Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PYGL	5836	broad.mit.edu	37	14	51401905	51401905	+	Splice_Site	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:51401905T>A	ENST00000216392.7	-	3	678		c.e3-2		PYGL_ENST00000544180.2_Splice_Site|PYGL_ENST00000532462.1_Splice_Site	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver						glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CAATCCAAGCTGGTAATGAAA	0.418000													14	17					0	0	0.001855	0	0
DBF4	10926	broad.mit.edu	37	7	87533696	87533696	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:87533696T>C	ENST00000265728.1	+	11	1518	c.1014T>C	c.(1012-1014)ttT>ttC	p.F338F		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	338					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TTTTTGACTTTGTGGAATATG	0.363000													7	23					0	0	0.001984	0	0
OR4C16	219428	broad.mit.edu	37	11	55340262	55340262	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:55340262T>G	ENST00000314634.3	+	1	659	c.659T>G	c.(658-660)tTg>tGg	p.L220W		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L220S(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTCATCTTCTTGCATTCTCTG	0.418000													10	31					0	0	0.008291	0	0
ANK2	287	broad.mit.edu	37	4	114158246	114158246	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:114158246T>A	ENST00000357077.4	+	6	640	c.587T>A	c.(586-588)cTg>cAg	p.L196Q	ANK2_ENST00000264366.6_Missense_Mutation_p.L196Q|ANK2_ENST00000506722.1_Missense_Mutation_p.L175Q|ANK2_ENST00000394537.3_Missense_Mutation_p.L196Q	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	196					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGCCAGCTCTGCATATTGCC	0.517000													80	81					0	0	0.003610	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364605	142364605	+	RNA	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:142364605T>A	ENST00000390397.2	+	0	276																											GAGAGATCTCTGATGGATACA	0.473000													4	53					0	0	0.000248	0	0
HTR2A	3356	broad.mit.edu	37	13	47409077	47409077	+	Silent	SNP	C	C	T	rs143205112		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:47409077C>T	ENST00000378688.4	-	3	1442	c.1311G>A	c.(1309-1311)aaG>aaA	p.K437K	HTR2A_ENST00000543956.1_Silent_p.K353K|HTR2A_ENST00000542664.1_Silent_p.K437K			P28223	5HT2A_HUMAN	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	437					ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TATCTGTTGTCTTGGCATCTT	0.413000													14	84					0	0	0.002450	0	0
WDR19	57728	broad.mit.edu	37	4	39271619	39271619	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:39271619G>A	ENST00000399820.3	+	31	3536	c.3382G>A	c.(3382-3384)Gtt>Att	p.V1128I	WDR19_ENST00000288634.7_Missense_Mutation_p.V968I	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1128					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TGCACACGATGTTCTCTTCAG	0.433000													6	36					0	0	0.001168	0	0
PKD1L2	114780	broad.mit.edu	37	16	81145941	81145941	+	RNA	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:81145941C>A	ENST00000534142.1	-	0	1198				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000533478.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TAGCCAAGGGCGGCATCGGCT	0.532000													23	33					1.55795e-14	2.86227e-14	0.001882	1	0
OR2W3	343171	broad.mit.edu	37	1	248059177	248059177	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:248059177T>A	ENST00000537741.1	+	3	546	c.289T>A	c.(289-291)Tgt>Agt	p.C97S	OR2W3_ENST00000360358.3_Missense_Mutation_p.C97S			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTACATGGGCTGTGCCATCCA	0.572000													30	78					0	0	0.002445	0	0
ACSM3	6296	broad.mit.edu	37	16	20781403	20781403	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:20781403T>C	ENST00000289416.5	+	2	522	c.47T>C	c.(46-48)tTt>tCt	p.F16S	ACSM3_ENST00000440284.2_Missense_Mutation_p.F16S	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	16					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						GCCAAGTGTTTTCAGCGCCTA	0.448000													80	47					0	0	0.003610	0	0
NLRP3	114548	broad.mit.edu	37	1	247611773	247611773	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:247611773T>C	ENST00000366497.2	+	9	3687	c.2907T>C	c.(2905-2907)ccT>ccC	p.P969P	NLRP3_ENST00000336119.3_Silent_p.P1026P|NLRP3_ENST00000391828.3_Silent_p.P1026P|NLRP3_ENST00000366496.2_Silent_p.P969P|NLRP3_ENST00000348069.2_Silent_p.P912P|NLRP3_ENST00000391827.2_Silent_p.P969P	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	1026					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAGAAAAGCCTGAGCTGACCG	0.502000													22	30					0	0	0.002780	0	0
MYL10	93408	broad.mit.edu	37	7	101266322	101266322	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:101266322C>T	ENST00000223167.4	-	4	481	c.304G>A	c.(304-306)Ggc>Agc	p.G102S		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	102	EF-hand 1.					mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						TCGATGAAGCCATCACGGTTC	0.627000													12	18					0	0	0.002450	0	0
IGLON5	402665	broad.mit.edu	37	19	51826947	51826947	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:51826947G>T	ENST00000270642.8	+	3	190	c.190G>T	c.(190-192)Gcc>Tcc	p.A64S		NM_001101372.1	NP_001094842.1	A6NGN9	IGLO5_HUMAN	IgLON family member 5	64	Ig-like C2-type 1.					extracellular region				large_intestine(5)|lung(6)|prostate(1)	12						GACCCGCGTGGCCTGGCTGAA	0.637000													7	27					8.12818e-05	0.000108224	0.001984	1	0
ZSWIM5	57643	broad.mit.edu	37	1	45500130	45500130	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:45500130A>G	ENST00000359600.5	-	11	2508	c.2303T>C	c.(2302-2304)tTa>tCa	p.L768S		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	768							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					TGAGTTTTCTAAAACAGGTAA	0.542000													25	48					0	0	0.005443	0	0
GSDMD	79792	broad.mit.edu	37	8	144642896	144642896	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:144642896G>A	ENST00000526406.1	+	7	1417	c.534G>A	c.(532-534)cgG>cgA	p.R178R	GSDMD_ENST00000533063.1_Silent_p.R226R|GSDMD_ENST00000262580.4_Silent_p.R178R	NM_001166237.1	NP_001159709.1	P57764	GSDMD_HUMAN	gasdermin D	178										breast(1)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	12						CCCACAAGCGGGAGGGCTCGG	0.697000													3	13					0	0	0.004672	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847712	43847712	+	Silent	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:43847712A>T	ENST00000389420.3	-	12	1757	c.1758T>A	c.(1756-1758)ccT>ccA	p.P586P	ADAMTS20_ENST00000553158.1_Silent_p.P586P	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	586	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGACATACTCAGGACGATTAC	0.423000													3	10					0	0	0.004672	0	0
SNRPN	6638	broad.mit.edu	37	15	25221464	25221464	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:25221464G>T	ENST00000444203.2	+	4	1219	c.180G>T	c.(178-180)gcG>gcT	p.A60A	SNRPN_ENST00000400100.1_Silent_p.A56A|SNRPN_ENST00000390687.4_Silent_p.A56A|SNRPN_ENST00000577565.1_Silent_p.A56A|SNRPN_ENST00000346403.6_Silent_p.A56A|SNRPN_ENST00000400098.1_Silent_p.A56A|SNRPN_ENST00000400097.1_Silent_p.A56A|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000554227.2_Silent_p.A60A			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	56					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CAAAGAATGCGAAGCAACCAG	0.423000									Prader-Willi syndrome				11	35					3.07112e-06	4.29413e-06	0.000978	1	0
NLRP14	338323	broad.mit.edu	37	11	7065059	7065059	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:7065059G>A	ENST00000299481.4	+	4	2148	c.1802G>A	c.(1801-1803)tGt>tAt	p.C601Y		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	601					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GCAATGAGATGTTTCCCAAAG	0.423000													20	64					0	0	0.002299	0	0
SLIT2	9353	broad.mit.edu	37	4	20490581	20490581	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:20490581C>G	ENST00000504154.1	+	8	1003	c.751C>G	c.(751-753)Caa>Gaa	p.Q251E	SLIT2_ENST00000273739.5_Missense_Mutation_p.Q251E|SLIT2_ENST00000503837.1_Missense_Mutation_p.Q251E|SLIT2_ENST00000503823.1_Missense_Mutation_p.Q251E	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	251	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGCCGAGGTTCAAAAACGAGA	0.507000													18	92					0	0	0.006122	0	0
PCNX	22990	broad.mit.edu	37	14	71555084	71555084	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:71555084T>G	ENST00000304743.2	+	29	5821	c.5375T>G	c.(5374-5376)cTc>cGc	p.L1792R	PCNX_ENST00000439984.3_Missense_Mutation_p.L1681R|PCNX_ENST00000238570.5_Missense_Mutation_p.L1720R	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1792						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CTAGTGACTCTCTGTTATGGA	0.393000													45	29					0	0	0.003610	0	0
ABCC11	85320	broad.mit.edu	37	16	48249177	48249177	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:48249177C>A	ENST00000394747.1	-	7	1379	c.1030G>T	c.(1030-1032)Gaa>Taa	p.E344*	ABCC11_ENST00000537808.1_Nonsense_Mutation_p.E344*|ABCC11_ENST00000394748.1_Nonsense_Mutation_p.E344*|ABCC11_ENST00000353782.5_Nonsense_Mutation_p.E344*|ABCC11_ENST00000356608.2_Nonsense_Mutation_p.E344*	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	344	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTGAGAACTTCACTGGTCACA	0.448000													6	62					0.00116845	0.00146908	0.001168	1	0
GRM7	2917	broad.mit.edu	37	3	6903419	6903419	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:6903419C>T	ENST00000486284.1	+	1	618	c.344C>T	c.(343-345)gCg>gTg	p.A115V	GRM7_ENST00000403881.1_Missense_Mutation_p.A115V|GRM7_ENST00000402647.2_Missense_Mutation_p.A115V|GRM7_ENST00000389336.4_Missense_Mutation_p.A115V|GRM7_ENST00000357716.4_Missense_Mutation_p.A115V	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	115					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GACACTTACGCGCTCGAACAG	0.607000													4	30					0	0	0.000248	0	0
RPAP1	26015	broad.mit.edu	37	15	41828728	41828728	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:41828728G>C	ENST00000304330.4	-	3	417	c.301C>G	c.(301-303)Cac>Gac	p.H101D	RPAP1_ENST00000561603.1_Missense_Mutation_p.H101D	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	101						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCAGTGATGTGCTGATCATGC	0.547000													11	60					0	0	0.001368	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954779	72954779	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:72954779T>A	ENST00000421285.3	+	11	1034	c.1034T>A	c.(1033-1035)aTg>aAg	p.M345K		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	345										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						CAGGAGGAGATGCTCCGAGAG	0.557000													95	145					0	0	0.003610	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086478	46086478	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr21:46086478C>T	ENST00000360770.3	-	1	366	c.326G>A	c.(325-327)aGc>aAc	p.S109N	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	109	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						AGGCCTGCAGCTCACAGGCAC	0.642000													11	63					0	0	0.001855	0	0
ASTN1	460	broad.mit.edu	37	1	176863850	176863850	+	Missense_Mutation	SNP	G	G	T	rs147140947	byFrequency	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:176863850G>T	ENST00000367654.2	-	17	2825	c.2812C>A	c.(2812-2814)Cgc>Agc	p.R938S	ASTN1_ENST00000361833.2_Missense_Mutation_p.R930S|ASTN1_ENST00000367657.3_Missense_Mutation_p.R930S|ASTN1_ENST00000424564.2_Missense_Mutation_p.R930S			O14525	ASTN1_HUMAN	astrotactin 1	938					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CACTCCATGCGGACTCCAGCC	0.607000													26	96					2.41591e-17	4.7016e-17	0.004656	1	0
CCDC39	339829	broad.mit.edu	37	3	180334315	180334315	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:180334315A>G	ENST00000442201.2	-	18	2694	c.2575T>C	c.(2575-2577)Tac>Cac	p.Y859H	CCDC39_ENST00000273654.4_3'UTR|TTC14_ENST00000382584.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	859					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGTTGAAAGTATGTTTGAAGG	0.279000													3	9					0	0	0.004672	0	0
ZNF460	10794	broad.mit.edu	37	19	57803456	57803456	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:57803456G>C	ENST00000360338.3	+	3	1869	c.1547G>C	c.(1546-1548)aGc>aCc	p.S516T	ZNF460_ENST00000537645.1_Missense_Mutation_p.S475T	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTTGTGAGAGCACAGATCTC	0.527000													13	65					0	0	0.001368	0	0
USP26	83844	broad.mit.edu	37	X	132161952	132161952	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:132161952G>T	ENST00000511190.1	-	6	766	c.297C>A	c.(295-297)gaC>gaA	p.D99E	USP26_ENST00000406273.1_Missense_Mutation_p.D99E|USP26_ENST00000370832.1_Missense_Mutation_p.D99E	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	99					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					GATGAACTCTGTCCAAGAATA	0.388000													7	30					0.00198382	0.00245517	0.001984	1	0
CYP26B1	56603	broad.mit.edu	37	2	72362006	72362006	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:72362006T>A	ENST00000001146.2	-	4	948	c.745A>T	c.(745-747)Aag>Tag	p.K249*	CYP26B1_ENST00000546307.1_Nonsense_Mutation_p.K174*|CYP26B1_ENST00000412253.1_Nonsense_Mutation_p.K58*	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	249					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						CGGATGGCCTTCTCCAGCCCC	0.612000													10	55					0	0	0.001855	0	0
PF4	5196	broad.mit.edu	37	4	74847209	74847209	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:74847209G>T	ENST00000296029.3	-	2	313	c.143C>A	c.(142-144)tCc>tAc	p.S48Y		NM_002619.3	NP_002610.1	P02776	PLF4_HUMAN	platelet factor 4	48					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding	p.S48F(1)		kidney(1)|lung(1)	2	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	ACGGACCTGGGAGGTGGTCTT	0.602000													10	20					0.00621372	0.00751352	0.006214	1	0
SNTG1	54212	broad.mit.edu	37	8	51363114	51363114	+	Splice_Site	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:51363114A>T	ENST00000522124.1	+	7	938		c.e7-1		SNTG1_ENST00000276467.5_Splice_Site|SNTG1_ENST00000518864.1_Splice_Site|SNTG1_ENST00000517473.1_Splice_Site	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TTTCATTCACAGCGGAACTTT	0.274000													45	39					0	0	0.003610	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590379	140590379	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:140590379G>T	ENST00000239450.2	+	1	2089	c.1900G>T	c.(1900-1902)Gac>Tac	p.D634Y	PCDHB12_ENST00000541609.1_Missense_Mutation_p.D297Y	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		634	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCGAGCGCGACGCGGCCAA	0.697000													12	81					3.41278e-10	5.63644e-10	0.004990	1	0
SLC12A9	56996	broad.mit.edu	37	7	100452363	100452363	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:100452363G>T	ENST00000354161.3	+	3	428	c.303G>T	c.(301-303)ggG>ggT	p.G101G	SLC12A9_ENST00000428758.1_Silent_p.G101G|SLC12A9_ENST00000540482.1_Silent_p.G101G|SLC12A9_ENST00000415287.1_Intron|SLC12A9_ENST00000275729.3_Intron	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	101						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCGTGCAGGGGGGCGGAGCCT	0.612000													24	41					6.12954e-19	1.22076e-18	0.004656	1	0
NTM	50863	broad.mit.edu	37	11	132177606	132177606	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:132177606G>T	ENST00000374786.1	+	4	1029	c.550G>T	c.(550-552)Gaa>Taa	p.E184*	NTM_ENST00000427481.2_Nonsense_Mutation_p.E175*|NTM_ENST00000374784.1_Nonsense_Mutation_p.E184*|NTM_ENST00000539799.1_Nonsense_Mutation_p.E184*|NTM_ENST00000374791.3_Nonsense_Mutation_p.E184*|NTM_ENST00000425719.2_Nonsense_Mutation_p.E184*|NTM_ENST00000474900.1_3'UTR	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	184	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.E184K(2)|p.E184*(2)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GAGTGAAGACGAATACTTGGA	0.493000													10	51					7.48243e-07	1.08461e-06	0.006214	1	0
NLRP4	147945	broad.mit.edu	37	19	56390295	56390295	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:56390295C>A	ENST00000301295.6	+	9	3254	c.2832C>A	c.(2830-2832)gcC>gcA	p.A944A	NLRP4_ENST00000346986.5_Silent_p.A888A|NLRP4_ENST00000587891.1_Silent_p.A869A	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	944							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGTGAGGCCCTGAGACACC	0.592000													15	25					6.31663e-08	9.75271e-08	0.003163	1	0
TM9SF3	56889	broad.mit.edu	37	10	98311156	98311156	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:98311156C>A	ENST00000371142.4	-	7	1021	c.805G>T	c.(805-807)Gga>Tga	p.G269*	TM9SF3_ENST00000490192.1_5'UTR	NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	269						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TATTCATCTCCTAGGTCTCTA	0.328000													16	36					1.15088e-07	1.73731e-07	0.004007	1	0
CEP192	55125	broad.mit.edu	37	18	13056511	13056511	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:13056511G>T	ENST00000506447.1	+	19	4002	c.3922G>T	c.(3922-3924)Gtg>Ttg	p.V1308L	CEP192_ENST00000430049.2_Missense_Mutation_p.V833L|CEP192_ENST00000325971.8_Missense_Mutation_p.V712L	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	903										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCAGAACTCTGTGGCTGTGGG	0.512000													22	33					1.10513e-12	1.96192e-12	0.002299	1	0
OR6T1	219874	broad.mit.edu	37	11	123813658	123813658	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:123813658C>A	ENST00000321252.2	-	1	922	c.888G>T	c.(886-888)aaG>aaT	p.K296N		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CTTGCTGCACCTTGTCATTGC	0.512000													6	147					1.26484e-09	2.05321e-09	0.003080	1	0
P2RY6	5031	broad.mit.edu	37	11	73008546	73008546	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:73008546G>A	ENST00000393590.2	+	2	1282	c.983G>A	c.(982-984)cGc>cAc	p.R328H	P2RY6_ENST00000349767.2_Missense_Mutation_p.R328H|P2RY6_ENST00000542092.1_Missense_Mutation_p.R328H|P2RY6_ENST00000393591.1_Missense_Mutation_p.R328H|P2RY6_ENST00000540124.1_Missense_Mutation_p.R328H|P2RY6_ENST00000540342.1_Missense_Mutation_p.R328H|P2RY6_ENST00000538328.1_Missense_Mutation_p.R328H|P2RY6_ENST00000393592.2_Missense_Mutation_p.R328H	NM_001277207.1|NM_001277208.1	NP_001264136.1|NP_001264137.1	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 6	328					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)	14						AGGCAGGGTCGCTGAGTCCTC	0.577000													10	29					0	0	0.008291	0	0
ZNF488	118738	broad.mit.edu	37	10	48371133	48371133	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:48371133C>A	ENST00000395702.2	+	2	828	c.601C>A	c.(601-603)Ctc>Atc	p.L201I	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Missense_Mutation_p.L94I			Q96MN9	ZN488_HUMAN	zinc finger protein 488	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CACTACAGACCTCGCTTGTTG	0.532000													20	44					0.00229938	0.00283829	0.002299	1	0
FLNA	2316	broad.mit.edu	37	X	153593758	153593758	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:153593758C>A	ENST00000422373.1	-	10	1774	c.1526G>T	c.(1525-1527)gGc>gTc	p.G509V	FLNA_ENST00000360319.4_Missense_Mutation_p.G509V|FLNA_ENST00000369850.3_Missense_Mutation_p.G509V|FLNA_ENST00000344736.4_Missense_Mutation_p.G509V	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	509					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACTGCCAGCGCCCTTTGTGTA	0.672000													19	76					6.94344e-10	1.13882e-09	0.006122	1	0
SLIT2	9353	broad.mit.edu	37	4	20591325	20591325	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:20591325C>T	ENST00000504154.1	+	30	3399	c.3147C>T	c.(3145-3147)caC>caT	p.H1049H	SLIT2_ENST00000273739.5_Silent_p.H1062H|SLIT2_ENST00000503837.1_Silent_p.H1045H|SLIT2_ENST00000503823.1_Silent_p.H1041H	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1049	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CCTGCCAGCACGATTCAAAGT	0.483000													7	37					0	0	0.001984	0	0
SULT2A1	6822	broad.mit.edu	37	19	48374763	48374763	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:48374763C>A	ENST00000222002.3	-	6	946	c.807G>T	c.(805-807)ttG>ttT	p.L269F		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	269					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		TCTCTTGGAACAATTTATCAA	0.443000													21	51					6.44725e-10	1.06111e-09	0.002299	1	0
FER1L6	654463	broad.mit.edu	37	8	125115475	125115475	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:125115475G>C	ENST00000522917.1	+	39	5420	c.5214G>C	c.(5212-5214)gaG>gaC	p.E1738D	FER1L6_ENST00000399018.1_Missense_Mutation_p.E1738D|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1738						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATGCAAGTGAGGAGACCAAGA	0.473000													133	110					0	0	0.003610	0	0
GPC6	10082	broad.mit.edu	37	13	94679996	94679996	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:94679996C>A	ENST00000377047.4	+	4	1340	c.725C>A	c.(724-726)cCa>cAa	p.P242Q		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	242						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				AGCCCAACCCCAGGGTGTATC	0.453000													15	108					1.35283e-19	2.74035e-19	0.004007	1	0
