Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LYST	1130	broad.mit.edu	37	1	235918847	235918847	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr1:235918847C>T	ENST00000389794.3	-	25	7334	c.7160G>A	c.(7159-7161)cGa>cAa	p.R2387Q	LYST_ENST00000389793.2_Missense_Mutation_p.R2387Q			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2387					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGAGTTCCTCGATGAAGATA	0.373000													15	223					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	22					1	1	1	1	0
CIZ1	25792	broad.mit.edu	37	9	130932312	130932312	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr9:130932312G>A	ENST00000538431.1	-	12	2265	c.2018C>T	c.(2017-2019)aCa>aTa	p.T673I	CIZ1_ENST00000372954.1_Missense_Mutation_p.T593I|CIZ1_ENST00000372938.5_Missense_Mutation_p.T673I|CIZ1_ENST00000476727.2_5'UTR|CIZ1_ENST00000325721.8_Missense_Mutation_p.T644I|CIZ1_ENST00000277465.4_Missense_Mutation_p.T645I|CIZ1_ENST00000372948.3_Missense_Mutation_p.T617I|CIZ1_ENST00000393608.1_Missense_Mutation_p.T673I|CIZ1_ENST00000541172.1_Missense_Mutation_p.T572I|CIZ1_ENST00000357558.5_Missense_Mutation_p.T645I	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	673						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						GTGGTCCTGTGTCCTGCGGTG	0.577000													18	68					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6338316	6338316	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr8:6338316C>A	ENST00000344683.5	+	11	2131	c.2055C>A	c.(2053-2055)caC>caA	p.H685Q		NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	685	BRCT 2.					microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		CCACGACTCACGTGCTTTCCG	0.507000													27	87					3.01185e-09	3.27375e-09	1	1	0
TBC1D8B	54885	broad.mit.edu	37	X	106046175	106046175	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:106046175G>A	ENST00000357242.5	+	1	266	c.92G>A	c.(91-93)cGt>cAt	p.R31H	TBC1D8B_ENST00000310452.2_Missense_Mutation_p.R31H|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.R31H|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.R31H	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	31						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTGCAGCGGCGTCGGGGCTAC	0.582000													5	86					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61537323	61537323	+	Missense_Mutation	SNP	T	T	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr20:61537323T>C	ENST00000266070.4	-	6	1829	c.1504A>G	c.(1504-1506)Acg>Gcg	p.T502A	DIDO1_ENST00000370368.1_Missense_Mutation_p.T502A|DIDO1_ENST00000354665.4_Missense_Mutation_p.T502A|DIDO1_ENST00000370366.1_Missense_Mutation_p.T502A|DIDO1_ENST00000395343.1_Missense_Mutation_p.T502A|DIDO1_ENST00000395335.2_Missense_Mutation_p.T502A|DIDO1_ENST00000395340.1_Missense_Mutation_p.T502A|DIDO1_ENST00000370371.4_Missense_Mutation_p.T502A|DIDO1_ENST00000266071.5_Missense_Mutation_p.T502A	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	502					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CACGACGGCGTGCTGCTCTCA	0.527000													29	126					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133376380	133376380	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr9:133376380G>A	ENST00000372394.1	+	16	1692	c.1211G>A	c.(1210-1212)cGt>cAt	p.R404H	ASS1_ENST00000352480.5_Missense_Mutation_p.R404H|ASS1_ENST00000372393.3_Missense_Mutation_p.R404H			P00966	ASSY_HUMAN	argininosuccinate synthase 1	404					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	GAATATCATCGTCTCCAGAGC	0.438000													10	84					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953137	56953137	+	Silent	SNP	T	T	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr19:56953137T>C	ENST00000504904.3	-	7	1946	c.1227A>G	c.(1225-1227)acA>acG	p.T409T	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000342634.3_Silent_p.T537T|ZNF667_ENST00000292069.6_Silent_p.T409T			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TCTTTTTCTTTGTATGAACTT	0.328000													9	34					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834403	101834403	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr5:101834403C>T	ENST00000506729.1	-	1	317	c.146G>A	c.