Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZSWIM8	23053	broad.mit.edu	37	10	75550013	75550013	+	Silent	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr10:75550013C>T	ENST00000604729.1	+	7	1201	c.904C>T	c.(904-906)Ctg>Ttg	p.L302L	ZSWIM8_ENST00000605216.1_Silent_p.L302L|ZSWIM8_ENST00000604524.1_Silent_p.L302L|ZSWIM8_ENST00000603114.1_Silent_p.L302L|ZSWIM8_ENST00000398706.2_Silent_p.L302L					zinc finger, SWIM-type containing 8									p.L302L(2)									CAAAAAGACACTGCACAAGTT	0.552000													8	104					0	0	0.038147	0	0
TTN	7273	broad.mit.edu	37	2	179600640	179600640	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr2:179600640C>T	ENST00000589042.1	-	50	14757	c.14533G>A	c.(14533-14535)Gac>Aac	p.D4845N	TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.D3601N|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D4528N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4528	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D3601N(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCTGCGTCGGAAATCCTC	0.438000													10	73					0	0	0.093190	0	0
KCNH1	3756	broad.mit.edu	37	1	211092987	211092987	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr1:211092987A>G	ENST00000367007.4	-	7	1545	c.1376T>C	c.(1375-1377)aTt>aCt	p.I459T	KCNH1_ENST00000271751.4_Missense_Mutation_p.I486T	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	486					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.I486T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTTACAGCCAATCATCATGAT	0.493000													6	145					0	0	0.029380	0	0
PLA2G10	8399	broad.mit.edu	37	16	14766485	14766485	+	Silent	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr16:14766485C>T	ENST00000438167.3	-	4	916	c.477G>A	c.(475-477)ccG>ccA	p.P159P		NM_003561.1	NP_003552.1	O15496	PA2GX_HUMAN	phospholipase A2, group X	159					arachidonic acid metabolic process|axon guidance|cholesterol homeostasis|lipid catabolic process|lysophospholipid transport|negative regulation of cholesterol efflux|negative regulation of sequence-specific DNA binding transcription factor activity|phospholipid metabolic process|positive regulation of arachidonic acid secretion|positive regulation of cellular protein metabolic process|positive regulation of lipid storage|positive regulation of prostaglandin secretion|regulation of macrophage activation	extracellular region	calcium ion binding|phospholipase A2 activity	p.P159P(1)									TGGGCGAGTCCGGCTCACATA	0.443000													25	154					0	0	0.091800	0	0
CDRT1	374286	broad.mit.edu	37	17	15496778	15496778	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr17:15496778G>A	ENST00000395906.3	-	11	1878	c.1879C>T	c.(1879-1881)Cgg>Tgg	p.R627W	RP11-385D13.1_ENST00000455584.2_Intron|CDRT1_ENST00000354433.3_Missense_Mutation_p.R127W|CDRT1_ENST00000583965.1_Intron	NM_006382.3	NP_006373.2	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	627										endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		CTGATGACCCGGAGGAAGAGA	0.498000													4	189					0	0	0.009096	0	0
METTL17	64745	broad.mit.edu	37	14	21464765	21464765	+	Missense_Mutation	SNP	G	G	A	rs144273829		TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr14:21464765G>A	ENST00000339374.6	+	13	1393	c.1160G>A	c.(1159-1161)cGt>cAt	p.R387H	METTL17_ENST00000382985.4_Missense_Mutation_p.R387H|METTL17_ENST00000556670.2_Missense_Mutation_p.R387H|RP11-84C10.4_ENST00000557335.1_RNA	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	387					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity	p.R387H(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CGCTGGCCCCGTATCACTCAG	0.537000													8	48					0	0	0.047766	0	0
LRRN4	164312	broad.mit.edu	37	20	6022727	6022727	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr20:6022727G>A	ENST00000378858.4	-	5	1388	c.1164C>T	c.(1162-1164)acC>acT	p.T388T		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	388						integral to membrane		p.T388T(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						TGGGCGCGACGGTGGTACCCT	0.677000													7	39					0	0	0.058154	0	0