GUCY2F	2986	broad.mit.edu	37	X	108696812	108696812	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:108696812G>T	ENST00000218006.2	-	4	1600	c.1309C>A	c.(1309-1311)Cct>Act	p.P437T		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	437					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						AAGTGAATAGGGGTCCCTCCG	0.488000													11	47					1.49906e-05	2.02437e-05	0.002450	1	0
SST	6750	broad.mit.edu	37	3	187387016	187387016	+	Missense_Mutation	SNP	G	G	A	rs149673471		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:187387016G>A	ENST00000287641.3	-	2	295	c.188C>T	c.(187-189)aCg>aTg	p.T63M		NM_001048.3	NP_001039.1	P61278	SMS_HUMAN	somatostatin	63					digestion|G-protein coupled receptor protein signaling pathway|induction of apoptosis by hormones|negative regulation of cell proliferation|response to nutrient|synaptic transmission	extracellular space	hormone activity			kidney(1)|large_intestine(1)|lung(6)|pancreas(1)	9	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.00444)	Bromocriptine(DB01200)|Cysteamine(DB00847)	ATCATTCTCCGTCTGGTTGGG	0.517000													30	200					0	0	0.002445	0	0
MYCBP2	23077	broad.mit.edu	37	13	77900726	77900726	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:77900726C>A	ENST00000407578.2	-	1	451	c.185G>T	c.(184-186)gGt>gTt	p.G62V	MYCBP2_ENST00000357337.6_Missense_Mutation_p.G24V|MYCBP2_ENST00000544440.2_Missense_Mutation_p.G24V|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGGTAGTGACCCCGGGAGTC	0.726000													4	13					2.56e-06	3.59006e-06	0.000248	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118364984	118364984	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:118364984G>A	ENST00000528052.1	+	12	1330	c.1259G>A	c.(1258-1260)tGg>tAg	p.W420*	PNLIPRP1_ENST00000534537.1_Nonsense_Mutation_p.W420*|PNLIPRP1_ENST00000358834.4_Nonsense_Mutation_p.W420*			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	420	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		AAGTTTCTTTGGAATAACAAT	0.428000													5	49					0	0	0.001168	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67560590	67560590	+	RNA	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:67560590C>T	ENST00000528089.1	-	0	1160																											AAGTTTTATCCGCTTTCCCAT	0.413000													3	29					0	0	0.001984	0	0
MYT1L	23040	broad.mit.edu	37	2	1914045	1914045	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:1914045G>C	ENST00000399161.2	-	13	2531	c.1784C>G	c.(1783-1785)tCc>tGc	p.S595C	MYT1L_ENST00000428368.2_Missense_Mutation_p.S593C	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	595					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCTGGACTTGGACACGTCGCA	0.612000													11	14					0	0	0.008291	0	0
ITIH5	80760	broad.mit.edu	37	10	7679399	7679399	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:7679399G>T	ENST00000256861.6	-	5	522	c.444C>A	c.(442-444)ccC>ccA	p.P148P	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.P148P|ITIH5_ENST00000397146.2_Silent_p.P148P|ITIH5_ENST00000446830.2_5'UTR	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	148	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TGTCCTTGCTGGGAATCACTG	0.547000													10	52					1.33987e-11	2.30945e-11	0.008291	1	0
MRPS18B	28973	broad.mit.edu	37	6	30593483	30593483	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:30593483G>T	ENST00000259873.4	+	7	843	c.686G>T	c.(685-687)gGc>gTc	p.G229V	MRPS18B_ENST00000472229.1_3'UTR|MRPS18B_ENST00000506373.2_3'UTR	NM_014046.3	NP_054765.1	Q9Y676	RT18B_HUMAN	mitochondrial ribosomal protein S18B	229					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(2)	13						GAAGAGAGTGGCCCCCCACCT	0.597000													9	121					7.48243e-07	1.08461e-06	0.006214	1	0
REG1A	5967	broad.mit.edu	37	2	79350037	79350037	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:79350037G>T	ENST00000233735.1	+	5	495	c.392G>T	c.(391-393)aGt>aTt	p.S131I		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	131	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCCCCAAGCAGTGTTAATCCT	0.577000													36	84					5.04308e-16	9.52358e-16	0.006230	1	0
CCND2	894	broad.mit.edu	37	12	4383338	4383338	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:4383338C>T	ENST00000261254.3	+	1	401	c.132C>T	c.(130-132)ttC>ttT	p.F44F	RP11-264F23.4_ENST00000537370.1_RNA|RP11-264F23.3_ENST00000539135.1_RNA	NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	44	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GCTCCTACTTCAAGTGCGTGC	0.652000			T	IGL@	"""NHL,CLL"""								29	56					0	0	0.007291	0	0
ZNF536	9745	broad.mit.edu	37	19	30934662	30934662	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:30934662G>T	ENST00000355537.3	+	2	340	c.193G>T	c.(193-195)Gag>Tag	p.E65*		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CGCATCCCTGGAGGAGAAGGC	0.677000													20	34					5.26018e-13	9.44441e-13	0.001882	1	0
TRPA1	8989	broad.mit.edu	37	8	72984028	72984028	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:72984028C>A	ENST00000262209.4	-	2	393	c.186G>T	c.(184-186)atG>atT	p.M62I		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	62						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AGAAGGTGTCCATATCGTCAC	0.348000													40	36					9.8876e-21	2.02888e-20	0.004878	1	0
KIAA1467	57613	broad.mit.edu	37	12	13208723	13208723	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:13208723G>T	ENST00000197268.8	+	2	396	c.276G>T	c.(274-276)caG>caT	p.Q92H		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	92						integral to membrane				NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		GCCTGGAACAGAAGGCGGCCT	0.577000													28	66					1.75199e-13	3.16962e-13	0.007291	1	0
CALB2	794	broad.mit.edu	37	16	71423651	71423651	+	Splice_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:71423651G>T	ENST00000302628.4	+	11	776		c.e11-1		CALB2_ENST00000349553.5_Splice_Site	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2								calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GTATTTCCTAGGAAATGAATA	0.517000													78	163					4.81439e-37	1.03728e-36	0.003610	1	0
CYP8B1	1582	broad.mit.edu	37	3	42917134	42917134	+	Missense_Mutation	SNP	G	G	T	rs149860457		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:42917134G>T	ENST00000316161.4	-	1	499	c.175C>A	c.(175-177)Cgc>Agc	p.R59S	KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.R59S|ACKR2_ENST00000471537.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	59					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GTCCTCATGCGCTTCAGAAAT	0.572000													16	27					1.67942e-08	2.64466e-08	0.006122	1	0
OR10J5	127385	broad.mit.edu	37	1	159505512	159505512	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:159505512C>T	ENST00000334857.2	-	1	330	c.286G>A	c.(286-288)Ggc>Agc	p.G96S		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					GTAGCACAGCCTGCCAAGGAG	0.463000													19	59					0	0	0.008871	0	0
CRYGC	1420	broad.mit.edu	37	2	208993087	208993087	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:208993087C>T	ENST00000282141.3	-	3	402	c.365G>A	c.(364-366)cGt>cAt	p.R122H		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	122	Beta/gamma crystallin 'Greek key' 3.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GTGGAGGGAACGGATCTCGCT	0.632000													4	44					0	0	0.000248	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498113	32498113	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:32498113C>T	ENST00000266088.4	+	13	1804	c.1554C>T	c.(1552-1554)ccC>ccT	p.P518P	SLC5A1_ENST00000543737.1_Silent_p.P391P	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	518					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						GCAACTGTCCCACGATTATCT	0.488000													4	54					0	0	0.000248	0	0
ALPI	248	broad.mit.edu	37	2	233322984	233322984	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:233322984C>T	ENST00000295463.3	+	9	1126	c.1049C>T	c.(1048-1050)gCg>gTg	p.A350V		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	350					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding	p.A350V(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CTCACTGAGGCGGTCATGTTC	0.627000													14	38					0	0	0.002450	0	0
TSKS	60385	broad.mit.edu	37	19	50245190	50245190	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:50245190G>T	ENST00000246801.3	-	9	1531	c.1449C>A	c.(1447-1449)ggC>ggA	p.G483G	TSKS_ENST00000358830.3_Silent_p.G283G	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	483							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CAGGAGTCAGGCCCCTCTGCT	0.592000													17	40					1.56452e-12	2.74661e-12	0.007413	1	0
MALAT1	378938	broad.mit.edu	37	11	65265461	65265461	+	RNA	SNP	A	A	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:65265461A>C	ENST00000534336.1	+	0	229					NR_002819.2																						TATTTAGATAAAACCACTCAA	0.493000													7	111					0	0	0.001984	0	0
UBR5	51366	broad.mit.edu	37	8	103309166	103309166	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:103309166C>A	ENST00000520539.1	-	28	4226	c.3620G>T	c.(3619-3621)tGt>tTt	p.C1207F	UBR5_ENST00000521922.1_Missense_Mutation_p.C1201F|UBR5_ENST00000220959.4_Missense_Mutation_p.C1207F	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1207					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTCCGTACAACAACACAGTGA	0.313000													23	16					1.7881e-09	2.8927e-09	0.008361	1	0
TEP1	7011	broad.mit.edu	37	14	20859156	20859156	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:20859156C>A	ENST00000262715.5	-	14	2237	c.2197G>T	c.(2197-2199)Gtg>Ttg	p.V733L	TEP1_ENST00000556935.1_Missense_Mutation_p.V625L	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	733					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GCCTTAAGCACTGCAGTCTTC	0.537000													13	75					1.52009e-12	2.67853e-12	0.003163	1	0
OR13C9	286362	broad.mit.edu	37	9	107379838	107379838	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr9:107379838G>T	ENST00000259362.1	-	1	647	c.648C>A	c.(646-648)atC>atA	p.I216I		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						ATGAGTAAGAGATAACTATCA	0.453000													6	31					5.9392e-07	8.68883e-07	0.001168	1	0
OR4D6	219983	broad.mit.edu	37	11	59224911	59224911	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:59224911G>A	ENST00000300127.2	+	1	501	c.478G>A	c.(478-480)Gta>Ata	p.V160I		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						AATCATCCAGGTAATTCTGAT	0.527000													43	63					0	0	0.002222	0	0
PKHD1	5314	broad.mit.edu	37	6	51935228	51935228	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:51935228C>A	ENST00000371117.3	-	10	958	c.683G>T	c.(682-684)aGc>aTc	p.S228I	PKHD1_ENST00000340994.4_Missense_Mutation_p.S228I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	228	IPT/TIG 2.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TACTGAGAAGCTAACATTCTG	0.388000													12	15					4.3838e-07	6.43319e-07	0.001855	1	0
SLITRK1	114798	broad.mit.edu	37	13	84454234	84454234	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:84454234A>T	ENST00000377084.2	-	1	2294	c.1409T>A	c.(1408-1410)aTg>aAg	p.M470K		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	470						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CAGTTTGGGCATGGCATTGAA	0.557000													5	44					0	0	0.000602	0	0
UGT8	7368	broad.mit.edu	37	4	115585282	115585282	+	Silent	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:115585282A>G	ENST00000310836.6	+	3	1476	c.954A>G	c.(952-954)aaA>aaG	p.K318K	UGT8_ENST00000394511.3_Silent_p.K318K	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	318					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGCCTCAAAAAGTGATTTGGA	0.418000													7	31					0	0	0.003080	0	0
LAS1L	81887	broad.mit.edu	37	X	64744855	64744855	+	Silent	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:64744855T>A	ENST00000374811.3	-	8	1072	c.1032A>T	c.(1030-1032)atA>atT	p.I344I	LAS1L_ENST00000374807.5_Silent_p.I344I|LAS1L_ENST00000312391.8_3'UTR|LAS1L_ENST00000374804.5_Silent_p.I302I	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	344						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						CTTCATATTCTATCTGCAAAG	0.547000													6	21					0	0	0.001984	0	0
HEATR6	63897	broad.mit.edu	37	17	58144875	58144875	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:58144875G>A	ENST00000184956.6	-	8	1174	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F	HEATR6_ENST00000585976.1_Silent_p.F386F	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	386	Poly-Ser.						binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TGGAAGAACTGAAGGATGAGG	0.463000													21	48					0	0	0.002780	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22931922	22931922	+	RNA	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:22931922A>T	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA																							TTATATTTGCAGGAAGTCAGC	0.388000													6	11					0	0	0.001168	0	0
SYT10	341359	broad.mit.edu	37	12	33579232	33579232	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:33579232T>G	ENST00000228567.3	-	2	646	c.350A>C	c.(349-351)aAg>aCg	p.K117T	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	117						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTCATTTTCCTTAATTTCTTT	0.408000													13	87					0	0	0.001855	0	0
MYH7	4625	broad.mit.edu	37	14	23887558	23887558	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:23887558G>T	ENST00000355349.3	-	30	4192	c.4030C>A	c.(4030-4032)Cgg>Agg	p.R1344R		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1344					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TACTGCTCCCGCAGCAGGTCG	0.662000													8	56					5.18039e-06	7.09684e-06	0.003080	1	0
ZNRF4	148066	broad.mit.edu	37	19	5455572	5455572	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:5455572C>T	ENST00000222033.4	+	1	147	c.70C>T	c.(70-72)Ctg>Ttg	p.L24L		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	24						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTCACTGCCTCTGAGCCACGC	0.662000													13	34					0	0	0.001368	0	0
MUC17	140453	broad.mit.edu	37	7	100679543	100679543	+	Missense_Mutation	SNP	G	G	A	rs150842387		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:100679543G>A	ENST00000306151.4	+	3	4910	c.4846G>A	c.(4846-4848)Gct>Act	p.A1616T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1616	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.A1616T(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ATCTACAACCGCTGAAGGTAG	0.502000													14	254					0	0	0.002450	0	0
ELF4	2000	broad.mit.edu	37	X	129200733	129200733	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:129200733G>T	ENST00000308167.5	-	9	2334	c.1955C>A	c.(1954-1956)cCt>cAt	p.P652H	ELF4_ENST00000335997.7_Missense_Mutation_p.P652H	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	652					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GAGGGAAGTAGGGTTGAATGG	0.547000			T	ERG	AML								28	171					5.77227e-19	1.15445e-18	0.008361	1	0
IRAK4	51135	broad.mit.edu	37	12	44161952	44161952	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:44161952G>T	ENST00000448290.2	+	2	109	c.38G>T	c.(37-39)tGc>tTc	p.C13F	IRAK4_ENST00000551736.1_Missense_Mutation_p.C13F|IRAK4_ENST00000431837.1_5'UTR|IRAK4_ENST00000440781.2_Intron	NM_016123.3	NP_057207.2	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	13					innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity					all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TATGTGCGCTGCCTCAATGTT	0.343000													4	16					0.00024832	0.000324253	0.000248	1	0
BAGE2	85319	broad.mit.edu	37	21	11098863	11098863	+	RNA	SNP	A	A	G	rs75318310	by1000genomes	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr21:11098863A>G	ENST00000470054.1	-	0	62									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccagcctccaactcccccttc	0.627000													5	27					0	0	0.001168	0	0
NRK	203447	broad.mit.edu	37	X	105153581	105153581	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:105153581G>C	ENST00000428173.2	+	13	2254	c.1951G>C	c.(1951-1953)Gca>Cca	p.A651P	NRK_ENST00000243300.9_Missense_Mutation_p.A650P			Q7Z2Y5	NRK_HUMAN	Nik related kinase	650							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CTTGCTTCGGGCACCAAACTC	0.483000										HNSCC(51;0.14)			3	9					0	0	0.004672	0	0
AKR1C1	1645	broad.mit.edu	37	10	5014794	5014794	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:5014794G>T	ENST00000380872.4	+	7	891	c.699G>T	c.(697-699)ccG>ccT	p.P233P	AKR1C1_ENST00000434459.2_Silent_p.P233P|AKR1C1_ENST00000477661.1_3'UTR	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						CGAACTCCCCGGTGCTCTTGG	0.592000													22	100					1.39806e-14	2.58859e-14	0.008361	1	0
PRKCG	5582	broad.mit.edu	37	19	54407997	54407997	+	Splice_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:54407997G>T	ENST00000263431.3	+	16	2046		c.e16+1		PRKCG_ENST00000542049.1_Intron|PRKCG_ENST00000540413.1_Splice_Site	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma						activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CTGCAAGGGGGTGAGAGCCCC	0.562000													4	6					0.000602214	0.000769406	0.000602	1	0
MYT1L	23040	broad.mit.edu	37	2	1914044	1914044	+	Silent	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:1914044G>C	ENST00000399161.2	-	13	2532	c.1785C>G	c.(1783-1785)tcC>tcG	p.S595S	MYT1L_ENST00000428368.2_Silent_p.S593S	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	595					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGCTGGACTTGGACACGTCGC	0.617000													11	14					0	0	0.008291	0	0
CALB2	794	broad.mit.edu	37	16	71423652	71423652	+	Splice_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:71423652G>T	ENST00000302628.4	+	11	777	c.699_splice	c.e11-1	p.E234_splice	CALB2_ENST00000349553.5_3'UTR	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	234							calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				TATTTCCTAGGAAATGAATAT	0.522000													78	161					4.81439e-37	1.03728e-36	0.003610	1	0
DDX26B	203522	broad.mit.edu	37	X	134680705	134680705	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:134680705G>T	ENST00000370752.4	+	5	842	c.508G>T	c.(508-510)Gcc>Tcc	p.A170S	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	170	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGTTATTTGCCCTGGTGTT	0.468000													21	81					4.96729e-08	7.69443e-08	0.008871	1	0
NUP98	4928	broad.mit.edu	37	11	3740728	3740728	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:3740728C>A	ENST00000324932.7	-	18	2733	c.2313G>T	c.(2311-2313)ttG>ttT	p.L771F	NUP98_ENST00000359171.4_Missense_Mutation_p.L771F|NUP98_ENST00000355260.3_Missense_Mutation_p.L771F|NUP98_ENST00000397004.4_Missense_Mutation_p.L771F|NUP98_ENST00000397007.4_Missense_Mutation_p.L788F	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	788	Peptidase S59.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CAATATCATCCAAATTTAGAT	0.333000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								20	31					5.03518e-11	8.40379e-11	0.007413	1	0
OR2L13	284521	broad.mit.edu	37	1	248263215	248263215	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:248263215G>T	ENST00000366478.2	+	3	875	c.538G>T	c.(538-540)Gtc>Ttc	p.V180F	OR2L13_ENST00000358120.2_Missense_Mutation_p.V180F	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTTCTGCGATGTCCCAGCCAT	0.458000													58	125					7.92265e-33	1.69159e-32	0.003610	1	0
IGKV3D-15	28875	broad.mit.edu	37	2	90154111	90154111	+	RNA	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:90154111C>G	ENST00000417279.2	+	0	247																											CTCCCAGGCTCCTCATCTATG	0.597000													16	27					0	0	0.005443	0	0
SMAD2	4087	broad.mit.edu	37	18	45394791	45394791	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:45394791G>A	ENST00000402690.2	-	5	952	c.558C>T	c.(556-558)atC>atT	p.I186I	SMAD2_ENST00000586040.1_Silent_p.I156I|SMAD2_ENST00000356825.4_Silent_p.I156I|SMAD2_ENST00000587353.1_5'UTR|SMAD2_ENST00000262160.6_Silent_p.I186I|SMAD2_ENST00000591214.1_Silent_p.I156I	NM_001003652.3	NP_001003652.1	Q15796	SMAD2_HUMAN	SMAD family member 2	186					anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(21)|liver(1)|lung(8)|prostate(2)|urinary_tract(1)	43						GTTCTGTTAGGATCTCGGTGT	0.443000													14	18					0	0	0.003163	0	0
FLG2	388698	broad.mit.edu	37	1	152327652	152327652	+	Silent	SNP	G	G	A	rs12737224		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:152327652G>A	ENST00000388718.5	-	3	2682	c.2610C>T	c.(2608-2610)ggC>ggT	p.G870G	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	870	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGTCCAAAGCCAGATGTCT	0.502000													69	435					0	0	0.003610	0	0
EYS	346007	broad.mit.edu	37	6	66112430	66112430	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:66112430C>G	ENST00000503581.1	-	7	1662	c.1125G>C	c.(1123-1125)gaG>gaC	p.E375D	EYS_ENST00000370621.3_Missense_Mutation_p.E375D|EYS_ENST00000393380.2_Missense_Mutation_p.E375D|EYS_ENST00000370618.3_Missense_Mutation_p.E375D|EYS_ENST00000370616.2_Missense_Mutation_p.E375D|EYS_ENST00000342421.5_Missense_Mutation_p.E375D	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	375	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding	p.E375D(2)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						AAGGAAATGACTCACATGATG	0.284000													11	20					0	0	0.000978	0	0
AEBP1	165	broad.mit.edu	37	7	44146278	44146278	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:44146278G>T	ENST00000223357.3	+	2	692	c.387G>T	c.(385-387)aaG>aaT	p.K129N		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	129	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						AGGCCACCAAGAAGCCCAAGG	0.602000													15	23					1.3612e-06	1.94928e-06	0.003163	1	0
