Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CT47B1	643311	broad.mit.edu	37	X	120008813	120008813	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:120008813C>G	ENST00000371311.3	-	1	966	c.712G>C	c.(712-714)Gag>Cag	p.E238Q		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	238								p.K235_E243delKLTEEATEE(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						gtggcctcctctgtgagcttc	0.697000													55	41					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109275927	109275927	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:109275927G>T	ENST00000370017.3	+	10	2190	c.1913G>T	c.(1912-1914)aGg>aTg	p.R638M	FNDC7_ENST00000271311.2_Missense_Mutation_p.R639M	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	639	Fibronectin type-III 8.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AAATTATATAGGCTGGGCCCT	0.478000													85	191					6.0678e-26	1.02796e-25	1	1	0
EPSTI1	94240	broad.mit.edu	37	13	43500532	43500532	+	Silent	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:43500532T>A	ENST00000313640.7	-	7	661	c.597A>T	c.(595-597)acA>acT	p.T199T	EPSTI1_ENST00000398762.3_Silent_p.T199T|EPSTI1_ENST00000476830.2_5'UTR|EPSTI1_ENST00000313624.7_Silent_p.T199T	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	199										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		CTGGCGATTCTGTGTTCAGTT	0.423000													66	155					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170058244	170058244	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:170058244G>A	ENST00000263816.3	-	44	8631	c.8346C>T	c.(8344-8346)gcC>gcT	p.A2782A		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2782	LDL-receptor class A 18.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACTCCGTGGTGGCATTGCAGT	0.463000													21	68					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4015805	4015805	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:4015805T>A	ENST00000294016.3	-	11	4571	c.4033A>T	c.(4033-4035)Acc>Tcc	p.T1345S		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1345				QHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSL GSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCD ETGIEEANELTKLNVSKSV -> APAVHLPRHPRPGGWQHR TVSHRRDCQPGAFCPVCGQDISGF (in Ref. 1; AAC24201).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TTGAGCTTGGTGAGTTCGTTG	0.507000													32	79					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45725760	45725760	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:45725760G>T	ENST00000297323.7	+	13	2295	c.2273G>T	c.(2272-2274)gGg>gTg	p.G758V		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	758					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	CTGCTCTCCGGGCTCACCACG	0.572000													36	83					3.76114e-14	5.50783e-14	1	1	0
ITGA8	8516	broad.mit.edu	37	10	15617547	15617547	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:15617547G>T	ENST00000378076.3	-	24	2772	c.2419C>A	c.(2419-2421)Cca>Aca	p.P807T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	807					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TCCTCTTCTGGTTCCCAGTTA	0.443000													27	69					9.78306e-22	1.61309e-21	1	1	0
BRD2	6046	broad.mit.edu	37	6	32944374	32944374	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:32944374C>T	ENST00000395289.2	+	7	2462	c.861C>T	c.(859-861)acC>acT	p.T287T	BRD2_ENST00000395287.1_Silent_p.T287T|BRD2_ENST00000374825.4_Silent_p.T287T|BRD2_ENST00000449085.2_Silent_p.T240T|BRD2_ENST00000443797.2_Silent_p.T167T|BRD2_ENST00000374831.4_Silent_p.T287T			P25440	BRD2_HUMAN	bromodomain containing 2	287					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						ATACTACCACCCCTACACCTA	0.527000													23	125					0	0	1	0	0
OSR2	116039	broad.mit.edu	37	8	99961674	99961674	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:99961674C>A	ENST00000297565.4	+	2	990	c.494C>A	c.(493-495)cCc>cAc	p.P165H	OSR2_ENST00000523368.1_Missense_Mutation_p.P165H|OSR2_ENST00000457907.2_Missense_Mutation_p.P286H|OSR2_ENST00000522510.1_Missense_Mutation_p.P165H|OSR2_ENST00000435298.2_Missense_Mutation_p.P165H	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	165					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GGAAGGTTGCCCTCCAAAACG	0.517000													163	196					6.64659e-83	1.243e-82	1	1	0
DSC1	1823	broad.mit.edu	37	18	28719718	28719718	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr18:28719718C>A	ENST00000257197.3	-	11	1917	c.1656G>T	c.(1654-1656)gtG>gtT	p.V552V	DSC1_ENST00000257198.5_Silent_p.V552V|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	552	Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CACCTGCATCCACTGCAACAA	0.308000													15	39					2.23348e-06	2.57297e-06	1	1	0
PTPRO	5800	broad.mit.edu	37	12	15733670	15733670	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:15733670C>A	ENST00000281171.4	+	22	3367	c.3037C>A	c.(3037-3039)Cca>Aca	p.P1013T	PTPRO_ENST00000348962.2_Missense_Mutation_p.P985T|PTPRO_ENST00000544244.1_Missense_Mutation_p.P174T|PTPRO_ENST00000442921.2_Missense_Mutation_p.P202T|PTPRO_ENST00000542557.1_Missense_Mutation_p.P174T|PTPRO_ENST00000445537.2_Missense_Mutation_p.P202T	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	1013	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				CACCCAGGGGCCACTGCCTGA	0.453000													32	62					1.88708e-17	2.96444e-17	1	1	0
CCNB1	891	broad.mit.edu	37	5	68470846	68470846	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:68470846G>T	ENST00000256442.5	+	6	1101	c.848G>T	c.(847-849)aGa>aTa	p.R283I		NM_031966.3	NP_114172.1	P14635	CCNB1_HUMAN	cyclin B1	283					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole				large_intestine(2)|lung(5)|skin(1)	8		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CACCAAATCAGACAGATGGAA	0.413000													63	157					3.37043e-27	5.8241e-27	1	1	0
VSIG4	11326	broad.mit.edu	37	X	65247911	65247911	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:65247911G>T	ENST00000455586.2	-	4	864	c.738C>A	c.(736-738)acC>acA	p.T246T	VSIG4_ENST00000412866.2_Silent_p.T152T|VSIG4_ENST00000374737.4_Silent_p.T246T	NM_001184830.1	NP_001171759.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	246					complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GGTATGTCATGGTTGTAGGTG	0.453000													15	36					1.5739e-10	2.10503e-10	1	1	0
TSHZ3	57616	broad.mit.edu	37	19	31770157	31770157	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:31770157T>A	ENST00000240587.4	-	2	869	c.542A>T	c.(541-543)cAg>cTg	p.Q181L		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	181					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CATGCGGCTCTGTGACACCTG	0.642000													10	46					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81610498	81610498	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:81610498G>T	ENST00000541158.2	+	11	2418	c.2096G>T	c.(2095-2097)tGt>tTt	p.C699F	TSHR_ENST00000298171.2_Missense_Mutation_p.C699F|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	699					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TTTGGCATCTGTAAACGCCAG	0.498000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						51	135					2.14674e-31	3.8803e-31	1	1	0
EHD3	30845	broad.mit.edu	37	2	31489545	31489545	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:31489545C>A	ENST00000322054.5	+	6	1868	c.1583C>A	c.(1582-1584)cCg>cAg	p.P528Q	EHD3_ENST00000541626.1_3'UTR	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	528	EH.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					CTCCTGCCCCCGTCCAAGAGG	0.602000													16	56					6.31663e-08	7.64365e-08	1	1	0
TSHR	7253	broad.mit.edu	37	14	81610577	81610577	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:81610577C>A	ENST00000541158.2	+	11	2497	c.2175C>A	c.(2173-2175)acC>acA	p.T725T	TSHR_ENST00000298171.2_Silent_p.T725T|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	725					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AAAAGGTTACCCACGAGATGA	0.483000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						37	100					3.33393e-15	5.05354e-15	1	1	0
FAM83G	644815	broad.mit.edu	37	17	18881947	18881947	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:18881947G>A	ENST00000388995.6	-	5	1255	c.1032C>T	c.(1030-1032)ctC>ctT	p.L344L	SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395642.1_Intron|FAM83G_ENST00000345041.4_Silent_p.L344L|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000317977.6_Intron|FAM83G_ENST00000585154.2_Silent_p.L344L			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	344										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						TGGGGTTGACGAGCTTCTTGG	0.612000													32	101					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176903321	176903321	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:176903321G>T	ENST00000367654.2	-	16	2675	c.2662C>A	c.(2662-2664)Cga>Aga	p.R888R	ASTN1_ENST00000367657.3_Silent_p.R880R|ASTN1_ENST00000361833.2_Silent_p.R880R|ASTN1_ENST00000424564.2_Silent_p.R880R			O14525	ASTN1_HUMAN	astrotactin 1	888					cell migration|neuron cell-cell adhesion	integral to membrane		p.R880*(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						AGCCAGAGTCGCCGCTGGACC	0.502000													24	98					9.39395e-14	1.34823e-13	1	1	0
OR52R1	119695	broad.mit.edu	37	11	4825489	4825489	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:4825489G>T	ENST00000380382.1	-	1	358	c.359C>A	c.(358-360)gCt>gAt	p.A120D	OR52R1_ENST00000356069.2_Missense_Mutation_p.A41D|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCAACAACAGCCACAGCATA	0.512000													14	41					4.3838e-07	5.16022e-07	1	1	0
CALN1	83698	broad.mit.edu	37	7	71488747	71488747	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:71488747G>T	ENST00000395275.2	-	5	784	c.396C>A	c.(394-396)ggC>ggA	p.G132G	CALN1_ENST00000412588.1_Silent_p.G132G|CALN1_ENST00000395276.2_Silent_p.G90G|CALN1_ENST00000329008.5_Silent_p.G90G|CALN1_ENST00000431984.1_Silent_p.G90G|CALN1_ENST00000405452.2_Silent_p.G90G	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	90						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding	p.G90G(1)		biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AATCCACCTGGCCATCCCCTG	0.448000													30	62					3.69857e-22	6.16904e-22	1	1	0
EFCAB2	84288	broad.mit.edu	37	1	245165487	245165487	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:245165487G>T	ENST00000366522.2	+	2	527	c.386G>T	c.(385-387)gGt>gTt	p.G129V	EFCAB2_ENST00000366523.1_Intron|EFCAB2_ENST00000447569.2_Intron|EFCAB2_ENST00000487845.1_Intron			Q5VUJ9	EFCB2_HUMAN	EF-hand calcium binding domain 2	129							calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|stomach(2)	13	all_cancers(71;2.93e-06)|all_epithelial(71;2.13e-05)|all_lung(81;0.0337)|Lung NSC(105;0.0472)|Ovarian(71;0.0584)|Breast(184;0.0716)|all_neural(11;0.0982)		OV - Ovarian serous cystadenocarcinoma(106;0.015)			ctaatggaagGTGGAAGAAGA	0.468000													7	21					0.0477658	0.0488976	1	1	0
FEZF1	389549	broad.mit.edu	37	7	121942156	121942156	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:121942156C>T	ENST00000442488.2	-	4	1390	c.1323G>A	c.(1321-1323)ccG>ccA	p.P441P	FEZF1_ENST00000331178.4_Silent_p.P437P|FEZF1_ENST00000427185.2_Silent_p.P391P	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	441	Pro-rich.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						gcgggggcggcggTTCAGTGC	0.706000													13	45					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216011440	216011440	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:216011440T>A	ENST00000366943.2	-	47	9650	c.9264A>T	c.(9262-9264)gaA>gaT	p.E3088D	USH2A_ENST00000307340.3_Missense_Mutation_p.E3088D			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3088	Fibronectin type-III 17.		E -> K (in dbSNP:rs56056328).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGTGCAGACTTCAACCTGCA	0.383000										HNSCC(13;0.011)			82	162					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134427878	134427878	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:134427878C>T	ENST00000370766.3	-	3	2898	c.189G>A	c.(187-189)ccG>ccA	p.P63P	ZNF75D_ENST00000370764.1_Silent_p.P63P|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	63	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TAGTCTCAAGCGGTCCGGTTG	0.478000													4	57					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65838061	65838061	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:65838061A>C	ENST00000320580.4	+	1	137	c.104A>C	c.(103-105)cAg>cCg	p.Q35P		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	35	Gly-rich.|Poly-Gln.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						ccgccgccgcagcagcagcag	0.796000													2	5					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135865281	135865281	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:135865281C>A	ENST00000339463.3	+	10	1620	c.801C>A	c.(799-801)acC>acA	p.T267T	GFI1B_ENST00000372122.1_Silent_p.T267T|GFI1B_ENST00000372123.1_Silent_p.T221T|GFI1B_ENST00000450530.1_Silent_p.T267T|GFI1B_ENST00000534944.1_Silent_p.T221T|GFI1B_ENST00000372124.1_Silent_p.T221T			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	267	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		AGAAGCACACCTACATCCACA	0.622000													11	30					2.80697e-09	3.57703e-09	1	1	0
FOXI2	399823	broad.mit.edu	37	10	129535892	129535892	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:129535892C>A	ENST00000388920.4	+	1	394	c.355C>A	c.(355-357)Ccg>Acg	p.P119T		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	119					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				CCAGAGCGCGCCGCTGCGGAA	0.657000													4	4					0.00909568	0.00958374	1	1	0
LAMA4	3910	broad.mit.edu	37	6	112457369	112457369	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:112457369C>T	ENST00000230538.7	-	25	3767	c.3370G>A	c.(3370-3372)Gat>Aat	p.D1124N	LAMA4_ENST00000389463.4_Missense_Mutation_p.D1117N|LAMA4_ENST00000424408.2_Missense_Mutation_p.D1117N|LAMA4_ENST00000522006.1_Missense_Mutation_p.D1117N	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1124	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTTAACGTATCTTCAAGATGC	0.363000													22	63					0	0	1	0	0
TEKT4P2	100132288	broad.mit.edu	37	21	9907198	9907198	+	RNA	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr21:9907198C>T	ENST00000416067.1	-	0	1594					NR_037872.1|NR_038327.1																						GTGCAGAAAGCTAACGCACTG	0.592000													4	15					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42328858	42328858	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:42328858G>A	ENST00000262418.6	-	18	2565	c.2410C>T	c.(2410-2412)Cag>Tag	p.Q804*		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	804	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCAAAGAGCTGGATGCCGCTG	0.587000													21	56					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139943247	139943247	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:139943247G>A	ENST00000355097.2	-	9	1397	c.1350C>T	c.(1348-1350)gcC>gcT	p.A450A	ENTPD2_ENST00000460614.1_5'UTR|ENTPD2_ENST00000312665.5_Silent_p.A427A	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	450						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCGGCGGGTCGGCGGGGATCA	0.701000													8	15					0	0	1	0	0
PAX5	5079	broad.mit.edu	37	9	36966649	36966649	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:36966649C>A	ENST00000358127.4	-	6	751	c.677G>T	c.(676-678)gGa>gTa	p.G226V	PAX5_ENST00000377852.2_Missense_Mutation_p.G226V|PAX5_ENST00000377853.2_Missense_Mutation_p.G226V|PAX5_ENST00000523241.1_Missense_Mutation_p.G226V|PAX5_ENST00000520154.1_Missense_Mutation_p.G226V|PAX5_ENST00000523145.1_Missense_Mutation_p.G118V|PAX5_ENST00000414447.1_Missense_Mutation_p.G183V|PAX5_ENST00000522003.1_Missense_Mutation_p.G118V|PAX5_ENST00000446742.1_Missense_Mutation_p.G160V|PAX5_ENST00000520281.1_Missense_Mutation_p.G183V|PAX5_ENST00000377847.2_Missense_Mutation_p.G226V	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	226					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(41)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GAACAAGTCTCCCCGCATCTG	0.592000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								8	35					5.18039e-06	5.93615e-06	1	1	0
WDR91	29062	broad.mit.edu	37	7	134879799	134879799	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:134879799C>G	ENST00000354475.4	-	9	1313	c.1282G>C	c.(1282-1284)Gta>Cta	p.V428L	WDR91_ENST00000344400.5_Missense_Mutation_p.V428L|WDR91_ENST00000423565.1_Missense_Mutation_p.V393L	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	428										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						ACCCCATCTACGTCTAAGCTG	0.532000													10	31					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857952	9857952	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:9857952G>T	ENST00000396573.2	-	14	3758	c.3449C>A	c.(3448-3450)cCc>cAc	p.P1150H	GRIN2A_ENST00000562109.1_Missense_Mutation_p.P1150H|GRIN2A_ENST00000330684.3_Missense_Mutation_p.P1150H|GRIN2A_ENST00000404927.2_Missense_Mutation_p.P1150H|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P1150H|GRIN2A_ENST00000535259.1_Missense_Mutation_p.P993H	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1150					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCCTGGTAGGGGTCCGGGAA	0.532000													50	154					3.86361e-14	5.63878e-14	1	1	0
MCM10	55388	broad.mit.edu	37	10	13240794	13240794	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:13240794G>T	ENST00000378694.1	+	15	2300	c.2225G>T	c.(2224-2226)gGc>gTc	p.G742V	MCM10_ENST00000484800.2_Missense_Mutation_p.G743V|MCM10_ENST00000378714.3_Missense_Mutation_p.G742V			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	743					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						AAACACACAGGCATCCTGAAA	0.433000													26	55					1.17739e-12	1.66765e-12	1	1	0
C5orf54	63920	broad.mit.edu	37	5	159821978	159821978	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:159821978T>C	ENST00000408953.3	-	2	1027	c.520A>G	c.(520-522)Att>Gtt	p.I174V	C5orf54_ENST00000523213.1_Missense_Mutation_p.I174V	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	174										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						gcaagctgaatacccacttta	0.393000													37	110					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530238	140530238	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140530238G>A	ENST00000231136.1	+	1	400	c.400G>A	c.(400-402)Gcc>Acc	p.A134T	PCDHB6_ENST00000543635.1_5'UTR	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		134					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAATTCCCTGCCAGAGAAAT	0.453000													55	126					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64062051	64062051	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:64062051G>T	ENST00000324472.4	-	1	306	c.123C>A	c.(121-123)gcC>gcA	p.A41A	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	41			A -> V (in dbSNP:rs10878074).		multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		CGCCGCCTAGGGCCGACTTTT	0.657000													23	53					6.44725e-10	8.46569e-10	1	1	0
ITM2A	9452	broad.mit.edu	37	X	78618125	78618125	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:78618125T>A	ENST00000434584.2	-	3	709	c.373A>T	c.(373-375)Att>Ttt	p.I125F	ITM2A_ENST00000469541.1_5'UTR|ITM2A_ENST00000373298.2_Missense_Mutation_p.I169F	NM_001171581.1	NP_001165052.1	O43736	ITM2A_HUMAN	integral membrane protein 2A	169						integral to membrane	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	18						GGCATAACAATAGAAGTATTG	0.398000													28	25					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182339892	182339892	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:182339892G>T	ENST00000397033.2	+	4	863	c.433G>T	c.(433-435)Ggg>Tgg	p.G145W	ITGA4_ENST00000478440.1_Intron|ITGA4_ENST00000339307.4_Missense_Mutation_p.G145W	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	145					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TCAGACTTGTGGGCATAGATG	0.403000													28	76					2.65835e-16	4.07236e-16	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22155820	22155820	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:22155820T>A	ENST00000397126.4	-	4	2164	c.2016A>T	c.(2014-2016)aaA>aaT	p.K672N	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TACTAAAGGCTTTGCCACATT	0.383000													25	80					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16638359	16638359	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:16638359G>T	ENST00000443444.2	+	12	2914	c.2774G>T	c.(2773-2775)cGt>cTt	p.R925L	CCDC144A_ENST00000456009.1_Missense_Mutation_p.R645L|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.R925L|CCDC144A_ENST00000399273.1_Missense_Mutation_p.R925L|CCDC144A_ENST00000360524.8_Missense_Mutation_p.R925L			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	925																	GCTGCTGTACGTGACTGTGAT	0.388000													14	33					4.36969e-10	5.7728e-10	1	1	0
SERPINA4	5267	broad.mit.edu	37	14	95030231	95030231	+	Missense_Mutation	SNP	C	C	G	rs140563422	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:95030231C>G	ENST00000557004.1	+	2	833	c.412C>G	c.(412-414)Cgc>Ggc	p.R138G	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Missense_Mutation_p.R138G|SERPINA4_ENST00000298841.5_Missense_Mutation_p.R138G			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	138					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity	p.R138G(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		GCTGGAAACACGCGTGGGCAG	0.562000													33	94					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3677976	3677976	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:3677976C>A	ENST00000294600.2	+	5	927	c.843C>A	c.(841-843)tcC>tcA	p.S281S		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	281										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AAGAGACATCCATGTCCCCAG	0.567000													9	44					0.000151284	0.00016844	1	1	0
LAMB4	22798	broad.mit.edu	37	7	107704342	107704342	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:107704342G>T	ENST00000388781.3	-	22	3008	c.2925C>A	c.(2923-2925)aaC>aaA	p.N975K	LAMB4_ENST00000205386.4_Missense_Mutation_p.N975K|LAMB4_ENST00000388780.3_Missense_Mutation_p.N975K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	975	Laminin EGF-like 10.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTACATCTATGTTGTTGTTGC	0.498000													43	89					1.68508e-10	2.24678e-10	1	1	0
