Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLAA	9373	broad.mit.edu	37	9	26926558	26926558	+	Splice_Site	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:26926558C>A	ENST00000397292.3	-	5	983	c.565_splice	c.e5-1	p.G189_splice	PLAA_ENST00000520884.1_Splice_Site_p.G189_splice	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	189					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GTCTTCATGCCCTGCATTAAA	0.338000													8	50					1.06961e-07	1.26134e-07	1	1	0
FRAS1	80144	broad.mit.edu	37	4	79460483	79460483	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:79460483C>T	ENST00000264895.6	+	73	11774	c.11334C>T	c.(11332-11334)ttC>ttT	p.F3778F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3773					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ATAAGTACTTCCATGATGTGC	0.423000													4	105					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369339.2_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													4	93					0	0	1	0	0
KPNA1	3836	broad.mit.edu	37	3	122168504	122168504	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:122168504G>A	ENST00000344337.6	-	9	1010	c.834C>T	c.(832-834)ctC>ctT	p.L278L	KPNA1_ENST00000466923.1_5'UTR	NM_002264.3	NP_002255.3	P52294	IMA1_HUMAN	karyopherin alpha 1 (importin alpha 5)	278	Binding to RAG1.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity			NS(1)|breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	21				GBM - Glioblastoma multiforme(114;0.0898)		ATAGATATGAGAGGGCCCAGC	0.438000													4	60					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243727072	243727072	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:243727072C>T	ENST00000366539.1	-	10	1098	c.898G>A	c.(898-900)Gca>Aca	p.A300T	AKT3_ENST00000263826.5_Missense_Mutation_p.A300T|AKT3_ENST00000336199.5_Missense_Mutation_p.A300T|AKT3_ENST00000366540.1_Missense_Mutation_p.A300T			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	300	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			ATGGTGGCTGCATCTGTGATC	0.398000													5	88					0	0	1	0	0
MORC4	79710	broad.mit.edu	37	X	106198242	106198242	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:106198242C>T	ENST00000355610.4	-	14	1860	c.1586G>A	c.(1585-1587)gGa>gAa	p.G529E	MORC4_ENST00000255495.7_Missense_Mutation_p.G529E|MORC4_ENST00000535534.1_Missense_Mutation_p.G277E	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	529							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						GCTATGAATTCCCTCATATCC	0.393000													26	63					0	0	1	0	0
IGKV2D-29	28882	broad.mit.edu	37	2	89986381	89986381	+	RNA	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:89986381G>T	ENST00000491977.1	+	0	60																											TCCTGGGGCTGCTAATGCTCT	0.542000													11	80					6.72482e-11	8.49094e-11	1	1	0
PTPRC	5788	broad.mit.edu	37	1	198666011	198666011	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:198666011G>C	ENST00000367376.2	+	4	436	c.265G>C	c.(265-267)Gat>Cat	p.D89H	PTPRC_ENST00000391970.3_Intron|PTPRC_ENST00000594404.1_Intron|PTPRC_ENST00000352140.3_Missense_Mutation_p.D89H|PTPRC_ENST00000348564.6_Intron|PTPRC_ENST00000442510.2_Missense_Mutation_p.D91H	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	89					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GGACTCTTTGGATAATGCTAG	0.398000													24	192					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104512727	104512727	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:104512727G>A	ENST00000304883.2	-	4	1142	c.1002C>T	c.(1000-1002)atC>atT	p.I334I	RP11-297P16.3_ENST00000512401.1_RNA|RP11-297P16.3_ENST00000502936.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	334						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGACCTGCTGGATGTATTTCC	0.393000													17	75					0	0	1	0	0
OR5K2	402135	broad.mit.edu	37	3	98217213	98217213	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:98217213C>A	ENST00000427338.1	+	1	766	c.689C>A	c.(688-690)tCc>tAc	p.S230Y	CLDND1_ENST00000502288.1_Intron	NM_001004737.1	NP_001004737.1	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						AGAATGAAATCCAAGGAGGGA	0.343000													9	100					0.000442599	0.000468855	1	1	0
BLZF1	8548	broad.mit.edu	37	1	169356302	169356302	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:169356302C>T	ENST00000367808.3	+	7	1508	c.1085C>T	c.(1084-1086)tCa>tTa	p.S362L	BLZF1_ENST00000329281.2_Missense_Mutation_p.S362L			Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	362					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	14	all_hematologic(923;0.208)					TTTGAGTCTTCACCAACCACC	0.348000													5	94					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57734101	57734101	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:57734101C>T	ENST00000360716.3	+	5	644	c.423C>T	c.(421-423)ccC>ccT	p.P141P	RP11-405F3.4_ENST00000563062.1_RNA|CCDC135_ENST00000394337.4_Silent_p.P141P|CCDC135_ENST00000336825.8_Silent_p.P141P			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	141						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						TGCCCTACCCCGAGCTCTACA	0.577000													12	162					0	0	1	0	0
UBXN4	23190	broad.mit.edu	37	2	136537772	136537772	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:136537772C>T	ENST00000272638.9	+	12	1516	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	402					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						CCAACTGCATCCATTGTACAC	0.398000													9	118					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	979091	979091	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:979091G>T	ENST00000379370.2	+	9	1827	c.1777G>T	c.(1777-1779)Gtg>Ttg	p.V593L		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	593	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CAGCCTGCACGTGGCCTCAGC	0.706000													5	57					8.12818e-05	8.75882e-05	1	1	0
