST00000328544.3	-	2	1124	c.591G>T	c.(589-591)gaG>gaT	p.E197D	SSTR3_ENST00000402501.1_Missense_Mutation_p.E197D	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	197					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CCGCCGCCGGCTCGGGCCACT	0.697000													3	14					6.4e-05	7.03099e-05	0.004672	1	0
IGLC3	3539	broad.mit.edu	37	22	23248770	23248770	+	RNA	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr22:23248770G>A	ENST00000390325.2	+	0	259																											AGCTACAGCTGCCAGGTCACG	0.577000													9	59					0	0	0.033300	0	0
SPRR3	6707	broad.mit.edu	37	1	152975887	152975887	+	Missense_Mutation	SNP	A	A	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:152975887A>C	ENST00000331860.3	+	3	541	c.391A>C	c.(391-393)Atc>Ctc	p.I131L	SPRR3_ENST00000295367.4_Missense_Mutation_p.I131L|SPRR3_ENST00000542696.1_Missense_Mutation_p.I123L	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	131	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCAGGTGCCATCAAAGTTCC	0.547000													7	35					0	0	0.038147	0	0
CYP20A1	57404	broad.mit.edu	37	2	204161566	204161566	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr2:204161566A>G	ENST00000356079.4	+	13	1447	c.1324A>G	c.(1324-1326)Aca>Gca	p.T442A	CYP20A1_ENST00000461371.1_3'UTR|CYP20A1_ENST00000429815.2_Missense_Mutation_p.T450A	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	442						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						GGTTATTGAAACAAAGTATGA	0.348000													28	43					0	0	0.041601	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475913	140475913	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr5:140475913C>A	ENST00000194155.4	+	1	1687	c.1539C>A	c.(1537-1539)ggC>ggA	p.G513G		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		513	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGACAACGGCCACCTGTTCG	0.706000													18	158					1.40151e-16	1.86868e-16	0.055883	1	0
SPATA31D5P	347127	broad.mit.edu	37	9	84533021	84533021	+	RNA	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:84533021C>A	ENST00000527857.1	+	0	3043					NR_026851.1																						GGCAGGGGACCCTGAGAAGAC	0.468000													7	43					0.0581538	0.058529	0.058154	1	0
AMMECR1	9949	broad.mit.edu	37	X	109561127	109561127	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:109561127C>A	ENST00000262844.5	-	1	340	c.173G>T	c.(172-174)gGt>gTt	p.G58V	AMMECR1_ENST00000372057.1_Intron|AMMECR1_ENST00000372059.2_Missense_Mutation_p.G58V	NM_015365.2	NP_056180.1	Q9Y4X0	AMER1_HUMAN	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	58	Gly/Ser-rich.									large_intestine(1)|lung(4)|ovary(1)|stomach(1)	7						TCCGGTTAGACCTCCCAGCCC	0.736000													6	14					0.00621372	0.00633555	0.058154	1	0
SIGLECL1	284369	broad.mit.edu	37	19	51768793	51768793	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:51768793G>A	ENST00000316401.7	+	3	575	c.194G>A	c.(193-195)tGg>tAg	p.W65*	SIGLECL1_ENST00000597824.1_Intron|CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000593968.1_Intron	NM_173635.1	NP_775906.1			SIGLEC family like 1																		CTTGGCCCCTGGGCTAACAGC	0.557000													22	25					0	0	0.076483	0	0
TACC3	10460	broad.mit.edu	37	4	1746481	1746481	+	Silent	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:1746481G>A	ENST00000313288.4	+	15	2479	c.2373G>A	c.(2371-2373)gcG>gcA	p.A791A		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	791						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AGGCCCAGGCGGAAGCGTTGG	0.672000													3	26					0	0	0.009096	0	0
SHOX	6473	broad.mit.edu	37	X	595519	595519	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:595519G>T	ENST00000381578.1	+	3	1135	c.444G>T	c.(442-444)gaG>gaT	p.E148D	SHOX_ENST00000334060.3_Missense_Mutation_p.E148D|SHOX_ENST00000554971.1_Missense_Mutation_p.E148D|SHOX_ENST00000381575.1_Missense_Mutation_p.E148D	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	148					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCATGCGCGAGGAGCTCAGCC	0.701000													2	3					0.004672	0.00479495	0.004672	1	0