HCFC2	29915	broad.mit.edu	37	12	104458365	104458365	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:104458365G>A	ENST00000229330.4	+	1	131	c.27G>A	c.(25-27)tgG>tgA	p.W9*		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	9					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						TCCTCAACTGGAGGCGAGTTT	0.692000													5	5					0	0	1	0	0
GOLGA6L2	283685	broad.mit.edu	37	15	23690510	23690510	+	Missense_Mutation	SNP	T	T	G	rs3866720	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:23690510T>G	ENST00000567107.1	-	2	212	c.160A>C	c.(160-162)Aat>Cat	p.N54H	GOLGA6L2_ENST00000312015.5_Missense_Mutation_p.N54H|GOLGA6L2_ENST00000345070.5_5'UTR					golgin A6 family-like 2											breast(1)|endometrium(7)	8						TTAGTGCCATTATTTATTTTC	0.498000													2	18					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67101698	67101698	+	Splice_Site	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:67101698G>T	ENST00000371037.4	+	4	248	c.171_splice	c.e4+1	p.S57_splice	SGIP1_ENST00000468286.1_Intron|SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Intron	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	57					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AAAAAGTTTCGGTAAGGAAAC	0.358000													25	54					2.44723e-14	3.59593e-14	1	1	0
CHD7	55636	broad.mit.edu	37	8	61757938	61757938	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:61757938A>G	ENST00000423902.2	+	23	5659	c.5180A>G	c.(5179-5181)tAc>tGc	p.Y1727C	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1727					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAGGACAGCTACAAGAAACAC	0.498000													22	29					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45609897	45609897	+	Silent	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:45609897A>T	ENST00000267430.5	+	3	829	c.744A>T	c.(742-744)ccA>ccT	p.P248P	FANCM_ENST00000556036.1_Silent_p.P248P|FANCM_ENST00000542564.2_Intron	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	248	Helicase ATP-binding.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GTGCCACACCAGGTAGTGATA	0.328000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				32	112					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38993320	38993320	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:38993320C>T	ENST00000355481.4	+	48	7919	c.7788C>T	c.(7786-7788)acC>acT	p.T2596T	RYR1_ENST00000360985.3_Silent_p.T2596T|RYR1_ENST00000359596.3_Silent_p.T2596T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2596	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTTCGCTCACCAAGGCGCAGC	0.667000													4	54					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46288438	46288438	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:46288438G>T	ENST00000378966.3	+	2	1586	c.1170G>T	c.(1168-1170)atG>atT	p.M390I	SPERT_ENST00000310521.1_Missense_Mutation_p.M426I			Q8NA61	SPERT_HUMAN	spermatid associated	426						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GCATGGAAATGCTCATCGAGG	0.612000													12	17					9.31168e-06	1.05859e-05	1	1	0
OR2L8	391190	broad.mit.edu	37	1	248112558	248112558	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:248112558C>A	ENST00000357191.3	+	1	399	c.399C>A	c.(397-399)atC>atA	p.I133I	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACTATCTCATCCGCATGAGCA	0.433000													77	377					8.16569e-41	1.50751e-40	1	1	0
OR6B2	389090	broad.mit.edu	37	2	240969238	240969238	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:240969238G>T	ENST00000402971.2	-	1	668	c.609C>A	c.(607-609)gcC>gcA	p.A203A		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GGATGATGAAGGCCAGGATGA	0.577000													8	37					0.00307968	0.00330129	1	1	0
OR10T2	128360	broad.mit.edu	37	1	158368636	158368636	+	Silent	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:158368636T>A	ENST00000334438.1	-	1	620	c.621A>T	c.(619-621)gtA>gtT	p.V207V		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					GCACCATAATTACCAGGATGC	0.453000													30	78					0	0	1	0	0
MT1JP	4498	broad.mit.edu	37	16	56669689	56669689	+	RNA	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:56669689C>T	ENST00000564564.1	+	0	15																											TGCGGTCTCTCCATTTATCGC	0.627000													23	55					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102826059	102826059	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:102826059C>A	ENST00000260302.3	-	2	312	c.284G>T	c.(283-285)aGa>aTa	p.R95I	MMP13_ENST00000340273.4_Missense_Mutation_p.R95I	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	95					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AACCCCGCATCTTGGCTTTTT	0.428000													44	144					1.7489e-18	2.77767e-18	1	1	0
MLLT6	4302	broad.mit.edu	37	17	36881059	36881059	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:36881059G>T	ENST00000325718.7	+	19	3161	c.3070G>T	c.(3070-3072)Gct>Tct	p.A1024S		NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	1024					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					CCTGCTGCCCGCTGGAGCCCT	0.677000			T	MLL	AL								4	5					0.150653	0.152775	1	1	0
RYR3	6263	broad.mit.edu	37	15	33895499	33895499	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:33895499T>A	ENST00000389232.4	+	18	2168	c.2098T>A	c.(2098-2100)Tgg>Agg	p.W700R	RYR3_ENST00000415757.3_Missense_Mutation_p.W700R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	700	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGAGAAGGATGGGGAGGCAA	0.552000													79	204					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717340	142717340	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:142717340C>A	ENST00000381779.4	-	2	1810	c.1585G>T	c.(1585-1587)Gag>Tag	p.E529*	SLITRK4_ENST00000356928.1_Nonsense_Mutation_p.E529*|SLITRK4_ENST00000338017.4_Nonsense_Mutation_p.E529*	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	529						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					GGGTTGCCCTCCAAGTCAATC	0.478000													89	48					2.56433e-40	4.71399e-40	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41101199	41101199	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:41101199G>T	ENST00000373198.3	-	8	1392	c.1157C>A	c.(1156-1158)cCg>cAg	p.P386Q	PTPRT_ENST00000373201.1_Missense_Mutation_p.P386Q|PTPRT_ENST00000356100.2_Missense_Mutation_p.P386Q|PTPRT_ENST00000373184.1_Missense_Mutation_p.P386Q|PTPRT_ENST00000373190.1_Missense_Mutation_p.P386Q|PTPRT_ENST00000373193.3_Missense_Mutation_p.P386Q|PTPRT_ENST00000373187.1_Missense_Mutation_p.P386Q	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	386	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCATGTACCGGATCTGCAAA	0.557000													11	30					4.3838e-07	5.16022e-07	1	1	0
NLRP4	147945	broad.mit.edu	37	19	56379120	56379120	+	Silent	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:56379120T>A	ENST00000301295.6	+	6	2654	c.2232T>A	c.(2230-2232)gcT>gcA	p.A744A	NLRP4_ENST00000587891.1_Silent_p.A669A|NLRP4_ENST00000346986.5_Intron	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	744							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAGTCCTTGCTGGCCTTCTAA	0.483000													35	103					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10935338	10935338	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:10935338C>A	ENST00000283141.6	+	21	2027	c.1731C>A	c.(1729-1731)aaC>aaA	p.N577K		NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	577						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AGCAAAATAACACCACATCTC	0.323000													37	44					3.62531e-18	5.71581e-18	1	1	0
MS4A10	341116	broad.mit.edu	37	11	60563027	60563027	+	Splice_Site	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:60563027G>T	ENST00000308287.1	+	6	588		c.e6-1			NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10							integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						TACCCTCTCAGGTCCACATCC	0.622000													6	19					5.9392e-07	6.9721e-07	1	1	0
SLC38A8	146167	broad.mit.edu	37	16	84056378	84056378	+	Splice_Site	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:84056378A>T	ENST00000299709.3	-	6	805		c.e6+1			NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8						amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GAAGGGCCTTACCCGTCAGTG	0.572000													11	24					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463163	224463163	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:224463163C>G	ENST00000305409.2	-	2	1070	c.838G>C	c.(838-840)Gat>Cat	p.D280H		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	280					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTCATCTCATCGTTGATTTGT	0.433000													41	225					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55816205	55816205	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:55816205G>T	ENST00000309383.1	+	14	1911	c.1634G>T	c.(1633-1635)gGg>gTg	p.G545V	BRSK1_ENST00000588584.1_3'UTR|BRSK1_ENST00000590333.1_Missense_Mutation_p.G561V|BRSK1_ENST00000326848.7_Missense_Mutation_p.G240V	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	545					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGTGGCGTCGGGGGAGCCGCC	0.701000													8	13					5.4927e-09	6.87782e-09	1	1	0
HNRNPU	3192	broad.mit.edu	37	1	245027246	245027246	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:245027246C>A	ENST00000444376.2	-	1	598	c.364G>T	c.(364-366)Gag>Tag	p.E122*	HNRNPU_ENST00000283179.9_Nonsense_Mutation_p.E122*	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	122	Asp/Glu-rich (acidic).				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TCCTCCTCCTCCATCGGGCCC	0.667000													5	36					0.0293803	0.0302198	1	1	0
LMO7	4008	broad.mit.edu	37	13	76432135	76432135	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:76432135C>T	ENST00000357063.3	+	31	6259	c.4999C>T	c.(4999-5001)Cat>Tat	p.H1667Y	LMO7_ENST00000605961.1_3'UTR|LMO7_ENST00000377534.3_3'UTR|LMO7_ENST00000465261.2_Missense_Mutation_p.H1382Y|LMO7_ENST00000341547.4_3'UTR|LMO7_ENST00000526202.1_3'UTR|LMO7_ENST00000321797.8_3'UTR			Q8WWI1	LMO7_HUMAN	LIM domain 7	0	LIM zinc-binding.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGTTGCTGCTCATGTAGATCT	0.378000													21	66					0	0	1	0	0
IFI44L	10964	broad.mit.edu	37	1	79093672	79093672	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:79093672G>T	ENST00000370751.4	+	2	251	c.72G>T	c.(70-72)ttG>ttT	p.L24F	IFI44L_ENST00000476521.1_Intron|IFI44L_ENST00000342282.3_Intron	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	24						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						ATGTTTCTTTGAGTCTTCTCT	0.363000													27	56					2.65835e-16	4.07236e-16	1	1	0
SPATA31D4	389761	broad.mit.edu	37	9	84549025	84549025	+	RNA	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:84549025C>A	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CCTTTAAGACCCAATGGAGGA	0.517000													5	11					0.014758	0.0153996	1	1	0
GRM8	2918	broad.mit.edu	37	7	126882809	126882809	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:126882809G>T	ENST00000339582.2	-	2	1258	c.450C>A	c.(448-450)gtC>gtA	p.V150V	GRM8_ENST00000358373.3_Silent_p.V150V|GRM8_ENST00000405249.1_Silent_p.V150V|GRM8_ENST00000444921.2_Silent_p.V150V			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	150					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CAGCACCTATGACGCCAGAAA	0.433000										HNSCC(24;0.065)			42	96					1.57019e-19	2.52165e-19	1	1	0
KCNT1	57582	broad.mit.edu	37	9	138678207	138678207	+	Silent	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:138678207G>C	ENST00000298480.5	+	29	3416	c.3342G>C	c.(3340-3342)cgG>cgC	p.R1114R	KCNT1_ENST00000486577.2_Silent_p.R1071R|KCNT1_ENST00000490355.2_Silent_p.R1092R|KCNT1_ENST00000371757.2_Silent_p.R1114R|KCNT1_ENST00000487664.1_Silent_p.R1069R|KCNT1_ENST00000491806.2_Silent_p.R1079R|KCNT1_ENST00000488444.2_Silent_p.R1093R|KCNT1_ENST00000263604.3_Silent_p.R1088R			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	1114						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AGTGGGCCCGGAGGCTGAGCC	0.761000													3	4					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181546975	181546975	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:181546975C>A	ENST00000526775.1	+	4	751	c.586C>A	c.(586-588)Cgg>Agg	p.R196R	CACNA1E_ENST00000358338.5_Silent_p.R147R|CACNA1E_ENST00000367570.1_Silent_p.R196R|CACNA1E_ENST00000357570.5_Silent_p.R147R|CACNA1E_ENST00000360108.3_Silent_p.R196R|CACNA1E_ENST00000367573.2_Silent_p.R196R|CACNA1E_ENST00000367567.4_5'UTR	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	196					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCGTGTCCTGCGGCCTTTGAA	0.542000													4	22					0.00909568	0.00958374	1	1	0
FOXI2	399823	broad.mit.edu	37	10	129535891	129535891	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:129535891G>A	ENST00000388920.4	+	1	393	c.354G>A	c.(352-354)gcG>gcA	p.A118A		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	118					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				TCCAGAGCGCGCCGCTGCGGA	0.657000													4	4					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	32902814	32902814	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:32902814G>T	ENST00000280979.4	+	2	285	c.115G>T	c.(115-117)Gga>Tga	p.G39*	AKAP6_ENST00000557272.1_Nonsense_Mutation_p.G39*|AKAP6_ENST00000554449.1_3'UTR|AKAP6_ENST00000557354.1_Nonsense_Mutation_p.G39*	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	39					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCAGGGTGAGGGAGAAGAGGC	0.552000													27	45					3.28513e-13	4.69925e-13	1	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319319	21319319	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:21319319A>T	ENST00000583088.1	+	3	1560	c.665A>T	c.(664-666)cAc>cTc	p.H222L	KCNJ12_ENST00000331718.5_Missense_Mutation_p.H222L	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CGCAAGAGCCACATTGTGGAG	0.642000										Prostate(3;0.18)			13	54					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65145388	65145388	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:65145388C>T	ENST00000371073.2	+	24	3355	c.3355C>T	c.(3355-3357)Cac>Tac	p.H1119Y	CACHD1_ENST00000290039.5_Missense_Mutation_p.H1068Y|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	1119					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TGCCTACCGCCACCAGATTCA	0.557000													26	53					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463340	224463340	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:224463340C>T	ENST00000305409.2	-	2	893	c.661G>A	c.(661-663)Gag>Aag	p.E221K		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	221					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTTTGCTCCTCATCCATCCTC	0.443000													52	179					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657960	72657960	+	RNA	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:72657960C>A	ENST00000425256.1	-	0	1951					NR_002164.1																						atgaaggagtcgatttcttcc	0.507000													32	80					5.71845e-15	8.60756e-15	1	1	0
PIK3AP1	118788	broad.mit.edu	37	10	98386627	98386627	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:98386627G>A	ENST00000339364.5	-	10	1626	c.1507C>T	c.(1507-1509)Cag>Tag	p.Q503*	PIK3AP1_ENST00000371109.3_Nonsense_Mutation_p.Q102*|PIK3AP1_ENST00000371110.2_Nonsense_Mutation_p.Q325*	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	503						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AGATGGCACTGATCTCTCTCC	0.517000													18	128					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211476985	211476985	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:211476985C>T	ENST00000233072.5	+	20	2732	c.2536C>T	c.(2536-2538)Cca>Tca	p.P846S	CPS1_ENST00000451903.2_Missense_Mutation_p.P395S|CPS1_ENST00000430249.2_Missense_Mutation_p.P852S	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	846					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTTGTCTGAACCAAGCAGCAC	0.438000													54	154					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20808037	20808037	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:20808037G>T	ENST00000601440.1	-	4	792	c.646C>A	c.(646-648)Ctt>Att	p.L216I	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGTCTAGTAAGGCTACAAGAG	0.388000													34	90					8.53417e-09	1.05941e-08	1	1	0
ROR2	4920	broad.mit.edu	37	9	94488832	94488832	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:94488832C>A	ENST00000375708.3	-	8	1575	c.1377G>T	c.(1375-1377)caG>caT	p.Q459H	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.Q319H	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	459					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCTGTTTGTGCTGGTTAATGA	0.517000													24	62					4.7796e-09	6.03739e-09	1	1	0
SLC9A2	6549	broad.mit.edu	37	2	103281574	103281574	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:103281574T>C	ENST00000233969.2	+	3	911	c.769T>C	c.(769-771)Ttc>Ctc	p.F257L		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	257						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GTACAACTTGTTCAAGTCGTT	0.453000													86	188					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50850488	50850488	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:50850488G>T	ENST00000404971.1	-	7	2536	c.1197C>A	c.(1195-1197)gcC>gcA	p.A399A	NRXN1_ENST00000406859.3_Silent_p.A366A|NRXN1_ENST00000402717.3_Silent_p.A366A|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Silent_p.A366A|NRXN1_ENST00000405472.3_Silent_p.A366A|NRXN1_ENST00000401669.2_Silent_p.A366A	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	366	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATCATGCCAGGCATTATCAT	0.463000													20	45					3.51602e-12	4.89974e-12	1	1	0
KEL	3792	broad.mit.edu	37	7	142638446	142638446	+	Missense_Mutation	SNP	G	G	T	rs1042015		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:142638446G>T	ENST00000355265.2	-	19	2566	c.2092C>A	c.(2092-2094)Cac>Aac	p.H698N		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	698					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					ACTCGGAGGTGTGGAGGGCTG	0.622000													36	64					1.59361e-14	2.36577e-14	1	1	0
POLD2	5425	broad.mit.edu	37	7	44154539	44154539	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:44154539C>T	ENST00000406581.2	-	12	1904	c.1255G>A	c.(1255-1257)Gag>Aag	p.E419K	POLD2_ENST00000223361.3_Missense_Mutation_p.E405K|POLD2_ENST00000452185.1_Missense_Mutation_p.E419K	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	419					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GTCTGGTCCTCAGGACCTGCA	0.557000													5	21					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48189064	48189064	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:48189064C>A	ENST00000080059.7	-	11	1186	c.1187G>T	c.(1186-1188)cGc>cTc	p.R396L	HDAC7_ENST00000427332.2_Missense_Mutation_p.R357L|HDAC7_ENST00000552960.1_Missense_Mutation_p.R379L|HDAC7_ENST00000354334.3_Missense_Mutation_p.R359L|HDAC7_ENST00000380610.4_Missense_Mutation_p.R413L	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	357	Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GGGCTCTGAGCGAGTCCGGCT	0.682000													25	57					9.57634e-11	1.28878e-10	1	1	0
SPATA31C1	441452	broad.mit.edu	37	9	90534071	90534071	+	RNA	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:90534071A>G	ENST00000602681.1	+	0	817																											CTCCCTGAGCAAGACAGACAG	0.562000													5	12					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13902233	13902233	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:13902233C>A	ENST00000265104.4	-	13	1763	c.1659G>T	c.(1657-1659)aaG>aaT	p.K553N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	553	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATCCATGAACTTCCGCAACT	0.308000									Kartagener syndrome				5	23					0.000602214	0.000660296	1	1	0
CLCA4	22802	broad.mit.edu	37	1	87045091	87045091	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:87045091C>A	ENST00000370563.3	+	13	2219	c.2177C>A	c.(2176-2178)aCc>aAc	p.T726N	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	726						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ACTCAGACCACCTTGGAGGAT	0.463000													23	69					5.35356e-11	7.27276e-11	1	1	0
GCNT4	51301	broad.mit.edu	37	5	74324736	74324736	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:74324736C>G	ENST00000322348.4	-	1	1988	c.1127G>C	c.(1126-1128)gGc>gCc	p.G376A		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	376					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		ATAGAAAAAGCCTTCATAGTA	0.453000													19	60					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175676257	175676257	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:175676257T>G	ENST00000409900.3	-	10	1259	c.946A>C	c.(946-948)Aag>Cag	p.K316Q	CHN1_ENST00000488080.1_5'UTR|CHN1_ENST00000409597.1_Missense_Mutation_p.K132Q|CHN1_ENST00000409156.3_Missense_Mutation_p.K290Q|CHN1_ENST00000295497.7_Missense_Mutation_p.K191Q	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	316	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			AAAGCCATCTTGACATCTTCA	0.323000			T	TAF15	extraskeletal myxoid chondrosarcoma								10	17					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664639	22664639	+	RNA	SNP	G	G	A	rs9306349	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr22:22664639G>A	ENST00000426066.1	+	0	820					NR_027293.1																						CCAGCCTTCTGTAACCCAGTA	0.428000													5	69					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76282203	76282203	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:76282203G>T	ENST00000263187.3	+	6	1065	c.961G>T	c.(961-963)Gaa>Taa	p.E321*		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	321					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						CCAAAACCTTGAATTGTTAAT	0.274000								Mismatch excision repair (MMR)					17	44					1.02788e-11	1.4278e-11	1	1	0
DSCAML1	57453	broad.mit.edu	37	11	117299329	117299329	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:117299329C>A	ENST00000321322.6	-	33	6058	c.6057G>T	c.(6055-6057)ggG>ggT	p.G2019G	DSCAML1_ENST00000527706.1_Silent_p.G1749G	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1959					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGCGGGGGCCCCTGGGTGGG	0.721000													4	9					0.184627	0.185486	1	1	0
