Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRAT1	50852	broad.mit.edu	37	3	108572480	108572480	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:108572480C>A	ENST00000295756.6	+	6	547	c.317C>A	c.(316-318)aCa>aAa	p.T106K	TRAT1_ENST00000426646.1_Missense_Mutation_p.T69K	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	106					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						ACCAATGAAACACAGATGTGC	0.408000													26	69					9.65021e-13	8.50576e-12	0.000339439	1	0
PKHD1	5314	broad.mit.edu	37	6	51893100	51893100	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:51893100A>T	ENST00000371117.3	-	30	3689	c.3414T>A	c.(3412-3414)gaT>gaA	p.D1138E	PKHD1_ENST00000340994.4_Missense_Mutation_p.D1138E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1138	IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCACATCCAAATCCGTATAGT	0.582000													5	76					0	0	8.12818e-05	0	0
OR10J5	127385	broad.mit.edu	37	1	159505080	159505080	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:159505080A>T	ENST00000334857.2	-	1	762	c.718T>A	c.(718-720)Tgt>Agt	p.C240S		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TGGGAGACACAGGTGGCAAAG	0.478000													7	73					0	0	0.000274275	0	0
NPR1	4881	broad.mit.edu	37	1	153659772	153659772	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:153659772G>A	ENST00000368680.3	+	13	2504	c.2032G>A	c.(2032-2034)Gac>Aac	p.D678N		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	678	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CAAGATCACCGACTATGGGCT	0.552000													22	42					0	0	0.000375601	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874171	48874171	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:48874171T>C	ENST00000394754.1	+	8	3194	c.3080T>C	c.(3079-3081)gTa>gCa	p.V1027A	LHCGR_ENST00000420913.3_5'UTR|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.V1027A|GTF2A1L_ENST00000403751.3_Missense_Mutation_p.V323A|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.V980A|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.V1027A|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.V1027A|GTF2A1L_ENST00000430487.2_Missense_Mutation_p.V289A	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		980					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AACATACCTGTATCAGAGAAG	0.378000													6	19					0	0	0.00116845	0	0
DEPDC1	55635	broad.mit.edu	37	1	68942745	68942745	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:68942745T>A	ENST00000456315.2	-	12	2420	c.2306A>T	c.(2305-2307)aAg>aTg	p.K769M	DEPDC1_ENST00000370966.5_Missense_Mutation_p.K485M	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	769					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		AGGATATTCCTTCTGAAACTT	0.343000													7	40					0	0	0.000274275	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175447	207175447	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:207175447C>A	ENST00000374423.3	+	5	6581	c.6195C>A	c.(6193-6195)ccC>ccA	p.P2065P		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2065							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTAGTCCTCCCCTGAGTGTAA	0.358000													5	21					0.000602214	0.00411005	0.000602214	1	0
KRT77	374454	broad.mit.edu	37	12	53097080	53097080	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:53097080C>T	ENST00000341809.3	-	1	167	c.139G>A	c.(139-141)Ggt>Agt	p.G47S	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	47	Head.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CCATATCCACCACCACCACAC	0.547000													16	53					0	0	0.00121646	0	0
SIK1	150094	broad.mit.edu	37	21	44840290	44840290	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr21:44840290G>A	ENST00000270162.6	-	8	928	c.796C>T	c.(796-798)Cgc>Tgc	p.R266C		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	266	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						ATGGTGATGCGCCTGGCGGGG	0.716000													4	22					0	0	0.00116845	0	0
CIT	11113	broad.mit.edu	37	12	120135822	120135822	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:120135822G>A	ENST00000392521.2	-	45	5716	c.5661C>T	c.(5659-5661)aaC>aaT	p.N1887N	CIT_ENST00000261833.7_Silent_p.N1845N|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1845					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTTCGAGTGAGTTGAAGTGGG	0.502000													9	192					0	0	0.000673444	0	0
FLG2	388698	broad.mit.edu	37	1	152327618	152327618	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:152327618A>G	ENST00000388718.5	-	3	2716	c.2644T>C	c.(2644-2646)Tct>Cct	p.S882P	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	882	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAAAGCCAGAGTATTGACCT	0.498000													72	516					0	0	0.000781405	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19687575	19687575	+	Splice_Site	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr21:19687575T>C	ENST00000284885.3	-	17	1955		c.e17-2			NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15						proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TGCATGGCTCTATGGGGAAAG	0.423000													19	19					0	0	0.00121646	0	0
IL17A	3605	broad.mit.edu	37	6	52053913	52053913	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:52053913G>T	ENST00000340057.1	+	3	336	c.291G>T	c.(289-291)ttG>ttT	p.L97F		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	97					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					GCCGCCACTTGGGCTGCATCA	0.567000													19	23					7.21436e-19	7.10898e-18	0.00121646	1	0
CCDC3	83643	broad.mit.edu	37	10	12940463	12940463	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:12940463G>A	ENST00000378839.1	-	7	1343	c.391C>T	c.(391-393)Cac>Tac	p.H131Y	CCDC3_ENST00000378825.3_Missense_Mutation_p.H256Y			Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	256						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			GCATTGATGTGCGGCAGCGCG	0.672000													15	27					0	0	0.000219431	0	0
MYH11	4629	broad.mit.edu	37	16	15876300	15876300	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:15876300G>T	ENST00000338282.6	-	6	774	c.668C>A	c.(667-669)cCg>cAg	p.P223Q	MYH11_ENST00000576790.1_Missense_Mutation_p.P223Q|MYH11_ENST00000452625.2_Missense_Mutation_p.P230Q|MYH11_ENST00000300036.5_Missense_Mutation_p.P223Q|MYH11_ENST00000396324.3_Missense_Mutation_p.P230Q	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	223	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTCCAGAATCGGGTTTGCTTG	0.448000			T	CBFB	AML								22	37					1.1804e-14	1.08399e-13	0.000586117	1	0
LINC00518	221718	broad.mit.edu	37	6	10430313	10430313	+	RNA	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:10430313C>A	ENST00000496285.1	-	0	722					NR_027793.1																						TGggacgggacgagtagccag	0.443000											OREG0017184	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	22					1.2644e-06	9.20235e-06	0.00152264	1	0
IGHA1	3493	broad.mit.edu	37	14	106173826	106173826	+	RNA	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:106173826C>G	ENST00000390547.2	-	0	740																											GGCACGTCAGCGTCACCAGCT	0.667000													25	35					0	0	0.00058488	0	0
DLG2	1740	broad.mit.edu	37	11	83182758	83182758	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:83182758C>T	ENST00000398309.2	-	19	2512	c.2042G>A	c.(2041-2043)cGg>cAg	p.R681Q	DLG2_ENST00000404783.3_Missense_Mutation_p.R159Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R786Q|DLG2_ENST00000543673.1_Missense_Mutation_p.R786Q|DLG2_ENST00000524982.1_Missense_Mutation_p.R677Q|DLG2_ENST00000376106.3_Missense_Mutation_p.R145Q|DLG2_ENST00000537455.1_Missense_Mutation_p.R431Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R720Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R602Q|DLG2_ENST00000426717.2_Missense_Mutation_p.R145Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R663Q|DLG2_ENST00000531015.1_Missense_Mutation_p.R648Q|DLG2_ENST00000418306.2_Missense_Mutation_p.R560Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	681	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				AATCACCGGCCGGGTGTAGTT	0.453000													8	42					0	0	0.000274275	0	0
PABPN1	8106	broad.mit.edu	37	14	23794478	23794478	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:23794478T>C	ENST00000216727.4	+	7	1085	c.904T>C	c.(904-906)Tgg>Cgg	p.W302R	BCL2L2-PABPN1_ENST00000553781.1_Missense_Mutation_p.W329R|BCL2L2-PABPN1_ENST00000557008.1_Missense_Mutation_p.W329R|PABPN1_ENST00000556821.1_Missense_Mutation_p.W174R|PABPN1_ENST00000397276.2_3'UTR	NM_004643.3	NP_004634.1			poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGCGACATCATGGTATTCCCC	0.408000													10	144					0	0	0.00136819	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													7	93					0	0	0.000157383	0	0
OR52A5	390054	broad.mit.edu	37	11	5153211	5153211	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:5153211T>A	ENST00000307388.1	-	1	661	c.662A>T	c.(661-663)tAt>tTt	p.Y221F		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AATTTGGACATAGGACAAGGT	0.413000													11	50					0	0	0.00185496	0	0
SKIDA1	387640	broad.mit.edu	37	10	21804562	21804562	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:21804562C>A	ENST00000449193.2	-	4	4442	c.2190G>T	c.(2188-2190)ttG>ttT	p.L730F	SKIDA1_ENST00000444772.3_Missense_Mutation_p.L651F	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		CTGTGGTTAACAAGGCGTCCT	0.428000													70	240					4.34595e-34	4.73465e-33	0.000781405	1	0
CAMTA1	23261	broad.mit.edu	37	1	7723642	7723642	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:7723642C>T	ENST00000303635.7	+	9	1242	c.1035C>T	c.(1033-1035)tcC>tcT	p.S345S	CAMTA1_ENST00000439411.2_Silent_p.S345S	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGTCTCCTCCACCAACCAGG	0.652000			T	WWTR1	epitheliod hemangioendothelioma								18	93					0	0	0.000295444	0	0
ZNF394	84124	broad.mit.edu	37	7	99097322	99097322	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:99097322C>A	ENST00000337673.6	-	1	598	c.395G>T	c.(394-396)gGg>gTg	p.G132V	ZNF394_ENST00000394177.3_5'UTR|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.G132V|ZNF789_ENST00000494186.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	132	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGCCTCCTCCCCGCTCTCTGG	0.647000													39	104					1.32136e-16	1.25279e-15	0.00195071	1	0
PSAP	5660	broad.mit.edu	37	10	73588830	73588830	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:73588830C>A	ENST00000394936.3	-	5	527	c.380G>T	c.(379-381)cGt>cTt	p.R127L	PSAP_ENST00000394934.1_Missense_Mutation_p.R127L			P07602	SAP_HUMAN	prosaposin	127	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						CTCCCCAGGACGGCTCTGGTG	0.517000													19	46					5.26018e-13	4.68343e-12	0.00188189	1	0
ADAM19	8728	broad.mit.edu	37	5	156915443	156915443	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:156915443G>T	ENST00000257527.4	-	21	2458	c.2380C>A	c.(2380-2382)Cct>Act	p.P794T	ADAM19_ENST00000517905.1_Missense_Mutation_p.P794T|ADAM19_ENST00000430702.2_Missense_Mutation_p.P527T|ADAM19_ENST00000394020.1_Missense_Mutation_p.P796T	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	794					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TAATCTGGAGGGGGCCGGGGA	0.602000													22	34					2.27525e-19	2.28045e-18	0.000586117	1	0
ZDHHC21	340481	broad.mit.edu	37	9	14658885	14658885	+	Splice_Site	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:14658885C>A	ENST00000380916.3	-	7	832	c.365_splice	c.e7-1	p.W122_splice		NM_178566.4	NP_848661.1	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	122					nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9				GBM - Glioblastoma multiforme(50;4.31e-06)		AATTGTTAATCCTAAAGAAAA	0.303000													20	38					6.44725e-10	5.16369e-09	0.000295444	1	0
ZHX2	22882	broad.mit.edu	37	8	123965337	123965337	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:123965337C>T	ENST00000314393.4	+	3	2422	c.1587C>T	c.(1585-1587)gcC>gcT	p.A529A		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	529						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CAGACTTTGCCCCCCAGAAGT	0.517000													7	62					0	0	8.12818e-05	0	0
MYT1L	23040	broad.mit.edu	37	2	1906916	1906916	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:1906916A>G	ENST00000399161.2	-	14	2715	c.1968T>C	c.(1966-1968)taT>taC	p.Y656Y	MYT1L_ENST00000428368.2_Silent_p.Y654Y	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	656					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Y656Y(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTCGCTTGCCATAAGTATGGT	0.483000													25	57					0	0	0.00178596	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616573	77616573	+	Nonsense_Mutation	SNP	G	G	T	rs144986646	by1000genomes	TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:77616573G>T	ENST00000521891.2	+	2	698	c.250G>T	c.(250-252)Gaa>Taa	p.E84*	ZFHX4_ENST00000455469.2_Nonsense_Mutation_p.E84*|ZFHX4_ENST00000050961.6_Nonsense_Mutation_p.E84*|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Nonsense_Mutation_p.E84*	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	84						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCCTGCAACGAATGTGCCAC	0.507000										HNSCC(33;0.089)			85	164					9.86815e-39	1.0886e-37	0.000781405	1	0
KCNQ4	9132	broad.mit.edu	37	1	41300770	41300770	+	Splice_Site	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:41300770G>C	ENST00000347132.5	+	12	1827	c.1745_splice	c.e12+1	p.R582_splice	KCNQ4_ENST00000506017.1_3'UTR|KCNQ4_ENST00000509682.2_Splice_Site_p.R528_splice	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	582	A-domain (Tetramerization).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CTGCAAACTCGGTGGGTGCAC	0.637000													15	65					0	0	0.000958276	0	0
DPP6	1804	broad.mit.edu	37	7	154672598	154672598	+	Splice_Site	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:154672598G>T	ENST00000404039.1	+	21	2474	c.1886_splice	c.e21-1	p.R629_splice	DPP6_ENST00000377770.3_Splice_Site_p.R693_splice|DPP6_ENST00000427557.1_Splice_Site_p.R586_splice|DPP6_ENST00000332007.3_Splice_Site_p.R631_splice	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	693					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GACCTCACAGGACGATGCTGA	0.552000													27	49					2.46105e-21	2.53923e-20	0.000339439	1	0
DCLRE1C	64421	broad.mit.edu	37	10	14978555	14978555	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:14978555T>A	ENST00000378289.4	-	5	765	c.344A>T	c.(343-345)cAc>cTc	p.H115L	DCLRE1C_ENST00000378278.2_Missense_Mutation_p.H115L|DCLRE1C_ENST00000357717.2_Intron|DCLRE1C_ENST00000378249.1_Intron|DCLRE1C_ENST00000378254.1_5'UTR|DCLRE1C_ENST00000378255.1_5'UTR|DCLRE1C_ENST00000396817.2_5'UTR|DCLRE1C_ENST00000378258.1_5'UTR|DCLRE1C_ENST00000453695.2_5'UTR|DCLRE1C_ENST00000378246.2_Intron			Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	115					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						TCCCGGACAGTGACCAGCTGG	0.318000								Non-homologous end-joining					12	27					0	0	0.000308642	0	0
