Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SH3TC1	54436	broad.mit.edu	37	4	8233746	8233746	+	Silent	SNP	C	C	T	rs141442802		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr4:8233746C>T	ENST00000539824.1	+	13	3140	c.2766C>T	c.(2764-2766)gcC>gcT	p.A922A	SH3TC1_ENST00000245105.3_Silent_p.A998A			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	998							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TCTACAGCGCCGTCATGCCCA	0.637000													28	58					0	0	0.006320	0	0
KIF14	9928	broad.mit.edu	37	1	200559401	200559401	+	Splice_Site	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:200559401C>T	ENST00000367350.4	-	17	3252		c.e17-1			NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TGCTTCAAGTCTACAATGTAG	0.338000													6	82					0	0	0.001984	0	0
GH1	2688	broad.mit.edu	37	17	61995414	61995414	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr17:61995414G>A	ENST00000323322.5	-	3	296	c.254C>T	c.(253-255)cCg>cTg	p.P85L	GH1_ENST00000458650.2_Missense_Mutation_p.P70L|GH1_ENST00000342364.4_Intron|CSHL1_ENST00000392824.4_Intron|GH1_ENST00000351388.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	85					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						GGAGGGTGTCGGAATAGACTC	0.562000													27	160					0	0	0.004656	0	0
CSMD2	114784	broad.mit.edu	37	1	34204868	34204868	+	Silent	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:34204868G>A	ENST00000373381.4	-	15	2417	c.2241C>T	c.(2239-2241)ctC>ctT	p.L747L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	707	Sushi 4.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGCCCAGCTGGAGGCTGTCCC	0.572000													15	76					0	0	0.004007	0	0
VANGL1	81839	broad.mit.edu	37	1	116206601	116206601	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:116206601G>A	ENST00000355485.2	+	4	795	c.524G>A	c.(523-525)cGg>cAg	p.R175Q	VANGL1_ENST00000369510.3_Missense_Mutation_p.R173Q|VANGL1_ENST00000369509.1_Missense_Mutation_p.R175Q|VANGL1_ENST00000310260.3_Missense_Mutation_p.R175Q	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	175			R -> Q.		multicellular organismal development	integral to membrane	protein binding	p.F171fs*93(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTCCGCAAGCGGAGAGCTGAC	0.493000													26	147					0	0	0.004656	0	0
CACNG3	10368	broad.mit.edu	37	16	24366264	24366264	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:24366264C>T	ENST00000005284.3	+	3	1608	c.406C>T	c.(406-408)Ctc>Ttc	p.L136F		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	136					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CAACGTCATTCTCAGCGCGGG	0.587000													3	55					0	0	0.009096	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													3	64					0	0	0.000602	0	0
KLHL38	340359	broad.mit.edu	37	8	124664255	124664255	+	Silent	SNP	C	C	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr8:124664255C>G	ENST00000325995.7	-	1	935	c.912G>C	c.(910-912)ctG>ctC	p.L304L	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	304										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						GTTTGCTGTACAGTAGGACGT	0.557000													3	76					0	0	0.004672	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95200144	95200144	+	Silent	SNP	A	A	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr4:95200144A>G	ENST00000354268.4	+	19	2434	c.2361A>G	c.(2359-2361)ttA>ttG	p.L787L	SMARCAD1_ENST00000509418.1_Silent_p.L357L|SMARCAD1_ENST00000457823.2_Silent_p.L789L			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	787					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		ATCCTTTATTACATCGCCAAT	0.338000													4	26					0	0	0.009096	0	0
NFKB1	4790	broad.mit.edu	37	4	103517305	103517305	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr4:103517305C>A	ENST00000226574.4	+	14	1778	c.1311C>A	c.(1309-1311)gaC>gaA	p.D437E	NFKB1_ENST00000394820.4_Missense_Mutation_p.D436E|NFKB1_ENST00000600343.1_Missense_Mutation_p.D256E|NFKB1_ENST00000505458.1_Missense_Mutation_p.D436E	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	436	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GAACCATGGACACTGAATCTA	0.353000													24	48					8.24728e-16	1.03091e-15	0.004656	1	0