(145-147)cGg>cAg	p.R49Q	SLCO6A1_ENST00000513675.1_Missense_Mutation_p.R49Q|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.R49Q|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.R49Q|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.R49Q			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	49						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TCTCAGATACCGGTGTTTTTT	0.572000													11	387					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73051292	73051292	+	Silent	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr10:73051292C>T	ENST00000335350.6	+	10	1814	c.1398C>T	c.(1396-1398)atC>atT	p.I466I	UNC5B_ENST00000373192.4_Silent_p.I455I	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	466					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CCGACAAAATCCCCATGACCA	0.637000													7	133					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													5	187					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39644549	39644549	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr8:39644549C>T	ENST00000265708.4	-	10	938	c.835G>A	c.(835-837)Ggt>Agt	p.G279S	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000347580.4_Missense_Mutation_p.G260S|ADAM2_ENST00000521880.1_Missense_Mutation_p.G279S	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	279	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AAGGTTGCACCAACATAATTT	0.284000													9	56					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909909	36909909	+	Missense_Mutation	SNP	T	T	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr13:36909909T>G	ENST00000451493.1	-	2	276	c.59A>C	c.(58-60)tAt>tCt	p.Y20S	SPG20_ENST00000355182.4_Missense_Mutation_p.Y20S|SPG20_ENST00000494062.2_Missense_Mutation_p.Y20S|SPG20_ENST00000438666.2_Missense_Mutation_p.Y20S|SPG20_ENST00000495510.1_5'UTR	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	20	MIT.				cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		GGCCTTCTTATATGCTTCTCT	0.358000													5	98					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48549836	48549836	+	Silent	SNP	G	G	T	rs139598111		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr17:48549836G>T	ENST00000427954.2	+	13	1489	c.1446G>T	c.(1444-1446)acG>acT	p.T482T	ACSF2_ENST00000300441.4_Silent_p.T457T|ACSF2_ENST00000502667.1_Silent_p.T444T|ACSF2_ENST00000506085.1_Intron|ACSF2_ENST00000504392.1_Silent_p.T414T|ACSF2_ENST00000541920.1_Silent_p.T297T			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	457					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AGCTGAACACGCCCGGGGAGC	0.587000													13	56					2.27111e-07	2.39906e-07	1	1	0
CACNA1F	778	broad.mit.edu	37	X	49063212	49063212	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:49063212C>T	ENST00000376265.2	-	45	5430	c.5369G>A	c.(5368-5370)cGt>cAt	p.R1790H	CACNA1F_ENST00000323022.5_Missense_Mutation_p.R1779H|CACNA1F_ENST00000376251.1_Missense_Mutation_p.R1725H	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1790					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity	p.R1790H(1)		autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GGGCAGCAGACGGCGGCGTGG	0.612000													6	92					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114901025	114901025	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr10:114901025C>T	ENST00000355995.4	+	6	1142	c.635C>T	c.(634-636)aCg>aTg	p.T212M	TCF7L2_ENST00000543371.1_Missense_Mutation_p.T212M|TCF7L2_ENST00000536810.1_Missense_Mutation_p.T212M|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000534894.1_Missense_Mutation_p.T212M|TCF7L2_ENST00000349937.2_Missense_Mutation_p.T212M|TCF7L2_ENST00000352065.5_Missense_Mutation_p.T189M|TCF7L2_ENST00000538897.1_Missense_Mutation_p.T212M|TCF7L2_ENST00000355717.4_Missense_Mutation_p.T236M|TCF7L2_ENST00000369397.4_Missense_Mutation_p.T189M|TCF7L2_ENST00000545257.1_Missense_Mutation_p.T212M|TCF7L2_ENST00000369395.1_Missense_Mutation_p.T237M			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	212	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		GAACACTTCACGCCGGGAAAC	0.577000			T	VTI1A	colorectal								11	122					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763849	82763849	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:82763849G>A	ENST00000373200.2	+	1	581	c.517G>A	c.