CRYGA	1418	broad.mit.edu	37	2	209028094	209028094	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:209028094T>C	ENST00000304502.4	-	2	105	c.86A>G	c.(85-87)tAc>tGc	p.Y29C		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GCGGCTGAAGTAGACCCGCAG	0.557000													4	66					0	0	0.00024832	0	0
LRP1B	53353	broad.mit.edu	37	2	141946127	141946127	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:141946127C>A	ENST00000389484.3	-	7	1847	c.876G>T	c.(874-876)tgG>tgT	p.W292C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	292					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCGAGTGAGCCAGTCAATCG	0.403000										TSP Lung(27;0.18)			10	40					0.000151284	0.00105299	0.00185496	1	0
PCDHGA4	56111	broad.mit.edu	37	5	140736185	140736185	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:140736185C>A	ENST00000571252.1	+	1	1418	c.1418C>A	c.(1417-1419)tCt>tAt	p.S473Y	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATCTTATCTATGACTGCT	0.517000													21	96					7.88262e-20	8.03844e-19	0.00047179	1	0
FRMD7	90167	broad.mit.edu	37	X	131212726	131212726	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:131212726C>T	ENST00000298542.4	-	12	1494	c.1319G>A	c.(1318-1320)aGg>aAg	p.R440K	FRMD7_ENST00000370879.1_Missense_Mutation_p.R320K|FRMD7_ENST00000464296.1_Missense_Mutation_p.R425K	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	440					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					TAGAGAACTCCTCTCTGAAAA	0.438000													73	49					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9021069	9021069	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:9021069C>T	ENST00000397910.4	-	19	37457	c.37254G>A	c.(37252-37254)agG>agA	p.R12418R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12420	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTGCAGGACCCTCTCTGTGG	0.542000													6	113					0	0	0.00116845	0	0
ZNF331	55422	broad.mit.edu	37	19	54081028	54081028	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:54081028A>T	ENST00000253144.9	+	7	2547	c.1214A>T	c.(1213-1215)cAt>cTt	p.H405L	ZNF331_ENST00000511154.1_Missense_Mutation_p.H405L|ZNF331_ENST00000512387.1_Missense_Mutation_p.H405L|ZNF331_ENST00000411977.2_Missense_Mutation_p.H405L|ZNF331_ENST00000449416.1_Missense_Mutation_p.H405L|ZNF331_ENST00000513999.1_Missense_Mutation_p.H405L|ZNF331_ENST00000511593.2_Missense_Mutation_p.H405L	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GAGAGAATTCATACCGGGGTG	0.488000			T	?	follicular thyroid adenoma								12	17					0	0	0.000219431	0	0
PLB1	151056	broad.mit.edu	37	2	28761239	28761239	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:28761239G>T	ENST00000422425.2	+	10	686	c.642G>T	c.(640-642)ctG>ctT	p.L214L	PLB1_ENST00000327757.5_Silent_p.L203L	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	203	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TGGACTACCTGCAGCAGGAGG	0.652000													7	22					6.5536e-12	5.63481e-11	0.000157383	1	0
UFD1L	7353	broad.mit.edu	37	22	19444129	19444129	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:19444129G>C	ENST00000263202.9	-	9	788	c.659C>G	c.(658-660)gCt>gGt	p.A220G	UFD1L_ENST00000399523.1_Missense_Mutation_p.A220G|UFD1L_ENST00000360834.4_Missense_Mutation_p.A209G	NM_001035247.2|NM_005659.6	NP_001030324.2|NP_005650.2	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1 like (yeast)	220					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity			large_intestine(3)|upper_aerodigestive_tract(1)	4	Colorectal(54;0.0993)					CAGCTCTCCAGCATAGCCACT	0.557000													16	93					0	0	0.000295444	0	0
RP1L1	94137	broad.mit.edu	37	8	10466437	10466437	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:10466437T>A	ENST00000382483.3	-	4	5394	c.5171A>T	c.(5170-5172)cAg>cTg	p.Q1724L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1724					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCAGCTCCCTGGACAGTCCT	0.642000													47	97					0	0	0.000781405	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508598	37508598	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:37508598G>T	ENST00000374660.1	+	40	4246	c.4147G>T	c.(4147-4149)Gat>Tat	p.D1383Y	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.D1264Y|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.D1264Y			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1320						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGAGTCTCTAGATCAGAAATT	0.358000													15	33					1.5739e-10	1.29001e-09	0.000422831	1	0
SV2C	22987	broad.mit.edu	37	5	75587140	75587140	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:75587140G>T	ENST00000502798.2	+	7	1674	c.1232G>T	c.(1231-1233)cGc>cTc	p.R411L	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Missense_Mutation_p.R411L	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	411					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GTTCGGATCCGCACCGAGCTG	0.423000													21	41					1.85244e-09	1.45053e-08	0.00047179	1	0
OR2B11	127623	broad.mit.edu	37	1	247614761	247614761	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:247614761C>T	ENST00000318749.6	-	1	547	c.524G>A	c.(523-525)cGg>cAg	p.R175Q		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CAGCACCTGCCGCCCGCAGAA	0.602000													7	20					0	0	0.000157383	0	0
FLNC	2318	broad.mit.edu	37	7	128494262	128494262	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:128494262A>C	ENST00000325888.8	+	40	6980	c.6719A>C	c.(6718-6720)cAg>cCg	p.Q2240P	FLNC_ENST00000346177.6_Missense_Mutation_p.Q2207P|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2240	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ATCACCCGGCAGCAGGAGGGT	0.706000													6	29					0	0	0.000673444	0	0
NUP155	9631	broad.mit.edu	37	5	37370993	37370993	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:37370993G>A	ENST00000231498.3	-	1	290	c.87C>T	c.(85-87)ctC>ctT	p.L29L	NUP155_ENST00000513532.1_Silent_p.L29L	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	29					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACGGTCGATGAGCCGTCCAG	0.577000													15	49					0	0	0.000308642	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128945479	128945479	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:128945479C>A	ENST00000357166.6	-	9	1175	c.784G>T	c.(784-786)Gga>Tga	p.G262*	ZDHHC9_ENST00000371064.3_Nonsense_Mutation_p.G262*	NM_016032.3	NP_057116.2	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC-type containing 9	262						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	19						GTCCATGATCCTTTGATCTGC	0.378000													17	8					1.01871e-10	8.46835e-10	0.00121646	1	0
UNC45B	146862	broad.mit.edu	37	17	33504085	33504085	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:33504085C>A	ENST00000268876.5	+	16	2178	c.2081C>A	c.(2080-2082)gCa>gAa	p.A694E	UNC45B_ENST00000394570.2_Missense_Mutation_p.A692E|UNC45B_ENST00000591048.1_Missense_Mutation_p.A613E|UNC45B_ENST00000433649.1_Missense_Mutation_p.A692E|UNC45B_ENST00000378449.1_Missense_Mutation_p.A613E	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	694					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				AAGGTGAAGGCAGCCCACGCT	0.562000													23	69					4.59853e-10	3.71697e-09	0.000878237	1	0
STK31	56164	broad.mit.edu	37	7	23871859	23871859	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:23871859A>G	ENST00000354639.3	+	24	3329	c.2865A>G	c.(2863-2865)caA>caG	p.Q955Q	STK31_ENST00000355870.3_Silent_p.Q978Q|STK31_ENST00000428484.1_Silent_p.Q955Q|STK31_ENST00000433467.2_Silent_p.Q955Q|STK31_ENST00000405627.3_3'UTR	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	978	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CAAAGGAGCAATCAGTTCCAA	0.348000													8	73					0	0	0.000274275	0	0
SALL1	6299	broad.mit.edu	37	16	51173390	51173390	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:51173390C>T	ENST00000440970.1	-	2	2883	c.2452G>A	c.(2452-2454)Ggc>Agc	p.G818S	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.G915S	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	915					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GCTGGGCTGCCAGCACTTTGG	0.562000													11	48					0	0	0.000219431	0	0
CSMD3	114788	broad.mit.edu	37	8	113599308	113599308	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:113599308C>A	ENST00000297405.5	-	23	4116	c.3872G>T	c.(3871-3873)gGa>gTa	p.G1291V	CSMD3_ENST00000455883.2_Missense_Mutation_p.G1187V|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1291V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1251V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1291	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAGAACATCTCCTTGTGCTAA	0.299000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	57					2.49991e-28	2.69009e-27	0.00058488	1	0
SLC2A7	155184	broad.mit.edu	37	1	9063388	9063388	+	Missense_Mutation	SNP	C	C	A	rs150069373	by1000genomes	TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:9063388C>A	ENST00000400906.1	-	12	1509	c.1510G>T	c.(1510-1512)Gcc>Tcc	p.A504S		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	504						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GCAGGAGAGGCTGTGGGAGGC	0.522000													17	29					1.56452e-12	1.37209e-11	0.000958276	1	0
MUC16	94025	broad.mit.edu	37	19	9074336	9074336	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:9074336G>T	ENST00000397910.4	-	3	13313	c.13110C>A	c.(13108-13110)agC>agA	p.S4370R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4372	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGGTTGGTGCTCACATCTG	0.473000													16	20					6.49762e-13	5.75597e-12	0.00074312	1	0
ZFHX4	79776	broad.mit.edu	37	8	77763811	77763811	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:77763811C>G	ENST00000521891.2	+	10	5102	c.4654C>G	c.(4654-4656)Caa>Gaa	p.Q1552E	ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q1507E|ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q1507E|ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q1526E	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1507						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTCATTCACCCAAAAGAACAT	0.403000										HNSCC(33;0.089)			5	27					0	0	0.00116845	0	0
SDK1	221935	broad.mit.edu	37	7	3998580	3998580	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:3998580G>T	ENST00000404826.2	+	8	1307	c.1168G>T	c.(1168-1170)Gct>Tct	p.A390S	SDK1_ENST00000389531.3_Missense_Mutation_p.A390S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	390	Ig-like C2-type 4.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ATATTTTACTGCTGAGCCCGA	0.463000													32	108					8.01111e-26	8.46475e-25	0.000509022	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73179510	73179510	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:73179510C>T	ENST00000286657.4	-	12	1665	c.1629G>A	c.(1627-1629)aaG>aaA	p.K543K		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	543	Disintegrin.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GATTAGCATTCTTCCACATGC	0.403000													13	87					0	0	0.000308642	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117375356	117375356	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:117375356G>A	ENST00000160373.3	-	15	3746	c.3655C>T	c.(3655-3657)Cgc>Tgc	p.R1219C		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1219										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TCAGTGCTGCGATTTTCAAGA	0.383000													12	63					0	0	0.00136819	0	0
GALNT3	2591	broad.mit.edu	37	2	166613653	166613653	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:166613653A>C	ENST00000392701.3	-	7	2071	c.1296T>G	c.(1294-1296)atT>atG	p.I432M	GALNT3_ENST00000409882.1_Missense_Mutation_p.I170M	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	432					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						GGTTTCTAGCAATCACCTGAG	0.413000													9	70					0	0	0.00185496	0	0
TMTC1	83857	broad.mit.edu	37	12	29786115	29786115	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:29786115C>T	ENST00000256062.5	-	6	1242	c.769G>A	c.(769-771)Gcc>Acc	p.A257T	TMTC1_ENST00000381224.2_Missense_Mutation_p.A319T|TMTC1_ENST00000552618.1_Missense_Mutation_p.A427T|TMTC1_ENST00000539277.1_Missense_Mutation_p.A365T|TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000551659.1_Missense_Mutation_p.A427T	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	365						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CTCAATAAGGCCATCACAACC	0.458000													38	55					0	0	0.00170553	0	0
MUC4	4585	broad.mit.edu	37	3	195508343	195508343	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:195508343A>T	ENST00000463781.3	-	2	10567	c.10108T>A	c.(10108-10110)Tcc>Acc	p.S3370T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.S3370T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	147					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TCACCTGTGGAAGCTGAGGAA	0.587000													3	2					0	0	0.00024832	0	0
IQUB	154865	broad.mit.edu	37	7	123101456	123101456	+	Silent	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:123101456T>C	ENST00000466202.1	-	11	2538	c.1962A>G	c.(1960-1962)acA>acG	p.T654T	IQUB_ENST00000324698.6_Silent_p.T654T			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	654										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						AATCAGCTTCTGTATAGTAGA	0.378000													16	88					0	0	0.00074312	0	0
TAF1L	138474	broad.mit.edu	37	9	32631721	32631721	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:32631721C>T	ENST00000242310.4	-	1	3946	c.3857G>A	c.(3856-3858)tGt>tAt	p.C1286Y		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1286					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AATGGCACCACATGCCCCACA	0.468000													22	71					0	0	0.000295444	0	0
VIT	5212	broad.mit.edu	37	2	37028445	37028445	+	Splice_Site	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:37028445G>A	ENST00000379242.3	+	13	1362	c.1058_splice	c.e13-1	p.D354_splice	VIT_ENST00000389975.3_Splice_Site_p.D339_splice|VIT_ENST00000404084.1_Splice_Site_p.D291_splice|VIT_ENST00000401530.1_Splice_Site_p.D318_splice|VIT_ENST00000497382.1_Splice_Site_p.D8_splice|VIT_ENST00000379241.3_Splice_Site_p.D317_splice	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	339	VWFA 1.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				ACTCTTCAGAGACAACCCTGC	0.383000													33	209					0	0	0.00195071	0	0
UBE3A	7337	broad.mit.edu	37	15	25650638	25650638	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:25650638G>A	ENST00000232165.3	-	4	688	c.32C>T	c.(31-33)cCt>cTt	p.P11L	UBE3A_ENST00000566215.1_5'UTR|UBE3A_ENST00000428984.2_5'UTR|UBE3A_ENST00000438097.1_5'UTR|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000397954.2_Missense_Mutation_p.P14L	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	14					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTCAGACTGAGGTTCTCCTGA	0.353000													20	59					0	0	0.00047179	0	0
CACNA1B	774	broad.mit.edu	37	9	140952585	140952585	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:140952585G>T	ENST00000277549.5	+	29	4348	c.1779G>T	c.(1777-1779)gtG>gtT	p.V593V	CACNA1B_ENST00000277551.2_Silent_p.V1397V|CACNA1B_ENST00000371357.1_Silent_p.V1398V|CACNA1B_ENST00000371363.1_Silent_p.V1397V|CACNA1B_ENST00000371355.4_Silent_p.V1398V|CACNA1B_ENST00000371372.1_Silent_p.V1397V			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1397					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCTTCTACGTGGTCTACTTTG	0.527000													6	57					2.7689e-08	2.0844e-07	8.12818e-05	1	0