HIST3H2A	92815	broad.mit.edu	37	1	228645213	228645213	+	Silent	SNP	G	G	C	rs142593528		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:228645213G>C	ENST00000366695.2	-	1	347	c.306C>G	c.(304-306)acC>acG	p.T102T		NM_033445.2	NP_254280.1	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a	102					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|lung(3)|ovary(1)	5		Prostate(94;0.183)				CCTGCGCGATGGTCACGCGGC	0.677000													24	74					0	0	0.002780	0	0
GDF10	2662	broad.mit.edu	37	10	48428987	48428987	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:48428987T>A	ENST00000224605.2	-	2	1164	c.899A>T	c.(898-900)gAc>gTc	p.D300V		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	300					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CAGCTCGTTGTCCTGGAGGGG	0.741000													6	9					0	0	0.001984	0	0
ACAN	176	broad.mit.edu	37	15	89400503	89400503	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:89400503G>C	ENST00000439576.2	+	12	5061	c.4687G>C	c.(4687-4689)Ggg>Cgg	p.G1563R	ACAN_ENST00000559004.1_Missense_Mutation_p.G1563R|ACAN_ENST00000561243.1_Missense_Mutation_p.G1563R|ACAN_ENST00000352105.7_Missense_Mutation_p.G1563R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1563					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TTCTGAAGTAGGGACTGACCT	0.512000													41	43					0	0	0.005524	0	0
ZNF682	91120	broad.mit.edu	37	19	20117752	20117752	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:20117752C>A	ENST00000397165.2	-	4	719	c.559G>T	c.(559-561)Ggc>Tgc	p.G187C	ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000597972.1_Missense_Mutation_p.G193C|ZNF682_ENST00000595736.1_Missense_Mutation_p.G111C|ZNF682_ENST00000397162.1_Missense_Mutation_p.G155C|ZNF682_ENST00000358523.5_Missense_Mutation_p.G155C	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TAAGAAAGGCCTGAGTGAGAT	0.323000													6	17					0.00198382	0.00245517	0.001984	1	0
GPM6A	2823	broad.mit.edu	37	4	176594958	176594958	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:176594958C>A	ENST00000280187.7	-	4	305	c.260G>T	c.(259-261)gGc>gTc	p.G87V	GPM6A_ENST00000506894.1_Missense_Mutation_p.G76V|GPM6A_ENST00000515090.1_Missense_Mutation_p.G80V|GPM6A_ENST00000393658.2_Missense_Mutation_p.G87V	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	87						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		AGCTGCGATGCCGTAGATCAC	0.398000													6	14					0.00116845	0.00146908	0.001168	1	0
CDCA7	83879	broad.mit.edu	37	2	174231031	174231031	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:174231031C>T	ENST00000306721.3	+	8	1159	c.1056C>T	c.(1054-1056)tgC>tgT	p.C352C	CDCA7_ENST00000347703.3_Silent_p.C273C|CDCA7_ENST00000392567.2_Intron|CDCA7_ENST00000410019.3_Silent_p.C231C|CDCA7_ENST00000410101.3_Silent_p.C308C	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	273	Mediates transcriptional activity.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			GTCATCAATGCCGTCAGAAGA	0.433000													20	51					0	0	0.001523	0	0
HEATR2	54919	broad.mit.edu	37	7	780463	780463	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:780463G>T	ENST00000297440.6	+	3	808	c.788G>T	c.(787-789)cGg>cTg	p.R263L	HEATR2_ENST00000313147.5_Missense_Mutation_p.R263L|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	263							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CAGGTCCGGCGGGCGGTGGCC	0.637000													55	163					6.52717e-41	1.41921e-40	0.003610	1	0
CDH12	1010	broad.mit.edu	37	5	21842393	21842393	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:21842393C>A	ENST00000382254.1	-	8	1777	c.691G>T	c.(691-693)Gaa>Taa	p.E231*	CDH12_ENST00000504376.2_Nonsense_Mutation_p.E231*|CDH12_ENST00000522262.1_Nonsense_Mutation_p.E191*|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	231	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TGATATTGTTCTTTGACTTCT	0.383000										HNSCC(59;0.17)			27	40					2.65835e-16	5.10144e-16	0.007291	1	0
DMD	1756	broad.mit.edu	37	X	32536160	32536160	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:32536160C>A	ENST00000357033.4	-	18	2463	c.2257G>T	c.(2257-2259)Gaa>Taa	p.E753*	DMD_ENST00000288447.4_Nonsense_Mutation_p.E745*|DMD_ENST00000378677.2_Nonsense_Mutation_p.E749*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	753					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.E749K(2)|p.E748K(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AAGTTGCCTTCCTTCCGAAAG	0.383000													6	25					0.00116845	0.00146908	0.001168	1	0
AUTS2	26053	broad.mit.edu	37	7	69583191	69583191	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:69583191G>A	ENST00000342771.4	+	3	917	c.596G>A	c.(595-597)cGg>cAg	p.R199Q	AUTS2_ENST00000406775.2_Missense_Mutation_p.R199Q|AUTS2_ENST00000403018.2_Missense_Mutation_p.R199Q	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	199										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGCTTCCACCGGAGCAGCTCT	0.428000													3	30					0	0	0.000248	0	0
TMX3	54495	broad.mit.edu	37	18	66344377	66344377	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:66344377C>T	ENST00000299608.2	-	16	1474	c.1158G>A	c.(1156-1158)ctG>ctA	p.L386L		NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	386					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TGATGACACCCAGTGGCAGGC	0.413000													32	56					0	0	0.001786	0	0
ENTPD1	953	broad.mit.edu	37	10	97626107	97626107	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:97626107C>A	ENST00000371203.5	+	9	1673	c.1086C>A	c.(1084-1086)caC>caA	p.H362Q	ENTPD1_ENST00000543964.1_Missense_Mutation_p.H392Q|RP11-429G19.3_ENST00000433113.1_RNA|RP11-248J23.7_ENST00000491114.1_Intron|ENTPD1_ENST00000453258.2_Missense_Mutation_p.H507Q|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000371205.4_Missense_Mutation_p.H500Q|ENTPD1_ENST00000539125.1_Missense_Mutation_p.H362Q|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1_ENST00000371207.3_Missense_Mutation_p.H512Q	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	500					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		TTATCTTTCACAAGCCTTCAT	0.453000													19	37					0.00188189	0.0023536	0.001882	1	0
RPRD2	23248	broad.mit.edu	37	1	150444633	150444633	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:150444633C>G	ENST00000401000.4	+	10	3196	c.3131C>G	c.(3130-3132)tCc>tGc	p.S1044C	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.S1070C			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1070							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GTCTCCTCCTCCTGCTTAGAC	0.532000													5	87					0	0	0.000602	0	0
LCE2D	353141	broad.mit.edu	37	1	152636910	152636910	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:152636910G>A	ENST00000368784.1	+	2	384	c.329G>A	c.(328-330)tGc>tAc	p.C110Y		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	110	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGGGCTGCTGCTGACCTGGG	0.587000													39	56					0	0	0.006999	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2307147	2307147	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:2307147G>A	ENST00000290974.2	-	8	1259	c.920C>T	c.(919-921)gCg>gTg	p.A307V	ZFYVE28_ENST00000511071.1_Missense_Mutation_p.A277V|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.A237V|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	307					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GAGGGCAGGCGCCAGGGCAGC	0.657000													13	33					0	0	0.002450	0	0
STARD8	9754	broad.mit.edu	37	X	67939098	67939098	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:67939098C>A	ENST00000252336.6	+	6	1879	c.1507C>A	c.(1507-1509)Cat>Aat	p.H503N	STARD8_ENST00000374599.3_Missense_Mutation_p.H583N|STARD8_ENST00000374597.3_Missense_Mutation_p.H503N	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	503					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						CCAGAACTCCCATCGTCCCAG	0.587000													16	31					5.03518e-11	8.40379e-11	0.007413	1	0
SYNE1	23345	broad.mit.edu	37	6	152469466	152469466	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:152469466T>C	ENST00000367255.5	-	137	25291	c.24690A>G	c.(24688-24690)gaA>gaG	p.E8230E	SYNE1_ENST00000448038.1_Silent_p.E8159E|SYNE1_ENST00000539504.1_Silent_p.E385E|SYNE1_ENST00000423061.1_Silent_p.E8159E|SYNE1_ENST00000356820.4_Silent_p.E2754E|SYNE1_ENST00000265368.4_Silent_p.E8230E|SYNE1_ENST00000341594.5_Silent_p.E7842E|SYNE1_ENST00000354674.4_Silent_p.E385E|SYNE1_ENST00000347037.5_5'UTR	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8230					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCAGAGTCTTCCAGCTCCA	0.582000										HNSCC(10;0.0054)			13	20					0	0	0.001855	0	0
ATRX	546	broad.mit.edu	37	X	76938620	76938620	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:76938620T>C	ENST00000373344.5	-	9	2342	c.2128A>G	c.(2128-2130)Aat>Gat	p.N710D	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.N672D	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	710					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	GGCTTAGGATTATCTATAGCA	0.353000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						9	242					0	0	0.006214	0	0
ZNF568	374900	broad.mit.edu	37	19	37441573	37441573	+	Silent	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:37441573A>T	ENST00000415168.1	+	5	1702	c.1326A>T	c.(1324-1326)gtA>gtT	p.V442V	ZNF568_ENST00000455427.2_Intron|ZNF568_ENST00000427117.1_Intron|ZNF568_ENST00000333987.7_Silent_p.V506V	NM_001204837.1	NP_001191766.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATGTACAGTATGTGGAAAAG	0.383000													15	47					0	0	0.004007	0	0
DMBX1	127343	broad.mit.edu	37	1	46976691	46976691	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:46976691G>T	ENST00000371956.4	+	3	448	c.433G>T	c.(433-435)Gag>Tag	p.E145*	DMBX1_ENST00000360032.3_Nonsense_Mutation_p.E140*	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	145	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					GAAGGAGGCTGAGGGCTCCCA	0.647000													19	29					2.89027e-11	4.91035e-11	0.002299	1	0
LAMB1	3912	broad.mit.edu	37	7	107638920	107638920	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:107638920G>T	ENST00000393561.1	-	2	487	c.303C>A	c.(301-303)ttC>ttA	p.F101L	LAMB1_ENST00000222399.6_Missense_Mutation_p.F77L|LAMB1_ENST00000393560.1_Missense_Mutation_p.F77L			P07942	LAMB1_HUMAN	laminin, beta 1	77	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGCATATGAAGCATTTTT	0.363000													8	37					1.58986e-06	2.25627e-06	0.008291	1	0
EPHA6	285220	broad.mit.edu	37	3	97167415	97167415	+	Translation_Start_Site	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:97167415C>A	ENST00000442602.2	+	0	16				EPHA6_ENST00000389672.5_Missense_Mutation_p.H579N|EPHA6_ENST00000514100.1_De_novo_Start_InFrame|EPHA6_ENST00000502694.1_De_novo_Start_InFrame			Q9UF33	EPHA6_HUMAN	EPH receptor A6							integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CCCCCAGGAACATGAGCAGCT	0.423000													15	57					0.00244969	0.00301599	0.002450	1	0
KLHL1	57626	broad.mit.edu	37	13	70681438	70681438	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:70681438C>T	ENST00000377844.4	-	1	1153	c.394G>A	c.(394-396)Ggc>Agc	p.G132S	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	132					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AAGTCCATGCCTGGCACCACC	0.582000													45	59					0	0	0.003214	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183212	39183212	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39183212A>T	ENST00000361883.5	-	1	242	c.196T>A	c.(196-198)Tgt>Agt	p.C66S		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	66	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament				central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CTGGTCTCACAGCAGCTTGGC	0.622000													18	52					0	0	0.007413	0	0
KCNH6	81033	broad.mit.edu	37	17	61615428	61615428	+	Missense_Mutation	SNP	C	C	A	rs34770814		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:61615428C>A	ENST00000583023.1	+	7	1515	c.1504C>A	c.(1504-1506)Ctg>Atg	p.L502M	KCNH6_ENST00000581784.1_Missense_Mutation_p.L449M|KCNH6_ENST00000456941.2_Missense_Mutation_p.L449M|KCNH6_ENST00000314672.5_Missense_Mutation_p.L502M	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	502					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GCCCCCAGCCCTGATGTACGC	0.662000													10	18					7.48243e-07	1.08461e-06	0.006214	1	0
CHL1	10752	broad.mit.edu	37	3	424181	424181	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:424181A>T	ENST00000256509.2	+	18	2645	c.2003A>T	c.(2002-2004)aAc>aTc	p.N668I	CHL1_ENST00000397491.2_Missense_Mutation_p.N652I|CHL1-AS1_ENST00000417612.1_RNA	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	652	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTTGAAGGAAACAAAGAAGAG	0.363000													15	47					0	0	0.004007	0	0
SLC22A25	387601	broad.mit.edu	37	11	62997100	62997100	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:62997100G>T	ENST00000306494.6	-	1	24	c.25C>A	c.(25-27)Caa>Aaa	p.Q9K	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	9					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CCTCCAACTTGATCTAGGAGG	0.438000													19	25					5.03518e-11	8.40379e-11	0.007413	1	0
CYP26B1	56603	broad.mit.edu	37	2	72360350	72360350	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:72360350G>T	ENST00000001146.2	-	5	1151	c.948C>A	c.(946-948)ccC>ccA	p.P316P	CYP26B1_ENST00000546307.1_Silent_p.P241P|CYP26B1_ENST00000412253.1_Silent_p.P125P	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	316					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						CCAGCACAGTGGGGTGCTTCA	0.657000													7	26					0.00198382	0.00245517	0.001984	1	0
ASPHD1	253982	broad.mit.edu	37	16	29912884	29912884	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:29912884G>T	ENST00000308748.5	+	1	844	c.592G>T	c.(592-594)Gcc>Tcc	p.A198S	ASPHD1_ENST00000483405.1_5'UTR	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	198					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						CCTGCCTTCAGCCCCCTTTGT	0.667000													62	66					1.7104e-27	3.61932e-27	0.003610	1	0
CD5	921	broad.mit.edu	37	11	60889151	60889151	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:60889151C>A	ENST00000347785.3	+	6	1040	c.874C>A	c.(874-876)Cgc>Agc	p.R292S		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	292	SRCR 3.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CGTGGAGGTGCGCCAGGGGGC	0.657000													12	36					1.08611e-07	1.65005e-07	0.000978	1	0
MLLT4	4301	broad.mit.edu	37	6	168276054	168276054	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:168276054G>T	ENST00000366806.2	+	5	760	c.618G>T	c.(616-618)atG>atT	p.M206I	MLLT4_ENST00000392112.1_Missense_Mutation_p.M205I|MLLT4_ENST00000351017.4_Missense_Mutation_p.M206I|MLLT4_ENST00000447894.2_Missense_Mutation_p.M206I|MLLT4_ENST00000392108.3_Missense_Mutation_p.M206I|MLLT4_ENST00000344191.4_Missense_Mutation_p.M206I|MLLT4_ENST00000400822.3_Missense_Mutation_p.M205I			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	206					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		ACAAAGACATGCCGGAAACCA	0.373000			T	MLL	AL								44	123					1.47857e-17	2.89605e-17	0.003610	1	0
HSP90AA1	3320	broad.mit.edu	37	14	102549360	102549360	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:102549360T>C	ENST00000441629.2	-	7	1351	c.1229A>G	c.(1228-1230)tAc>tGc	p.Y410C	HSP90AA1_ENST00000334701.7_Intron|HSP90AA1_ENST00000216281.8_Intron			P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	0					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GGAAATGCTGTATTCACATAC	0.333000													4	48					0	0	0.000248	0	0
OR52A1	23538	broad.mit.edu	37	11	5173339	5173339	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:5173339G>C	ENST00000380367.1	-	2	678	c.261C>G	c.(259-261)ttC>ttG	p.F87L	OR52A1_ENST00000328942.1_Missense_Mutation_p.F87L			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	87					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTAAACCAGAATATTCCAA	0.453000													4	14					0	0	0.000248	0	0
SEZ6	124925	broad.mit.edu	37	17	27285150	27285150	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:27285150C>T	ENST00000317338.12	-	11	2545	c.2117G>A	c.(2116-2118)cGc>cAc	p.R706H	SEZ6_ENST00000335960.6_Intron|SEZ6_ENST00000442608.3_Missense_Mutation_p.R706H|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000360295.9_Missense_Mutation_p.R706H			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	706						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			TGTGTCATTGCGGGGCACCTC	0.617000													14	42					0	0	0.003163	0	0
SOGA2	23255	broad.mit.edu	37	18	8784761	8784761	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:8784761A>T	ENST00000359865.3	+	6	1793	c.1651A>T	c.(1651-1653)Agc>Tgc	p.S551C	SOGA2_ENST00000517570.1_Missense_Mutation_p.S551C|SOGA2_ENST00000306329.11_Missense_Mutation_p.S911C|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Missense_Mutation_p.S551C	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	902																	AGAGTCCTCTAGCTTCCTCTC	0.607000													15	57					0	0	0.006122	0	0
FCGBP	8857	broad.mit.edu	37	19	40420076	40420076	+	Missense_Mutation	SNP	G	G	T	rs145294097		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:40420076G>T	ENST00000221347.6	-	6	2925	c.2918C>A	c.(2917-2919)aCg>aAg	p.T973K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	973	VWFD 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCAAAGTCCGTGCGCACGAC	0.587000													10	35					0.000442599	0.000571641	0.006214	1	0
YLPM1	56252	broad.mit.edu	37	14	75279466	75279466	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:75279466G>T	ENST00000325680.7	+	11	5607	c.5483G>T	c.(5482-5484)cGg>cTg	p.R1828L	YLPM1_ENST00000552421.1_Missense_Mutation_p.R1122L|YLPM1_ENST00000238571.3_Missense_Mutation_p.R1633L	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1633					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCACCGGGCCGGGAGAGCAGA	0.473000													8	8					0.000157383	0.000206647	0.003080	1	0
NEK10	152110	broad.mit.edu	37	3	27332782	27332782	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:27332782C>A	ENST00000429845.2	-	19	1938	c.1576G>T	c.(1576-1578)Gga>Tga	p.G526*	NEK10_ENST00000341435.5_Nonsense_Mutation_p.G526*|NEK10_ENST00000357467.2_5'UTR			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	526	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCTCCACTTCCAAGATGATCC	0.403000													17	20					2.94398e-08	4.59029e-08	0.007413	1	0
ZNF594	84622	broad.mit.edu	37	17	5085550	5085550	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:5085550C>A	ENST00000399604.4	-	1	2142	c.2002G>T	c.(2002-2004)Gct>Tct	p.A668S	ZNF594_ENST00000575779.1_Missense_Mutation_p.A668S			Q96JF6	ZN594_HUMAN	zinc finger protein 594	668					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TGGTGTGTAGCAAGGTGTGAC	0.468000													24	44					2.89027e-11	4.91035e-11	0.002299	1	0
TNF	7124	broad.mit.edu	37	6	31545256	31545256	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:31545256C>A	ENST00000449264.2	+	4	819	c.644C>A	c.(643-645)cCc>cAc	p.P215H		NM_000594.3	NP_000585.2	P01375	TNFA_HUMAN	tumor necrosis factor	215					activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding	p.P215L(1)|p.P215>?(1)		large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(3)	8		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	ATCAATCGGCCCGACTATCTC	0.602000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				16	28					1.45105e-14	2.67626e-14	0.006122	1	0
GPR141	353345	broad.mit.edu	37	7	37780251	37780251	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:37780251C>A	ENST00000447769.1	+	4	545	c.256C>A	c.(256-258)Ccc>Acc	p.P86T	GPR141_ENST00000334425.1_Missense_Mutation_p.P86T|EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GTTTGGGCTGCCCTTCTGCAA	0.483000													19	37					3.32936e-07	4.90098e-07	0.006122	1	0
TRPM1	4308	broad.mit.edu	37	15	31339443	31339443	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:31339443C>A	ENST00000542188.1	-	14	1999	c.1686G>T	c.(1684-1686)ccG>ccT	p.P562P	TRPM1_ENST00000256552.6_Silent_p.P545P|TRPM1_ENST00000397795.2_Silent_p.P523P	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	523					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGTAATCAGGCGGAAGGTTGC	0.547000													8	39					5.18039e-06	7.09684e-06	0.003080	1	0
FRMPD1	22844	broad.mit.edu	37	9	37746517	37746517	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr9:37746517C>G	ENST00000539465.1	+	16	5081	c.4488C>G	c.(4486-4488)caC>caG	p.H1496Q	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.H1496Q			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1496						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CCTTCCAGCACCTGGTCCAGC	0.637000													12	32					0	0	0.001368	0	0
OR2T1	26696	broad.mit.edu	37	1	248569881	248569881	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:248569881G>A	ENST00000366474.1	+	1	586	c.586G>A	c.(586-588)Gca>Aca	p.A196T		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGATTATAGCAGGTTCCTG	0.542000													19	62					0	0	0.007413	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148747747	148747747	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:148747747G>T	ENST00000514349.1	+	5	1324	c.745G>T	c.(745-747)Ggc>Tgc	p.G249C	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.G339C			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	339					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGGTCCACGGCTACCTCAA	0.552000											OREG0016912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	125					1.22674e-20	2.50636e-20	0.008740	1	0