RYR3	6263	broad.mit.edu	37	15	33765678	33765678	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr15:33765678G>A	ENST00000389232.4	+	2	180	c.110G>A	c.(109-111)tGc>tAc	p.C37Y	RYR3_ENST00000415757.3_Missense_Mutation_p.C37Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	37					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.C37Y(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGAAGTTCTGCCTGGCAGCC	0.547000													9	55					0	0	0.080935	0	0
UNC5C	8633	broad.mit.edu	37	4	96163597	96163597	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr4:96163597T>A	ENST00000453304.1	-	7	1439	c.1091A>T	c.(1090-1092)gAt>gTt	p.D364V	UNC5C_ENST00000506749.1_Missense_Mutation_p.D364V	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	364	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity	p.D364V(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCAAAGCCCATCAGTGCAGTT	0.512000													6	36					0	0	0.021553	0	0
LCMT1	51451	broad.mit.edu	37	16	25175976	25175976	+	Silent	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr16:25175976C>T	ENST00000399069.3	+	7	782	c.627C>T	c.(625-627)tcC>tcT	p.S209S	LCMT1_ENST00000572869.1_3'UTR|LCMT1_ENST00000380966.4_Silent_p.S154S	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	209							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity	p.S209S(1)							GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CAGAGCAGTCCGCAAACCTCC	0.428000													12	87					0	0	0.080935	0	0
ANK3	288	broad.mit.edu	37	10	61830854	61830854	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr10:61830854G>A	ENST00000280772.1	-	37	9976	c.9785C>T	c.(9784-9786)gCg>gTg	p.A3262V	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3262					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AATCTGGTCCGCATCCAGTGG	0.438000													4	168					0	0	0.014758	0	0
ARPP21	10777	broad.mit.edu	37	3	35785377	35785377	+	Missense_Mutation	SNP	C	C	T	rs139862817	byFrequency	TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr3:35785377C>T	ENST00000187397.4	+	18	2408	c.1952C>T	c.(1951-1953)aCg>aTg	p.T651M	ARPP21_ENST00000444190.1_Missense_Mutation_p.T632M|ARPP21_ENST00000458225.1_Missense_Mutation_p.T652M|ARPP21_ENST00000417925.1_Missense_Mutation_p.T652M|ARPP21_ENST00000337271.5_Missense_Mutation_p.T632M	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	651	Gln-rich.					cytoplasm	nucleic acid binding	p.T651M(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ACCTCAACCACGCAACAGTAC	0.478000													9	110					0	0	0.058154	0	0
OR5I1	10798	broad.mit.edu	37	11	55703528	55703528	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr11:55703528G>T	ENST00000301532.3	-	1	348	c.349C>A	c.(349-351)Ctg>Atg	p.L117M		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L117M(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						ATGGCGGCCAGGATGAAGGAT	0.443000													11	36					2.80697e-09	3.50872e-09	0.080935	1	0
PAK7	57144	broad.mit.edu	37	20	9546621	9546621	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr20:9546621G>A	ENST00000378429.3	-	6	1947	c.1401C>T	c.(1399-1401)acC>acT	p.T467T	PAK7_ENST00000353224.5_Silent_p.T467T|PAK7_ENST00000378423.1_Silent_p.T467T	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	467	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity	p.T467T(1)		NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TGTGTTTCTCGGTGGCGATGC	0.522000													17	165					0	0	0.033300	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413949	105413949	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr14:105413949G>A	ENST00000333244.5	-	7	7958	c.7839C>T	c.(7837-7839)agC>agT	p.S2613S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2613						nucleus		p.S2613S(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCACCTCCATGCTGGACAGAG	0.632000													36	191					0	0	0.074837	0	0
