Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADCY5	111	broad.mit.edu	37	3	123010222	123010222	+	Splice_Site	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:123010222G>T	ENST00000462833.1	-	18	4277	c.3063_splice	c.e18-1	p.A1022_splice	ADCY5_ENST00000309879.5_Splice_Site_p.A672_splice|ADCY5_ENST00000491190.1_Splice_Site_p.A680_splice	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1022					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CTCCTCTGTGGCCTGAGAGAA	0.607000													5	35					0.0215528	0.0231692	0.021553	1	0
KIAA1551	55196	broad.mit.edu	37	12	32134631	32134631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:32134631C>T	ENST00000312561.4	+	4	1156	c.742C>T	c.(742-744)Cag>Tag	p.Q248*	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		TAAAAATAGTCAGCTTCTAAA	0.393000													6	60					0	0	0.001984	0	0
KCNB2	9312	broad.mit.edu	37	8	73848226	73848226	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:73848226C>A	ENST00000523207.1	+	3	1224	c.636C>A	c.(634-636)ctC>ctA	p.L212L		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	212					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CTTTGTCTCTCAATACGCTGC	0.473000													62	178					6.5469e-37	1.13744e-36	0.014410	1	0
URGCP	55665	broad.mit.edu	37	7	43917298	43917298	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:43917298C>A	ENST00000336086.6	-	4	3871	c.1635G>T	c.(1633-1635)acG>acT	p.T545T	URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000447717.3_Silent_p.T545T|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000443736.1_Silent_p.T545T|URGCP_ENST00000402306.3_Silent_p.T579T|URGCP_ENST00000453200.1_Silent_p.T588T|URGCP_ENST00000223341.7_Silent_p.T545T			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	588					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGGTGAGAAGCGTCTCCGGAG	0.647000													12	67					0.00185496	0.00208531	0.016723	1	0
PTPRM	5797	broad.mit.edu	37	18	8384599	8384599	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:8384599A>T	ENST00000332175.8	+	28	4957	c.3920A>T	c.(3919-3921)cAc>cTc	p.H1307L	PTPRM_ENST00000400060.4_Missense_Mutation_p.H1321L|PTPRM_ENST00000400053.4_Missense_Mutation_p.H1245L|PTPRM_ENST00000444013.1_Missense_Mutation_p.H1094L|PTPRM_ENST00000580170.1_Missense_Mutation_p.H1320L	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1307	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GTACACAGACACGGCCCCATC	0.453000													19	87					0	0	0.014323	0	0
TRAK1	22906	broad.mit.edu	37	3	42201878	42201878	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:42201878G>A	ENST00000396175.1	+	1	218	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	TRAK1_ENST00000327628.5_Intron|TRAK1_ENST00000449246.1_Intron|TRAK1_ENST00000487159.1_Intron|TRAK1_ENST00000341421.3_Missense_Mutation_p.E9K			Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	0					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						CAAGGGCGGGGAAGAAGAATG	0.552000													10	145					0	0	0.010729	0	0
PLK2	10769	broad.mit.edu	37	5	57750850	57750850	+	Splice_Site	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:57750850T>C	ENST00000274289.3	-	13	2056		c.e13-2		PLK2_ENST00000502671.1_Intron	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2						positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ATCTCCACCCTGGAAGAGATT	0.403000													16	103					0	0	0.004990	0	0
CHD8	57680	broad.mit.edu	37	14	21873479	21873479	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:21873479C>A	ENST00000399982.2	-	15	3260	c.3196G>T	c.(3196-3198)Gag>Tag	p.E1066*	CHD8_ENST00000557364.1_Nonsense_Mutation_p.E1066*|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Nonsense_Mutation_p.E787*	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1066					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AAATTCTTCTCCAAAATAGCC	0.408000													5	14					8.12818e-05	9.77656e-05	0.001984	1	0
SFSWAP	6433	broad.mit.edu	37	12	132281798	132281798	+	Silent	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:132281798A>G	ENST00000261674.4	+	16	2751	c.2610A>G	c.(2608-2610)tcA>tcG	p.S870S	SFSWAP_ENST00000539506.1_3'UTR|SFSWAP_ENST00000541286.1_Silent_p.S922S	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	870	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						AGTCGGTGTCACCCAGCAAGC	0.672000													16	77					0	0	0.028581	0	0