TENM3	55714	broad.mit.edu	37	4	183713425	183713425	+	Splice_Site	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:183713425A>G	ENST00000511685.1	+	26	5724		c.e26-1		TENM3_ENST00000406950.2_Splice_Site					teneurin transmembrane protein 3																		CTCTCTTTACAGTCCATGGTT	0.478000													12	29					0	0	0.000978	0	0
VAV3	10451	broad.mit.edu	37	1	108507383	108507383	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:108507383G>C	ENST00000370056.4	-	1	383	c.109C>G	c.(109-111)Ctc>Gtc	p.L37V	VAV3_ENST00000527011.1_Missense_Mutation_p.L37V|VAV3_ENST00000371846.4_5'UTR|VAV3-AS1_ENST00000438318.1_RNA	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	37	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CCATCGCGGAGGGTCTGCGCA	0.622000													10	35					0	0	0.008291	0	0
IKBKAP	8518	broad.mit.edu	37	9	111659270	111659270	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr9:111659270T>C	ENST00000374647.5	-	24	2857	c.2550A>G	c.(2548-2550)gaA>gaG	p.E850E	IKBKAP_ENST00000537196.1_Silent_p.E501E	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	850					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CAATTTCCAGTTCTGGGGTTG	0.443000													17	34					0	0	0.008871	0	0
INHBC	3626	broad.mit.edu	37	12	57843451	57843451	+	Silent	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:57843451A>T	ENST00000309668.2	+	2	832	c.705A>T	c.(703-705)cgA>cgT	p.R235R	INHBC_ENST00000550133.1_Intron	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	235					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						AGATTCACCGACGAGGCATCG	0.582000													11	24					0	0	0.000978	0	0
GIPC1	10755	broad.mit.edu	37	19	14591225	14591225	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:14591225C>A	ENST00000393033.4	-	6	816	c.547G>T	c.(547-549)Ggg>Tgg	p.G183W	GIPC1_ENST00000586027.1_Missense_Mutation_p.G183W|GIPC1_ENST00000345425.2_Missense_Mutation_p.G183W|GIPC1_ENST00000591349.1_Missense_Mutation_p.G86W|GIPC1_ENST00000393029.3_Missense_Mutation_p.G86W|GIPC1_ENST00000393028.1_Missense_Mutation_p.G86W	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	183	PDZ.				endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						AGGCTCTGCCCGTTAATGGCC	0.657000											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	70					2.23348e-06	3.16021e-06	0.004007	1	0
UBB	7314	broad.mit.edu	37	17	16285497	16285497	+	Silent	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:16285497A>G	ENST00000302182.3	+	2	668	c.276A>G	c.(274-276)gaA>gaG	p.E92E	UBB_ENST00000535788.1_Intron|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395839.1_Silent_p.E92E|UBB_ENST00000578649.1_Intron|UBB_ENST00000395837.1_Silent_p.E92E	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	92	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding	p.E92E(2)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TCACCCTGGAAGTGGAGCCCA	0.557000													5	97					0	0	0.000602	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118385455	118385455	+	RNA	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:118385455A>T	ENST00000537242.1	+	0	230				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		AAATTAAACCAGCTAATCACT	0.438000													20	22					0	0	0.001523	0	0
ACADM	34	broad.mit.edu	37	1	76205735	76205735	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:76205735G>T	ENST00000370841.4	+	7	976	c.539G>T	c.(538-540)gGa>gTa	p.G180V	ACADM_ENST00000370834.5_Missense_Mutation_p.G213V|ACADM_ENST00000541113.1_Missense_Mutation_p.G144V|ACADM_ENST00000543667.1_5'UTR|ACADM_ENST00000420607.2_Missense_Mutation_p.G184V	NM_000016.4|NM_001127328.1	NP_000007.1|NP_001120800.1	P11310	ACADM_HUMAN	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	180					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	18						GAAAAGAAAGGAGATGAGTAT	0.328000													4	13					0.00024832	0.000324253	0.000248	1	0
LRRC18	474354	broad.mit.edu	37	10	50121487	50121487	+	Silent	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:50121487G>C	ENST00000374160.3	-	1	790	c.714C>G	c.(712-714)ccC>ccG	p.P238P	LRRC18_ENST00000298124.3_Silent_p.P238P|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	238						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						AGATCAGATTGGGAAAGATGG	0.527000													51	97					0	0	0.003610	0	0
ALOXE3	59344	broad.mit.edu	37	17	8018264	8018264	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:8018264C>A	ENST00000380149.1	-	4	1044	c.1014G>T	c.(1012-1014)caG>caT	p.Q338H	ALOXE3_ENST00000448843.2_Missense_Mutation_p.Q182H|ALOXE3_ENST00000318227.3_Missense_Mutation_p.Q314H			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	182	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						ACCTGTCACCCTGGTCTACAC	0.522000													65	141					3.83939e-23	8.05252e-23	0.003610	1	0
PTPRK	5796	broad.mit.edu	37	6	128403661	128403661	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:128403661C>A	ENST00000368227.3	-	10	2064	c.1698G>T	c.(1696-1698)acG>acT	p.T566T	RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000368207.3_Silent_p.T566T|PTPRK_ENST00000368210.3_Silent_p.T566T|PTPRK_ENST00000368226.4_Silent_p.T566T|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Silent_p.T566T|PTPRK_ENST00000532331.1_Silent_p.T566T|PTPRK_ENST00000368215.3_Silent_p.T566T			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	566	Fibronectin type-III 3.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AAAACTGGTACGTGGTTCCAG	0.458000													24	40					6.32553e-13	1.13143e-12	0.004656	1	0
BNC1	646	broad.mit.edu	37	15	83932483	83932483	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:83932483A>T	ENST00000345382.2	-	4	1605	c.1520T>A	c.(1519-1521)aTa>aAa	p.I507K	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.I500K	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	507					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GGAAGGGAGTATCCCAGGCGT	0.517000													18	44					0	0	0.007413	0	0
CACNA1E	777	broad.mit.edu	37	1	181764047	181764047	+	Silent	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:181764047G>C	ENST00000526775.1	+	44	6054	c.5889G>C	c.(5887-5889)cgG>cgC	p.R1963R	CACNA1E_ENST00000367570.1_Silent_p.R1982R|CACNA1E_ENST00000357570.5_Silent_p.R1976R|CACNA1E_ENST00000358338.5_Silent_p.R1914R|CACNA1E_ENST00000367573.2_Silent_p.R2025R|CACNA1E_ENST00000360108.3_Silent_p.R2006R|CACNA1E_ENST00000367567.4_Silent_p.R1589R	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2025					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCACTATTCGGGATAAGCGTT	0.483000													23	30					0	0	0.002299	0	0
TULP4	56995	broad.mit.edu	37	6	158902193	158902193	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:158902193T>C	ENST00000367097.3	+	8	2715	c.1358T>C	c.(1357-1359)gTg>gCg	p.V453A	TULP4_ENST00000367094.2_Missense_Mutation_p.V453A	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	453					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GACCCGGAGGTGGGCGGCCCG	0.617000													11	56					0	0	0.008291	0	0
ANO1	55107	broad.mit.edu	37	11	70033898	70033898	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:70033898A>G	ENST00000355303.5	+	26	3054	c.2749A>G	c.(2749-2751)Aag>Gag	p.K917E	ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000398543.2_Missense_Mutation_p.K771E|ANO1_ENST00000531349.1_Missense_Mutation_p.K626E|ANO1_ENST00000538023.1_Missense_Mutation_p.K917E|ANO1_ENST00000530676.1_Missense_Mutation_p.K771E|ANO1-AS1_ENST00000524987.1_RNA	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	917					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						GGACATCCCCAAGGACATCAG	0.582000													4	12					0	0	0.000248	0	0
DOK5	55816	broad.mit.edu	37	20	53260108	53260108	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr20:53260108C>A	ENST00000262593.5	+	7	1197	c.847C>A	c.(847-849)Cgc>Agc	p.R283S	DOK5_ENST00000395939.1_Missense_Mutation_p.R175S	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	283							insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			ACAGCTCTACCGCTTGCAAGG	0.662000													10	29					1.58986e-06	2.25627e-06	0.008291	1	0
CKAP2L	150468	broad.mit.edu	37	2	113514765	113514765	+	Silent	SNP	G	G	C	rs145362538		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:113514765G>C	ENST00000302450.6	-	4	261	c.183C>G	c.(181-183)acC>acG	p.T61T	CKAP2L_ENST00000541405.1_5'UTR|CKAP2L_ENST00000481732.1_Intron	NM_152515.3	NP_689728.3	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	61						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						CAACATGGTTGGTAACATCAT	0.353000													10	134					0	0	0.001368	0	0
PIGS	94005	broad.mit.edu	37	17	26898184	26898184	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:26898184G>A	ENST00000308360.7	-	2	432	c.57C>T	c.(55-57)gcC>gcT	p.A19A	PIGS_ENST00000543734.1_Intron|PIGS_ENST00000395346.2_Silent_p.A11A	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	19					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					AGAAGAGGGCGGCGCGCTTGC	0.682000													11	25					0	0	0.001855	0	0
SCN10A	6336	broad.mit.edu	37	3	38797307	38797307	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:38797307C>T	ENST00000449082.2	-	10	1432	c.1433G>A	c.(1432-1434)cGc>cAc	p.R478H		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	478					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AGGATCAGAGCGGGGTGATTT	0.488000													11	172					0	0	0.001368	0	0
GPATCH2	55105	broad.mit.edu	37	1	217604634	217604634	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:217604634C>A	ENST00000366935.3	-	10	1550	c.1440G>T	c.(1438-1440)tgG>tgT	p.W480C		NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	480	G-patch.					intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		ACCCAGGCGTCCAGCCCATAT	0.463000													61	83					1.22119e-34	2.6192e-34	0.003610	1	0
ZNF721	170960	broad.mit.edu	37	4	436078	436078	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:436078T>A	ENST00000338977.5	-	2	2190	c.2142A>T	c.(2140-2142)aaA>aaT	p.K714N	ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000507078.1_Intron|ZNF721_ENST00000511833.2_Missense_Mutation_p.K726N					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						GATCTTCACATTTGTAGGGTT	0.393000													8	21					0	0	0.004482	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059651	152059651	+	Silent	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:152059651T>A	ENST00000368806.1	-	3	571	c.507A>T	c.(505-507)ccA>ccT	p.P169P		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	169							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATGCTTCTCCTGGAAAGTTGT	0.443000													36	58					0	0	0.004878	0	0
SLC16A1	6566	broad.mit.edu	37	1	113459922	113459922	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:113459922C>A	ENST00000538576.1	-	4	1937	c.1106G>T	c.(1105-1107)tGg>tTg	p.W369L	SLC16A1_ENST00000433570.4_Missense_Mutation_p.W369L|SLC16A1_ENST00000369626.3_Missense_Mutation_p.W369L	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	369					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	GGAGCTGAGCCACCCGAAGGC	0.488000													10	15					1.76689e-08	2.7732e-08	0.006214	1	0
ATRNL1	26033	broad.mit.edu	37	10	116919973	116919973	+	Silent	SNP	A	A	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:116919973A>C	ENST00000355044.3	+	6	1128	c.1002A>C	c.(1000-1002)ctA>ctC	p.L334L	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_Silent_p.L334L	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	334						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAATGGTCCTAAAGTAAGTAT	0.323000													33	73					0	0	0.003755	0	0
FAT2	2196	broad.mit.edu	37	5	150947298	150947298	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:150947298G>A	ENST00000261800.5	-	1	1207	c.1195C>T	c.(1195-1197)Cca>Tca	p.P399S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	399	Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTGAAGATGGCTTTAGAACA	0.498000													19	30					0	0	0.007413	0	0
AVEN	57099	broad.mit.edu	37	15	34295248	34295248	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:34295248G>T	ENST00000306730.3	-	2	559	c.430C>A	c.(430-432)Ctc>Atc	p.L144I	CHRM5_ENST00000383263.5_Intron	NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	144					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		GAGCTAAGGAGGACACTGAAA	0.353000													10	33					2.61681e-11	4.49409e-11	0.002450	1	0
NME7	29922	broad.mit.edu	37	1	169292473	169292473	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:169292473T>A	ENST00000367811.3	-	3	416	c.160A>T	c.(160-162)Aac>Tac	p.N54Y	NME7_ENST00000469474.1_5'UTR|NME7_ENST00000472647.1_Missense_Mutation_p.N18Y	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	54	DM10.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					AAGTGCAGGTTATCATATTTG	0.348000													20	164					0	0	0.002780	0	0
RYR2	6262	broad.mit.edu	37	1	237754280	237754280	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:237754280G>A	ENST00000366574.2	+	31	4465	c.4148G>A	c.(4147-4149)cGt>cAt	p.R1383H	RYR2_ENST00000360064.6_Missense_Mutation_p.R1381H|RYR2_ENST00000542537.1_Missense_Mutation_p.R1367H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1383	4 X approximate repeats.|B30.2/SPRY 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGCCCTCTCGTCTGAAACAA	0.398000													10	26					0	0	0.008291	0	0
VSTM1	284415	broad.mit.edu	37	19	54561782	54561782	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:54561782C>T	ENST00000338372.2	-	3	308	c.133G>A	c.(133-135)Gtg>Atg	p.V45M	VSTM1_ENST00000425006.2_Missense_Mutation_p.V45M|VSTM1_ENST00000376626.1_Missense_Mutation_p.V45M|VSTM1_ENST00000366170.2_Intron	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	45	Ig-like V-type.					integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TTCAGGGTCACATTGCTCTCG	0.522000													15	86					0	0	0.002450	0	0
NEURL4	84461	broad.mit.edu	37	17	7221650	7221650	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:7221650C>G	ENST00000399464.2	-	24	3905	c.3890G>C	c.(3889-3891)gGg>gCg	p.G1297A	NEURL4_ENST00000315614.7_Missense_Mutation_p.G1295A|NEURL4_ENST00000570460.1_Missense_Mutation_p.G1273A|NEURL4_ENST00000574120.1_5'UTR|RP11-542C16.2_ENST00000575474.1_Missense_Mutation_p.G111R	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACTGGCAGCCCCTGGCTCAGG	0.602000													49	73					0	0	0.003610	0	0
TENM2	57451	broad.mit.edu	37	5	167645193	167645193	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:167645193G>T	ENST00000519204.1	+	22	4052	c.3934G>T	c.(3934-3936)Gag>Tag	p.E1312*	TENM2_ENST00000518659.1_Nonsense_Mutation_p.E1433*|TENM2_ENST00000520394.1_Nonsense_Mutation_p.E1194*|TENM2_ENST00000403607.2_Nonsense_Mutation_p.E1257*|TENM2_ENST00000545108.1_Nonsense_Mutation_p.E1432*					teneurin transmembrane protein 2																		GTATGTTCTAGAGAACAATGT	0.493000													21	96					7.41877e-09	1.17217e-08	0.001882	1	0
EOMES	8320	broad.mit.edu	37	3	27758588	27758588	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:27758588C>A	ENST00000295743.4	-	6	2237	c.2034G>T	c.(2032-2034)ggG>ggT	p.G678G	EOMES_ENST00000449599.1_Silent_p.G697G|EOMES_ENST00000537516.1_Silent_p.G402G			O95936	EOMES_HUMAN	eomesodermin	678	Required for transcription activation (By similarity).				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						AAGCATAATACCCTCCCATGC	0.368000													7	54					0.00198382	0.00245517	0.001984	1	0
EML5	161436	broad.mit.edu	37	14	89205241	89205241	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:89205241T>C	ENST00000554922.1	-	6	1077	c.829A>G	c.(829-831)Aca>Gca	p.T277A	EML5_ENST00000380664.5_Missense_Mutation_p.T277A|EML5_ENST00000352093.5_Missense_Mutation_p.T277A	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	277						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCTGGTCTGTTTCCCTGAGA	0.363000													5	11					0	0	0.000602	0	0
PRR5	55615	broad.mit.edu	37	22	45110519	45110519	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:45110519C>A	ENST00000403581.1	+	4	861	c.252C>A	c.(250-252)gaC>gaA	p.D84E	PRR5-ARHGAP8_ENST00000352766.7_Missense_Mutation_p.D61E|ARHGAP8_ENST00000389773.5_Missense_Mutation_p.D52E|ARHGAP8_ENST00000517296.3_Missense_Mutation_p.D61E|PRR5_ENST00000477331.1_3'UTR|PRR5-ARHGAP8_ENST00000361473.5_Missense_Mutation_p.D61E|PRR5_ENST00000336985.6_Missense_Mutation_p.D61E	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GGCTGCCCGACCAGGAGCTCT	0.647000													13	45					6.72482e-11	1.11453e-10	0.003163	1	0
NPHS2	7827	broad.mit.edu	37	1	179521776	179521776	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:179521776C>A	ENST00000367615.4	-	7	903	c.835G>T	c.(835-837)Gct>Tct	p.A279S	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Missense_Mutation_p.A211S	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	279					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GCCTCCACAGCCAGTGAGTGC	0.522000													7	53					0.00621372	0.00751352	0.006214	1	0
POTEG	404785	broad.mit.edu	37	14	19553735	19553735	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:19553735C>T	ENST00000409832.3	+	1	371	c.319C>T	c.(319-321)Ccc>Tcc	p.P107S		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	107										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						CCACTGCTTCCCCTGCTGCAG	0.602000													78	895					0	0	0.003610	0	0
DNAH9	1770	broad.mit.edu	37	17	11666872	11666872	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:11666872G>C	ENST00000262442.3	+	36	7179	c.7111G>C	c.(7111-7113)Gag>Cag	p.E2371Q	DNAH9_ENST00000454412.2_Missense_Mutation_p.E2371Q	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2371					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAAATTTATGAGCATTATTT	0.498000													21	38					0	0	0.001523	0	0
SLC12A2	6558	broad.mit.edu	37	5	127488418	127488418	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:127488418A>T	ENST00000262461.2	+	15	2473	c.2284A>T	c.(2284-2286)Aca>Tca	p.T762S	SLC12A2_ENST00000343225.4_Missense_Mutation_p.T762S	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	762					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGGATCCTCTACACAAGCCCT	0.403000													13	67					0	0	0.002450	0	0
IL7R	3575	broad.mit.edu	37	5	35871289	35871289	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:35871289C>A	ENST00000303115.3	+	4	640	c.511C>A	c.(511-513)Cag>Aag	p.Q171K	IL7R_ENST00000506850.1_Missense_Mutation_p.Q171K|IL7R_ENST00000343305.4_Missense_Mutation_p.Q171K	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	171	Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGCTTACCGCCAGGAAAAGGA	0.348000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						10	30					5.50884e-06	7.50342e-06	0.001368	1	0
TM4SF18	116441	broad.mit.edu	37	3	149040216	149040216	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:149040216T>A	ENST00000296059.2	-	5	683	c.418A>T	c.(418-420)Aca>Tca	p.T140S	RP11-206M11.7_ENST00000489011.1_RNA|TM4SF18_ENST00000470080.1_Missense_Mutation_p.T140S	NM_138786.3	NP_620141.1	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	140						integral to membrane				lung(1)|ovary(1)|prostate(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTAGAATCTGTAAGGAAACTG	0.398000													7	22					0	0	0.006214	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238611	6238611	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:6238611C>G	ENST00000265978.4	-	9	2605	c.2247G>C	c.(2245-2247)caG>caC	p.Q749H	FAM160A2_ENST00000524416.1_Missense_Mutation_p.Q735H|FAM160A2_ENST00000449352.2_Missense_Mutation_p.Q735H	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	735					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CAGTGAAGGGCTGGCTTGGCA	0.567000													9	25					0	0	0.006214	0	0
TAF4	6874	broad.mit.edu	37	20	60581652	60581652	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr20:60581652C>T	ENST00000252996.3	-	7	2136	c.2137G>A	c.(2137-2139)Gtg>Atg	p.V713M	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	713					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GCACTGGTCACGGTGGCCGCC	0.726000													9	12					0	0	0.004482	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255495	140255495	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:140255495G>A	ENST00000398631.2	+	1	438	c.438G>A	c.(436-438)gcG>gcA	p.A146A	PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAATCTGCGCCTCTGGACT	0.483000													24	71					0	0	0.003330	0	0
DENND1B	163486	broad.mit.edu	37	1	197522116	197522116	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:197522116G>T	ENST00000235453.4	-	16	1463	c.1186C>A	c.(1186-1188)Caa>Aaa	p.Q396K	DENND1B_ENST00000367396.3_Missense_Mutation_p.Q426K|DENND1B_ENST00000400967.2_Missense_Mutation_p.Q396K			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	426						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						AATTGTTATTGAGAAAATGGA	0.318000													5	35					0.000602214	0.000769406	0.000602	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795344	142795344	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:142795344C>G	ENST00000370498.1	-	2	1087	c.334G>C	c.(334-336)Gac>Cac	p.D112H		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	112										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCTTCGTCCTCCTGTGAA	0.527000													48	384					0	0	0.003610	0	0