(517-519)Ggc>Agc	p.G173S	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	173					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						CCCGGATCACGGCGAACTGGG	0.607000													5	21					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75614328	75614328	+	Silent	SNP	A	A	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr1:75614328A>G	ENST00000294638.5	+	8	1435	c.771A>G	c.(769-771)aaA>aaG	p.K257K	LHX8_ENST00000356261.3_Silent_p.K247K	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	257						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						CACTCCAGAAATTGGCAGAAA	0.358000													6	76					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555664	155555664	+	Missense_Mutation	SNP	A	A	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr2:155555664A>T	ENST00000295101.2	+	1	854	c.377A>T	c.(376-378)aAt>aTt	p.N126I	KCNJ3_ENST00000544049.1_Missense_Mutation_p.N126I	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	126					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TGCGTGGCCAATGTCTATAAC	0.572000													4	75					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96058361	96058361	+	Missense_Mutation	SNP	A	A	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr10:96058361A>G	ENST00000260766.3	+	24	6027	c.5393A>G	c.(5392-5394)aAc>aGc	p.N1798S	PLCE1_ENST00000371385.3_Missense_Mutation_p.N1490S|PLCE1_ENST00000371380.2_Missense_Mutation_p.N1798S|PLCE1_ENST00000371375.1_Missense_Mutation_p.N1490S	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1798	PI-PLC Y-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GACTCTTCCAACCCGAACCCC	0.567000													5	167					0	0	1	0	0
PPP4C	5531	broad.mit.edu	37	16	30094153	30094153	+	Silent	SNP	G	G	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:30094153G>T	ENST00000279387.7	+	5	456	c.288G>T	c.(286-288)ctG>ctT	p.L96L	PPP4C_ENST00000561610.1_Silent_p.L96L	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	96					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						CGTTCCTCCTGCTGCTGGCAC	0.612000													23	64					3.7963e-18	4.5923e-18	1	1	0
CNGA4	1262	broad.mit.edu	37	11	6262729	6262729	+	Missense_Mutation	SNP	G	G	T	rs144134835		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr11:6262729G>T	ENST00000379936.2	+	5	1101	c.986G>T	c.(985-987)cGg>cTg	p.R329L	CNGA4_ENST00000533426.1_Missense_Mutation_p.R98L	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	329					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGCCTGAGCGGCTGCGGGCA	0.557000													13	107					2.27111e-07	2.39906e-07	1	1	0
ZNF23	7571	broad.mit.edu	37	16	71483109	71483109	+	Silent	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:71483109G>A	ENST00000393539.2	-	6	1632	c.819C>T	c.(817-819)atC>atT	p.I273I	ZNF23_ENST00000428724.2_Silent_p.I215I|RP11-510M2.10_ENST00000576258.1_RNA|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000539742.1_5'UTR|ZNF23_ENST00000564528.1_Silent_p.I215I|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000357254.4_Silent_p.I273I|ZNF23_ENST00000417828.1_Silent_p.I273I|ZNF23_ENST00000497160.1_3'UTR	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CTCCCGTATGGATTCTCTGAT	0.468000													12	110					0	0	1	0	0
R3HDM4	91300	broad.mit.edu	37	19	901461	901461	+	Silent	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr19:901461G>A	ENST00000361574.5	-	3	385	c.312C>T	c.(310-312)ggC>ggT	p.G104G	R3HDM4_ENST00000587975.1_Silent_p.G83G	NM_138774.3	NP_620129.2	Q96D70	CS022_HUMAN	R3H domain containing 4	104						nucleus	nucleic acid binding										CGGCAAAGATGCCTGGTGATG	0.652000													7	13					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141033816	141033816	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr5:141033816C>A	ENST00000239440.4	-	33	4401	c.4336G>T	c.(4336-4338)Gat>Tat	p.D1446Y	ARAP3_ENST00000508305.1_Missense_Mutation_p.D1277Y|ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000513878.1_Missense_Mutation_p.D1095Y	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1446					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding	p.D1446Y(1)		NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						AAGGGTTGATCCAATGACTTC	0.607000													4	116					1	1	1	1	0