HECW1	23072	broad.mit.edu	37	7	43484503	43484503	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr7:43484503G>A	ENST00000395891.1	+	11	2337	c.1732G>A	c.(1732-1734)Gcg>Acg	p.A578T	HECW1_ENST00000453890.1_Missense_Mutation_p.A578T	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	578					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GGGCGGCAGCGCGGCAGAGGA	0.701000													13	53					0	0	0.001855	0	0
IBTK	25998	broad.mit.edu	37	6	82933844	82933844	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr6:82933844T>G	ENST00000306270.7	-	7	1433	c.884A>C	c.(883-885)cAt>cCt	p.H295P	IBTK_ENST00000510291.1_Missense_Mutation_p.H295P|IBTK_ENST00000503631.1_Missense_Mutation_p.H295P	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	295					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TAGGACTGTATGAAACCTGCC	0.348000													4	64					0	0	0.000602	0	0
DAXX	1616	broad.mit.edu	37	6	33286535	33286535	+	Silent	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr6:33286535G>A	ENST00000374542.5	-	8	2412	c.2208C>T	c.(2206-2208)ctC>ctT	p.L736L	DAXX_ENST00000414083.2_Silent_p.L661L|DAXX_ENST00000266000.6_Silent_p.L736L	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	736	Interaction with SPOP.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						CAGAGTCTGAGAGCACGATGA	0.498000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								11	39					0	0	0.010729	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185390422	185390422	+	Silent	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr3:185390422G>A	ENST00000382199.2	-	10	1202	c.1107C>T	c.(1105-1107)agC>agT	p.S369S	IGF2BP2_ENST00000346192.3_Intron|IGF2BP2_ENST00000421047.2_Silent_p.S312S|IGF2BP2_ENST00000457616.2_Silent_p.S375S|IGF2BP2_ENST00000494906.1_Intron	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	369					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TGCCAAGTGCGCTGAGGTTCA	0.577000													4	30					0	0	0.009096	0	0
GSTA2	2939	broad.mit.edu	37	6	52619840	52619840	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr6:52619840A>G	ENST00000493422.1	-	4	328	c.173T>C	c.(172-174)gTt>gCt	p.V58A		NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	58	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	ATCAATCTCAACCATTGGCAC	0.413000													3	97					0	0	0.009096	0	0
EFCAB3	146779	broad.mit.edu	37	17	60483983	60483983	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr17:60483983A>T	ENST00000450662.2	+	9	858	c.787A>T	c.(787-789)Att>Ttt	p.I263F	EFCAB3_ENST00000305286.3_Missense_Mutation_p.I211F	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	211							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			TGCTGCCCGGATTGCAATAAT	0.403000													3	25					0	0	0.004672	0	0
MAGEC3	139081	broad.mit.edu	37	X	140953388	140953388	+	Silent	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chrX:140953388C>T	ENST00000298296.1	+	2	255	c.255C>T	c.(253-255)ttC>ttT	p.F85F		NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	85										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCACATACTTCAAGGTAAGGA	0.537000													6	71					0	0	0.001984	0	0
SETD2	29072	broad.mit.edu	37	3	47162475	47162475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr3:47162475C>T	ENST00000409792.3	-	3	3693	c.3651G>A	c.(3649-3651)tgG>tgA	p.W1217*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGGTCTGTTGCCAAGACTTAT	0.413000			"""N, F, S, Mis"""		clear cell renal carcinoma								22	69					0	0	0.002780	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745823	96745823	+	Silent	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr10:96745823C>T	ENST00000260682.6	+	8	1195	c.1183C>T	c.(1183-1185)Cta>Tta	p.L395L		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	395					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GACTTCTGTGCTACATGACAA	0.388000													5	97					0	0	0.001168	0	0
GTSE1	51512	broad.mit.edu	37	22	46704460	46704460	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr22:46704460G>T	ENST00000454366.1	+	4	594	c.382G>T	c.(382-384)Gac>Tac	p.D128Y		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	109					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CAAGCCTGAAGACCCTCGGAG	0.488000													4	61					0.00024832	0.000298904	0.009096	1	0