OPRD1	4985	broad.mit.edu	37	1	29189269	29189269	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:29189269G>T	ENST00000234961.2	+	3	835	c.593G>T	c.(592-594)tGc>tTc	p.C198F		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	198					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	GCAGTGGTGTGCATGCTCCAG	0.627000													7	25					0.000274275	0.00189401	0.000274275	1	0
EIF4G2	1982	broad.mit.edu	37	11	10819410	10819410	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:10819410A>T	ENST00000526148.1	-	22	3187	c.2677T>A	c.(2677-2679)Tgg>Agg	p.W893R	EIF4G2_ENST00000396525.2_Missense_Mutation_p.W855R|EIF4G2_ENST00000525681.1_Missense_Mutation_p.W893R|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000339995.5_Missense_Mutation_p.W893R	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	893	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTTTCTAACCAGGTTAGCCAC	0.343000													13	79					0	0	0.000219431	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209862	140209862	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:140209862A>T	ENST00000529310.1	+	1	2300	c.2186A>T	c.(2185-2187)gAg>gTg	p.E729V	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCCACCGAGGGCGCGTGC	0.677000													10	42					0	0	0.000978159	0	0
C20orf166	128826	broad.mit.edu	37	20	61150840	61150840	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr20:61150840A>G	ENST00000370524.2	+	2	755	c.34A>G	c.(34-36)Agg>Ggg	p.R12G	C20orf166_ENST00000370527.3_5'UTR|C20orf166_ENST00000370523.1_Missense_Mutation_p.R12G			Q9H1L0	CT166_HUMAN	chromosome 20 open reading frame 166	0										endometrium(1)|kidney(1)|lung(2)	4	Breast(26;1.04e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			AGCCTTCACCAGGGACCTGCC	0.617000													18	13					0	0	0.000958276	0	0
EBF3	253738	broad.mit.edu	37	10	131639112	131639112	+	Silent	SNP	G	G	A	rs147171591		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:131639112G>A	ENST00000368648.3	-	14	1602	c.1530C>T	c.(1528-1530)taC>taT	p.Y510Y	EBF3_ENST00000355311.5_Silent_p.Y519Y	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	519	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		ACTTACTGCCGTAGGGAGAGT	0.507000													13	72					0	0	0.00185496	0	0
PAX1	5075	broad.mit.edu	37	20	21687131	21687131	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr20:21687131C>A	ENST00000398485.2	+	2	396	c.342C>A	c.(340-342)ccC>ccA	p.P114P	PAX1_ENST00000460221.1_Intron|PAX1_ENST00000444366.2_Silent_p.P90P	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	114	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						ACGGCCGCCCCCTGCCCAACG	0.652000													21	39					3.5997e-14	3.28848e-13	0.000295444	1	0
F2R	2149	broad.mit.edu	37	5	76028263	76028263	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:76028263A>T	ENST00000319211.4	+	2	478	c.213A>T	c.(211-213)ttA>ttT	p.L71F		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	71					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	AATACAGATTAGTCTCCATCA	0.418000													17	115					0	0	0.00074312	0	0
MCTP2	55784	broad.mit.edu	37	15	95013670	95013670	+	Splice_Site	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:95013670G>T	ENST00000357742.4	+	20	2469	c.2470_splice	c.e20+1	p.W823_splice	MCTP2_ENST00000451018.3_Splice_Site_p.W768_splice	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	823					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding	p.W823C(1)		autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TTTTAATCTGGGGTAAGTTTG	0.403000													30	56					2.42023e-17	2.33247e-16	0.00058488	1	0
ADCY5	111	broad.mit.edu	37	3	123018992	123018992	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:123018992C>A	ENST00000462833.1	-	15	4087	c.2875G>T	c.(2875-2877)Gac>Tac	p.D959Y	ADCY5_ENST00000309879.5_Missense_Mutation_p.D609Y|ADCY5_ENST00000491190.1_Missense_Mutation_p.D592Y	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	959					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding	p.D959N(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		ACCAGCAGGTCGGCGTTGTCG	0.612000													44	27					2.74695e-27	2.9379e-26	0.000781405	1	0
FBXO43	286151	broad.mit.edu	37	8	101149819	101149819	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:101149819T>A	ENST00000428847.2	-	3	1964	c.1648A>T	c.(1648-1650)Atc>Ttc	p.I550F		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	550					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AGTTGTGTGATATAAAATTTC	0.303000													9	49					0	0	0.000978159	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678549	37678549	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr13:37678549C>T	ENST00000379800.3	-	1	1254	c.845G>A	c.(844-846)cGc>cAc	p.R282H		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	282	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GAAAAGAATGCGGAATAGCTG	0.488000													13	85					0	0	0.000219431	0	0
NR2F1	7025	broad.mit.edu	37	5	92924056	92924056	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:92924056C>A	ENST00000327111.3	+	2	2584	c.897C>A	c.(895-897)atC>atA	p.I299I		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	299					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		TGGACCACATCCGCATCTTCC	0.642000													27	39					3.00307e-07	2.23194e-06	0.001512	1	0
COL12A1	1303	broad.mit.edu	37	6	75898122	75898122	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:75898122G>T	ENST00000322507.8	-	8	1262	c.953C>A	c.(952-954)tCa>tAa	p.S318*	COL12A1_ENST00000416123.2_Nonsense_Mutation_p.S318*|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Nonsense_Mutation_p.S318*	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	318					cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ATCAACACCTGAGCACACCTG	0.413000													53	84					9.77497e-20	9.91058e-19	0.000781405	1	0
JPH1	56704	broad.mit.edu	37	8	75227127	75227127	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:75227127C>T	ENST00000342232.4	-	2	1148	c.1108G>A	c.(1108-1110)Gcc>Acc	p.A370T		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	370	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTGGTTCTGGCCATGGCAGCT	0.448000													11	154					0	0	0.00185496	0	0
NAV2	89797	broad.mit.edu	37	11	19954915	19954915	+	Silent	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:19954915G>C	ENST00000396085.1	+	7	1486	c.1125G>C	c.(1123-1125)tcG>tcC	p.S375S	NAV2_ENST00000396087.3_Silent_p.S398S|NAV2_ENST00000349880.4_Silent_p.S375S|NAV2_ENST00000540292.1_Silent_p.S329S|NAV2_ENST00000360655.4_Silent_p.S311S|NAV2_ENST00000527559.2_Silent_p.S327S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	398						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CCATGCTCTCGGTCAAGCCTC	0.612000													11	142					0	0	0.00136819	0	0
UBAP2	55833	broad.mit.edu	37	9	33923984	33923984	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:33923984A>C	ENST00000379238.1	-	24	2722	c.2605T>G	c.(2605-2607)Ttt>Gtt	p.F869V	UBAP2_ENST00000379239.4_Missense_Mutation_p.F602V|UBAP2_ENST00000449054.1_Missense_Mutation_p.F869V|UBAP2_ENST00000360802.1_Missense_Mutation_p.F869V|UBAP2_ENST00000379235.1_Missense_Mutation_p.F108V|UBAP2_ENST00000539807.1_Missense_Mutation_p.F624V			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	869										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		CCACGGCCAAACTTTGTGACA	0.587000													8	82					0	0	0.000274275	0	0
KRTAP5-AS1	338651	broad.mit.edu	37	11	1619527	1619527	+	RNA	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:1619527G>A	ENST00000424148.1	+	0	1378					NR_021489.1																						CAGGTGAGAGGGAGGTGCAGG	0.582000													31	111					0	0	0.000692331	0	0
TSSK4	283629	broad.mit.edu	37	14	24676565	24676565	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:24676565C>A	ENST00000339917.5	+	3	888	c.684C>A	c.(682-684)ttC>ttA	p.F228L	TM9SF1_ENST00000530611.1_Intron|TSSK4_ENST00000287913.6_Missense_Mutation_p.F218L|TSSK4_ENST00000428351.2_Intron|TSSK4_ENST00000556621.1_Missense_Mutation_p.F142L|TM9SF1_ENST00000556387.1_Intron	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	218	Protein kinase.				cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		ACAACCCTTTCCTGTCTGACA	0.522000													18	70					1.33834e-09	1.05266e-08	0.000958276	1	0
ACTL9	284382	broad.mit.edu	37	19	8808746	8808746	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:8808746G>T	ENST00000324436.3	-	1	426	c.306C>A	c.(304-306)gcC>gcA	p.A102A		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	102						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						GGAGCACGCGGGCTGCCTCGC	0.701000													5	9					5.9392e-07	4.34057e-06	0.00116845	1	0
TRPA1	8989	broad.mit.edu	37	8	72936135	72936135	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:72936135A>C	ENST00000262209.4	-	26	3270	c.3063T>G	c.(3061-3063)tgT>tgG	p.C1021W	RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	1021						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AAAATAAAAAACAGAATATAT	0.308000													6	97					0	0	0.000274275	0	0
EBF1	1879	broad.mit.edu	37	5	158158077	158158077	+	Splice_Site	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:158158077C>A	ENST00000313708.6	-	11	1407	c.1125_splice	c.e11+1	p.K375_splice	EBF1_ENST00000380654.4_Splice_Site_p.K344_splice|EBF1_ENST00000517373.1_Splice_Site_p.K367_splice|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	375					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTATCCTCACCTTTGGCAAAC	0.443000			T	HMGA2	lipoma								11	26					4.3838e-07	3.21723e-06	0.00185496	1	0
IGHG2	3501	broad.mit.edu	37	14	106109816	106109816	+	RNA	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:106109816C>G	ENST00000390545.2	-	0	704																											TGGTCATCTCCTCCCGGGATG	0.637000													21	190					0	0	0.00106085	0	0
F2R	2149	broad.mit.edu	37	5	76028264	76028264	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:76028264G>T	ENST00000319211.4	+	2	479	c.214G>T	c.(214-216)Gtc>Ttc	p.V72F		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	72					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATACAGATTAGTCTCCATCAA	0.418000													17	113					6.94344e-10	5.51077e-09	0.00074312	1	0
PTK2B	2185	broad.mit.edu	37	8	27311715	27311715	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:27311715G>T	ENST00000397501.1	+	34	3448	c.2640G>T	c.(2638-2640)gtG>gtT	p.V880V	PTK2B_ENST00000544172.1_Silent_p.V880V|PTK2B_ENST00000420218.2_Silent_p.V838V|PTK2B_ENST00000517339.1_Silent_p.V838V|PTK2B_ENST00000338238.4_Silent_p.V838V|PTK2B_ENST00000346049.5_Silent_p.V880V	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	880	Focal adhesion targeting (FAT).|Interaction with TGFB1I1 (By similarity).				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		ATGACCTGGTGTACCTCAATG	0.617000													28	65					2.81731e-10	2.28776e-09	0.000339439	1	0
DSEL	92126	broad.mit.edu	37	18	65180364	65180364	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr18:65180364C>A	ENST00000310045.7	-	2	2985	c.1512G>T	c.(1510-1512)ttG>ttT	p.L504F	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	494						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TAAGGTGGCTCAACTTGGGTC	0.458000													26	44					1.75199e-13	1.57589e-12	0.00127121	1	0
MYOM2	9172	broad.mit.edu	37	8	2092778	2092778	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:2092778A>G	ENST00000262113.4	+	37	4412	c.4271A>G	c.(4270-4272)tAt>tGt	p.Y1424C	MYOM2_ENST00000520298.1_3'UTR|MYOM2_ENST00000523438.1_Missense_Mutation_p.Y849C	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1424	Ig-like C2-type 5.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAGAATAAGTATGGCGGGGAG	0.572000													14	83					0	0	0.000422831	0	0
KCNH6	81033	broad.mit.edu	37	17	61613174	61613174	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:61613174G>A	ENST00000583023.1	+	6	1257	c.1246G>A	c.(1246-1248)Gcc>Acc	p.A416T	KCNH6_ENST00000581784.1_Missense_Mutation_p.A416T|KCNH6_ENST00000580652.1_Missense_Mutation_p.A416T|KCNH6_ENST00000314672.5_Missense_Mutation_p.A416T|KCNH6_ENST00000456941.2_Missense_Mutation_p.A416T	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	416					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GCACTGGCTGGCCTGCATCTG	0.612000													27	41					0	0	0.000491102	0	0
KIAA0232	9778	broad.mit.edu	37	4	6864324	6864324	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:6864324G>T	ENST00000307659.5	+	7	2670	c.2215G>T	c.(2215-2217)Gcc>Tcc	p.A739S	KIAA0232_ENST00000425103.1_Missense_Mutation_p.A739S	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	739							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						ACAGTTTAATGCCGAAGATAT	0.343000													21	35					3.6726e-16	3.44478e-15	0.000586117	1	0
LGR5	8549	broad.mit.edu	37	12	71977778	71977778	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:71977778G>C	ENST00000266674.5	+	18	2299	c.1988G>C	c.(1987-1989)gGg>gCg	p.G663A	LGR5_ENST00000536515.1_Missense_Mutation_p.G591A|LGR5_ENST00000540815.2_Missense_Mutation_p.G639A			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	663						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CTGGAGCGTGGGTTCTCTGTG	0.458000													20	95					0	0	0.00152264	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687802	27687802	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:27687802A>T	ENST00000438700.3	-	4	1842	c.1725T>A	c.(1723-1725)gaT>gaA	p.D575E		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	575					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						TTCCATGTTCATCTGGGACAG	0.388000													12	42					0	0	0.00136819	0	0
FRMD1	79981	broad.mit.edu	37	6	168479735	168479735	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:168479735G>T	ENST00000283309.6	-	1	104	c.40C>A	c.(40-42)Cgg>Agg	p.R14R		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	14						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGGTTTGTCCGGGCGGGGTCT	0.662000													5	17					1.76689e-08	1.33583e-07	0.000442599	1	0
GRM4	2914	broad.mit.edu	37	6	34101066	34101066	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:34101066G>T	ENST00000374181.3	-	1	377	c.208C>A	c.(208-210)Ctt>Att	p.L70I	GRM4_ENST00000538487.1_Missense_Mutation_p.L70I|GRM4_ENST00000374177.3_Intron	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	70					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TCCTTCTTAAGTTCTCCACAG	0.607000													10	15					3.86212e-05	0.000274257	0.000673444	1	0
ZRSR1	7310	broad.mit.edu	37	5	112228179	112228179	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:112228179G>A	ENST00000391338.1	+	1	867	c.843G>A	c.(841-843)tcG>tcA	p.S281S	REEP5_ENST00000513339.1_Intron|REEP5_ENST00000545426.1_3'UTR|REEP5_ENST00000504247.1_Intron|REEP5_ENST00000379638.4_Intron|SRP19_ENST00000512790.1_3'UTR|REEP5_ENST00000474542.2_Intron	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						AGTACCAGTCGGAAGAAGAAT	0.498000													9	176					0	0	0.00136819	0	0