PCGF5	84333	broad.mit.edu	37	10	92982639	92982639	+	Missense_Mutation	SNP	A	A	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr10:92982639A>T	ENST00000336126.5	+	2	243	c.11A>T	c.(10-12)cAa>cTa	p.Q4L	PCGF5_ENST00000543648.1_Missense_Mutation_p.Q4L|PCGF5_ENST00000371687.2_Missense_Mutation_p.Q4L|PCGF5_ENST00000490164.1_3'UTR	NM_001257101.1|NM_032373.4	NP_001244030.1|NP_115749.2	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)	12						ATGGCTACCCAAAGGAAACAC	0.453000													16	46					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42866330	42866330	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr19:42866330C>T	ENST00000334370.4	+	32	6243	c.5608C>T	c.(5608-5610)Cgc>Tgc	p.R1870C	MEGF8_ENST00000251268.6_Missense_Mutation_p.R1937C	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1937						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTGCCTGGCCCGCCATCCTCG	0.657000													5	24					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70338468	70338468	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr11:70338468C>A	ENST00000338508.4	-	29	2413	c.2414G>T	c.(2413-2415)cGg>cTg	p.R805L	SHANK2_ENST00000409530.1_Missense_Mutation_p.R215L|SHANK2_ENST00000423696.2_Missense_Mutation_p.R425L|SHANK2_ENST00000409161.1_Missense_Mutation_p.R208L|SHANK2_ENST00000357171.3_Missense_Mutation_p.R216L|SHANK2_ENST00000449833.2_Missense_Mutation_p.R209L|SHANK2_ENST00000449116.2_Missense_Mutation_p.R206L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	425					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CGGGAAGCACCGGCTGCTGGG	0.672000													9	52					1.12685e-05	1.1738e-05	1	1	0
MCM3	4172	broad.mit.edu	37	6	52144355	52144355	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:52144355C>A	ENST00000596288.1	-	5	736	c.709G>T	c.(709-711)Gtc>Ttc	p.V237F	MCM3_ENST00000419835.2_Missense_Mutation_p.V146F|MCM3_ENST00000229854.7_Missense_Mutation_p.V192F	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	192					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					TCCTTGTAGACAGAAAGGCCA	0.527000													12	147					4.36969e-10	4.89144e-10	1	1	0
OR4D9	390199	broad.mit.edu	37	11	59282725	59282725	+	Missense_Mutation	SNP	T	T	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr11:59282725T>A	ENST00000329328.3	+	1	340	c.340T>A	c.(340-342)Tct>Act	p.S114T		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						AGACGTTTTTTCTCTCTCTGT	0.502000													10	80					0	0	1	0	0
CCNB2	9133	broad.mit.edu	37	15	59406798	59406798	+	Silent	SNP	T	T	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr15:59406798T>C	ENST00000288207.2	+	4	614	c.423T>C	c.(421-423)taT>taC	p.Y141Y	CCNB2_ENST00000559622.1_Silent_p.Y60Y	NM_004701.3	NP_004692.1	O95067	CCNB2_HUMAN	cyclin B2	141					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding			kidney(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9						TCTATCAGTATCTCAGGCAGC	0.443000													5	64					0	0	1	0	0
GLA	2717	broad.mit.edu	37	X	100662861	100662861	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:100662861C>A	ENST00000218516.3	-	1	52	c.31G>T	c.(31-33)Ggc>Tgc	p.G11C	RPL36A-HNRNPH2_ENST00000409170.3_Intron	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	11					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	AGCGCGCAGCCCAGATGTAGT	0.577000													27	115					3.73148e-12	4.30555e-12	1	1	0
GPR50	9248	broad.mit.edu	37	X	150349712	150349712	+	Missense_Mutation	SNP	C	C	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:150349712C>A	ENST00000218316.3	+	2	1726	c.1657C>A	c.(1657-1659)Cct>Act	p.P553T		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	553	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CATTGCCCACCCTGTGTCTGA	0.637000													35	157					1.36615e-20	1.67969e-20	1	1	0
NBEAL2	23218	broad.mit.edu	37	3	47041640	47041640	+	Missense_Mutation	SNP	C	C	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr3:47041640C>G	ENST00000450053.3	+	27	4230	c.4051C>G	c.(4051-4053)Cca>Gca	p.P1351A	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Intron	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1351							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGCTCTCTCCCCATTCTGCAC	0.602000													41	150					0	0	1	0	0
