Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IGHV3OR16-8	388255	broad.mit.edu	37	16	33020647	33020647	+	RNA	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:33020647T>A	ENST00000565407.2	+	0	55				RP11-19N8.2_ENST00000567619.1_RNA																							AGGTGCCCAGTGTGAGGTGCA	0.537000													48	84					0	0	0.003610	0	0
TIAM2	26230	broad.mit.edu	37	6	155465784	155465784	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:155465784G>T	ENST00000461783.3	+	8	2948	c.1675G>T	c.(1675-1677)Gat>Tat	p.D559Y	TIAM2_ENST00000318981.5_Missense_Mutation_p.D559Y|TIAM2_ENST00000456144.1_Missense_Mutation_p.D559Y|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000360366.4_Missense_Mutation_p.D559Y|TIAM2_ENST00000529824.2_Missense_Mutation_p.D559Y			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	559	PH 1.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAATTCCATGGATCAGAGCAG	0.488000													28	40					1.17739e-12	1.93518e-12	0.005443	1	0
DGKI	9162	broad.mit.edu	37	7	137092687	137092687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:137092687A>T	ENST00000453654.1	-	30	2424	c.1885T>A	c.(1885-1887)Tgt>Agt	p.C629S	DGKI_ENST00000424189.2_Missense_Mutation_p.C973S|DGKI_ENST00000494390.1_5'UTR|DGKI_ENST00000288490.5_Missense_Mutation_p.C960S|DGKI_ENST00000446122.1_Missense_Mutation_p.C942S			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	960					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						AGGAGTGAACAGTGGTCTGGT	0.443000													35	56					0	0	0.003755	0	0
DISP2	85455	broad.mit.edu	37	15	40655997	40655997	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:40655997G>A	ENST00000267889.3	+	2	378	c.291G>A	c.(289-291)cgG>cgA	p.R97R		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	97					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCTATCCCCGGGCACTGCAGG	0.657000													24	34					0	0	0.002780	0	0
GK	2710	broad.mit.edu	37	X	30709269	30709269	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:30709269G>T	ENST00000378943.3	+	5	546	c.367G>T	c.(367-369)Gtt>Ttt	p.V123F	GK_ENST00000378945.3_Missense_Mutation_p.V123F|GK_ENST00000378946.3_Missense_Mutation_p.V123F|GK_ENST00000427190.1_5'UTR	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	123					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						CCAGTCTACCGTTGAGAGTCT	0.269000													31	56					9.17885e-22	1.7951e-21	0.003271	1	0
SLC9A6	10479	broad.mit.edu	37	X	135095150	135095150	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:135095150A>G	ENST00000370695.4	+	8	1119	c.1084A>G	c.(1084-1086)Aca>Gca	p.T362A	SLC9A6_ENST00000370698.3_Missense_Mutation_p.T330A|SLC9A6_ENST00000370701.1_Missense_Mutation_p.T310A	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	330					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					GTTGTTGGAGACAGGCCTGTT	0.438000													72	134					0	0	0.003610	0	0
CENPU	79682	broad.mit.edu	37	4	185622019	185622019	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:185622019T>A	ENST00000281453.5	-	11	1011	c.941A>T	c.(940-942)gAa>gTa	p.E314V	MLF1IP_ENST00000506535.1_Intron|MLF1IP_ENST00000541971.1_Missense_Mutation_p.E314V	NM_024629.3	NP_078905.2	Q71F23	CENPU_HUMAN		314					CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|stomach(1)	13		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		CCTTTTCTTTTCGATATCTGA	0.373000													19	47					0	0	0.002299	0	0
ZNF816	125893	broad.mit.edu	37	19	53454526	53454526	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:53454526G>A	ENST00000357666.4	-	5	802	c.502C>T	c.(502-504)Cac>Tac	p.H168Y	ZNF816_ENST00000444460.2_Missense_Mutation_p.H168Y|ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000434371.2_Intron	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H168N(1)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						TGAAACATGTGGAGTTCAGGC	0.423000													30	110					0	0	0.008361	0	0
FAM189A2	9413	broad.mit.edu	37	9	71992567	71992567	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:71992567G>T	ENST00000257515.8	+	6	821	c.401G>T	c.(400-402)gGa>gTa	p.G134V	FAM189A2_ENST00000303068.7_5'UTR|FAM189A2_ENST00000455972.1_Missense_Mutation_p.G134V	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	134						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						GAGGATCATGGACGCATCCCC	0.527000													23	15					5.45024e-15	9.46137e-15	0.003330	1	0
TMTC3	160418	broad.mit.edu	37	12	88548080	88548080	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:88548080G>T	ENST00000266712.6	+	4	644	c.424G>T	c.(424-426)Gga>Tga	p.G142*		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	142						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						AGGAGTTGTTGGAAGAGCAGA	0.299000													16	21					2.48551e-13	4.15147e-13	0.004990	1	0
OCRL	4952	broad.mit.edu	37	X	128722933	128722933	+	Silent	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:128722933T>C	ENST00000371113.4	+	22	2577	c.2412T>C	c.(2410-2412)tgT>tgC	p.C804C	OCRL_ENST00000357121.5_Silent_p.C796C	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	804	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						CAGTCATCTGTTACGAGCTGT	0.527000													35	55					0	0	0.005524	0	0
BCORL1	63035	broad.mit.edu	37	X	129185893	129185893	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:129185893A>T	ENST00000540052.1	+	11	4799	c.4755A>T	c.(4753-4755)caA>caT	p.Q1585H	BCORL1_ENST00000359304.2_Missense_Mutation_p.Q1455H|BCORL1_ENST00000303743.5_Missense_Mutation_p.Q1659H|BCORL1_ENST00000218147.7_Missense_Mutation_p.Q1585H	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1585					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GCTCAGATCAAGAAGGAGACG	0.498000													60	117					0	0	0.003610	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587121	42587121	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:42587121C>A	ENST00000289957.2	+	5	799	c.671C>A	c.(670-672)aCg>aAg	p.T224K		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	224					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CCCTTTATCACGTATTCCTTC	0.468000													20	34					4.96729e-08	7.07324e-08	0.008871	1	0
DGKK	139189	broad.mit.edu	37	X	50111917	50111917	+	RNA	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:50111917G>C	ENST00000376025.2	-	0	3896							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TCAATGTTGTGAGTTCTTCCA	0.423000													17	36					0	0	0.004007	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880349	74880349	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:74880349G>A	ENST00000289575.5	+	5	975	c.580G>A	c.(580-582)Gtg>Atg	p.V194M	SLCO2B1_ENST00000532236.1_Missense_Mutation_p.V78M|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.V50M|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000428359.2_Missense_Mutation_p.V172M	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	194					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	GATCATGTTCGTGGCACAGAC	0.612000													17	36					0	0	0.004007	0	0
KEL	3792	broad.mit.edu	37	7	142651424	142651424	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:142651424C>A	ENST00000355265.2	-	8	1245	c.771G>T	c.(769-771)ctG>ctT	p.L257L	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	257					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCAAGGTTCCCAGCTGATTCA	0.542000													25	61					2.79863e-10	4.34562e-10	0.004656	1	0
GK	2710	broad.mit.edu	37	X	30714174	30714174	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:30714174G>T	ENST00000378943.3	+	7	747	c.568G>T	c.(568-570)Gtc>Ttc	p.V190F	GK_ENST00000378945.3_Missense_Mutation_p.V190F|GK_ENST00000378946.3_Missense_Mutation_p.V190F|GK_ENST00000427190.1_5'UTR	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	190					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						GACAGGAGGAGTCAATGGAGG	0.363000													4	19					0.000602214	0.000765779	0.000602	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32890646	32890646	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:32890646C>A	ENST00000330048.5	-	0	3152					NR_003083.2																						GCTTGTAGTACACAACGTTGA	0.637000													12	23					2.27111e-07	3.14696e-07	0.001368	1	0
GRHL3	57822	broad.mit.edu	37	1	24658015	24658015	+	Translation_Start_Site	SNP	G	G	A	rs142785065		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:24658015G>A	ENST00000356046.2	+	0	282				GRHL3_ENST00000342072.4_De_novo_Start_InFrame|GRHL3_ENST00000530984.1_3'UTR|GRHL3_ENST00000361548.4_Silent_p.P39P|GRHL3_ENST00000350501.5_Silent_p.P39P|GRHL3_ENST00000236255.4_Silent_p.P44P	NM_001195010.1	NP_001181939.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)						regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TAGAAAACCCGTTGACAGCTG	0.493000													14	70					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9087031	9087031	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:9087031G>T	ENST00000397910.4	-	1	4987	c.4784C>A	c.(4783-4785)aCa>aAa	p.T1595K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1595	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCCCTTGTGTCCCGAGCTC	0.483000													67	39					1.08241e-25	2.20042e-25	0.003610	1	0
ZBTB24	9841	broad.mit.edu	37	6	109787215	109787215	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:109787215G>A	ENST00000230122.3	-	7	2100	c.1933C>T	c.(1933-1935)Ctg>Ttg	p.L645L		NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		AGATGTTCCAGTGTTTCCTTG	0.502000													30	36					0	0	0.002096	0	0
NNT	23530	broad.mit.edu	37	5	43700243	43700243	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:43700243G>T	ENST00000264663.5	+	20	3120	c.2899G>T	c.(2899-2901)Ggc>Tgc	p.G967C	NNT_ENST00000344920.4_Missense_Mutation_p.G967C|NNT_ENST00000512996.2_Missense_Mutation_p.G836C	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	967					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CCCAGTTGCAGGCCGAATGCC	0.458000													24	110					1.17739e-12	1.93518e-12	0.005443	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905810	144905810	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:144905810C>G	ENST00000370490.1	+	1	6122	c.1867C>G	c.(1867-1869)Ctg>Gtg	p.L623V	SLITRK2_ENST00000434188.2_Missense_Mutation_p.L623V|SLITRK2_ENST00000428560.2_Missense_Mutation_p.L623V|SLITRK2_ENST00000413937.2_Missense_Mutation_p.L623V|SLITRK2_ENST00000447897.2_Missense_Mutation_p.L623V			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	623						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCTTAATTCTGGGATTGCT	0.453000													42	62					0	0	0.007835	0	0
DYSF	8291	broad.mit.edu	37	2	71783149	71783149	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:71783149G>T	ENST00000258104.3	+	22	2387	c.2110G>T	c.(2110-2112)Gac>Tac	p.D704Y	DYSF_ENST00000413539.2_Missense_Mutation_p.D735Y|DYSF_ENST00000409582.3_Missense_Mutation_p.D721Y|DYSF_ENST00000410041.1_Missense_Mutation_p.D722Y|DYSF_ENST00000394120.2_Missense_Mutation_p.D705Y|DYSF_ENST00000409651.1_Missense_Mutation_p.D736Y|DYSF_ENST00000409366.1_Missense_Mutation_p.D705Y|DYSF_ENST00000409744.1_Missense_Mutation_p.D691Y|DYSF_ENST00000429174.2_Missense_Mutation_p.D704Y|DYSF_ENST00000409762.1_Missense_Mutation_p.D721Y|DYSF_ENST00000410020.3_Missense_Mutation_p.D722Y	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	704						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CTCCACGGAGGACGTGGACTC	0.662000													3	6					0.004672	0.00572876	0.004672	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	9					0	0	0.002450	0	0
OR2T3	343173	broad.mit.edu	37	1	248637509	248637509	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:248637509C>G	ENST00000359594.2	+	1	883	c.858C>G	c.(856-858)ttC>ttG	p.F286L		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACACCATCTTCACTCCTGTGC	0.502000													63	271					0	0	0.003610	0	0
AMER1	139285	broad.mit.edu	37	X	63410547	63410547	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:63410547C>A	ENST00000330258.3	-	2	2892	c.2620G>T	c.(2620-2622)Gga>Tga	p.G874*	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CCAGGCAGTCCCAAGTATCGA	0.577000													12	23					0.000978159	0.00122866	0.000978	1	0
ZNF534	147658	broad.mit.edu	37	19	52942343	52942343	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:52942343C>G	ENST00000332323.6	+	4	1730	c.1669C>G	c.(1669-1671)Cat>Gat	p.H557D	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Missense_Mutation_p.H544D|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAATGTTCATACTGGAGA	0.438000													5	1					0	0	0.001168	0	0
OR52L1	338751	broad.mit.edu	37	11	6007177	6007177	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:6007177C>A	ENST00000332249.4	-	1	1038	c.984G>T	c.(982-984)aaG>aaT	p.K328N		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	328					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGATCAATCCTTTTGTGTAA	0.488000													4	6					0.000602214	0.000765779	0.000602	1	0
GPRASP2	114928	broad.mit.edu	37	X	101971017	101971017	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:101971017G>C	ENST00000543253.1	+	5	2139	c.1220G>C	c.(1219-1221)tGt>tCt	p.C407S	GPRASP2_ENST00000332262.5_Missense_Mutation_p.C407S|GPRASP2_ENST00000535209.1_Missense_Mutation_p.C407S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TCAGCAATCTGTGAATCTGAG	0.552000													33	68					0	0	0.005524	0	0
MAP7D2	256714	broad.mit.edu	37	X	20043197	20043197	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:20043197C>G	ENST00000379651.3	-	9	1179	c.1161G>C	c.(1159-1161)ttG>ttC	p.L387F	MAP7D2_ENST00000443379.3_Missense_Mutation_p.L342F|MAP7D2_ENST00000379643.5_Missense_Mutation_p.L428F|MAP7D2_ENST00000543767.1_Missense_Mutation_p.L272F|MAP7D2_ENST00000466145.1_5'UTR|MAP7D2_ENST00000452324.3_Missense_Mutation_p.L335F	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	387										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						TGGGCTTCCCCAAGGCTGCAC	0.517000													41	80					0	0	0.006999	0	0