GPR179	440435	broad.mit.edu	37	17	36499178	36499178	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:36499178C>T	ENST00000342292.4	-	1	515	c.495G>A	c.(493-495)caG>caA	p.Q165Q		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	165						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCCGGGTGGCCTGCAGGGCCA	0.647000													8	65					0	0	1	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056803	24056803	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:24056803G>C	ENST00000238789.5	-	14	2057	c.1714C>G	c.(1714-1716)Ctg>Gtg	p.L572V		NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	572							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCAGGCAGGTTGAAGAGG	0.353000													5	36					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70818760	70818760	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:70818760C>T	ENST00000358731.4	+	24	5634	c.5371C>T	c.(5371-5373)Ctc>Ttc	p.L1791F	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1791					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGAGCAATATCTCAATAAACT	0.303000													3	47					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64136374	64136374	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr10:64136374G>A	ENST00000395254.3	+	2	702	c.422G>A	c.(421-423)gGg>gAg	p.G141E	ZNF365_ENST00000410046.3_Missense_Mutation_p.G141E|ZNF365_ENST00000466727.1_Intron|ZNF365_ENST00000395255.3_Missense_Mutation_p.G141E	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	200										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCGCTGGATGGGACACGGTCG	0.542000													10	70					0	0	1	0	0
TMX3	54495	broad.mit.edu	37	18	66344295	66344295	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr18:66344295T>C	ENST00000299608.2	-	16	1556	c.1240A>G	c.(1240-1242)Aaa>Gaa	p.K414E		NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	414					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TTTTCACTTTTAGACACTTCA	0.463000													16	141					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182369568	182369568	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:182369568T>G	ENST00000367565.1	-	1	183	c.53A>C	c.(52-54)cAa>cCa	p.Q18P		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	18						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						GGCACATCTTTGCTTATTCCT	0.448000													30	113					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610235	10610235	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:10610235C>A	ENST00000171111.5	-	2	1022	c.475G>T	c.(475-477)Gct>Tct	p.A159S	KEAP1_ENST00000393623.2_Missense_Mutation_p.A159S	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TACATGACAGCACCGTTCATG	0.582000													6	35					0.0215528	0.0217266	1	1	0
ADD1	118	broad.mit.edu	37	4	2886264	2886264	+	Silent	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:2886264G>C	ENST00000355842.3	+	5	1244	c.381G>C	c.(379-381)gtG>gtC	p.V127V	ADD1_ENST00000503455.2_Silent_p.V127V|ADD1_ENST00000446856.1_Silent_p.V127V|ADD1_ENST00000398123.2_Silent_p.V127V|ADD1_ENST00000398125.1_Silent_p.V127V|ADD1_ENST00000398129.1_Silent_p.V127V|ADD1_ENST00000264758.7_Silent_p.V127V|ADD1_ENST00000513328.2_Silent_p.V127V			P35611	ADDA_HUMAN	adducin 1 (alpha)	127					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGACTCCTGTGAACGATCTTA	0.423000													9	197					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130015687	130015687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:130015687A>T	ENST00000422113.2	-	3	1358	c.1032T>A	c.(1030-1032)gaT>gaA	p.D344E		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	344						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTCCTTGACATCCCAAATGG	0.537000													4	56					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2944663	2944663	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:2944663G>C	ENST00000520002.1	-	50	7988	c.7433C>G	c.(7432-7434)cCa>cGa	p.P2478R	CSMD1_ENST00000400186.3_Missense_Mutation_p.P2478R|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2478R|CSMD1_ENST00000537824.1_Missense_Mutation_p.P2477R|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2478R|CSMD1_ENST00000542608.1_Missense_Mutation_p.P2477R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2478	Sushi 14.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATGCCAAGTGGGTTTCGTCT	0.498000													7	60					0	0	1	0	0
POLR3H	171568	broad.mit.edu	37	22	41926706	41926706	+	Silent	SNP	A	A	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:41926706A>C	ENST00000355209.4	-	5	889	c.546T>G	c.(544-546)gcT>gcG	p.A182A	POLR3H_ENST00000396504.2_Silent_p.A182A|POLR3H_ENST00000337566.5_Silent_p.A153A|POLR3H_ENST00000407461.1_Silent_p.A182A	NM_001018050.2	NP_001018060.1	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)	182					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(1)|lung(5)|skin(1)|urinary_tract(1)	8						GCGTGTACGGAGCCTCCTTCT	0.627000													4	28					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90856622	90856622	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:90856622C>T	ENST00000394980.1	+	7	2110	c.1791C>T	c.(1789-1791)tcC>tcT	p.S597S	MMRN1_ENST00000394981.1_Intron|MMRN1_ENST00000508372.1_Silent_p.S339S|MMRN1_ENST00000264790.2_Silent_p.S597S			Q13201	MMRN1_HUMAN	multimerin 1	597					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ACATGTTATCCAAATGCAGAA	0.348000													7	76					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22155616	22155616	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:22155616T>A	ENST00000389398.5	+	26	2737	c.2641T>A	c.(2641-2643)Tgc>Agc	p.C881S	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	881						extracellular region		p.C881S(1)|p.C77S(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GATTTCCAGATGCATGGGTCC	0.438000													4	28					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9042630	9042630	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:9042630G>C	ENST00000457346.2	-	23	3123	c.3049C>G	c.(3049-3051)Cgt>Ggt	p.R1017G	SCUBE2_ENST00000450649.2_Missense_Mutation_p.R796G|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000520467.1_Missense_Mutation_p.R960G|SCUBE2_ENST00000309263.3_Missense_Mutation_p.R988G			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	988						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ACTTTGGAACGTAGCAATCGG	0.488000													10	53					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39481642	39481642	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:39481642C>T	ENST00000263881.3	-	32	2814	c.2490G>A	c.(2488-2490)gtG>gtA	p.V830V	MAP4K3_ENST00000437545.1_Silent_p.V746V|MAP4K3_ENST00000536018.1_Silent_p.V383V|MAP4K3_ENST00000341681.5_Silent_p.V809V	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	830	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				AGAAAGCTAGCACACTGTCTT	0.358000													11	93					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36832176	36832176	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:36832176G>A	ENST00000270001.7	-	5	667	c.552C>T	c.(550-552)cgC>cgT	p.R184R		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TAAGTGTTGAGCGACGAATAA	0.413000													21	135					0	0	1	0	0