FAT3	120114	broad.mit.edu	37	11	92616397	92616397	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr11:92616397G>A	ENST00000298047.6	+	23	12792	c.12775G>A	c.(12775-12777)Gag>Aag	p.E4259K	FAT3_ENST00000533797.1_Missense_Mutation_p.E594K|FAT3_ENST00000409404.2_Missense_Mutation_p.E4259K|FAT3_ENST00000525166.1_Missense_Mutation_p.E4109K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4259					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.E4259K(2)|p.E834K(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGAGGCGAGCACCAGGA	0.682000										TCGA Ovarian(4;0.039)			17	116					0	0	0.038395	0	0
EPHA3	2042	broad.mit.edu	37	3	89456471	89456471	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr3:89456471G>A	ENST00000336596.2	+	8	1872	c.1647G>A	c.(1645-1647)gcG>gcA	p.A549A	EPHA3_ENST00000494014.1_Silent_p.A549A	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	549						extracellular region|integral to plasma membrane	ATP binding	p.A549A(1)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCATTTCAGCGGCAGTAGCAA	0.398000										TSP Lung(6;0.00050)			3	51					0	0	0.004672	0	0
HCFC1	3054	broad.mit.edu	37	X	153228790	153228790	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chrX:153228790G>A	ENST00000310441.7	-	4	1564	c.598C>T	c.(598-600)Cgg>Tgg	p.R200W	HCFC1_ENST00000369984.4_Missense_Mutation_p.R200W|HCFC1_ENST00000354233.3_Missense_Mutation_p.R200W	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	200					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R101W(1)|p.R200W(1)		NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTGACTCCCGGGGTGGTGGT	0.552000													24	89					0	0	0.091800	0	0
F8	2157	broad.mit.edu	37	X	154088755	154088755	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chrX:154088755A>T	ENST00000360256.4	-	25	7052	c.6852T>A	c.(6850-6852)agT>agA	p.S2284R	F8_ENST00000330287.6_Missense_Mutation_p.S149R	NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2284	F5/8 type C 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding	p.S2284R(2)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGCCATCTTGACTGCTGGAGA	0.418000													23	263					0	0	0.083992	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579720	44579720	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr7:44579720G>A	ENST00000289547.4	-	2	331	c.276C>T	c.(274-276)tcC>tcT	p.S92S	NPC1L1_ENST00000423141.1_Silent_p.S92S|NPC1L1_ENST00000546276.1_Silent_p.S92S|NPC1L1_ENST00000381160.3_Silent_p.S92S	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	92					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding	p.S92S(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GCTGCTTGGCGGAGCAGCAGG	0.602000													3	35					0	0	0.004672	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47649678	47649678	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr1:47649678delC	ENST00000294338.2	-	4	432	c.310delG	c.(310-312)agfs	p.E106fs	PDZK1IP1_ENST00000371885.1_Frame_Shift_Del_p.E106fs|PDZK1IP1_ENST00000491793.1_5'UTR	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	106						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						CCTTCCTCCTCGGGCACATTC	0.572													2	4	---	---	---	---					
GDF7	151449	broad.mit.edu	37	2	20867303	20867303	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr2:20867303delA	ENST00000272224.3	+	1	880	c.304delA	c.(304-306)ggfs	p.R102fs		NM_182828.2	NP_878248.2	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7	102					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|cervix(1)|endometrium(2)|lung(1)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGGCCGGGAGGGCTCCGGC	0.731													2	4	---	---	---	---					
KCNN2	3781	broad.mit.edu	37	5	113699634	113699634	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr5:113699634delT	ENST00000512097.3	+	3	1536	c.518delT	c.(517-519)ctfs	p.L173fs	KCNN2_ENST00000264773.3_Frame_Shift_Del_p.L173fs|KCNN2_ENST00000507750.1_3'UTR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	173						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGAAATGCCTTATCAGTCTC	0.483													10	92	---	---	---	---					