GRAMD4	23151	broad.mit.edu	37	22	47069608	47069608	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:47069608G>A	ENST00000406902.1	+	15	1494	c.1281G>A	c.(1279-1281)ccG>ccA	p.P427P	GRAMD4_ENST00000361034.3_Silent_p.P427P			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	427					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CCAGCGCACCGGCCGGCCTGG	0.627000													9	102					0	0	0.000274275	0	0
NOD2	64127	broad.mit.edu	37	16	50759412	50759412	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:50759412C>A	ENST00000300589.2	+	10	3000	c.2895C>A	c.(2893-2895)aaC>aaA	p.N965K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	965					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGGAGGAGAACCATCTCCAGG	0.423000													10	63					0.00136819	0.00926569	0.00136819	1	0
FAM151A	338094	broad.mit.edu	37	1	55075139	55075139	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:55075139G>T	ENST00000302250.2	-	8	1720	c.1560C>A	c.(1558-1560)agC>agA	p.S520R	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000371316.3_Intron|ACOT11_ENST00000343744.2_3'UTR|FAM151A_ENST00000371304.2_Missense_Mutation_p.S333R	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	520						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTCCAGCTGTGCTGTGGCCCA	0.627000													16	70					1.00905e-13	9.1703e-13	0.00121646	1	0
KCNA4	3739	broad.mit.edu	37	11	30032722	30032722	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:30032722C>T	ENST00000328224.6	-	2	2737	c.1504G>A	c.(1504-1506)Gat>Aat	p.D502N		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	502						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GTAGGTTCATCCGCCTCTGCA	0.517000													9	49					0	0	0.000442599	0	0
LPHN2	23266	broad.mit.edu	37	1	82409266	82409266	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:82409266G>T	ENST00000370728.1	+	8	1656	c.1011G>T	c.(1009-1011)aaG>aaT	p.K337N	LPHN2_ENST00000370723.1_Missense_Mutation_p.K337N|LPHN2_ENST00000319517.6_Missense_Mutation_p.K337N|LPHN2_ENST00000370730.1_Missense_Mutation_p.K337N|LPHN2_ENST00000370725.1_Missense_Mutation_p.K337N|LPHN2_ENST00000394879.1_Missense_Mutation_p.K337N|LPHN2_ENST00000370717.2_Missense_Mutation_p.K337N|LPHN2_ENST00000370715.1_Missense_Mutation_p.K337N|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370721.1_Missense_Mutation_p.K341N|LPHN2_ENST00000359929.3_Missense_Mutation_p.K337N|LPHN2_ENST00000271029.4_Missense_Mutation_p.K337N|LPHN2_ENST00000370713.1_Missense_Mutation_p.K337N|LPHN2_ENST00000335786.5_Missense_Mutation_p.K337N|LPHN2_ENST00000370727.1_Missense_Mutation_p.K337N			O95490	LPHN2_HUMAN	latrophilin 2	337	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AAACAGGCAAGAACTCAATTG	0.393000													30	132					2.42023e-17	2.33247e-16	0.00058488	1	0
SLCO5A1	81796	broad.mit.edu	37	8	70594561	70594561	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:70594561G>T	ENST00000260126.3	-	7	2346	c.1640C>A	c.(1639-1641)cCc>cAc	p.P547H	SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P492H|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P547H	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	547						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ATTCCTATGGGGCATGGTGAG	0.393000													19	110					9.86323e-18	9.66486e-17	0.000586117	1	0
ZNF582	147948	broad.mit.edu	37	19	56895292	56895292	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:56895292T>A	ENST00000301310.4	-	5	1652	c.1494A>T	c.(1492-1494)agA>agT	p.R498S	ZNF582_ENST00000586929.1_Missense_Mutation_p.R498S	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		ACATAAATTCTCTGATGATTA	0.393000													13	103					0	0	0.000308642	0	0
CAGE1	285782	broad.mit.edu	37	6	7370188	7370188	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:7370188A>G	ENST00000502583.1	-	6	2421	c.1857T>C	c.(1855-1857)agT>agC	p.S619S	CAGE1_ENST00000379918.4_Silent_p.S619S|CAGE1_ENST00000512086.1_Silent_p.S619S|CAGE1_ENST00000296742.7_Silent_p.S483S|CAGE1_ENST00000338150.4_Silent_p.S619S	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	619										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					GAGCCAGAAGACTGTGCATTT	0.428000													8	14					0	0	0.000978159	0	0
COL14A1	7373	broad.mit.edu	37	8	121170434	121170434	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:121170434G>C	ENST00000297848.3	+	3	424	c.154G>C	c.(154-156)Gct>Cct	p.A52P	COL14A1_ENST00000309791.4_Missense_Mutation_p.A52P|COL14A1_ENST00000537875.1_Missense_Mutation_p.A52P|COL14A1_ENST00000247781.3_Missense_Mutation_p.A52P|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	52	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTCATGGAAGGCTCCAAGAGG	0.358000													8	55					0	0	0.000157383	0	0
SMPD3	55512	broad.mit.edu	37	16	68397446	68397446	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:68397446C>T	ENST00000219334.5	-	7	2265	c.1662G>A	c.(1660-1662)acG>acA	p.T554T	SMPD3_ENST00000568373.1_Silent_p.T554T|SMPD3_ENST00000563226.1_Silent_p.T546T	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	554					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	ACAGGCCGTTCGTGTCCAGCA	0.657000													6	62					0	0	0.000157383	0	0
KCNH8	131096	broad.mit.edu	37	3	19491633	19491633	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:19491633G>T	ENST00000328405.2	+	9	1677	c.1411G>T	c.(1411-1413)Gca>Tca	p.A471S	KCNH8_ENST00000537696.1_Missense_Mutation_p.A140S	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	471						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						AAACGTGACAGCAATCATACA	0.438000													19	32					5.35356e-11	4.4715e-10	0.000375601	1	0
PLXDC2	84898	broad.mit.edu	37	10	20357100	20357100	+	Splice_Site	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:20357100G>T	ENST00000377252.3	+	4	1314	c.471_splice	c.e4-1	p.R158_splice	PLXDC2_ENST00000377242.3_Splice_Site_p.R109_splice|PLXDC2_ENST00000377238.2_3'UTR	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	158						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						TCTTTGCAGAGAGTGAATCTG	0.383000													12	44					4.14922e-12	3.58509e-11	0.000422831	1	0
NEBL	10529	broad.mit.edu	37	10	21461326	21461326	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:21461326C>T	ENST00000417816.2	-	2	503	c.150G>A	c.(148-150)aaG>aaA	p.K50K	NEBL_ENST00000464278.1_5'UTR	NM_001173484.1|NM_213569.2	NP_001166955.1|NP_998734.1	O76041	NEBL_HUMAN	nebulette	712					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TACAATAGGGCTTCTTTTCAT	0.433000													10	35					0	0	0.000978159	0	0
REG3A	5068	broad.mit.edu	37	2	79384822	79384822	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:79384822G>A	ENST00000393878.1	-	4	590	c.336C>T	c.(334-336)ggC>ggT	p.G112G	REG3A_ENST00000409839.3_Silent_p.G112G|REG3A_ENST00000305165.2_Silent_p.G112G	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	112	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						TGGGCTCGGTGCCCTGTAGAG	0.542000													30	49					0	0	0.00111076	0	0
UGT2B15	7366	broad.mit.edu	37	4	69512953	69512953	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:69512953G>T	ENST00000338206.5	-	6	1471	c.1462C>A	c.(1462-1464)Cag>Aag	p.Q488K		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	488					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GAGTGGTACTGGATCCAGGTG	0.488000													23	106					1.66031e-10	1.3545e-09	0.000586117	1	0
TOM1	10043	broad.mit.edu	37	22	35742927	35742927	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:35742927A>G	ENST00000411850.1	+	14	1414	c.1289A>G	c.(1288-1290)aAt>aGt	p.N430S	TOM1_ENST00000425375.1_Missense_Mutation_p.N385S|TOM1_ENST00000449058.2_Missense_Mutation_p.N430S|TOM1_ENST00000382034.5_3'UTR|TOM1_ENST00000436462.2_Missense_Mutation_p.N392S|TOM1_ENST00000447733.1_Missense_Mutation_p.N397S	NM_001135732.1	NP_001129204.1	O60784	TOM1_HUMAN	target of myb1 (chicken)	430					endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			NS(1)|breast(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)	19						TCCCAGGGTAATGATGCGGAA	0.662000													50	55					0	0	0.000781405	0	0
CDH10	1008	broad.mit.edu	37	5	24487802	24487802	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:24487802A>G	ENST00000264463.4	-	12	2844	c.2337T>C	c.(2335-2337)taT>taC	p.Y779Y	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	779					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CCCCACCACCATACATTTCTG	0.408000										HNSCC(23;0.051)			6	190					0	0	8.12818e-05	0	0
PRKG2	5593	broad.mit.edu	37	4	82125782	82125782	+	Silent	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:82125782A>T	ENST00000395578.1	-	2	536	c.420T>A	c.(418-420)ccT>ccA	p.P140P	PRKG2_ENST00000264399.1_Silent_p.P140P|PRKG2_ENST00000418486.2_Silent_p.P140P			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	140					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						AGGAAAATTCAGGGGGTTTGT	0.468000													111	251					0	0	0.000781405	0	0
TUBA1C	84790	broad.mit.edu	37	12	49663442	49663442	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:49663442G>T	ENST00000301072.6	+	2	473	c.198G>T	c.(196-198)gtG>gtT	p.V66V	TUBA1C_ENST00000541364.1_Silent_p.V136V|TUBA1C_ENST00000549183.1_Silent_p.V66V|RP11-161H23.5_ENST00000550468.2_RNA	NM_032704.3	NP_116093.1	Q9BQE3	TBA1C_HUMAN	tubulin, alpha 1c	66					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)	13						CCCGGGCAGTGTTTGTAGACT	0.562000													31	116					1.82762e-36	2.00352e-35	0.00128727	1	0
CABIN1	23523	broad.mit.edu	37	22	24574118	24574118	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:24574118C>T	ENST00000398319.2	+	37	7002	c.6617C>T	c.(6616-6618)tCg>tTg	p.S2206L	CABIN1_ENST00000405822.2_Missense_Mutation_p.S2127L|CABIN1_ENST00000337989.7_Missense_Mutation_p.S576L|CABIN1_ENST00000263119.5_Missense_Mutation_p.S2206L	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2206					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CAGGAGTCCTCGCTGGAGAGC	0.637000													13	53					0	0	0.000308642	0	0
CNTN3	5067	broad.mit.edu	37	3	74347306	74347306	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:74347306C>G	ENST00000263665.6	-	17	2230	c.2203G>C	c.(2203-2205)Ggg>Cgg	p.G735R		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	735	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACAACATACCCAAAACCTTCA	0.458000													17	23					0	0	0.00152264	0	0
SLC5A1	6523	broad.mit.edu	37	22	32500780	32500780	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:32500780G>A	ENST00000266088.4	+	14	1923	c.1673G>A	c.(1672-1674)cGt>cAt	p.R558H	SLC5A1_ENST00000543737.1_Missense_Mutation_p.R431H	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	558					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						CAGCTCTACCGTCTGTGTTGG	0.502000													11	54					0	0	0.00136819	0	0
NYAP2	57624	broad.mit.edu	37	2	226447663	226447663	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:226447663G>A	ENST00000272907.6	+	4	1943	c.1530G>A	c.(1528-1530)ccG>ccA	p.P510P	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	510																	CCACGAGCCCGCTGGAGGAGC	0.682000													4	22					0	0	0.00024832	0	0
WDR96	80217	broad.mit.edu	37	10	105903272	105903272	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr10:105903272T>C	ENST00000357060.3	-	32	4185	c.4070A>G	c.(4069-4071)aAt>aGt	p.N1357S	WDR96_ENST00000428666.1_Missense_Mutation_p.N1329S	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1357										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTTACTAATATTGTCCAACTC	0.418000													4	82					0	0	0.000602214	0	0
KDM4D	55693	broad.mit.edu	37	11	94730894	94730894	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:94730894G>T	ENST00000335080.5	+	3	1190	c.358G>T	c.(358-360)Gat>Tat	p.D120Y	KDM4D_ENST00000536741.1_Missense_Mutation_p.D120Y	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	120					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GAATTTCGAAGATTTGGAGCG	0.393000													40	203					1.00776e-21	1.04592e-20	0.000781405	1	0
SLC25A52	147407	broad.mit.edu	37	18	29340057	29340057	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr18:29340057A>C	ENST00000269205.5	-	1	786	c.598T>G	c.(598-600)Ttt>Gtt	p.F200V	SLC25A52_ENST00000579441.2_Missense_Mutation_p.F190V	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	190					transport	integral to membrane|mitochondrial inner membrane											AGGCCGAAAAACAAGACATTG	0.473000													7	70					0	0	0.000978159	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139456	90139456	+	RNA	SNP	T	T	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:90139456T>G	ENST00000492446.1	+	0	254																											GCATCCAGTTTGCAAAGTGGG	0.507000													10	127					0	0	0.00185496	0	0
KCNA1	3736	broad.mit.edu	37	12	5021140	5021140	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:5021140C>G	ENST00000382545.3	+	2	1703	c.596C>G	c.(595-597)aCg>aGg	p.T199R	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	199					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AAGGACTTCACGGGCACCGTC	0.542000													8	49					0	0	0.000274275	0	0
MYO7A	4647	broad.mit.edu	37	11	76877182	76877182	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:76877182C>G	ENST00000409709.3	+	15	2043	c.1771C>G	c.(1771-1773)Cag>Gag	p.Q591E	MYO7A_ENST00000458637.2_Missense_Mutation_p.Q591E|MYO7A_ENST00000409619.2_Missense_Mutation_p.Q580E|MYO7A_ENST00000409893.1_Missense_Mutation_p.Q591E	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	591	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GTTCATCAAGCAGATCTTCCA	0.587000													43	31					0	0	0.000781405	0	0
BTBD10	84280	broad.mit.edu	37	11	13443241	13443241	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:13443241C>G	ENST00000278174.5	-	3	491	c.246G>C	c.(244-246)caG>caC	p.Q82H	BTBD10_ENST00000530907.1_Missense_Mutation_p.Q90H|BTBD10_ENST00000528120.1_Missense_Mutation_p.Q34H|BTBD10_ENST00000532261.1_5'UTR	NM_032320.5	NP_115696.2	Q9BSF8	BTBDA_HUMAN	BTB (POZ) domain containing 10	82						nucleus				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|prostate(1)	20				Epithelial(150;0.0214)		AAGGAGTGAGCTGAGACTCCG	0.418000													4	55					0	0	0.000602214	0	0
ACTRT3	84517	broad.mit.edu	37	3	169485598	169485598	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:169485598G>T	ENST00000330368.2	-	2	1115	c.741C>A	c.(739-741)ctC>ctA	p.L247L		NM_032487.4	NP_115876.3	Q9BYD9	ARPM1_HUMAN	actin-related protein T3	247						cytoplasm|cytoskeleton											GCTGGTCATGGAGCTGGATGA	0.463000													23	75					6.44725e-10	5.16369e-09	0.000295444	1	0
NAV1	89796	broad.mit.edu	37	1	201779821	201779821	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:201779821C>A	ENST00000367296.4	+	24	5152	c.4732C>A	c.(4732-4734)Cgc>Agc	p.R1578S	NAV1_ENST00000367302.1_Missense_Mutation_p.R1531S|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367297.4_Missense_Mutation_p.R1570S|NAV1_ENST00000295624.6_Missense_Mutation_p.R1575S|NAV1_ENST00000367300.3_Missense_Mutation_p.R1518S|NAV1_ENST00000367295.1_Missense_Mutation_p.R1184S	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1578					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CCTGGTGGAGCGCTCTGGCCG	0.642000													8	65					0.000978159	0.00664996	0.000978159	1	0