LOC101927648	101927648	broad.mit.edu	37	1	143403554	143403554	+	RNA	SNP	T	T	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:143403554T>G	ENST00000423249.1	-	0	59																											GGAACAGGATTTCTTTGGCCA	0.468000													5	18					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36832177	36832177	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:36832177C>A	ENST00000270001.7	-	5	666	c.551G>T	c.(550-552)cGc>cTc	p.R184L		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					AAGTGTTGAGCGACGAATAAA	0.408000													21	136					1.96292e-10	2.45365e-10	1	1	0
ZNF236	7776	broad.mit.edu	37	18	74671705	74671705	+	Silent	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr18:74671705A>G	ENST00000253159.8	+	29	5367	c.5169A>G	c.(5167-5169)aaA>aaG	p.K1723K	ZNF236_ENST00000320610.9_Silent_p.K1725K	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1723					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GAGTGTTTAAATGTGACACTT	0.512000													7	49					0	0	1	0	0
SPATA17	128153	broad.mit.edu	37	1	217947767	217947767	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:217947767C>A	ENST00000366933.4	+	7	666	c.611C>A	c.(610-612)cCt>cAt	p.P204H		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	204						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		CACCGAAGACCTAAAGTTAAG	0.438000													9	91					3.86212e-05	4.3104e-05	1	1	0
EFR3A	23167	broad.mit.edu	37	8	132998476	132998476	+	Silent	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:132998476T>C	ENST00000254624.5	+	17	2130	c.1905T>C	c.(1903-1905)ttT>ttC	p.F635F	EFR3A_ENST00000334503.4_Silent_p.F635F|EFR3A_ENST00000519656.1_Silent_p.F599F	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	635						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CCCCTTATTTTCTACCAGAGC	0.313000													4	27					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7335023	7335023	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:7335023G>A	ENST00000318881.6	+	3	1132	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K	SYT9_ENST00000396716.2_Missense_Mutation_p.E267K	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	299	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAATGACCTTGAAGCACGGAA	0.453000													11	268					0	0	1	0	0
KATNBL1	79768	broad.mit.edu	37	15	34455835	34455835	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:34455835T>C	ENST00000256544.3	-	2	185	c.43A>G	c.(43-45)Aat>Gat	p.N15D		NM_024713.2	NP_078989.1			katanin p80 subunit B-like 1																		TCAATCTTATTACAAAAGTTC	0.294000													7	45					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175086232	175086232	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:175086232G>C	ENST00000239462.4	+	10	2390	c.2277G>C	c.(2275-2277)caG>caC	p.Q759H		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	759	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGAAGGAGCAGAGTAGCACTG	0.647000													6	140					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21804741	21804741	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:21804741A>T	ENST00000318220.6	+	12	1977	c.929A>T	c.(928-930)gAc>gTc	p.D310V	NBPF3_ENST00000318249.5_Missense_Mutation_p.D366V|NBPF3_ENST00000454000.2_Missense_Mutation_p.D296V|NBPF3_ENST00000342104.5_Intron			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	366	NBPF 1.					cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TACCAGTCTGACAGGAGCACC	0.512000													34	226					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344154	159344154	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:159344154A>G	ENST00000306675.3	+	1	365	c.242A>G	c.(241-243)aAc>aGc	p.N81S		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	81					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	ACGCCCACCAACTACTTCATT	0.622000													8	137					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91456505	91456505	+	Missense_Mutation	SNP	G	G	A	rs148275760		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:91456505G>A	ENST00000360468.3	+	17	2605	c.2587G>A	c.(2587-2589)Gtg>Atg	p.V863M	MAN2A2_ENST00000431652.2_Missense_Mutation_p.V371M|MAN2A2_ENST00000430376.2_Missense_Mutation_p.V53M|MAN2A2_ENST00000559717.1_Missense_Mutation_p.V863M	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	863					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTACCCAGGGGTGGAGGGGCT	0.607000													7	67					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815884	31815884	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr10:31815884G>A	ENST00000446923.2	+	9	3410	c.3019G>A	c.(3019-3021)Gac>Aac	p.D1007N	ZEB1_ENST00000560721.2_Missense_Mutation_p.D1003N|ZEB1_ENST00000320985.10_Missense_Mutation_p.D1023N|ZEB1_ENST00000361642.5_Missense_Mutation_p.D1024N|ZEB1_ENST00000542815.3_Missense_Mutation_p.D956N	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1023	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GGGCGACTCGGACGAGAGAGA	0.522000													3	29					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18070012	18070012	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:18070012C>T	ENST00000327451.5	+	8	1058	c.520C>T	c.(520-522)Ctc>Ttc	p.L174F	SLC25A18_ENST00000399813.1_Missense_Mutation_p.L174F|AC004019.13_ENST00000443935.1_RNA	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	174						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	CTGGGAGCTGCTCCGCACTCA	0.662000													10	126					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113314076	113314076	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:113314076C>G	ENST00000297405.5	-	53	8630	c.8386G>C	c.(8386-8388)Gta>Cta	p.V2796L	CSMD3_ENST00000352409.3_Missense_Mutation_p.V2726L|CSMD3_ENST00000343508.3_Missense_Mutation_p.V2756L|CSMD3_ENST00000455883.2_Missense_Mutation_p.V2627L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2796	Sushi 17.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CATTCCCTTACAGCAGAGCCC	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	79					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182743552	182743552	+	Silent	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:182743552A>G	ENST00000492597.1	-	14	2097	c.1395T>C	c.(1393-1395)taT>taC	p.Y465Y	MCCC1_ENST00000489909.1_5'UTR|MCCC1_ENST00000265594.4_Silent_p.Y574Y|MCCC1_ENST00000539926.1_Intron			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	574	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CCTGCATGCTATAAGACCCAT	0.368000													6	69					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625896	142625896	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:142625896G>T	ENST00000265310.1	-	6	1000	c.652C>A	c.(652-654)Ctg>Atg	p.L218M	TRPV5_ENST00000442623.1_Missense_Mutation_p.L218M	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	218					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GACAGCAGCAGGTTGTACATC	0.582000													13	74					4.36969e-10	5.40803e-10	1	1	0