INPP4B	8821	broad.mit.edu	37	4	143114338	143114338	+	Silent	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr4:143114338G>A	ENST00000513000.1	-	16	1516	c.1083C>T	c.(1081-1083)taC>taT	p.Y361Y	INPP4B_ENST00000308502.4_Silent_p.Y361Y|INPP4B_ENST00000508116.1_Silent_p.Y361Y|INPP4B_ENST00000262992.4_Silent_p.Y361Y|INPP4B_ENST00000509777.1_Silent_p.Y361Y	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	361					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TGATGACATCGTAGAGAGCAT	0.428000													19	98					0	0	0.007413	0	0
CACNG3	10368	broad.mit.edu	37	16	24358138	24358138	+	Splice_Site	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:24358138C>T	ENST00000005284.3	+	2	1497	c.295_splice	c.e2+1	p.R99_splice		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	99					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		ATATCTCCTGCGTAAGTTCCC	0.552000													8	48					0	0	0.004482	0	0
LRFN3	79414	broad.mit.edu	37	19	36430831	36430831	+	Silent	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr19:36430831C>T	ENST00000588831.1	+	3	1558	c.504C>T	c.(502-504)ctC>ctT	p.L168L	LRFN3_ENST00000246529.3_Silent_p.L168L			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	168					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			ACAACAACCTCGAGCAGCTGC	0.657000													33	69					0	0	0.012213	0	0
CAPN15	6650	broad.mit.edu	37	16	601602	601602	+	Silent	SNP	C	C	T	rs143386541		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:601602C>T	ENST00000219611.2	+	9	2646	c.2283C>T	c.(2281-2283)ggC>ggT	p.G761G	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		ACCTGCGTGGCGAGCTCATGC	0.682000													11	79					0	0	0.010729	0	0
AHCTF1	25909	broad.mit.edu	37	1	247013024	247013024	+	Missense_Mutation	SNP	C	C	T	rs144318625	by1000genomes	TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:247013024C>T	ENST00000366508.1	-	33	6525	c.6389G>A	c.(6388-6390)cGc>cAc	p.R2130H	AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Missense_Mutation_p.R2095H|AHCTF1_ENST00000326225.3_Missense_Mutation_p.R2104H			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	2095	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCTGCTGCTGCGGGATGATTT	0.458000													5	59					0	0	0.000602	0	0
CD2	914	broad.mit.edu	37	1	117311354	117311354	+	Silent	SNP	A	A	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:117311354A>C	ENST00000369478.3	+	5	1113	c.1005A>C	c.(1003-1005)ccA>ccC	p.P335P		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	335	Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GAGTTCAGCCAAAACCTCCCC	0.517000													3	120					0	0	0.004672	0	0
M6PR	4074	broad.mit.edu	37	12	9098883	9098883	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr12:9098883T>C	ENST00000000412.3	-	2	586	c.118A>G	c.(118-120)Aaa>Gaa	p.K40E		NM_002355.3	NP_002346.1	P20645	MPRD_HUMAN	mannose-6-phosphate receptor (cation dependent)	40					endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(1)	11		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		TCTGACTCTTTACCCTTTTCT	0.428000													4	92					0	0	0.009096	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128851343	128851343	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr11:128851343C>T	ENST00000310343.9	-	16	1705	c.1706G>A	c.(1705-1707)gGc>gAc	p.G569D	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.G220D|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.G220D|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.G495D	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	569					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GCTGATTCTGCCGCTGAACAG	0.537000													4	86					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179399027	179399027	+	Silent	SNP	A	A	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr2:179399027A>G	ENST00000589042.1	-	358	102539	c.102315T>C	c.(102313-102315)gtT>gtC	p.V34105V	TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.V32464V|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN_ENST00000342992.6_Silent_p.V31537V|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.V25040V|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN_ENST00000342175.6_Silent_p.V25232V|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000359218.5_Silent_p.V25165V|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592182.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32464	Ig-like 151.|Ser-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCTGACACAACCATGTTGA	0.443000													3	102					0	0	0.004672	0	0