NKX3-1	4824	broad.mit.edu	37	8	23539110	23539110	+	Nonsense_Mutation	SNP	G	G	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr8:23539110G>T	ENST00000380871.4	-	2	366	c.329C>A	c.(328-330)tCa>tAa	p.S110*	NKX3-1_ENST00000523261.1_Nonsense_Mutation_p.S35*	NM_006167.3	NP_006158.2	Q99801	NKX31_HUMAN	NK3 homeobox 1	110					negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding			large_intestine(3)|lung(4)|prostate(5)|skin(2)	14		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		AAGGGCGCCTGAAGTGTTTTC	0.542000													40	114					2.40228e-13	2.81517e-13	1	1	0
MXRA5	25878	broad.mit.edu	37	X	3242278	3242278	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:3242278C>T	ENST00000217939.6	-	5	1602	c.1448G>A	c.(1447-1449)gGa>gAa	p.G483E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	483	Ig-like C2-type 1.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGCACAGCTCCACTAGGCTC	0.498000													30	241					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29884864	29884864	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr22:29884864G>A	ENST00000310624.6	+	4	1268	c.1235G>A	c.(1234-1236)cGg>cAg	p.R412Q		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	412	Coil 2B.|Rod.				cell death|nervous system development	neurofilament		p.R412L(1)		cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GAAGAGTGTCGGATTGGCTTT	0.448000													34	77					0	0	1	0	0
ASPA	443	broad.mit.edu	37	17	3402307	3402307	+	Silent	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr17:3402307C>T	ENST00000263080.2	+	6	1025	c.867C>T	c.(865-867)taC>taT	p.Y289Y	SPATA22_ENST00000541913.1_Intron|ASPA_ENST00000456349.2_Silent_p.Y289Y	NM_000049.2	NP_000040.1	P45381	ACY2_HUMAN	aspartoacylase	289					aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding	p.Y289Y(1)		breast(2)|endometrium(2)|large_intestine(6)|lung(5)|stomach(1)|urinary_tract(1)	17					L-Aspartic Acid(DB00128)	CCGCATATTACGAAAAGAAAG	0.433000													5	33					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													5	71					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4242776	4242776	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:4242776C>T	ENST00000399609.3	-	6	812	c.800G>A	c.(799-801)cGg>cAg	p.R267Q	SRL_ENST00000537996.1_Missense_Mutation_p.R225Q	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	726	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						CCCGTAAACCCGCATGAGCAT	0.552000													6	111					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128471489	128471489	+	Silent	SNP	A	A	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr2:128471489A>C	ENST00000322313.4	-	18	3134	c.2976T>G	c.(2974-2976)ggT>ggG	p.G992G		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	992					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AGTCCTGGCCACCCCGGAAAG	0.662000													17	179					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108032653	108032653	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr11:108032653G>A	ENST00000278612.8	-	17	3265	c.3160C>T	c.(3160-3162)Cca>Tca	p.P1054S		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	1054	Required for acceleration of G1 phase.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TTAGCAGCTGGAACTATACTC	0.443000													12	91					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30623911	30623911	+	RNA	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr8:30623911G>A	ENST00000519246.1	+	0	1012							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						GACCAACTAGGAAAGAAGGGA	0.498000													5	14					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729785	62729785	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr20:62729785C>T	ENST00000349451.3	+	6	1158	c.746C>T	c.(745-747)tCg>tTg	p.S249L	OPRL1_ENST00000336866.2_Missense_Mutation_p.S249L|OPRL1_ENST00000355631.4_Missense_Mutation_p.S249L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	249					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					CGCCTGCTCTCGGGCTCCCGA	0.632000													5	157					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801402	196801402	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr2:196801402G>A	ENST00000312428.6	-	20	3293	c.3193C>T	c.(3193-3195)Cgc>Tgc	p.R1065C		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1065	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAAAAGAGGCGTTTCTTTTCC	0.343000													21	52					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31857352	31857352	+	Missense_Mutation	SNP	G	G	C	rs115631257	byFrequency	TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:31857352G>C	ENST00000395728.3	-	7	1062	c.1063C>G	c.