RBFOX1	54715	broad.mit.edu	37	16	7637294	7637294	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:7637294G>A	ENST00000340209.4	+	4	772	c.475G>A	c.(475-477)Ggc>Agc	p.G159S	RBFOX1_ENST00000311745.5_Missense_Mutation_p.G174S|RBFOX1_ENST00000355637.4_Missense_Mutation_p.G174S|RBFOX1_ENST00000550418.1_Missense_Mutation_p.G154S|RBFOX1_ENST00000547372.1_Missense_Mutation_p.G197S|RBFOX1_ENST00000422070.4_Missense_Mutation_p.G197S|RBFOX1_ENST00000436368.2_Missense_Mutation_p.G174S|RBFOX1_ENST00000553186.1_Missense_Mutation_p.G154S|RBFOX1_ENST00000535565.2_Missense_Mutation_p.G142S|RBFOX1_ENST00000547338.1_Missense_Mutation_p.G154S|RBFOX1_ENST00000552089.1_Intron			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	154	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						TAATGAGCGAGGCTCAAAGGT	0.299000													9	82					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47385291	47385291	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:47385291G>T	ENST00000232766.5	+	10	1605	c.1585G>T	c.(1585-1587)Gtt>Ttt	p.V529F	KLHL18_ENST00000455924.2_Missense_Mutation_p.V417F	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	529										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CCTCTACGCTGTTGGGGGCTA	0.612000													17	86					1.15088e-07	1.34448e-07	1	1	0
YTHDF2	51441	broad.mit.edu	37	1	29069392	29069392	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:29069392C>G	ENST00000373812.3	+	4	972	c.610C>G	c.(610-612)Cca>Gca	p.P204A	YTHDF2_ENST00000478283.1_3'UTR|YTHDF2_ENST00000542507.1_Missense_Mutation_p.P204A|YTHDF2_ENST00000541996.1_Missense_Mutation_p.P154A	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	204					humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCAATGTTCCAAAAGTTGT	0.478000													11	64					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160793521	160793521	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:160793521T>C	ENST00000263285.5	+	8	1795	c.1765T>C	c.(1765-1767)Tat>Cat	p.Y589H	LY9_ENST00000368035.1_Missense_Mutation_p.Y227H|LY9_ENST00000368040.1_Missense_Mutation_p.Y227H|LY9_ENST00000368041.2_Missense_Mutation_p.Y459H|LY9_ENST00000341032.4_Missense_Mutation_p.Y455H	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	589					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CGTCACTCCATATGTCACGGA	0.512000													13	220					0	0	1	0	0
RUVBL1	8607	broad.mit.edu	37	3	127816180	127816180	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:127816180C>T	ENST00000464873.1	-	8	1549	c.799G>A	c.(799-801)Gtc>Atc	p.V267I	RUVBL1_ENST00000417360.1_Missense_Mutation_p.V327I|RUVBL1_ENST00000322623.5_Missense_Mutation_p.V327I			Q9Y265	RUVB1_HUMAN	RuvB-like AAA ATPase 1	327					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26				GBM - Glioblastoma multiforme(114;0.181)		GCAAAGATGACGATGGGAGCG	0.542000													8	26					0	0	1	0	0
ALDOC	230	broad.mit.edu	37	17	26902474	26902474	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:26902474G>T	ENST00000226253.4	-	2	552	c.77C>A	c.(76-78)cCg>cAg	p.P26Q	ALDOC_ENST00000395321.2_Missense_Mutation_p.P26Q|ALDOC_ENST00000395319.3_Missense_Mutation_p.P26Q	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	26					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					GCCTTTGCCCGGGGCTACAAT	0.572000											OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	69					2.7689e-08	3.328e-08	1	1	0
SMG8	55181	broad.mit.edu	37	17	57290862	57290862	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:57290862C>T	ENST00000543872.2	+	4	2942	c.2678C>T	c.(2677-2679)tCa>tTa	p.S893L	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.S893L			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	893					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TATATTCTGTCATCCTCTCAA	0.423000													9	157					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101833099	101833099	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:101833099G>T	ENST00000360264.3	+	12	1077	c.1057G>T	c.(1057-1059)Gaa>Taa	p.E353*	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000549414.2_Nonsense_Mutation_p.E342*|CUX1_ENST00000550008.2_Nonsense_Mutation_p.E342*|CUX1_ENST00000556210.1_Nonsense_Mutation_p.E342*|CUX1_ENST00000393824.3_Nonsense_Mutation_p.E314*|CUX1_ENST00000292538.4_Nonsense_Mutation_p.E353*|CUX1_ENST00000292535.7_Nonsense_Mutation_p.E342*|CUX1_ENST00000546411.2_Nonsense_Mutation_p.E342*|CUX1_ENST00000547394.2_Nonsense_Mutation_p.E337*|CUX1_ENST00000437600.4_Nonsense_Mutation_p.E351*|CUX1_ENST00000425244.2_Nonsense_Mutation_p.E307*	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	342					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCAGCAACTGGAAGAAAAACT	0.537000													10	35					3.07112e-06	3.45847e-06	1	1	0
BMPER	168667	broad.mit.edu	37	7	34085929	34085929	+	Silent	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:34085929A>T	ENST00000297161.2	+	8	962	c.588A>T	c.(586-588)acA>acT	p.T196T	BMPER_ENST00000494786.1_3'UTR|BMPER_ENST00000426693.1_Silent_p.T196T	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	196	VWFC 3.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						GAGGCAGGACACAATGTGTGA	0.438000													17	128					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36771546	36771546	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:36771546T>C	ENST00000280527.2	+	15	3018	c.2651T>C	c.(2650-2652)aTa>aCa	p.I884T	AC007401.2_ENST00000406220.1_Intron	NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	884					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CCAACCAATATACCCATTGAG	0.438000													10	98					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54902264	54902264	+	Missense_Mutation	SNP	G	G	A	rs149360088	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:54902264G>A	ENST00000293373.6	+	5	534	c.455G>A	c.(454-456)cGg>cAg	p.R152Q	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R102Q	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	152					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity	p.R152Q(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GAAGATCGGCGGATACTCATT	0.428000													25	238					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151107690	151107690	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:151107690C>G	ENST00000341697.3	-	15	3220	c.1529G>C	c.(1528-1530)tGt>tCt	p.C510S				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	510	Sema.					integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTAGACAATACAGCCAGAAAA	0.627000													7	92					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120395937	120395937	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:120395937G>C	ENST00000602047.1	+	21	2331	c.1219G>C	c.(1219-1221)Gag>Cag	p.E407Q	PCDP1_ENST00000413369.3_Missense_Mutation_p.E693Q			Q4G0U5	PCDP1_HUMAN		693						cilium	calmodulin binding					Colorectal(110;0.196)					ATTCACCAAAGAGTCCCGCCA	0.502000													7	160					0	0	1	0	0