GOLGA4	2803	broad.mit.edu	37	3	37360619	37360619	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:37360619G>C	ENST00000361924.2	+	12	1853	c.1479G>C	c.(1477-1479)gaG>gaC	p.E493D	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.E515D|GOLGA4_ENST00000435830.2_3'UTR	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	493	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CCAGAAAAGAGCAGGAACTGA	0.383000													13	29					0	0	0.001368	0	0
IGLV3-32	28787	broad.mit.edu	37	22	22937243	22937243	+	RNA	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:22937243G>T	ENST00000390303.2	+	0	100																											TATTTCCTCTGGGCCAACTCA	0.562000											OREG0026367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					2.27111e-07	3.38524e-07	0.001368	1	0
NDRG4	65009	broad.mit.edu	37	16	58537747	58537747	+	Silent	SNP	C	C	A	rs145564006	byFrequency	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:58537747C>A	ENST00000394282.4	+	4	630	c.223C>A	c.(223-225)Cgg>Agg	p.R75R	NDRG4_ENST00000563799.1_Silent_p.R23R|NDRG4_ENST00000563022.1_3'UTR|NDRG4_ENST00000568640.1_Silent_p.R41R|NDRG4_ENST00000258187.5_Silent_p.R55R|NDRG4_ENST00000566192.1_Silent_p.R23R|NDRG4_ENST00000356752.4_Silent_p.R53R|NDRG4_ENST00000394279.2_Silent_p.R55R|NDRG4_ENST00000569923.1_5'UTR|NDRG4_ENST00000570248.1_Silent_p.R23R|NDRG4_ENST00000562999.1_Silent_p.R23R	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	23					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						TGTAGTGATCCGGGGCTCCCC	0.627000													22	20					1.85244e-09	2.98659e-09	0.003330	1	0
NEBL	10529	broad.mit.edu	37	10	21115394	21115394	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:21115394A>C	ENST00000377122.4	-	18	2247	c.1851T>G	c.(1849-1851)aaT>aaG	p.N617K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	617					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TATTCTGCTGATTTTTCTTCA	0.323000													8	90					0	0	0.006214	0	0
TSHB	7252	broad.mit.edu	37	1	115576107	115576107	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:115576107A>G	ENST00000256592.1	+	2	192	c.124A>G	c.(124-126)Atc>Gtc	p.I42V	TSHB_ENST00000369517.1_Missense_Mutation_p.I42V	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	42					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		TTGCCTAACCATCAACACCAC	0.418000													12	65					0	0	0.001368	0	0
NAV1	89796	broad.mit.edu	37	1	201749685	201749685	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:201749685G>A	ENST00000367296.4	+	4	1783	c.1363G>A	c.(1363-1365)Gtg>Atg	p.V455M	NAV1_ENST00000367297.4_Missense_Mutation_p.V455M|NAV1_ENST00000367295.1_Missense_Mutation_p.V64M|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Missense_Mutation_p.V455M|NAV1_ENST00000367302.1_Missense_Mutation_p.V468M|NAV1_ENST00000295624.6_Missense_Mutation_p.V455M	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	455					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CTCAACAATAGTGGTACGTGA	0.498000													21	65					0	0	0.003330	0	0
LPPR4	9890	broad.mit.edu	37	1	99771281	99771281	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:99771281G>A	ENST00000370185.3	+	7	1504	c.1007G>A	c.(1006-1008)aGt>aAt	p.S336N	LPPR4_ENST00000370184.1_Missense_Mutation_p.S178N|LPPR4_ENST00000457765.1_Missense_Mutation_p.S278N	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		336							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTGATGAGAGTATGTTTCAG	0.448000													11	96					0	0	0.001368	0	0
TEKT1	83659	broad.mit.edu	37	17	6718555	6718555	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:6718555C>T	ENST00000338694.2	-	5	685	c.556G>A	c.(556-558)Gat>Aat	p.D186N	TEKT1_ENST00000535086.1_Missense_Mutation_p.D40N	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	186					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				AAGCAGATATCATCTATGGTC	0.478000													20	71					0	0	0.002299	0	0
KRT6B	3854	broad.mit.edu	37	12	52845777	52845777	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:52845777C>A	ENST00000252252.3	-	1	133	c.86G>T	c.(85-87)aGc>aTc	p.S29I		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	29	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GCCAGAGCGGCTGACCCCAGG	0.647000													22	32					4.22769e-11	7.15688e-11	0.006320	1	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76877815	76877815	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:76877815C>A	ENST00000328299.3	+	3	484	c.336C>A	c.(334-336)acC>acA	p.T112T	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	112					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						ATGCCCCCACCAAAGGTTATG	0.453000													24	48					1.04121e-07	1.5972e-07	0.005443	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913735	77913735	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:77913735G>T	ENST00000321110.1	-	2	478	c.183C>A	c.(181-183)ccC>ccA	p.P61P		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	61	Pro-rich.						nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						GGAGCTTCTGGGGCTCCTTGG	0.567000													9	27					3.09899e-07	4.59037e-07	0.004482	1	0
RLIM	51132	broad.mit.edu	37	X	73811943	73811943	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:73811943G>T	ENST00000332687.6	-	4	1425	c.1207C>A	c.(1207-1209)Cag>Aag	p.Q403K	RLIM_ENST00000349225.2_Missense_Mutation_p.Q403K	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	403					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AACATGGTCTGAATTGCAACA	0.413000													13	74					2.27111e-07	3.38524e-07	0.001368	1	0
TRAPPC8	22878	broad.mit.edu	37	18	29447398	29447398	+	Silent	SNP	T	T	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:29447398T>G	ENST00000283351.4	-	17	2765	c.2430A>C	c.(2428-2430)tcA>tcC	p.S810S	TRAPPC8_ENST00000582539.1_Silent_p.S756S	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	810					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTAAGAACTCTGAAATAACTT	0.264000													6	15					0	0	0.004482	0	0
KRT31	3881	broad.mit.edu	37	17	39553599	39553599	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39553599C>G	ENST00000251645.2	-	1	245	c.193G>C	c.(193-195)Gac>Cac	p.D65H		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	65	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GCCAGGCGGTCGTTCAGGAAC	0.617000													40	97					0	0	0.003214	0	0
GPR141	353345	broad.mit.edu	37	7	37780252	37780252	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:37780252C>A	ENST00000447769.1	+	4	546	c.257C>A	c.(256-258)cCc>cAc	p.P86H	GPR141_ENST00000334425.1_Missense_Mutation_p.P86H|EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTTGGGCTGCCCTTCTGCAAA	0.483000													20	37					2.94398e-08	4.59029e-08	0.007413	1	0
CACNA1E	777	broad.mit.edu	37	1	181693670	181693670	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:181693670C>A	ENST00000526775.1	+	17	2304	c.2139C>A	c.(2137-2139)acC>acA	p.T713T	CACNA1E_ENST00000367570.1_Silent_p.T713T|CACNA1E_ENST00000357570.5_Silent_p.T664T|CACNA1E_ENST00000358338.5_Silent_p.T664T|CACNA1E_ENST00000367573.2_Silent_p.T713T|CACNA1E_ENST00000360108.3_Silent_p.T713T|CACNA1E_ENST00000367567.4_Silent_p.T320T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	713					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGAACTGACCAAGGTAAGCA	0.463000													7	18					1.06961e-07	1.63547e-07	0.003080	1	0
ZFHX4	79776	broad.mit.edu	37	8	77764905	77764905	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:77764905T>C	ENST00000521891.2	+	10	6196	c.5748T>C	c.(5746-5748)ttT>ttC	p.F1916F	ZFHX4_ENST00000455469.2_Silent_p.F1871F|ZFHX4_ENST00000050961.6_Silent_p.F1871F|ZFHX4_ENST00000518282.1_Silent_p.F1890F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1871						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGAAAACTTTGGTTTTGAAC	0.443000										HNSCC(33;0.089)			14	41					0	0	0.001855	0	0
NPHS2	7827	broad.mit.edu	37	1	179521777	179521777	+	Silent	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:179521777C>G	ENST00000367615.4	-	7	902	c.834G>C	c.(832-834)ctG>ctC	p.L278L	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Silent_p.L210L	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	278					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						CCTCCACAGCCAGTGAGTGCT	0.527000													7	51					0	0	0.006214	0	0
ARX	170302	broad.mit.edu	37	X	25031161	25031161	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:25031161G>T	ENST00000379044.4	-	2	1161	c.951C>A	c.(949-951)agC>agA	p.S317R		NM_139058.2	NP_620689.1	Q96QS3	ARX_HUMAN	aristaless related homeobox	317						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						CCTCCGAGTCGCTGCCCGCAG	0.662000													7	11					0.000157383	0.000206647	0.003080	1	0
BICD1	636	broad.mit.edu	37	12	32480553	32480553	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:32480553G>T	ENST00000548411.1	+	5	1345	c.1164G>T	c.(1162-1164)aaG>aaT	p.K388N	BICD1_ENST00000281474.5_Missense_Mutation_p.K388N	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	388					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGGAGCTCAAGGCTGAGCTGG	0.587000													10	15					0.000442599	0.000571641	0.006214	1	0
SCD	6319	broad.mit.edu	37	10	102107276	102107276	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:102107276G>T	ENST00000370355.2	+	1	396	c.15G>T	c.(13-15)ttG>ttT	p.L5F		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	5				L -> M (in Ref. 11; AAB30631).	fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		CGGCCCACTTGCTGCAGGACG	0.682000													12	35					2.31682e-05	3.11981e-05	0.003163	1	0
API5	8539	broad.mit.edu	37	11	43340233	43340233	+	Missense_Mutation	SNP	G	G	A	rs35999189		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:43340233G>A	ENST00000378852.3	+	2	238	c.113G>A	c.(112-114)gGt>gAt	p.G38D	API5_ENST00000420461.2_Intron|API5_ENST00000455725.2_Missense_Mutation_p.G27D|API5_ENST00000534695.1_Missense_Mutation_p.G38D|API5_ENST00000534600.1_Missense_Mutation_p.G38D|API5_ENST00000531273.1_Missense_Mutation_p.G38D	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	38					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						GTGAAAGGTGGTACTAAGGAA	0.368000													16	43					0	0	0.004007	0	0
GPM6A	2823	broad.mit.edu	37	4	176594959	176594959	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:176594959C>G	ENST00000280187.7	-	4	304	c.259G>C	c.(259-261)Ggc>Cgc	p.G87R	GPM6A_ENST00000506894.1_Missense_Mutation_p.G76R|GPM6A_ENST00000515090.1_Missense_Mutation_p.G80R|GPM6A_ENST00000393658.2_Missense_Mutation_p.G87R	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	87						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GCTGCGATGCCGTAGATCACA	0.398000													6	14					0	0	0.001168	0	0
SLC34A2	10568	broad.mit.edu	37	4	25669599	25669599	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:25669599G>A	ENST00000382051.3	+	6	671	c.621G>A	c.(619-621)cgG>cgA	p.R207R	SLC34A2_ENST00000510033.2_3'UTR|SLC34A2_ENST00000504570.1_Silent_p.R206R|SLC34A2_ENST00000503434.1_Silent_p.R206R	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	207					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGGGAGATCGGAGTGAGTTCA	0.498000			T	ROS1	NSCLC								34	11					0	0	0.005524	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917135	42917135	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:42917135C>T	ENST00000316161.4	-	1	498	c.174G>A	c.(172-174)aaG>aaA	p.K58K	KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.K58K|ACKR2_ENST00000471537.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	58					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TCCTCATGCGCTTCAGAAATT	0.572000													17	26					0	0	0.006122	0	0
TRIM3	10612	broad.mit.edu	37	11	6478952	6478952	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:6478952C>A	ENST00000525074.1	-	4	883	c.489G>T	c.(487-489)caG>caT	p.Q163H	TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000537602.1_Missense_Mutation_p.Q163H|TRIM3_ENST00000345851.3_Missense_Mutation_p.Q163H|TRIM3_ENST00000359518.3_Missense_Mutation_p.Q163H|TRIM3_ENST00000536344.1_Missense_Mutation_p.Q44H	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	163					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGAGCTGGCGCTGCAGGGCCG	0.677000													15	41					3.27435e-08	5.08867e-08	0.002450	1	0
CELSR1	9620	broad.mit.edu	37	22	46762935	46762935	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:46762935C>A	ENST00000262738.3	-	29	8159	c.8160G>T	c.(8158-8160)aaG>aaT	p.K2720N		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2720					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCAGGTGCAGCTTCCTCCCGC	0.706000											OREG0026655	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	11					1.12685e-05	1.53045e-05	0.004482	1	0
DDX11	1663	broad.mit.edu	37	12	31242051	31242051	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:31242051A>T	ENST00000407793.2	+	7	1009	c.758A>T	c.(757-759)aAg>aTg	p.K253M	DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_Missense_Mutation_p.K227M|DDX11_ENST00000545668.1_Missense_Mutation_p.K253M|DDX11_ENST00000542838.1_Missense_Mutation_p.K253M|DDX11_ENST00000350437.4_Missense_Mutation_p.K253M	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	253	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CCCTTTGGCAAGGATGTTCGG	0.537000										Multiple Myeloma(12;0.14)			20	44					0	0	0.002299	0	0
FAM49A	81553	broad.mit.edu	37	2	16742303	16742303	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:16742303C>G	ENST00000381323.3	-	9	885	c.665G>C	c.(664-666)tGc>tCc	p.C222S	FAM49A_ENST00000406434.1_Missense_Mutation_p.C222S|FAM49A_ENST00000355549.2_Missense_Mutation_p.C222S	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	222						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TGTGCTGAGGCAGTCTGTGGT	0.428000													15	43					0	0	0.006122	0	0
C12orf40	283461	broad.mit.edu	37	12	40115022	40115022	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:40115022C>A	ENST00000324616.5	+	13	2082	c.1928C>A	c.(1927-1929)aCt>aAt	p.T643N		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	643										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						GCAGATACCACTGGAGGGCAG	0.358000													14	28					1.3612e-06	1.94928e-06	0.003163	1	0
FAT2	2196	broad.mit.edu	37	5	150928985	150928985	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:150928985G>T	ENST00000261800.5	-	8	4672	c.4660C>A	c.(4660-4662)Cgc>Agc	p.R1554S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1554	Cadherin 13.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAGTGAAGCGGGGTGGGTGG	0.572000													9	35					1.58986e-06	2.25627e-06	0.008291	1	0
MYH10	4628	broad.mit.edu	37	17	8455408	8455408	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:8455408T>C	ENST00000360416.3	-	9	1013	c.875A>G	c.(874-876)cAt>cGt	p.H292R	MYH10_ENST00000379980.4_Missense_Mutation_p.H298R|MYH10_ENST00000269243.4_Missense_Mutation_p.H282R|MYH10_ENST00000396239.1_Missense_Mutation_p.H282R	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	282	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GTAAAAGATATGAAAAGTACG	0.303000													5	17					0	0	0.001984	0	0
SYT13	57586	broad.mit.edu	37	11	45277237	45277237	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:45277237A>T	ENST00000020926.3	-	2	500	c.389T>A	c.(388-390)cTg>cAg	p.L130Q		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	130						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GAGGATGAACAGCTCCTCTGT	0.582000													6	25					0	0	0.001984	0	0
USP48	84196	broad.mit.edu	37	1	22078009	22078009	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:22078009T>C	ENST00000308271.9	-	6	1413	c.765A>G	c.(763-765)gaA>gaG	p.E255E	USP48_ENST00000529637.1_Silent_p.E255E|USP48_ENST00000421625.2_Silent_p.E255E|USP48_ENST00000400301.1_Silent_p.E255E	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	255					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		CCTTCAAAAATTCCGAGATAC	0.368000													8	76					0	0	0.004482	0	0
HOXA10	3206	broad.mit.edu	37	7	27213842	27213842	+	Silent	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:27213842A>G	ENST00000283921.4	-	1	83	c.84T>C	c.(82-84)tcT>tcC	p.S28S	RP1-170O19.20_ENST00000470747.4_Intron|RP1-170O19.20_ENST00000465941.1_Intron|HOXA10_ENST00000396344.4_Intron	NM_018951.3	NP_061824.3	P31260	HXA10_HUMAN	homeobox A10	28					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	9						CGACCAAAAAAGAGTTCGCGG	0.622000													12	30					0	0	0.004990	0	0
ZWINT	11130	broad.mit.edu	37	10	58119454	58119454	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:58119454C>A	ENST00000373944.3	-	4	455	c.417G>T	c.(415-417)caG>caT	p.Q139H	ZWINT_ENST00000318387.2_Missense_Mutation_p.Q19H|ZWINT_ENST00000361148.6_Missense_Mutation_p.Q139H|ZWINT_ENST00000460654.1_5'UTR|ZWINT_ENST00000395405.1_Missense_Mutation_p.Q139H			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	139	Interaction with NDC80 and ZW10.				cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						GTACCTTGGCCTGGAGCTGCT	0.552000													20	212					4.30721e-22	8.87659e-22	0.001523	1	0
FBXL4	26235	broad.mit.edu	37	6	99374673	99374673	+	Silent	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:99374673A>G	ENST00000369244.2	-	4	620	c.192T>C	c.(190-192)caT>caC	p.H64H	FBXL4_ENST00000229971.1_Silent_p.H64H			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	64					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		CACTTCCATAATGGGAACTGA	0.423000													29	72					0	0	0.002096	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840205	27840205	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:27840205A>T	ENST00000356790.2	+	3	1027	c.782A>T	c.(781-783)cAg>cTg	p.Q261L		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	261	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CTGGAGTACCAGCAAGTGCCC	0.473000													6	47					0	0	0.001168	0	0
JAG1	182	broad.mit.edu	37	20	10623158	10623158	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr20:10623158G>C	ENST00000254958.5	-	21	3065	c.2550C>G	c.(2548-2550)caC>caG	p.H850Q	JAG1_ENST00000423891.2_Missense_Mutation_p.H691Q	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	850	EGF-like 16; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						TGGCACCACTGTGCCCTGGAG	0.537000									Alagille Syndrome				3	27					0	0	0.004672	0	0
CSMD3	114788	broad.mit.edu	37	8	113697849	113697849	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:113697849C>A	ENST00000297405.5	-	15	2512	c.2268G>T	c.(2266-2268)ggG>ggT	p.G756G	CSMD3_ENST00000455883.2_Silent_p.G652G|CSMD3_ENST00000352409.3_Silent_p.G756G|CSMD3_ENST00000343508.3_Silent_p.G716G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	756	CUB 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTATCCGGCTCCCTGGATCAG	0.413000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			73	48					2.10938e-32	4.48361e-32	0.003610	1	0
HERC2	8924	broad.mit.edu	37	15	28465650	28465650	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:28465650C>T	ENST00000261609.7	-	37	5901	c.5793G>A	c.(5791-5793)ctG>ctA	p.L1931L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1931	MIB/HERC2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGCAGCCGGCAGCTCTGCCA	0.562000													40	122					0	0	0.008740	0	0
OR52M1	119772	broad.mit.edu	37	11	4566822	4566822	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:4566822T>C	ENST00000360213.1	+	1	402	c.402T>C	c.(400-402)caT>caC	p.H134H		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACTACGTCATAGCATGGTGC	0.527000													9	49					0	0	0.004482	0	0
VCAM1	7412	broad.mit.edu	37	1	101188624	101188624	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:101188624G>A	ENST00000294728.2	+	3	490	c.389G>A	c.(388-390)gGg>gAg	p.G130E	VCAM1_ENST00000347652.2_Missense_Mutation_p.G130E|VCAM1_ENST00000370115.1_Missense_Mutation_p.G130E|VCAM1_ENST00000370119.4_Missense_Mutation_p.G68E	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	130	Ig-like C2-type 2.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CTGGAGGCTGGGAAGCCGATC	0.438000													8	25					0	0	0.003080	0	0
NALCN	259232	broad.mit.edu	37	13	101728232	101728232	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:101728232C>A	ENST00000251127.6	-	35	4027	c.3946G>T	c.(3946-3948)Gga>Tga	p.G1316*		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1316						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACATGTTTTCCACAGATGGAG	0.323000													27	36					1.61788e-16	3.11738e-16	0.002445	1	0
CERS1	10715	broad.mit.edu	37	19	18989736	18989736	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:18989736C>T	ENST00000429504.2	-	6	1075	c.1013G>A	c.(1012-1014)tGa>tAa	p.*338*	GDF1_ENST00000247005.6_Intron|CERS1_ENST00000427170.2_Intron|CERS1_ENST00000542296.2_Silent_p.*240*	NM_198207.2	NP_937850.1	P27544	CERS1_HUMAN	ceramide synthase 1	0					ceramide biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|microsome	sphingosine N-acyltransferase activity			endometrium(3)|lung(2)	5						CCTCCACACTCACTCGGCTTT	0.642000													6	12					0	0	0.001168	0	0
SCN4A	6329	broad.mit.edu	37	17	62020280	62020280	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:62020280C>T	ENST00000578147.1	-	23	4270	c.4194G>A	c.(4192-4194)ggG>ggA	p.G1398G	SCN4A_ENST00000435607.1_Silent_p.G1398G			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1398					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCACGCACTCCCCTGTGAAGA	0.517000													34	61					0	0	0.003755	0	0