C2orf71	388939	broad.mit.edu	37	2	29296593	29296593	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:29296593G>C	ENST00000331664.5	-	1	534	c.535C>G	c.(535-537)Cct>Gct	p.P179A		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	179					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTTACCAGAGGCTCCGGGAAG	0.532000													11	41					0	0	0.00136819	0	0
ACAN	176	broad.mit.edu	37	15	89401784	89401784	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:89401784G>T	ENST00000439576.2	+	12	6342	c.5968G>T	c.(5968-5970)Ggg>Tgg	p.G1990W	ACAN_ENST00000561243.1_Missense_Mutation_p.G1990W|ACAN_ENST00000352105.7_Missense_Mutation_p.G1990W|ACAN_ENST00000559004.1_Missense_Mutation_p.G1990W	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1990					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTGCAGTCCGGGCTGATAGA	0.532000													27	37					8.73648e-17	8.32814e-16	0.000814825	1	0
CKM	1158	broad.mit.edu	37	19	45810857	45810857	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:45810857G>A	ENST00000221476.3	-	7	1003	c.829C>T	c.(829-831)Ctg>Ttg	p.L277L		NM_001824.4	NP_001815.2	P06732	KCRM_HUMAN	creatine kinase, muscle	277	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(3)|prostate(2)|skin(2)	17		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	ACGTAGCCCAGGTGCTGGTTC	0.612000													6	29					0	0	0.00116845	0	0
PCLO	27445	broad.mit.edu	37	7	82390736	82390736	+	Silent	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:82390736T>A	ENST00000333891.8	-	23	15418	c.15081A>T	c.(15079-15081)atA>atT	p.I5027I		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4950	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAATTTCAACTATTAGTTGTT	0.303000													4	9					0	0	0.00024832	0	0
MYH2	4620	broad.mit.edu	37	17	10429057	10429057	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:10429057T>G	ENST00000245503.5	-	31	4708	c.4324A>C	c.(4324-4326)Aat>Cat	p.N1442H	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.N1442H|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1442					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CAGGCGGCATTTGTCCTCTCC	0.488000													5	113					0	0	0.000157383	0	0
ZIC4	84107	broad.mit.edu	37	3	147120593	147120593	+	Translation_Start_Site	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:147120593T>A	ENST00000383075.3	-	0	504				ZIC4_ENST00000484399.1_De_novo_Start_OutOfFrame|ZIC4_ENST00000491672.1_De_novo_Start_OutOfFrame|ZIC4_ENST00000525172.2_Missense_Mutation_p.S48C|ZIC4_ENST00000425731.3_Missense_Mutation_p.S36C|ZIC4_ENST00000473123.1_De_novo_Start_OutOfFrame	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4							nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						ATTTTCTGACTTTGAGCCTGT	0.383000													69	67					0	0	0.000781405	0	0
C16orf89	146556	broad.mit.edu	37	16	5115926	5115926	+	Translation_Start_Site	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:5115926C>T	ENST00000315997.5	-	0	185				C16orf89_ENST00000350219.4_Missense_Mutation_p.S33N|ALG1_ENST00000588623.1_Intron|C16orf89_ENST00000472572.3_De_novo_Start_OutOfFrame|C16orf89_ENST00000474471.3_De_novo_Start_OutOfFrame|C16orf89_ENST00000422873.1_Missense_Mutation_p.S33N	NM_152459.4	NP_689672.4	Q6UX73	CP089_HUMAN	chromosome 16 open reading frame 89							extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	12						CCTCTGCTCACTGCTGGTCAC	0.657000													3	7					0	0	6.4e-05	0	0
ZNF718	255403	broad.mit.edu	37	4	155785	155785	+	RNA	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:155785A>T	ENST00000510175.1	+	0	1220							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		CAGTCCTCACACTTGAATAAA	0.348000													10	11					0	0	0.000673444	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563087	140563087	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:140563087G>C	ENST00000361016.2	+	1	2108	c.953G>C	c.(952-954)cGc>cCc	p.R318P		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		318	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TATGAAGTGCGCATCAAAGCC	0.473000													10	68					0	0	0.000442599	0	0
SND1	27044	broad.mit.edu	37	7	127342493	127342493	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:127342493C>G	ENST00000354725.3	+	6	788	c.594C>G	c.(592-594)atC>atG	p.I198M		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	198	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						ACACAGCTATCATCGAGCATG	0.488000													11	115					0	0	0.00185496	0	0
MROH5	389690	broad.mit.edu	37	8	142490535	142490535	+	RNA	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:142490535G>T	ENST00000430863.1	-	0	844					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GAACGGGACTGACTTGATGGC	0.632000													11	45					1.5739e-10	1.29001e-09	0.000422831	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577018	33577018	+	Missense_Mutation	SNP	G	G	T	rs147729472		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:33577018G>T	ENST00000504830.1	-	19	3448	c.3113C>A	c.(3112-3114)cCt>cAt	p.P1038H	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P953H	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1038	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CATAGACTCAGGCCCTGTGGG	0.532000										HNSCC(64;0.19)			11	59					2.68362e-12	2.33023e-11	0.00136819	1	0
KRT74	121391	broad.mit.edu	37	12	52962104	52962104	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:52962104C>T	ENST00000549343.1	-	8	1284	c.1246G>A	c.(1246-1248)Gcc>Acc	p.A416T	KRT74_ENST00000305620.2_Missense_Mutation_p.A402T			Q7RTS7	K2C74_HUMAN	keratin 74	402	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		TCCAGCTTGGCCTGGGCATCC	0.637000													18	45					0	0	0.000295444	0	0
MUC16	94025	broad.mit.edu	37	19	9046316	9046316	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:9046316G>T	ENST00000397910.4	-	5	35518	c.35315C>A	c.(35314-35316)gCc>gAc	p.A11772D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11774	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTCAATAAGGCTGTGGTCTC	0.473000													12	22					0.00010058	0.000702857	0.00136819	1	0
IL17A	3605	broad.mit.edu	37	6	52053914	52053914	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:52053914G>T	ENST00000340057.1	+	3	337	c.292G>T	c.(292-294)Ggc>Tgc	p.G98C		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	98					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					CCGCCACTTGGGCTGCATCAA	0.562000													18	24					1.78486e-19	1.79922e-18	0.000958276	1	0
TRMT5	57570	broad.mit.edu	37	14	61446565	61446565	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:61446565C>T	ENST00000261249.6	-	2	435	c.51G>A	c.(49-51)ctG>ctA	p.L17L	RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	17						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		TTTCCAGTTTCAGAAATCTTC	0.348000													12	77					0	0	0.000219431	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38173510	38173510	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:38173510C>T	ENST00000317025.8	-	10	2423	c.1906G>A	c.(1906-1908)Gcc>Acc	p.A636T	WHSC1L1_ENST00000433384.2_Missense_Mutation_p.A636T|WHSC1L1_ENST00000527502.1_Missense_Mutation_p.A636T	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	636					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TCAGTTGAGGCGCGACTCCTT	0.408000			T	NUP98	AML								18	90					0	0	0.00152264	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146308	70146308	+	Silent	SNP	C	C	A	rs150706540	byFrequency	TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:70146308C>A	ENST00000335568.5	+	1	92	c.90C>A	c.(88-90)acC>acA	p.T30T	UGT2B28_ENST00000511240.1_Silent_p.T30T	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	30					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	TGGTGTGGACCGGTGAATACA	0.463000													36	215					2.75727e-19	2.74787e-18	0.000953801	1	0
MYH1	4619	broad.mit.edu	37	17	10404775	10404775	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:10404775C>A	ENST00000226207.5	-	27	3484	c.3390G>T	c.(3388-3390)cgG>cgT	p.R1130R	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1130						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CCCGGGAGGCCCGCTCTGCCT	0.572000													33	39					4.62619e-21	4.74523e-20	0.000814825	1	0
WNK2	65268	broad.mit.edu	37	9	96021231	96021231	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:96021231G>A	ENST00000297954.4	+	11	2401	c.2401G>A	c.(2401-2403)Gtg>Atg	p.V801M	WNK2_ENST00000395477.2_Missense_Mutation_p.V801M|WNK2_ENST00000427277.2_Missense_Mutation_p.V413M|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.V413M|WNK2_ENST00000395475.2_Missense_Mutation_p.V735M			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	801					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GATTCCTGTTGTGCCCCCCAT	0.647000													12	47					0	0	0.00185496	0	0
TRIM48	79097	broad.mit.edu	37	11	55035844	55035844	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:55035844T>C	ENST00000417545.2	+	4	660	c.574T>C	c.(574-576)Tac>Cac	p.Y192H		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	176						intracellular	zinc ion binding	p.Y192H(11)|p.Y176H(11)		endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AGACATATTATACAGGTGAGT	0.338000													5	77					0	0	0.000602214	0	0
MAP1B	4131	broad.mit.edu	37	5	71494034	71494034	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:71494034T>C	ENST00000296755.7	+	5	5150	c.4852T>C	c.(4852-4854)Tca>Cca	p.S1618P		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1618						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCGATGTCAATTTCTCC	0.438000													13	81					0	0	0.00074312	0	0
PALLD	23022	broad.mit.edu	37	4	169602547	169602547	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:169602547A>G	ENST00000335742.7	+	4	1363	c.6A>G	c.(4-6)ccA>ccG	p.P2P	PALLD_ENST00000505667.1_Silent_p.P384P|PALLD_ENST00000261509.6_Silent_p.P384P|PALLD_ENST00000512127.1_Silent_p.P2P|PALLD_ENST00000333488.4_Silent_p.P261P			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	384					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GAGCTATGCCACAGTAAGTGC	0.383000									Pancreatic Cancer, Familial Clustering of				23	70					0	0	0.000586117	0	0
KATNB1	10300	broad.mit.edu	37	16	57778336	57778336	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:57778336A>G	ENST00000379661.3	+	4	594	c.202A>G	c.(202-204)Agc>Ggc	p.S68G		NM_005886.2	NP_005877.2	Q9BVA0	KTNB1_HUMAN	katanin p80 (WD repeat containing) subunit B 1	68	Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_neural(199;0.223)				CCCAGTGGAGAGCGTCCGCCT	0.637000													6	44					0	0	0.00116845	0	0
LRRC49	54839	broad.mit.edu	37	15	71229102	71229102	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:71229102A>T	ENST00000260382.5	+	8	974	c.714A>T	c.(712-714)agA>agT	p.R238S	LRRC49_ENST00000560691.1_5'UTR|LRRC49_ENST00000544974.2_Missense_Mutation_p.R228S|LRRC49_ENST00000443425.2_Missense_Mutation_p.R194S|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000560369.1_Missense_Mutation_p.R243S|LRRC49_ENST00000560158.2_5'UTR	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	238						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						TCTTCCAGAGAGATGTGGATA	0.303000													10	43					0	0	0.000673444	0	0
TOR1B	27348	broad.mit.edu	37	9	132566479	132566479	+	Silent	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:132566479C>G	ENST00000259339.2	+	2	387	c.327C>G	c.(325-327)ggC>ggG	p.G109G	TOR1B_ENST00000486372.1_3'UTR	NM_014506.1	NP_055321.1	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B)	109					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)	12		Ovarian(14;0.0586)				CCTTACACGGCTGGGCTGGCA	0.463000													5	52					0	0	0.00116845	0	0
PCNX	22990	broad.mit.edu	37	14	71556018	71556018	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:71556018G>A	ENST00000304743.2	+	30	5994	c.5548G>A	c.(5548-5550)Gta>Ata	p.V1850I	PCNX_ENST00000439984.3_Missense_Mutation_p.V1739I|PCNX_ENST00000238570.5_Missense_Mutation_p.V1778I	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1850						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GCTAAGAAAAGTAGTAGTCCC	0.373000													16	76					0	0	0.000566183	0	0
LRP1B	53353	broad.mit.edu	37	2	141946128	141946128	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:141946128C>A	ENST00000389484.3	-	7	1846	c.875G>T	c.(874-876)tGg>tTg	p.W292L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	292					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCGAGTGAGCCAGTCAATCGC	0.398000										TSP Lung(27;0.18)			9	40					0.00010058	0.000702857	0.00136819	1	0
SPTBN4	57731	broad.mit.edu	37	19	41009787	41009787	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:41009787C>T	ENST00000352632.3	+	12	1499	c.1413C>T	c.(1411-1413)caC>caT	p.H471H	SPTBN4_ENST00000595535.1_Silent_p.H471H|SPTBN4_ENST00000344104.3_Silent_p.H471H|SPTBN4_ENST00000598249.1_Silent_p.H471H|SPTBN4_ENST00000338932.3_Silent_p.H471H			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	471					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAAGAAACACGAAGCGATCG	0.622000													5	31					0	0	8.12818e-05	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50186235	50186235	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:50186235G>A	ENST00000335999.6	-	12	3987	c.3786C>T	c.(3784-3786)acC>acT	p.T1262T		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1258	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						TCACCATGGGGGTCCTGGGCA	0.607000													3	12					0	0	6.4e-05	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988740	154988740	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:154988740G>T	ENST00000368426.3	+	4	1336	c.1199G>T	c.(1198-1200)cGc>cTc	p.R400L	ZBTB7B_ENST00000292176.2_Missense_Mutation_p.R400L|ZBTB7B_ENST00000535420.1_Missense_Mutation_p.R400L|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.R434L	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	400					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACGGGAGAGCGCCCCTACTCA	0.637000													18	104					8.28177e-16	7.68583e-15	0.000958276	1	0
ATP6AP1	537	broad.mit.edu	37	X	153664066	153664066	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:153664066C>T	ENST00000369762.2	+	10	1303	c.1242C>T	c.(1240-1242)taC>taT	p.Y414Y		NM_001183.4	NP_001174.2	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1	414					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(5)	14	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGTTCTCCTACGCCAGCGACT	0.577000													9	112					0	0	0.000442599	0	0
FNDC8	54752	broad.mit.edu	37	17	33454312	33454312	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:33454312T>A	ENST00000158009.5	+	2	576	c.461T>A	c.(460-462)cTg>cAg	p.L154Q		NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	154										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		AGGGGCCTGCTGGACCTTGAC	0.582000													46	62					0	0	0.000781405	0	0