(1063-1065)Cta>Gta	p.L355V	EHMT2_ENST00000375537.4_Missense_Mutation_p.L298V|EHMT2_ENST00000375528.4_Missense_Mutation_p.L355V|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375530.4_Missense_Mutation_p.L298V			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	298					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						tcttcACTTAGTTGTTCAGTT	0.483000													29	102					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													4	81					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230744779	230744779	+	Missense_Mutation	SNP	T	T	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr2:230744779T>C	ENST00000283943.5	-	2	195	c.17A>G	c.(16-18)aAt>aGt	p.N6S	TRIP12_ENST00000543084.1_Missense_Mutation_p.N6S|TRIP12_ENST00000409677.1_Missense_Mutation_p.N6S|TRIP12_ENST00000389045.3_Missense_Mutation_p.N6S|TRIP12_ENST00000389044.4_Missense_Mutation_p.N6S	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	6					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGGATTGTTATTAGGCCGGTT	0.438000													30	80					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y|FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													4	107					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260239	44260239	+	Silent	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr18:44260239G>A	ENST00000315087.7	-	7	1557	c.897C>T	c.(895-897)atC>atT	p.I299I	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Silent_p.I268I|ST8SIA5_ENST00000538168.1_Silent_p.I335I	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	299					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						GGCCGGTGCTGATGCGCTTGG	0.622000													30	81					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131517741	131517741	+	Missense_Mutation	SNP	C	C	T	rs150727016	byFrequency	TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr9:131517741C>T	ENST00000291900.2	-	2	510	c.104G>A	c.(103-105)cGg>cAg	p.R35Q	ZER1_ENST00000494461.1_Intron	NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	35					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						CGGATGTAGCCGCAGGGTCTC	0.607000													6	173					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30993189	30993189	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr2:30993189C>T	ENST00000295055.8	-	5	690	c.514G>A	c.(514-516)Gcc>Acc	p.A172T	CAPN13_ENST00000534090.2_Missense_Mutation_p.A172T|CAPN13_ENST00000465960.2_5'UTR	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	172	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TTGGCATAGGCCTTCTCCAGC	0.557000													5	75					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98165089	98165089	+	Silent	SNP	G	G	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr10:98165089G>T	ENST00000357947.3	-	10	1392	c.1167C>A	c.(1165-1167)atC>atA	p.I389I	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	389	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGTTTAATACGATCTGTAAAG	0.433000													33	100					1.61788e-16	1.92605e-16	1	1	0
ARL6IP1	23204	broad.mit.edu	37	16	18812771	18812771	+	Missense_Mutation	SNP	A	A	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:18812771A>C	ENST00000304414.7	-	1	229	c.18T>G	c.(16-18)aaT>aaG	p.N6K	ARL6IP1_ENST00000562819.1_Missense_Mutation_p.N6K|RP11-1035H13.3_ENST00000567078.2_Missense_Mutation_p.N6K	NM_015161.1	NP_055976.1	Q15041	AR6P1_HUMAN	ADP-ribosylation factor-like 6 interacting protein 1	6						integral to membrane	protein binding			breast(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(1)	11						TGGTGCTGCGATTATCTCCCT	0.657000													7	25					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128297829	128297829	+	Silent	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:128297829C>T	ENST00000368227.3	-	28	4359	c.3993G>A	c.(3991-3993)cgG>cgA	p.R1331R	PTPRK_ENST00000368210.3_Silent_p.R1332R|PTPRK_ENST00000368215.3_Silent_p.R1313R|PTPRK_ENST00000368213.5_Silent_p.R1320R|PTPRK_ENST00000368226.4_Silent_p.R1314R|PTPRK_ENST00000368207.3_Silent_p.R1346R|PTPRK_ENST00000532331.1_Silent_p.R1336R			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1313	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCCTAAAAATCCGGTTGATCA	0.428000													10	26					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	81					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107517465	107517465	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr3:107517465G>A	ENST00000415149.2	+	15	2686	c.2359G>A	c.