TMLHE	55217	broad.mit.edu	37	X	154754267	154754267	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:154754267G>C	ENST00000334398.3	-	3	353	c.208C>G	c.(208-210)Cgc>Ggc	p.R70G	TMLHE-AS1_ENST00000452506.1_RNA|TMLHE_ENST00000369439.4_Missense_Mutation_p.R70G	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	70					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	TAATCAAAGCGCATCACGGTA	0.428000													45	43					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14589180	14589180	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:14589180C>T	ENST00000544627.1	+	4	2130	c.1810C>T	c.(1810-1812)Caa>Taa	p.Q604*	ATF7IP_ENST00000543189.1_Nonsense_Mutation_p.Q595*|ATF7IP_ENST00000536444.1_Nonsense_Mutation_p.Q595*|ATF7IP_ENST00000540793.1_Nonsense_Mutation_p.Q596*|ATF7IP_ENST00000261168.4_Nonsense_Mutation_p.Q596*|ATF7IP_ENST00000541654.1_3'UTR			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	596	Interaction with SETDB1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						CCAGAAACTTCAAAAGGTATT	0.318000													34	131					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045092	87045092	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:87045092C>A	ENST00000370563.3	+	13	2220	c.2178C>A	c.(2176-2178)acC>acA	p.T726T	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	726						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CTCAGACCACCTTGGAGGATT	0.468000													23	67					1.10923e-09	1.4477e-09	1	1	0
FBXO4	26272	broad.mit.edu	37	5	41939543	41939543	+	Splice_Site	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:41939543G>T	ENST00000281623.3	+	6	955	c.898_splice	c.e6-1	p.R300_splice	FBXO4_ENST00000509134.1_Intron	NM_012176.2	NP_036308.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	300					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				CATTCCTTAGGACATGAATGG	0.318000													45	157					2.65591e-33	4.82081e-33	1	1	0
LIPJ	142910	broad.mit.edu	37	10	90353863	90353863	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:90353863G>C	ENST00000371939.3	+	5	605	c.291G>C	c.(289-291)ttG>ttC	p.L97F		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	97					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		GGAAACACTTGTACCTAGAAA	0.373000													20	66					0	0	1	0	0
CLN5	1203	broad.mit.edu	37	13	77570219	77570219	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:77570219C>T	ENST00000377453.3	+	3	1961	c.669C>T	c.(667-669)caC>caT	p.H223H	CLN5_ENST00000485938.1_3'UTR	NM_006493.2	NP_006484.1	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	174					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		ATGATGTTCACTGGAAGGAAA	0.393000													60	177					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37343119	37343119	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:37343119G>A	ENST00000394303.3	-	5	685	c.478C>T	c.(478-480)Ccc>Tcc	p.P160S	CACNB1_ENST00000582877.1_5'UTR|CACNB1_ENST00000344140.5_Missense_Mutation_p.P160S|CACNB1_ENST00000394310.3_Missense_Mutation_p.P160S	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	160	SH3.				axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	ACGGGGCTGGGAATGAAGCCA	0.587000													20	53					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59108330	59108330	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:59108330G>A	ENST00000395153.3	+	3	646	c.499G>A	c.(499-501)Ggg>Agg	p.G167R	DACT1_ENST00000335867.4_Missense_Mutation_p.G167R|DACT1_ENST00000555845.1_3'UTR|DACT1_ENST00000541264.2_5'UTR|DACT1_ENST00000395151.3_Intron|DACT1_ENST00000556859.1_5'UTR	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	167					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCTGAGTGATGGGGCTTCAGG	0.423000													49	121					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45094950	45094950	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr21:45094950A>T	ENST00000340648.4	+	6	572	c.455A>T	c.(454-456)gAg>gTg	p.E152V		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	152					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		CTGATGAAGGAGGTCCTGTGT	0.473000													72	167					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120844793	120844793	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:120844793G>C	ENST00000263713.5	+	11	1064	c.850G>C	c.(850-852)Gtg>Ctg	p.V284L	EPB41L5_ENST00000331393.4_Missense_Mutation_p.V284L|EPB41L5_ENST00000443124.1_Missense_Mutation_p.V284L|EPB41L5_ENST00000452780.1_Missense_Mutation_p.V284L|EPB41L5_ENST00000443902.2_Missense_Mutation_p.V284L	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	284	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						ATTAACCTTGGTGGTTGTAGA	0.289000													24	68					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7701122	7701122	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:7701122G>T	ENST00000572933.1	+	53	9665	c.8205G>T	c.(8203-8205)gtG>gtT	p.V2735V	DNAH2_ENST00000389173.2_Silent_p.V2735V			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2735	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGCAGCTAGTGCTCTTCCGAG	0.512000													53	92					2.40265e-35	4.37951e-35	1	1	0
KEAP1	9817	broad.mit.edu	37	19	10600428	10600428	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:10600428C>A	ENST00000171111.5	-	4	1974	c.1427G>T	c.(1426-1428)gGg>gTg	p.G476V	KEAP1_ENST00000393623.2_Missense_Mutation_p.G476V	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GTCAAAGCCCCCCACGGCATA	0.567000													21	27					3.8784e-16	5.89954e-16	1	1	0
COIL	8161	broad.mit.edu	37	17	55027940	55027940	+	Silent	SNP	A	A	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:55027940A>C	ENST00000240316.4	-	2	697	c.663T>G	c.(661-663)ggT>ggG	p.G221G		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	221						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTCTAGCAGAACCTTTTGGAG	0.428000													39	106					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50988042	50988042	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr22:50988042C>A	ENST00000395676.2	+	1	1581	c.1447C>A	c.(1447-1449)Cgg>Agg	p.R483R		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	483										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCCAGCCACCGGCGTTCCAG	0.657000													21	72					3.01185e-09	3.82682e-09	1	1	0
NAV3	89795	broad.mit.edu	37	12	78515820	78515820	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:78515820C>A	ENST00000397909.2	+	16	4023	c.3850C>A	c.(3850-3852)Cgg>Agg	p.R1284R	NAV3_ENST00000228327.6_Silent_p.R1284R|NAV3_ENST00000266692.7_Intron|NAV3_ENST00000536525.2_Silent_p.R1284R			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1284	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CACATTAGCGCGGCAAGGCAG	0.567000										HNSCC(70;0.22)			16	36					1.5739e-10	2.10503e-10	1	1	0
SEL1L	6400	broad.mit.edu	37	14	81964777	81964777	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:81964777T>C	ENST00000336735.4	-	9	1069	c.953A>G	c.(952-954)tAt>tGt	p.Y318C		NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	318	Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		AACAAGACGATAGTGAGTCAG	0.393000													20	65					0	0	1	0	0
TMEM169	92691	broad.mit.edu	37	2	216960741	216960741	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:216960741G>T	ENST00000454545.1	+	3	381	c.55G>T	c.(55-57)Ggc>Tgc	p.G19C	TMEM169_ENST00000406027.2_Missense_Mutation_p.G19C|TMEM169_ENST00000437356.2_Missense_Mutation_p.G19C|TMEM169_ENST00000295658.4_Missense_Mutation_p.G19C	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	19						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCCACCAGGGCTCTCTCAG	0.542000													19	66					3.32936e-07	3.9405e-07	1	1	0
DMD	1756	broad.mit.edu	37	X	31986631	31986631	+	Splice_Site	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:31986631C>G	ENST00000357033.4	-	45	6645	c.6438_splice	c.e45-1	p.E2147_splice	DMD_ENST00000378677.2_Splice_Site_p.E2143_splice|DMD_ENST00000359836.1_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000343523.2_5'UTR|DMD_ENST00000474231.1_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2147					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCCTGGAGTTCCTGTAAGATA	0.403000													18	18					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88726682	88726682	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:88726682C>A	ENST00000394480.1	-	5	683	c.362G>T	c.(361-363)aGa>aTa	p.R121I	NTRK3_ENST00000540489.2_Missense_Mutation_p.R121I|NTRK3_ENST00000360948.2_Missense_Mutation_p.R121I|NTRK3_ENST00000357724.2_Missense_Mutation_p.R121I|NTRK3_ENST00000558676.1_Missense_Mutation_p.R121I|NTRK3_ENST00000317501.3_Missense_Mutation_p.R121I|NTRK3_ENST00000542733.2_Missense_Mutation_p.R23I|NTRK3_ENST00000355254.2_Missense_Mutation_p.R121I|NTRK3_ENST00000557856.1_Missense_Mutation_p.R121I	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	121					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCAAAGGCTCTGGGCTGAAT	0.542000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			38	96					3.76604e-16	5.74886e-16	1	1	0
WSCD2	9671	broad.mit.edu	37	12	108604049	108604049	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:108604049C>A	ENST00000332082.4	+	5	1467	c.649C>A	c.(649-651)Cgg>Agg	p.R217R	WSCD2_ENST00000547525.1_Silent_p.R217R|WSCD2_ENST00000549903.1_Silent_p.R217R|WSCD2_ENST00000261400.3_Silent_p.R217R			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	217	WSC 1.					integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CTCTGTCTACCGGCTGCAGCT	0.672000													3	12					0.00024832	0.000274359	1	1	0
BUB1	699	broad.mit.edu	37	2	111395737	111395737	+	Splice_Site	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:111395737C>T	ENST00000535254.1	-	24	3070		c.e24-1		BUB1_ENST00000302759.6_Splice_Site|BUB1_ENST00000409311.1_Splice_Site	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase						apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATGAGGAAGCCTGAAAAAGAC	0.378000													4	19					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347244	48347244	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:48347244G>T	ENST00000319856.4	+	1	773	c.752G>T	c.(751-753)aGg>aTg	p.R251M		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TACTCCTTGAGGTCCCACAGT	0.488000													9	113					5.16669e-11	7.04104e-11	1	1	0
OR2M2	391194	broad.mit.edu	37	1	248343361	248343361	+	Missense_Mutation	SNP	C	C	A	rs146796261		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:248343361C>A	ENST00000359682.2	+	1	74	c.74C>A	c.(73-75)aCg>aAg	p.T25K		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCACCACACACGTTCCTCTTC	0.498000													94	486					2.56585e-57	4.77778e-57	1	1	0
PDZD2	23037	broad.mit.edu	37	5	32087673	32087673	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:32087673C>T	ENST00000438447.1	+	20	4507	c.4119C>T	c.(4117-4119)tcC>tcT	p.S1373S	PDZD2_ENST00000282493.3_Silent_p.S1373S			O15018	PDZD2_HUMAN	PDZ domain containing 2	1373					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTGAAAGCTCCCAGGAGCCTT	0.577000													3	22					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48416571	48416571	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:48416571C>A	ENST00000249598.1	-	1	282	c.123G>T	c.(121-123)ctG>ctT	p.L41L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	41					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CAGGCACCCCCAGTGGGCTGT	0.637000													12	28					1.08611e-07	1.31061e-07	1	1	0
NEK10	152110	broad.mit.edu	37	3	27346453	27346453	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:27346453C>T	ENST00000429845.2	-	13	1175	c.813G>A	c.(811-813)gcG>gcA	p.A271A	NEK10_ENST00000341435.5_Silent_p.A271A			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	271							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCAGCAACTCCGCTGTTAGTC	0.493000													6	16					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906879	23906879	+	Silent	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:23906879T>A	ENST00000382298.3	-	10	11724	c.11136A>T	c.(11134-11136)acA>acT	p.T3712T	SACS_ENST00000402364.1_Silent_p.T2962T|SACS_ENST00000382292.3_Silent_p.T3712T	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3712					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGCTTAAGGGTGTAGCTTTCT	0.393000													38	106					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729780	62729780	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:62729780G>T	ENST00000349451.3	+	6	1153	c.741G>T	c.(739-741)ctG>ctT	p.L247L	OPRL1_ENST00000336866.2_Silent_p.L247L|OPRL1_ENST00000355631.4_Silent_p.L247L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	247					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GAGTCCGCCTGCTCTCGGGCT	0.627000													28	95					7.38237e-10	9.66419e-10	1	1	0
MORC1	27136	broad.mit.edu	37	3	108836879	108836879	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:108836879G>T	ENST00000232603.5	-	1	110	c.28C>A	c.(28-30)Cgg>Agg	p.R10R	MORC1_ENST00000483760.1_Silent_p.R10R	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	10					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGCTGGGCCCGCTGAAGCGCA	0.662000													3	11					0.004672	0.00494682	1	1	0
TMOD1	7111	broad.mit.edu	37	9	100326390	100326390	+	Silent	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:100326390G>C	ENST00000395211.2	+	6	694	c.558G>C	c.(556-558)acG>acC	p.T186T	TMOD1_ENST00000259365.3_Silent_p.T186T|TMOD1_ENST00000375175.1_Silent_p.T59T	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	186					muscle filament sliding	cytosol	actin binding	p.T186T(1)		breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TAGAGGAAACGCTGGAACGGA	0.463000													11	21					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102337206	102337206	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:102337206G>A	ENST00000395065.3	-	9	968	c.867C>T	c.(865-867)ttC>ttT	p.F289F	NXF3_ENST00000425463.2_Silent_p.F200F|NXF3_ENST00000425644.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	289						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						AGGTATCCGAGAAGGTCGTGC	0.547000													75	64					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15215662	15215662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:15215662G>A	ENST00000395930.1	-	7	1201	c.1015C>T	c.(1015-1017)Caa>Taa	p.Q339*	TEKT3_ENST00000338696.2_Nonsense_Mutation_p.Q339*	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	339					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TTGTTGAATTGATTCCACATC	0.448000													25	113					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53014175	53014175	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:53014175G>T	ENST00000421239.2	+	6	785	c.541G>T	c.(541-543)Gag>Tag	p.E181*		NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TAATCAAGTGGAGAAGTCTGT	0.373000													66	154					4.13886e-29	7.23882e-29	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766737	77766737	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:77766737C>A	ENST00000521891.2	+	10	8028	c.7580C>A	c.(7579-7581)cCg>cAg	p.P2527Q	ZFHX4_ENST00000050961.6_Missense_Mutation_p.P2482Q|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P2501Q|ZFHX4_ENST00000455469.2_Missense_Mutation_p.P2482Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2482						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTCACTCTCCGTTCTTGGAA	0.507000										HNSCC(33;0.089)			42	188					4.01765e-15	6.06862e-15	1	1	0
SMYD2	56950	broad.mit.edu	37	1	214488167	214488167	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:214488167G>T	ENST00000366957.5	+	3	322	c.300G>T	c.(298-300)tgG>tgT	p.W100C	SMYD2_ENST00000415093.2_Missense_Mutation_p.W100C|SMYD2_ENST00000491455.1_3'UTR	NM_020197.2	NP_064582.2	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	100					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		GGGAAAACTGGAATCCCTCGG	0.383000													20	105					1.85244e-09	2.41041e-09	1	1	0
MT4	84560	broad.mit.edu	37	16	56602768	56602768	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:56602768G>T	ENST00000219162.3	+	3	193	c.113G>T	c.(112-114)tGc>tTc	p.C38F		NM_032935.2	NP_116324.1	P47944	MT4_HUMAN	metallothionein 4	38						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						TGTCCCTGCTGCCCCCCGGGC	0.602000													56	158					1.31171e-36	2.40109e-36	1	1	0
NCKAP5L	57701	broad.mit.edu	37	12	50190889	50190889	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:50190889C>A	ENST00000335999.6	-	8	955	c.754G>T	c.(754-756)Gga>Tga	p.G252*		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	248	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						AGCAGGCCTCCCAGGTTGCCA	0.716000													5	7					0.184627	0.185486	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40367780	40367780	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:40367780C>A	ENST00000221347.6	-	29	13187	c.13180G>T	c.(13180-13182)Ggt>Tgt	p.G4394C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4394	TIL 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AACACGAAACCCGCGTCGCAC	0.657000													16	33					3.70931e-20	5.97919e-20	1	1	0
SARDH	1757	broad.mit.edu	37	9	136596590	136596590	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:136596590C>T	ENST00000371872.4	-	4	784	c.527G>A	c.(526-528)gGt>gAt	p.G176D	SARDH_ENST00000422262.2_Missense_Mutation_p.G8D|SARDH_ENST00000298628.5_Missense_Mutation_p.G176D|SARDH_ENST00000371867.1_Missense_Mutation_p.G87D|SARDH_ENST00000439388.1_Missense_Mutation_p.G176D	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	176					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GGATTCCACACCATACGCCTT	0.632000													12	48					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10079461	10079461	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:10079461C>A	ENST00000382452.2	-	13	1767	c.1485G>T	c.(1483-1485)gtG>gtT	p.V495V	WDR1_ENST00000382451.2_Silent_p.V355V|WDR1_ENST00000499869.2_Silent_p.V495V|WDR1_ENST00000515743.1_5'UTR|WDR1_ENST00000502702.1_Silent_p.V355V	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	495					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		GGGAGTAGGCCACGTCGGTCA	0.667000													6	9					0.0293803	0.0302198	1	1	0
METTL10	399818	broad.mit.edu	37	10	126477722	126477722	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:126477722C>A	ENST00000368836.2	-	3	217	c.181G>T	c.(181-183)Gga>Tga	p.G61*	RP11-12J10.3_ENST00000494792.1_Missense_Mutation_p.L25F	NM_212554.2	NP_997719.2	Q5JPI9	MTL10_HUMAN	methyltransferase like 10	61							methyltransferase activity			endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5		all_lung(145;0.0186)|Lung NSC(174;0.0295)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.101)|COAD - Colon adenocarcinoma(40;0.111)		CTCTCTTCTCCAAACCTGTTA	0.378000													12	68					6.40141e-05	7.16427e-05	1	1	0
MED16	10025	broad.mit.edu	37	19	885978	885978	+	Missense_Mutation	SNP	C	C	T	rs137978287		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:885978C>T	ENST00000312090.6	-	5	821	c.671G>A	c.(670-672)gGc>gAc	p.G224D	MED16_ENST00000325464.1_Missense_Mutation_p.G224D|MED16_ENST00000269814.4_Missense_Mutation_p.G224D|MED16_ENST00000606828.1_Intron|MED16_ENST00000395808.3_Missense_Mutation_p.G224D|MED16_ENST00000589119.1_Missense_Mutation_p.G224D			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	224					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGATGTTGCCGCCGCCGGT	0.701000													19	23					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28387460	28387460	+	Missense_Mutation	SNP	C	C	A	rs143615465	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:28387460C>A	ENST00000261609.7	-	76	11732	c.11624G>T	c.(11623-11625)cGg>cTg	p.R3875L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3875					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCAGTACCTCCGGAACCAGGC	0.532000													19	35					4.96729e-08	6.02772e-08	1	1	0
TCAIM	285343	broad.mit.edu	37	3	44408980	44408980	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:44408980A>G	ENST00000342649.4	+	5	779	c.352A>G	c.(352-354)Aga>Gga	p.R118G	TCAIM_ENST00000417237.1_Missense_Mutation_p.R118G	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		TTTGCACACCAGAGATCTGCT	0.333000													30	85					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561239	51561239	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:51561239C>T	ENST00000298355.3	-	1	1540	c.419G>A	c.(418-420)cGg>cAg	p.R140Q	TRIM9_ENST00000338969.5_Missense_Mutation_p.R140Q|TRIM9_ENST00000360392.4_Missense_Mutation_p.R140Q	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	140					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GCGGAGCCCCCGGTCATCCAG	0.667000													11	13					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58131812	58131812	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:58131812G>T	ENST00000396161.5	+	3	635	c.325G>T	c.(325-327)Gat>Tat	p.D109Y	ZNF134_ENST00000597975.1_3'UTR	NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	109						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CTTAAGAAGGGATAAAAGTGA	0.448000													21	61					2.4624e-09	3.15654e-09	1	1	0
RYR2	6262	broad.mit.edu	37	1	237660050	237660050	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:237660050C>T	ENST00000366574.2	+	20	2518	c.2201C>T	c.(2200-2202)tCa>tTa	p.S734L	RYR2_ENST00000542537.1_Missense_Mutation_p.S718L|RYR2_ENST00000360064.6_Missense_Mutation_p.S732L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	734	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATCTCTGGTCAGGTACGTAC	0.468000													88	219					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109687433	109687433	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:109687433G>A	ENST00000277225.5	+	3	1529	c.1240G>A	c.(1240-1242)Gag>Aag	p.E414K	ZNF462_ENST00000457913.1_Missense_Mutation_p.E414K			Q96JM2	ZN462_HUMAN	zinc finger protein 462	414					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCTGTCTGCAGAGCAGCTGAT	0.433000													37	99					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561238	51561238	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:51561238C>A	ENST00000298355.3	-	1	1541	c.420G>T	c.(418-420)cgG>cgT	p.R140R	TRIM9_ENST00000338969.5_Silent_p.R140R|TRIM9_ENST00000360392.4_Silent_p.R140R	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	140					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					CGCGGAGCCCCCGGTCATCCA	0.667000													10	13					0.000673444	0.000736526	1	1	0