HPSE2	60495	broad.mit.edu	37	10	100503793	100503793	+	Missense_Mutation	SNP	A	A	G	rs147866530	byFrequency	TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:100503793A>G	ENST00000370552.3	-	4	690	c.631T>C	c.(631-633)Tat>Cat	p.Y211H	HPSE2_ENST00000370549.1_Intron|HPSE2_ENST00000404542.1_Intron|HPSE2_ENST00000370546.1_Missense_Mutation_p.Y211H	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	211					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCAAAGTTATAAAGTTTGTCT	0.408000													11	24					0	0	0.024245	0	0
PLCB1	23236	broad.mit.edu	37	20	8709754	8709754	+	Silent	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr20:8709754C>A	ENST00000378641.3	+	18	2296	c.1821C>A	c.(1819-1821)tcC>tcA	p.S607S	PLCB1_ENST00000338037.6_Silent_p.S607S|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Silent_p.S607S	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	607	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TGGATTCATCCAACTATATGC	0.378000													43	58					1.81118e-26	2.6909e-26	0.048971	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	61					0	0	0.009096	0	0
TMEM132B	114795	broad.mit.edu	37	12	126135237	126135237	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:126135237G>A	ENST00000299308.3	+	7	1645	c.1637G>A	c.(1636-1638)cGg>cAg	p.R546Q	TMEM132B_ENST00000535886.1_Missense_Mutation_p.R58Q	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	546						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGGCCTACCCGGGAAAGCGAT	0.532000													14	39					0	0	0.038395	0	0
SGSH	6448	broad.mit.edu	37	17	78185956	78185956	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:78185956G>A	ENST00000326317.6	-	7	949	c.863C>T	c.(862-864)cCg>cTg	p.P288L	SGSH_ENST00000534910.1_Missense_Mutation_p.P85L|SGSH_ENST00000570923.1_3'UTR	NM_000199.3	NP_000190.1	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase	288			P -> S (in MPS3A).		proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity	p.P288L(1)		central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCAGTGCCCGGCCAGTACAG	0.617000													22	43					0	0	0.099896	0	0
BBS9	27241	broad.mit.edu	37	7	33380516	33380516	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr7:33380516G>T	ENST00000242067.6	+	11	1727	c.1206G>T	c.(1204-1206)tgG>tgT	p.W402C	BBS9_ENST00000355070.2_Missense_Mutation_p.W402C|BBS9_ENST00000396127.2_Missense_Mutation_p.W402C|BBS9_ENST00000354265.4_Missense_Mutation_p.W402C|BBS9_ENST00000350941.3_Missense_Mutation_p.W402C	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	402					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			CAGGTGTTTGGCCCATGACTG	0.308000									Bardet-Biedl syndrome				12	62					4.93089e-13	6.20338e-13	0.020292	1	0
CXADRP3	440224	broad.mit.edu	37	18	14478283	14478283	+	RNA	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr18:14478283G>T	ENST00000581457.1	-	0	1625					NR_024076.1																						TGAGGAGTGCGTTCAAAGTCT	0.483000													10	41					0.000673444	0.000705082	0.069234	1	0
RGMA	56963	broad.mit.edu	37	15	93595608	93595608	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:93595608C>A	ENST00000329082.7	-	3	531	c.260G>T	c.(259-261)cGg>cTg	p.R87L	RGMA_ENST00000557301.1_Missense_Mutation_p.R95L|RGMA_ENST00000555584.1_5'UTR|RGMA_ENST00000557420.1_Intron|RGMA_ENST00000556087.1_Missense_Mutation_p.R71L|RGMA_ENST00000556658.1_5'UTR|RGMA_ENST00000543599.1_Missense_Mutation_p.R71L|RGMA_ENST00000542321.2_Missense_Mutation_p.R71L|RGMA_ENST00000538818.1_5'UTR|RGMA_ENST00000425933.2_Missense_Mutation_p.R71L	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	87					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GGCCGTCCGCCGCGTGCACAG	0.677000													8	16					1.12685e-05	1.27383e-05	0.047766	1	0
GABRA4	2557	broad.mit.edu	37	4	46967069	46967069	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:46967069G>C	ENST00000264318.3	-	8	2034	c.1052C>G	c.(1051-1053)gCc>gGc	p.A351G		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	351					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTTCCTTTTGGCTTTTTCCAT	0.468000													16	44					0	0	0.038395	0	0