GPR137B	7107	broad.mit.edu	37	1	236306205	236306205	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:236306205C>A	ENST00000366592.3	+	1	374	c.283C>A	c.(283-285)Ctc>Atc	p.L95I	GPR137B_ENST00000366591.4_Missense_Mutation_p.L95I	NM_003272.3	NP_003263.1	O60478	G137B_HUMAN	G protein-coupled receptor 137B	95						integral to plasma membrane|membrane fraction				endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GCGGACCGTCCTCTTCTCCTT	0.587000													22	142					9.86323e-18	1.28427e-17	1	1	0
ATP6V1G1	9550	broad.mit.edu	37	9	117359867	117359867	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:117359867C>T	ENST00000374050.3	+	3	294	c.201C>T	c.(199-201)ggC>ggT	p.G67G		NM_004888.3	NP_004879.1	O75348	VATG1_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	67					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances			endometrium(1)|lung(2)|prostate(1)|skin(1)	5						GATCCCGTGGCAGTTGCAGCA	0.512000													7	65					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33195270	33195270	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:33195270C>G	ENST00000309558.3	-	5	1271	c.854G>C	c.(853-855)gGa>gCa	p.G285A		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	285					cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAGCCGTGATCCTGGTGAATC	0.527000													5	64					0	0	1	0	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127654	32127654	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr21:32127654C>A	ENST00000335093.3	-	1	92	c.43G>T	c.(43-45)Ggc>Tgc	p.G15C		NM_181619.1	NP_853650.1	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	15			G -> S (in a breast cancer sample; somatic mutation).			intermediate filament		p.G15S(1)		breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7						cagccacagccggagccatag	0.537000													37	157					3.33393e-15	4.25247e-15	1	1	0
PDE5A	8654	broad.mit.edu	37	4	120446753	120446753	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:120446753C>T	ENST00000354960.3	-	12	2049	c.1730G>A	c.(1729-1731)cGg>cAg	p.R577Q	RP11-33B1.1_ENST00000498873.1_RNA|PDE5A_ENST00000394439.1_Missense_Mutation_p.R525Q|PDE5A_ENST00000264805.5_Missense_Mutation_p.R535Q|PDE5A_ENST00000512739.1_5'UTR	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	577					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AGTAAACATCCGAATTGTACA	0.443000													17	73					0	0	1	0	0
LRRC52	440699	broad.mit.edu	37	1	165513896	165513896	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:165513896C>T	ENST00000294818.1	+	1	653	c.363C>T	c.(361-363)ttC>ttT	p.F121F	RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000438275.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	121						integral to membrane		p.F121L(1)		NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CATTCACTTTCTCGGTGCTCA	0.498000													9	273					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52288786	52288786	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:52288786G>T	ENST00000371068.5	+	2	209	c.106G>T	c.(106-108)Ggc>Tgc	p.G36C	EFHC1_ENST00000538167.1_Missense_Mutation_p.G17C|EFHC1_ENST00000433625.2_5'UTR|EFHC1_ENST00000491749.1_3'UTR	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	36						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding	p.G36C(1)		breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					CTACAGGAACGGCTATGCAAT	0.463000													37	93					6.19805e-25	8.15533e-25	1	1	0
C6orf47	57827	broad.mit.edu	37	6	31626938	31626938	+	Missense_Mutation	SNP	G	G	A	rs114079572	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:31626938G>A	ENST00000375911.1	-	1	1611	c.787C>T	c.(787-789)Cgg>Tgg	p.R263W	C6orf47-AS1_ENST00000422049.1_RNA	NM_021184.3	NP_067007.3	O95873	CF047_HUMAN	chromosome 6 open reading frame 47	263										NS(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9						TTGGGCTCCCGGAGGCTGACA	0.632000													8	156					0	0	1	0	0
GRB2	2885	broad.mit.edu	37	17	73316622	73316622	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:73316622C>A	ENST00000392562.1	-	6	1263	c.481G>T	c.(481-483)Gtc>Ttc	p.V161F	GRB2_ENST00000578961.1_Silent_p.T104T|GRB2_ENST00000392563.1_Missense_Mutation_p.V120F|GRB2_ENST00000462266.1_5'UTR|GRB2_ENST00000392564.1_Missense_Mutation_p.V161F|GRB2_ENST00000316804.5_Missense_Mutation_p.V161F|GRB2_ENST00000316615.5_Missense_Mutation_p.V120F			P62993	GRB2_HUMAN	growth factor receptor-bound protein 2	161	SH3 2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	17	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	AGGGCCTGGACGTATGTCGGC	0.562000													8	50					7.48243e-07	8.58077e-07	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70964879	70964879	+	Silent	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:70964879G>T	ENST00000334414.6	-	13	3341	c.3297C>A	c.(3295-3297)ggC>ggA	p.G1099G	PTPRB_ENST00000261266.5_Silent_p.G881G|PTPRB_ENST00000551525.1_Silent_p.G1098G|PTPRB_ENST00000550857.1_Silent_p.G791G|PTPRB_ENST00000550358.1_Silent_p.G1011G|PTPRB_ENST00000538708.1_Silent_p.G881G|PTPRB_ENST00000451516.2_Silent_p.G791G	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	881	Fibronectin type-III 13.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGTATTGGCGGCCTGGTGTTA	0.428000													6	36					5.9392e-07	6.87407e-07	1	1	0
STAG3	10734	broad.mit.edu	37	7	99798718	99798718	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:99798718C>A	ENST00000426455.1	+	20	2474	c.2067C>A	c.(2065-2067)tcC>tcA	p.S689S	STAG3_ENST00000394018.2_Silent_p.S631S|STAG3_ENST00000440830.1_3'UTR|STAG3_ENST00000317296.5_Silent_p.S689S|GATS_ENST00000543273.1_RNA|GATS_ENST00000436886.2_3'UTR			Q9UJ98	STAG3_HUMAN	stromal antigen 3	689					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCAGTCGTCCTTCCTAGATG	0.517000													10	48					6.40141e-05	7.01909e-05	1	1	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832802	42832802	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:42832802G>A	ENST00000314073.5	+	13	3034	c.2858G>A	c.(2857-2859)aGc>aAc	p.S953N	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.S953N					GLTSCR1-like																		GGTACTGAGAGCAAACTGTCA	0.512000													5	69					0	0	1	0	0