LRP1B	53353	broad.mit.edu	37	2	141108467	141108467	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:141108467G>C	ENST00000389484.3	-	77	12762	c.11791C>G	c.(11791-11793)Caa>Gaa	p.Q3931E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3931					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATCTCTTTGATAATATACA	0.348000										TSP Lung(27;0.18)			10	37					0	0	0.006214	0	0
RNF32	140545	broad.mit.edu	37	7	156450897	156450897	+	Silent	SNP	C	C	A	rs149366944		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:156450897C>A	ENST00000392741.2	+	5	614	c.526C>A	c.(526-528)Cga>Aga	p.R176R	RNF32_ENST00000480011.1_3'UTR|RNF32_ENST00000392743.2_Silent_p.R176R|RNF32_ENST00000317955.5_Silent_p.R176R|RNF32_ENST00000432459.2_Silent_p.R176R|RNF32_ENST00000405335.1_Silent_p.R176R|RNF32_ENST00000311822.8_Silent_p.R176R|RNF32_ENST00000343665.4_Silent_p.R152R			Q9H0A6	RNF32_HUMAN	ring finger protein 32	176						aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GTATCAAACCCGAGTGATACA	0.463000													22	29					1.55795e-14	2.68941e-14	0.001882	1	0
NEUROG2	63973	broad.mit.edu	37	4	113436575	113436575	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:113436575C>A	ENST00000313341.3	-	2	383	c.57G>T	c.(55-57)ctG>ctT	p.L19L	RP11-402J6.1_ENST00000506057.1_RNA	NM_024019.3	NP_076924.1	Q9H2A3	NGN2_HUMAN	neurogenin 2	19					positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			central_nervous_system(1)|large_intestine(3)|lung(6)|skin(2)	12		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		CCGATCCGAGCAGCACTAACA	0.622000													9	33					3.09899e-07	4.27494e-07	0.004482	1	0
MST1L	11223	broad.mit.edu	37	1	17085193	17085193	+	RNA	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:17085193C>T	ENST00000455405.2	-	0	83																											GGATTGATGGCGGCTGGTCAT	0.577000													11	42					0	0	0.001855	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130215645	130215645	+	Silent	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:130215645T>C	ENST00000276211.5	+	2	351	c.6T>C	c.(4-6)ggT>ggC	p.G2G	ARHGAP36_ENST00000370922.1_Intron	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	2					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						CCAGAATGGGTGGCTGCATTC	0.517000													35	47					0	0	0.003755	0	0
HPS6	79803	broad.mit.edu	37	10	103826990	103826990	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:103826990G>A	ENST00000299238.5	+	1	1844	c.1759G>A	c.(1759-1761)Gca>Aca	p.A587T		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	587						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TGTGGAGCTGGCACAGCAGCA	0.662000									Hermansky-Pudlak syndrome				22	33					0	0	0.001523	0	0
NOA1	84273	broad.mit.edu	37	4	57843074	57843074	+	Silent	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:57843074C>G	ENST00000264230.4	-	1	1915	c.678G>C	c.(676-678)ctG>ctC	p.L226L		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	226							GTP binding										GGGCGTCGGGCAGGTCCAGCA	0.697000													14	49					0	0	0.001855	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													5	46					0	0	0.000602	0	0
STAB2	55576	broad.mit.edu	37	12	104033930	104033930	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:104033930G>C	ENST00000388887.2	+	9	1140	c.936G>C	c.(934-936)caG>caC	p.Q312H		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	312					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGCATTACCAGAATTTCGTAC	0.433000													31	52					0	0	0.002096	0	0
TTC8	123016	broad.mit.edu	37	14	89341421	89341421	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:89341421C>T	ENST00000338104.6	+	14	1499	c.1447C>T	c.(1447-1449)Ccg>Tcg	p.P483S	TTC8_ENST00000345383.5_Missense_Mutation_p.P457S|TTC8_ENST00000358622.5_Missense_Mutation_p.P269S|TTC8_ENST00000346301.4_Missense_Mutation_p.P427S|TTC8_ENST00000380656.2_Missense_Mutation_p.P467S|TTC8_ENST00000536576.1_Missense_Mutation_p.P228S|TTC8_ENST00000354441.6_Missense_Mutation_p.P202S			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	493					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						TATGTATGAACCGCATTTTAA	0.299000													21	37					0	0	0.002299	0	0
NR2E1	7101	broad.mit.edu	37	6	108502054	108502054	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:108502054C>A	ENST00000368986.4	+	7	1491	c.783C>A	c.(781-783)atC>atA	p.I261I	NR2E1_ENST00000368983.3_Silent_p.I298I	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	261	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TGAACAAGATCATATCTGAAA	0.373000													24	77					1.96895e-08	2.88344e-08	0.002780	1	0
TP53	7157	broad.mit.edu	37	17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:7578455C>G	ENST00000420246.2	-	5	607	c.475G>C	c.(475-477)Gcc>Ccc	p.A159P	TP53_ENST00000413465.2_Missense_Mutation_p.A159P|TP53_ENST00000455263.2_Missense_Mutation_p.A159P|TP53_ENST00000359597.4_Missense_Mutation_p.A159P|TP53_ENST00000269305.4_Missense_Mutation_p.A159P|TP53_ENST00000445888.2_Missense_Mutation_p.A159P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	159	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159P(19)|p.0?(8)|p.A159T(7)|p.R158fs(6)|p.R158fs*11(6)|p.A159fs*11(4)|p.A159S(4)|p.R65fs(2)|p.A27P(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R26fs(2)|p.A66P(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	14					0	0	0.003954	0	0
FCGBP	8857	broad.mit.edu	37	19	40367787	40367787	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:40367787G>A	ENST00000221347.6	-	29	13180	c.13173C>T	c.(13171-13173)tgC>tgT	p.C4391C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4391	TIL 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AACCCGCGTCGCACTGGCAGC	0.647000													19	56					0	0	0.003954	0	0
FHL5	9457	broad.mit.edu	37	6	97063586	97063586	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:97063586C>T	ENST00000326771.2	+	7	1173	c.793C>T	c.(793-795)Ctg>Ttg	p.L265L	FHL5_ENST00000541107.1_Silent_p.L265L	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	265	LIM zinc-binding 4.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TAAAGGCTTCCTGACCCAGAA	0.483000													12	40					0	0	0.002450	0	0
ZNF678	339500	broad.mit.edu	37	1	227843408	227843408	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:227843408A>G	ENST00000343776.4	+	4	1802	c.1457A>G	c.(1456-1458)gAg>gGg	p.E486G	ZNF678_ENST00000498759.1_Intron|ZNF678_ENST00000397097.3_Missense_Mutation_p.E541G			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	541					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				CATACTGGAGAGAAACGCTAC	0.358000													17	36					0	0	0.004007	0	0
GRB14	2888	broad.mit.edu	37	2	165353575	165353575	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:165353575T>C	ENST00000263915.3	-	12	1863	c.1325A>G	c.(1324-1326)cAc>cGc	p.H442R	GRB14_ENST00000543549.1_Missense_Mutation_p.H355R	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	442	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						AGAAATTTTGTGGTGAAACCA	0.388000													6	29					0	0	0.004482	0	0
TM4SF4	7104	broad.mit.edu	37	3	149193609	149193609	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:149193609G>T	ENST00000305354.4	+	2	1078		c.e2-1			NM_004617.3	NP_004608.1	P48230	T4S4_HUMAN	transmembrane 4 L six family member 4							integral to membrane				large_intestine(3)|lung(4)|ovary(1)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TCTCCTGGTAGATGATCTTCC	0.572000													7	15					2.7689e-08	4.0358e-08	0.001984	1	0
CHRNA6	8973	broad.mit.edu	37	8	42611537	42611537	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:42611537C>T	ENST00000276410.2	-	5	1160	c.805G>A	c.(805-807)Ggt>Agt	p.G269S	CHRNA6_ENST00000534622.1_Missense_Mutation_p.G254S	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	269						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ACTTTTTCACCACAGTCCGAA	0.423000													19	31					0	0	0.006122	0	0
LPAR1	1902	broad.mit.edu	37	9	113637828	113637828	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:113637828C>G	ENST00000374431.3	-	5	1351	c.968G>C	c.(967-969)aGg>aCg	p.R323T	LPAR1_ENST00000541779.1_Missense_Mutation_p.R324T|LPAR1_ENST00000374430.2_Missense_Mutation_p.R323T|LPAR1_ENST00000538760.1_Missense_Mutation_p.R324T|LPAR1_ENST00000358883.4_Missense_Mutation_p.R323T	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	323					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						GAGGATCTGCCTAAAGGTGGC	0.547000													52	22					0	0	0.003610	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834498	101834498	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:101834498C>A	ENST00000506729.1	-	1	222	c.51G>T	c.(49-51)agG>agT	p.R17S	SLCO6A1_ENST00000389019.3_Missense_Mutation_p.R17S|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.R17S|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.R17S|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.R17S			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	17						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCTCTACTCCCCTTGAGACTT	0.677000													54	84					2.84144e-21	5.52204e-21	0.003610	1	0
ALPK2	115701	broad.mit.edu	37	18	56274588	56274588	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:56274588C>G	ENST00000361673.3	-	3	406	c.193G>C	c.(193-195)Gag>Cag	p.E65Q		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	65	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TACTGATTCTCAAAGAATTCA	0.393000													3	44					0	0	0.004672	0	0
LAMB4	22798	broad.mit.edu	37	7	107746332	107746332	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:107746332C>A	ENST00000388781.3	-	8	883	c.800G>T	c.(799-801)tGc>tTc	p.C267F	LAMB4_ENST00000205386.4_Missense_Mutation_p.C267F|LAMB4_ENST00000414450.2_Missense_Mutation_p.C267F|LAMB4_ENST00000388780.3_Missense_Mutation_p.C267F	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	267	Laminin EGF-like 1.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						ATGGCCATTGCAAAAGCAGCT	0.478000													25	33					5.45727e-16	9.58123e-16	0.008361	1	0
HNRNPH2	3188	broad.mit.edu	37	X	100667052	100667052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:100667052G>T	ENST00000316594.5	+	2	154	c.76G>T	c.(76-78)Gaa>Taa	p.E26*	RPL36A-HNRNPH2_ENST00000409170.3_3'UTR	NM_001032393.2|NM_001199973.1|NM_001199974.1|NM_019597.4	NP_001027565.1|NP_001186902.1|NP_001186903.1|NP_062543.1	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2 (H')	26	RRM 1.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(3)|large_intestine(2)|lung(6)|skin(1)	12						CTCAGCCGATGAAGTGATGCG	0.527000													19	82					1.67942e-08	2.47114e-08	0.006122	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75924769	75924769	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:75924769G>T	ENST00000262207.4	+	3	828	c.360G>T	c.(358-360)ttG>ttT	p.L120F	CRISPLD1_ENST00000519798.1_3'UTR|CRISPLD1_ENST00000523524.1_5'UTR|CRISPLD1_ENST00000517786.1_5'UTR	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	120						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GACAGAATTTGGGAGCACACT	0.388000													25	29					2.52088e-20	4.7497e-20	0.002780	1	0
HBBP1	3044	broad.mit.edu	37	11	5264337	5264337	+	RNA	SNP	A	A	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5264337A>C	ENST00000454892.1	-	0	159					NR_001589.1																						ACTACTCACCAGGAAGTTCTC	0.458000													4	14					0	0	0.000248	0	0
THEM5	284486	broad.mit.edu	37	1	151820257	151820257	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:151820257G>T	ENST00000368817.5	-	5	788	c.657C>A	c.(655-657)atC>atA	p.I219I	AL450992.2_ENST00000434182.1_RNA	NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	219							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCTGTGGGCGATGCAGGACA	0.582000													18	41					4.35082e-09	6.4947e-09	0.001523	1	0
MRM1	79922	broad.mit.edu	37	17	34958541	34958541	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:34958541G>A	ENST00000250156.7	+	1	541	c.302G>A	c.(301-303)cGg>cAg	p.R101Q	MRM1_ENST00000585770.1_5'UTR	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	101					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCAGTTCTGCGGCCCAGACGG	0.687000													24	29					0	0	0.003954	0	0
ALMS1P	200420	broad.mit.edu	37	2	73899935	73899935	+	RNA	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:73899935G>C	ENST00000450720.1	+	0	495					NR_003683.2																						TTTCCTGTAGGAGTTTCCTGG	0.423000													7	15					0	0	0.003080	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427643	25427643	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:25427643C>A	ENST00000424208.1	+	0	272					NR_003305.1																						GAAGAGGATGCTGGGATTCCG	0.522000													53	36					3.4597e-24	6.85287e-24	0.003610	1	0
CDH12	1010	broad.mit.edu	37	5	22078729	22078729	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:22078729G>A	ENST00000382254.1	-	5	1143	c.57C>T	c.(55-57)ctC>ctT	p.L19L	CDH12_ENST00000522262.1_Silent_p.L19L|CDH12_ENST00000504376.2_Silent_p.L19L	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	19					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						GTGGTGTTAGGAGACCTCCAT	0.453000										HNSCC(59;0.17)			33	225					0	0	0.002445	0	0
IGHV3-48	28424	broad.mit.edu	37	14	106993928	106993928	+	RNA	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:106993928G>T	ENST00000390624.2	-	0	315																											CAGAGTCTGCGTAGTATATGG	0.502000													35	293					2.42023e-17	4.32284e-17	0.003271	1	0