SETX	23064	broad.mit.edu	37	9	135210025	135210025	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:135210025T>A	ENST00000372169.2	-	7	990	c.808A>T	c.(808-810)Ata>Tta	p.I270L	SETX_ENST00000224140.5_Missense_Mutation_p.I270L|SETX_ENST00000393220.1_Missense_Mutation_p.I270L			Q7Z333	SETX_HUMAN	senataxin	270					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GTGTGAAGTATCGATTGCATA	0.373000													11	68					0	0	0.016723	0	0
HEATR1	55127	broad.mit.edu	37	1	236734872	236734872	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:236734872G>T	ENST00000366582.3	-	27	3936	c.3822C>A	c.(3820-3822)ccC>ccA	p.P1274P	HEATR1_ENST00000366581.2_Silent_p.P1193P	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1274					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACCTACCTTTGGGTATTTTGC	0.393000													5	74					0.0215528	0.0231692	0.021553	1	0
CELSR1	9620	broad.mit.edu	37	22	46780486	46780486	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr22:46780486G>A	ENST00000262738.3	-	20	6836	c.6837C>T	c.(6835-6837)tcC>tcT	p.S2279S		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2279					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGGAGACGGAGGACTCCAGCT	0.552000													8	24					0	0	0.003080	0	0
LILRB5	10990	broad.mit.edu	37	19	54760503	54760503	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:54760503G>T	ENST00000450632.1	-	3	281	c.204C>A	c.(202-204)gcC>gcA	p.A68A	LILRB5_ENST00000449561.2_Silent_p.A68A|LILRB5_ENST00000345866.6_Silent_p.A68A|LILRB5_ENST00000316219.5_Silent_p.A68A			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	68	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCTCTTCCGGGCCCATGGGA	0.602000													33	189					5.43694e-19	8.90622e-19	0.023175	1	0
OR8H3	390152	broad.mit.edu	37	11	55890560	55890560	+	Missense_Mutation	SNP	T	T	A	rs143312423		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55890560T>A	ENST00000313472.3	+	1	712	c.712T>A	c.(712-714)Ttc>Atc	p.F238I		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					GCAGAAAGCTTTCTCTACTTG	0.403000													11	70					0	0	0.010729	0	0
TBC1D8	11138	broad.mit.edu	37	2	101706815	101706815	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:101706815C>G	ENST00000409318.1	-	2	269	c.139G>C	c.(139-141)Ggc>Cgc	p.G47R	TBC1D8_ENST00000376840.4_Missense_Mutation_p.G47R	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	47					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						TCCAGAGCGCCGACCAGGCGA	0.547000													7	45					0	0	0.003080	0	0
DCPS	28960	broad.mit.edu	37	11	126174154	126174154	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:126174154A>T	ENST00000263579.4	+	1	508	c.179A>T	c.(178-180)aAa>aTa	p.K60I	RP11-712L6.5_ENST00000524964.1_Missense_Mutation_p.L3M	NM_014026.3	NP_054745.1	Q96C86	DCPS_HUMAN	decapping enzyme, scavenger	60					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		GCGCGGGACAAAATCATTTTC	0.537000													19	99					0	0	0.012319	0	0
NEDD4L	23327	broad.mit.edu	37	18	55996235	55996235	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:55996235C>T	ENST00000456986.1	+	10	926	c.326C>T	c.(325-327)tCc>tTc	p.S109F	NEDD4L_ENST00000435432.2_Missense_Mutation_p.S109F|NEDD4L_ENST00000357895.5_Missense_Mutation_p.S222F|NEDD4L_ENST00000400345.3_Missense_Mutation_p.S230F|NEDD4L_ENST00000589054.1_Intron|NEDD4L_ENST00000586263.1_Missense_Mutation_p.S222F|NEDD4L_ENST00000256832.7_Missense_Mutation_p.S109F|NEDD4L_ENST00000431212.2_Missense_Mutation_p.S109F|NEDD4L_ENST00000456173.2_Missense_Mutation_p.S109F|NEDD4L_ENST00000356462.6_Missense_Mutation_p.S230F|NEDD4L_ENST00000382850.4_Missense_Mutation_p.S230F|NEDD4L_ENST00000256830.9_Missense_Mutation_p.S230F	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	230	C2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						AGGGACGTGTCCTCGGAGTCG	0.587000													5	65					0	0	0.014758	0	0
UPK1A	11045	broad.mit.edu	37	19	36159410	36159410	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:36159410C>T	ENST00000222275.2	+	2	139	c.139C>T	c.(139-141)Cgt>Tgt	p.R47C	UPK1A-AS1_ENST00000443196.1_RNA|UPK1A_ENST00000379013.2_Missense_Mutation_p.R47C	NM_007000.2	NP_008931.1	O00322	UPK1A_HUMAN	uroplakin 1A	47					epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity	p.R47S(1)		breast(1)|large_intestine(4)|lung(2)|stomach(2)	9	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGACCAGTACCGTGTATACCC	0.577000													8	96					0	0	0.006214	0	0