ARL13B	200894	broad.mit.edu	37	3	93699219	93699219	+	Translation_Start_Site	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:93699219G>A	ENST00000535334.1	+	0	237				ARL13B_ENST00000394222.3_De_novo_Start_InFrame|ARL13B_ENST00000486562.1_3'UTR|ARL13B_ENST00000471138.1_De_novo_Start_InFrame|ARL13B_ENST00000539730.1_De_novo_Start_OutOfFrame|ARL13B_ENST00000303097.7_De_novo_Start_InFrame	NM_001174151.1	NP_001167622.1	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 13B								GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(2)	10						GCGGGGTGCCGGTGTCCGCTC	0.687000													20	66					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720584	140720584	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:140720584C>A	ENST00000394576.2	+	1	2046	c.2046C>A	c.(2044-2046)gcC>gcA	p.A682A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCCTCCGCCATACCCAACG	0.682000													8	190					0.00621372	0.00636651	1	1	0
KANK1	23189	broad.mit.edu	37	9	730172	730172	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:730172G>A	ENST00000382303.1	+	8	3472	c.2820G>A	c.(2818-2820)ctG>ctA	p.L940L	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Silent_p.L782L|KANK1_ENST00000382297.2_Silent_p.L940L	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	940					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TCAGCAGCCTGGATGCCTTCC	0.552000													4	47					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622444	234622444	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:234622444C>A	ENST00000373414.3	+	1	807	c.807C>A	c.(805-807)atC>atA	p.I269I	UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCAGGCCGATCATGCCCAACA	0.512000													41	182					3.76604e-16	4.85314e-16	1	1	0
ZFX	7543	broad.mit.edu	37	X	24228777	24228777	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:24228777A>T	ENST00000379177.1	+	11	2129	c.1702A>T	c.(1702-1704)Aga>Tga	p.R568*	ZFX_ENST00000304543.5_Nonsense_Mutation_p.R568*|ZFX_ENST00000540034.1_Nonsense_Mutation_p.R607*|ZFX_ENST00000539115.1_Nonsense_Mutation_p.R339*|ZFX_ENST00000379188.3_Nonsense_Mutation_p.R568*|ZFX_ENST00000338565.3_Nonsense_Mutation_p.R518*	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	568					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						AAAGCACATGAGAATCCATAC	0.458000													15	63					0	0	1	0	0
CAST	831	broad.mit.edu	37	5	96011290	96011290	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:96011290G>C	ENST00000395813.1	+	2	309	c.123G>C	c.(121-123)aaG>aaC	p.K41N	CAST_ENST00000325674.7_Missense_Mutation_p.K41N|CAST_ENST00000510756.1_Missense_Mutation_p.K41N|CAST_ENST00000395812.2_Missense_Mutation_p.K41N|CAST_ENST00000359176.4_Missense_Mutation_p.K41N|CAST_ENST00000338252.3_5'UTR|CAST_ENST00000508830.1_Missense_Mutation_p.K41N|CAST_ENST00000508608.1_Missense_Mutation_p.K26N			P20810	ICAL_HUMAN	calpastatin	106							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CAGGAGAAAAGAAAGGATCAG	0.338000													5	74					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93567613	93567613	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:93567613A>T	ENST00000394196.4	+	39	6233	c.5165A>T	c.(5164-5166)gAc>gTc	p.D1722V		NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1722					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CACCATCATGACTCCAAGCGG	0.493000													7	52					0	0	1	0	0
NHEJ1	79840	broad.mit.edu	37	2	219941078	219941078	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:219941078C>A	ENST00000409720.1	-	7	914	c.915G>T	c.(913-915)agG>agT	p.R305S	NHEJ1_ENST00000356853.5_3'UTR			Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	0					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	12		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		CCAAGTCCATCCTCAGCAGCT	0.493000								Non-homologous end-joining					7	50					1.06961e-07	1.26134e-07	1	1	0
RAPGEF6	51735	broad.mit.edu	37	5	130840380	130840380	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:130840380A>G	ENST00000509018.1	-	11	1398	c.1193T>C	c.(1192-1194)aTg>aCg	p.M398T	FNIP1_ENST00000514667.1_Missense_Mutation_p.M448T|RAPGEF6_ENST00000296859.6_Missense_Mutation_p.M398T|RAPGEF6_ENST00000507093.1_Missense_Mutation_p.M398T|RAPGEF6_ENST00000307984.5_Missense_Mutation_p.M398T|RAPGEF6_ENST00000510071.1_Missense_Mutation_p.M398T|RAPGEF6_ENST00000308008.6_Missense_Mutation_p.M398T|RAPGEF6_ENST00000512052.1_Missense_Mutation_p.M113T	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	398					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTCATGTACCATAACAATTTC	0.393000													12	121					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54785155	54785155	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:54785155C>A	ENST00000218436.6	-	8	1381	c.1352G>T	c.(1351-1353)cGc>cTc	p.R451L		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	451	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CTCATATATGCGCCGGGCTAT	0.577000													4	11					0.00909568	0.00924358	1	1	0
SSFA2	6744	broad.mit.edu	37	2	182774637	182774637	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:182774637G>A	ENST00000431877.2	+	9	1604	c.1425G>A	c.(1423-1425)acG>acA	p.T475T	SSFA2_ENST00000320370.7_Silent_p.T475T|SSFA2_ENST00000409001.1_Silent_p.T475T|SSFA2_ENST00000428267.2_Silent_p.T322T	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	475						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TTCAAAGTACGGAGGGAGAAG	0.373000													4	53					0	0	1	0	0
UBXN4	23190	broad.mit.edu	37	2	136537773	136537773	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:136537773C>T	ENST00000272638.9	+	12	1517	c.1206C>T	c.(1204-1206)tcC>tcT	p.S402S	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	402					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						CAACTGCATCCATTGTACACT	0.398000													9	119					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49568391	49568391	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:49568391C>T	ENST00000545947.1	+	6	1169	c.447C>T	c.(445-447)tcC>tcT	p.S149S	DAG1_ENST00000539901.1_Silent_p.S149S|DAG1_ENST00000308775.2_Silent_p.S149S|DAG1_ENST00000541308.1_Silent_p.S149S|DAG1_ENST00000538711.1_Silent_p.S149S|DAG1_ENST00000515359.2_Silent_p.S149S	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	149	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCCAGACCTCCAGTGTGTTCT	0.602000													8	35					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769932	31769932	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:31769932T>G	ENST00000240587.4	-	2	1094	c.767A>C	c.(766-768)aAg>aCg	p.K256T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	256					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TTTGCGAGGCTTGGACCAGCG	0.562000													34	221					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117712548	117712548	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:117712548G>A	ENST00000276204.6	+	13	1524	c.1450G>A	c.(1450-1452)Gta>Ata	p.V484I	DOCK11_ENST00000276202.7_Missense_Mutation_p.V484I|DOCK11_ENST00000498252.1_3'UTR			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	484					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AATTGAAAAGGTACTACAGGG	0.348000													4	53					0	0	1	0	0