DSP	1832	broad.mit.edu	37	6	7580653	7580653	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:7580653G>A	ENST00000379802.3	+	23	4571	c.4230G>A	c.(4228-4230)aaG>aaA	p.K1410K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1410	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAGAAATAAAGAGGCTGAAGA	0.502000													22	27					0	0	0.001523	0	0
SLC25A53	401612	broad.mit.edu	37	X	103349839	103349839	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:103349839C>A	ENST00000357421.4	-	2	282	c.102G>T	c.(100-102)ggG>ggT	p.G34G		NM_001012755.3	NP_001012773.2	Q5H9E4	MCAR6_HUMAN	solute carrier family 25, member 53	34					transport	integral to membrane|mitochondrial inner membrane											TGGAAACGGCCCCAAGGGCAT	0.542000													10	55					0.000442599	0.000572231	0.006214	1	0
TMTC3	160418	broad.mit.edu	37	12	88548081	88548081	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:88548081G>T	ENST00000266712.6	+	4	645	c.425G>T	c.(424-426)gGa>gTa	p.G142V		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	142						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						GGAGTTGTTGGAAGAGCAGAA	0.299000													17	20					1.02788e-11	1.64568e-11	0.004990	1	0
BTBD11	121551	broad.mit.edu	37	12	107937911	107937911	+	Silent	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:107937911G>C	ENST00000280758.5	+	3	2013	c.1485G>C	c.(1483-1485)gtG>gtC	p.V495V	BTBD11_ENST00000420571.2_Silent_p.V495V|BTBD11_ENST00000490090.2_Silent_p.V495V	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	495						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						ACCTCCAGGTGGAAAGGTAAG	0.567000													13	20					0	0	0.001855	0	0
KCNH2	3757	broad.mit.edu	37	7	150647303	150647303	+	Missense_Mutation	SNP	C	C	A	rs149588350		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:150647303C>A	ENST00000392968.2	-	7	3183	c.2063G>T	c.(2062-2064)cGg>cTg	p.R688L	KCNH2_ENST00000430723.3_Missense_Mutation_p.R784L|KCNH2_ENST00000262186.5_Missense_Mutation_p.R784L|KCNH2_ENST00000330883.4_Missense_Mutation_p.R444L			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	784					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GATGGAGCCCCGGGAGATGAA	0.647000													28	57					3.73148e-12	6.00535e-12	0.007291	1	0
STRN	6801	broad.mit.edu	37	2	37132762	37132762	+	Splice_Site	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:37132762C>A	ENST00000263918.4	-	4	421		c.e4-1		STRN_ENST00000379213.2_Splice_Site	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein						dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTACCTTCATCTAGAAAACAT	0.333000													11	48					2.80697e-09	4.21046e-09	0.000978	1	0
OR4C6	219432	broad.mit.edu	37	11	55433305	55433305	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:55433305C>A	ENST00000314259.3	+	1	692	c.663C>A	c.(661-663)tgC>tgA	p.C221*		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TCATCCTATGCTCCCTGAAGT	0.507000													29	53					1.75199e-13	2.94219e-13	0.007291	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	9					1.05317e-09	1.59524e-09	0.002450	1	0
DMD	1756	broad.mit.edu	37	X	32490369	32490369	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:32490369C>A	ENST00000357033.4	-	22	3067	c.2861G>T	c.(2860-2862)tGg>tTg	p.W954L	DMD_ENST00000378677.2_Missense_Mutation_p.W950L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	954					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGCTGGACCCATGTCCTGAT	0.428000													23	35					6.21321e-17	1.10338e-16	0.002780	1	0
CAMTA1	23261	broad.mit.edu	37	1	7723976	7723976	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:7723976C>T	ENST00000303635.7	+	9	1576	c.1369C>T	c.(1369-1371)Ccc>Tcc	p.P457S	CAMTA1_ENST00000439411.2_Missense_Mutation_p.P457S	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GTCCATGCTGCCCACCAACGT	0.607000			T	WWTR1	epitheliod hemangioendothelioma								11	83					0	0	0.008291	0	0
OR51I2	390064	broad.mit.edu	37	11	5474928	5474928	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5474928T>A	ENST00000341449.2	+	1	291	c.210T>A	c.(208-210)gaT>gaA	p.D70E	HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTTCAGTGATGTGGCCATAT	0.522000													20	52					0	0	0.008871	0	0
STXBP6	29091	broad.mit.edu	37	14	25326295	25326295	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:25326295C>A	ENST00000323944.5	-	3	674	c.223G>T	c.(223-225)Gtt>Ttt	p.V75F	STXBP6_ENST00000358326.2_Missense_Mutation_p.V75F|STXBP6_ENST00000550887.1_Missense_Mutation_p.V75F|STXBP6_ENST00000419632.2_Missense_Mutation_p.V75F|STXBP6_ENST00000548724.1_Missense_Mutation_p.V75F|STXBP6_ENST00000396700.1_Missense_Mutation_p.V75F|STXBP6_ENST00000546511.1_Missense_Mutation_p.V75F			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	75					vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		GATCTCCGAACAAATGATGTG	0.463000													45	78					9.84934e-19	1.81157e-18	0.002522	1	0
TRPM6	140803	broad.mit.edu	37	9	77403579	77403579	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:77403579C>A	ENST00000451710.3	-	20	2855	c.2618G>T	c.(2617-2619)tGg>tTg	p.W873L	TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.W868L|TRPM6_ENST00000376864.4_Missense_Mutation_p.W873L|TRPM6_ENST00000360774.1_Missense_Mutation_p.W873L|TRPM6_ENST00000449912.2_Missense_Mutation_p.W868L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	873					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GCTAACAAGCCACTCCTGCAC	0.498000													38	13					5.43694e-19	1.006e-18	0.005524	1	0
TTN	7273	broad.mit.edu	37	2	179425863	179425863	+	Silent	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:179425863A>G	ENST00000589042.1	-	326	85220	c.84996T>C	c.(84994-84996)gcT>gcC	p.A28332A	TTN_ENST00000359218.5_Silent_p.A19392A|TTN_ENST00000342175.6_Silent_p.A19459A|TTN_ENST00000342992.6_Silent_p.A25764A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.A19267A|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.A26691A|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26691	Fibronectin type-III 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGTCAGCAGCATTCCTTG	0.403000													22	64					0	0	0.001882	0	0
MAP2K7	5609	broad.mit.edu	37	19	7975916	7975916	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:7975916G>T	ENST00000545011.1	+	7	918	c.853G>T	c.(853-855)Gac>Tac	p.D285Y	MAP2K7_ENST00000397979.3_Missense_Mutation_p.D243Y|MAP2K7_ENST00000397981.3_Missense_Mutation_p.D243Y|MAP2K7_ENST00000397983.3_Missense_Mutation_p.D259Y			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	243	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	CATCCACCGCGACGTCAAGCC	0.632000													20	10					2.4624e-09	3.71161e-09	0.008871	1	0
SLC26A2	1836	broad.mit.edu	37	5	149357882	149357882	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:149357882A>C	ENST00000286298.4	+	2	935	c.667A>C	c.(667-669)Agc>Cgc	p.S223R		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	223						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TATGGTTGGCAGCACTGTAAC	0.353000													32	26					0	0	0.002836	0	0
RNMT	8731	broad.mit.edu	37	18	13737099	13737099	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:13737099G>A	ENST00000383314.2	+	5	884	c.644G>A	c.(643-645)tGg>tAg	p.W215*	RNMT_ENST00000262173.3_Nonsense_Mutation_p.W215*|RNMT_ENST00000592764.1_Nonsense_Mutation_p.W215*|RNMT_ENST00000589866.1_Nonsense_Mutation_p.W215*|RNMT_ENST00000535051.1_5'UTR|RNMT_ENST00000543302.2_Nonsense_Mutation_p.W215*			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	215					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						TTGCTGAAATGGAAAAAAGGA	0.328000													13	22					0	0	0.003163	0	0
WDR96	80217	broad.mit.edu	37	10	105944862	105944862	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:105944862C>G	ENST00000357060.3	-	16	2168	c.2053G>C	c.(2053-2055)Ggg>Cgg	p.G685R	WDR96_ENST00000278064.2_Missense_Mutation_p.G616R|WDR96_ENST00000428666.1_Missense_Mutation_p.G686R	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	685										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GACTGAATCCCATGACCCTGG	0.403000													3	51					0	0	0.004672	0	0
SIX2	10736	broad.mit.edu	37	2	45233362	45233362	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:45233362G>T	ENST00000303077.6	-	2	1142	c.823C>A	c.(823-825)Cag>Aag	p.Q275K		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	275						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATGGAGTCCTGCAGGCCATGG	0.642000													9	80					2.52707e-12	4.10981e-12	0.006214	1	0
RP11-252A24.2	0	broad.mit.edu	37	16	74394620	74394620	+	RNA	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:74394620G>A	ENST00000429810.2	-	0	345																											CTCCACAGACGACCACCTGTG	0.582000													22	43					0	0	0.002299	0	0
LAMC3	10319	broad.mit.edu	37	9	133920910	133920910	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:133920910G>T	ENST00000361069.4	+	8	1515		c.e8-1		LAMC3_ENST00000480883.1_Splice_Site	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3						cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCCATTTCAGATGTCGCCCG	0.607000													11	38					3.27435e-08	4.70593e-08	0.002450	1	0
USP40	55230	broad.mit.edu	37	2	234436148	234436148	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:234436148C>A	ENST00000251722.6	-	13	1744	c.1627G>T	c.(1627-1629)Gct>Tct	p.A543S	USP40_ENST00000450966.1_Missense_Mutation_p.A555S|USP40_ENST00000427112.2_Missense_Mutation_p.A543S			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	543					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		GGGTGCAGAGCCCCATTGAAG	0.403000													15	15					1.67942e-08	2.47114e-08	0.006122	1	0
CYCS	54205	broad.mit.edu	37	7	25163735	25163735	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:25163735C>G	ENST00000305786.2	-	2	173	c.4G>C	c.(4-6)Ggt>Cgt	p.G2R	CYCS_ENST00000409764.1_Missense_Mutation_p.G2R|CYCS_ENST00000409409.1_Missense_Mutation_p.G2R	NM_018947.5	NP_061820.1	P99999	CYC_HUMAN	cytochrome c, somatic	2					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			endometrium(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	4					Melatonin(DB01065)|Minocycline(DB01017)	TCAACATCACCCATATTTAAT	0.383000													5	41					0	0	0.001168	0	0
STS	412	broad.mit.edu	37	X	7177623	7177623	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:7177623G>A	ENST00000217961.4	+	5	851	c.631G>A	c.(631-633)Gtg>Atg	p.V211M		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	211					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GCTACTCCACGTGCCTCTAGG	0.552000									Ichthyosis				18	77					0	0	0.008871	0	0
ANO1	55107	broad.mit.edu	37	11	69972201	69972201	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:69972201G>C	ENST00000355303.5	+	10	1302	c.997G>C	c.(997-999)Gcc>Ccc	p.A333P	ANO1_ENST00000531349.1_Missense_Mutation_p.A68P|ANO1_ENST00000538023.1_Missense_Mutation_p.A333P|ANO1_ENST00000316296.5_Missense_Mutation_p.A305P|ANO1_ENST00000398543.2_Missense_Mutation_p.A217P|ANO1_ENST00000530676.1_Missense_Mutation_p.A217P	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	333					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						CCTGTACTTCGCCTGGCTGGG	0.537000													20	39					0	0	0.002299	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324854	150324854	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:150324854C>T	ENST00000328902.5	-	3	1048	c.832G>A	c.(832-834)Gaa>Aaa	p.E278K	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	278							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTCAGATTCCTTCTGGATC	0.572000													16	62					0	0	0.004007	0	0
KCNB2	9312	broad.mit.edu	37	8	73480446	73480446	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:73480446G>T	ENST00000523207.1	+	2	1065	c.477G>T	c.(475-477)atG>atT	p.M159I		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	159					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAGAGACTATGCGAGAGCGAG	0.468000													39	56					2.35958e-20	4.47308e-20	0.002222	1	0
OTC	5009	broad.mit.edu	37	X	38268137	38268137	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:38268137C>A	ENST00000039007.4	+	8	878	c.726C>A	c.(724-726)acC>acA	p.T242T	TM4SF2_ENST00000465127.1_Intron	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	242			T -> I (in OTCD; late onset).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	AGAATGGTACCAAGCTGTTGC	0.393000													19	55					1.67942e-08	2.47114e-08	0.006122	1	0
LRRC7	57554	broad.mit.edu	37	1	70300548	70300548	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:70300548G>C	ENST00000310961.5	+	7	905	c.487G>C	c.(487-489)Gga>Cga	p.G163R	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000370958.1_Missense_Mutation_p.G196R|LRRC7_ENST00000035383.5_Missense_Mutation_p.G158R			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	158						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGCCAATTTTGGAAGGTAAGA	0.388000													17	32					0	0	0.004990	0	0
COL6A5	256076	broad.mit.edu	37	3	130159301	130159301	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:130159301T>A	ENST00000265379.6	+	35	6613	c.6119T>A	c.(6118-6120)cTa>cAa	p.L2040Q	COL6A5_ENST00000432398.2_Missense_Mutation_p.L2040Q			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2040	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						AACCAACTCCTAATGAAGAAT	0.408000													14	67					0	0	0.003163	0	0
OR8D2	283160	broad.mit.edu	37	11	124189303	124189303	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:124189303G>T	ENST00000357438.2	-	1	881	c.791C>A	c.(790-792)tCc>tAc	p.S264Y		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AGTAGTGCTGGAAGGGGGCTT	0.448000													35	72					1.04594e-18	1.9124e-18	0.006230	1	0