(2359-2361)Gaa>Aaa	p.E787K	BBX_ENST00000325805.8_Missense_Mutation_p.E817K|BBX_ENST00000473542.1_3'UTR|BBX_ENST00000416476.2_Silent_p.K480K|BBX_ENST00000402543.1_Missense_Mutation_p.E767K|BBX_ENST00000406780.1_Missense_Mutation_p.E787K	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AACAACGCAAGAACCTTTGGT	0.448000													9	45					0	0	1	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47290724	47290724	+	Silent	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr22:47290724G>A	ENST00000337137.4	+	7	1048	c.882G>A	c.(880-882)ctG>ctA	p.L294L	TBC1D22A_ENST00000406733.1_Silent_p.L247L|TBC1D22A_ENST00000355704.3_Silent_p.L216L|TBC1D22A_ENST00000380995.1_Silent_p.L247L|TBC1D22A_ENST00000407381.3_Silent_p.L235L	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	294	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		CGTTGATCCTGCAGCCCAAGG	0.547000													29	107					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149501578	149501578	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr5:149501578C>T	ENST00000261799.4	-	16	2678	c.2209G>A	c.(2209-2211)Gac>Aac	p.D737N		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	737	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TAGCCACCGTCGCTCTCCCCG	0.577000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								6	59					0	0	1	0	0
NEU1	4758	broad.mit.edu	37	6	31829823	31829823	+	Missense_Mutation	SNP	G	G	C			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:31829823G>C	ENST00000375631.4	-	2	434	c.305C>G	c.(304-306)tCc>tGc	p.S102C		NM_000434.3	NP_000425.1	Q99519	NEUR1_HUMAN	sialidase 1 (lysosomal sialidase)	102						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10					Oseltamivir(DB00198)|Zanamivir(DB00558)	CCCCTCATCGGATGAGGACAT	0.597000													21	83					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17235071	17235071	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:17235071G>A	ENST00000261381.6	-	7	1610	c.1526C>T	c.(1525-1527)tCc>tTc	p.S509F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	509					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ATCGTCTGTGGAGAAGGTCAC	0.537000													80	347					0	0	1	0	0
VSIG1	340547	broad.mit.edu	37	X	107310293	107310293	+	Missense_Mutation	SNP	A	A	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chrX:107310293A>G	ENST00000415430.3	+	4	610	c.449A>G	c.(448-450)tAc>tGc	p.Y150C	VSIG1_ENST00000485533.1_3'UTR|VSIG1_ENST00000217957.5_Missense_Mutation_p.Y114C	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	114	Ig-like C2-type 2.					integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						AGTGGAATTTACATCTGCGAT	0.448000													56	199					0	0	1	0	0
PCED1A	64773	broad.mit.edu	37	20	2816300	2816300	+	Silent	SNP	G	G	T			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr20:2816300G>T	ENST00000360652.2	-	8	1675	c.1173C>A	c.(1171-1173)ggC>ggA	p.G391G	PCED1A_ENST00000356872.3_Silent_p.G340G	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		GGGGATTAGGGCCAGGGATTG	0.592000													22	116					6.44725e-10	7.11094e-10	1	1	0
EMC3	55831	broad.mit.edu	37	3	10049093	10049094	+	RNA	INS	-	-	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr3:10049093_10049094insG	ENST00000383808.2	-	0	904_905																											GGGTCAGTGGCGGGGTGTGGTC	0.589													7	113	---	---	---	---					
HES1	3280	broad.mit.edu	37	3	193854779	193854780	+	In_Frame_Ins	INS	-	-	GAC			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr3:193854779_193854780insGAC	ENST00000232424.3	+	3	470_471	c.234_235insGAC	c.(232-237)gcacat>gcGACacat	p.78_79AH>ATH		NM_005524.3	NP_005515.1	Q14469	HES1_HUMAN	hes family bHLH transcription factor 1	78	Helix-loop-helix motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		TGGAGAAGGCGGACATTCTGGA	0.639													12	113	---	---	---	---					