OR2T4	127074	broad.mit.edu	37	1	248524936	248524936	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:248524936G>A	ENST00000366475.1	+	1	54	c.54G>A	c.(52-54)ctG>ctA	p.L18L		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTTCATCCTGATGGGACTCT	0.488000													18	84					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46916243	46916243	+	Silent	SNP	G	G	A	rs141108617		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:46916243G>A	ENST00000378623.1	-	12	1679	c.1437C>T	c.(1435-1437)cgC>cgT	p.R479R		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	479					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		AGACAAGCTCGCGGCGGTGGT	0.587000													21	46					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49585780	49585780	+	Splice_Site	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:49585780C>A	ENST00000371175.4	-	3	519		c.e3+1		RHAG_ENST00000229810.7_Splice_Site	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein						carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					CTAACTCTTACCTTAAATATT	0.383000													23	29					2.21704e-12	3.10961e-12	1	1	0
ZNF730	100129543	broad.mit.edu	37	19	23329335	23329335	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:23329335A>T	ENST00000597761.2	+	4	1688	c.1489A>T	c.(1489-1491)Agg>Tgg	p.R497W		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						ACACCTTACTAGGCATAAGAC	0.338000													7	20					0	0	1	0	0
PIGN	23556	broad.mit.edu	37	18	59756056	59756056	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr18:59756056G>C	ENST00000357637.5	-	25	2718	c.2303C>G	c.(2302-2304)tCt>tGt	p.S768C	PIGN_ENST00000400334.3_Missense_Mutation_p.S768C	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	768					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				AGTATTATAAGAGAACTGGAT	0.353000													3	3					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17559430	17559430	+	Silent	SNP	C	C	T	rs142341928		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:17559430C>T	ENST00000375471.4	+	11	1370	c.1278C>T	c.(1276-1278)ccC>ccT	p.P426P		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	426					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	CGGAATACCCCCTGGGCCGGA	0.672000													5	16					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656543	19656543	+	Silent	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:19656543T>C	ENST00000586018.1	+	8	3309	c.3207T>C	c.(3205-3207)acT>acC	p.T1069T	CILP2_ENST00000291495.4_Silent_p.T1063T			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1063						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCGTCTACACTGTCACTGACC	0.637000													7	21					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53568929	53568929	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:53568929C>T	ENST00000025008.5	-	15	3983	c.3460G>A	c.(3460-3462)Gaa>Aaa	p.E1154K	RB1CC1_ENST00000435644.2_Missense_Mutation_p.E1154K|RB1CC1_ENST00000539297.1_Missense_Mutation_p.E1154K|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1154					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TTGTTTAATTCAGCTTTAAGT	0.294000													10	63					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281831	152281831	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:152281831C>A	ENST00000368799.1	-	3	5566	c.5531G>T	c.(5530-5532)aGc>aTc	p.S1844I	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1844	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGGTGTGGCTGTGATGAGA	0.542000									Ichthyosis				165	771					6.26973e-84	1.17762e-83	1	1	0
TJP2	9414	broad.mit.edu	37	9	71851089	71851089	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:71851089G>A	ENST00000377245.4	+	13	2134	c.1926G>A	c.(1924-1926)ctG>ctA	p.L642L	TJP2_ENST00000265384.7_Silent_p.L642L|TJP2_ENST00000539225.1_Silent_p.L673L|TJP2_ENST00000348208.4_Silent_p.L642L|TJP2_ENST00000535702.1_Silent_p.L646L|TJP2_ENST00000453658.2_Silent_p.L619L	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	642	SH3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						ACGGCAAGCTGGGCAACTGGC	0.507000													32	82					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35743657	35743657	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:35743657C>A	ENST00000400441.3	-	19	2453	c.2454G>T	c.(2452-2454)caG>caT	p.Q818H	MROH8_ENST00000217333.8_Missense_Mutation_p.Q647H|MROH8_ENST00000441008.2_Missense_Mutation_p.Q804H					maestro heat-like repeat family member 8																		GCAGGAGTATCTGGATGGCTG	0.468000													73	165					2.10328e-26	3.59138e-26	1	1	0
OR5H1	26341	broad.mit.edu	37	3	97852052	97852052	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:97852052T>G	ENST00000354565.2	+	1	511	c.511T>G	c.(511-513)Tcc>Gcc	p.S171A	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						CTTCTGTAACTCCAACATAGT	0.338000													14	75					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25919606	25919606	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:25919606C>A	ENST00000398988.3	+	10	1287	c.842C>A	c.(841-843)gCa>gAa	p.A281E	KSR1_ENST00000581975.1_3'UTR|KSR1_ENST00000319524.6_Missense_Mutation_p.A418E|KSR1_ENST00000268763.6_Missense_Mutation_p.A281E|KSR1_ENST00000509603.2_Missense_Mutation_p.A418E	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	416					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GTGGACAGAGCAGCCGAACCC	0.552000													8	30					5.4927e-09	6.87782e-09	1	1	0
KIAA1958	158405	broad.mit.edu	37	9	115337246	115337246	+	Missense_Mutation	SNP	C	C	T	rs61910738	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:115337246C>T	ENST00000337530.6	+	2	1182	c.886C>T	c.(886-888)Ccc>Tcc	p.P296S	KIAA1958_ENST00000536272.1_Missense_Mutation_p.P296S|KIAA1958_ENST00000374244.3_Missense_Mutation_p.P296S	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	296										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						AAACAGAGGACCCCCTGGTAC	0.537000													87	244					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766841	77766841	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:77766841C>T	ENST00000521891.2	+	10	8132	c.7684C>T	c.(7684-7686)Cag>Tag	p.Q2562*	ZFHX4_ENST00000050961.6_Nonsense_Mutation_p.Q2517*|ZFHX4_ENST00000518282.1_Nonsense_Mutation_p.Q2536*|ZFHX4_ENST00000455469.2_Nonsense_Mutation_p.Q2517*	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2517						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATGCCCCCTCAGGCCAGTTC	0.498000										HNSCC(33;0.089)			22	87					0	0	1	0	0
INPP5A	3632	broad.mit.edu	37	10	134591206	134591206	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:134591206G>A	ENST00000368594.3	+	13	1286	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K	INPP5A_ENST00000368593.3_Missense_Mutation_p.E337K	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	337					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CCGCCAGGGTGAGCAGTACAT	0.672000													13	56					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109687463	109687463	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:109687463T>A	ENST00000277225.5	+	3	1559	c.1270T>A	c.(1270-1272)Tta>Ata	p.L424I	ZNF462_ENST00000457913.1_Missense_Mutation_p.L424I			Q96JM2	ZN462_HUMAN	zinc finger protein 462	424					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TGGCAACAAATTATTGGAGAC	0.453000													44	83					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88126413	88126413	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:88126413G>T	ENST00000507897.1	+	6	582	c.499G>T	c.(499-501)Gca>Tca	p.A167S	C6ORF165_ENST00000369562.4_Missense_Mutation_p.A167S			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	167										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTTTCCTCAGGCAGAGCTTGG	0.338000													9	29					1.76689e-08	2.16846e-08	1	1	0
TSHB	7252	broad.mit.edu	37	1	115576762	115576762	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:115576762G>C	ENST00000256592.1	+	3	399	c.331G>C	c.(331-333)Gac>Cac	p.D111H	TSHB_ENST00000369517.1_Missense_Mutation_p.D111H	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	111					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		GTGCAATACTGACTATAGTGA	0.398000													76	180					0	0	1	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134488118	134488118	+	Silent	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:134488118C>G	ENST00000319914.5	-	4	1177	c.150G>C	c.(148-150)ctG>ctC	p.L50L	ST3GAL1_ENST00000399640.2_Silent_p.L50L|ST3GAL1_ENST00000522652.1_Silent_p.L50L|ST3GAL1_ENST00000521180.1_Silent_p.L50L			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	50					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TCAGTCTCTTCAGGTTCTCGG	0.577000													17	66					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79029306	79029306	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:79029306T>C	ENST00000446378.2	+	2	4749	c.4718T>C	c.(4717-4719)tTg>tCg	p.L1573S		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1573						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TCTCCTGAGTTGGAAAATTTA	0.423000													68	163					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138377866	138377866	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:138377866G>T	ENST00000356818.2	+	4	2059	c.1510G>T	c.(1510-1512)Ggg>Tgg	p.G504W	PPP1R26_ENST00000605660.1_Missense_Mutation_p.G504W|PPP1R26_ENST00000605286.1_Missense_Mutation_p.G504W|PPP1R26_ENST00000604351.1_Missense_Mutation_p.G504W|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Missense_Mutation_p.G504W	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	504						nucleolus	protein binding										GGGCAGTGACGGGTCCCTGTC	0.622000													14	42					4.93089e-13	7.03018e-13	1	1	0
MEGF6	1953	broad.mit.edu	37	1	3416172	3416172	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:3416172C>T	ENST00000356575.4	-	23	3171	c.2945G>A	c.(2944-2946)cGg>cAg	p.R982Q	MEGF6_ENST00000294599.4_Missense_Mutation_p.R877Q	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	982	EGF-like 17.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCGGGGGCCCCGGCGGCCAGC	0.697000													2	4					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314284	54314284	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:54314284G>C	ENST00000324134.6	-	3	797	c.629C>G	c.(628-630)cCg>cGg	p.P210R	NLRP12_ENST00000535162.1_Missense_Mutation_p.P210R|NLRP12_ENST00000354278.3_Missense_Mutation_p.P210R|NLRP12_ENST00000351894.4_Missense_Mutation_p.P210R|NLRP12_ENST00000345770.5_Missense_Mutation_p.P210R|NLRP12_ENST00000391772.1_Missense_Mutation_p.P210R|NLRP12_ENST00000391775.3_Missense_Mutation_p.P210R|NLRP12_ENST00000391773.1_Missense_Mutation_p.P210R	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	210					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding	p.P210R(1)		NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CACGGTGCGCGGTGGCTCGGG	0.647000													26	71					0	0	1	0	0
COX20	116228	broad.mit.edu	37	1	245005304	245005304	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:245005304T>C	ENST00000411948.2	+	2	494	c.101T>C	c.(100-102)aTa>aCa	p.I34T	COX20_ENST00000498262.1_3'UTR|COX20_ENST00000366528.3_Missense_Mutation_p.I46T	NM_198076.4	NP_932342.1	Q5RI15	FA36A_HUMAN	COX20 cytochrome C oxidase assembly factor	34						integral to membrane											CGGCATTCAATATTGTATGGT	0.343000													21	104					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184290625	184290625	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:184290625C>T	ENST00000330394.2	+	3	969	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	173						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GGATGCCGGCCGTGTCAACAC	0.622000													23	47					0	0	1	0	0
CSN3	1448	broad.mit.edu	37	4	71115171	71115171	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:71115171G>T	ENST00000304954.3	+	4	630	c.544G>T	c.(544-546)Gca>Tca	p.A182S		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	182						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TCCACCTACGGCATAAAAACA	0.413000													13	31					8.60227e-14	1.24287e-13	1	1	0
CUBN	8029	broad.mit.edu	37	10	17110718	17110718	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:17110718T>A	ENST00000377833.4	-	20	2742	c.2677A>T	c.(2677-2679)Aca>Tca	p.T893S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	893	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGTATGTCTGTACCGCAATAC	0.313000													44	132					0	0	1	0	0
PLA2G2D	26279	broad.mit.edu	37	1	20440644	20440644	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:20440644C>A	ENST00000375105.3	-	4	459	c.401G>T	c.(400-402)tGg>tTg	p.W134L		NM_012400.2	NP_036532.1	Q9UNK4	PA2GD_HUMAN	phospholipase A2, group IID	134					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000798)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGGGCCGCCAGTAGAAACG	0.612000										Multiple Myeloma(11;0.12)			11	28					2.80697e-09	3.57703e-09	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2807848	2807848	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:2807848C>T	ENST00000602557.1	-	68	10777	c.10222G>A	c.(10222-10224)Gag>Aag	p.E3408K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E3230K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E3407K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E3231K|CSMD1_ENST00000520002.1_Missense_Mutation_p.E3408K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E3231K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3408						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTGGGCCTCCTCCTTCTTG	0.398000													101	136					0	0	1	0	0
ORC4	5000	broad.mit.edu	37	2	148731062	148731062	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:148731062C>A	ENST00000535373.1	-	4	521	c.89G>T	c.(88-90)cGt>cTt	p.R30L	ORC4_ENST00000392857.4_Missense_Mutation_p.R30L|ORC4_ENST00000542387.1_5'UTR|ORC4_ENST00000540442.1_5'UTR|ORC4_ENST00000536575.1_Intron|ORC4_ENST00000264169.2_Missense_Mutation_p.R30L|ORC4_ENST00000392858.1_Missense_Mutation_p.R30L	NM_001190879.2	NP_001177808.1	O43929	ORC4_HUMAN	origin recognition complex, subunit 4	30					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	14						TGGACTCTGACGACAAAATCT	0.318000													24	101					7.76418e-22	1.28511e-21	1	1	0
REPIN1	29803	broad.mit.edu	37	7	150069332	150069332	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:150069332C>A	ENST00000397281.2	+	4	1491	c.1002C>A	c.(1000-1002)gcC>gcA	p.A334A	RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000489432.2_Silent_p.A391A|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000425389.2_Silent_p.A334A|REPIN1_ENST00000444957.1_Silent_p.A334A|REPIN1_ENST00000540729.1_Silent_p.A334A	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	334	Pro-rich.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGCTGCCAGCCGGCCCCCAGG	0.746000													3	4					1	1	1	1	0
USP4	7375	broad.mit.edu	37	3	49362339	49362339	+	Silent	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:49362339T>C	ENST00000351842.4	-	5	629	c.621A>G	c.(619-621)ctA>ctG	p.L207L	USP4_ENST00000415188.1_Silent_p.L207L|USP4_ENST00000416417.1_Silent_p.L207L|USP4_ENST00000265560.4_Silent_p.L207L	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	207					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GACCCTGGTATAGCCCAGCAT	0.547000													43	135					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111430530	111430530	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:111430530T>G	ENST00000428084.1	-	31	3570	c.3298A>C	c.(3298-3300)Agt>Cgt	p.S1100R	DOCK4_ENST00000437633.1_Missense_Mutation_p.S1100R			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1100	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				AAGTTGCCACTCCGCCTCTGC	0.473000													10	47					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432982	30432982	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:30432982C>A	ENST00000375978.3	-	1	438	c.364G>T	c.(364-366)Ggc>Tgc	p.G122C		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	122					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CCCCGGGTGCCCTCAGCACCT	0.706000													8	11					0.00448238	0.00478121	1	1	0
CDH18	1016	broad.mit.edu	37	5	19503128	19503128	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:19503128G>T	ENST00000507958.1	-	13	2593	c.1603C>A	c.(1603-1605)Cca>Aca	p.P535T	CDH18_ENST00000506372.1_Missense_Mutation_p.P535T|CDH18_ENST00000511273.1_Missense_Mutation_p.P535T|CDH18_ENST00000502796.1_Missense_Mutation_p.P535T|CDH18_ENST00000274170.4_Missense_Mutation_p.P535T|CDH18_ENST00000382275.1_Missense_Mutation_p.P535T			Q13634	CAD18_HUMAN	cadherin 18, type 2	535	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTGAAGTTTGGATTTACAGGC	0.348000													20	63					2.4624e-09	3.15654e-09	1	1	0
TMEM169	92691	broad.mit.edu	37	2	216960740	216960740	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:216960740G>T	ENST00000454545.1	+	3	380	c.54G>T	c.(52-54)caG>caT	p.Q18H	TMEM169_ENST00000406027.2_Missense_Mutation_p.Q18H|TMEM169_ENST00000437356.2_Missense_Mutation_p.Q18H|TMEM169_ENST00000295658.4_Missense_Mutation_p.Q18H	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	18						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCCCCACCAGGGCTCTCTCA	0.542000													19	67					3.32936e-07	3.9405e-07	1	1	0
ITLN1	55600	broad.mit.edu	37	1	160851995	160851995	+	Splice_Site	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:160851995C>A	ENST00000326245.3	-	4	273		c.e4-1			NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)						positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding	p.?(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TACAGGCCATCTGTAGAGAGA	0.557000													43	77					1.35964e-18	2.17542e-18	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766829	77766829	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:77766829C>G	ENST00000521891.2	+	10	8120	c.7672C>G	c.(7672-7674)Caa>Gaa	p.Q2558E	ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q2513E|ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q2532E|ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q2513E	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2513						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCCCTCACTCAAATGCCCCC	0.507000										HNSCC(33;0.089)			25	91					0	0	1	0	0
LOC647323	647323	broad.mit.edu	37	3	193711948	193711948	+	RNA	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:193711948C>A	ENST00000397645.2	-	0	75				RP11-699L21.2_ENST00000426616.1_lincRNA	NR_033944.1																						ACACTTCCCTCATCAACTACT	0.413000													7	36					8.12818e-05	9.07332e-05	1	1	0
KIAA1586	57691	broad.mit.edu	37	6	56919043	56919043	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:56919043C>G	ENST00000370733.4	+	4	1953	c.1746C>G	c.(1744-1746)atC>atG	p.I582M	KIAA1586_ENST00000545356.1_Missense_Mutation_p.I555M	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	582							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAGATTTGATCAAGTCAGATA	0.269000													8	71					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102819820	102819820	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:102819820C>A	ENST00000260302.3	-	7	1013	c.985G>T	c.(985-987)Gaa>Taa	p.E329*	MMP13_ENST00000340273.4_Nonsense_Mutation_p.E329*	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	329	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTGGGAAGTTCTGGCCAAAAT	0.453000													26	91					9.39395e-14	1.34823e-13	1	1	0
OR2T34	127068	broad.mit.edu	37	1	248737693	248737693	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:248737693G>T	ENST00000328782.2	-	1	387	c.366C>A	c.(364-366)gcC>gcA	p.A122A		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATAGGCCATGGCAGCCAGGA	0.567000													17	83					1.22574e-08	1.51725e-08	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8471007	8471007	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:8471007C>T	ENST00000381196.4	-	28	4035	c.3492G>A	c.(3490-3492)atG>atA	p.M1164I	PTPRD_ENST00000397617.3_Missense_Mutation_p.M743I|PTPRD_ENST00000540109.1_Missense_Mutation_p.M1164I|PTPRD_ENST00000355233.5_Missense_Mutation_p.M753I|PTPRD_ENST00000358503.5_Missense_Mutation_p.M1142I|PTPRD_ENST00000360074.4_Missense_Mutation_p.M1151I|PTPRD_ENST00000537002.1_Missense_Mutation_p.M750I|PTPRD_ENST00000356435.5_Missense_Mutation_p.M1164I|PTPRD_ENST00000397611.3_Missense_Mutation_p.M750I|PTPRD_ENST00000397606.3_Missense_Mutation_p.M743I|PTPRD_ENST00000486161.1_Missense_Mutation_p.M753I	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1164					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CATCTAATTCCATTTCATCTG	0.413000										TSP Lung(15;0.13)			53	114					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99092233	99092233	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:99092233G>A	ENST00000376586.2	+	23	2881	c.2545G>A	c.(2545-2547)Gag>Aag	p.E849K	FARP1_ENST00000319562.6_Missense_Mutation_p.E818K|FARP1_ENST00000595437.1_Missense_Mutation_p.E849K			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	818	PH 1.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GAGCGAAGACGAGTGGGGGGT	0.622000													62	236					0	0	1	0	0
ALKBH2	121642	broad.mit.edu	37	12	109527870	109527870	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:109527870G>C	ENST00000429722.2	-	3	786	c.423C>G	c.(421-423)atC>atG	p.I141M	ALKBH2_ENST00000440112.2_Intron|ALKBH2_ENST00000343075.3_Missense_Mutation_p.I141M	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	141					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CGTGATCCCGGATGCGCTCTA	0.537000								Direct reversal of damage					12	87					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283123	69283123	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:69283123T>A	ENST00000338352.2	+	1	783	c.749T>A	c.(748-750)gTc>gAc	p.V250D		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	250	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						GAGGAGTACGTCAAGAAGCCG	0.662000													12	19					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93579	93579	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:93579C>A	ENST00000447903.2	-	4	852	c.537G>T	c.(535-537)cgG>cgT	p.R179R	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Silent_p.R251R|TUBB8_ENST00000332708.5_3'UTR			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	251					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CGGCCAGCTTCCGCAGGTCAG	0.637000													17	43					1.55795e-14	2.3208e-14	1	1	0