MC1R	4157	broad.mit.edu	37	16	89985766	89985766	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:89985766C>T	ENST00000555427.1	+	3	2403	c.100C>T	c.(100-102)Cgg>Tgg	p.R34W	TUBB3_ENST00000556922.1_Missense_Mutation_p.R34W|MC1R_ENST00000555147.1_Missense_Mutation_p.R34W					melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GACAGGAGCCCGGTGCCTGGA	0.647000									Melanoma, Familial Clustering of				3	27					0	0	0.004672	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904663	144904663	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:144904663G>A	ENST00000370490.1	+	1	4975	c.720G>A	c.(718-720)gaG>gaA	p.E240E	SLITRK2_ENST00000434188.2_Silent_p.E240E|SLITRK2_ENST00000428560.2_Silent_p.E240E|SLITRK2_ENST00000413937.2_Silent_p.E240E|SLITRK2_ENST00000447897.2_Silent_p.E240E			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	240	LRRCT 1.					integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTGGGAGAGATTGTCTGTG	0.488000													42	85					0	0	0.006999	0	0
DDIT4	54541	broad.mit.edu	37	10	74034719	74034719	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:74034719C>T	ENST00000307365.3	+	3	673	c.472C>T	c.(472-474)Cac>Tac	p.H158Y	RP11-442H21.2_ENST00000491934.2_RNA	NM_019058.2	NP_061931.1	Q9NX09	DDIT4_HUMAN	DNA-damage-inducible transcript 4	158					apoptosis					cervix(1)|endometrium(2)|lung(5)|pancreas(1)|prostate(2)|urinary_tract(1)	12						CAAGAGCTGCCACAGCGTGGG	0.687000											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0.006214	0	0
PANX1	24145	broad.mit.edu	37	11	93913424	93913424	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:93913424G>T	ENST00000227638.3	+	4	1586		c.e4+1		PANX1_ENST00000436171.2_Splice_Site	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1						positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAGCTCCAAGGTAGGGTTTGC	0.507000													3	20					0.00024832	0.000323759	0.000248	1	0
SPATA31A6	389730	broad.mit.edu	37	9	43627331	43627331	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:43627331A>T	ENST00000332857.6	-	4	1384	c.1356T>A	c.(1354-1356)aaT>aaA	p.N452K		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TTGGGCAGACATTGGACATTT	0.517000													21	469					0	0	0.002299	0	0
FOXO1	2308	broad.mit.edu	37	13	41134854	41134854	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr13:41134854G>A	ENST00000379561.5	-	2	1158	c.774C>T	c.(772-774)gaC>gaT	p.D258D		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	258					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TACTGTTGTTGTCCATGGATG	0.522000													48	27					0	0	0.003610	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736223	140736223	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:140736223C>T	ENST00000571252.1	+	1	1456	c.1456C>T	c.(1456-1458)Cga>Tga	p.R486*	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACAATGCCCGAATCACTTA	0.507000													37	113					0	0	0.004289	0	0
OTOP1	133060	broad.mit.edu	37	4	4214688	4214688	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:4214688G>T	ENST00000296358.4	-	2	471	c.447C>A	c.(445-447)tgC>tgA	p.C149*		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	149					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CAATTTTAAGGCATCCCAGGA	0.408000													6	16					3.59834e-05	4.81336e-05	0.001168	1	0
NKTR	4820	broad.mit.edu	37	3	42685392	42685392	+	Splice_Site	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:42685392A>T	ENST00000232978.8	+	16	4387		c.e16-1		RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence						protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CCGTTAAAGCAGGTCCTACAC	0.443000													12	18					0	0	0.001368	0	0
SLC38A9	153129	broad.mit.edu	37	5	54968503	54968503	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:54968503G>C	ENST00000539768.1	-	2	133	c.134C>G	c.(133-135)aCa>aGa	p.T45R	SLC38A9_ENST00000515629.1_5'UTR|SLC38A9_ENST00000396865.2_Missense_Mutation_p.T45R|SLC38A9_ENST00000318672.3_Missense_Mutation_p.T45R|SLC38A9_ENST00000512595.1_Missense_Mutation_p.T18R|SLC38A9_ENST00000416547.2_Intron			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	45					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				CACGATGTTTGTGGGCTCTAT	0.418000													3	42					0	0	0.004672	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													4	57					0	0	0.000248	0	0
KIAA1210	57481	broad.mit.edu	37	X	118250553	118250553	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:118250553G>T	ENST00000402510.2	-	4	555	c.556C>A	c.(556-558)Cag>Aag	p.Q186K		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	186										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TCTTCTTCCTGGGTATCTTCG	0.418000													9	21					0.00448238	0.00551815	0.004482	1	0
EPB41L4A	64097	broad.mit.edu	37	5	111595633	111595633	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:111595633C>A	ENST00000261486.5	-	8	962	c.686G>T	c.(685-687)gGt>gTt	p.G229V		NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	229	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CACAACAACACCAACCGGAGT	0.378000													13	15					0.00010058	0.000132817	0.001368	1	0
TTK	7272	broad.mit.edu	37	6	80744812	80744812	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:80744812G>C	ENST00000509894.1	+	15	2551	c.1722G>C	c.(1720-1722)ttG>ttC	p.L574F	TTK_ENST00000230510.3_Missense_Mutation_p.L574F|TTK_ENST00000369798.2_Missense_Mutation_p.L575F			P33981	TTK_HUMAN	TTK protein kinase	575	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TAGCTTATTTGAATAAACTAC	0.279000													15	52					0	0	0.004990	0	0
EMR2	30817	broad.mit.edu	37	19	14865885	14865885	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:14865885C>A	ENST00000315576.3	-	14	1922	c.1471G>T	c.(1471-1473)Gga>Tga	p.G491*	EMR2_ENST00000596991.2_Nonsense_Mutation_p.G480*|EMR2_ENST00000353005.1_Nonsense_Mutation_p.G349*|EMR2_ENST00000392964.3_Missense_Mutation_p.W155L|EMR2_ENST00000392967.2_Nonsense_Mutation_p.G480*|EMR2_ENST00000601345.1_Nonsense_Mutation_p.G480*|EMR2_ENST00000594076.1_Nonsense_Mutation_p.G398*|EMR2_ENST00000346057.1_Nonsense_Mutation_p.G442*|EMR2_ENST00000594294.1_Nonsense_Mutation_p.G442*|EMR2_ENST00000595839.1_Nonsense_Mutation_p.G349*|EMR2_ENST00000353876.1_Nonsense_Mutation_p.G398*|EMR2_ENST00000392965.3_Intron	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	491	GPS.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						TGACCACATCCATTCTGGCCA	0.592000													36	16					2.05212e-20	3.91423e-20	0.005524	1	0
MTMR8	55613	broad.mit.edu	37	X	63569937	63569937	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:63569937T>C	ENST00000374852.3	-	5	549	c.482A>G	c.(481-483)tAc>tGc	p.Y161C	MTMR8_ENST00000453546.1_Missense_Mutation_p.Y161C	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	161	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TTCAGGAGGGTAGGTGCTGCA	0.353000													25	52					0	0	0.005443	0	0
TLR2	7097	broad.mit.edu	37	4	154625452	154625452	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:154625452A>T	ENST00000260010.6	+	1	2801	c.1393A>T	c.(1393-1395)Agc>Tgc	p.S465C		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	465					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TTTAGATGTTAGCAACAACAA	0.368000													34	27					0	0	0.003271	0	0
VWF	7450	broad.mit.edu	37	12	6127901	6127901	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:6127901G>T	ENST00000261405.5	-	28	4937	c.4683C>A	c.(4681-4683)atC>atA	p.I1561I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1561	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CCCGCTGCAGGATGTCCCCTT	0.617000													17	10					4.96729e-08	7.07324e-08	0.008871	1	0
RPL6	6128	broad.mit.edu	37	12	112843710	112843710	+	Missense_Mutation	SNP	T	T	G	rs148929822	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:112843710T>G	ENST00000424576.2	-	6	846	c.661A>C	c.(661-663)Aag>Cag	p.K221Q	RPL6_ENST00000202773.9_Missense_Mutation_p.K221Q	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	221					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome	p.K221Q(1)		cervix(1)|large_intestine(6)|lung(3)	10						TTCCGCAGCTTCTTCTTCTTG	0.423000													14	37					0	0	0.002450	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52926859	52926859	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52926859C>A	ENST00000371544.3	-	19	3530	c.3268G>T	c.(3268-3270)Gct>Tct	p.A1090S	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.A1090S	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1090					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GGATCAATAGCTGCATAAGTA	0.279000													37	43					1.15183e-24	2.31114e-24	0.002222	1	0
MC5R	4161	broad.mit.edu	37	18	13826520	13826520	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr18:13826520C>A	ENST00000324750.3	+	1	978	c.756C>A	c.(754-756)gcC>gcA	p.A252A		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	252					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						TGTGCTGGGCCCCGTTCTTCC	0.572000													26	94					9.57634e-11	1.51748e-10	0.003330	1	0
SYT9	143425	broad.mit.edu	37	11	7441778	7441778	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:7441778A>T	ENST00000318881.6	+	6	1616	c.1379A>T	c.(1378-1380)aAc>aTc	p.N460I		NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	460						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAAGTAGGCAACGAGGCTGAG	0.463000													8	15					0	0	0.003080	0	0
ARID1B	57492	broad.mit.edu	37	6	157521999	157521999	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:157521999C>T	ENST00000346085.5	+	18	4272	c.4271C>T	c.(4270-4272)cCg>cTg	p.P1424L	ARID1B_ENST00000367148.1_Missense_Mutation_p.P1464L|ARID1B_ENST00000350026.5_Missense_Mutation_p.P1411L|ARID1B_ENST00000275248.4_Missense_Mutation_p.P1406L	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1411					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GGCCAGTACCCGTATCCCTAC	0.627000													4	33					0	0	0.000602	0	0
TRBV5-6	28609	broad.mit.edu	37	7	142131873	142131873	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:142131873C>A	ENST00000390375.2	-	0	45																											GAGCCCGGGGCCCATGGCACA	0.607000													20	40					8.10497e-08	1.14882e-07	0.001523	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73148902	73148902	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:73148902T>G	ENST00000286657.4	-	22	3605	c.3569A>C	c.(3568-3570)aAg>aCg	p.K1190T		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	1190					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCAATGATCTTTCCATCTTT	0.448000													11	77					0	0	0.001368	0	0
OR52L1	338751	broad.mit.edu	37	11	6007176	6007176	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:6007176C>A	ENST00000332249.4	-	1	1039	c.985G>T	c.(985-987)Gat>Tat	p.D329Y		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	329					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGATCAATCCTTTTGTGTA	0.483000													4	6					0.000602214	0.000765779	0.000602	1	0
PDZRN4	29951	broad.mit.edu	37	12	41967321	41967321	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:41967321C>A	ENST00000298919.7	+	10	2348	c.1960C>A	c.(1960-1962)Cgt>Agt	p.R654S	PDZRN4_ENST00000402685.2_Missense_Mutation_p.R914S|PDZRN4_ENST00000539469.2_Missense_Mutation_p.R656S			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	914							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CCTGAAGGAACGTGCCTTAAA	0.512000													24	48					3.08376e-08	4.47363e-08	0.003330	1	0
PTPRN	5798	broad.mit.edu	37	2	220161970	220161970	+	Silent	SNP	C	C	A	rs145338513	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:220161970C>A	ENST00000295718.2	-	14	2313	c.2073G>T	c.(2071-2073)acG>acT	p.T691T	PTPRN_ENST00000423636.2_Silent_p.T601T|PTPRN_ENST00000409251.3_Silent_p.T662T	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	691					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCATGTGTCCCGTGGAGATGT	0.662000													22	27					1.28384e-07	1.80321e-07	0.001882	1	0
CFAP54	144535	broad.mit.edu	37	12	97043823	97043823	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:97043823A>T	ENST00000524981.3	+	2	198	c.198A>T	c.(196-198)aaA>aaT	p.K66N				Q6ZTY8	CL063_HUMAN		40										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						ATTTTATGAAAATCTTTTTAT	0.378000													15	26					0	0	0.002450	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264024	140264024	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:140264024C>T	ENST00000289272.2	+	1	2171	c.2171C>T	c.(2170-2172)tCg>tTg	p.S724L	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.S724L|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGGTGCTCGGCACCGCCC	0.657000													21	76					0	0	0.003954	0	0
ZNF85	7639	broad.mit.edu	37	19	21131729	21131729	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:21131729T>C	ENST00000601023.1	+	2	878	c.232T>C	c.(232-234)Tgt>Cgt	p.C78R	ZNF85_ENST00000345030.6_Missense_Mutation_p.C104R|ZNF85_ENST00000328178.8_Missense_Mutation_p.C137R			Q03923	ZNF85_HUMAN	zinc finger protein 85	137						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						ACTTAACCAATGTCTCACAGC	0.323000													11	46					0	0	0.000978	0	0
RIF1	55183	broad.mit.edu	37	2	152267818	152267818	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:152267818A>T	ENST00000243326.4	+	2	632	c.149A>T	c.(148-150)gAg>gTg	p.E50V	RIF1_ENST00000428287.2_Missense_Mutation_p.E50V|RIF1_ENST00000444746.2_Missense_Mutation_p.E50V|RIF1_ENST00000430328.2_Missense_Mutation_p.E50V|RIF1_ENST00000433166.2_Missense_Mutation_p.E50V|RIF1_ENST00000453091.2_Missense_Mutation_p.E50V			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	50					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ACAGAAATTGAGAAAAAACTT	0.299000													15	25					0	0	0.004007	0	0