TMEM41B	440026	broad.mit.edu	37	11	9321238	9321238	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:9321238C>A	ENST00000528080.1	-	2	470	c.132G>T	c.(130-132)tgG>tgT	p.W44C	TMEM41B_ENST00000533723.1_Missense_Mutation_p.W44C|TMEM41B_ENST00000527813.1_Missense_Mutation_p.W44C	NM_015012.3	NP_055827.1	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B	44						integral to membrane				kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(2)	7				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		CAGCTTCTACCCAGGATTTTT	0.323000													5	49					0.00116845	0.00122736	1	1	0
KALRN	8997	broad.mit.edu	37	3	124281895	124281895	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:124281895G>C	ENST00000360013.3	+	34	5262	c.5135G>C	c.(5134-5136)cGa>cCa	p.R1712P	KALRN_ENST00000393496.1_Missense_Mutation_p.R85P	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1712					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TCACACTCCCGAAGCAGCGTG	0.647000													10	65					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													3	45					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86504081	86504081	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:86504081C>G	ENST00000297814.2	-	7	2040	c.1897G>C	c.(1897-1899)Gaa>Caa	p.E633Q	KIF27_ENST00000334204.2_Missense_Mutation_p.E633Q|KIF27_ENST00000413982.1_Missense_Mutation_p.E633Q|KIF27_ENST00000376347.1_Missense_Mutation_p.E24Q	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	633					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TTATCTTGTTCTTCTATGTGA	0.413000													10	161					0	0	1	0	0
GPX6	257202	broad.mit.edu	37	6	28473575	28473575	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:28473575C>A	ENST00000361902.1	-	4	413	c.364G>T	c.(364-366)Gtg>Ttg	p.V122L	GPX6_ENST00000474923.1_Intron	NM_182701.1	NP_874360.1	P59796	GPX6_HUMAN	glutathione peroxidase 6 (olfactory)	122					response to oxidative stress	extracellular region	glutathione peroxidase activity			NS(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Glutathione(DB00143)	CCTGGACACACATACCTGCAG	0.433000													7	93					8.12818e-05	8.75882e-05	1	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262083	39262083	+	Missense_Mutation	SNP	A	A	C	rs75392608		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:39262083A>C	ENST00000391415.1	+	1	500	c.443A>C	c.(442-444)aAc>aCc	p.N148T		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	148	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						tgccagcccaactgctgccgc	0.667000													3	22					0	0	1	0	0
STEAP1	26872	broad.mit.edu	37	7	89790341	89790341	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:89790341C>G	ENST00000297205.2	+	3	507	c.307C>G	c.(307-309)Caa>Gaa	p.Q103E	STEAP2-AS1_ENST00000478318.2_RNA	NM_012449.2	NP_036581.1	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the prostate 1	103					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			kidney(2)|large_intestine(3)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	14	all_hematologic(106;0.112)					AACTTCCCATCAACAATATTT	0.393000													8	85					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187210	12187210	+	Silent	SNP	A	A	G	rs6511764	by1000genomes	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:12187210A>G	ENST00000439326.3	+	4	1450	c.1275A>G	c.(1273-1275)gtA>gtG	p.V425V	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TAAGCAGTGTAGTAAAGCCTT	0.428000													3	50					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41939949	41939949	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:41939949T>A	ENST00000301831.4	-	14	1785	c.1323A>T	c.(1321-1323)aaA>aaT	p.K441N	ULK4_ENST00000420927.1_Missense_Mutation_p.K441N	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	441							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GATGCAATATTTTTGCATCAA	0.289000													16	113					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262103	39262103	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:39262103A>T	ENST00000391415.1	+	1	520	c.463A>T	c.(463-465)Agc>Tgc	p.S155C		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	155	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						ccccagctgcagcatctccag	0.672000													3	18					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49246723	49246723	+	Nonsense_Mutation	SNP	G	G	A	rs146399718		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:49246723G>A	ENST00000332955.2	-	6	1025	c.478C>T	c.(478-480)Cga>Tga	p.R160*		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	160					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TAGGACTTTCGACAAGCGTGA	0.557000													4	36					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768243	31768243	+	Missense_Mutation	SNP	G	G	A	rs150738892	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:31768243G>A	ENST00000240587.4	-	2	2783	c.2456C>T	c.(2455-2457)tCa>tTa	p.S819L		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	819					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CACCGTGGATGAGGAGGTTGC	0.527000													6	72					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247162681	247162681	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:247162681G>A	ENST00000339986.7	-	3	375	c.228C>T	c.(226-228)aaC>aaT	p.N76N	ZNF695_ENST00000487338.2_Silent_p.N76N|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	76	KRAB.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTGTGTTCACGTTCCAGGGCT	0.468000													9	85					0	0	1	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012230	27012230	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:27012230C>T	ENST00000215939.2	-	2	184	c.54G>A	c.(52-54)ggG>ggA	p.G18G		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	18	N-terminal arm.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						TGGTGTCAGGCCCTGGGTTCA	0.627000													13	76					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33144245	33144245	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:33144245C>T	ENST00000341947.2	-	27	2361	c.2134G>A	c.