KIF17	57576	broad.mit.edu	37	1	21009225	21009225	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:21009225C>A	ENST00000247986.2	-	11	2694	c.2384G>T	c.(2383-2385)tGg>tTg	p.W795L	KIF17_ENST00000375044.1_Missense_Mutation_p.W695L|KIF17_ENST00000400463.3_Missense_Mutation_p.W795L|KIF17_ENST00000490034.1_5'UTR			Q9P2E2	KIF17_HUMAN	kinesin family member 17	795					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		AAGCAGCACCCAGTCCCCGCT	0.622000													12	38					2.61681e-11	2.21734e-10	0.000219431	1	0
UGGT1	56886	broad.mit.edu	37	2	128861574	128861574	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:128861574C>A	ENST00000375990.3	+	3	594	c.191C>A	c.(190-192)tCa>tAa	p.S64*	UGGT1_ENST00000259253.6_Nonsense_Mutation_p.S88*			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	88					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AATATTGGATCATCAGATCAT	0.338000													16	75					7.45023e-12	6.37449e-11	0.00152264	1	0
P2RY8	286530	broad.mit.edu	37	X	1584494	1584494	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:1584494T>A	ENST00000381297.4	-	2	1168	c.958A>T	c.(958-960)Acg>Tcg	p.T320S		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	320						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCGCGGCGCGTGTCCAGGGTG	0.667000			T	CRLF2	"""B-ALL, Downs associated ALL"""								8	51					0	0	0.000442599	0	0
ZFP2	80108	broad.mit.edu	37	5	178359519	178359519	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:178359519G>C	ENST00000361362.2	+	5	1735	c.1205G>C	c.(1204-1206)aGa>aCa	p.R402T	ZFP2_ENST00000523286.1_Missense_Mutation_p.R402T|ZFP2_ENST00000503510.2_Missense_Mutation_p.R402T|ZFP2_ENST00000520301.1_Missense_Mutation_p.R402T	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GAACATCAAAGAATTCATACT	0.418000													6	49					0	0	0.00116845	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755817	140755817	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:140755817C>A	ENST00000517434.1	+	1	2167	c.2167C>A	c.(2167-2169)Cgc>Agc	p.R723S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACAAGTCACGCCTGCTGCA	0.647000													27	59					4.72057e-08	3.53841e-07	0.000586117	1	0
NUBPL	80224	broad.mit.edu	37	14	32142771	32142771	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:32142771G>T	ENST00000281081.7	+	6	549	c.504G>T	c.(502-504)ttG>ttT	p.L168F	NUBPL_ENST00000536705.1_Missense_Mutation_p.L72F	NM_001201573.1|NM_001201574.1|NM_025152.2	NP_001188502.1|NP_001188503.1|NP_079428.2	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	168					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding			endometrium(1)|lung(2)|prostate(1)|skin(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		TTGAGAAATTGTTGAGGCAGG	0.358000													10	58					6.40141e-05	0.000452745	0.000978159	1	0
DENND1A	57706	broad.mit.edu	37	9	126165745	126165745	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr9:126165745C>A	ENST00000373624.2	-	20	1714	c.1513G>T	c.(1513-1515)Gtt>Ttt	p.V505F	DENND1A_ENST00000542603.1_Missense_Mutation_p.V247F|DENND1A_ENST00000373620.3_Missense_Mutation_p.V505F|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394215.2_Missense_Mutation_p.V475F|DENND1A_ENST00000394219.3_Missense_Mutation_p.V473F	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	505						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GGTCTCTTAACAACATGTGGA	0.542000													9	38					4.3838e-07	3.21723e-06	0.00185496	1	0
MXRA5	25878	broad.mit.edu	37	X	3235282	3235282	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:3235282C>A	ENST00000217939.6	-	6	6594	c.6440G>T	c.(6439-6441)cGc>cTc	p.R2147L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2147	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCCGTGATGCGCGCGTTGGC	0.706000													10	5					4.3838e-07	3.21723e-06	0.00185496	1	0
RFFL	117584	broad.mit.edu	37	17	33348712	33348712	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:33348712C>A	ENST00000315249.7	-	3	491	c.269G>T	c.(268-270)cGg>cTg	p.R90L	RFFL_ENST00000447669.2_Missense_Mutation_p.R90L|RFFL_ENST00000415395.2_Missense_Mutation_p.R90L|RFFL_ENST00000413582.2_Missense_Mutation_p.R90L|RFFL_ENST00000394597.2_Missense_Mutation_p.R90L|RFFL_ENST00000378516.2_Missense_Mutation_p.R90L|RFFL_ENST00000268850.7_Missense_Mutation_p.R90L|RFFL_ENST00000584655.1_Missense_Mutation_p.R90L|RAD51L3-RFFL_ENST00000593039.1_Intron			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	90					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGCTCGAAACCGTTGGCAGAG	0.512000													31	43					2.04263e-09	1.59235e-08	0.000814825	1	0
HOXB1	3211	broad.mit.edu	37	17	46607047	46607047	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:46607047C>A	ENST00000239174.6	-	2	860	c.768G>T	c.(766-768)atG>atT	p.M256I	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	256						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCTTCTGCTTCATTCGTCGGT	0.597000													56	76					1.12612e-26	1.1971e-25	0.000781405	1	0
TENM2	57451	broad.mit.edu	37	5	167645264	167645264	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:167645264C>T	ENST00000519204.1	+	22	4123	c.4005C>T	c.(4003-4005)tgC>tgT	p.C1335C	TENM2_ENST00000520394.1_Silent_p.C1217C|TENM2_ENST00000545108.1_Silent_p.C1455C|TENM2_ENST00000403607.2_Silent_p.C1280C|TENM2_ENST00000518659.1_Silent_p.C1456C					teneurin transmembrane protein 2																		CCATGCACTGCCAAGTTCCTG	0.507000													89	153					0	0	0.000781405	0	0
BCL11A	53335	broad.mit.edu	37	2	60773316	60773316	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:60773316C>A	ENST00000335712.6	-	2	402	c.175G>T	c.(175-177)Gac>Tac	p.D59Y	BCL11A_ENST00000358510.4_Missense_Mutation_p.D59Y|BCL11A_ENST00000538214.1_Missense_Mutation_p.D59Y|BCL11A_ENST00000359629.5_Missense_Mutation_p.D59Y|BCL11A_ENST00000356842.4_Missense_Mutation_p.D59Y|BCL11A_ENST00000537768.1_5'UTR	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	59	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ATAAGAATGTCCCCCAATGGG	0.502000			T	IGH@	B-CLL								19	43					5.03518e-11	4.2257e-10	0.000958276	1	0
MAG	4099	broad.mit.edu	37	19	35791158	35791158	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:35791158T>G	ENST00000361922.4	+	6	971	c.821T>G	c.(820-822)aTg>aGg	p.M274R	MAG_ENST00000537831.2_Missense_Mutation_p.M249R|MAG_ENST00000392213.3_Missense_Mutation_p.M274R	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	274	Ig-like C2-type 2.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTGACCTGGATGCGGGACGGG	0.687000													4	6					0	0	0.00024832	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62781405	62781405	+	RNA	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:62781405C>T	ENST00000582986.1	-	0	2445					NR_024386.1																						CTGGTACTTGCGTCAGCGAGC	0.617000													14	15					0	0	0.00121646	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185797	127185797	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:127185797A>T	ENST00000371124.3	-	1	585	c.389T>A	c.(388-390)tTc>tAc	p.F130Y		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	130						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						AGGCACACTGAAGGTCTCAAA	0.512000													88	64					0	0	0.000781405	0	0
F9	2158	broad.mit.edu	37	X	138644049	138644049	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:138644049G>C	ENST00000218099.2	+	8	1212	c.1205G>C	c.(1204-1206)gGa>gCa	p.G402A	F9_ENST00000394090.2_Missense_Mutation_p.G364A	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	402	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TTCCATGAAGGAGGTAGAGAT	0.453000													19	62					0	0	0.00121646	0	0
AGBL2	79841	broad.mit.edu	37	11	47711852	47711852	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:47711852G>A	ENST00000525123.1	-	10	1692	c.1407C>T	c.(1405-1407)tcC>tcT	p.S469S	AGBL2_ENST00000298861.4_Silent_p.S469S|AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000357610.3_Silent_p.S469S|AGBL2_ENST00000528244.1_Silent_p.S431S	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	469					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						TCATAACCCAGGAGCCATTAC	0.493000													27	68					0	0	0.000692331	0	0
TFPT	29844	broad.mit.edu	37	19	54611370	54611370	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:54611370G>A	ENST00000391757.1	-	5	586	c.568C>T	c.(568-570)Cag>Tag	p.Q190*	TFPT_ENST00000391759.1_Missense_Mutation_p.A202V|NDUFA3_ENST00000391764.3_Intron|TFPT_ENST00000391758.1_Missense_Mutation_p.A193V			P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner (in childhood Leukemia)	64					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding			large_intestine(2)|lung(2)	4	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					CGCATTTCCTGCTCGGCGTCC	0.701000			T	TCF3	pre-B ALL								17	61					0	0	0.00121646	0	0
PLK4	10733	broad.mit.edu	37	4	128804496	128804496	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:128804496A>G	ENST00000270861.5	+	3	480	c.206A>G	c.(205-207)cAt>cGt	p.H69R	PLK4_ENST00000513090.1_Intron|PLK4_ENST00000507249.1_Missense_Mutation_p.H69R|PLK4_ENST00000514379.1_Missense_Mutation_p.H28R|PLK4_ENST00000511942.1_3'UTR|PLK4_ENST00000515069.1_Missense_Mutation_p.H69R	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	69	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						CAATTGAAACATCCTTCTATC	0.313000													5	29					0	0	0.000602214	0	0
THSD7A	221981	broad.mit.edu	37	7	11630198	11630198	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:11630198G>A	ENST00000423059.3	-	4	1593	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	448	TSP type-1 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGGTTGCCGCGCCTCTTGTCC	0.557000										HNSCC(18;0.044)			13	26					0	0	0.000219431	0	0
GLI1	2735	broad.mit.edu	37	12	57863310	57863310	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:57863310G>T	ENST00000228682.2	+	11	1496	c.1405G>T	c.(1405-1407)Ggc>Tgc	p.G469C	GLI1_ENST00000543426.1_Missense_Mutation_p.G341C|GLI1_ENST00000546141.1_Missense_Mutation_p.G428C	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	469					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GGAAATGACTGGCAATGCAGG	0.602000													37	84					2.87052e-16	2.70693e-15	0.00111076	1	0
FRMD1	79981	broad.mit.edu	37	6	168479737	168479737	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:168479737G>T	ENST00000283309.6	-	1	102	c.38C>A	c.(37-39)gCc>gAc	p.A13D		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	13						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GTTTGTCCGGGCGGGGTCTAT	0.662000													5	17					1.76689e-08	1.33583e-07	0.000442599	1	0
OR6B3	150681	broad.mit.edu	37	2	240984909	240984909	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:240984909G>A	ENST00000319423.4	-	1	580	c.581C>T	c.(580-582)aCt>aTt	p.T194I		NM_173351.1	NP_775486.1	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B, member 3	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CAGCTCTGCAGTGGAGAAGTC	0.542000													4	51					0	0	0.000602214	0	0
ZZEF1	23140	broad.mit.edu	37	17	3981275	3981275	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:3981275A>T	ENST00000381638.2	-	19	3015	c.2891T>A	c.(2890-2892)tTc>tAc	p.F964Y	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	964							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GACGGACCAGAACAGGGAGAA	0.547000													6	43					0	0	0.000274275	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33122512	33122512	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr20:33122512C>T	ENST00000417166.2	+	3	193	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W	DYNLRB1_ENST00000480759.1_3'UTR|DYNLRB1_ENST00000374846.3_Missense_Mutation_p.R106W|DYNLRB1_ENST00000357156.2_Missense_Mutation_p.R54W			Q9NP97	DLRB1_HUMAN	dynein, light chain, roadblock-type 1	54					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity	p.R54W(1)		endometrium(1)|large_intestine(1)|lung(1)	3						CCTGAAGGCACGGAGCACCGT	0.547000													7	69					0	0	8.12818e-05	0	0
MAGEA11	4110	broad.mit.edu	37	X	148796188	148796188	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:148796188C>A	ENST00000355220.5	+	3	246	c.144C>A	c.(142-144)gcC>gcA	p.A48A	MAGEA11_ENST00000333104.4_Silent_p.A19A	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	48						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CAGAAAGAGCCCCATATGGTC	0.547000													18	11					2.89027e-11	2.43727e-10	0.000295444	1	0
FAM120B	84498	broad.mit.edu	37	6	170627219	170627219	+	Silent	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:170627219A>G	ENST00000476287.1	+	2	849	c.741A>G	c.(739-741)ttA>ttG	p.L247L	FAM120B_ENST00000540480.1_Silent_p.L259L|FAM120B_ENST00000252510.9_Intron|FAM120B_ENST00000537664.1_Silent_p.L270L	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	247					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		ACAAATGCTTATCGTCCTACA	0.443000													36	42					0	0	0.000781405	0	0
TP53	7157	broad.mit.edu	37	17	7577058	7577058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:7577058C>A	ENST00000420246.2	-	8	1012	c.880G>T	c.(880-882)Gag>Tag	p.E294*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E294*|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Nonsense_Mutation_p.E294*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E294*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E294*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	294	Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E294*(46)|p.E294fs*51(9)|p.K291fs*48(8)|p.0?(8)|p.E294K(3)|p.E294fs*12(3)|p.?(2)|p.E294Q(2)|p.L265_K305del41(1)|p.E294>*(1)|p.G293fs*1(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.E294fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGCTCCCCTTTCTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	29					1.64293e-13	1.48542e-12	0.00047179	1	0
STK3	6788	broad.mit.edu	37	8	99591989	99591989	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:99591989A>C	ENST00000523601.1	-	10	1334	c.935T>G	c.(934-936)gTa>gGa	p.V312G	STK3_ENST00000419617.2_Missense_Mutation_p.V284G	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	284	Poly-Glu.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		TAATATTGATACAGGTTTGGC	0.318000													18	30					0	0	0.000566183	0	0
CNTN5	53942	broad.mit.edu	37	11	100170004	100170004	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:100170004C>A	ENST00000524871.1	+	20	2786	c.2496C>A	c.(2494-2496)tcC>tcA	p.S832S	CNTN5_ENST00000279463.3_Silent_p.S832S|CNTN5_ENST00000528682.1_Silent_p.S832S|CNTN5_ENST00000418526.2_Silent_p.S758S|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Silent_p.S832S	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	832	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTGAAGCTTCCAAATTCATTT	0.423000													4	30					0.000602214	0.00411005	0.000602214	1	0