XKR9	389668	broad.mit.edu	37	8	71646419	71646419	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:71646419G>T	ENST00000408926.3	+	5	1416	c.882G>T	c.(880-882)agG>agT	p.R294S	XKR9_ENST00000520273.1_Intron|XKR9_ENST00000520030.1_Missense_Mutation_p.R294S	NM_001011720.1	NP_001011720.1	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related family, member 9	294						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			ATATTGTTAGGGTACTGGGCA	0.323000													9	43					0.000442599	0.000571641	0.006214	1	0
PPP1R21	129285	broad.mit.edu	37	2	48725646	48725646	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:48725646G>T	ENST00000294952.8	+	17	1864	c.1707G>T	c.(1705-1707)ttG>ttT	p.L569F	PPP1R21_ENST00000449090.2_Missense_Mutation_p.L538F|PPP1R21_ENST00000281394.4_Missense_Mutation_p.L569F	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	569										endometrium(2)|kidney(4)|lung(9)	15						AACAGAGTTTGGAAAAGATTT	0.358000													12	16					5.50884e-06	7.50342e-06	0.001368	1	0
GSDMB	55876	broad.mit.edu	37	17	38062503	38062503	+	Missense_Mutation	SNP	T	T	C	rs35104165	byFrequency	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:38062503T>C	ENST00000394175.2	-	5	906	c.683A>G	c.(682-684)gAt>gGt	p.D228G	GSDMB_ENST00000309481.7_Missense_Mutation_p.D237G|GSDMB_ENST00000418519.1_Missense_Mutation_p.D250G|GSDMB_ENST00000394179.1_Missense_Mutation_p.D245G|GSDMB_ENST00000520542.1_Missense_Mutation_p.D241G|GSDMB_ENST00000360317.3_Missense_Mutation_p.D250G	NM_018530.2	NP_061000.2	Q8TAX9	GSDMB_HUMAN	gasdermin B	245						cytoplasm		p.D228G(2)		breast(2)|endometrium(3)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|stomach(2)	21						GTTTCTGGAATCCTCCGAACC	0.478000													6	71					0	0	0.001984	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162584	33162584	+	RNA	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:33162584G>T	ENST00000510327.1	-	0	346																											GTGAAGAATTGCATCGTGCTC	0.522000													15	19					1.15088e-07	1.73731e-07	0.004007	1	0
HPN	3249	broad.mit.edu	37	19	35551631	35551631	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:35551631G>T	ENST00000262626.2	+	9	1546	c.721G>T	c.(721-723)Ggg>Tgg	p.G241W	HPN_ENST00000597419.1_Missense_Mutation_p.G83W|HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000392226.1_Missense_Mutation_p.G241W	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	241	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GGTCTACCACGGGGGCTATCT	0.642000													16	61					8.60227e-14	1.56225e-13	0.004007	1	0
ASPDH	554235	broad.mit.edu	37	19	51015483	51015483	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:51015483A>T	ENST00000389208.4	-	6	779	c.718T>A	c.(718-720)Ttt>Att	p.F240I	ASPDH_ENST00000597030.1_5'UTR|ASPDH_ENST00000376916.3_Missense_Mutation_p.F135I	NM_001114598.1	NP_001108070.1	A6ND91	ASPD_HUMAN	aspartate dehydrogenase domain containing	240					NAD biosynthetic process|NADP catabolic process		aspartate dehydrogenase activity|NADP binding			endometrium(1)|large_intestine(1)|lung(1)	3						TGCACAGCAAAGCTTCGGCCC	0.692000													4	20					0	0	0.000602	0	0
ASPM	259266	broad.mit.edu	37	1	197062214	197062214	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:197062214C>T	ENST00000367409.4	-	21	9518	c.9262G>A	c.(9262-9264)Gca>Aca	p.A3088T	ASPM_ENST00000294732.7_Missense_Mutation_p.A1503T|ASPM_ENST00000367408.1_Missense_Mutation_p.A753T	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3088	IQ 37.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CGCACCAGTGCTTGTAGGATA	0.333000													27	27					0	0	0.008361	0	0
KRT40	125115	broad.mit.edu	37	17	39138696	39138696	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39138696G>T	ENST00000377755.4	-	3	584	c.550C>A	c.(550-552)Ctt>Att	p.L184I	KRT40_ENST00000398486.2_Missense_Mutation_p.L184I			Q6A162	K1C40_HUMAN	keratin 40	184	Coil 1B.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				AGCTGGCGAAGGGACAGTTCA	0.517000													34	57					1.30998e-17	2.57648e-17	0.005524	1	0
G6PC	2538	broad.mit.edu	37	17	41063145	41063145	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:41063145C>A	ENST00000253801.2	+	5	855	c.776C>A	c.(775-777)gCc>gAc	p.A259D	G6PC_ENST00000585489.1_3'UTR|G6PC_ENST00000592383.1_3'UTR	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	259					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ACACCCTTTGCCAGCCTCCTC	0.592000													15	32					0.00316338	0.00386454	0.003163	1	0
SNHG14	104472715	broad.mit.edu	37	15	25453123	25453123	+	RNA	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:25453123G>T	ENST00000424208.1	+	0	2384				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						AGCTCCTGATGCACTGAAGCT	0.617000													4	46					2.56e-06	3.59006e-06	0.000248	1	0
RPF1	80135	broad.mit.edu	37	1	84956127	84956127	+	Silent	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:84956127T>A	ENST00000370654.5	+	5	603	c.588T>A	c.(586-588)atT>atA	p.I196I		NM_025065.6	NP_079341.2	Q9H9Y2	RPF1_HUMAN	ribosome production factor 1 homolog (S. cerevisiae)	196	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(2)|prostate(1)	14						CAGACCTGATTGTTATTAATG	0.358000													17	33					0	0	0.008871	0	0
HHIPL1	84439	broad.mit.edu	37	14	100129283	100129283	+	Missense_Mutation	SNP	G	G	T	rs142621182		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:100129283G>T	ENST00000330710.5	+	6	1671	c.1573G>T	c.(1573-1575)Ggc>Tgc	p.G525C	HHIPL1_ENST00000357223.2_Missense_Mutation_p.G525C	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	525					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				CATGGGCCACGGCCAGACCTG	0.582000													17	60					3.52763e-06	4.91793e-06	0.004990	1	0
PAPL	390928	broad.mit.edu	37	19	39592142	39592142	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:39592142C>A	ENST00000331256.5	+	11	1352	c.1078C>A	c.(1078-1080)Ccg>Acg	p.P360T	PAPL_ENST00000594229.1_Silent_p.T318T	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		360						extracellular region	acid phosphatase activity|metal ion binding										CTACACCAACCCGCGAGGGCC	0.572000													12	13					0.00316338	0.00386454	0.003163	1	0
VRK1	7443	broad.mit.edu	37	14	97321607	97321607	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:97321607G>T	ENST00000216639.3	+	8	772	c.623G>T	c.(622-624)gGa>gTa	p.G208V		NM_003384.2	NP_003375.1	Q99986	VRK1_HUMAN	vaccinia related kinase 1	208	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(1)|stomach(1)	12		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		TGCCCAGAAGGAGTTCATAAA	0.408000													10	86					1.33987e-11	2.30945e-11	0.008291	1	0
B4GALT6	9331	broad.mit.edu	37	18	29205658	29205658	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:29205658C>A	ENST00000306851.5	-	9	1364	c.1068G>T	c.(1066-1068)agG>agT	p.R356S	B4GALT6_ENST00000237019.7_Missense_Mutation_p.R317S|B4GALT6_ENST00000383131.3_Missense_Mutation_p.R317S	NM_004775.3	NP_004766.2	Q9UBX8	B4GT6_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	356					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(6)|pancreas(1)	20			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			GTATTTTTGGCCTATATATTA	0.358000													16	25					1.99824e-07	3.00687e-07	0.004990	1	0
FAM27L	284123	broad.mit.edu	37	17	21825561	21825561	+	RNA	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:21825561C>A	ENST00000426869.3	+	0	265					NR_028336.1				family with sequence similarity 27-like									p.R21W(1)		central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		caggcctgcccggagggtgtt	0.632000													17	46					2.4624e-09	3.9167e-09	0.008871	1	0
USH2A	7399	broad.mit.edu	37	1	216270486	216270486	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:216270486T>A	ENST00000366943.2	-	22	5083	c.4697A>T	c.(4696-4698)cAg>cTg	p.Q1566L	USH2A_ENST00000307340.3_Missense_Mutation_p.Q1566L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1566	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATACTCTTCCTGATTGCCAGG	0.368000										HNSCC(13;0.011)			6	43					0	0	0.001984	0	0
KREMEN1	83999	broad.mit.edu	37	22	29521313	29521313	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:29521313C>T	ENST00000400338.2	+	5	593	c.540C>T	c.(538-540)taC>taT	p.Y180Y	KREMEN1_ENST00000327813.5_Silent_p.Y180Y|KREMEN1_ENST00000400335.4_Silent_p.Y180Y|KREMEN1_ENST00000407188.1_Silent_p.Y178Y			Q96MU8	KREM1_HUMAN	kringle containing transmembrane protein 1	178	WSC.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			breast(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	20						ACTGGAAGTACGGGGAGGCAG	0.527000													54	74					0	0	0.003610	0	0
SLC35G5	83650	broad.mit.edu	37	8	11189615	11189615	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:11189615G>T	ENST00000382435.4	+	1	1219	c.1000G>T	c.(1000-1002)Ggg>Tgg	p.G334W		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	334						integral to membrane											TGAGAGGACAGGGAAGGTGGA	0.502000													27	43					2.44723e-14	4.47872e-14	0.004656	1	0
MMP16	4325	broad.mit.edu	37	8	89198727	89198727	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:89198727G>T	ENST00000286614.6	-	3	663	c.382C>A	c.(382-384)Cag>Aag	p.Q128K	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	128					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TGCTTGTGCTGCCATTTCTGT	0.418000													39	200					4.92203e-23	1.01879e-22	0.006230	1	0
TACC2	10579	broad.mit.edu	37	10	123987490	123987490	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:123987490G>T	ENST00000369005.1	+	14	8203	c.7863G>T	c.(7861-7863)atG>atT	p.M2621I	TACC2_ENST00000360561.3_Missense_Mutation_p.M699I|TACC2_ENST00000368999.1_Missense_Mutation_p.M711I|TACC2_ENST00000369001.1_Missense_Mutation_p.M325I|TACC2_ENST00000515603.1_Missense_Mutation_p.M2576I|TACC2_ENST00000453444.2_Missense_Mutation_p.M2625I|TACC2_ENST00000260733.3_Missense_Mutation_p.M699I|TACC2_ENST00000515273.1_Missense_Mutation_p.M2625I|TACC2_ENST00000513429.1_Missense_Mutation_p.M767I|TACC2_ENST00000334433.3_Missense_Mutation_p.M2621I|TACC2_ENST00000369000.1_Missense_Mutation_p.M321I|TACC2_ENST00000358010.1_Missense_Mutation_p.M767I|TACC2_ENST00000369004.3_Missense_Mutation_p.M711I	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2621						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGGAGGCCATGGGCTTGGGCA	0.567000													21	76					2.89027e-11	4.91035e-11	0.002299	1	0
OR4S1	256148	broad.mit.edu	37	11	48328158	48328158	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:48328158G>T	ENST00000319988.1	+	1	384	c.384G>T	c.(382-384)ctG>ctT	p.L128L		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						GTAGGCCCCTGCACTACACAG	0.582000													25	66					9.80776e-20	1.99523e-19	0.006320	1	0
PARK2	5071	broad.mit.edu	37	6	162683557	162683557	+	Splice_Site	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:162683557C>G	ENST00000366898.1	-	3	514	c.412_splice	c.e3+1	p.A138_splice	PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366897.1_Splice_Site_p.A138_splice|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366894.1_Intron|PARK2_ENST00000366892.1_Splice_Site_p.A138_splice	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	138					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTCCAATTACCTGGACTTCCA	0.488000													10	47					0	0	0.008291	0	0
LRP1B	53353	broad.mit.edu	37	2	141130675	141130675	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:141130675T>A	ENST00000389484.3	-	69	11641	c.10670A>T	c.(10669-10671)cAg>cTg	p.Q3557L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3557	LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACACCGGAACTGATCTTTGGA	0.368000										TSP Lung(27;0.18)			27	38					0	0	0.005443	0	0
ZNF346	23567	broad.mit.edu	37	5	176471400	176471400	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:176471400G>T	ENST00000503039.1	+	5	462	c.458G>T	c.(457-459)aGa>aTa	p.R153I	ZNF346_ENST00000512315.1_Intron|ZNF346_ENST00000503425.1_Missense_Mutation_p.R96I|ZNF346_ENST00000511834.1_Missense_Mutation_p.R128I|ZNF346_ENST00000358149.3_Missense_Mutation_p.R128I|ZNF346_ENST00000506693.1_Intron|ZNF346_ENST00000261948.4_Missense_Mutation_p.R153I			Q9UL40	ZN346_HUMAN	zinc finger protein 346	128						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	14	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGAGCAGCAGAAGCAAAGAC	0.522000													21	40					2.37509e-13	4.28058e-13	0.001523	1	0
SPATA13	221178	broad.mit.edu	37	13	24876744	24876744	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:24876744A>T	ENST00000424834.2	+	15	4140	c.3667A>T	c.(3667-3669)Agg>Tgg	p.R1223W	SPATA13_ENST00000382095.4_Missense_Mutation_p.R598W|SPATA13_ENST00000382108.3_Missense_Mutation_p.R1223W|SPATA13_ENST00000409126.1_Missense_Mutation_p.R458W|SPATA13_ENST00000343003.6_Missense_Mutation_p.R542W|SPATA13_ENST00000399949.2_Missense_Mutation_p.R520W			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	598					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		AGGCTACAACAGGTGCCCTGT	0.582000													20	85					0	0	0.002780	0	0
OR4C46	119749	broad.mit.edu	37	11	51515998	51515998	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:51515998C>A	ENST00000328188.1	+	1	717	c.717C>A	c.(715-717)gtC>gtA	p.V239V		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						CCACCTGTGTCTCCCACATCA	0.463000													7	64					6.5536e-12	1.14628e-11	0.003080	1	0
MYO7A	4647	broad.mit.edu	37	11	76892594	76892594	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:76892594G>T	ENST00000409709.3	+	23	3135	c.2863G>T	c.(2863-2865)Ggc>Tgc	p.G955C	MYO7A_ENST00000409893.1_Missense_Mutation_p.G955C|MYO7A_ENST00000409619.2_Missense_Mutation_p.G944C|MYO7A_ENST00000458637.2_Missense_Mutation_p.G955C	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	955			G -> S (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GACTTCAGGTGGCCTGCCAGG	0.602000													7	22					5.18039e-06	7.09684e-06	0.003080	1	0
NALCN	259232	broad.mit.edu	37	13	101728231	101728231	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:101728231C>G	ENST00000251127.6	-	35	4028	c.3947G>C	c.(3946-3948)gGa>gCa	p.G1316A		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1316						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TACATGTTTTCCACAGATGGA	0.323000													25	36					0	0	0.001786	0	0
FBXL4	26235	broad.mit.edu	37	6	99374672	99374672	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:99374672A>T	ENST00000369244.2	-	4	621	c.193T>A	c.(193-195)Tat>Aat	p.Y65N	FBXL4_ENST00000229971.1_Missense_Mutation_p.Y65N			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	65					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		TCACTTCCATAATGGGAACTG	0.428000													28	72					0	0	0.001786	0	0
GALP	85569	broad.mit.edu	37	19	56691994	56691994	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:56691994C>T	ENST00000357330.2	+	3	209	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L	GALP_ENST00000590002.1_Intron|GALP_ENST00000440823.1_Intron	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	43					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		TGGCTACCTTCTGGGTCCCGG	0.592000													13	31					0	0	0.001855	0	0
SLC35G1	159371	broad.mit.edu	37	10	95661084	95661084	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:95661084G>T	ENST00000371408.3	+	3	993	c.932G>T	c.(931-933)gGg>gTg	p.G311V	SLC35G1_ENST00000427197.1_Missense_Mutation_p.G312V			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	312	DUF6 2.					integral to membrane											GAAAAAGCAGGGCCAGTAGCA	0.408000													14	32					0.00185496	0.00232606	0.001855	1	0
MYO7A	4647	broad.mit.edu	37	11	76924959	76924959	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:76924959A>G	ENST00000409709.3	+	48	6765	c.6493A>G	c.(6493-6495)Acc>Gcc	p.T2165A	MYO7A_ENST00000409619.2_Missense_Mutation_p.T2116A|MYO7A_ENST00000605744.1_3'UTR|MYO7A_ENST00000458637.2_Missense_Mutation_p.T2125A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	2165	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CAGCGGCAACACCTACTTCCA	0.607000													25	100					0	0	0.007291	0	0
DMXL1	1657	broad.mit.edu	37	5	118440930	118440930	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:118440930A>G	ENST00000311085.8	+	4	421	c.341A>G	c.(340-342)cAc>cGc	p.H114R	DMXL1_ENST00000539542.1_Missense_Mutation_p.H114R	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	114										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TCAATAGCACACAATATAACC	0.308000													6	13					0	0	0.001984	0	0
COL6A6	131873	broad.mit.edu	37	3	130290003	130290003	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:130290003C>A	ENST00000358511.6	+	6	2774	c.2743C>A	c.(2743-2745)Ctc>Atc	p.L915I	COL6A6_ENST00000453409.2_Missense_Mutation_p.L915I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	915	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CCCCCAAGTCCTCATTGTGAT	0.562000													17	15					0.00400662	0.00488211	0.004007	1	0
KAL1	3730	broad.mit.edu	37	X	8507735	8507735	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:8507735G>A	ENST00000262648.3	-	10	1568	c.1419C>T	c.(1417-1419)acC>acT	p.T473T		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	473	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						CCTCTGATCCGGTTGTTCTGT	0.453000													6	56					0	0	0.001168	0	0
CPD	1362	broad.mit.edu	37	17	28747973	28747973	+	Missense_Mutation	SNP	G	G	A	rs147588955	byFrequency	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:28747973G>A	ENST00000225719.4	+	3	1185	c.1109G>A	c.(1108-1110)cGt>cAt	p.R370H	CPD_ENST00000543464.2_Missense_Mutation_p.R123H	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	370	Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						GAGAACAATCGTGAGTCTTTG	0.398000													10	27					0	0	0.006214	0	0
MCC	4163	broad.mit.edu	37	5	112418664	112418664	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:112418664C>G	ENST00000302475.4	-	9	1670	c.1107G>C	c.(1105-1107)caG>caC	p.Q369H	MCC_ENST00000515367.2_Missense_Mutation_p.Q306H|MCC_ENST00000514701.3_5'UTR|MCC_ENST00000408903.3_Missense_Mutation_p.Q559H	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	369					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TGGAGCAGTCCTGAAGTGAGT	0.448000													19	29					0	0	0.008871	0	0
ABCC11	85320	broad.mit.edu	37	16	48249175	48249175	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:48249175T>A	ENST00000394747.1	-	7	1381	c.1032A>T	c.(1030-1032)gaA>gaT	p.E344D	ABCC11_ENST00000537808.1_Missense_Mutation_p.E344D|ABCC11_ENST00000394748.1_Missense_Mutation_p.E344D|ABCC11_ENST00000353782.5_Missense_Mutation_p.E344D|ABCC11_ENST00000356608.2_Missense_Mutation_p.E344D	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	344	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AAGTGAGAACTTCACTGGTCA	0.448000													6	64					0	0	0.001168	0	0
PFAS	5198	broad.mit.edu	37	17	8172508	8172508	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:8172508G>T	ENST00000314666.6	+	28	4076	c.3943G>T	c.(3943-3945)Gat>Tat	p.D1315Y	PFAS_ENST00000545834.1_Missense_Mutation_p.D891Y	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1315					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCCTCCATTTGATACTCTGAC	0.642000													13	31					0.000151284	0.000200865	0.001855	1	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796704	62796704	+	RNA	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:62796704G>A	ENST00000582986.1	-	0	1216					NR_024386.1																						AGTACTGCACGTTCACCCACT	0.697000													16	32					0	0	0.004990	0	0
CACNA1S	779	broad.mit.edu	37	1	201046253	201046253	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:201046253T>A	ENST00000362061.3	-	12	1848	c.1622A>T	c.(1621-1623)tAt>tTt	p.Y541F	CACNA1S_ENST00000367338.3_Missense_Mutation_p.Y541F	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	541					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CGACGTCCAATATCTGAAGGA	0.592000													5	35					0	0	0.001168	0	0
FAM73A	374986	broad.mit.edu	37	1	78269059	78269059	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:78269059A>T	ENST00000370791.3	+	4	510	c.478A>T	c.(478-480)Aaa>Taa	p.K160*	FAM73A_ENST00000443751.2_Nonsense_Mutation_p.K122*	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	160						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		ACTTTTCAGTAAATATTCAGG	0.303000													11	14					0	0	0.001368	0	0
ABCC6P1	653190	broad.mit.edu	37	16	18603969	18603969	+	RNA	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:18603969G>A	ENST00000546162.2	+	0	1312					NR_003569.1																						TTGAGCAGCAGAACATGTACA	0.587000													9	28					0	0	0.006214	0	0
C11orf40	143501	broad.mit.edu	37	11	4594548	4594548	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:4594548C>A	ENST00000307616.1	-	2	295	c.296G>T	c.(295-297)tGc>tTc	p.C99F		NM_144663.1	NP_653264.1	Q8WZ69	CK040_HUMAN	chromosome 11 open reading frame 40	99										large_intestine(3)|lung(1)|ovary(2)|stomach(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TACCCTAAAGCAAGGTCTTTT	0.488000													22	60					5.35356e-11	8.90381e-11	0.002780	1	0
CACNA1S	779	broad.mit.edu	37	1	201028356	201028356	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:201028356G>T	ENST00000362061.3	-	27	3712	c.3486C>A	c.(3484-3486)acC>acA	p.T1162T	CACNA1S_ENST00000367338.3_Silent_p.T1162T	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1162					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCATCTCCAGGGTGAAGATGA	0.582000													27	40					1.17739e-12	2.0824e-12	0.005443	1	0