(2134-2136)Gga>Aga	p.G712R	COL11A2_ENST00000395197.1_Missense_Mutation_p.G652R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Missense_Mutation_p.G691R|COL11A2_ENST00000374714.1_Missense_Mutation_p.G686R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G665R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G626R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G631R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G605R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	712	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCTAGAGGTCCCTGAGGTCCA	0.557000													4	38					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579155	54579155	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr20:54579155C>T	ENST00000064571.2	-	1	1373	c.73G>A	c.(73-75)Gtc>Atc	p.V25I		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	25						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TGTGCCCAGACGGGCAGCCCC	0.721000													3	24					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43191089	43191089	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:43191089G>T	ENST00000252050.4	+	39	7322	c.7238G>T	c.(7237-7239)cGg>cTg	p.R2413L	CUL9_ENST00000372647.2_Missense_Mutation_p.R2385L|CUL9_ENST00000354495.3_Missense_Mutation_p.R2303L|RP3-330M21.5_ENST00000500590.1_RNA	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	2413					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GAGCTGCTCCGGCGGATCCAG	0.677000													3	6					0.004672	0.00482645	1	1	0
KHSRP	8570	broad.mit.edu	37	19	6415180	6415180	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:6415180G>A	ENST00000398148.3	-	19	2191	c.2099C>T	c.(2098-2100)cCg>cTg	p.P700L		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	700					mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						CGTGGGCGGCGGCTGGGGGCC	0.662000													7	26					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308622	248308622	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:248308622C>A	ENST00000366476.1	+	1	173	c.173C>A	c.(172-174)cCc>cAc	p.P58H		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTCCACACCCCCATGTACTTC	0.522000													110	371					6.25226e-48	8.31417e-48	1	1	0
OR52K2	119774	broad.mit.edu	37	11	4470976	4470976	+	Missense_Mutation	SNP	A	A	C	rs147450058		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:4470976A>C	ENST00000325719.4	+	1	452	c.407A>C	c.(406-408)aAg>aCg	p.K136T		NM_001005172.2	NP_001005172.2	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|skin(6)	25		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACTACACCAAGGTCCTGACT	0.552000													9	73					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664021	169664021	+	RNA	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:169664021C>A	ENST00000483289.2	-	0	3273				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						GTAAGTGACTCCCCAAGATGC	0.502000													13	80					7.03913e-09	8.62638e-09	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66270177	66270177	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:66270177G>T	ENST00000273854.3	-	8	2305	c.1705C>A	c.(1705-1707)Caa>Aaa	p.Q569K	EPHA5_ENST00000354839.4_Missense_Mutation_p.Q569K|EPHA5_ENST00000432638.2_Missense_Mutation_p.Q406K|EPHA5_ENST00000511294.1_Missense_Mutation_p.Q570K	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	569					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ATCTGGCTTTGATCGCTGGAT	0.438000										TSP Lung(17;0.13)			11	48					6.40141e-05	7.01909e-05	1	1	0
CFHR5	81494	broad.mit.edu	37	1	196973882	196973882	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:196973882G>A	ENST00000367414.5	+	9	1550	c.1494G>A	c.(1492-1494)gtG>gtA	p.V498V	CFHR5_ENST00000256785.4_Silent_p.V474V	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	474	Sushi 8.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GGTCAACAGTGACGTACCGTT	0.458000													8	144					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585054	82585054	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:82585054C>T	ENST00000423517.2	-	5	5552	c.5215G>A	c.(5215-5217)Gag>Aag	p.E1739K	PCLO_ENST00000333891.8_Missense_Mutation_p.E1739K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1670					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCACTGTCCTCATCAAGTGAT	0.498000													12	157					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150789322	150789326	+	Frame_Shift_Del	DEL	GTTGG	GTTGG	-			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:150789322_150789326delGTTGG	ENST00000358595.5	-	18	1940_1944	c.1740_1744delCCAAC	c.(1738-1746)acagfs	p.TQQ580fs	ARNT_ENST00000515192.1_Frame_Shift_Del_p.TQQ566fs|ARNT_ENST00000505755.1_Frame_Shift_Del_p.TQQ565fs|ARNT_ENST00000354396.2_Frame_Shift_Del_p.TQQ580fs	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	580					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGAATAGCTGTTGGGTGGCAGGGA	0.556			T	ETV6	AML								18	87	---	---	---	---					
STK31	56164	broad.mit.edu	37	7	23775275	23775275	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:23775275delA	ENST00000354639.3	+	7	997	c.533delA	c.(532-534)gafs	p.E179fs	STK31_ENST00000355870.3_Frame_Shift_Del_p.E202fs|STK31_ENST00000428484.1_Frame_Shift_Del_p.E179fs|STK31_ENST00000433467.2_Frame_Shift_Del_p.E202fs|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	202							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GATATAGGGGAAGAGGTGCTT	0.398													23	116	---	---	---	---					
TRGC2	6967	broad.mit.edu	37	7	38284886	38284887	+	RNA	DEL	GT	GT	-	rs73692143		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:38284886_38284887delGT	ENST00000436911.2	-	0	330																											ATTTGTCAAGgtgtgtgtgtgt	0.391													7	141	---	---	---	---					
GRB10	2887	broad.mit.edu	37	7	50737429	50737430	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:50737429_50737430insC	ENST00000403097.1	-	6	1255_1256	c.475_476insG	c.(475-477)cgcfs	p.R159fs	GRB10_ENST00000406641.1_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000401949.1_Frame_Shift_Ins_p.R165fs|GRB10_ENST00000402497.1_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000335866.3_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000402578.1_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000398810.2_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000398812.2_Frame_Shift_Ins_p.R165fs|GRB10_ENST00000407526.1_Frame_Shift_Ins_p.R107fs|GRB10_ENST00000357271.5_Frame_Shift_Ins_p.R165fs|GRB10_ENST00000439599.1_Frame_Shift_Ins_p.R159fs			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	165					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CTGCTTTGCGGCGGCCTGGCTC	0.584									Russell-Silver syndrome				7	30	---	---	---	---					