PHEX	5251	broad.mit.edu	37	X	22132589	22132589	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:22132589C>T	ENST00000379374.4	+	11	1752	c.1187C>T	c.(1186-1188)aCc>aTc	p.T396I	PHEX_ENST00000418858.3_Missense_Mutation_p.T99I|PHEX_ENST00000537599.1_Missense_Mutation_p.T396I|PHEX_ENST00000535894.1_Missense_Mutation_p.T299I	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	396					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						ATCCAGGGGACCACAACTTTG	0.393000													41	123					0	0	0.048971	0	0
HUWE1	10075	broad.mit.edu	37	X	53611279	53611279	+	Silent	SNP	G	G	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chrX:53611279G>T	ENST00000342160.3	-	40	5485	c.5028C>A	c.(5026-5028)cgC>cgA	p.R1676R	HUWE1_ENST00000218328.8_Intron|HUWE1_ENST00000262854.6_Silent_p.R1676R			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1676	WWE.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GCATCACAGGGCGTCGGTTCC	0.433000													12	29					7.03913e-09	8.51243e-09	0.093190	1	0
EBF3	253738	broad.mit.edu	37	10	131665437	131665437	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:131665437C>A	ENST00000368648.3	-	10	1052	c.980G>T	c.(979-981)tGc>tTc	p.C327F	EBF3_ENST00000355311.5_Missense_Mutation_p.C336F	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	336	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AGCACCTTTGCAGAACTGCTT	0.587000													12	30					7.93312e-07	9.23557e-07	0.020292	1	0
SCN11A	11280	broad.mit.edu	37	3	38913746	38913746	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr3:38913746A>G	ENST00000302328.3	-	20	3631	c.3433T>C	c.(3433-3435)Tcc>Ccc	p.S1145P	SCN11A_ENST00000456224.3_Missense_Mutation_p.S1107P|SCN11A_ENST00000444237.2_Missense_Mutation_p.S1145P|SCN11A_ENST00000450244.1_Missense_Mutation_p.S1145P	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1145					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GTCCGGAAGGACTTCAATTCC	0.478000													5	124					0	0	0.029380	0	0
EPHX1	2052	broad.mit.edu	37	1	226026384	226026384	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr1:226026384delC	ENST00000366837.4	+	4	590	c.394delC	c.(394-396)ccfs	p.P133fs	EPHX1_ENST00000272167.5_Frame_Shift_Del_p.P133fs	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	133					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					CCACGTGAAGCCCCCCCAGCT	0.627													7	458	---	---	---	---					
LOC100506797	100506797	broad.mit.edu	37	2	118943143	118943143	+	RNA	DEL	A	A	-	rs70949917	by1000genomes	TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr2:118943143delA	ENST00000414886.1	-	0	156																											acggcgggggaggggggagga	0.572													2	4	---	---	---	---					
CCDC96	257236	broad.mit.edu	37	4	7044507	7044509	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:7044507_7044509delCTC	ENST00000310085.4	-	1	219_221	c.157_159delGAG	c.(157-159)del	p.E53del	RP11-367J11.2_ENST00000500031.1_RNA	NM_153376.2	NP_699207.1	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	53	Glu-rich.									endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11						AAGCCGCTTGCTCCTCCTCCTCC	0.729													3	6	---	---	---	---					
CNGA1	1259	broad.mit.edu	37	4	47939653	47939654	+	Frame_Shift_Ins	INS	-	-	T			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr4:47939653_47939654insT	ENST00000402813.3	-	10	1206_1207	c.1064_1065insA	c.(1063-1065)cagfs	p.Q355fs	CNGA1_ENST00000544810.1_Frame_Shift_Ins_p.Q286fs|CNGA1_ENST00000358519.4_Frame_Shift_Ins_p.Q286fs|CNGA1_ENST00000420489.2_Frame_Shift_Ins_p.Q286fs|CNGA1_ENST00000514170.1_Frame_Shift_Ins_p.Q286fs			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	286					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TTTCTGTTCTCTGGAAGAACTC	0.371													15	64	---	---	---	---					
POLR3D	661	broad.mit.edu	37	8	22103087	22103087	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:22103087delC	ENST00000397802.4	+	1	340	c.125delC	c.(124-126)tcfs	p.S42fs	POLR3D_ENST00000306433.4_Frame_Shift_Del_p.S42fs			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	42					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CGCCTTCCCTCCATCCGTTCC	0.677													2	4	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65494020	65494021	+	In_Frame_Ins	INS	-	-	GCA	rs34265378		TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr8:65494020_65494021insGCA	ENST00000321870.1	+	1	1207_1208	c.673_674insGCA	c.(673-675)cag>GCAcag	p.224_225insA	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	224	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.S234delS(1)		NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						cggcagcggcggcagcagcagc	0.718													3	4	---	---	---	---					