MYO7A	4647	broad.mit.edu	37	11	76892595	76892595	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:76892595G>T	ENST00000409709.3	+	23	3136	c.2864G>T	c.(2863-2865)gGc>gTc	p.G955V	MYO7A_ENST00000409893.1_Missense_Mutation_p.G955V|MYO7A_ENST00000409619.2_Missense_Mutation_p.G944V|MYO7A_ENST00000458637.2_Missense_Mutation_p.G955V	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	955			G -> S (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACTTCAGGTGGCCTGCCAGGC	0.602000													7	22					5.18039e-06	7.09684e-06	0.003080	1	0
PEG3	5178	broad.mit.edu	37	19	57326879	57326879	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:57326879G>T	ENST00000326441.9	-	10	3294	c.2931C>A	c.(2929-2931)tgC>tgA	p.C977*	PEG3_ENST00000593695.1_Nonsense_Mutation_p.C851*|PEG3_ENST00000598410.1_Nonsense_Mutation_p.C853*|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Nonsense_Mutation_p.C977*|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	977					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TATGAGCAAAGCACTCCCCAC	0.483000													12	92					2.27111e-07	3.38524e-07	0.001368	1	0
COLQ	8292	broad.mit.edu	37	3	15512054	15512054	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:15512054G>T	ENST00000383785.2	-	11	831	c.706C>A	c.(706-708)Cga>Aga	p.R236R	COLQ_ENST00000383788.5_Silent_p.R236R|COLQ_ENST00000603808.1_Silent_p.R236R|COLQ_ENST00000383787.2_Silent_p.R227R|COLQ_ENST00000383781.4_Silent_p.R226R|COLQ_ENST00000383786.5_Silent_p.R202R|COLQ_ENST00000435459.2_Silent_p.R226R			Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	236	Collagen-like 1.|Heparan sulfate proteoglycan binding (Potential).				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft				endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						TGCTTGCCTCGTTTTCCTGGT	0.552000													35	120					1.36161e-19	2.74641e-19	0.004289	1	0
NELL2	4753	broad.mit.edu	37	12	44915854	44915854	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:44915854G>T	ENST00000429094.2	-	18	2608	c.2104C>A	c.(2104-2106)Cat>Aat	p.H702N	NELL2_ENST00000549027.1_Missense_Mutation_p.H701N|NELL2_ENST00000333837.4_Missense_Mutation_p.H725N|NELL2_ENST00000437801.2_Missense_Mutation_p.H752N|NELL2_ENST00000395487.2_Missense_Mutation_p.H701N|NELL2_ENST00000452445.2_Missense_Mutation_p.H702N|NELL2_ENST00000551601.1_Missense_Mutation_p.H654N	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	702	VWFC 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CCATTTTGATGGAGGCACTGA	0.453000													7	28					1.26484e-09	2.05321e-09	0.003080	1	0
JMJD1C	221037	broad.mit.edu	37	10	64958312	64958312	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:64958312T>A	ENST00000399262.2	-	12	5670	c.5452A>T	c.(5452-5454)Aca>Tca	p.T1818S	JMJD1C_ENST00000402544.1_Missense_Mutation_p.T1599S|JMJD1C_ENST00000542921.1_Missense_Mutation_p.T1636S|JMJD1C_ENST00000399251.1_3'UTR	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1818					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTTCAGATGTTACTAATTGA	0.299000													42	74					0	0	0.002522	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450147	105450147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:105450147C>A	ENST00000337685.2	+	5	1507	c.722C>A	c.(721-723)tCa>tAa	p.S241*	MUM1L1_ENST00000372552.1_Nonsense_Mutation_p.S241*|MUM1L1_ENST00000357175.2_Nonsense_Mutation_p.S241*	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	241										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCACCTTTGTCACCTTTGTCA	0.428000													8	21					5.18039e-06	7.09684e-06	0.003080	1	0
OR2T4	127074	broad.mit.edu	37	1	248524987	248524987	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:248524987G>T	ENST00000366475.1	+	1	105	c.105G>T	c.(103-105)atG>atT	p.M35I		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCACCTGGATGGCCAACCACA	0.478000													32	51					4.74835e-14	8.65662e-14	0.002096	1	0
GPR50	9248	broad.mit.edu	37	X	150348412	150348412	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:150348412C>A	ENST00000218316.3	+	2	426	c.357C>A	c.(355-357)atC>atA	p.I119I		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	119					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTCAACATCGTGGCAATCG	0.542000													47	83					3.4345e-17	6.6447e-17	0.002852	1	0
ZNF713	349075	broad.mit.edu	37	7	55990971	55990971	+	Silent	SNP	A	A	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:55990971A>C	ENST00000429591.2	+	2	203	c.165A>C	c.(163-165)ctA>ctC	p.L55L	MRPS17_ENST00000426595.1_Silent_p.L55L|ZNF713_ENST00000482436.1_3'UTR	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACAGGAATCTAGTTGCACTGG	0.502000													15	74					0	0	0.004990	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436211	72436211	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:72436211G>T	ENST00000392627.1	+	2	1557	c.431G>T	c.(430-432)gGc>gTc	p.G144V	GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Missense_Mutation_p.G111V|GPRC5C_ENST00000342648.5_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	99						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GGGACCCTGGGCCTCTTCTGC	0.597000													33	70					3.11337e-16	5.95056e-16	0.002836	1	0
SLC30A8	169026	broad.mit.edu	37	8	118165318	118165318	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:118165318G>T	ENST00000427715.2	+	6	694	c.260G>T	c.(259-261)tGg>tTg	p.W87L	SLC30A8_ENST00000521243.1_Missense_Mutation_p.W87L|SLC30A8_ENST00000456015.2_Missense_Mutation_p.W136L|SLC30A8_ENST00000519688.1_Missense_Mutation_p.W87L	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	136					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			ACATTTGGATGGCACCGAGCA	0.512000													4	34					2.56e-06	3.59006e-06	0.000248	1	0
OPRL1	4987	broad.mit.edu	37	20	62729200	62729200	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr20:62729200G>T	ENST00000349451.3	+	5	691	c.279G>T	c.(277-279)ctG>ctT	p.L93L	OPRL1_ENST00000336866.2_Silent_p.L93L|OPRL1_ENST00000355631.4_Silent_p.L93L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	93					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TCTTTAACCTGGCCCTGGCCG	0.572000													47	94					4.0306e-16	7.64201e-16	0.003610	1	0
ANK3	288	broad.mit.edu	37	10	61830089	61830089	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:61830089T>A	ENST00000280772.1	-	37	10741	c.10550A>T	c.(10549-10551)gAt>gTt	p.D3517V	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3517					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.D3517V(1)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GAAGTAAGTATCAGGAAACAC	0.423000													19	48					0	0	0.008871	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436210	72436210	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:72436210G>T	ENST00000392627.1	+	2	1556	c.430G>T	c.(430-432)Ggc>Tgc	p.G144C	GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Missense_Mutation_p.G111C|GPRC5C_ENST00000342648.5_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	99						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						GGGGACCCTGGGCCTCTTCTG	0.597000													33	69					2.42023e-17	4.7016e-17	0.003271	1	0
OR5H6	79295	broad.mit.edu	37	3	97984019	97984019	+	Silent	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:97984019A>T	ENST00000383696.2	+	1	932	c.891A>T	c.(889-891)atA>atT	p.I297I	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ACACTGTCATAGTTCCTTTAT	0.378000													21	30					0	0	0.004656	0	0
CPNE7	27132	broad.mit.edu	37	16	89645307	89645307	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr16:89645307G>T	ENST00000268720.5	+	3	530	c.400G>T	c.(400-402)Gtt>Ttt	p.V134F	CPNE7_ENST00000319518.8_Intron	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	134					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GAGAGTGTCTGTTGATGTGCT	0.557000													12	19					6.40141e-05	8.59566e-05	0.000978	1	0
BTG4	54766	broad.mit.edu	37	11	111368781	111368781	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:111368781G>T	ENST00000525791.1	-	3	437	c.253C>A	c.(253-255)Cac>Aac	p.H85N	BTG4_ENST00000356018.2_Missense_Mutation_p.H85N			Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	85					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		AGTCCCAGGTGAGAAAAATCT	0.403000													20	29					2.4624e-09	3.9167e-09	0.008871	1	0
AFF2	2334	broad.mit.edu	37	X	147733577	147733577	+	Silent	SNP	A	A	G	rs144497911	byFrequency	TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:147733577A>G	ENST00000370460.2	+	2	584	c.105A>G	c.(103-105)caA>caG	p.Q35Q	AFF2_ENST00000370457.5_Silent_p.Q35Q|AFF2_ENST00000342251.3_Silent_p.Q35Q|AFF2_ENST00000370458.1_Silent_p.Q35Q	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	35					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGGAATCAAGAAGTCCAGC	0.363000													28	87					0	0	0.008361	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256753	69256753	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:69256753G>A	ENST00000439696.2	-	2	815	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	ZFP36L1_ENST00000336440.3_Missense_Mutation_p.R172C|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	172					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R172C(1)		breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AAGTGGCAGCGGGGCCCGTAG	0.667000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	74					0	0	0.003163	0	0
ZNF551	90233	broad.mit.edu	37	19	58199379	58199379	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:58199379G>C	ENST00000282296.5	+	3	1921	c.1736G>C	c.(1735-1737)aGa>aCa	p.R579T	ZNF551_ENST00000356715.4_Missense_Mutation_p.R563T|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron	NM_001270938.1	NP_001257867.1	Q7Z340	ZN551_HUMAN	zinc finger protein 551	579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAACACCAGAGAGTTCACACT	0.453000													8	78					0	0	0.003080	0	0
ACAP2	23527	broad.mit.edu	37	3	195022774	195022774	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:195022774C>A	ENST00000326793.6	-	14	1476	c.1246G>T	c.(1246-1248)Gac>Tac	p.D416Y		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	416	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						AGGCCACAGTCACAACAGCTG	0.542000													36	91					2.51541e-25	5.29913e-25	0.004878	1	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76877814	76877814	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:76877814C>A	ENST00000328299.3	+	3	483	c.335C>A	c.(334-336)aCc>aAc	p.T112N	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	112					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						AATGCCCCCACCAAAGGTTAT	0.453000													24	47					1.04121e-07	1.5972e-07	0.005443	1	0
OR5D14	219436	broad.mit.edu	37	11	55563554	55563554	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:55563554G>C	ENST00000335605.1	+	1	523	c.523G>C	c.(523-525)Gta>Cta	p.V175L		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TGGACCTAATGTAATCAACCA	0.498000													28	134					0	0	0.002096	0	0
RASSF8	11228	broad.mit.edu	37	12	26218312	26218312	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:26218312C>T	ENST00000405154.2	+	3	1184	c.985C>T	c.(985-987)Cgc>Tgc	p.R329C	RASSF8_ENST00000381352.3_Missense_Mutation_p.R329C|RASSF8_ENST00000282884.9_Missense_Mutation_p.R329C|RASSF8_ENST00000542865.1_Missense_Mutation_p.R329C|RASSF8_ENST00000541490.1_Missense_Mutation_p.R329C	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	329					signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					AGCCACCAAACGCTTACAGGT	0.408000													21	54					0	0	0.002299	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	10					0	0	0.004672	0	0
IGLON5	402665	broad.mit.edu	37	19	51826946	51826946	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:51826946G>T	ENST00000270642.8	+	3	189	c.189G>T	c.(187-189)gtG>gtT	p.V63V		NM_001101372.1	NP_001094842.1	A6NGN9	IGLO5_HUMAN	IgLON family member 5	63	Ig-like C2-type 1.					extracellular region				large_intestine(5)|lung(6)|prostate(1)	12						TGACCCGCGTGGCCTGGCTGA	0.642000													7	27					8.12818e-05	0.000108224	0.001984	1	0
SLC14A2	8170	broad.mit.edu	37	18	43204731	43204731	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:43204731C>T	ENST00000255226.6	+	2	918	c.102C>T	c.(100-102)tcC>tcT	p.S34S	SLC14A2_ENST00000586448.1_Silent_p.S34S	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	34						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTCGACATCCCCGGATACTC	0.572000													13	34					0	0	0.002450	0	0
SYT7	9066	broad.mit.edu	37	11	61291321	61291321	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:61291321G>A	ENST00000263846.4	-	7	1212	c.885C>T	c.(883-885)gcC>gcT	p.A295A	SYT7_ENST00000542836.1_Silent_p.A339A|SYT7_ENST00000542670.1_Silent_p.A503A|SYT7_ENST00000540677.1_Silent_p.A370A|SYT7_ENST00000539008.1_Silent_p.A578A|SYT7_ENST00000535826.1_Silent_p.A414A	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	295	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CGATGTCCATGGCTTTGAGGT	0.607000													119	185					0	0	0.003610	0	0
AFF4	27125	broad.mit.edu	37	5	132228047	132228047	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:132228047C>A	ENST00000265343.5	-	13	2825	c.2446G>T	c.(2446-2448)Gct>Tct	p.A816S	AFF4_ENST00000378595.3_Missense_Mutation_p.A816S	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	816					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGGCCCAGCGGGAGAAGGC	0.448000													26	83					9.86323e-18	1.94799e-17	0.003954	1	0
NKAP	79576	broad.mit.edu	37	X	119059199	119059199	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:119059199C>A	ENST00000371410.3	-	9	1398	c.1232G>T	c.(1231-1233)gGg>gTg	p.G411V	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	411	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						GTCATCCTTCCCTTTGGTCTT	0.368000													20	94					4.35082e-09	6.89728e-09	0.001523	1	0
PCDHB16	57717	broad.mit.edu	37	5	140562299	140562299	+	Silent	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr5:140562299G>A	ENST00000361016.2	+	1	1320	c.165G>A	c.(163-165)ggG>ggA	p.G55G		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		55	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGGGTTGGGGTTGACAGAGA	0.532000													42	47					0	0	0.008740	0	0
FBXL4	26235	broad.mit.edu	37	6	99374671	99374671	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:99374671T>A	ENST00000369244.2	-	4	622	c.194A>T	c.(193-195)tAt>tTt	p.Y65F	FBXL4_ENST00000229971.1_Missense_Mutation_p.Y65F			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	65					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		CTCACTTCCATAATGGGAACT	0.423000													29	71					0	0	0.002096	0	0
CHRM2	1129	broad.mit.edu	37	7	136699633	136699633	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr7:136699633C>A	ENST00000445907.2	+	3	549	c.21C>A	c.(19-21)tcC>tcA	p.S7S	AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000401861.1_Silent_p.S7S|CHRM2_ENST00000453373.1_Silent_p.S7S|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000320658.5_Silent_p.S7S|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000397608.3_Silent_p.S7S|CHRM2_ENST00000402486.3_Silent_p.S7S	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	7					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAACAAACTCCTCTAACAATA	0.368000													17	28					3.32936e-07	4.90098e-07	0.006122	1	0
SNHG12	85028	broad.mit.edu	37	1	28905316	28905316	+	RNA	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:28905316G>A	ENST00000488745.1	-	0	1225				SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNORD99_ENST00000408612.1_RNA																							ACTCAAATTAGGTTTCATCCT	0.473000													44	91					0	0	0.002522	0	0
TRPM1	4308	broad.mit.edu	37	15	31324973	31324973	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:31324973G>T	ENST00000542188.1	-	21	3235	c.2922C>A	c.(2920-2922)atC>atA	p.I974I	TRPM1_ENST00000256552.6_Silent_p.I957I|RP11-348B17.1_ENST00000561299.1_RNA|RP11-348B17.1_ENST00000558755.1_RNA|TRPM1_ENST00000397795.2_Silent_p.I935I	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	935					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACCAGAAGATGATATCCACAC	0.483000													26	53					4.43304e-23	9.21605e-23	0.006320	1	0
PRPS2	5634	broad.mit.edu	37	X	12838875	12838875	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:12838875A>G	ENST00000380668.5	+	6	945	c.817A>G	c.(817-819)Aac>Gac	p.N273D	PRPS2_ENST00000398491.2_Missense_Mutation_p.N276D	NM_001039091.2|NM_002765.4	NP_001034180.1|NP_002756.1	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	273					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TGTCGTCACAAACACAATTCC	0.468000													29	41					0	0	0.008361	0	0
PAXBP1	94104	broad.mit.edu	37	21	34123457	34123457	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr21:34123457C>A	ENST00000331923.4	-	9	1769	c.1580G>T	c.(1579-1581)cGt>cTt	p.R527L	PAXBP1_ENST00000290178.4_Missense_Mutation_p.R527L	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TGCAATGCGACGTTTTGCATG	0.463000													10	41					0.00829132	0.00997483	0.008291	1	0
TRPS1	7227	broad.mit.edu	37	8	116631944	116631944	+	Silent	SNP	T	T	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:116631944T>C	ENST00000395715.3	-	3	958	c.381A>G	c.(379-381)tcA>tcG	p.S127S	TRPS1_ENST00000519076.1_Intron|TRPS1_ENST00000519674.1_Silent_p.S114S|TRPS1_ENST00000520276.1_Silent_p.S118S|TRPS1_ENST00000220888.5_Silent_p.S114S	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	114					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CAGCTGGAGATGAGAAAGCCA	0.532000									Langer-Giedion syndrome				17	84					0	0	0.004990	0	0
CDH19	28513	broad.mit.edu	37	18	64211367	64211367	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr18:64211367G>A	ENST00000262150.2	-	7	1347	c.1055C>T	c.(1054-1056)gCt>gTt	p.A352V	CDH19_ENST00000540086.1_Missense_Mutation_p.A352V	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	352	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				AGTGGTGGAAGCCTCAGTGTG	0.418000													5	28					0	0	0.000602	0	0
AFF2	2334	broad.mit.edu	37	X	147743554	147743554	+	Silent	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:147743554G>T	ENST00000370460.2	+	3	785	c.306G>T	c.(304-306)gtG>gtT	p.V102V	AFF2_ENST00000370457.5_Silent_p.V98V|AFF2_ENST00000342251.3_Silent_p.V98V|AFF2_ENST00000370458.1_Silent_p.V98V	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	102					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AGAATTCTGTGCCCCAGAATC	0.398000													82	117					8.00303e-49	1.74813e-48	0.003610	1	0
PIGS	94005	broad.mit.edu	37	17	26881313	26881313	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:26881313C>T	ENST00000308360.7	-	12	1968	c.1593G>A	c.(1591-1593)gtG>gtA	p.V531V	PIGS_ENST00000543734.1_Silent_p.V470V|PIGS_ENST00000395346.2_Silent_p.V523V	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	531					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					GGAGGATGGGCACAGCCATAG	0.547000													24	39					0	0	0.005443	0	0
BEST3	144453	broad.mit.edu	37	12	70049315	70049315	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:70049315G>T	ENST00000330891.5	-	10	1605	c.1379C>A	c.(1378-1380)cCc>cAc	p.P460H	BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Missense_Mutation_p.P354H|BEST3_ENST00000488961.1_Missense_Mutation_p.P247H	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	460						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GTGCAGCGTGGGGCTTCCTTC	0.592000													18	44					5.03518e-11	8.40379e-11	0.007413	1	0
PLSCR2	57047	broad.mit.edu	37	3	146177780	146177780	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:146177780C>T	ENST00000497985.1	-	4	570	c.131G>A	c.(130-132)gGa>gAa	p.G44E	PLSCR2_ENST00000336685.2_5'UTR	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	0					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						ATGCTGACGTCCTGGGTAGAA	0.567000													6	9					0	0	0.001168	0	0
CCL14	6358	broad.mit.edu	37	17	34313569	34313569	+	Translation_Start_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:34313569G>T	ENST00000480944.2	-	0	471				CCL15-CCL14_ENST00000481427.2_Intron|CCL14_ENST00000394509.4_Intron|CTB-186H2.3_ENST00000593057.1_Intron|CCL14_ENST00000435911.2_Intron|CCL14_ENST00000536149.1_Intron|CTB-186H2.3_ENST00000591669.1_Splice_Site|CCL14_ENST00000586216.1_Intron			Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14						cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|lung(6)	7		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTTCCCTGCAGGCTCTAGGTT	0.532000													8	23					0.000157383	0.000206647	0.003080	1	0
PCDH18	54510	broad.mit.edu	37	4	138442189	138442189	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:138442189C>A	ENST00000344876.4	-	4	3788	c.3402G>T	c.(3400-3402)caG>caT	p.Q1134H	PCDH18_ENST00000510305.1_Missense_Mutation_p.Q345H|PCDH18_ENST00000507846.1_Missense_Mutation_p.Q913H|PCDH18_ENST00000511115.1_Missense_Mutation_p.Q314H|PCDH18_ENST00000412923.2_Missense_Mutation_p.Q1133H	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1134	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCTCCTAGCTCTGGCGGACAT	0.418000													16	44					2.32078e-09	3.71639e-09	0.003163	1	0