MYO7A	4647	broad.mit.edu	37	11	76903146	76903146	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:76903146G>T	ENST00000409709.3	+	31	4247	c.3975G>T	c.(3973-3975)caG>caT	p.Q1325H	MYO7A_ENST00000458637.2_Missense_Mutation_p.Q1325H|MYO7A_ENST00000409619.2_Missense_Mutation_p.Q1314H	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1325	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CCATCTCCCAGTGCGAGCAGT	0.662000											OREG0021258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	13					7.63091e-17	7.314e-16	0.00170553	1	0
CES1	1066	broad.mit.edu	37	16	55862829	55862829	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:55862829T>G	ENST00000422046.2	-	2	388	c.107A>C	c.(106-108)aAg>aCg	p.K36T	CES1_ENST00000361503.4_Missense_Mutation_p.K36T|CES1_ENST00000360526.3_Missense_Mutation_p.K37T			P23141	EST1_HUMAN	carboxylesterase 1	36					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GCTGACGAACTTCCCCAGCAC	0.557000													6	25					0	0	0.000274275	0	0
FRMD1	79981	broad.mit.edu	37	6	168479736	168479736	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:168479736G>T	ENST00000283309.6	-	1	103	c.39C>A	c.(37-39)gcC>gcA	p.A13A		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	13						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGTTTGTCCGGGCGGGGTCTA	0.662000													5	17					1.76689e-08	1.33583e-07	0.000442599	1	0
NEUROD4	58158	broad.mit.edu	37	12	55420935	55420935	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:55420935G>T	ENST00000242994.3	+	2	1090	c.712G>T	c.(712-714)Ggg>Tgg	p.G238W		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	238					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATCGTCCTTTGGGAGCCATCT	0.532000													27	39					5.45727e-16	5.09152e-15	0.001512	1	0
CR2	1380	broad.mit.edu	37	1	207643305	207643305	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:207643305G>A	ENST00000367057.3	+	6	1272	c.1083G>A	c.(1081-1083)atG>atA	p.M361I	CR2_ENST00000458541.2_Missense_Mutation_p.M361I|CR2_ENST00000367059.3_Missense_Mutation_p.M361I|CR2_ENST00000367058.3_Missense_Mutation_p.M361I	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	361	Sushi 6.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						GAGGCCGAATGGTATCTGGGC	0.498000													6	67					0	0	0.00116845	0	0
KCNB2	9312	broad.mit.edu	37	8	73480045	73480045	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:73480045G>T	ENST00000523207.1	+	2	664	c.76G>T	c.(76-78)Gac>Tac	p.D26Y		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	26					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGAGCCTGTGGACATTATCCG	0.547000													17	96					6.94344e-10	5.51077e-09	0.00074312	1	0
EDAR	10913	broad.mit.edu	37	2	109546685	109546685	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:109546685C>A	ENST00000409271.1	-	4	508	c.65G>T	c.(64-66)tGc>tTc	p.C22F	EDAR_ENST00000376651.1_Missense_Mutation_p.C22F|EDAR_ENST00000258443.2_Missense_Mutation_p.C22F			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	22					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TCGGGCTGAGCACATCAGAGA	0.582000													11	42					2.80697e-09	2.17851e-08	0.000978159	1	0
TMEM63A	9725	broad.mit.edu	37	1	226065270	226065270	+	Missense_Mutation	SNP	G	G	A	rs147318694		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:226065270G>A	ENST00000366835.3	-	3	281	c.11C>T	c.(10-12)tCc>tTc	p.S4F		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	4						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CAGGAACGGGGAGTCCATCAT	0.592000											OREG0014291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	35					0	0	0.00116845	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033441	37033441	+	Silent	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:37033441T>C	ENST00000322716.5	-	1	1354	c.1128A>G	c.(1126-1128)caA>caG	p.Q376Q		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	376						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						CACAAAGCCATTGTTTGTCTG	0.413000													93	98					0	0	0.000781405	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350395	51350395	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:51350395C>T	ENST00000327536.5	-	3	661	c.562G>A	c.(562-564)Gag>Aag	p.E188K	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	188										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		ACCAGCTCCTCTTGGCTAAAC	0.478000													22	49					0	0	0.000295444	0	0
PLXNA4	91584	broad.mit.edu	37	7	131925833	131925833	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:131925833C>T	ENST00000359827.3	-	5	2558	c.1596G>A	c.(1594-1596)ctG>ctA	p.L532L	PLXNA4_ENST00000321063.4_Silent_p.L532L			Q9HCM2	PLXA4_HUMAN	plexin A4	532	PSI 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ACGTGTTGTGCAGCACACACC	0.592000													11	34					0	0	0.000978159	0	0
ATP5B	506	broad.mit.edu	37	12	57033060	57033060	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:57033060A>C	ENST00000262030.3	-	9	1369	c.1319T>G	c.(1318-1320)aTc>aGc	p.I440S	ATP5B_ENST00000552919.1_Missense_Mutation_p.I429S	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	440					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CATACCCAGGATGGCAATGAT	0.433000													6	60					0	0	8.12818e-05	0	0
OR5B3	441608	broad.mit.edu	37	11	58170414	58170414	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:58170414G>T	ENST00000309403.2	-	1	468	c.469C>A	c.(469-471)Cac>Aac	p.H157N		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCCCCAGTGTGGATGGAGGCA	0.468000													21	63					1.50039e-11	1.27752e-10	0.00188189	1	0
LPCAT4	254531	broad.mit.edu	37	15	34651828	34651828	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:34651828T>A	ENST00000314891.6	-	13	1538	c.1361A>T	c.(1360-1362)gAg>gTg	p.E454V		NM_153613.2	NP_705841.2	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	454					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding			NS(1)|breast(1)|large_intestine(2)|lung(5)|prostate(1)	10						CTGGCACAGCTCAGCATGCAA	0.622000													8	21					0	0	0.000673444	0	0
TBRG4	9238	broad.mit.edu	37	7	45143786	45143786	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:45143786C>A	ENST00000258770.3	-	5	1098	c.977G>T	c.(976-978)aGc>aTc	p.S326I	TBRG4_ENST00000395655.4_Intron|TBRG4_ENST00000361278.3_Intron|TBRG4_ENST00000494076.1_Missense_Mutation_p.S326I	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	326					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						AGAAGTCAGGCTGGGCATGAG	0.607000													16	35					4.7546e-09	3.65771e-08	0.000422831	1	0
AMPD1	270	broad.mit.edu	37	1	115229511	115229511	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:115229511C>G	ENST00000369538.3	-	3	370	c.323G>C	c.(322-324)cGg>cCg	p.R108P	AMPD1_ENST00000353928.6_Missense_Mutation_p.R79P|AMPD1_ENST00000520113.2_Missense_Mutation_p.R112P	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	79					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AACAGTCTTCCGTCCTTGGAA	0.383000													10	58					0	0	0.00136819	0	0
TRIM55	84675	broad.mit.edu	37	8	67040549	67040549	+	Missense_Mutation	SNP	C	C	G	rs61760894		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:67040549C>G	ENST00000315962.4	+	2	552	c.179C>G	c.(178-180)cCg>cGg	p.P60R	TRIM55_ENST00000353317.5_Missense_Mutation_p.P60R|TRIM55_ENST00000350034.4_Missense_Mutation_p.P60R|TRIM55_ENST00000276573.7_Missense_Mutation_p.P60R	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	60						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GCCTCTAACCCGTATTTGCCC	0.473000													31	91					0	0	0.00148497	0	0
OR4X1	390113	broad.mit.edu	37	11	48285958	48285958	+	Silent	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:48285958G>T	ENST00000320048.1	+	1	546	c.546G>T	c.(544-546)gtG>gtT	p.V182V		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TCCACCCAGTGCTGGAGCTGG	0.552000													5	29					8.12818e-05	0.000572564	8.12818e-05	1	0
DPP6	1804	broad.mit.edu	37	7	154172103	154172103	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:154172103C>T	ENST00000404039.1	+	3	833	c.246C>T	c.(244-246)ccC>ccT	p.P82P	DPP6_ENST00000377770.3_Silent_p.P146P|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000406326.1_Silent_p.P146P|DPP6_ENST00000427557.1_Silent_p.P84P|DPP6_ENST00000332007.3_Silent_p.P84P	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	146					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity	p.P146P(2)|p.P84P(1)|p.P82P(1)		NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTCATGACCCCGAGGCTAAGT	0.433000													10	51					0	0	0.00185496	0	0
PFKL	5211	broad.mit.edu	37	21	45744486	45744486	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr21:45744486G>T	ENST00000403390.1	+	18	1904	c.1904G>T	c.(1903-1905)gGg>gTg	p.G635V	PFKL_ENST00000349048.4_Missense_Mutation_p.G588V			P17858	K6PL_HUMAN	phosphofructokinase, liver	588					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		ATTGCTGTGGGGGCCGACGCC	0.632000													23	40					1.88708e-17	1.83886e-16	0.001512	1	0
TMEM132D	121256	broad.mit.edu	37	12	129569171	129569171	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:129569171G>T	ENST00000422113.2	-	6	1846	c.1520C>A	c.(1519-1521)aCc>aAc	p.T507N	TMEM132D_ENST00000389441.4_Missense_Mutation_p.T45N	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	507						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTGCTGGTAGGTGAAGTTCAC	0.537000													11	47					9.31168e-06	6.69372e-05	0.00185496	1	0
CNTN5	53942	broad.mit.edu	37	11	99690359	99690359	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:99690359G>T	ENST00000524871.1	+	4	430	c.140G>T	c.(139-141)gGt>gTt	p.G47V	CNTN5_ENST00000279463.3_Missense_Mutation_p.G47V|CNTN5_ENST00000528682.1_Missense_Mutation_p.G47V|CNTN5_ENST00000418526.2_Intron|CNTN5_ENST00000527185.1_Missense_Mutation_p.G47V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	47					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCTCTCTTTGGTTCCAAAACC	0.423000													9	75					7.03913e-09	5.39154e-08	0.00136819	1	0
IQGAP2	10788	broad.mit.edu	37	5	75991309	75991309	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:75991309C>A	ENST00000274364.6	+	32	4321	c.4024C>A	c.(4024-4026)Cgt>Agt	p.R1342S	IQGAP2_ENST00000396234.3_Missense_Mutation_p.R838S|IQGAP2_ENST00000502745.1_Missense_Mutation_p.R838S|IQGAP2_ENST00000379730.3_Missense_Mutation_p.R844S|CTD-2384B11.2_ENST00000507514.1_RNA	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1342					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CATGGTGAGCCGTGCAATGAT	0.433000													9	46					0.000442599	0.00304439	0.000442599	1	0
STAC	6769	broad.mit.edu	37	3	36485098	36485098	+	Silent	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:36485098C>A	ENST00000273183.3	+	2	654	c.354C>A	c.(352-354)ccC>ccA	p.P118P	STAC_ENST00000476388.1_3'UTR|STAC_ENST00000457375.2_Silent_p.P118P	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	118					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						TCAAGAAGCCCACTTTCTGTG	0.577000													28	66					6.02846e-25	6.33168e-24	0.00058488	1	0
CDC27	996	broad.mit.edu	37	17	45214646	45214646	+	Silent	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:45214646T>C	ENST00000066544.3	-	14	1878	c.1785A>G	c.(1783-1785)caA>caG	p.Q595Q	CDC27_ENST00000531206.1_Silent_p.Q601Q|CDC27_ENST00000527547.1_Silent_p.Q594Q|CDC27_ENST00000446365.2_Silent_p.Q534Q	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	595					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TTGGATCAACTTGGATAGCTC	0.388000													4	68					0	0	0.000157383	0	0
NEB	4703	broad.mit.edu	37	2	152425821	152425821	+	Silent	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:152425821G>A	ENST00000397345.3	-	110	17698	c.17496C>T	c.(17494-17496)tcC>tcT	p.S5832S	NEB_ENST00000603639.1_Silent_p.S5832S|NEB_ENST00000409198.1_Silent_p.S4131S|NEB_ENST00000427231.2_Silent_p.S5832S|NEB_ENST00000172853.10_Silent_p.S4131S|NEB_ENST00000604864.1_Silent_p.S5832S	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5851					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGATTGACGGACACGGAGT	0.458000													13	85					0	0	0.000308642	0	0
GABRA5	2558	broad.mit.edu	37	15	27128526	27128526	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr15:27128526G>T	ENST00000335625.5	+	6	1207	c.319G>T	c.(319-321)Gaa>Taa	p.E107*	GABRA5_ENST00000355395.5_Nonsense_Mutation_p.E107*|GABRA5_ENST00000400081.3_Nonsense_Mutation_p.E107*|GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000557449.1_Intron	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	107					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGGAAAGATGAAAGGCTTCG	0.577000													11	88					2.31682e-05	0.000165866	0.000308642	1	0
BSCL2	26580	broad.mit.edu	37	11	62462041	62462041	+	Splice_Site	SNP	G	G	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:62462041G>A	ENST00000433053.1	-	5	1185	c.630_splice	c.e5+1	p.S210_splice	BSCL2_ENST00000407022.3_Splice_Site_p.S146_splice|BSCL2_ENST00000360796.5_Splice_Site_p.S210_splice|BSCL2_ENST00000421906.1_Splice_Site_p.S146_splice|BSCL2_ENST00000405837.1_Splice_Site_p.S210_splice|BSCL2_ENST00000278893.7_Splice_Site_p.S146_splice|BSCL2_ENST00000537604.1_5'UTR|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000403550.1_Splice_Site_p.S146_splice			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	146					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						AACACTTACCGAACGCGAAGA	0.547000													14	70					0	0	0.00074312	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963407	73963407	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:73963407T>A	ENST00000373468.1	-	3	1636	c.985A>T	c.(985-987)Atg>Ttg	p.M329L	KIAA2022_ENST00000055682.5_Missense_Mutation_p.M329L			Q5QGS0	K2022_HUMAN	KIAA2022	329					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCTTCCTGCATCAAAAGAGTA	0.448000													54	28					0	0	0.000781405	0	0
SEZ6L	23544	broad.mit.edu	37	22	26707786	26707786	+	Silent	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr22:26707786T>C	ENST00000529632.2	+	8	1930	c.1734T>C	c.(1732-1734)acT>acC	p.T578T	SEZ6L_ENST00000402979.1_Silent_p.T351T|SEZ6L_ENST00000343706.4_Silent_p.T578T|SEZ6L_ENST00000360929.3_Silent_p.T578T|SEZ6L_ENST00000248933.6_Silent_p.T578T|SEZ6L_ENST00000404234.3_Silent_p.T578T|SEZ6L_ENST00000403121.1_Silent_p.T351T	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	578	Sushi 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GGAACTTCACTACATCCGACC	0.547000													49	182					0	0	0.000781405	0	0
NPAS4	266743	broad.mit.edu	37	11	66191665	66191665	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:66191665C>A	ENST00000311034.2	+	7	1480	c.1304C>A	c.(1303-1305)gCc>gAc	p.A435D		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	435					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GGAGGCTGTGCCTTCCTCTTC	0.557000													11	253					2.68362e-12	2.33023e-11	0.00136819	1	0
L1CAM	3897	broad.mit.edu	37	X	153130294	153130294	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:153130294C>G	ENST00000370060.1	-	23	3217	c.3028G>C	c.(3028-3030)Ggc>Cgc	p.G1010R	L1CAM_ENST00000538883.1_Missense_Mutation_p.G1012R|L1CAM_ENST00000361981.3_Missense_Mutation_p.G1005R|L1CAM_ENST00000370055.1_Missense_Mutation_p.G1005R|L1CAM_ENST00000370057.3_Missense_Mutation_p.G1010R|L1CAM_ENST00000361699.4_Missense_Mutation_p.G1010R|L1CAM_ENST00000543994.1_Missense_Mutation_p.G1012R	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	1010	Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCATAGTGCCTCCTTCCCGT	0.632000													5	80					0	0	0.000157383	0	0