NKD2	85409	broad.mit.edu	37	5	1038447	1038449	+	In_Frame_Del	DEL	CAC	CAC	-	rs3840989		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr5:1038447_1038449delCAC	ENST00000296849.5	+	10	1544_1546	c.1315_1317delCAC	c.(1315-1317)del	p.H447del	NKD2_ENST00000274150.4_3'UTR|NKD2_ENST00000382730.2_In_Frame_Del_p.AP78del	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	447	His-rich.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			ccaccacgagcaccaccaccacc	0.690													4	6	---	---	---	---					
ZNF608	57507	broad.mit.edu	37	5	124079813	124079815	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr5:124079813_124079815delCTC	ENST00000306315.5	-	1	1303_1305	c.868_870delGAG	c.(868-870)del	p.E290del	ZNF608_ENST00000504926.1_Intron	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	290						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCTGTGGCTCTCCTCCTCCTCC	0.522													7	386	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939825	31939826	+	Frame_Shift_Ins	INS	-	-	G			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr6:31939825_31939826insG	ENST00000375331.2	+	1	218_219	c.52_53insG	c.(52-54)ggcfs	p.G18fs	DOM3Z_ENST00000478221.1_5'UTR|DOM3Z_ENST00000337523.5_5'UTR|STK19_ENST00000375333.2_Frame_Shift_Ins_p.G18fs|DOM3Z_ENST00000375349.3_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	18						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GCGACAGTGGCGGGCAAACCCC	0.634													9	253	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75142141	75142142	+	RNA	INS	-	-	A	rs35519730		TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr7:75142141_75142142insA	ENST00000418756.1	-	0	991					NR_028059.1															lung(1)	1						gtctcaaaaagaaaaaaaaaaa	0.421													3	6	---	---	---	---					
AC006988.1	0	broad.mit.edu	37	7	88269891	88269891	+	RNA	DEL	T	T	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr7:88269891delT	ENST00000390184.1	+	0	57																											GAAGGAGCACTTTTTTTTTTT	0.313													2	4	---	---	---	---					
TENC1	23371	broad.mit.edu	37	12	53453642	53453642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr12:53453642delG	ENST00000314250.6	+	18	2507	c.2217delG	c.(2215-2217)ttfs	p.L739fs	TENC1_ENST00000552570.1_Frame_Shift_Del_p.L739fs|TENC1_ENST00000549700.1_Frame_Shift_Del_p.L739fs|TENC1_ENST00000546602.1_Frame_Shift_Del_p.L739fs|TENC1_ENST00000379902.3_Frame_Shift_Del_p.L615fs|TENC1_ENST00000451358.1_Frame_Shift_Del_p.L729fs|TENC1_ENST00000314276.3_Frame_Shift_Del_p.L749fs	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	739	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CTCTGCTCTTGCCTGCCTGTG	0.662													13	81	---	---	---	---					
VPS13C	54832	broad.mit.edu	37	15	62210398	62210398	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr15:62210398delA	ENST00000261517.5	-	59	7770	c.7697delT	c.(7696-7698)cafs	p.L2567fs	VPS13C_ENST00000395896.4_Frame_Shift_Del_p.L2567fs|VPS13C_ENST00000395898.3_Frame_Shift_Del_p.L2524fs|VPS13C_ENST00000249837.3_Frame_Shift_Del_p.L2524fs	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2567					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GCGCTCCAATAGCTTAACATT	0.294													17	111	---	---	---	---					
ABCA17P	650655	broad.mit.edu	37	16	2436255	2436255	+	RNA	DEL	A	A	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr16:2436255delA	ENST00000469908.1	+	0	1510					NR_003574.1																						CGCAGGCTCCAAGGTGCGGCG	0.612													21	75	---	---	---	---					
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr21:10944697delA	ENST00000298232.7	-	10	850	c.483delT	c.(481-483)ttfs	p.F161fs	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Frame_Shift_Del_p.F141fs|TPTE_ENST00000361285.4_Frame_Shift_Del_p.F179fs	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299													7	268	---	---	---	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-91-8497-01A-11D-2393-08	TCGA-91-8497-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ac653c9-a79a-4547-acd7-34d80bfebc39	0fee9621-64d5-40c0-a8ee-3dd18b108915	g.chr22:41650469_41650471delTCC	ENST00000455915.2	-	10	2570_2572	c.1101_1103delGGA	c.(1099-1104)gaa>ga	p.EE367del	RANGAP1_ENST00000405486.1_In_Frame_Del_p.EE367del|RANGAP1_ENST00000407260.4_In_Frame_Del_p.EE312del|RANGAP1_ENST00000356244.3_In_Frame_Del_p.EE367del			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ctcttctccttcctcctcctcct	0.562													7	185	---	---	---	---					