PSMA1	5682	broad.mit.edu	37	11	14526749	14526749	+	Missense_Mutation	SNP	T	T	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:14526749T>C	ENST00000530457.1	-	10	1236	c.706A>G	c.(706-708)Atg>Gtg	p.M236V	PSMA1_ENST00000555531.1_3'UTR|PSMA1_ENST00000396394.2_Missense_Mutation_p.M261V|PSMA1_ENST00000396393.1_Missense_Mutation_p.M261V|PSMA1_ENST00000419365.2_3'UTR|PSMA1_ENST00000524606.1_5'UTR|PSMA1_ENST00000418988.2_Missense_Mutation_p.M267V			P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	261					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						TAATGTTCCATTGGTTCATCA	0.333000													20	174					0	0	0.009535	0	0
TXNDC11	51061	broad.mit.edu	37	16	11785454	11785454	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:11785454G>A	ENST00000356957.3	-	9	1780	c.1673C>T	c.(1672-1674)aCt>aTt	p.T558I	TXNDC11_ENST00000283033.5_Missense_Mutation_p.T531I			Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	558					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						AAATGCAACAGTAGGGGCTTC	0.488000													4	133					0	0	0.014758	0	0
MYO15A	51168	broad.mit.edu	37	17	18023545	18023545	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:18023545C>A	ENST00000205890.5	+	2	1769	c.1431C>A	c.(1429-1431)ttC>ttA	p.F477L		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	477	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCCGCAAGTTCCGCCTCTTCC	0.647000													19	36					1.55795e-14	2.45841e-14	0.012319	1	0
NAA60	79903	broad.mit.edu	37	16	3533551	3533551	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:3533551A>G	ENST00000407558.4	+	6	829	c.526A>G	c.(526-528)Acc>Gcc	p.T176A	NAA60_ENST00000360862.5_Missense_Mutation_p.T111A|NAA60_ENST00000570819.1_Intron|NAA60_ENST00000572584.1_Missense_Mutation_p.T176A|NAA60_ENST00000577013.1_Intron|LA16c-306E5.3_ENST00000574423.2_RNA|NAA60_ENST00000576916.1_Intron|NAA60_ENST00000570551.1_3'UTR|NAA60_ENST00000424546.2_Missense_Mutation_p.T183A|LA16c-306E5.2_ENST00000575785.1_RNA|NAA60_ENST00000421765.3_Intron|NAA60_ENST00000414063.2_Missense_Mutation_p.T176A|NAA60_ENST00000573580.1_Missense_Mutation_p.T111A|NAA60_ENST00000572942.1_Intron|NAA60_ENST00000575076.1_Missense_Mutation_p.T176A	NM_001083601.1	NP_001077070.1	Q9H7X0	NAT15_HUMAN	N(alpha)-acetyltransferase 60, NatF catalytic subunit	176	N-acetyltransferase.						N-acetyltransferase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)	7						AGATGGCTTCACCTATGTCCT	0.488000													6	65					0	0	0.004482	0	0
TSHZ1	10194	broad.mit.edu	37	18	72997576	72997576	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:72997576G>T	ENST00000322038.5	+	2	663	c.79G>T	c.(79-81)Gcc>Tcc	p.A27S	TSHZ1_ENST00000580243.1_Missense_Mutation_p.A72S	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		TAACCAGGACGCCGGCTACGG	0.562000													4	28					0.00909568	0.0100933	0.009096	1	0
LRRC24	441381	broad.mit.edu	37	8	145749504	145749504	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:145749504C>T	ENST00000529415.2	-	4	714	c.597G>A	c.(595-597)ctG>ctA	p.L199L	LRRC14_ENST00000292524.1_3'UTR|LRRC24_ENST00000533758.1_Silent_p.L196L|LRRC14_ENST00000528528.1_Intron			Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24	199						integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGTGAGGCGCAGGACTTGCA	0.637000													65	190					0	0	0.014410	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85638600	85638600	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:85638600G>C	ENST00000393217.2	+	27	5111	c.5050G>C	c.(5050-5052)Gac>Cac	p.D1684H	LRRIQ1_ENST00000528777.3_3'UTR	NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1684										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CACGGATTTAGACCTTTTTTC	0.398000													15	79					0	0	0.010504	0	0