ZNF860	344787	broad.mit.edu	37	3	32030690	32030690	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:32030690G>T	ENST00000360311.4	+	2	668	c.119G>T	c.(118-120)tGc>tTc	p.C40F		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						GAGTGGAAATGCCTGGACCCT	0.478000													22	106					1.28384e-07	1.5449e-07	1	1	0
PHB	5245	broad.mit.edu	37	17	47482453	47482453	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:47482453C>G	ENST00000300408.3	-	7	792	c.720G>C	c.(718-720)aaG>aaC	p.K240N	PHB_ENST00000511832.1_Intron|RP11-1079K10.4_ENST00000506504.3_RNA|RP11-81K2.1_ENST00000576461.1_Intron	NM_002634.2	NP_002625.1	P35232	PHB_HUMAN	prohibitin	240					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding			endometrium(4)|large_intestine(2)|lung(4)	10	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			CAGCTTCCAGCTTGCGCAGCT	0.622000													6	17					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44502822	44502822	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:44502822G>A	ENST00000260649.6	+	1	224	c.148G>A	c.(148-150)Ggc>Agc	p.G50S	SLC3A1_ENST00000409229.3_Missense_Mutation_p.G50S|SLC3A1_ENST00000410056.3_Missense_Mutation_p.G50S|SLC3A1_ENST00000409741.1_Missense_Mutation_p.G50S|SLC3A1_ENST00000409387.1_Missense_Mutation_p.G50S	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	50					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CAGCACCAGGGGCATCCTTGG	0.597000													9	19					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214816525	214816525	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:214816525G>A	ENST00000366955.3	+	12	5012	c.4844G>A	c.(4843-4845)aGc>aAc	p.S1615N		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1711	2 X 96 AA approximate tandem repeats.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGCTGACAAGCGTGACTCTG	0.478000													51	39					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49508224	49508224	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:49508224A>C	ENST00000396029.3	-	5	3594	c.3027T>G	c.(3025-3027)agT>agG	p.S1009R	ADNP_ENST00000396032.3_Missense_Mutation_p.S1009R|ADNP_ENST00000349014.3_Missense_Mutation_p.S1009R|ADNP_ENST00000371602.4_Missense_Mutation_p.S1009R	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	1009						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						CAGCTGGCTTACTGCTCCTTG	0.463000													39	117					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1369194	1369194	+	Silent	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:1369194A>G	ENST00000446702.2	+	10	1764	c.1137A>G	c.(1135-1137)tcA>tcG	p.S379S	CNTN6_ENST00000350110.2_Silent_p.S379S|CNTN6_ENST00000539053.1_Silent_p.S307S			Q9UQ52	CNTN6_HUMAN	contactin 6	379	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGAATGTGTCAGATTCTGGTG	0.338000													19	63					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134019960	134019960	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:134019960C>G	ENST00000359428.5	+	12	1732	c.1588C>G	c.(1588-1590)Cta>Gta	p.L530V	RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000589667.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.L530V|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.L530V|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	530	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TAAAGCCTCCCTAGCCCCCAC	0.577000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								35	88					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39797772	39797772	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:39797772G>T	ENST00000564288.1	+	37	6289	c.5512G>T	c.(5512-5514)Gcc>Tcc	p.A1838S	MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.A1875S|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.A1843S|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.A278S			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1843					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGCTAAGATCGCCCTTGTGAT	0.488000													28	97					2.48779e-11	3.43363e-11	1	1	0
FSTL5	56884	broad.mit.edu	37	4	162697072	162697072	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:162697072A>C	ENST00000306100.5	-	5	1000	c.564T>G	c.(562-564)gaT>gaG	p.D188E	FSTL5_ENST00000427802.2_Missense_Mutation_p.D187E|FSTL5_ENST00000379164.4_Missense_Mutation_p.D187E|FSTL5_ENST00000536695.1_Missense_Mutation_p.D187E	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	188	EF-hand 1.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TACTGTCTGCATCAAAATATT	0.289000													37	96					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	102029383	102029383	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:102029383C>G	ENST00000251127.6	-	5	481	c.400G>C	c.(400-402)Gat>Cat	p.D134H	NALCN_ENST00000376200.5_Missense_Mutation_p.D134H|NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Missense_Mutation_p.D134H	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	134						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GACATCTGATCAACTATATCA	0.408000													14	64					0	0	1	0	0
ZNF718	255403	broad.mit.edu	37	4	154962	154962	+	RNA	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:154962A>T	ENST00000510175.1	+	0	397							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		CAAAGATAAGATAAGATATAC	0.289000													4	17					0	0	1	0	0
SPATA33	124045	broad.mit.edu	37	16	89724821	89724821	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:89724821C>T	ENST00000301031.4	+	2	200	c.200C>T	c.(199-201)tCg>tTg	p.S67L	SPATA33_ENST00000568929.1_Missense_Mutation_p.S37L|SPATA33_ENST00000579310.1_Missense_Mutation_p.S68L	NM_001271908.1|NM_153025.1	NP_001258837.1|NP_694570.1			spermatogenesis associated 33																		CCGGCAGCTTCGCTGGAAGGT	0.672000													5	13					0	0	1	0	0
PHF21A	51317	broad.mit.edu	37	11	45992772	45992772	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:45992772G>A	ENST00000257821.4	-	7	1130	c.507C>T	c.(505-507)ctC>ctT	p.L169L	PHF21A_ENST00000418153.2_Silent_p.L169L|PHF21A_ENST00000323180.6_Silent_p.L169L	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	169					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						CATCAGTGCTGAGCACAGCCT	0.542000													30	78					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490186	150490186	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:150490186T>A	ENST00000447204.2	-	5	962	c.590A>T	c.(589-591)cAg>cTg	p.Q197L	TMEM176B_ENST00000450753.2_Missense_Mutation_p.Q160L|TMEM176B_ENST00000326442.5_Missense_Mutation_p.Q197L|TMEM176B_ENST00000429904.2_Missense_Mutation_p.Q197L|TMEM176B_ENST00000434545.1_Missense_Mutation_p.Q197L|TMEM176B_ENST00000492607.1_Missense_Mutation_p.Q197L	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	197					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCAGCATCTGCATGTAAGC	0.557000													14	65					0	0	1	0	0
ANKRD55	79722	broad.mit.edu	37	5	55466583	55466583	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:55466583G>A	ENST00000341048.4	-	5	511	c.360C>T	c.(358-360)caC>caT	p.H120H	ANKRD55_ENST00000504958.2_Silent_p.H120H|ANKRD55_ENST00000513241.2_Silent_p.H91H	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	119										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				CTGGGATATTGTGCTTGGCAC	0.488000													35	95					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990462	63990462	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:63990462A>T	ENST00000370657.4	-	4	1027	c.994T>A	c.(994-996)Tct>Act	p.S332T	LGSN_ENST00000370658.5_Silent_p.L191L			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	332					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TCAGTTCCAGAAGTGCTGCAG	0.483000													22	48					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126154469	126154469	+	Missense_Mutation	SNP	C	C	A	rs148478516		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:126154469C>A	ENST00000393425.1	+	16	1798	c.1699C>A	c.(1699-1701)Cgc>Agc	p.R567S	CCDC37_ENST00000352312.1_Missense_Mutation_p.R566S|CCDC37_ENST00000506204.1_3'UTR|CCDC37_ENST00000505024.1_Missense_Mutation_p.R567S			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	566										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GGCCCGGGCGCGCGCCCAGGC	0.602000													4	25					0.00024832	0.000274359	1	1	0
LILRB4	11006	broad.mit.edu	37	19	55174999	55174999	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:55174999T>C	ENST00000391736.1	+	4	359	c.44T>C	c.(43-45)cTg>cCg	p.L15P	LILRB4_ENST00000391733.3_Missense_Mutation_p.L15P|LILRB4_ENST00000391734.3_Missense_Mutation_p.L15P|LILRB4_ENST00000270452.2_Missense_Mutation_p.L15P|LILRB4_ENST00000430952.2_Missense_Mutation_p.L15P	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	15						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GGGCTGAGTCTGGGCCCCAGG	0.562000													19	78					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461659	50461659	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:50461659C>G	ENST00000447370.2	-	8	1622	c.1532G>C	c.(1531-1533)gGg>gCg	p.G511A	SIGLEC11_ENST00000426971.2_Intron	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	511					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GGCCCAGGGCCCGGCTGAGCT	0.701000													10	24					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24805965	24805965	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:24805965G>A	ENST00000395799.3	+	8	3582	c.3453G>A	c.(3451-3453)atG>atA	p.M1151I	TNRC6A_ENST00000315183.7_Missense_Mutation_p.M1151I	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1151	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AGATTGGAATGTGGAATAGTA	0.438000													32	59					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18845911	18845911	+	RNA	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr22:18845911A>T	ENST00000412938.1	+	0	3269																											AAGAAAAGACACAGAGAAGGA	0.468000													3	20					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42680009	42680009	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:42680009G>T	ENST00000358131.5	+	4	710	c.502G>T	c.(502-504)Ggt>Tgt	p.G168C	TOX2_ENST00000341197.3_Missense_Mutation_p.G159C|TOX2_ENST00000435864.2_Missense_Mutation_p.G37C|TOX2_ENST00000372999.1_Missense_Mutation_p.G117C|TOX2_ENST00000423191.1_Missense_Mutation_p.G117C	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCCCTGCTGGGTCGCCCGGC	0.642000													12	29					1.49906e-05	1.69084e-05	1	1	0
ZNF211	10520	broad.mit.edu	37	19	58145430	58145430	+	Splice_Site	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:58145430G>C	ENST00000544273.1	+	3	453		c.e3+1		ZNF211_ENST00000240731.4_Splice_Site|ZNF211_ENST00000420680.1_Intron|ZNF211_ENST00000541801.1_Intron|ZNF211_ENST00000391703.3_Intron|ZNF211_ENST00000347302.3_Intron|ZNF211_ENST00000299871.5_Splice_Site|ZNF211_ENST00000254182.7_Splice_Site			Q13398	ZN211_HUMAN	zinc finger protein 211							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTTACACAGGTAAGTGGAGG	0.517000													9	50					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120983919	120983919	+	Splice_Site	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:120983919G>T	ENST00000392793.1	+	5	895		c.e5+1		TECTA_ENST00000264037.2_Splice_Site			O75443	TECTA_HUMAN	tectorin alpha						cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GATGGCACAGGTAGGTGGCTC	0.562000											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	65					2.89027e-11	3.95125e-11	1	1	0
PAQR6	79957	broad.mit.edu	37	1	156216474	156216474	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:156216474G>A	ENST00000292291.5	-	2	207	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	PAQR6_ENST00000335852.1_5'UTR|PAQR6_ENST00000368270.1_Intron|PAQR6_ENST00000540423.1_Intron|PAQR6_ENST00000492619.1_5'UTR|PAQR6_ENST00000360733.2_5'UTR|PAQR6_ENST00000356983.2_5'UTR	NM_001272104.1|NM_001272105.1|NM_198406.1	NP_001259033.1|NP_001259034.1|NP_940798.1	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	17						integral to membrane	receptor activity			lung(4)|ovary(1)	5	Hepatocellular(266;0.158)					CCCCTCACCCGGGGGACCTGG	0.592000													5	41					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50190888	50190888	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:50190888C>A	ENST00000335999.6	-	8	956	c.755G>T	c.(754-756)gGa>gTa	p.G252V		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	248	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CAGCAGGCCTCCCAGGTTGCC	0.716000													5	7					0.184627	0.185486	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70953089	70953089	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:70953089A>G	ENST00000551525.1	-	18	4769	c.4745T>C	c.(4744-4746)aTg>aCg	p.M1582T	PTPRB_ENST00000550358.1_Intron|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000550857.1_Intron|PTPRB_ENST00000334414.6_Intron|PTPRB_ENST00000261266.5_Intron			P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CCTCTACTCCATTTGAGAAAT	0.373000													52	122					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11795156	11795156	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:11795156G>A	ENST00000262442.3	+	58	11243	c.11175G>A	c.(11173-11175)gaG>gaA	p.E3725E	DNAH9_ENST00000396001.2_Silent_p.E37E|DNAH9_ENST00000454412.2_Silent_p.E3725E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3725					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCCTCAGGGAGCGGGTGGCCA	0.547000													52	152					0	0	1	0	0
LGALS16	148003	broad.mit.edu	37	19	40149298	40149298	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:40149298C>A	ENST00000392051.3	+	3	359	c.291C>A	c.(289-291)ctC>ctA	p.L97L		NM_001190441.1	NP_001177370.1	A8MUM7	A8MUM7_HUMAN	lectin, galactoside-binding, soluble, 16	97							sugar binding										ACGTGTGTCTCAATGAGTATG	0.517000													4	7					0.014758	0.0153996	1	1	0
ARAP2	116984	broad.mit.edu	37	4	36162126	36162126	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:36162126G>A	ENST00000303965.4	-	13	2886	c.2397C>T	c.(2395-2397)ttC>ttT	p.F799F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	799	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GAGTTTTTCTGAATTTTCCTT	0.303000													5	25					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31822048	31822048	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:31822048C>T	ENST00000343307.4	+	6	553	c.404C>T	c.(403-405)aCa>aTa	p.T135I		NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	135					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		GAAGAAGAGACAAGAATACAG	0.343000													14	52					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140799283	140799283	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140799283G>T	ENST00000398594.2	+	1	1857	c.1857G>T	c.(1855-1857)ctG>ctT	p.L619L	PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCAGCCTGGGGCTGCGAA	0.657000													30	81					2.68265e-12	3.7505e-12	1	1	0
MAPK8	5599	broad.mit.edu	37	10	49634457	49634457	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:49634457G>T	ENST00000374189.1	+	9	1087	c.906G>T	c.(904-906)ctG>ctT	p.L302L	MAPK8_ENST00000360332.3_Silent_p.L302L|MAPK8_ENST00000374182.3_Silent_p.L302L|MAPK8_ENST00000395611.3_Silent_p.L226L			P45983	MK08_HUMAN	mitogen-activated protein kinase 8	302	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding	p.L302L(2)		breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	34		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		CCAAAATGCTGGTAATAGATG	0.358000													36	70					7.04047e-22	1.1698e-21	1	1	0
G6PC2	57818	broad.mit.edu	37	2	169764540	169764540	+	Missense_Mutation	SNP	C	C	A	rs2232327		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:169764540C>A	ENST00000375363.3	+	5	1111	c.1019C>A	c.(1018-1020)cCc>cAc	p.P340H	G6PC2_ENST00000461586.1_3'UTR|SPC25_ENST00000472216.2_Intron	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	340			P -> L (in dbSNP:rs2232327).		gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity	p.P340H(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						GCTTTCATTCCCTACTCTGTT	0.428000													46	123					2.47872e-24	4.18285e-24	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60687819	60687819	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:60687819G>C	ENST00000335712.6	-	4	2455	c.2228C>G	c.(2227-2229)aCt>aGt	p.T743S	BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000537768.1_Missense_Mutation_p.T412S|BCL11A_ENST00000356842.4_Missense_Mutation_p.T743S|BCL11A_ENST00000538214.1_Missense_Mutation_p.T709S|BCL11A_ENST00000358510.4_Missense_Mutation_p.T709S	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	743					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GTACTCACAAGTGTCGCTGCG	0.587000			T	IGH@	B-CLL								42	95					0	0	1	0	0
C4orf26	152816	broad.mit.edu	37	4	76481261	76481261	+	Translation_Start_Site	SNP	A	A	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:76481261A>T	ENST00000311623.4	+	0	4				C4orf26_ENST00000514064.1_3'UTR	NM_001257072.1|NM_178497.3	NP_001244001.1|NP_848592.2	Q17RF5	CD026_HUMAN	chromosome 4 open reading frame 26							extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AAGCAACATCAGGTTCAACGC	0.522000													10	26					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18757499	18757499	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:18757499T>A	ENST00000304081.4	-	8	1380	c.1280A>T	c.(1279-1281)gAc>gTc	p.D427V	NT5C1B_ENST00000359846.2_Missense_Mutation_p.D487V|NT5C1B_ENST00000600945.1_Missense_Mutation_p.D487V|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.D487V	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAAGAATTTGTCGAGCCCATG	0.398000													26	37					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228528530	228528530	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:228528530G>T	ENST00000570156.2	+	83	20583	c.20509G>T	c.(20509-20511)Gtg>Ttg	p.V6837L	OBSCN_ENST00000366709.4_Missense_Mutation_p.V2999L|OBSCN_ENST00000284548.11_Missense_Mutation_p.V5880L|OBSCN_ENST00000366707.4_Missense_Mutation_p.V3514L|OBSCN_ENST00000422127.1_Missense_Mutation_p.V5880L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5880					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.V6462M(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAAGCTGCACGTGTCCCTCAT	0.672000													5	15					0.014758	0.0153996	1	1	0
CTNNAL1	8727	broad.mit.edu	37	9	111753118	111753118	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:111753118G>A	ENST00000374595.4	-	4	606	c.527C>T	c.(526-528)gCa>gTa	p.A176V	CTNNAL1_ENST00000325551.4_Missense_Mutation_p.A176V|CTNNAL1_ENST00000325580.6_Missense_Mutation_p.A176V			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	176					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		TTCCATAGTTGCGAGAACCTG	0.373000													13	40					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62287775	62287775	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:62287775T>A	ENST00000378024.4	-	5	14388	c.14114A>T	c.(14113-14115)aAg>aTg	p.K4705M	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4705					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTGGGGCCCTTTAGTTTCGC	0.488000													116	312					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74080606	74080606	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:74080606C>A	ENST00000607838.1	-	17	1931	c.1837G>T	c.(1837-1839)Gga>Tga	p.G613*	EXOC7_ENST00000589210.1_Nonsense_Mutation_p.G590*|EXOC7_ENST00000332065.5_Nonsense_Mutation_p.G559*|EXOC7_ENST00000411744.2_Nonsense_Mutation_p.G582*|EXOC7_ENST00000335146.7_Nonsense_Mutation_p.G641*|EXOC7_ENST00000405575.4_Nonsense_Mutation_p.G613*|EXOC7_ENST00000467929.2_Nonsense_Mutation_p.G562*	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	641					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			ACCTTGACTCCCGGCTGGAAC	0.547000													11	21					3.86212e-05	4.3336e-05	1	1	0
SPAG6	9576	broad.mit.edu	37	10	22680775	22680775	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:22680775G>T	ENST00000376603.2	+	8	1493	c.1351G>T	c.(1351-1353)Gca>Tca	p.A451S	SPAG6_ENST00000313311.6_Missense_Mutation_p.A375S|SPAG6_ENST00000490361.1_3'UTR|SPAG6_ENST00000538630.1_Missense_Mutation_p.A350S|SPAG6_ENST00000376601.1_Missense_Mutation_p.A136S|SPAG6_ENST00000376624.3_Missense_Mutation_p.A375S|RP11-301N24.3_ENST00000422675.1_RNA			O75602	SPAG6_HUMAN	sperm associated antigen 6	375					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						ACGGGCTGTTGCAGTCACAAA	0.433000													19	58					2.4624e-09	3.15654e-09	1	1	0
MYH8	4626	broad.mit.edu	37	17	10302105	10302105	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:10302105G>A	ENST00000403437.2	-	29	4055	c.3961C>T	c.(3961-3963)Caa>Taa	p.Q1321*	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1321					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCCTCTAGTTGATGTTTCAGC	0.388000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				25	84					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710463	140710463	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140710463G>T	ENST00000517417.1	+	1	212	c.212G>T	c.(211-213)aGg>aTg	p.R71M	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.R71M	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGAGGTAGGATGCCGCTT	0.597000													51	170					8.72198e-27	1.4952e-26	1	1	0
FEZF1	389549	broad.mit.edu	37	7	121942157	121942157	+	Missense_Mutation	SNP	G	G	T	rs144474907	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:121942157G>T	ENST00000442488.2	-	4	1389	c.1322C>A	c.(1321-1323)cCg>cAg	p.P441Q	FEZF1_ENST00000331178.4_Missense_Mutation_p.P437Q|FEZF1_ENST00000427185.2_Missense_Mutation_p.P391Q	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	441	Pro-rich.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						cgggggcggcggTTCAGTGCC	0.706000													13	49					6.72482e-11	9.10697e-11	1	1	0