EMC2	9694	broad.mit.edu	37	8	109498762	109498762	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr8:109498762G>A	ENST00000220853.3	+	11	864	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		AAGTAAGAAGGAAACCAAATA	0.338000													7	21					0	0	0.004482	0	0
MARCH1	55016	broad.mit.edu	37	4	164507069	164507069	+	Silent	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr4:164507069G>A	ENST00000503008.1	-	6	1231	c.255C>T	c.(253-255)tgC>tgT	p.C85C	MARCH1_ENST00000274056.7_Silent_p.C85C|MARCH1_ENST00000339875.5_Silent_p.C68C|MARCH1_ENST00000514618.1_Silent_p.C341C	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	85					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.C68C(1)|p.C85C(1)		endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CATCCCCTTCGCAGTGACAGA	0.527000													10	22					0	0	0.006214	0	0
HERC2	8924	broad.mit.edu	37	15	28447338	28447338	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr15:28447338A>G	ENST00000261609.7	-	47	7646	c.7538T>C	c.(7537-7539)cTc>cCc	p.L2513P		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2513					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGCATCTGAGAGCTCCGTGAC	0.587000													9	32					0	0	0.006214	0	0
CTNNA2	1496	broad.mit.edu	37	2	80101465	80101465	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr2:80101465T>G	ENST00000466387.1	+	10	1573	c.849T>G	c.(847-849)ttT>ttG	p.F283L	CTNNA2_ENST00000402739.4_Missense_Mutation_p.F283L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.F283L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.F283L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.F317L|CTNNA2_ENST00000541047.1_Missense_Mutation_p.F283L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	283					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TTAATGAGTTTGACGTAAGCA	0.517000													11	55					0	0	0.001368	0	0
KTN1	3895	broad.mit.edu	37	14	56106693	56106693	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr14:56106693G>A	ENST00000416613.1	+	13	1958	c.1886G>A	c.(1885-1887)cGt>cAt	p.R629H	KTN1_ENST00000395311.1_Missense_Mutation_p.R629H|KTN1_ENST00000395309.3_Missense_Mutation_p.R629H|KTN1_ENST00000395314.3_Missense_Mutation_p.R629H|KTN1_ENST00000438792.2_Missense_Mutation_p.R629H|KTN1_ENST00000413890.2_Missense_Mutation_p.R629H|KTN1_ENST00000395308.1_Missense_Mutation_p.R629H			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	629					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						GAACGTGATCGTTTAACAAGT	0.299000			T	RET	papillary thryoid								19	129					0	0	0.002299	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	46					0	0	0.004672	0	0
PLVAP	83483	broad.mit.edu	37	19	17476311	17476311	+	Silent	SNP	C	C	T	rs150210307		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr19:17476311C>T	ENST00000252590.4	-	3	1024	c.963G>A	c.(961-963)gcG>gcA	p.A321A		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCTTCTGTTTCGCCTCCTGAC	0.667000													10	23					0	0	0.006214	0	0
XPO4	64328	broad.mit.edu	37	13	21375083	21375083	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr13:21375083T>C	ENST00000400602.2	-	14	1899	c.1864A>G	c.(1864-1866)Ata>Gta	p.I622V	XPO4_ENST00000255305.6_Missense_Mutation_p.I622V	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	622					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TCTGCTCTTATTGCTCGAGAT	0.378000													4	80					0	0	0.001168	0	0
TBC1D24	57465	broad.mit.edu	37	16	2550823	2550823	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:2550823C>T	ENST00000567020.1	+	7	1666	c.1526C>T	c.(1525-1527)gCg>gTg	p.A509V	TBC1D24_ENST00000293970.5_Missense_Mutation_p.A515V|TBC1D24_ENST00000434757.2_Missense_Mutation_p.A515V|RP11-20I23.1_ENST00000564543.1_Intron	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	515	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						GGCGGCCAGGCGCTCTACATC	0.642000											OREG0023552	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0	0	0.000602	0	0