COL5A1	1289	broad.mit.edu	37	9	137693829	137693829	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr9:137693829delC	ENST00000371817.3	+	38	3396	c.2982delC	c.(2980-2982)ggfs	p.G994fs		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	994	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.G997fs*17(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GCCCTCCAGGCCCCCCCGGCG	0.657													7	164	---	---	---	---					
RP11-482E14.1	0	broad.mit.edu	37	10	3535406	3535406	+	RNA	DEL	G	G	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr10:3535406delG	ENST00000413993.1	-	0	715																											GGAAAGCGGAGGGAAAGGCCA	0.443													2	4	---	---	---	---					
UTP20	27340	broad.mit.edu	37	12	101679641	101679641	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr12:101679641delC	ENST00000261637.4	+	4	482	c.308delC	c.(307-309)gcfs	p.A103fs		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	103					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AACAGTTTTGCCTATCAACCC	0.368													50	95	---	---	---	---					
DNAJA4	55466	broad.mit.edu	37	15	78565514	78565514	+	Frame_Shift_Del	DEL	A	A	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr15:78565514delA	ENST00000394855.3	+	4	706	c.478delA	c.(478-480)aafs	p.K160fs	DNAJA4_ENST00000343789.3_Frame_Shift_Del_p.K131fs|DNAJA4_ENST00000446172.2_Frame_Shift_Del_p.K104fs|DNAJA4_ENST00000394852.3_Frame_Shift_Del_p.K131fs	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	131					protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						GGCCCTCCAGAAAAATGTAAT	0.338													35	90	---	---	---	---					
IL27	246778	broad.mit.edu	37	16	28511198	28511200	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr16:28511198_28511200delTCC	ENST00000356897.1	-	5	526_528	c.504_506delGGA	c.(502-507)gaa>ga	p.EE174del		NM_145659.3	NP_663634.2	Q8NEV9	IL27A_HUMAN	interleukin 27	174	Glu-rich.				inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding	p.E176delE(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	10						ctcctcctcttcctcctcctcct	0.675													2	4	---	---	---	---					
STAT3	6774	broad.mit.edu	37	17	40481573	40481573	+	Splice_Site	DEL	A	A	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr17:40481573delA	ENST00000264657.5	-	13	1544	c.1233_splice	c.e13+1	p.L411_splice	STAT3_ENST00000389272.3_Splice_Site_p.L313_splice|STAT3_ENST00000585517.1_Splice_Site_p.L411_splice|STAT3_ENST00000588969.1_Splice_Site_p.L411_splice|STAT3_ENST00000404395.3_Splice_Site_p.L411_splice	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	411					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CCCACATACCAAGTGTTTGAA	0.498									Hyperimmunoglobulin E Recurrent Infection Syndrome				33	100	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207065	1207065	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr19:1207065delG	ENST00000326873.7	+	1	1326	c.153delG	c.(151-153)atfs	p.M51fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	51	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.D53fs*11(1)|p.L50_D53del(1)|p.M51fs*14(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTACCTGATGGGGGACCTGC	0.607		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			33	63	---	---	---	---					
DNMT3L	29947	broad.mit.edu	37	21	45671573	45671575	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-73-7498-01A-12D-2184-08	TCGA-73-7498-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a94e7ba6-d27f-4d30-b797-3ecae4a261a2	afd5aa48-8b00-46ce-a6df-16ad4546f282	g.chr21:45671573_45671575delCTC	ENST00000270172.3	-	9	1183_1185	c.700_702delGAG	c.(700-702)del	p.E234del	DNMT3L_ENST00000418993.1_In_Frame_Del_p.E234del	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	234					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AGGGTCCCCACTCCTCCACCTGC	0.650													17	39	---	---	---	---					