DUOXA2	405753	broad.mit.edu	37	15	45408446	45408446	+	Silent	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:45408446T>C	ENST00000323030.5	+	3	615	c.330T>C	c.(328-330)atT>atC	p.I110I		NM_207581.3	NP_997464.2	Q1HG44	DOXA2_HUMAN	dual oxidase maturation factor 2	110					protein transport	endoplasmic reticulum membrane|integral to membrane							all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		GCATTAATATTACACTCACAG	0.577000													8	127					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	33038318	33038318	+	Splice_Site	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:33038318C>T	ENST00000357033.4	-	2	238		c.e2-1		DMD_ENST00000378677.2_Splice_Site|DMD_ENST00000288447.4_Splice_Site	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTCTTTCATCTAAAATGCAA	0.249000													9	4					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129618857	129618857	+	Silent	SNP	A	A	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:129618857A>C	ENST00000421865.2	+	21	2933	c.2884A>C	c.(2884-2886)Agg>Cgg	p.R962R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	962	Laminin EGF-like 9.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACAATCAGCAAGGGGCTGTGT	0.453000													31	29					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13240793	13240793	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:13240793G>T	ENST00000378694.1	+	15	2299	c.2224G>T	c.(2224-2226)Ggc>Tgc	p.G742C	MCM10_ENST00000484800.2_Missense_Mutation_p.G743C|MCM10_ENST00000378714.3_Missense_Mutation_p.G742C			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	743					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						AAAACACACAGGCATCCTGAA	0.438000													25	57					6.32553e-13	8.98891e-13	1	1	0
TFAP2D	83741	broad.mit.edu	37	6	50696618	50696618	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:50696618C>A	ENST00000008391.3	+	4	876	c.648C>A	c.(646-648)ggC>ggA	p.G216G	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	216							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CTGTCCCTGGCCGTTTGTCCC	0.473000													20	128					8.34094e-07	9.73861e-07	1	1	0
AGPAT9	84803	broad.mit.edu	37	4	84457912	84457912	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:84457912T>C	ENST00000395226.2	+	2	355	c.137T>C	c.(136-138)tTa>tCa	p.L46S	AGPAT9_ENST00000264409.4_Missense_Mutation_p.L46S	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	46					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				GTGAAAACTTTAGAGGTGAGT	0.582000													11	36					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62599251	62599251	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:62599251G>T	ENST00000512091.1	+	7	1921	c.1174G>T	c.(1174-1176)Gga>Tga	p.G392*	LPHN3_ENST00000507164.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000506720.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000514996.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000511324.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000506700.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000514157.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000504896.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000509896.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000508946.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000545650.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000507625.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000514591.1_Nonsense_Mutation_p.G392*|LPHN3_ENST00000506746.1_Nonsense_Mutation_p.G460*|LPHN3_ENST00000508693.1_Nonsense_Mutation_p.G460*			Q9HAR2	LPHN3_HUMAN	latrophilin 3	392	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TTTGGATTTTGGACCTCTGGA	0.358000													6	30					0.00116845	0.00126192	1	1	0
SLC26A3	1811	broad.mit.edu	37	7	107430026	107430026	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:107430026G>T	ENST00000340010.5	-	6	862	c.678C>A	c.(676-678)ctC>ctA	p.L226L	SLC26A3_ENST00000422236.2_Silent_p.L191L	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	226					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						AAATGAATTTGAGTTGGGAAA	0.388000													23	43					2.89027e-11	3.95125e-11	1	1	0
TGIF2	60436	broad.mit.edu	37	20	35207322	35207322	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:35207322C>G	ENST00000373874.2	+	2	344	c.145C>G	c.(145-147)Cag>Gag	p.Q49E	RP5-977B1.11_ENST00000561134.1_RNA|TGIF2-C20orf24_ENST00000558530.1_Missense_Mutation_p.Q49E|TGIF2_ENST00000373872.4_Missense_Mutation_p.Q49E	NM_001199514.1|NM_001199515.1	NP_001186443.1|NP_001186444.1	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	49						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(3)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CCCCTCAGAGCAGGAGAAGCT	0.597000													22	72					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26681821	26681821	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:26681821G>T	ENST00000256737.3	+	27	3628	c.2776G>T	c.(2776-2778)Ggg>Tgg	p.G926W	ANO3_ENST00000531568.1_Missense_Mutation_p.G780W|ANO3_ENST00000537978.1_Missense_Mutation_p.G910W|ANO3_ENST00000525139.1_Missense_Mutation_p.G910W	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	926						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						CCTTGTTTTTGGGATTAAGTC	0.353000													42	110					1.8453e-21	3.03106e-21	1	1	0
CLEC4G	339390	broad.mit.edu	37	19	7795936	7795936	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:7795936C>T	ENST00000328853.5	-	4	327	c.259G>A	c.(259-261)Gag>Aag	p.E87K	CLEC4G_ENST00000598081.1_5'UTR	NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	87						integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						TCTCCGACCTCCTCCTTCAGG	0.716000													9	21					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208842	58208842	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:58208842C>A	ENST00000377918.3	+	1	2188	c.2162C>A	c.(2161-2163)gCg>gAg	p.A721E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	721					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCCTCCTAGCGGCCATGATC	0.612000													22	81					0.000229342	0.000254693	1	1	0
CACNB1	782	broad.mit.edu	37	17	37343117	37343117	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:37343117G>A	ENST00000394303.3	-	5	687	c.480C>T	c.(478-480)ccC>ccT	p.P160P	CACNB1_ENST00000582877.1_5'UTR|CACNB1_ENST00000344140.5_Silent_p.P160P|CACNB1_ENST00000394310.3_Silent_p.P160P	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	160	SH3.				axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	TGACGGGGCTGGGAATGAAGC	0.587000													19	53					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678498	88678498	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:88678498C>A	ENST00000394480.1	-	10	1359	c.1038G>T	c.(1036-1038)aaG>aaT	p.K346N	NTRK3_ENST00000540489.2_Missense_Mutation_p.K346N|NTRK3_ENST00000360948.2_Missense_Mutation_p.K346N|NTRK3_ENST00000357724.2_Missense_Mutation_p.K346N|NTRK3_ENST00000558676.1_Missense_Mutation_p.K346N|NTRK3_ENST00000317501.3_Missense_Mutation_p.K346N|NTRK3_ENST00000542733.2_Missense_Mutation_p.K248N|NTRK3_ENST00000355254.2_Missense_Mutation_p.K346N|NTRK3_ENST00000557856.1_Missense_Mutation_p.K346N	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	346	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATGGATGATCTTGGACTCCC	0.567000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			37	89					3.66082e-28	6.37691e-28	1	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232601032	232601032	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:232601032G>T	ENST00000366630.1	-	8	2732	c.2374C>A	c.(2374-2376)Cat>Aat	p.H792N	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.H792N			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	792	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TCTGATTTATGGGCTGCATTT	0.483000													30	194					8.16721e-17	1.2646e-16	1	1	0
ITK	3702	broad.mit.edu	37	5	156638348	156638348	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:156638348C>A	ENST00000422843.3	+	3	446	c.294C>A	c.(292-294)agC>agA	p.S98R	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	98	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATCGTGAGAGCCGGCAGCGCT	0.488000			T	SYK	peripheral T-cell lymphoma								32	91					7.11191e-15	1.06679e-14	1	1	0
BMPR1A	657	broad.mit.edu	37	10	88677014	88677014	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:88677014G>T	ENST00000372037.2	+	9	1336	c.799G>T	c.(799-801)Gaa>Taa	p.E267*		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	267	Protein kinase.				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						CTTTACCACTGAAGAAGCCAG	0.448000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				17	48					1.9806e-07	2.37672e-07	1	1	0
ZNF518B	85460	broad.mit.edu	37	4	10446124	10446124	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:10446124T>A	ENST00000326756.3	-	3	2267	c.1829A>T	c.(1828-1830)cAg>cTg	p.Q610L		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ATCCCCAGGCTGTTGAGATCT	0.398000													71	168					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3022478	3022478	+	Splice_Site	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:3022478C>A	ENST00000397114.3	-	23	2459	c.2082_splice	c.e23-1	p.G695_splice	CARS_ENST00000278224.9_Splice_Site_p.M707_splice|CARS_ENST00000470221.2_5'UTR|CARS_ENST00000380525.4_Splice_Site_p.G788_splice|CARS_ENST00000401769.3_Splice_Site_p.M720_splice|CARS_ENST00000397111.5_Splice_Site_p.G705_splice			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	705					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	GTGGGCAGACCCTGAAAACCC	0.537000			T	ALK	ALCL								19	53					3.99206e-14	5.80663e-14	1	1	0
TRBV19	28568	broad.mit.edu	37	7	142326801	142326801	+	RNA	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:142326801G>T	ENST00000390393.3	+	0	307																											TGTTCAGAAAGGAAGGACAGA	0.517000													23	110					5.48756e-27	9.44473e-27	1	1	0
NFKBIA	4792	broad.mit.edu	37	14	35871600	35871600	+	Splice_Site	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:35871600C>T	ENST00000216797.5	-	5	1007	c.906_splice	c.e5+1	p.E302_splice	NFKBIA_ENST00000557140.1_Splice_Site_p.E259_splice|NFKBIA_ENST00000557389.1_Splice_Site_p.E212_splice	NM_020529.2	NP_065390.1	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	302					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(3)|endometrium(1)|large_intestine(2)|liver(1)	7	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		ACAGACTCACCTCGTCCTCTG	0.532000													34	88					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	171958099	171958099	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:171958099C>T	ENST00000358155.4	+	4	576	c.400C>T	c.(400-402)Ctt>Ttt	p.L134F	DNM3_ENST00000355305.5_Missense_Mutation_p.L134F|DNM3_ENST00000367733.2_Missense_Mutation_p.L134F|DNM3_ENST00000520906.1_Missense_Mutation_p.L134F|DNM3_ENST00000367731.1_Missense_Mutation_p.L134F	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	134					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AAATCTAACCCTTATTGATCT	0.393000													10	8					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539963	28539963	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:28539963C>A	ENST00000452236.2	-	4	4320	c.3703G>T	c.(3703-3705)Gga>Tga	p.G1235*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1235					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						attttcaatccttcgtcggta	0.333000													21	87					2.89027e-11	3.95125e-11	1	1	0
LILRA2	11027	broad.mit.edu	37	19	55086874	55086874	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:55086874G>T	ENST00000251377.3	+	6	940	c.807G>T	c.(805-807)tgG>tgT	p.W269C	LILRA2_ENST00000391737.1_Missense_Mutation_p.W257C|LILRA2_ENST00000391738.3_Missense_Mutation_p.W269C|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.W269C|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GCCCTGGTTGGCAGCCCCAGG	0.617000													30	79					3.03874e-20	4.91661e-20	1	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140750264	140750264	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140750264G>T	ENST00000576222.1	+	1	434	c.303G>T	c.(301-303)acG>acT	p.T101T	PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAGTCGACGTGTGTTCTGG	0.433000													91	260					1.38319e-45	2.56454e-45	1	1	0
LILRB4	11006	broad.mit.edu	37	19	55175000	55175000	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:55175000G>T	ENST00000391736.1	+	4	360	c.45G>T	c.(43-45)ctG>ctT	p.L15L	LILRB4_ENST00000391733.3_Silent_p.L15L|LILRB4_ENST00000391734.3_Silent_p.L15L|LILRB4_ENST00000270452.2_Silent_p.L15L|LILRB4_ENST00000430952.2_Silent_p.L15L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	15						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GGCTGAGTCTGGGCCCCAGGA	0.567000													20	78					1.5548e-18	2.4785e-18	1	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47121402	47121402	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:47121402G>T	ENST00000290341.3	+	11	1608	c.1274G>T	c.(1273-1275)gGg>gTg	p.G425V	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.G286V	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	425	KH 3.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GGCAAGAAGGGGCAGCACATC	0.587000													24	57					9.57634e-11	1.28878e-10	1	1	0
TNP2	7142	broad.mit.edu	37	16	11362812	11362812	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:11362812G>C	ENST00000312693.3	-	1	377	c.308C>G	c.(307-309)cCc>cGc	p.P103R	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	103					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						TCTGTTCTTGGGGCAGCGGCA	0.527000													11	55					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53603010	53603010	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:53603010C>A	ENST00000219022.2	+	1	117	c.39C>A	c.(37-39)ttC>ttA	p.F13L		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	13					cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CCCTTCTGTTCTTCCTTGGCC	0.587000													48	152					6.03219e-31	1.07682e-30	1	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576970	33576970	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:33576970G>C	ENST00000504830.1	-	19	3496	c.3161C>G	c.(3160-3162)aCc>aGc	p.T1054S	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.T969S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1054	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GGAGGCTGTGGTAGGACTAGG	0.562000										HNSCC(64;0.19)			21	74					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235878548	235878548	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:235878548A>G	ENST00000389794.3	-	42	9911	c.9737T>C	c.(9736-9738)tTc>tCc	p.F3246S	LYST_ENST00000389793.2_Missense_Mutation_p.F3246S|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3246	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CCTGACCAGGAAGTGAAGCAC	0.458000													28	164					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71050204	71050204	+	Silent	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:71050204G>C	ENST00000318789.4	-	13	1506	c.981C>G	c.(979-981)ctC>ctG	p.L327L	FOXP1_ENST00000491238.1_Silent_p.L329L|FOXP1_ENST00000493089.1_Silent_p.L327L|FOXP1_ENST00000498215.1_Silent_p.L327L|FOXP1_ENST00000484350.1_Silent_p.L251L|FOXP1_ENST00000475937.1_Silent_p.L327L|FOXP1_ENST00000468577.1_Silent_p.L327L	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	327					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GCTCACTGTTGAGATGTCTGC	0.383000			T	PAX5	ALL								22	70					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628085	71628085	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:71628085C>T	ENST00000377276.2	-	1	954	c.924G>A	c.(922-924)gaG>gaA	p.E308E		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	308	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCACCTTCTTCTCATAGATGG	0.552000													49	76					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620488	7620488	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:7620488T>C	ENST00000486284.1	+	8	2169	c.1895T>C	c.(1894-1896)cTt>cCt	p.L632P	GRM7_ENST00000403881.1_Missense_Mutation_p.L632P|GRM7_ENST00000357716.4_Missense_Mutation_p.L632P|GRM7_ENST00000389336.4_Missense_Mutation_p.L632P|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000402647.2_Missense_Mutation_p.L632P	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	632					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AGCTATGTTCTTTTGACGGGC	0.498000													73	146					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925149	218925149	+	RNA	SNP	G	G	A	rs6758271	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:218925149G>A	ENST00000439871.1	-	0	1231					NR_002712.1																						TGATCAAGCCGTGTATGGCTA	0.502000													5	75					0	0	1	0	0
GCNT4	51301	broad.mit.edu	37	5	74324737	74324737	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:74324737C>A	ENST00000322348.4	-	1	1987	c.1126G>T	c.(1126-1128)Ggc>Tgc	p.G376C		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	376					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TAGAAAAAGCCTTCATAGTAA	0.458000													19	60					1.67942e-08	2.07288e-08	1	1	0
DLGAP2	9228	broad.mit.edu	37	8	1575027	1575027	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:1575027C>A	ENST00000421627.2	+	4	1458	c.1324C>A	c.(1324-1326)Ctg>Atg	p.L442M		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	521					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CGTCAGCACCCTGAGCCAGGC	0.667000													4	7					0.150653	0.152775	1	1	0
HPX	3263	broad.mit.edu	37	11	6453180	6453180	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:6453180C>A	ENST00000265983.3	-	8	1003	c.903G>T	c.(901-903)tgG>tgT	p.W301C		NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	301	Hemopexin-like 4.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GACCCTGGGGCCACTGATGAG	0.577000													56	127					3.07002e-29	5.39125e-29	1	1	0
CACNA1C	775	broad.mit.edu	37	12	2711026	2711026	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:2711026G>T	ENST00000399655.1	+	22	3125	c.2860G>T	c.(2860-2862)Gct>Tct	p.A954S	CACNA1C_ENST00000399629.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399617.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399641.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000406454.3_Missense_Mutation_p.A954S|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A954S|CACNA1C_ENST00000399621.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A954S|CACNA1C_ENST00000399637.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399634.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000347598.4_Missense_Mutation_p.A974S|CACNA1C_ENST00000399644.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A974S|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A954S|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399603.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A954S|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A979S|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A954S	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	974					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCAGATGACTGCTTATGGGGC	0.572000													14	33					3.27435e-08	3.99582e-08	1	1	0
CLEC1A	51267	broad.mit.edu	37	12	10233909	10233909	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:10233909C>A	ENST00000315330.4	-	3	380	c.318G>T	c.(316-318)caG>caT	p.Q106H	CLEC1A_ENST00000457018.2_Missense_Mutation_p.Q73H|CLEC1A_ENST00000420265.2_Intron	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	106					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						GCTTTATATTCTGGACTTGAA	0.443000													38	107					4.32679e-17	6.72365e-17	1	1	0
TNFSF15	9966	broad.mit.edu	37	9	117568147	117568147	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr9:117568147C>A	ENST00000374045.4	-	1	259	c.146G>T	c.(145-147)gGa>gTa	p.G49V		NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	49					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						TGTGGTGAGTCCTGCAAGGAA	0.637000													21	40					1.87028e-06	2.17194e-06	1	1	0
BDP1	55814	broad.mit.edu	37	5	70858315	70858315	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:70858315C>T	ENST00000358731.4	+	38	7974	c.7711C>T	c.(7711-7713)Caa>Taa	p.Q2571*	BDP1_ENST00000380675.2_3'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2571					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TATTACTACTCAATCTGAGAA	0.348000													41	113					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662869	662869	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:662869G>T	ENST00000266383.5	+	14	1793	c.1780G>T	c.(1780-1782)Gtg>Ttg	p.V594L		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	594						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGAGGAAGTGGTGGCGGCCGC	0.617000													18	42					3.32936e-07	3.9405e-07	1	1	0
CALN1	83698	broad.mit.edu	37	7	71488746	71488746	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:71488746G>C	ENST00000395275.2	-	5	785	c.397C>G	c.(397-399)Cag>Gag	p.Q133E	CALN1_ENST00000412588.1_Missense_Mutation_p.Q133E|CALN1_ENST00000395276.2_Missense_Mutation_p.Q91E|CALN1_ENST00000329008.5_Missense_Mutation_p.Q91E|CALN1_ENST00000431984.1_Missense_Mutation_p.Q91E|CALN1_ENST00000405452.2_Missense_Mutation_p.Q91E	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	91						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AAATCCACCTGGCCATCCCCT	0.448000													30	61					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75960891	75960891	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:75960891G>T	ENST00000274364.6	+	22	2867	c.2570G>T	c.(2569-2571)gGa>gTa	p.G857V	IQGAP2_ENST00000379730.3_Missense_Mutation_p.G359V|IQGAP2_ENST00000502745.1_Missense_Mutation_p.G353V|IQGAP2_ENST00000396234.3_Missense_Mutation_p.G353V	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	857					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AAGAAAAAAGGAGGAGAAATG	0.328000													11	63					0.000978159	0.00106708	1	1	0
ZC3H13	23091	broad.mit.edu	37	13	46542005	46542005	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:46542005T>C	ENST00000242848.4	-	15	4303	c.3955A>G	c.(3955-3957)Agg>Ggg	p.R1319G	ZC3H13_ENST00000378921.2_Missense_Mutation_p.R275G|ZC3H13_ENST00000282007.3_Missense_Mutation_p.R1319G			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1319							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		tctctctgcctcgtatctctc	0.493000													32	64					0	0	1	0	0
BTG4	54766	broad.mit.edu	37	11	111365897	111365897	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:111365897C>A	ENST00000356018.2	-	5	852	c.653G>T	c.(652-654)cGg>cTg	p.R218L		NM_017589.3	NP_060059.1	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	218					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		CCTGTCCAGCCGGTGCATAGC	0.552000													26	55					7.26314e-15	1.0857e-14	1	1	0
POF1B	79983	broad.mit.edu	37	X	84569447	84569447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:84569447G>T	ENST00000262753.4	-	9	1093	c.948C>A	c.(946-948)taC>taA	p.Y316*	POF1B_ENST00000373145.3_Nonsense_Mutation_p.Y316*	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	316							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						CCTGCAGAATGTAGCGTATTT	0.383000													16	11					2.31682e-05	2.60643e-05	1	1	0