CHST4	10164	broad.mit.edu	37	16	71571481	71571481	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:71571481C>T	ENST00000338482.5	+	3	1244	c.901C>T	c.(901-903)Cat>Tat	p.H301Y	CHST4_ENST00000572450.1_Missense_Mutation_p.H301Y|CHST4_ENST00000539698.3_Missense_Mutation_p.H301Y|ZNF19_ENST00000568446.1_Intron|RP11-510M2.9_ENST00000572693.1_RNA			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	301					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						ATTCTTGCCCCATCTTCAGAC	0.562000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	34					0	0	0.004007	0	0
CDH10	1008	broad.mit.edu	37	5	24498613	24498613	+	Missense_Mutation	SNP	G	G	A	rs145457868	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:24498613G>A	ENST00000264463.4	-	9	1916	c.1409C>T	c.(1408-1410)aCa>aTa	p.T470I	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	470	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CACGCGTGTTGTCTCTTTGGG	0.373000										HNSCC(23;0.051)			35	24					0	0	0.004289	0	0
S1PR1	1901	broad.mit.edu	37	1	101704965	101704965	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:101704965G>T	ENST00000305352.6	+	2	800	c.425G>T	c.(424-426)cGc>cTc	p.R142L	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	142					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						GCCATTGAGCGCTATATCACA	0.547000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	86					2.47872e-24	4.94146e-24	0.002522	1	0
FOLH1	2346	broad.mit.edu	37	11	49208288	49208288	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:49208288C>A	ENST00000340334.7	-	6	870	c.502G>T	c.(502-504)Gaa>Taa	p.E168*	FOLH1_ENST00000533034.1_Nonsense_Mutation_p.E168*|FOLH1_ENST00000343844.4_5'UTR|FOLH1_ENST00000356696.3_Nonsense_Mutation_p.E183*|FOLH1_ENST00000256999.2_Nonsense_Mutation_p.E183*	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	183					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAGAAGTCTTCAGTTCGTGCA	0.383000													9	47					0.00448238	0.00551815	0.004482	1	0
GCAT	23464	broad.mit.edu	37	22	38211724	38211724	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:38211724G>C	ENST00000323205.6	+	7	1010	c.947G>C	c.(946-948)cGg>cCg	p.R316P	GCAT_ENST00000248924.6_Missense_Mutation_p.R290P	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	290					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGCGCGCCCGGCCATACCTC	0.642000													49	67					0	0	0.003610	0	0
GALNTL6	442117	broad.mit.edu	37	4	173942643	173942643	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:173942643G>A	ENST00000506823.1	+	12	2162	c.1505G>A	c.(1504-1506)tGg>tAg	p.W502*	GALNTL6_ENST00000508122.1_Nonsense_Mutation_p.W485*	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	502	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.?(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						ACCTTTGGATGGAGAGAAGAT	0.478000													31	43					0	0	0.002836	0	0
CHKA	1119	broad.mit.edu	37	11	67864558	67864558	+	Silent	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:67864558A>T	ENST00000265689.4	-	2	416	c.390T>A	c.(388-390)ccT>ccA	p.P130P	CHKA_ENST00000356135.5_Silent_p.P130P	NM_001277.2	NP_001268.2	P35790	CHKA_HUMAN	choline kinase alpha	130					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13					Choline(DB00122)	CTGTGGTGTCAGGTAGGGAGC	0.512000													16	30					0	0	0.006122	0	0
IQUB	154865	broad.mit.edu	37	7	123152037	123152037	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:123152037C>A	ENST00000466202.1	-	2	934	c.358G>T	c.(358-360)Gaa>Taa	p.E120*	IQUB_ENST00000434450.1_Nonsense_Mutation_p.E120*|IQUB_ENST00000488987.1_Intron|IQUB_ENST00000324698.6_Nonsense_Mutation_p.E120*			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	120										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TGCAAAGATTCCTTTACAGAC	0.353000													13	24					3.27435e-08	4.70593e-08	0.002450	1	0
OR4X1	390113	broad.mit.edu	37	11	48285577	48285577	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:48285577C>T	ENST00000320048.1	+	1	165	c.165C>T	c.(163-165)tcC>tcT	p.S55S		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TGCTCACCTCCCCCATGTATT	0.478000													16	27					0	0	0.006122	0	0
SI	6476	broad.mit.edu	37	3	164727105	164727105	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:164727105A>G	ENST00000264382.3	-	35	4203	c.4141T>C	c.(4141-4143)Ttt>Ctt	p.F1381L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1381	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCATTGTAAAAGTCCACAATT	0.368000										HNSCC(35;0.089)			3	62					0	0	0.004672	0	0
CABS1	85438	broad.mit.edu	37	4	71201618	71201618	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:71201618G>T	ENST00000273936.4	+	1	921	c.862G>T	c.(862-864)Gat>Tat	p.D288Y		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	288						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCTGCTAACTGATGAAGAAAC	0.413000													8	25					9.70103e-10	1.47666e-09	0.008291	1	0
C22orf42	150297	broad.mit.edu	37	22	32546391	32546391	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:32546391A>G	ENST00000382097.3	-	7	641	c.569T>C	c.(568-570)cTa>cCa	p.L190P		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	190										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						AGAGACAGATAGGCTTTCACT	0.438000													39	39					0	0	0.006230	0	0
DCST2	127579	broad.mit.edu	37	1	155006119	155006119	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:155006119G>A	ENST00000368424.3	-	1	117	c.59C>T	c.(58-60)gCg>gTg	p.A20V	DCST2_ENST00000295536.5_Missense_Mutation_p.A20V	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	20						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CACAGCTCTCGCCATGCTAGG	0.602000													28	60					0	0	0.006320	0	0
TTN	7273	broad.mit.edu	37	2	179542483	179542483	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:179542483G>A	ENST00000589042.1	-	146	34380	c.34156C>T	c.(34156-34158)Cct>Tct	p.P11386S	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P10142S|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P11069S|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11069	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCTTCAGGTAGAACTTCC	0.428000													22	81					0	0	0.002780	0	0
HRH2	3274	broad.mit.edu	37	5	175111128	175111128	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:175111128G>A	ENST00000231683.2	+	1	2665	c.892G>A	c.(892-894)Ggg>Agg	p.G298R	HRH2_ENST00000377291.2_Missense_Mutation_p.G298R	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	298					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity	p.G298W(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CTTCCGCACCGGGTACCAACA	0.567000													14	27					0	0	0.001855	0	0
TAF1	6872	broad.mit.edu	37	X	70618499	70618499	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:70618499G>T	ENST00000449580.1	+	24	3746	c.3695G>T	c.(3694-3696)aGg>aTg	p.R1232M	TAF1_ENST00000423759.1_Missense_Mutation_p.R1253M|TAF1_ENST00000373790.4_Missense_Mutation_p.R1232M|TAF1_ENST00000276072.3_Missense_Mutation_p.R1253M			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1232					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GAGCAACTGAGGCGGCTTAAG	0.468000													10	34					0.000978159	0.00122866	0.000978	1	0
CNTN3	5067	broad.mit.edu	37	3	74316416	74316416	+	Splice_Site	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:74316416C>T	ENST00000263665.6	-	20	2845		c.e20+1		CNTN3_ENST00000477856.1_Splice_Site	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)						cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AGAAAACTTACTTTATATCCT	0.338000													9	53					0	0	0.004482	0	0
CUBNP3	100421634	broad.mit.edu	37	10	45644202	45644202	+	RNA	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:45644202G>A	ENST00000427229.2	+	0	373																											TACTTCTCCTGGCTATGATGG	0.393000													21	13					0	0	0.003954	0	0
CPT1B	1375	broad.mit.edu	37	22	51015406	51015406	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr22:51015406G>A	ENST00000360719.2	-	4	476	c.339C>T	c.(337-339)tcC>tcT	p.S113S	CPT1B_ENST00000312108.7_Silent_p.S113S|CPT1B_ENST00000405237.3_Silent_p.S113S|CPT1B_ENST00000434492.2_5'UTR|CPT1B_ENST00000440709.1_Silent_p.S113S|CPT1B_ENST00000395650.2_Silent_p.S113S|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000457250.1_Silent_p.S113S	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	113					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		AGACGCCCGTGGAGAAGATGG	0.607000											OREG0026685	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	55					0	0	0.003610	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17495594	17495594	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:17495594C>T	ENST00000377602.4	-	2	238	c.164G>A	c.(163-165)cGg>cAg	p.R55Q		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	55					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						CGCCGGGCTCCGGAGCGTCCT	0.716000													4	2					0	0	0.000602	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45568343	45568343	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:45568343C>A	ENST00000256692.5	-	0	342					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GAATGAACTTCAATTTCACAG	0.443000													30	47					1.30897e-18	2.37925e-18	0.001786	1	0
LRP1B	53353	broad.mit.edu	37	2	141108413	141108413	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:141108413T>C	ENST00000389484.3	-	77	12816	c.11845A>G	c.(11845-11847)Aaa>Gaa	p.K3949E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3949					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGATCCTTTTGTAGAAAATT	0.348000										TSP Lung(27;0.18)			9	19					0	0	0.006214	0	0
WDPCP	51057	broad.mit.edu	37	2	63631787	63631787	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:63631787C>A	ENST00000409120.1	-	4	3805	c.255G>T	c.(253-255)ctG>ctT	p.L85L	WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000409562.3_Silent_p.L277L|WDPCP_ENST00000409199.1_Silent_p.L85L|WDPCP_ENST00000272321.7_Silent_p.L277L|WDPCP_ENST00000398544.3_Silent_p.L118L			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	277					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						GGACAGAACTCAGAACCTGTT	0.408000													19	39					3.99206e-14	6.77772e-14	0.007413	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765873	171765873	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:171765873G>A	ENST00000311601.5	-	13	2406	c.2236C>T	c.(2236-2238)Cct>Tct	p.P746S	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	746	Pro-rich.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTTGGAGAGGAACAGGCACG	0.602000													14	45					0	0	0.001855	0	0
GLI2	2736	broad.mit.edu	37	2	121726325	121726325	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:121726325C>A	ENST00000452319.1	+	6	739	c.679C>A	c.(679-681)Ctg>Atg	p.L227M	GLI2_ENST00000361492.4_Missense_Mutation_p.L227M|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000314490.11_5'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	227					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GACGCCCCGCCTGAGCCGCAA	0.642000													22	79					7.33532e-06	9.89788e-06	0.003954	1	0
DUSP7	1849	broad.mit.edu	37	3	52088311	52088311	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:52088311C>A	ENST00000495880.1	-	2	780	c.597G>T	c.(595-597)tcG>tcT	p.S199S	DUSP7_ENST00000296483.6_Silent_p.S148S			Q16829	DUS7_HUMAN	dual specificity phosphatase 7	199	Ser-rich.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGGTGGGTGGCGAGCTGCTCG	0.627000													13	42					1.49906e-05	2.01395e-05	0.002450	1	0
GATA1	2623	broad.mit.edu	37	X	48652212	48652212	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:48652212C>A	ENST00000376670.3	+	6	994	c.883C>A	c.(883-885)Ctg>Atg	p.L295M	GATA1_ENST00000376665.3_Intron	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	295					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						GAACCGGCCACTGACCATGCG	0.567000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								7	17					0.00448238	0.00551815	0.004482	1	0
TRPM4	54795	broad.mit.edu	37	19	49675355	49675355	+	Silent	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:49675355C>G	ENST00000252826.5	+	9	1266	c.1140C>G	c.(1138-1140)gcC>gcG	p.A380A	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000427978.2_Silent_p.A380A	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	380					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TTTTGAAGGCCCTTGTGAAGG	0.502000													28	43					0	0	0.007291	0	0
MFSD7	84179	broad.mit.edu	37	4	678304	678304	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:678304C>A	ENST00000322224.4	-	6	1121	c.808G>T	c.(808-810)Gag>Tag	p.E270*	MFSD7_ENST00000503156.1_Nonsense_Mutation_p.E206*|MFSD7_ENST00000347950.5_Nonsense_Mutation_p.E152*|MFSD7_ENST00000404286.2_Nonsense_Mutation_p.E271*|MFSD7_ENST00000515118.1_Nonsense_Mutation_p.E174*			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	271					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						AGGATCTGCTCCAGGAGGGCT	0.622000											OREG0016025	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	63					9.90819e-18	1.79043e-17	0.003610	1	0
BCORL1	63035	broad.mit.edu	37	X	129155073	129155073	+	Silent	SNP	G	G	A	rs61754128		TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:129155073G>A	ENST00000540052.1	+	4	3599	c.3555G>A	c.(3553-3555)ccG>ccA	p.P1185P	BCORL1_ENST00000359304.2_Silent_p.P1185P|BCORL1_ENST00000303743.5_Silent_p.P1185P|BCORL1_ENST00000218147.7_Silent_p.P1185P	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1185					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						ACCGGAAGCCGACAAAGCCGG	0.627000													16	36					0	0	0.004990	0	0