TAP2	6891	broad.mit.edu	37	6	32803014	32803014	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr6:32803014T>C	ENST00000374897.2	-	5	993	c.862A>G	c.(862-864)Ata>Gta	p.I288V	TAP2_ENST00000374899.4_Missense_Mutation_p.I288V|TAP2_ENST00000452392.2_Missense_Mutation_p.I288V	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	288	ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										CGAGGCGATATGCTGAGCATG	0.532000													12	29					0	0	0.010729	0	0
NTNG1	22854	broad.mit.edu	37	1	108023306	108023306	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:108023306C>G	ENST00000370067.1	+	7	1854	c.1227C>G	c.(1225-1227)tgC>tgG	p.C409W	NTNG1_ENST00000542803.1_Missense_Mutation_p.C488W|NTNG1_ENST00000370061.3_Missense_Mutation_p.C454W|NTNG1_ENST00000370066.1_Missense_Mutation_p.C429W|NTNG1_ENST00000370068.1_Missense_Mutation_p.C488W|NTNG1_ENST00000370065.1_Missense_Mutation_p.C443W|NTNG1_ENST00000370072.3_Missense_Mutation_p.C443W|NTNG1_ENST00000370070.2_Missense_Mutation_p.C409W|NTNG1_ENST00000370071.2_Missense_Mutation_p.C429W|NTNG1_ENST00000370074.4_Missense_Mutation_p.C387W|NTNG1_ENST00000370073.2_Missense_Mutation_p.C488W			Q9Y2I2	NTNG1_HUMAN	netrin G1	440	Laminin EGF-like 2.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GCTGCCTGTGCCCGGCCGCAT	0.682000													4	44					0	0	0.001168	0	0
CHD9	80205	broad.mit.edu	37	16	53341792	53341792	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:53341792A>G	ENST00000566029.1	+	33	7189	c.6980A>G	c.(6979-6981)cAt>cGt	p.H2327R	CHD9_ENST00000447540.1_Missense_Mutation_p.H2328R|CHD9_ENST00000398510.3_Missense_Mutation_p.H2327R|CHD9_ENST00000564845.1_Missense_Mutation_p.H2327R			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2327					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AAAGAAGAACATGATCAGTCA	0.453000													4	26					0	0	0.004482	0	0
DMBT1	1755	broad.mit.edu	37	10	124399788	124399788	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr10:124399788C>T	ENST00000368909.3	+	52	6894	c.6788C>T	c.(6787-6789)tCa>tTa	p.S2263L	DMBT1_ENST00000338354.3_Missense_Mutation_p.S2263L|DMBT1_ENST00000359586.6_Missense_Mutation_p.S983L|DMBT1_ENST00000368955.3_Missense_Mutation_p.S2253L|DMBT1_ENST00000344338.3_Missense_Mutation_p.S2253L|DMBT1_ENST00000330163.4_Missense_Mutation_p.S1635L|DMBT1_ENST00000368956.2_Missense_Mutation_p.S1635L	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2263	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TATACTTCCTCATCTTTCTTG	0.458000													7	95					0	0	0.001984	0	0
GYG1	2992	broad.mit.edu	37	3	148744703	148744703	+	Missense_Mutation	SNP	G	G	A	rs141679018		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr3:148744703G>A	ENST00000345003.4	+	8	1336	c.1036G>A	c.(1036-1038)Gac>Aac	p.D346N	GYG1_ENST00000484197.1_Silent_p.L255L|GYG1_ENST00000479119.1_3'UTR|GYG1_ENST00000296048.6_Missense_Mutation_p.D329N	NM_004130.3	NP_004121.2	P46976	GLYG_HUMAN	glycogenin 1	346					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GAGGAAACTTGACACTTACCT	0.443000													13	55					0	0	0.004007	0	0
NOMO1	23420	broad.mit.edu	37	16	14988854	14988854	+	Splice_Site	SNP	G	G	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr16:14988854G>C	ENST00000287667.7	+	30	3615		c.e30-1			NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1							integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GGTGTTTGCAGAGGAAGCTGC	0.562000													5	160					0	0	0.004482	0	0
MMP19	4327	broad.mit.edu	37	12	56231671	56231671	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr12:56231671G>A	ENST00000394182.1	-	2	157	c.158C>T	c.(157-159)gCt>gTt	p.A53V	MMP19_ENST00000548629.1_Missense_Mutation_p.A316V|MMP19_ENST00000409200.3_Silent_p.C292C|MMP19_ENST00000322569.4_Missense_Mutation_p.A339V			Q99542	MMP19_HUMAN	matrix metallopeptidase 19	339					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						GTAGACAGCAGCATCCAGGTT	0.512000													20	75					0	0	0.008871	0	0
GAPT	202309	broad.mit.edu	37	5	57790790	57790790	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr5:57790790G>A	ENST00000396776.2	+	3	889	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	GAPT_ENST00000318469.2_Missense_Mutation_p.E143K	NM_152687.2	NP_689900.1	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	143					B cell activation	integral to membrane|plasma membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7						TCGTCCTTCTGAAGTTCCTCA	0.328000													24	48					0	0	0.004656	0	0