MAP1A	4130	broad.mit.edu	37	15	43818748	43818748	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:43818748C>A	ENST00000382031.1	+	5	5822	c.5791C>A	c.(5791-5793)Cag>Aag	p.Q1931K	MAP1A_ENST00000300231.5_Missense_Mutation_p.Q1693K|MAP1A_ENST00000399453.1_Missense_Mutation_p.Q1693K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1693						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGCCTTGGAACAGGACACATA	0.602000													9	22					4.68919e-08	5.70628e-08	1	1	0
ITPR3	3710	broad.mit.edu	37	6	33638117	33638117	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:33638117C>T	ENST00000374316.5	+	20	3265	c.2205C>T	c.(2203-2205)ctC>ctT	p.L735L	ITPR3_ENST00000605930.1_Silent_p.L735L			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	735					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						AGCTGAAGCTCTTTGCCCGCA	0.607000													42	80					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1575026	1575026	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:1575026C>A	ENST00000421627.2	+	4	1457	c.1323C>A	c.(1321-1323)acC>acA	p.T441T		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	520					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCGTCAGCACCCTGAGCCAGG	0.672000													4	7					0.150653	0.152775	1	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140724491	140724491	+	Silent	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140724491G>C	ENST00000253812.6	+	1	891	c.891G>C	c.(889-891)gtG>gtC	p.V297V	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAACTCAGTGAGTGGAGAAG	0.383000													13	44					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78569162	78569162	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:78569162C>A	ENST00000397909.2	+	25	5231	c.5058C>A	c.(5056-5058)ggC>ggA	p.G1686G	NAV3_ENST00000228327.6_Silent_p.G1686G|NAV3_ENST00000266692.7_Silent_p.G1509G|NAV3_ENST00000536525.2_Silent_p.G1686G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1686						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCAGTATTGGCAGTGGTAATG	0.403000										HNSCC(70;0.22)			25	83					2.21704e-12	3.10961e-12	1	1	0
ITGA8	8516	broad.mit.edu	37	10	15617546	15617546	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:15617546G>T	ENST00000378076.3	-	24	2773	c.2420C>A	c.(2419-2421)cCa>cAa	p.P807Q		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	807					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTCCTCTTCTGGTTCCCAGTT	0.443000													27	68					1.55811e-20	2.53046e-20	1	1	0
MMP11	4320	broad.mit.edu	37	22	24122662	24122662	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr22:24122662G>T	ENST00000215743.3	+	3	507	c.455G>T	c.(454-456)cGt>cTt	p.R152L	MMP11_ENST00000477567.1_3'UTR	NM_005940.3	NP_005931.2	P24347	MMP11_HUMAN	matrix metallopeptidase 11 (stromelysin 3)	152					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CACGAGGGCCGTGCTGACATC	0.642000													17	55					1.56452e-12	2.20874e-12	1	1	0
NID2	22795	broad.mit.edu	37	14	52520632	52520632	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:52520632G>T	ENST00000216286.5	-	5	1093	c.1094C>A	c.(1093-1095)aCc>aAc	p.T365N	NID2_ENST00000541773.1_Missense_Mutation_p.T312N	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	365						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TCCTTCTTTGGTGTGAGGATC	0.517000													27	68					7.41945e-09	9.2369e-09	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													13	300					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9792733	9792733	+	Missense_Mutation	SNP	G	G	A	rs143908746	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:9792733G>A	ENST00000262441.5	+	13	1886	c.1373G>A	c.(1372-1374)cGc>cAc	p.R458H	GLP2R_ENST00000574745.1_Missense_Mutation_p.R278H	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	458					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	TTGCTAGCCCGCCACTCAGGC	0.562000													17	39					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100002653	100002653	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:100002653C>A	ENST00000398027.2	-	13	1481	c.1234G>T	c.(1234-1236)Gaa>Taa	p.E412*	ZCWPW1_ENST00000324725.6_Nonsense_Mutation_p.E292*|ZCWPW1_ENST00000360951.4_Nonsense_Mutation_p.E413*|ZCWPW1_ENST00000490721.1_Nonsense_Mutation_p.E292*	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	412							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGATCTGTTCTGCCTCTTGA	0.473000													68	183					9.13743e-30	1.62443e-29	1	1	0
CLN5	1203	broad.mit.edu	37	13	77566284	77566284	+	Silent	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:77566284G>T	ENST00000377453.3	+	1	1490	c.198G>T	c.(196-198)gcG>gcT	p.A66A	CLN5_ENST00000485938.1_3'UTR	NM_006493.2	NP_006484.1	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	17					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		ggcggggcgcgggcgcggcTC	0.746000													5	16					0.0215528	0.022328	1	1	0
SLFN12L	100506736	broad.mit.edu	37	17	33849821	33849821	+	Translation_Start_Site	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:33849821C>A	ENST00000361112.4	-	0	456							Q6IEE8	SN12L_HUMAN	schlafen family member 12-like							integral to membrane	ATP binding			breast(1)|endometrium(4)|kidney(5)|large_intestine(2)|lung(3)|ovary(1)	16						CAGATGACTCCTGGCTTCTCC	0.488000													12	30					2.27111e-07	2.71778e-07	1	1	0
LPHN3	23284	broad.mit.edu	37	4	62599252	62599252	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:62599252G>T	ENST00000512091.1	+	7	1922	c.1175G>T	c.(1174-1176)gGa>gTa	p.G392V	LPHN3_ENST00000507164.1_Missense_Mutation_p.G460V|LPHN3_ENST00000506720.1_Missense_Mutation_p.G460V|LPHN3_ENST00000514996.1_Missense_Mutation_p.G392V|LPHN3_ENST00000511324.1_Missense_Mutation_p.G460V|LPHN3_ENST00000506700.1_Missense_Mutation_p.G392V|LPHN3_ENST00000514157.1_Missense_Mutation_p.G392V|LPHN3_ENST00000504896.1_Missense_Mutation_p.G392V|LPHN3_ENST00000509896.1_Missense_Mutation_p.G460V|LPHN3_ENST00000508946.1_Missense_Mutation_p.G392V|LPHN3_ENST00000545650.1_Missense_Mutation_p.G392V|LPHN3_ENST00000507625.1_Missense_Mutation_p.G460V|LPHN3_ENST00000514591.1_Missense_Mutation_p.G392V|LPHN3_ENST00000506746.1_Missense_Mutation_p.G460V|LPHN3_ENST00000508693.1_Missense_Mutation_p.G460V			Q9HAR2	LPHN3_HUMAN	latrophilin 3	392	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.G392V(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TTGGATTTTGGACCTCTGGAT	0.358000													6	29					0.00116845	0.00126192	1	1	0
B3GNT1	11041	broad.mit.edu	37	11	66114913	66114913	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:66114913C>A	ENST00000311181.4	-	1	250	c.104G>T	c.(103-105)gGa>gTa	p.G35V		NM_006876.2	NP_006867.1	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	35					poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	12						CCCGTGCAGTCCGGACAGCAG	0.647000													8	7					1.58986e-06	1.85127e-06	1	1	0
FUZ	80199	broad.mit.edu	37	19	50310428	50310428	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:50310428C>T	ENST00000313777.4	-	11	1400	c.1237G>A	c.(1237-1239)Gcc>Acc	p.A413T	FUZ_ENST00000528094.1_Missense_Mutation_p.A377T|FUZ_ENST00000445575.2_Intron|FUZ_ENST00000533418.1_Missense_Mutation_p.A363T	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	413	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GGGGTGAGGGCATGCAGAGTG	0.592000													11	38					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74080607	74080607	+	Silent	SNP	C	C	A	rs148929452		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:74080607C>A	ENST00000607838.1	-	17	1930	c.1836G>T	c.(1834-1836)ccG>ccT	p.P612P	EXOC7_ENST00000589210.1_Silent_p.P589P|EXOC7_ENST00000332065.5_Silent_p.P558P|EXOC7_ENST00000411744.2_Silent_p.P581P|EXOC7_ENST00000335146.7_Silent_p.P640P|EXOC7_ENST00000405575.4_Silent_p.P612P|EXOC7_ENST00000467929.2_Silent_p.P561P	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	640					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			CCTTGACTCCCGGCTGGAACA	0.547000													10	22					0.000442599	0.000486521	1	1	0
CHRNA4	1137	broad.mit.edu	37	20	61990927	61990927	+	Silent	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr20:61990927G>C	ENST00000370263.4	-	2	422	c.201C>G	c.(199-201)ggC>ggG	p.G67G	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	67					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGATGGACAGGCCGAAGCGGA	0.632000													11	45					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3200874	3200874	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:3200874C>G	ENST00000602557.1	-	24	4131	c.3576G>C	c.(3574-3576)tgG>tgC	p.W1192C	CSMD1_ENST00000542608.1_Missense_Mutation_p.W1191C|CSMD1_ENST00000537824.1_Missense_Mutation_p.W1191C|CSMD1_ENST00000400186.3_Missense_Mutation_p.W1192C|CSMD1_ENST00000520002.1_Missense_Mutation_p.W1192C|CSMD1_ENST00000539096.1_Missense_Mutation_p.W1191C|CSMD1_ENST00000602723.1_Missense_Mutation_p.W1192C			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1192	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAACTCTAGCCACAGGTGAT	0.423000													39	65					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7092437	7092437	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:7092437G>T	ENST00000299481.4	+	12	3526	c.3180G>T	c.(3178-3180)caG>caT	p.Q1060H		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	1060					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGGAAGCCCAGAAGCTGCTGG	0.433000													25	47					2.98393e-07	3.56093e-07	1	1	0
CNKSR2	22866	broad.mit.edu	37	X	21624983	21624983	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:21624983C>A	ENST00000425654.2	+	18	2521	c.2041C>A	c.(2041-2043)Cca>Aca	p.P681T	CNKSR2_ENST00000379510.3_Missense_Mutation_p.P711T|CNKSR2_ENST00000279451.4_Missense_Mutation_p.P711T|CNKSR2_ENST00000543067.1_Missense_Mutation_p.P662T	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	711					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TGATACATACCCACGACCTCC	0.398000													27	22					4.74835e-14	6.88352e-14	1	1	0
ERICH1	157697	broad.mit.edu	37	8	642556	642556	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:642556C>T	ENST00000262109.7	-	3	303	c.226G>A	c.(226-228)Gag>Aag	p.E76K	ERICH1_ENST00000522706.1_Intron|ERICH1_ENST00000518277.1_5'UTR	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	76										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		ACGTAGCCCTCAGGAGGCCCG	0.597000													14	81					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10439614	10439614	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:10439614G>C	ENST00000293677.6	-	3	592	c.511C>G	c.(511-513)Ccc>Gcc	p.P171A		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	154	RRM 2.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CTGCCGAAGGGCCGCACCAGC	0.632000													5	6					0	0	1	0	0
C19orf44	84167	broad.mit.edu	37	19	16611970	16611970	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:16611970G>T	ENST00000221671.3	+	2	523	c.367G>T	c.(367-369)Gcc>Tcc	p.A123S	CTD-3222D19.2_ENST00000409035.1_Intron|C19orf44_ENST00000594035.1_Missense_Mutation_p.A123S	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	123										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						CTCAATGACCGCCGATGCTGG	0.542000													33	68					2.1956e-27	3.80923e-27	1	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885415	88885415	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:88885415C>T	ENST00000319675.3	-	1	881	c.785G>A	c.(784-786)tGg>tAg	p.W262*		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	262										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AATGGCCTTCCACCCGCTGCC	0.502000													63	80					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156646841	156646841	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:156646841C>T	ENST00000368223.3	-	1	348	c.216G>A	c.(214-216)cgG>cgA	p.R72R		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	72	Coil 1B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGTGCTTCTCCCGCCAGCGTT	0.741000													4	16					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10211558	10211558	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:10211558G>A	ENST00000377157.3	+	20	3191	c.2130G>A	c.(2128-2130)atG>atA	p.M710I	UBE4B_ENST00000343090.6_Missense_Mutation_p.M955I|UBE4B_ENST00000253251.8_Missense_Mutation_p.M826I	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	955					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TTTTTGAAATGATTGAGAACC	0.453000													39	123					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167228	140167228	+	Silent	SNP	C	C	T	rs143660641		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:140167228C>T	ENST00000504120.2	+	1	1353	c.1353C>T	c.(1351-1353)aaC>aaT	p.N451N	PCDHA1_ENST00000378133.3_Silent_p.N451N|PCDHA1_ENST00000394633.3_Silent_p.N451N	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATGACAACGCGCCTGCGT	0.677000													44	80					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41559874	41559874	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr21:41559874C>A	ENST00000400454.1	-	13	3071	c.2594G>T	c.(2593-2595)tGc>tTc	p.C865F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	865	Ig-like C2-type 9.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AATAGCATGGCAGGAAAAGAA	0.398000													22	61					1.50039e-11	2.07746e-11	1	1	0
SLC6A9	6536	broad.mit.edu	37	1	44467199	44467199	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:44467199C>A	ENST00000372310.3	-	9	1228	c.1063G>T	c.(1063-1065)Gat>Tat	p.D355Y	SLC6A9_ENST00000360584.2_Missense_Mutation_p.D428Y|SLC6A9_ENST00000357730.2_Missense_Mutation_p.D374Y|SLC6A9_ENST00000475075.2_Missense_Mutation_p.D244Y|SLC6A9_ENST00000372307.3_Missense_Mutation_p.D290Y|SLC6A9_ENST00000372306.3_Missense_Mutation_p.D355Y|SLC6A9_ENST00000537678.1_Missense_Mutation_p.D290Y	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	428						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CGGGACACATCCACGCCCAGG	0.602000													47	102					1.41504e-22	2.36936e-22	1	1	0
NLRP3	114548	broad.mit.edu	37	1	247588028	247588028	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:247588028G>C	ENST00000366497.2	+	4	2063	c.1283G>C	c.(1282-1284)aGt>aCt	p.S428T	NLRP3_ENST00000391827.2_Missense_Mutation_p.S428T|NLRP3_ENST00000366496.2_Missense_Mutation_p.S428T|NLRP3_ENST00000348069.2_Missense_Mutation_p.S428T|NLRP3_ENST00000336119.3_Missense_Mutation_p.S428T|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Missense_Mutation_p.S428T	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	428	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGATGGAGAGTGGCAAGAGC	0.587000													16	125					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586584	20586584	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:20586584G>T	ENST00000315543.4	+	1	1019	c.1019G>T	c.(1018-1020)aGa>aTa	p.R340I		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTGAATTCTAGAGAAGATACT	0.408000													8	35					0.0477658	0.0488976	1	1	0
PUSL1	126789	broad.mit.edu	37	1	1246437	1246437	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:1246437T>C	ENST00000379031.5	+	7	925	c.848T>C	c.(847-849)cTg>cCg	p.L283P		NM_153339.1	NP_699170.1	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	283					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			lung(3)|skin(1)|urinary_tract(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AAGTCAGTGCTGTACGGGAAC	0.607000													19	65					0	0	1	0	0
TRAM1	23471	broad.mit.edu	37	8	71508556	71508556	+	Splice_Site	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:71508556C>A	ENST00000521425.1	-	5	1205	c.168_splice	c.e5-1	p.E57_splice	TRAM1_ENST00000262213.2_Splice_Site_p.E143_splice|TRAM1_ENST00000536748.1_Splice_Site_p.E112_splice|TRAM1_ENST00000521049.1_Intron			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	143					cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			ATGTAGTTTTCCTAAGAAAGA	0.373000													65	91					1.1362e-29	2.01163e-29	1	1	0
COPG1	22820	broad.mit.edu	37	3	128976378	128976378	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr3:128976378C>G	ENST00000314797.6	+	9	749	c.645C>G	c.(643-645)atC>atG	p.I215M		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	215					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										ATAAGATGATCAGCAAGGTCA	0.532000													63	170					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196834683	196834683	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:196834683C>G	ENST00000312428.6	-	17	2294	c.2194G>C	c.(2194-2196)Gct>Cct	p.A732P		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	732	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTATCTGCAGCTAAATCCAAC	0.299000													19	62					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100192084	100192084	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:100192084C>A	ENST00000231461.5	-	4	830	c.520G>T	c.(520-522)Gtg>Ttg	p.V174L		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	174					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		AACTCCACCACAGGAGCTAGA	0.363000													17	53					2.94398e-08	3.60283e-08	1	1	0
TCL1A	8115	broad.mit.edu	37	14	96178585	96178585	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr14:96178585C>A	ENST00000402399.1	-	2	398	c.269G>T	c.(268-270)aGt>aTt	p.S90I	TCL1A_ENST00000555202.1_Missense_Mutation_p.S90I|TCL1A_ENST00000554012.1_Missense_Mutation_p.S90I|RP11-164H13.1_ENST00000547644.2_RNA|TCL1A_ENST00000556450.1_Missense_Mutation_p.S90I|RP11-164H13.1_ENST00000553445.1_RNA	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	90					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GCGCCAGAAACTGGAGTCTGA	0.567000			T	TRA@	T-CLL								48	163					6.03219e-31	1.07682e-30	1	1	0
EVC2	132884	broad.mit.edu	37	4	5630425	5630425	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:5630425T>A	ENST00000310917.2	-	12	2238	c.1507A>T	c.(1507-1509)Agt>Tgt	p.S503C	EVC2_ENST00000344408.5_Missense_Mutation_p.S583C|EVC2_ENST00000344938.1_Missense_Mutation_p.S583C	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	583						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TACCTCTTACTAGCCTGGAAA	0.393000													28	75					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36162149	36162149	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:36162149G>A	ENST00000303965.4	-	13	2863	c.2374C>T	c.(2374-2376)Cag>Tag	p.Q792*		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	792	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTATATTTCTGAGTAATAAAG	0.318000													7	25					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398282	25398282	+	Missense_Mutation	SNP	C	C	A	rs121913535		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:25398282C>A	ENST00000311936.3	-	2	228	c.37G>T	c.(37-39)Ggc>Tgc	p.G13C	KRAS_ENST00000556131.1_Missense_Mutation_p.G13C|KRAS_ENST00000557334.1_Missense_Mutation_p.G13C|KRAS_ENST00000256078.4_Missense_Mutation_p.G13C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	13			G -> D (in a breast carcinoma cell line and GASC; somatic mutation).|G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TTGCCTACGCCACCAGCTCCA	0.343000	G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	31					0.00448238	0.00478121	1	1	0
LCMT2	9836	broad.mit.edu	37	15	43621286	43621286	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:43621286T>A	ENST00000305641.5	-	1	1517	c.1402A>T	c.(1402-1404)Aag>Tag	p.K468*	LCMT2_ENST00000567039.1_3'UTR|LCMT2_ENST00000544735.1_Nonsense_Mutation_p.K47*	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	468					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CGGCCAGCCTTTGTTATTGTC	0.458000													35	87					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19503169	19503169	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr5:19503169G>C	ENST00000507958.1	-	13	2552	c.1562C>G	c.(1561-1563)cCa>cGa	p.P521R	CDH18_ENST00000506372.1_Missense_Mutation_p.P521R|CDH18_ENST00000511273.1_Missense_Mutation_p.P521R|CDH18_ENST00000502796.1_Missense_Mutation_p.P521R|CDH18_ENST00000274170.4_Missense_Mutation_p.P521R|CDH18_ENST00000382275.1_Missense_Mutation_p.P521R			Q13634	CAD18_HUMAN	cadherin 18, type 2	521	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTTAAACCTTGGTCCATTGGC	0.333000													11	70					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103202357	103202357	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:103202357C>A	ENST00000424685.2	-	35	5413	c.5254G>T	c.(5254-5256)Gtg>Ttg	p.V1752L	RELN_ENST00000343529.5_Missense_Mutation_p.V1752L|RELN_ENST00000428762.1_Missense_Mutation_p.V1752L			P78509	RELN_HUMAN	reelin	1752					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCAGCCCCCACAGTGTAGTTG	0.483000													14	44					0.000422831	0.000465978	1	1	0
ZNF676	163223	broad.mit.edu	37	19	22363771	22363771	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:22363771C>T	ENST00000397121.2	-	3	1065	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TAGGGTTTCTCTCCAGTATGA	0.378000													29	141					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897454	153897454	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:153897454G>T	ENST00000511601.1	+	12	3199	c.3011G>T	c.(3010-3012)cGc>cTc	p.R1004L	FHDC1_ENST00000260008.3_Missense_Mutation_p.R1004L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1004					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					AAGACCTGCCGCGCCCACTCC	0.627000													20	54					1.15919e-05	1.31091e-05	1	1	0
BMPR1B	658	broad.mit.edu	37	4	96046198	96046198	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:96046198C>A	ENST00000515059.1	+	8	794	c.511C>A	c.(511-513)Cct>Act	p.P171T	BMPR1B_ENST00000440890.2_Missense_Mutation_p.P201T|BMPR1B_ENST00000264568.4_Missense_Mutation_p.P171T|BMPR1B_ENST00000394931.1_Missense_Mutation_p.P171T	NM_001203.2	NP_001194.1	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	171					BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		AACTTACATTCCTCCTGGAGA	0.408000													15	55					2.32078e-09	3.00173e-09	1	1	0