NCSTN	23385	broad.mit.edu	37	1	160324028	160324028	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:160324028C>G	ENST00000368063.1	+	12	1520	c.1240C>G	c.(1240-1242)Cga>Gga	p.R414G	NCSTN_ENST00000535857.1_Missense_Mutation_p.R296G|NCSTN_ENST00000459963.1_3'UTR|NCSTN_ENST00000368065.4_Missense_Mutation_p.R176G|NCSTN_ENST00000294785.5_Missense_Mutation_p.R434G|NCSTN_ENST00000392212.4_Missense_Mutation_p.R414G			Q92542	NICA_HUMAN	nicastrin	434					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTTCGAGCTCGAAACATCTC	0.522000													17	85					0	0	0.004990	0	0
STAB2	55576	broad.mit.edu	37	12	104054150	104054150	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:104054150C>A	ENST00000388887.2	+	16	1980	c.1776C>A	c.(1774-1776)gtC>gtA	p.V592V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	592	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ACCACATTGTCCCATTTACCC	0.423000													76	171					4.78148e-37	9.98296e-37	0.003610	1	0
ARHGAP10	79658	broad.mit.edu	37	4	148984305	148984305	+	Silent	SNP	C	C	A	rs144731909	byFrequency	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:148984305C>A	ENST00000336498.3	+	21	2273	c.2034C>A	c.(2032-2034)ggC>ggA	p.G678G	ARHGAP10_ENST00000414545.2_Intron	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	678					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TTAGCCCAGGCCAGACCCGAT	0.517000													13	67					7.93312e-07	1.08948e-06	0.002450	1	0
CNTN3	5067	broad.mit.edu	37	3	74474018	74474018	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:74474018G>A	ENST00000263665.6	-	4	459	c.432C>T	c.(430-432)tgC>tgT	p.C144C		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	144	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GTGGGGGGCCGCAGAGCAGCA	0.443000													8	22					0	0	0.004482	0	0
NDRG4	65009	broad.mit.edu	37	16	58537784	58537784	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:58537784C>A	ENST00000394282.4	+	4	667	c.260C>A	c.(259-261)aCc>aAc	p.T87N	NDRG4_ENST00000568640.1_Missense_Mutation_p.T53N|NDRG4_ENST00000394279.2_Missense_Mutation_p.T67N|NDRG4_ENST00000356752.4_Missense_Mutation_p.T65N|NDRG4_ENST00000570248.1_Missense_Mutation_p.T35N|NDRG4_ENST00000258187.5_Missense_Mutation_p.T67N|NDRG4_ENST00000569923.1_5'UTR|NDRG4_ENST00000563799.1_Missense_Mutation_p.T35N|NDRG4_ENST00000566192.1_Missense_Mutation_p.T35N|NDRG4_ENST00000563022.1_3'UTR|NDRG4_ENST00000562999.1_Missense_Mutation_p.T35N	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	35					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						GCCATCCTCACCTACCATGAT	0.637000													18	28					0.000132079	0.00017367	0.008871	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146997300	146997300	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:146997300C>T	ENST00000361727.3	+	9	1932	c.1416C>T	c.(1414-1416)ctC>ctT	p.L472L		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	472	Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTGCTATTCTCACCATCGATG	0.413000										HNSCC(39;0.1)			10	48					0	0	0.008291	0	0
MMAA	166785	broad.mit.edu	37	4	146560343	146560343	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:146560343A>G	ENST00000281317.5	+	2	1262	c.52A>G	c.(52-54)Aga>Gga	p.R18G	MMAA_ENST00000541599.1_5'UTR	NM_172250.2	NP_758454.1	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblA type	18						mitochondrion	GTP binding|nucleoside-triphosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)	17	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGCCTTTTAAGAGCACCTTT	0.438000													22	70					0	0	0.001882	0	0
CACNA2D1	781	broad.mit.edu	37	7	81593561	81593561	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:81593561C>A	ENST00000356860.3	-	33	3027	c.2689G>T	c.(2689-2691)Gca>Tca	p.A897S	CACNA2D1_ENST00000535308.1_Missense_Mutation_p.A109S|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.A909S	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	909						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGTTTTGGTGCAGCACCGGGC	0.423000													33	39					1.58521e-26	3.26552e-26	0.005524	1	0
TEX14	56155	broad.mit.edu	37	17	56700349	56700349	+	Silent	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:56700349A>T	ENST00000389934.3	-	4	393	c.276T>A	c.(274-276)ccT>ccA	p.P92P	TEX14_ENST00000349033.5_Silent_p.P92P|TEX14_ENST00000240361.8_Silent_p.P92P	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	92						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCATGGACAGGGGTGCTCC	0.567000													13	38					0	0	0.001368	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001288	13001288	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:13001288T>G	ENST00000376189.1	-	3	494	c.395A>C	c.(394-396)aAa>aCa	p.K132T	PRAMEF6_ENST00000415464.2_Missense_Mutation_p.K132T|PRAMEF6_ENST00000376192.5_Intron	NM_001010889.2	NP_001010889.1	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	132										NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACTGGTGTTTTGTTCCTCTT	0.493000													44	796					0	0	0.002222	0	0
OR4C13	283092	broad.mit.edu	37	11	49974135	49974135	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:49974135G>T	ENST00000555099.1	+	1	193	c.161G>T	c.(160-162)aGa>aTa	p.R54I		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						CCATCACTGAGATCCCCCATG	0.428000													52	104					3.76997e-23	7.41987e-23	0.003610	1	0
USO1	8615	broad.mit.edu	37	4	76725312	76725312	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr4:76725312A>T	ENST00000538159.1	+	19	2039	c.2039A>T	c.(2038-2040)cAg>cTg	p.Q680L	USO1_ENST00000514213.2_Missense_Mutation_p.Q656L			O60763	USO1_HUMAN	USO1 vesicle transport factor	671					intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GAATTAAGGCAGCAGGTTTCT	0.368000													10	8					0	0	0.006214	0	0
TEX14	56155	broad.mit.edu	37	17	56676480	56676480	+	Silent	SNP	G	G	A	rs114600472	by1000genomes	TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:56676480G>A	ENST00000389934.3	-	14	2343	c.2226C>T	c.(2224-2226)caC>caT	p.H742H	TEX14_ENST00000349033.5_Silent_p.H742H|TEX14_ENST00000240361.8_Silent_p.H748H	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	748						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CATCATTCTCGTGCATTATTG	0.428000													53	134					0	0	0.003610	0	0
FYN	2534	broad.mit.edu	37	6	111983047	111983047	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:111983047C>A	ENST00000354650.3	-	14	2115	c.1509G>T	c.(1507-1509)tgG>tgT	p.W503C	FYN_ENST00000229470.5_Missense_Mutation_p.W451C|FYN_ENST00000368678.4_Missense_Mutation_p.W500C|FYN_ENST00000368682.3_Missense_Mutation_p.W500C|FYN_ENST00000538466.1_Missense_Mutation_p.W500C|FYN_ENST00000368667.2_Missense_Mutation_p.W503C|FYN_ENST00000356013.2_Missense_Mutation_p.W448C|FYN_ENST00000229471.4_Missense_Mutation_p.W448C	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	503	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTCCTTTTTCCAGCAGTGGA	0.567000													59	89					1.80625e-27	3.74585e-27	0.003610	1	0
EGFL6	25975	broad.mit.edu	37	X	13607713	13607713	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:13607713C>A	ENST00000361306.1	+	2	370	c.113C>A	c.(112-114)cCt>cAt	p.P38H	EGFL6_ENST00000380602.3_Missense_Mutation_p.P38H	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	38					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						GCACGTCAGCCTGGGGTCTGT	0.458000													20	46					5.26018e-13	8.73868e-13	0.001882	1	0
OVCH2	341277	broad.mit.edu	37	11	7723352	7723352	+	RNA	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:7723352A>T	ENST00000454689.1	-	0	469				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GGGCCCCACAAAGTGGCCTGA	0.502000													6	7					0	0	0.001984	0	0
KIAA0556	23247	broad.mit.edu	37	16	27789020	27789020	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:27789020C>T	ENST00000261588.4	+	26	4660	c.4641C>T	c.(4639-4641)acC>acT	p.T1547T		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1547										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GTGAGCCCACCGTGCCCTACC	0.642000													8	72					0	0	0.006214	0	0
ITIH6	347365	broad.mit.edu	37	X	54818409	54818409	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:54818409G>T	ENST00000218436.6	-	3	347	c.318C>A	c.(316-318)atC>atA	p.I106I		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	106	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CTTCTTCATAGATTTTCTTTG	0.458000													24	56					3.73148e-12	6.00535e-12	0.007291	1	0
EMX2	2018	broad.mit.edu	37	10	119303110	119303110	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:119303110C>T	ENST00000553456.3	+	1	1156	c.332C>T	c.(331-333)tCg>tTg	p.S111L	EMX2_ENST00000442245.4_Missense_Mutation_p.S111L|EMX2OS_ENST00000551288.1_RNA	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	111						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CTATTCGCCTCGCAGCAGCGG	0.697000													21	70					0	0	0.001882	0	0
MAGI2	9863	broad.mit.edu	37	7	77824308	77824308	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:77824308G>A	ENST00000354212.4	-	12	2405	c.2152C>T	c.(2152-2154)Ccc>Tcc	p.P718S	MAGI2_ENST00000522391.1_Missense_Mutation_p.P718S|MAGI2_ENST00000419488.1_Missense_Mutation_p.P718S	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	718						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGTGGGAAGGGCAGGTTCTGC	0.517000													24	44					0	0	0.002780	0	0
MUC16	94025	broad.mit.edu	37	19	9065219	9065219	+	Silent	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:9065219G>C	ENST00000397910.4	-	3	22430	c.22227C>G	c.(22225-22227)tcC>tcG	p.S7409S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7411	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGGTAATGTGGAAGAAACAG	0.522000													3	31					0	0	0.000248	0	0
EFCAB13	124989	broad.mit.edu	37	17	45473278	45473278	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:45473278C>G	ENST00000331493.2	+	17	2291	c.1880C>G	c.(1879-1881)tCt>tGt	p.S627C	EFCAB13_ENST00000517484.1_Missense_Mutation_p.S531C	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		AATACTCTGTCTAGTTTGAAT	0.353000													4	58					0	0	0.000248	0	0
TAAR8	83551	broad.mit.edu	37	6	132874309	132874309	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:132874309C>T	ENST00000275200.1	+	1	478	c.478C>T	c.(478-480)Ctc>Ttc	p.L160F		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	160						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		GATTCTGCCTCTCACGTACAG	0.493000													108	119					0	0	0.003610	0	0
TBX5	6910	broad.mit.edu	37	12	114793477	114793477	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:114793477G>T	ENST00000310346.4	-	9	2083	c.1417C>A	c.(1417-1419)Cag>Aag	p.Q473K	TBX5_ENST00000349716.5_Missense_Mutation_p.Q423K|TBX5_ENST00000405440.2_Missense_Mutation_p.Q473K	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	473					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AGGCCAGTCTGAGGCCCACAC	0.627000													12	41					1.61879e-10	2.53912e-10	0.001368	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52800415	52800415	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52800415C>T	ENST00000287727.3	+	15	3817	c.3645C>T	c.(3643-3645)taC>taT	p.Y1215Y	ZFYVE9_ENST00000357206.2_Silent_p.Y1156Y|ZFYVE9_ENST00000371591.1_Silent_p.Y1215Y|ZFYVE9_ENST00000469134.1_3'UTR	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	1215					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						CTTCTGGATACCTTGCCAAGT	0.403000													28	55					0	0	0.006320	0	0
CDKN2C	1031	broad.mit.edu	37	1	51436088	51436088	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:51436088G>A	ENST00000262662.1	+	3	2082	c.48G>A	c.(46-48)ggG>ggA	p.G16G	CDKN2C_ENST00000371761.3_Silent_p.G16G|CDKN2C_ENST00000396148.1_Silent_p.G16G			P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	16					cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(11)		central_nervous_system(8)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|thyroid(1)	23				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		CTGCCAGGGGGGACCTAGAGC	0.473000			D		"""glioma, MM"""								7	48					0	0	0.004482	0	0
LCA5	167691	broad.mit.edu	37	6	80223222	80223222	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:80223222G>C	ENST00000392959.1	-	4	1038	c.427C>G	c.(427-429)Cag>Gag	p.Q143E	LCA5_ENST00000467898.2_Missense_Mutation_p.Q143E|LCA5_ENST00000369846.4_Missense_Mutation_p.Q143E	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	143					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GCTTTCTCCTGTCTGTACTGA	0.363000													5	57					0	0	0.000602	0	0
POTEF	728378	broad.mit.edu	37	2	130877604	130877604	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:130877604C>A	ENST00000357462.5	-	1	578	c.485G>T	c.(484-486)aGg>aTg	p.R162M	POTEF_ENST00000409914.2_Missense_Mutation_p.R162M|POTEF_ENST00000360967.5_Missense_Mutation_p.R162M|POTEF_ENST00000361163.4_Missense_Mutation_p.R162M			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	162						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GTCAGTGTCCCTGAGCATGAC	0.587000													30	21					6.84511e-11	1.09028e-10	0.003271	1	0
PRDM2	7799	broad.mit.edu	37	1	14106289	14106289	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:14106289C>G	ENST00000235372.7	+	8	2855	c.1999C>G	c.(1999-2001)Ctt>Gtt	p.L667V	PRDM2_ENST00000343137.4_Missense_Mutation_p.L466V|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.L466V|PRDM2_ENST00000311066.5_Missense_Mutation_p.L667V|PRDM2_ENST00000376048.5_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	667						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTCTTTAAGTCTTCCTCTTAG	0.453000													29	28					0	0	0.007291	0	0