LEF1	51176	broad.mit.edu	37	4	109000667	109000667	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:109000667C>G	ENST00000379951.2	-	6	1930	c.742G>C	c.(742-744)Gac>Cac	p.D248H	LEF1_ENST00000438313.2_Missense_Mutation_p.D248H|LEF1_ENST00000265165.1_Missense_Mutation_p.D276H|LEF1_ENST00000510624.1_Missense_Mutation_p.D180H	NM_001130713.2|NM_001130714.2	NP_001124185.1|NP_001124186.1	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1	276	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	25				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		AGGTCACTGTCAGTGTGGGGA	0.502000													13	83					0	0	0.000422831	0	0
TESPA1	9840	broad.mit.edu	37	12	55356904	55356904	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:55356904G>T	ENST00000524622.1	-	7	1025	c.364C>A	c.(364-366)Cat>Aat	p.H122N	TESPA1_ENST00000449076.1_Missense_Mutation_p.H260N|TESPA1_ENST00000531122.1_Missense_Mutation_p.H122N|TESPA1_ENST00000316577.8_Missense_Mutation_p.H260N|TESPA1_ENST00000532804.1_Missense_Mutation_p.H122N	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	260																	TCAGTTGGATGGTTGCAATTC	0.507000													13	18					4.7546e-09	3.65771e-08	0.000422831	1	0
VIT	5212	broad.mit.edu	37	2	36970274	36970274	+	Silent	SNP	C	C	A	rs146980566		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:36970274C>A	ENST00000379242.3	+	4	452	c.150C>A	c.(148-150)gcC>gcA	p.A50A	VIT_ENST00000389975.3_Silent_p.A50A|VIT_ENST00000404084.1_Silent_p.A28A|VIT_ENST00000401530.1_Silent_p.A50A|VIT_ENST00000457137.2_Silent_p.A50A|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000379241.3_Silent_p.A50A	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	50	LCCL.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				ATGTCAAAGCCGGAAAGATCA	0.448000													12	92					9.31168e-06	6.69372e-05	0.00185496	1	0
SEPT14	346288	broad.mit.edu	37	7	55914312	55914312	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:55914312G>T	ENST00000388975.3	-	3	189	c.73C>A	c.(73-75)Cgt>Agt	p.R25S	SEPT14_ENST00000477628.1_5'UTR	NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	25					cell cycle|cell division	septin complex	GTP binding|protein binding	p.R25C(2)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTTAAACAACGAATATTATTT	0.284000													21	39					5.26018e-13	4.68343e-12	0.00188189	1	0
ZNF649	65251	broad.mit.edu	37	19	52394419	52394419	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:52394419C>A	ENST00000354957.3	-	5	1254	c.970G>T	c.(970-972)Gga>Tga	p.G324*	ZNF649_ENST00000600738.1_Nonsense_Mutation_p.G296*|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		AAGCCTTTTCCACATTCACTG	0.458000													7	38					0.000274275	0.00189401	0.000274275	1	0
CACNG6	59285	broad.mit.edu	37	19	54515421	54515421	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:54515421A>G	ENST00000252729.2	+	4	1351	c.761A>G	c.(760-762)aAg>aGg	p.K254R	CACNG6_ENST00000346968.2_Missense_Mutation_p.K208R|CACNG6_ENST00000352529.1_Missense_Mutation_p.K183R	NM_145814.1	NP_665813.1	Q9BXT2	CCG6_HUMAN	calcium channel, voltage-dependent, gamma subunit 6	254						voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CTCTGTCCCAAGCGGGGGCAC	0.652000													17	61					0	0	0.00121646	0	0
STAC	6769	broad.mit.edu	37	3	36485097	36485097	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:36485097C>A	ENST00000273183.3	+	2	653	c.353C>A	c.(352-354)cCc>cAc	p.P118H	STAC_ENST00000476388.1_3'UTR|STAC_ENST00000457375.2_Missense_Mutation_p.P118H	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	118					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						TTCAAGAAGCCCACTTTCTGT	0.577000													27	68					9.78485e-24	1.02158e-22	0.000491102	1	0
PKD1	5310	broad.mit.edu	37	16	2147377	2147377	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr16:2147377C>A	ENST00000262304.4	-	33	10556	c.10348G>T	c.(10348-10350)Gag>Tag	p.E3450*	PKD1_ENST00000423118.1_Nonsense_Mutation_p.E3449*	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3450					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AAGCCGTCCTCCTCTGGGCCC	0.657000													8	30					1.58986e-06	1.15232e-05	0.000673444	1	0
KIF21B	23046	broad.mit.edu	37	1	200945903	200945903	+	Splice_Site	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:200945903C>G	ENST00000332129.2	-	31	4721		c.e31+1		KIF21B_ENST00000360529.5_Splice_Site|KIF21B_ENST00000422435.2_Splice_Site|KIF21B_ENST00000461742.2_Splice_Site	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGCTGAGGTACCTTAACGTAG	0.572000													5	31					0	0	0.000602214	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21391972	21391972	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:21391972T>C	ENST00000256958.2	+	15	2021	c.1925T>C	c.(1924-1926)aTa>aCa	p.I642T		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	642					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ttatatattatattaatttat	0.279000													31	16					0	0	0.00111076	0	0
ZNF536	9745	broad.mit.edu	37	19	31039823	31039823	+	Silent	SNP	C	C	T			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:31039823C>T	ENST00000355537.3	+	4	3444	c.3297C>T	c.(3295-3297)caC>caT	p.H1099H		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1099					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGACCGGCCACGTGGACCCTG	0.542000													5	63					0	0	0.000274275	0	0
BCL11A	53335	broad.mit.edu	37	2	60773317	60773317	+	Silent	SNP	C	C	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr2:60773317C>G	ENST00000335712.6	-	2	401	c.174G>C	c.(172-174)ggG>ggC	p.G58G	BCL11A_ENST00000358510.4_Silent_p.G58G|BCL11A_ENST00000538214.1_Silent_p.G58G|BCL11A_ENST00000359629.5_Silent_p.G58G|BCL11A_ENST00000356842.4_Silent_p.G58G|BCL11A_ENST00000537768.1_5'UTR	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	58	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TAAGAATGTCCCCCAATGGGA	0.502000			T	IGH@	B-CLL								19	42					0	0	0.000958276	0	0
PCDH18	54510	broad.mit.edu	37	4	138451598	138451598	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr4:138451598C>A	ENST00000344876.4	-	1	2031	c.1645G>T	c.(1645-1647)Gat>Tat	p.D549Y	PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.D329Y|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.D549Y	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	549	Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CTTCCTCCATCTCTTGCTTCT	0.448000													32	98					1.56738e-10	1.29001e-09	0.000814825	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176003	140176003	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr5:140176003A>G	ENST00000526136.1	+	1	1454	c.1454A>G	c.(1453-1455)cAg>cGg	p.Q485R	PCDHA2_ENST00000378132.1_Missense_Mutation_p.Q485R|PCDHA2_ENST00000520672.2_Missense_Mutation_p.Q485R|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGACGCGCAGGAGAACGCG	0.657000													6	94					0	0	0.000274275	0	0
PADI2	11240	broad.mit.edu	37	1	17402183	17402183	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr1:17402183delG	ENST00000375486.4	-	12	1509	c.1446delC	c.(1444-1446)ccfs	p.P482fs	PADI2_ENST00000444885.2_Frame_Shift_Del_p.P366fs|PADI2_ENST00000466151.1_5'UTR	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	482					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CCTTTGTGCCGGGGATGGGGA	0.587											OREG0013145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	89	---	---	---	---					
CNTN6	27255	broad.mit.edu	37	3	1269671	1269671	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:1269671delT	ENST00000446702.2	+	4	979	c.352delT	c.(352-354)ttfs	p.F118fs	CNTN6_ENST00000539053.1_Frame_Shift_Del_p.F46fs|CNTN6_ENST00000350110.2_Frame_Shift_Del_p.F118fs			Q9UQ52	CNTN6_HUMAN	contactin 6	118					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAGCTCCAATTTGCATGTGA	0.388													60	78	---	---	---	---					
RP11-314M24.1	0	broad.mit.edu	37	3	78320208	78320210	+	RNA	DEL	TCC	TCC	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:78320208_78320210delTCC	ENST00000484679.1	+	0	128																											ctcctcctcgtcctcctcctcct	0.419													2	4	---	---	---	---					
SMC4	10051	broad.mit.edu	37	3	160143940	160143940	+	Frame_Shift_Del	DEL	A	A	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr3:160143940delA	ENST00000357388.3	+	17	3008	c.2557delA	c.(2557-2559)aafs	p.K855fs	SMC4_ENST00000344722.5_Frame_Shift_Del_p.K855fs|SMC4_ENST00000462787.1_Frame_Shift_Del_p.K855fs|SMC4_ENST00000469762.1_Frame_Shift_Del_p.K830fs|RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000360111.2_Frame_Shift_Del_p.K855fs	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	855					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGCCCCTGACAAAAAAAAGCA	0.323													8	376	---	---	---	---					
SMAP1	60682	broad.mit.edu	37	6	71508369	71508370	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr6:71508369_71508370insA	ENST00000370455.3	+	6	753_754	c.505_506insA	c.(505-507)aaafs	p.K169fs	SMAP1_ENST00000370452.3_Frame_Shift_Ins_p.K142fs|SMAP1_ENST00000316999.5_Frame_Shift_Ins_p.K142fs	NM_001044305.1	NP_001037770.1	Q8IYB5	SMAP1_HUMAN	small ArfGAP 1	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding	p.K145fs*48(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						gaaagaaaaggaaaaaaaaaag	0.287													3	6	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82585022	82585022	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr7:82585022delT	ENST00000423517.2	-	5	5584	c.5247delA	c.(5245-5247)aafs	p.K1749fs	PCLO_ENST00000333891.8_Frame_Shift_Del_p.K1749fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1680					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGCTCTCTCCTTTTTTGTGAC	0.478													7	341	---	---	---	---					
CSMD3	114788	broad.mit.edu	37	8	113304884	113304885	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr8:113304884_113304885insA	ENST00000297405.5	-	55	8913_8914	c.8669_8670insT	c.(8668-8670)gttfs	p.V2890fs	CSMD3_ENST00000343508.3_Frame_Shift_Ins_p.V2850fs|CSMD3_ENST00000455883.2_Frame_Shift_Ins_p.V2721fs|CSMD3_ENST00000352409.3_Frame_Shift_Ins_p.V2820fs	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2890	Sushi 19.					integral to membrane|plasma membrane		p.G2890E(1)|p.G2890G(1)|p.G2850G(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAAAGTTGAACCCATTTCCACT	0.446										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	111	---	---	---	---					
FAU	2197	broad.mit.edu	37	11	64888248	64888250	+	In_Frame_Del	DEL	TCT	TCT	-	rs1065065		TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr11:64888248_64888250delTCT	ENST00000529639.1	-	5	696_698	c.305_307delAGA	c.(304-309)aca>a	p.KT102del	FAU_ENST00000525297.1_In_Frame_Del_p.KT67del|FAU_ENST00000527548.1_In_Frame_Del_p.KT102del|FAU_ENST00000531743.1_In_Frame_Del_p.KT102del|FAU_ENST00000279259.3_In_Frame_Del_p.ED83del|FAU_ENST00000529259.1_3'UTR	NM_001997.4	NP_001988.1	P35544	UBIM_HUMAN	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	0										NS(3)|kidney(1)|large_intestine(2)	6						GCCCGACCTGTCTTCTTCTTCTT	0.542													9	166	---	---	---	---					
HOXC8	3224	broad.mit.edu	37	12	54403325	54403325	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr12:54403325delC	ENST00000040584.4	+	1	494	c.257delC	c.(256-258)tcfs	p.S86fs		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	86						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						GGAGACGCCTCCAAATTCTAT	0.587													93	208	---	---	---	---					
YY1	7528	broad.mit.edu	37	14	100705708	100705710	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:100705708_100705710delGAG	ENST00000262238.4	+	1	387_389	c.127_129delGAG	c.(127-129)del	p.E47del		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	47	Asp/Glu-rich (acidic).				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding	p.E43delE(1)		cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				AGTggtgggcgaggaggaggagg	0.719													9	28	---	---	---	---					
IGHV3-48	28424	broad.mit.edu	37	14	106993939	106993941	+	RNA	DEL	TAC	TAC	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr14:106993939_106993941delTAC	ENST00000390624.2	-	0	302_304																											TAGTATATGGTACTACTACTACT	0.502													8	457	---	---	---	---					
SRCIN1	80725	broad.mit.edu	37	17	36720500	36720500	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr17:36720500delT	ENST00000264659.7	-	4	619	c.395delA	c.(394-396)cgfs	p.Q132fs	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Frame_Shift_Del_p.Q166fs	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	149					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						CTTTGCCGCCTGGTCTGCCAG	0.697													2	4	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1220410	1220410	+	Frame_Shift_Del	DEL	A	A	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:1220410delA	ENST00000326873.7	+	4	1676	c.503delA	c.(502-504)ctfs	p.H168fs		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	168	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.Y156fs*87(4)|p.?(4)|p.H168R(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGTACCTGCATAGCCAGGGC	0.647		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			7	8	---	---	---	---					
GLTSCR1	29998	broad.mit.edu	37	19	48204803	48204805	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chr19:48204803_48204805delTCC	ENST00000396720.3	+	15	4008_4010	c.3814_3816delTCC	c.(3814-3816)del	p.S1276del	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1276	Poly-Ser.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		gtcctcctcttcctcctcctcct	0.719													2	4	---	---	---	---					
CRLF2	64109	broad.mit.edu	37	X	1321390	1321390	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrX:1321390delG	ENST00000381567.3	-	4	364	c.365delC	c.(364-366)cgfs	p.P122fs	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Frame_Shift_Del_p.P122fs	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	122	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CACGTGCTTCGGGGAACTGGG	0.542			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								14	152	---	---	---	---					
UTY	7404	broad.mit.edu	37	Y	15448217	15448218	+	Splice_Site	INS	-	-	A			TCGA-86-7701-01A-11D-2167-08	TCGA-86-7701-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c4b3488-96b4-436c-81d6-b020d3f2a2a7	2223166b-1a51-43dd-bc3c-12e5ebdfdfc8	g.chrY:15448217_15448218insA	ENST00000331397.4	-	16	2778		c.e16-2		UTY_ENST00000540140.1_Splice_Site|UTY_ENST00000329134.5_Splice_Site|UTY_ENST00000537580.1_Splice_Site|UTY_ENST00000362096.4_Splice_Site|UTY_ENST00000545955.1_Splice_Site|UTY_ENST00000382896.4_Splice_Site|UTY_ENST00000538878.1_Splice_Site	NM_001258267.1|NM_007125.4	NP_001245196.1|NP_009056.3	O14607	UTY_HUMAN	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked						chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(6)	7						ATGAAGCCCCTAAAAAAAAAAA	0.361													4	3	---	---	---	---					