ITGA10	8515	broad.mit.edu	37	1	145535896	145535896	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:145535896A>G	ENST00000369304.3	+	16	2259	c.2084A>G	c.(2083-2085)cAa>cGa	p.Q695R	ITGA10_ENST00000539363.1_Missense_Mutation_p.Q552R|ITGA10_ENST00000538811.1_Missense_Mutation_p.Q564R	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	695					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGGATCACCAATTCTGTGAG	0.532000													35	167					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23931765	23931765	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr15:23931765C>T	ENST00000331837.4	-	1	685	c.600G>A	c.(598-600)gtG>gtA	p.V200V		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	200	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGCGGCCCTTCACGTAGATGA	0.662000									Prader-Willi syndrome				12	27					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57012130	57012130	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:57012130C>A	ENST00000200676.3	+	11	1239	c.1109C>A	c.(1108-1110)cCa>cAa	p.P370Q	CETP_ENST00000566128.1_Missense_Mutation_p.P305Q|CETP_ENST00000379780.2_Missense_Mutation_p.P310Q	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	370					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						TTTCCACGCCCAGACCAGCAA	0.542000													40	128					3.54909e-21	5.78569e-21	1	1	0
ARHGAP9	64333	broad.mit.edu	37	12	57869697	57869697	+	Silent	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:57869697G>A	ENST00000393797.2	-	13	1635	c.1443C>T	c.(1441-1443)ggC>ggT	p.G481G	ARHGAP9_ENST00000356411.2_Silent_p.G410G|ARHGAP9_ENST00000393791.3_Silent_p.G410G|ARHGAP9_ENST00000424809.2_Silent_p.G410G|ARHGAP9_ENST00000550288.1_Silent_p.G489G|ARHGAP9_ENST00000430041.2_Silent_p.G226G			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	410					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGAACTCGTGGCCAGGGATCG	0.652000													6	19					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94040217	94040217	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:94040217G>T	ENST00000297268.6	+	22	1685	c.1214G>T	c.(1213-1215)cGt>cTt	p.R405L		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	405					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCTGGTTCTCGTGGTCTTCCT	0.443000										HNSCC(75;0.22)			23	82					7.41877e-09	9.2369e-09	1	1	0
HADHB	3032	broad.mit.edu	37	2	26486259	26486259	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:26486259A>G	ENST00000317799.5	+	4	225	c.121A>G	c.(121-123)Aaa>Gaa	p.K41E	HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000545822.1_Missense_Mutation_p.K19E|HADHB_ENST00000405867.3_Missense_Mutation_p.K41E|HADHB_ENST00000537713.1_Missense_Mutation_p.K41E	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	41					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCCAGACCAAAACGAAGAA	0.328000													44	106					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53825063	53825063	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:53825063C>A	ENST00000257863.4	+	11	1608	c.1528C>A	c.(1528-1530)Cat>Aat	p.H510N	AMHR2_ENST00000379791.3_Missense_Mutation_p.H415N|AMHR2_ENST00000550311.1_3'UTR	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	510	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	TGCCTTGGCCCATCCTCAAGA	0.602000													30	91					2.24059e-21	3.66643e-21	1	1	0
WISP3	8838	broad.mit.edu	37	6	112390715	112390715	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:112390715C>A	ENST00000361714.1	+	5	1056	c.1011C>A	c.(1009-1011)tgC>tgA	p.C337*	WISP3_ENST00000368663.3_Nonsense_Mutation_p.C296*|WISP3_ENST00000604763.1_Nonsense_Mutation_p.C319*|WISP3_ENST00000230529.5_Nonsense_Mutation_p.C319*|WISP3_ENST00000409166.1_Nonsense_Mutation_p.C95*|WISP3_ENST00000368666.2_Nonsense_Mutation_p.C319*			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	319	CTCK.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		AATTTGATTGCCCAAATGAGG	0.373000													31	46					2.85442e-18	4.51688e-18	1	1	0
TRBV19	28568	broad.mit.edu	37	7	142326802	142326802	+	RNA	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:142326802G>C	ENST00000390393.3	+	0	308																											GTTCAGAAAGGAAGGACAGAA	0.517000													23	111					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122208526	122208526	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:122208526G>A	ENST00000263710.4	-	16	1875	c.1486C>T	c.(1486-1488)Cat>Tat	p.H496Y	CLASP1_ENST00000545861.1_Missense_Mutation_p.H264Y|CLASP1_ENST00000455322.2_Missense_Mutation_p.H496Y|CLASP1_ENST00000541377.1_Missense_Mutation_p.H496Y|CLASP1_ENST00000409078.3_Missense_Mutation_p.H496Y|CLASP1_ENST00000541859.1_Missense_Mutation_p.H265Y|CLASP1_ENST00000397587.3_Missense_Mutation_p.H496Y	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	496					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					TCAGCATCATGTATTCCCTTC	0.299000													24	94					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89416881	89416881	+	RNA	SNP	C	C	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:89416881C>G	ENST00000490686.1	-	0	329																											AATCTTCAGGCTGCAGGCTGC	0.493000													51	89					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087083	100087083	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:100087083G>T	ENST00000423930.1	+	4	1898	c.1739G>T	c.(1738-1740)gGg>gTg	p.G580V	NYAP1_ENST00000454988.1_Missense_Mutation_p.G523V|NYAP1_ENST00000300179.2_Missense_Mutation_p.G580V			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	580																	TGTGGTGTGGGGGCCCCATCC	0.647000													11	48					5.50884e-06	6.29581e-06	1	1	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1101_splice	c.e13-1	p.L368_splice	POLR3B_ENST00000549195.1_3'UTR|POLR3B_ENST00000539066.1_Splice_Site_p.L310_splice	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													4	18					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175738	51175738	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:51175738G>C	ENST00000440970.1	-	2	535	c.104C>G	c.(103-105)gCt>gGt	p.A35G	SALL1_ENST00000251020.4_Missense_Mutation_p.A132G|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	132					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GCTTTTGTTAGCAACCGGGGC	0.602000													6	76					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12223934	12223934	+	Silent	SNP	T	T	C			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:12223934T>C	ENST00000339302.4	+	3	2209	c.1572T>C	c.(1570-1572)caT>caC	p.H524H	ZNF788_ENST00000430298.2_3'UTR|ZNF20_ENST00000600335.1_Intron|ZNF788_ENST00000397759.3_Silent_p.H143H					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						GACTAACTCATATTGGAAAAA	0.378000													5	4					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3747815	3747815	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:3747815C>T	ENST00000541714.2	+	19	2808	c.2346C>T	c.(2344-2346)aaC>aaT	p.N782N	TJP3_ENST00000382008.3_Silent_p.N796N|TJP3_ENST00000587686.1_Silent_p.N801N|TJP3_ENST00000539908.2_Silent_p.N746N|TJP3_ENST00000589378.1_Silent_p.N791N|TJP3_ENST00000262968.9_Silent_p.N815N	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	796						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGGACAACCTAGACCTCC	0.682000													3	10					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122622812	122622812	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr12:122622812C>T	ENST00000319080.6	+	13	2358	c.2226C>T	c.(2224-2226)ctC>ctT	p.L742L	MLXIP_ENST00000538698.1_Silent_p.L349L			Q9HAP2	MLXIP_HUMAN	MLX interacting protein	742					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		TCGACATGCTCAACAGCCTCA	0.562000													8	24					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598321	58598321	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:58598321C>A	ENST00000240727.6	-	5	1096	c.697G>T	c.(697-699)Gac>Tac	p.D233Y	ZSCAN18_ENST00000421612.2_Missense_Mutation_p.D98Y|ZSCAN18_ENST00000600404.1_Missense_Mutation_p.D289Y|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.D233Y	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	233					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TCGGCAGGGTCCAGGTGGCCC	0.632000													12	42					2.32078e-09	3.00173e-09	1	1	0
RBFOX2	23543	broad.mit.edu	37	22	36205961	36205961	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr22:36205961T>A	ENST00000405409.2	-	2	486	c.118A>T	c.(118-120)Aca>Tca	p.T40S	RBFOX2_ENST00000359369.4_Missense_Mutation_p.T20S|RBFOX2_ENST00000416721.2_Missense_Mutation_p.T40S|RBFOX2_ENST00000449924.2_Missense_Mutation_p.T40S|RBFOX2_ENST00000414461.2_Missense_Mutation_p.T40S|RBFOX2_ENST00000397303.2_Missense_Mutation_p.T20S|RBFOX2_ENST00000262829.7_Missense_Mutation_p.T40S|RBFOX2_ENST00000438146.2_Missense_Mutation_p.T110S	NM_001031695.2|NM_001082576.1|NM_001082577.1|NM_014309.2	NP_001026865.1|NP_001076045.1|NP_001076046.1|NP_055124.1	O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	50					estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						CCATACTCTGTGGGAATTCCA	0.537000													42	150					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3806525	3806525	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:3806525C>A	ENST00000225538.3	-	7	992	c.718G>T	c.(718-720)Ggc>Tgc	p.G240C		NM_002558.2	NP_002549.1	P51575	P2RX1_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 1	240					platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	13				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		AAGTTCTGGCCTGACTCTTGC	0.592000													12	36					9.31168e-06	1.05859e-05	1	1	0
ZNF347	84671	broad.mit.edu	37	19	53644927	53644927	+	Missense_Mutation	SNP	C	C	G	rs151248865	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:53644927C>G	ENST00000452676.2	-	5	1583	c.1157G>C	c.(1156-1158)cGt>cCt	p.R386P	ZNF347_ENST00000334197.7_Missense_Mutation_p.R385P|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.R386P	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		TAAGCTTGAACGAGCTCTAAA	0.408000													46	116					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77893691	77893691	+	Missense_Mutation	SNP	G	G	T	rs139600625		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr18:77893691G>T	ENST00000262198.4	+	4	850	c.395G>T	c.(394-396)cGg>cTg	p.R132L		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	132					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GCACCTGTCCGGAAAGTCCAG	0.413000													35	70					1.61788e-16	2.49616e-16	1	1	0
OR2D2	120776	broad.mit.edu	37	11	6913672	6913672	+	Silent	SNP	C	C	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:6913672C>A	ENST00000299459.2	-	1	158	c.60G>T	c.(58-60)ggG>ggT	p.G20G		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CGGTGTGTGGCCCATCAGAGA	0.443000													27	84					2.42023e-17	3.78819e-17	1	1	0
JAM3	83700	broad.mit.edu	37	11	134014888	134014888	+	Splice_Site	SNP	T	T	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:134014888T>A	ENST00000299106.4	+	5	770	c.612_splice	c.e5+1	p.L204_splice	JAM3_ENST00000529443.2_Splice_Site_p.L249_splice|JAM3_ENST00000441717.3_Splice_Site_p.L153_splice|JAM3_ENST00000524969.1_3'UTR			Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3	204	Ig-like C2-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)	10	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		ACAGGCACTTTGGTAAGATCT	0.428000													16	36					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46060665	46060665	+	Silent	SNP	C	C	T			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr13:46060665C>T	ENST00000349995.5	+	8	991	c.879C>T	c.(877-879)ttC>ttT	p.F293F		NM_031431.3	NP_113619.2	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	293					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		ACAATGCCTTCACATTATTTT	0.378000													27	131					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183515266	183515267	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:183515266_183515267insA	ENST00000367537.3	+	18	2680_2681	c.2485_2486insA	c.(2485-2487)aaafs	p.K829fs	SMG7_ENST00000508461.1_Frame_Shift_Ins_p.K804fs|SMG7_ENST00000507469.1_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000347615.2_Frame_Shift_Ins_p.K846fs|SMG7_ENST00000515829.2_Frame_Shift_Ins_p.K800fs|SMG7_ENST00000456731.2_Frame_Shift_Ins_p.K758fs			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	846	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding	p.?(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						GCAGCCTCTAGAAAAAAAAATG	0.450													7	189	---	---	---	---					
COG2	22796	broad.mit.edu	37	1	230795269	230795291	+	Frame_Shift_Del	DEL	ACTGAGAGATGACCTGGAGCTCT	ACTGAGAGATGACCTGGAGCTCT	-	rs142733439	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr1:230795269_230795291delACTGAGAGATGACCTGGAGCTCT	ENST00000366669.4	+	2	247_269	c.132_154delACTGAGAGATGACCTGGAGCTCT	c.(130-156)gaacfs	p.ELRDDLELY44fs	COG2_ENST00000534989.1_5'UTR|COG2_ENST00000366668.3_Frame_Shift_Del_p.ELRDDLELY44fs|COG2_ENST00000535166.1_5'UTR|COG2_ENST00000494371.1_3'UTR	NM_001145036.1|NM_007357.2	NP_001138508.1|NP_031383.1	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	44					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity	p.L45L(1)		NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				AGCTGGAAGAACTGAGAGATGACCTGGAGCTCTACTATAAACT	0.377													15	219	---	---	---	---					
MED15P9	285103	broad.mit.edu	37	2	130894016	130894016	+	RNA	DEL	C	C	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:130894016delC	ENST00000427638.1	+	0	579					NR_033903.1																						CCCCCAACTGCAGCCCCAGGC	0.637													4	8	---	---	---	---					
SCN3A	6328	broad.mit.edu	37	2	165970461	165970461	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr2:165970461delT	ENST00000360093.3	-	20	4025	c.3534delA	c.(3532-3534)ccfs	p.P1178fs	SCN3A_ENST00000409101.3_Frame_Shift_Del_p.P1129fs|SCN3A_ENST00000283254.7_Frame_Shift_Del_p.P1178fs	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1178						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CTTGACAGAATGGAAACTTTT	0.318													40	131	---	---	---	---					
PPID	5481	broad.mit.edu	37	4	159642523	159642524	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr4:159642523_159642524delGA	ENST00000307720.3	-	2	304_305	c.197_198delTC	c.(196-198)cfs	p.L66fs		NM_005038.2	NP_005029.1	Q08752	PPID_HUMAN	peptidylprolyl isomerase D	66	PPIase cyclophilin-type.				protein folding	cytoplasm|intermediate filament cytoskeleton	cyclosporin A binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0159)		CTTTGAAATGGAGAGGTTTCCC	0.391													14	66	---	---	---	---					
MDC1	9656	broad.mit.edu	37	6	30675822	30675825	+	Frame_Shift_Del	DEL	TCTG	TCTG	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr6:30675822_30675825delTCTG	ENST00000376406.3	-	8	3178_3181	c.2531_2534delCAGA	c.(2530-2535)atfs	p.TD844fs	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Intron	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	844				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TCCTGTCACATCTGTCTGTCTTTC	0.456								Other conserved DNA damage response genes					75	348	---	---	---	---					
ZNF800	168850	broad.mit.edu	37	7	127014927	127014928	+	Frame_Shift_Ins	INS	-	-	AA	rs141805822	by1000genomes	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr7:127014927_127014928insAA	ENST00000393313.1	-	5	1053_1054	c.462_463insTT	c.(460-465)ataagtfs	p.S155fs	ZNF800_ENST00000265827.3_Frame_Shift_Ins_p.S155fs|ZNF800_ENST00000393312.1_Frame_Shift_Ins_p.S155fs			Q2TB10	ZN800_HUMAN	zinc finger protein 800	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TCTGTGACTTCAATAGGATTAT	0.371													36	116	---	---	---	---					
MSR1	4481	broad.mit.edu	37	8	16026001	16026001	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:16026001delC	ENST00000350896.3	-	4	793	c.596delG	c.(595-597)gcfs	p.G199fs	MSR1_ENST00000445506.2_Frame_Shift_Del_p.G217fs|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000262101.5_Frame_Shift_Del_p.G199fs|MSR1_ENST00000355282.2_Frame_Shift_Del_p.G199fs|MSR1_ENST00000381998.4_Frame_Shift_Del_p.G199fs	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	199					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity	p.G199D(2)		haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTGGATTTTGCCATTCAGATT	0.413													30	103	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30945377	30945379	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:30945377_30945379delAAG	ENST00000298139.5	+	12	1766_1768	c.1517_1519delAAG	c.(1516-1521)aaa>a	p.KE506del		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	506					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTTCCTACTAaagaagaagaaga	0.360			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				10	164	---	---	---	---					
SLC7A13	157724	broad.mit.edu	37	8	87242454	87242454	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr8:87242454delC	ENST00000297524.3	-	1	156	c.53delG	c.(52-54)gcfs	p.G18fs	SLC7A13_ENST00000419776.2_Frame_Shift_Del_p.G18fs|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	18						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						AAAACTTGTGCCCCACCAATA	0.378													37	127	---	---	---	---					
ITIH2	3698	broad.mit.edu	37	10	7776943	7776965	+	Frame_Shift_Del	DEL	TCTCTAGACCACCACATTGTGAC	TCTCTAGACCACCACATTGTGAC	-	rs143765273		TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:7776943_7776965delTCTCTAGACCACCACATTGTGAC	ENST00000358415.4	+	15	2012_2034	c.1846_1868delTCTCTAGACCACCACATTGTGAC	c.(1846-1869)tfs	p.SLDHHIVT616fs	ITIH2_ENST00000379587.4_Frame_Shift_Del_p.SLDHHIVT605fs	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	616					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CCTGCAGATGTCTCTAGACCACCACATTGTGACTCCGCTGACC	0.565													10	149	---	---	---	---					
KIF20B	9585	broad.mit.edu	37	10	91498335	91498337	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr10:91498335_91498337delAAG	ENST00000416354.1	+	20	3899_3901	c.3827_3829delAAG	c.(3826-3831)aaa>a	p.KE1276del	KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000394289.2_In_Frame_Del_p.KE1246del|KIF20B_ENST00000260753.4_In_Frame_Del_p.KE1206del|KIF20B_ENST00000371728.3_In_Frame_Del_p.KE1246del			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1246					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						CTTCAATTAAAAGAAGAAGAAGA	0.276													9	62	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr11:12316384_12316389delCTCCTA	ENST00000256186.2	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)cca>c	p.PPT469del		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	469	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding	p.T471delT(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.573													4	6	---	---	---	---					
EIF3CL	728689	broad.mit.edu	37	16	28403353	28403355	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr16:28403353_28403355delTCC	ENST00000398943.3	-	9	1021_1023	c.885_887delGGA	c.(883-888)gac>ga	p.ED295del	EIF3CL_ENST00000398944.3_In_Frame_Del_p.ED295del|EIF3CL_ENST00000380876.4_In_Frame_Del_p.ED295del					eukaryotic translation initiation factor 3, subunit C-like																		GCCTTCATTGTCCTCCTCCTCCT	0.547													3	6	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7751762	7751763	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr17:7751762_7751763insG	ENST00000254846.5	+	11	2545_2546	c.2156_2157insG	c.(2155-2157)ggcfs	p.G719fs	KDM6B_ENST00000448097.2_Frame_Shift_Ins_p.G719fs	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	719	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GAAGCAGGCGTGGCCCCCCAAC	0.584													7	161	---	---	---	---					
SMARCA4	6597	broad.mit.edu	37	19	11106903	11106903	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:11106903delG	ENST00000358026.2	+	10	1892	c.1608delG	c.(1606-1608)gafs	p.E536fs	SMARCA4_ENST00000589677.1_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000344626.4_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000590574.1_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000413806.3_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000450717.3_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000541122.2_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000429416.3_Frame_Shift_Del_p.E536fs|SMARCA4_ENST00000444061.3_Frame_Shift_Del_p.E536fs	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	536					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AAGATGAGGAGGGGTACCGCA	0.567			"""F, N, Mis"""		NSCLC								66	116	---	---	---	---					
MYBPC2	4606	broad.mit.edu	37	19	50963366	50963367	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:50963366_50963367insG	ENST00000357701.5	+	24	2912_2913	c.2861_2862insG	c.(2860-2862)cgcfs	p.R954fs		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	954	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GTGGAGTGGCAGGCCCCCAAAG	0.550													8	7	---	---	---	---					
PEG3	5178	broad.mit.edu	37	19	57326214	57326214	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chr19:57326214delC	ENST00000326441.9	-	10	3959	c.3596delG	c.(3595-3597)gtfs	p.G1199fs	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Frame_Shift_Del_p.G1075fs|PEG3_ENST00000593695.1_Frame_Shift_Del_p.G1073fs|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Frame_Shift_Del_p.G1199fs|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1199					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGCAATAAAACCATCATCACA	0.478													43	120	---	---	---	---					
GAGE2D	729408	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	-	TAT			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:49208295_49208296insTAT	ENST00000404720.2	+	2	96_97	c.24_25insTAT	c.(22-27)acatcg>acTATatcg	p.8_9TS>TIS		NM_001098407.1|NM_012196.1	NP_001091877.1|NP_036328.1			G antigen 2D																		GAAGATCGACCTATCGGCCTAG	0.465													10	7	---	---	---	---					
NONO	4841	broad.mit.edu	37	X	70511784	70511787	+	Frame_Shift_Del	DEL	TTCA	TTCA	-			TCGA-86-8674-01A-21D-2393-08	TCGA-86-8674-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b63102c-8d78-4d50-b8cb-21114333de7c	4e7f3670-9963-44ad-8c4b-f0c07720656c	g.chrX:70511784_70511787delTTCA	ENST00000535149.1	+	2	686_689	c.43_46delTTCA	c.(43-48)ttfs	p.FI15fs	NONO_ENST00000276079.8_Frame_Shift_Del_p.FI104fs|NONO_ENST00000373841.1_Frame_Shift_Del_p.FI104fs|NONO_ENST00000373856.3_Frame_Shift_Del_p.FI104fs	NM_001145410.1	NP_001138882.1	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	104					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					AGGCGAAGTCTTCATTCATAAGGA	0.441			T	TFE3	papillary renal cancer								51	89	---	---	---	---					