TTC3	7267	broad.mit.edu	37	21	38538740	38538740	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr21:38538740G>T	ENST00000399017.2	+	33	6971	c.4224G>T	c.(4222-4224)gaG>gaT	p.E1408D	TTC3_ENST00000355666.1_Missense_Mutation_p.E1408D|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.E1408D	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1408					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AGATCCTTGAGGGCTCTTTGG	0.438000													37	39					1.22674e-20	2.35443e-20	0.008740	1	0
OR52N1	79473	broad.mit.edu	37	11	5809749	5809749	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:5809749G>T	ENST00000317078.1	-	1	297	c.298C>A	c.(298-300)Ctc>Atc	p.L100I	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATCTGGGCGAGGCAGGCTTTA	0.517000													19	43					3.99206e-14	6.77772e-14	0.007413	1	0
DSP	1832	broad.mit.edu	37	6	7569537	7569537	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:7569537C>A	ENST00000379802.3	+	12	1879	c.1538C>A	c.(1537-1539)cCt>cAt	p.P513H	DSP_ENST00000418664.2_Missense_Mutation_p.P513H	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	513	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTGATCATCCCTCCTCCGAAC	0.577000													34	32					1.36161e-19	2.54993e-19	0.004289	1	0
FAM83B	222584	broad.mit.edu	37	6	54805349	54805349	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:54805349A>G	ENST00000306858.7	+	5	1696	c.1580A>G	c.(1579-1581)gAg>gGg	p.E527G		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	527										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GATAATCCTGAGAATTTGAAG	0.398000													12	36					0	0	0.000978	0	0
ASXL1	171023	broad.mit.edu	37	20	31022609	31022609	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:31022609G>T	ENST00000375687.4	+	13	2518	c.2094G>T	c.(2092-2094)ccG>ccT	p.P698P	ASXL1_ENST00000306058.5_Silent_p.P693P	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	698					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AACTACTGCCGCCTTATCCTC	0.587000			"""F, N, Mis"""		"""MDS, CMML"""								6	17					0.00448238	0.00551815	0.004482	1	0
ERMAP	114625	broad.mit.edu	37	1	43308742	43308742	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:43308742G>T	ENST00000328249.3	+	9	2035	c.997G>T	c.(997-999)Gtc>Ttc	p.V333F	RP11-342M1.2_ENST00000416809.2_RNA|RP11-342M1.4_ENST00000414798.1_RNA|ERMAP_ENST00000372514.3_Missense_Mutation_p.V423F|ERMAP_ENST00000372517.2_Missense_Mutation_p.V423F|RP11-342M1.3_ENST00000444563.1_RNA|RP11-342M1.3_ENST00000425076.1_RNA|ERMAP_ENST00000487556.1_3'UTR			Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein (Scianna blood group)	423	B30.2/SPRY.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGAATCAATTGTCCCCAGGCC	0.478000													43	68					3.54561e-26	7.25558e-26	0.002222	1	0
MAGEB16	139604	broad.mit.edu	37	X	35821063	35821063	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:35821063C>G	ENST00000399989.1	+	2	1029	c.750C>G	c.(748-750)atC>atG	p.I250M	MAGEB16_ENST00000399988.1_Missense_Mutation_p.I250M|MAGEB16_ENST00000399992.1_Missense_Mutation_p.I282M|MAGEB16_ENST00000399985.1_Missense_Mutation_p.I250M|MAGEB16_ENST00000399987.1_Missense_Mutation_p.I250M	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	250	MAGE.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GAATGCTCATCACCAAAGATT	0.502000													21	30					0	0	0.008871	0	0
CD84	8832	broad.mit.edu	37	1	160523270	160523270	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:160523270G>T	ENST00000368054.3	-	4	693	c.658C>A	c.(658-660)Cgt>Agt	p.R220S	CD84_ENST00000311224.4_Missense_Mutation_p.R220S|CD84_ENST00000368051.3_Missense_Mutation_p.R220S|CD84_ENST00000368048.3_Missense_Mutation_p.R220S|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000534968.1_Missense_Mutation_p.R106S	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	220					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGTGAGTACGGAAGCCCATT	0.493000													17	51					3.41278e-10	5.27275e-10	0.004990	1	0
ADCY9	115	broad.mit.edu	37	16	4164490	4164490	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:4164490C>A	ENST00000294016.3	-	2	1492	c.954G>T	c.(952-954)atG>atT	p.M318I		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	318					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCTTCCCGTGCATAATGGATT	0.547000													37	40					5.43694e-19	1.006e-18	0.005524	1	0
OR4X1	390113	broad.mit.edu	37	11	48286115	48286115	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:48286115C>A	ENST00000320048.1	+	1	703	c.703C>A	c.(703-705)Ctc>Atc	p.L235I		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GCACAAGGCCCTCTCCACCTG	0.537000													23	49					1.9806e-07	2.76925e-07	0.002299	1	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139140	90139140	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:90139140C>A	ENST00000492446.1	+	0	63																											TCCTGGGGCTCCTGCTGCTCT	0.512000													46	157					8.13277e-46	1.70954e-45	0.003610	1	0
FAM27L	284123	broad.mit.edu	37	17	21826173	21826173	+	RNA	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr17:21826173C>A	ENST00000426869.3	+	0	356					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		AGCAGGCCCACGTCCAAGAAG	0.522000													26	56					7.38237e-10	1.12928e-09	0.006320	1	0
GGCX	2677	broad.mit.edu	37	2	85777724	85777724	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:85777724G>A	ENST00000233838.3	-	14	2118	c.2038C>T	c.(2038-2040)Cga>Tga	p.R680*	GGCX_ENST00000430215.3_Nonsense_Mutation_p.R623*	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	680					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CGGAAGAATCGCTCATGGAAA	0.483000													47	62					0	0	0.003214	0	0
WT1	7490	broad.mit.edu	37	11	32413517	32413517	+	Splice_Site	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:32413517C>T	ENST00000332351.3	-	9	1717		c.e9+1		WT1_ENST00000530998.1_Splice_Site|WT1_ENST00000448076.3_Intron|WT1_ENST00000379079.2_Intron	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1						adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AGTTTACGCACTTGTTTTACC	0.378000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				30	88					0	0	0.003755	0	0
LRRTM3	347731	broad.mit.edu	37	10	68857466	68857466	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:68857466C>A	ENST00000361320.4	+	3	2236	c.1658C>A	c.(1657-1659)aCg>aAg	p.T553K	CTNNA3_ENST00000373744.4_Intron|LRRTM3_ENST00000485868.1_3'UTR|CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	553						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						CAGGAAGATACGATGGAAACA	0.468000													12	60					2.27111e-07	3.14696e-07	0.001368	1	0
SLC8A3	6547	broad.mit.edu	37	14	70633417	70633417	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:70633417C>A	ENST00000381269.2	-	2	2476	c.1723G>T	c.(1723-1725)Ggt>Tgt	p.G575C	SLC8A3_ENST00000357887.3_Missense_Mutation_p.G575C|SLC8A3_ENST00000528359.1_Missense_Mutation_p.G575C|SLC8A3_ENST00000534137.1_Missense_Mutation_p.G575C|SLC8A3_ENST00000356921.2_Missense_Mutation_p.G575C	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	575	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCACCGCCACCCTTGGCTGTC	0.512000													28	48					4.59853e-10	7.06938e-10	0.005443	1	0
EGFL6	25975	broad.mit.edu	37	X	13624535	13624535	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:13624535C>A	ENST00000361306.1	+	6	815	c.558C>A	c.(556-558)ccC>ccA	p.P186P	EGFL6_ENST00000380602.3_Silent_p.P186P	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	186	EGF-like 4; calcium-binding (Potential).				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						TCATCTGTCCCTACAATCGAA	0.408000													32	67					3.76114e-14	6.45662e-14	0.004289	1	0
LPHN2	23266	broad.mit.edu	37	1	82409007	82409007	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:82409007A>T	ENST00000370728.1	+	8	1397	c.752A>T	c.(751-753)cAt>cTt	p.H251L	LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370717.2_Missense_Mutation_p.H251L|LPHN2_ENST00000370721.1_Missense_Mutation_p.H255L|LPHN2_ENST00000370713.1_Missense_Mutation_p.H251L|LPHN2_ENST00000370723.1_Missense_Mutation_p.H251L|LPHN2_ENST00000370730.1_Missense_Mutation_p.H251L|LPHN2_ENST00000370715.1_Missense_Mutation_p.H251L|LPHN2_ENST00000370725.1_Missense_Mutation_p.H251L|LPHN2_ENST00000370727.1_Missense_Mutation_p.H251L|LPHN2_ENST00000359929.3_Missense_Mutation_p.H251L|LPHN2_ENST00000271029.4_Missense_Mutation_p.H251L|LPHN2_ENST00000335786.5_Missense_Mutation_p.H251L|LPHN2_ENST00000394879.1_Missense_Mutation_p.H251L|LPHN2_ENST00000319517.6_Missense_Mutation_p.H251L			O95490	LPHN2_HUMAN	latrophilin 2	251	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCCAACTACCATGATACCTCA	0.403000													12	46					0	0	0.000978	0	0
ACSBG2	81616	broad.mit.edu	37	19	6187335	6187335	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:6187335C>A	ENST00000588304.1	+	12	1878	c.1432C>A	c.(1432-1434)Cct>Act	p.P478T	ACSBG2_ENST00000252669.5_Missense_Mutation_p.P528T|ACSBG2_ENST00000586696.1_Missense_Mutation_p.P528T|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000591403.1_Missense_Mutation_p.P528T|ACSBG2_ENST00000588485.1_Missense_Mutation_p.P341T			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	528					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCCCCCCATTCCTGTTGAGAC	0.478000													56	25					5.86059e-21	1.13183e-20	0.003610	1	0
CCDC62	84660	broad.mit.edu	37	12	123270367	123270367	+	Splice_Site	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr12:123270367G>T	ENST00000253079.6	+	4	842	c.498_splice	c.e4+1	p.K166_splice	CCDC62_ENST00000537566.1_Intron|CCDC62_ENST00000392441.4_Splice_Site_p.K166_splice|CCDC62_ENST00000392440.2_Intron	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	166						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		TAAAGCTAAAGGTAATCAAAA	0.408000													25	47					7.87624e-14	1.32992e-13	0.002780	1	0
CCKBR	887	broad.mit.edu	37	11	6291107	6291107	+	Silent	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:6291107C>T	ENST00000525462.1	+	2	363	c.360C>T	c.(358-360)ttC>ttT	p.F120F	CCKBR_ENST00000334619.2_Silent_p.F120F|CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000525014.1_Silent_p.F120F			P32239	GASR_HUMAN	cholecystokinin B receptor	115					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TGGGCACATTCATCTTTGGCA	0.587000													8	31					0	0	0.003080	0	0
PROKR2	128674	broad.mit.edu	37	20	5294591	5294591	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:5294591G>T	ENST00000546004.1	-	2	671	c.425C>A	c.(424-426)tCc>tAc	p.S142Y	PROKR2_ENST00000217270.3_Missense_Mutation_p.S142Y			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	142						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GGCATTGGTGGAGACGTAGAG	0.597000										HNSCC(71;0.22)			17	13					1.5739e-10	2.4813e-10	0.004007	1	0
SPATA2	9825	broad.mit.edu	37	20	48522689	48522689	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr20:48522689T>A	ENST00000422556.1	-	3	1379	c.1030A>T	c.(1030-1032)Agg>Tgg	p.R344W	SPATA2_ENST00000289431.5_Missense_Mutation_p.R344W|SPATA2_ENST00000543716.1_Missense_Mutation_p.R207W	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	344					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TAGGTGGCCCTGGGTTCAGAG	0.637000													24	25					0	0	0.002780	0	0
TFAP2D	83741	broad.mit.edu	37	6	50718983	50718983	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:50718983C>A	ENST00000008391.3	+	7	1313	c.1085C>A	c.(1084-1086)tCc>tAc	p.S362Y	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	362	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity	p.S362Y(1)		NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CTGGGATCCTCCAGACCCACT	0.353000													8	22					0.000274275	0.000356097	0.004482	1	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr21:44524456G>A	ENST00000291552.4	-	2	193	c.101C>T	c.(100-102)tCt>tTt	p.S34F	U2AF1_ENST00000486519.1_5'UTR|U2AF1_ENST00000398137.1_5'UTR|U2AF1_ENST00000380276.2_Missense_Mutation_p.S34F|U2AF1_ENST00000459639.1_5'UTR	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	34					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding	p.S34F(45)|p.S34Y(12)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GTGCAACCGAGAGCACCTGTC	0.358000			Mis		"""CLL, MDS"""								3	6					0	0	0.004672	0	0
PGBD4	161779	broad.mit.edu	37	15	34395533	34395533	+	Silent	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:34395533G>A	ENST00000397766.2	+	1	1260	c.801G>A	c.(799-801)ccG>ccA	p.P267P		NM_152595.4	NP_689808.2	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	267										breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|pancreas(1)|prostate(1)	16		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		AGTACCTCCCGACAAAACGAG	0.413000													9	16					0	0	0.004482	0	0
TIAM2	26230	broad.mit.edu	37	6	155465783	155465783	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:155465783G>T	ENST00000461783.3	+	8	2947	c.1674G>T	c.(1672-1674)atG>atT	p.M558I	TIAM2_ENST00000318981.5_Missense_Mutation_p.M558I|TIAM2_ENST00000456144.1_Missense_Mutation_p.M558I|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000360366.4_Missense_Mutation_p.M558I|TIAM2_ENST00000529824.2_Missense_Mutation_p.M558I			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	558	PH 1.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGAATTCCATGGATCAGAGCA	0.488000													29	41					2.12542e-12	3.47489e-12	0.006320	1	0
NFKBIZ	64332	broad.mit.edu	37	3	101574687	101574687	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:101574687A>G	ENST00000326172.5	+	9	1880	c.1765A>G	c.(1765-1767)Aag>Gag	p.K589E	NFKBIZ_ENST00000394054.2_Missense_Mutation_p.K489E|NFKBIZ_ENST00000326151.5_Missense_Mutation_p.K467E	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	589	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						ACTGAAGAATAAGAGTCTGGT	0.448000													13	25					0	0	0.001368	0	0