SLC51A	200931	broad.mit.edu	37	3	195955002	195955002	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr3:195955002T>C	ENST00000296327.5	+	5	588	c.379T>C	c.(379-381)Ttt>Ctt	p.F127L		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		TGCCGTGTGCTTTTACCTGCT	0.602000													4	221					0	0	0.009096	0	0
RSC1A1	6248	broad.mit.edu	37	1	15987729	15987729	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:15987729G>A	ENST00000345034.1	+	1	1366	c.1366G>A	c.(1366-1368)Gat>Aat	p.D456N	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	456					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGTCAACCGATAAGGAAGG	0.423000													10	21					0	0	0.006214	0	0
LOC100129620	100129620	broad.mit.edu	37	1	99474094	99474094	+	RNA	DEL	A	A	-	rs57656522		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr1:99474094delA	ENST00000425113.1	+	0	370					NR_033940.1																						AACAGCAACTAAAAAAAAAAA	0.353													3	6	---	---	---	---					
MYO7B	4648	broad.mit.edu	37	2	128367204	128367205	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr2:128367204_128367205insA	ENST00000389524.4	+	23	2991_2992	c.2938_2939insA	c.(2938-2940)cttfs	p.L980fs	MYO7B_ENST00000409816.2_Frame_Shift_Ins_p.L980fs|MYO7B_ENST00000428314.1_Frame_Shift_Ins_p.L980fs			Q6PIF6	MYO7B_HUMAN	myosin VIIB	980						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCTGTGACTTACTTCCAGAAA	0.574													28	80	---	---	---	---					
FEV	54738	broad.mit.edu	37	2	219848978	219848978	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr2:219848978delC	ENST00000295727.1	-	2	683	c.102delG	c.(100-102)ggfs	p.G34fs		NM_017521.2	NP_059991.1	Q99581	FEV_HUMAN	FEV (ETS oncogene family)	34					cell differentiation|nervous system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity		EWSR1/FEV(11)|FUS/FEV(2)	large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCTCAGCGGCCCCCAGCTCG	0.652			T	"""EWSR1,  FUS"""	Ewing sarcoma								2	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242465	55242479	+	In_Frame_Del	DEL	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	-	rs121913438		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr7:55242465_55242479delGGAATTAAGAGAAGC	ENST00000275493.2	+	19	2412_2426	c.2235_2249delGGAATTAAGAGAAGC	c.(2233-2250)aaa>aa	p.KELREA745del	EGFR_ENST00000454757.2_In_Frame_Del_p.KELREA692del|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_In_Frame_Del_p.KELREA700del	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	745	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.K745_E746insIPVAIK(5)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.A750_E758>P(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.A750_K754del(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.E749G(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.A750_E758del(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_E746insTPVAIK(1)|p.K745_A750del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCGCTATCAAGGAATTAAGAGAAGCAACATCTCCG	0.479	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			19	54	---	---	---	---					
ODF1	4956	broad.mit.edu	37	8	103572984	103572992	+	In_Frame_Del	DEL	TGCAGCCCC	TGCAGCCCC	-	rs3018444	byFrequency	TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr8:103572984_103572992delTGCAGCCCC	ENST00000285402.3	+	2	781_789	c.625_633delTGCAGCCCC	c.(625-633)del	p.CSP215del	ODF1_ENST00000518835.1_Splice_Site_p.3_splice	NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	215	C-X-P repeat region.				cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CACTTCTCCTtgcagcccctgcagcccct	0.584													8	51	---	---	---	---					
CTD-2509G16.5	0	broad.mit.edu	37	14	65748001	65748002	+	RNA	INS	-	-	TT	rs1760975		TCGA-75-7025-01A-12D-1945-08	TCGA-75-7025-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17e3b2f9-1645-4315-9897-31eb2893345c	dcddb05c-169b-4149-ba9b-840f18bc135d	g.chr14:65748001_65748002insTT	ENST00000553754.1	-	0	300																											TTCTTTCtttcttttttttttt	0.485													3	3	---	---	---	---					