SLC4A4	8671	broad.mit.edu	37	4	72400105	72400105	+	Splice_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:72400105G>T	ENST00000340595.3	+	15	2506	c.2310_splice	c.e15+1	p.K770_splice	SLC4A4_ENST00000264485.5_Splice_Site_p.K814_splice|SLC4A4_ENST00000425175.1_Splice_Site_p.K814_splice|SLC4A4_ENST00000351898.6_Splice_Site_p.K814_splice	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	814	Interaction with CA4.					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ATAAACTCAAGGTAAGTGTCC	0.378000													10	25					0.00829132	0.00997483	0.008291	1	0
TNR	7143	broad.mit.edu	37	1	175355258	175355258	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:175355258C>G	ENST00000367674.1	-	8	2395	c.1687G>C	c.(1687-1689)Gcc>Ccc	p.A563P	TNR_ENST00000263525.2_Missense_Mutation_p.A563P	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	563	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GGCCGCAGGGCCTGCACTGAG	0.592000													34	66					0	0	0.002096	0	0
PLCE1	51196	broad.mit.edu	37	10	96068457	96068457	+	Splice_Site	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:96068457G>T	ENST00000260766.3	+	27	6637		c.e27+1		PLCE1_ENST00000371375.1_Splice_Site|PLCE1_ENST00000371385.3_Splice_Site|PLCE1_ENST00000371380.2_Splice_Site	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1						activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGCCTCTTCGGTAATGAAGTT	0.408000													20	64					3.8784e-16	7.38299e-16	0.001882	1	0
DISP2	85455	broad.mit.edu	37	15	40657403	40657403	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:40657403G>A	ENST00000267889.3	+	6	862	c.775G>A	c.(775-777)Gct>Act	p.A259T		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	259					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCAGGAGAGCGCTGTCCGGCC	0.597000													13	68					0	0	0.001368	0	0
NRXN1	9378	broad.mit.edu	37	2	50724812	50724812	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:50724812G>T	ENST00000404971.1	-	15	3997	c.2658C>A	c.(2656-2658)aaC>aaA	p.N886K	NRXN1_ENST00000401669.2_Missense_Mutation_p.N846K|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000405472.3_Missense_Mutation_p.N838K|NRXN1_ENST00000402717.3_Missense_Mutation_p.N838K|NRXN1_ENST00000406859.3_Missense_Mutation_p.N846K|NRXN1_ENST00000406316.2_Missense_Mutation_p.N846K	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	846	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGTCTCTATGTTATGGAACT	0.403000													26	50					4.43304e-23	9.21605e-23	0.006320	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074470	76074470	+	RNA	SNP	A	A	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr15:76074470A>G	ENST00000395215.3	+	0	649																		p.Q203R(4)									CGGTTACAGCAGACCATAAAG	0.577000													6	35					0	0	0.008291	0	0
ACVR1C	130399	broad.mit.edu	37	2	158406824	158406824	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:158406824C>T	ENST00000243349.7	-	4	985	c.625G>A	c.(625-627)Gtg>Atg	p.V209M	ACVR1C_ENST00000348328.5_Intron|ACVR1C_ENST00000335450.7_Missense_Mutation_p.V129M|ACVR1C_ENST00000409680.3_Missense_Mutation_p.V159M	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	209	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						CCATGCCACACCTCACCAAAT	0.438000													19	117					0	0	0.007413	0	0
FHL1	2273	broad.mit.edu	37	X	135291445	135291445	+	Silent	SNP	T	T	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chrX:135291445T>A	ENST00000394155.2	+	7	1061	c.732T>A	c.(730-732)gcT>gcA	p.A244A	FHL1_ENST00000535737.1_Intron|FHL1_ENST00000394153.2_Intron|FHL1_ENST00000370690.3_Intron|FHL1_ENST00000370676.3_Intron|FHL1_ENST00000539015.1_Intron|FHL1_ENST00000345434.3_Silent_p.A244A|FHL1_ENST00000543669.1_Intron|FHL1_ENST00000370683.1_Intron	NM_001159702.2	NP_001153174.1	Q13642	FHL1_HUMAN	four and a half LIM domains 1	244					cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(192;0.000127)					TCTCTAAAGCTAGGAAGCCCC	0.572000											OREG0019943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	38					0	0	0.000602	0	0
TAS2R30	259293	broad.mit.edu	37	12	11286256	11286256	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:11286256C>A	ENST00000539585.1	-	1	987	c.588G>T	c.(586-588)ctG>ctT	p.L196L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						AGATTAACAGCAGAAAAGATA	0.418000													57	183					3.89483e-19	7.82266e-19	0.003610	1	0
NRROS	375387	broad.mit.edu	37	3	196387130	196387130	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:196387130G>C	ENST00000328557.4	+	3	819	c.616G>C	c.(616-618)Gag>Cag	p.E206Q		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		CGGCCTGGCTGAGCTGAGGCA	0.632000													14	26					0	0	0.003163	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883255	228883255	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:228883255G>A	ENST00000392056.3	-	7	2361	c.2315C>T	c.(2314-2316)tCt>tTt	p.S772F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S772F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	772						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTAAGTGGAGAGCTGCTGGA	0.502000													25	91					0	0	0.004656	0	0
TRAPPC9	83696	broad.mit.edu	37	8	140743352	140743352	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:140743352C>G	ENST00000389328.4	-	23	3707	c.3693G>C	c.(3691-3693)tgG>tgC	p.W1231C	TRAPPC9_ENST00000389327.3_Missense_Mutation_p.W1124C|TRAPPC9_ENST00000522504.1_5'UTR|TRAPPC9_ENST00000438773.2_Missense_Mutation_p.W1133C	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	1133					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GCAGGCAGAACCAAGAGGGTG	0.657000													12	48					0	0	0.001855	0	0
SOWAHB	345079	broad.mit.edu	37	4	77816994	77816994	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:77816994C>A	ENST00000334306.2	-	1	2008	c.2009G>T	c.(2008-2010)gGa>gTa	p.G670V		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	670																	CGGGGTATATCCACAACTGGA	0.532000													30	172					9.65021e-13	1.71962e-12	0.002096	1	0
PCBP2	5094	broad.mit.edu	37	12	53853102	53853102	+	Missense_Mutation	SNP	C	C	T	rs111807426		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr12:53853102C>T	ENST00000603815.1	+	6	640	c.290C>T	c.(289-291)cCg>cTg	p.P97L	PCBP2_ENST00000546463.1_Missense_Mutation_p.P97L|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000541275.1_Missense_Mutation_p.P97L|PCBP2_ENST00000549863.1_Missense_Mutation_p.P97L|PCBP2_ENST00000548933.1_Missense_Mutation_p.P97L|PCBP2_ENST00000359462.5_Missense_Mutation_p.P97L|PCBP2_ENST00000359282.5_Missense_Mutation_p.P97L|PCBP2_ENST00000439930.3_Missense_Mutation_p.P97L|PCBP2_ENST00000552819.1_Missense_Mutation_p.P97L|PCBP2_ENST00000552296.2_Missense_Mutation_p.P97L|PCBP2_ENST00000455667.3_Missense_Mutation_p.P97L|PCBP2_ENST00000447282.1_Missense_Mutation_p.P97L|PCBP2_ENST00000437231.1_Missense_Mutation_p.P97L	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	97	KH 2.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding	p.P97L(2)		central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						AGTAGACCCCCGGTCACCCTG	0.488000													23	63					0	0	0.003330	0	0
NWD1	284434	broad.mit.edu	37	19	16890214	16890214	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:16890214G>A	ENST00000524140.2	+	12	3087	c.2669G>A	c.(2668-2670)gGc>gAc	p.G890D	NWD1_ENST00000339803.6_Missense_Mutation_p.G755D|NWD1_ENST00000552788.1_Missense_Mutation_p.G890D|NWD1_ENST00000549814.1_Missense_Mutation_p.G890D|NWD1_ENST00000523826.1_Missense_Mutation_p.G684D|NWD1_ENST00000379808.3_Missense_Mutation_p.G890D	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	890							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ACCCAGGATGGCATCATGGCT	0.552000											OREG0025337	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	58					0	0	0.003271	0	0
BMP5	653	broad.mit.edu	37	6	55623883	55623883	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:55623883C>A	ENST00000370830.3	-	6	1833	c.1135G>T	c.(1135-1137)Gca>Tca	p.A379S	BMP5_ENST00000446683.2_Intron	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	379					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAATAAAATGCAGCGTATCCT	0.348000													18	36					0.00498961	0.00606429	0.004990	1	0
MYH1	4619	broad.mit.edu	37	17	10401191	10401191	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:10401191C>A	ENST00000226207.5	-	31	4319	c.4225G>T	c.(4225-4227)Gaa>Taa	p.E1409*	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1409						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTCACAGCTTCTACATGTTCC	0.458000													8	37					0.000157383	0.000206647	0.003080	1	0
ADCY8	114	broad.mit.edu	37	8	131922105	131922105	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:131922105G>C	ENST00000286355.5	-	6	3581	c.1489C>G	c.(1489-1491)Cgg>Ggg	p.R497G	ADCY8_ENST00000377928.3_Missense_Mutation_p.R497G	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	497					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTCCTTGACCGCACATACCTG	0.448000										HNSCC(32;0.087)			65	40					0	0	0.003610	0	0
CTTN	2017	broad.mit.edu	37	11	70282409	70282409	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:70282409G>T	ENST00000376561.3	+	19	1971	c.1800G>T	c.(1798-1800)agG>agT	p.R600S	CTTN_ENST00000346329.3_3'UTR|CTTN_ENST00000301843.8_3'UTR	NM_001184740.1	NP_001171669.1	Q14247	SRC8_HUMAN	cortactin	0						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CCTTCCTGAGGAGCCGGGAGG	0.602000													26	72					7.92952e-12	1.38184e-11	0.003954	1	0
LTBP1	4052	broad.mit.edu	37	2	33498809	33498809	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr2:33498809G>A	ENST00000404816.2	+	16	3057	c.2704G>A	c.(2704-2706)Gag>Aag	p.E902K	LTBP1_ENST00000402934.1_Missense_Mutation_p.E523K|LTBP1_ENST00000407925.1_Missense_Mutation_p.E576K|LTBP1_ENST00000354476.3_Missense_Mutation_p.E903K|LTBP1_ENST00000390003.4_Missense_Mutation_p.E577K|LTBP1_ENST00000418533.2_Missense_Mutation_p.E576K|LTBP1_ENST00000404525.1_Missense_Mutation_p.E523K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	902	EGF-like 4; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TATATGCTACGAGGGCTACAG	0.348000													8	14					0	0	0.004482	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1506627	1506627	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:1506627C>A	ENST00000330475.4	-	11	1519	c.1076G>T	c.(1075-1077)cGc>cTc	p.R359L	ADAMTSL5_ENST00000590562.1_5'UTR|ADAMTSL5_ENST00000395467.2_Intron|ADAMTSL5_ENST00000413997.2_Missense_Mutation_p.R369L	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	359	NTR.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGTGGGCGCGGCCGCGGGT	0.662000													21	8					2.39556e-15	4.48813e-15	0.002780	1	0
LPA	4018	broad.mit.edu	37	6	160953593	160953593	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr6:160953593C>A	ENST00000447678.1	-	39	6051	c.5931G>T	c.(5929-5931)gaG>gaT	p.E1977D	LPA_ENST00000316300.5_Missense_Mutation_p.E1977D|LPA_ENST00000484276.1_Intron	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4485	Kringle 18.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGCCAAATGCTCAGCACAAA	0.453000													15	32					1.05317e-09	1.72139e-09	0.002450	1	0
DOCK3	1795	broad.mit.edu	37	3	51251551	51251551	+	Splice_Site	SNP	A	A	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:51251551A>T	ENST00000266037.9	+	14	1149		c.e14-1			NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTGTTTTTGCAGGTCTTATCA	0.363000													5	15					0	0	0.001984	0	0
CEP128	145508	broad.mit.edu	37	14	81371171	81371171	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr14:81371171C>T	ENST00000555265.1	-	6	841	c.466G>A	c.(466-468)Gat>Aat	p.D156N	CEP128_ENST00000281129.3_Missense_Mutation_p.D156N|CEP128_ENST00000327841.2_Missense_Mutation_p.D96N|CEP128_ENST00000216517.6_Missense_Mutation_p.D156N			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	156						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						GTCATATCATCAGTCTCTTGA	0.393000													36	41					0	0	0.004878	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781777	128781777	+	Silent	SNP	C	C	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:128781777C>A	ENST00000529694.1	+	2	985	c.609C>A	c.(607-609)tcC>tcA	p.S203S	KCNJ5_ENST00000338350.4_Silent_p.S203S|KCNJ5_ENST00000533599.1_Silent_p.S203S	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	203					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TCATGTTTTCCAACAACGCAG	0.592000													7	65					8.12818e-05	0.000108224	0.001984	1	0
OR5M1	390168	broad.mit.edu	37	11	56380513	56380513	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:56380513C>T	ENST00000526538.1	-	1	465	c.466G>A	c.(466-468)Ggg>Agg	p.G156R		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						TGAGAGAACCCACTAAGAAAC	0.458000													12	41					0	0	0.000978	0	0
VPS13B	157680	broad.mit.edu	37	8	100866131	100866131	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr8:100866131G>T	ENST00000358544.2	+	56	10700	c.10589G>T	c.(10588-10590)cGg>cTg	p.R3530L	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.R3505L	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3530					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAACCTGCTCGGTTATACGTG	0.408000													32	115					2.85442e-18	5.66106e-18	0.002096	1	0
ATP7B	540	broad.mit.edu	37	13	52513211	52513211	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr13:52513211C>T	ENST00000242839.4	-	17	3831	c.3675G>A	c.(3673-3675)aaG>aaA	p.K1225K	ATP7B_ENST00000344297.5_Silent_p.K1018K|ATP7B_ENST00000417240.2_Silent_p.K436K|ATP7B_ENST00000418097.2_Silent_p.K1160K|ATP7B_ENST00000400370.3_Silent_p.K795K|ATP7B_ENST00000448424.2_Silent_p.K1147K|ATP7B_ENST00000400366.3_Silent_p.K1114K	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1225					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CTCTGGCTGTCTTCCGGTTGT	0.542000									Wilson disease				48	67					0	0	0.003610	0	0
HTR1F	3355	broad.mit.edu	37	3	88040472	88040472	+	Silent	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:88040472C>T	ENST00000319595.4	+	1	627	c.573C>T	c.(571-573)taC>taT	p.Y191Y		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	191					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GAGCTTTCTACATCCCACTGG	0.413000													13	24					0	0	0.001368	0	0
SLC10A6	345274	broad.mit.edu	37	4	87749282	87749282	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:87749282C>T	ENST00000273905.6	-	4	772	c.625G>A	c.(625-627)Gca>Aca	p.A209T	SLC10A6_ENST00000505535.1_Intron	NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	209						integral to membrane|plasma membrane	bile acid:sodium symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		CCAGCAACTGCGACCACCAGA	0.453000													7	46					0	0	0.006214	0	0
TMEM52	339456	broad.mit.edu	37	1	1850628	1850636	+	In_Frame_Del	DEL	AGCGGCAGG	AGCGGCAGG	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr1:1850628_1850636delAGCGGCAGG	ENST00000310991.3	-	1	76_84	c.69_77delCCTGCCGCT	c.(67-78)ctg>ct	p.LLPL23del		NM_178545.3	NP_848640.1	Q8NDY8	TMM52_HUMAN	transmembrane protein 52	23						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCTgcggcagcggcaggagcggcagga	0.766													4	5	---	---	---	---					
ALDH1L1	10840	broad.mit.edu	37	3	125836866	125836866	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr3:125836866delC	ENST00000393434.2	-	17	2313	c.1964delG	c.(1963-1965)gcfs	p.G655fs	ALDH1L1_ENST00000452905.2_Frame_Shift_Del_p.G554fs|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000273450.3_Frame_Shift_Del_p.G665fs|ALDH1L1_ENST00000472186.1_Frame_Shift_Del_p.G655fs	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	655	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GATGTGCTTGCCCACCTCTGT	0.632													18	30	---	---	---	---					
PCDH7	5099	broad.mit.edu	37	4	30921902	30921903	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr4:30921902_30921903insA	ENST00000543491.1	+	2	3302_3303	c.3302_3303insA	c.(3301-3303)cagfs	p.Q1101fs	PCDH7_ENST00000509925.1_3'UTR			O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						TCATCAGGGCCAAGACTGGGTG	0.554													11	43	---	---	---	---					
ITGA8	8516	broad.mit.edu	37	10	15713635	15713636	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:15713635_15713636insA	ENST00000378076.3	-	8	1166_1167	c.813_814insT	c.(811-816)gtctgcfs	p.C272fs		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	272					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TCCCCAGCAGCAACTGAGTATC	0.371													11	14	---	---	---	---					
BMS1	9790	broad.mit.edu	37	10	43316126	43316126	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:43316126delA	ENST00000374518.4	+	17	3003	c.2940delA	c.(2938-2940)gcfs	p.A981fs		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	981					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ATTGCGGAGCAGCCTTTTGGG	0.408													11	43	---	---	---	---					
PLCE1	51196	broad.mit.edu	37	10	96084675	96084675	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:96084675delC	ENST00000260766.3	+	32	7381	c.6747delC	c.(6745-6747)ggfs	p.G2249fs	PLCE1_ENST00000371385.3_Frame_Shift_Del_p.G1941fs|PLCE1_ENST00000371375.1_Frame_Shift_Del_p.G1941fs|PLCE1_ENST00000464214.1_3'UTR|NOC3L_ENST00000543788.1_Intron|PLCE1_ENST00000371380.2_Frame_Shift_Del_p.G2249fs	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	2249					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AAAAGAAAGGCATTTCTTTCG	0.428													26	39	---	---	---	---					
TUBGCP2	10844	broad.mit.edu	37	10	135093312	135093312	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr10:135093312delC	ENST00000368563.2	-	18	3023	c.2667delG	c.(2665-2667)ggfs	p.G889fs	TUBGCP2_ENST00000543663.1_Frame_Shift_Del_p.G917fs|TUBGCP2_ENST00000368562.1_Frame_Shift_Del_p.G482fs|TUBGCP2_ENST00000417178.2_Frame_Shift_Del_p.G759fs|TUBGCP2_ENST00000252936.3_Frame_Shift_Del_p.G889fs	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	889					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GAGCCGGGGGCCCCCGCAGGA	0.647													5	11	---	---	---	---					
ATM	472	broad.mit.edu	37	11	108115600	108115601	+	Frame_Shift_Del	DEL	CG	CG	-	rs56123940		TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:108115600_108115601delCG	ENST00000278616.4	+	7	1133_1134	c.748_749delCG	c.(748-750)afs	p.R250fs	ATM_ENST00000452508.2_Frame_Shift_Del_p.R250fs	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	250			R -> Q.		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R250*(4)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTTTCGAATTCGAGTGTGTGAA	0.337			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			20	63	---	---	---	---					
ATM	472	broad.mit.edu	37	11	108186559	108186559	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr11:108186559delT	ENST00000278616.4	+	41	6401	c.6016delT	c.(6016-6018)tafs	p.L2006fs	ATM_ENST00000452508.2_Frame_Shift_Del_p.L2006fs|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2006	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGATCTTCTCTTAGAAATCTA	0.323			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			13	33	---	---	---	---					
KRT19	3880	broad.mit.edu	37	17	39680687	39680688	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39680687_39680688insT	ENST00000361566.3	-	4	825_826	c.765_766insA	c.(763-768)caatgafs	p.*256fs		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				ATGACCTCATATTGGCTTCGCA	0.604													13	102	---	---	---	---					
LEPREL4	10609	broad.mit.edu	37	17	39964116	39964116	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr17:39964116delG	ENST00000355468.3	-	6	1523	c.1057delC	c.(1057-1059)ggfs	p.R353fs	LEPREL4_ENST00000393928.1_Frame_Shift_Del_p.R353fs			Q92791	SC65_HUMAN	leprecan-like 4	353	Asp/Glu-rich (acidic).				synaptonemal complex assembly	nucleolus|synaptonemal complex	binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						CCCACCTCCCGGGGCTGGAAG	0.602													18	31	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1221254	1221254	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr19:1221254delC	ENST00000326873.7	+	6	1950	c.777delC	c.(775-777)aafs	p.N259fs		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	259	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.Y246fs*3(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGGGACAACATCTACAAGT	0.582		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			22	8	---	---	---	---					
NCAM2	4685	broad.mit.edu	37	21	22658718	22658718	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr21:22658718delC	ENST00000400546.1	+	4	716	c.467delC	c.(466-468)acfs	p.T157fs	NCAM2_ENST00000284894.7_Intron|NCAM2_ENST00000486367.1_3'UTR|NCAM2_ENST00000535285.1_Frame_Shift_Del_p.T182fs	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	157	Ig-like C2-type 2.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GAGGAAGTCACCACTATTTCC	0.383													8	47	---	---	---	---					
SBF1	6305	broad.mit.edu	37	22	50894982	50894982	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7159-01A-11D-2036-08	TCGA-78-7159-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9319083d-b3d1-48e5-b97f-71b162f9dc7c	c0161396-4ff4-460a-bb15-d3d3520b9194	g.chr22:50894982delG	ENST00000380817.2	-	30	4208	c.4025delC	c.(4024-4026)cgfs	p.P1342fs	SBF1_ENST00000348911.6_Frame_Shift_Del_p.P1317fs|SBF1_ENST00000390679.3_Frame_Shift_Del_p.P1316fs	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1316	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGAAGCCCGGGTCGGGAGG	0.711													2	4	---	---	---	---					