MROH7	374977	broad.mit.edu	37	1	55144499	55144499	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:55144499C>T	ENST00000414150.2	+	11	2299	c.2021C>T	c.(2020-2022)cCg>cTg	p.P674L	MROH7_ENST00000339553.5_Missense_Mutation_p.P674L|MROH7_ENST00000545244.1_Missense_Mutation_p.P242L|MROH7_ENST00000395690.2_Missense_Mutation_p.P674L|MROH7_ENST00000421030.2_Missense_Mutation_p.P674L|MROH7_ENST00000454855.2_Missense_Mutation_p.P192L|MROH7_ENST00000409996.1_Missense_Mutation_p.P242L					maestro heat-like repeat family member 7																		CCTGTGAGCCCGTGCCAGAAC	0.587000													15	36					0	0	0.004007	0	0
ZNF728	388523	broad.mit.edu	37	19	23159426	23159426	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr19:23159426C>A	ENST00000594710.1	-	4	858	c.713G>T	c.(712-714)aGt>aTt	p.S238I		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		TGAGAACTTACTAAAGGCTTT	0.413000													8	11					5.18039e-06	7.05172e-06	0.003080	1	0
RPGR	6103	broad.mit.edu	37	X	38146127	38146127	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chrX:38146127C>A	ENST00000378505.2	-	15	2301	c.2125G>T	c.(2125-2127)Gag>Tag	p.E709*	RPGR_ENST00000318842.7_Intron|RPGR_ENST00000342811.3_Intron|RPGR_ENST00000339363.3_Intron|RPGR_ENST00000338898.3_Intron|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000309513.3_Intron	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	698	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						tgctcctgctcttccccatcc	0.537000													11	21					0.000673444	0.000852845	0.008291	1	0
SLC24A4	123041	broad.mit.edu	37	14	92909770	92909770	+	Silent	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr14:92909770G>T	ENST00000532405.1	+	7	835	c.609G>T	c.(607-609)gtG>gtT	p.V203V	SLC24A4_ENST00000531433.1_Silent_p.V203V|SLC24A4_ENST00000298877.1_Silent_p.V186V|SLC24A4_ENST00000351924.5_Silent_p.V186V|SLC24A4_ENST00000393265.2_Silent_p.V139V			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	203						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GGTGGGCCGTGTGCCGAGACT	0.657000													29	40					1.88708e-17	3.39017e-17	0.008361	1	0
CSMD3	114788	broad.mit.edu	37	8	114326911	114326911	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr8:114326911G>C	ENST00000297405.5	-	2	534	c.290C>G	c.(289-291)gCa>gGa	p.A97G	CSMD3_ENST00000352409.3_Missense_Mutation_p.A97G|CSMD3_ENST00000455883.2_Missense_Mutation_p.A97G|CSMD3_ENST00000343508.3_Missense_Mutation_p.A57G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	97	CUB 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCGTTCTTCTGCTATTATTAC	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			65	80					0	0	0.003610	0	0
MARK1	4139	broad.mit.edu	37	1	220824025	220824025	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:220824025G>A	ENST00000402574.1	+	14	2131	c.1129G>A	c.(1129-1131)Gat>Aat	p.D377N	MARK1_ENST00000366917.4_Missense_Mutation_p.D512N|MARK1_ENST00000366918.4_Missense_Mutation_p.D490N	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	512					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AAGGACCACAGATCGATACGT	0.383000													53	62					0	0	0.003610	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60998401	60998401	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:60998401G>A	ENST00000373880.4	+	4	796	c.532G>A	c.(532-534)Gga>Aga	p.G178R	PHYHIPL_ENST00000472199.1_3'UTR|PHYHIPL_ENST00000373878.3_Missense_Mutation_p.G152R	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	178										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						AGTGATTGCAGGACGCATGCT	0.308000													20	69					0	0	0.007413	0	0
OR4F6	390648	broad.mit.edu	37	15	102346553	102346553	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr15:102346553T>C	ENST00000328882.4	+	1	652	c.631T>C	c.(631-633)Ttt>Ctt	p.F211L		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTGGCTTCTTTTTTAATTCT	0.363000													40	31					0	0	0.005524	0	0
USP31	57478	broad.mit.edu	37	16	23080722	23080722	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:23080722C>A	ENST00000219689.7	-	16	2703	c.2704G>T	c.(2704-2706)Gca>Tca	p.A902S	USP31_ENST00000567975.1_Missense_Mutation_p.A195S	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	902	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		TCATCTGCTGCCTCCCCAATC	0.522000													12	24					1.08611e-07	1.53245e-07	0.000978	1	0
PIK3CB	5291	broad.mit.edu	37	3	138456718	138456718	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:138456718C>A	ENST00000477593.1	-	5	705	c.632G>T	c.(631-633)aGc>aTc	p.S211I	PIK3CB_ENST00000289153.2_Missense_Mutation_p.S211I			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	211	PI3K-RBD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						CACTTGAAAGCTAAACACGTC	0.348000													6	26					8.12818e-05	0.000107794	0.001984	1	0
ATRNL1	26033	broad.mit.edu	37	10	117228685	117228685	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr10:117228685G>T	ENST00000355044.3	+	24	3626	c.3500G>T	c.(3499-3501)gGa>gTa	p.G1167V	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Missense_Mutation_p.G218V	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1167						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATTTTAGCTGGAACAATATCT	0.219000													7	10					2.0095e-06	2.7475e-06	0.001984	1	0
COL6A3	1293	broad.mit.edu	37	2	238250709	238250709	+	Splice_Site	SNP	C	C	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr2:238250709C>T	ENST00000295550.4	-	37	8216	c.7765_splice	c.e37+1	p.L2588_splice	COL6A3_ENST00000409809.1_Splice_Site_p.L2382_splice|COL6A3_ENST00000347401.3_Splice_Site_p.L2387_splice|COL6A3_ENST00000353578.4_Splice_Site_p.L2382_splice|COL6A3_ENST00000346358.4_Splice_Site_p.L2388_splice|COL6A3_ENST00000472056.1_Splice_Site_p.L1981_splice	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2588	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAGCTTACCCAAGCAAACAT	0.463000													5	21					0	0	0.000602	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576368	33576368	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:33576368G>T	ENST00000504830.1	-	19	4098	c.3763C>A	c.(3763-3765)Cac>Aac	p.H1255N	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.H1170N	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1255	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCTGGCTGGTGGTCTCCTCCC	0.527000										HNSCC(64;0.19)			83	85					9.46827e-25	1.91222e-24	0.003610	1	0
CMTM7	112616	broad.mit.edu	37	3	32495741	32495741	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:32495741G>T	ENST00000334983.5	+	5	759	c.523G>T	c.(523-525)Gtc>Ttc	p.V175F	CMTM7_ENST00000349718.4_Missense_Mutation_p.V142F	NM_138410.2	NP_612419.1	Q96FZ5	CKLF7_HUMAN	CKLF-like MARVEL transmembrane domain containing 7	175					chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(2)	4						AGATGCAGCCGTCTGATGAGG	0.587000													16	41					5.3912e-06	7.3065e-06	0.006122	1	0
CSF1R	1436	broad.mit.edu	37	5	149447883	149447883	+	Silent	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr5:149447883C>A	ENST00000286301.3	-	11	1812	c.1521G>T	c.(1519-1521)acG>acT	p.T507T		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	507					cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCGGGGGATGCGTGTGGGCTC	0.597000													9	29					2.74318e-10	4.28102e-10	0.006214	1	0
ORC1	4998	broad.mit.edu	37	1	52867035	52867035	+	Splice_Site	SNP	A	A	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:52867035A>G	ENST00000371568.3	-	3	440	c.223_splice	c.e3+1	p.D74_splice	ORC1_ENST00000371566.1_Splice_Site_p.D74_splice	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	74	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CAAACTCACCATCTTCGAACA	0.438000													16	107					0	0	0.004007	0	0
TAF1L	138474	broad.mit.edu	37	9	32634632	32634632	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr9:32634632C>A	ENST00000242310.4	-	1	1035	c.946G>T	c.(946-948)Gct>Tct	p.A316S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	316					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGTGGTGGAGCATAGTCATAG	0.473000													33	20					1.08312e-15	1.89087e-15	0.001786	1	0
TP53TG3D	729264	broad.mit.edu	37	16	32264990	32264990	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr16:32264990A>T	ENST00000398664.3	+	1	951	c.316A>T	c.(316-318)Aca>Tca	p.T106S	TP53TG3D_ENST00000354614.3_Missense_Mutation_p.T106S|TP53TG3D_ENST00000569631.1_Intron|RP11-56L13.7_ENST00000562604.1_RNA	NM_001243722.1	NP_001230651.1			TP53 target 3D																		TTGCAGATCAACAAAGGGTCG	0.582000													33	79					0	0	0.003271	0	0
ZNF648	127665	broad.mit.edu	37	1	182026538	182026538	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:182026538G>T	ENST00000339948.3	-	2	815	c.608C>A	c.(607-609)aCg>aAg	p.T203K		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TGTCTCTTGCGTGGGAAGGTC	0.592000													21	18					0.00121646	0.00152181	0.008871	1	0
TMEM79	84283	broad.mit.edu	37	1	156255576	156255576	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr1:156255576delG	ENST00000405535.2	+	2	730	c.559delG	c.(559-561)ggfs	p.G188fs	TMEM79_ENST00000495881.1_3'UTR|TMEM79_ENST00000295694.5_Frame_Shift_Del_p.G188fs|TMEM79_ENST00000357501.2_Intron	NM_032323.2	NP_115699.1	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	188						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|urinary_tract(1)	21	Hepatocellular(266;0.158)					CTGTTCCTGTGGGGGCTGCGG	0.667													36	90	---	---	---	---					
CNTN3	5067	broad.mit.edu	37	3	74411066	74411066	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr3:74411066delC	ENST00000263665.6	-	10	1366	c.1339delG	c.(1339-1341)atfs	p.D447fs		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	447	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACGCTCACATCCCCCTTCTTC	0.473													17	69	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:42196333delT	ENST00000541110.1	-	18	3981	c.3413delA	c.(3412-3414)agfs	p.K1138fs	TRERF1_ENST00000340840.2_Frame_Shift_Del_p.K1047fs|TRERF1_ENST00000372917.4_Frame_Shift_Del_p.K1047fs|TRERF1_ENST00000372922.4_Frame_Shift_Del_p.K1118fs|TRERF1_ENST00000354325.2_Frame_Shift_Del_p.K1035fs			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542													8	2246	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43305681	43305681	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:43305681delC	ENST00000361428.2	-	10	6132	c.6055delG	c.(6055-6057)atfs	p.D2019fs	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2019					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ACAGGCATATCCCCCAGATTC	0.458													38	60	---	---	---	---					
CNR1	1268	broad.mit.edu	37	6	88853971	88853971	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr6:88853971delT	ENST00000537554.1	-	2	4585	c.1023delA	c.(1021-1023)ttfs	p.L341fs	CNR1_ENST00000549890.1_Frame_Shift_Del_p.L341fs|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000369499.2_Frame_Shift_Del_p.L341fs|CNR1_ENST00000535130.1_Frame_Shift_Del_p.L341fs|CNR1_ENST00000468898.1_Frame_Shift_Del_p.L308fs|CNR1_ENST00000428600.2_Frame_Shift_Del_p.L341fs|CNR1_ENST00000549716.1_Frame_Shift_Del_p.L280fs|CNR1_ENST00000369501.2_Frame_Shift_Del_p.L341fs	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	341					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GGGTCTTGGCTAACCTAATGT	0.537													28	79	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91632378	91632378	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr7:91632378delG	ENST00000359028.2	+	9	3408	c.3183delG	c.(3181-3183)atfs	p.M1061fs	AKAP9_ENST00000356239.3_Frame_Shift_Del_p.M1049fs|AKAP9_ENST00000358100.2_Frame_Shift_Del_p.M1061fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1061					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAAAAATAATGGTGGAAGATA	0.338			T	BRAF	papillary thyroid								22	29	---	---	---	---					
RP11-807H22.7	0	broad.mit.edu	37	11	71888667	71888669	+	RNA	DEL	GAC	GAC	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:71888667_71888669delGAC	ENST00000378140.3	-	0	419				RP11-807H22.6_ENST00000539482.1_RNA																							TCAGGTGAGGGACGGAGGAGATG	0.581													6	10	---	---	---	---					
BTG4	54766	broad.mit.edu	37	11	111367899	111367900	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:111367899_111367900insA	ENST00000525791.1	-	4	730_731	c.546_547insT	c.(544-549)tttatcfs	p.I183fs	BTG4_ENST00000356018.2_Intron			Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	183					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		GAATTAGATAGAAAAAAAGTAT	0.317													15	19	---	---	---	---					
TP53AIP1	63970	broad.mit.edu	37	11	128807581	128807582	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr11:128807581_128807582delGT	ENST00000602346.1	-	2	341_342	c.132_133delAC	c.(130-135)acctfs	p.TP44fs	TP53AIP1_ENST00000458238.2_Frame_Shift_Del_p.TP44fs|TP53AIP1_ENST00000530777.1_Frame_Shift_Del_p.TP44fs|TP53AIP1_ENST00000531399.1_Frame_Shift_Del_p.TP44fs	NM_001251964.1	NP_001238893.1	Q9HCN2	TPIP1_HUMAN	tumor protein p53 regulated apoptosis inducing protein 1	44					apoptosis	mitochondrion				large_intestine(1)|lung(1)|skin(1)	3						ACCCAGCCAGGTGTGTGTGTCT	0.624													8	58	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11047643	11047644	+	RNA	INS	-	-	G			TCGA-78-7145-01A-11D-2036-08	TCGA-78-7145-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8e2a385-20ef-48bf-a802-11a6a75f0d06	264c83bc-2e97-4cc6-8a96-d96db0bbf9c3	g.chr21:11047643_11047644insG	ENST00000470054.1	-	0	659									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAACTTATGTTTTGCAACATAA	0.371													17	89	---	---	---	---					