RCC1	1104	broad.mit.edu	37	1	28863368	28863368	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:28863368G>T	ENST00000373833.6	+	12	1332	c.1047G>T	c.(1045-1047)tcG>tcT	p.S349S	RCC1_ENST00000398958.2_Silent_p.S349S|RCC1_ENST00000373831.3_Silent_p.S380S|RCC1_ENST00000373832.1_Silent_p.S349S			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	349					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCTCCTCGGTGGCTTGTG	0.622000													39	226					4.65455e-14	7.21246e-14	0.014410	1	0
GPKOW	27238	broad.mit.edu	37	X	48978831	48978831	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:48978831C>A	ENST00000156109.5	-	3	451	c.373G>T	c.(373-375)Gac>Tac	p.D125Y		NM_015698.4	NP_056513.2	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	125						nucleus	nucleic acid binding			breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)	21						AGCGTGGGGTCGACACCCGCA	0.567000													5	31					3.59834e-05	4.35855e-05	0.021553	1	0
LZTS1	11178	broad.mit.edu	37	8	20107693	20107693	+	Missense_Mutation	SNP	C	C	A	rs148039718	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:20107693C>A	ENST00000381569.1	-	4	1688	c.1331G>T	c.(1330-1332)gGc>gTc	p.G444V	LZTS1_ENST00000522290.1_Missense_Mutation_p.G444V|LZTS1_ENST00000265801.6_Missense_Mutation_p.G444V			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	444					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		CAGCTCCAGGCCCTTGGTGCG	0.652000													21	112					7.41945e-09	1.03752e-08	0.027356	1	0
TAF6L	10629	broad.mit.edu	37	11	62554190	62554190	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:62554190C>T	ENST00000294168.3	+	11	1492	c.1291C>T	c.(1291-1293)Cct>Tct	p.P431S	RP11-727F15.12_ENST00000601484.1_RNA|TMEM223_ENST00000527073.1_Intron	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	431					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						GCCGGAGGACCCTTCTCTTTC	0.677000											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	33					0	0	0.001984	0	0
CTSL	1514	broad.mit.edu	37	9	90343602	90343602	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:90343602G>C	ENST00000343150.5	+	5	1389	c.499G>C	c.(499-501)Gta>Cta	p.V167L	CTSL_ENST00000340342.6_Missense_Mutation_p.V167L|CTSL_ENST00000495822.1_Intron|CTSL_ENST00000342020.5_Missense_Mutation_p.V167L					cathepsin L																		GCAGAATCTGGTAGACTGCTC	0.493000													5	115					0	0	0.014758	0	0
SETD3	84193	broad.mit.edu	37	14	99871602	99871602	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:99871602C>A	ENST00000331768.5	-	10	1190	c.1031G>T	c.(1030-1032)aGt>aTt	p.S344I		NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3	344					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GTCACTTTTACTCACTCCAAG	0.463000													26	85					7.33532e-06	9.34574e-06	0.021523	1	0
FRMPD4	9758	broad.mit.edu	37	X	12734352	12734352	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:12734352C>A	ENST00000380682.1	+	15	2280	c.1774C>A	c.(1774-1776)Cac>Aac	p.H592N		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	592					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TCCAAAAGAGCACCGGCACTT	0.507000													13	123					0.0285812	0.030534	0.028581	1	0
APOB	338	broad.mit.edu	37	2	21230012	21230012	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:21230012G>C	ENST00000233242.1	-	26	9855	c.9728C>G	c.(9727-9729)cCc>cGc	p.P3243R		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3243					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAAGGTCCTGGGGAGCTCGTC	0.378000													3	35					0	0	0.009096	0	0
PACSIN1	29993	broad.mit.edu	37	6	34499392	34499392	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:34499392C>G	ENST00000538621.1	+	9	1298	c.1053C>G	c.(1051-1053)gaC>gaG	p.D351E	PACSIN1_ENST00000374043.2_Missense_Mutation_p.D309E|PACSIN1_ENST00000244458.2_Missense_Mutation_p.D351E	NM_001199583.1	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	351					endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						GCAGCTACGACAGAGGCCAGC	0.622000													11	138					0	0	0.016723	0	0
ZNF250	58500	broad.mit.edu	37	8	146112249	146112249	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:146112249G>C	ENST00000292579.7	-	5	453	c.337C>G	c.(337-339)Caa>Gaa	p.Q113E	ZNF250_ENST00000342660.6_Missense_Mutation_p.Q108E|ZNF250_ENST00000417550.2_Missense_Mutation_p.Q108E|ZNF250_ENST00000543949.1_Missense_Mutation_p.Q113E	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		AAACTGTCTTGTTGTGTACAG	0.373000													16	138					0	0	0.010504	0	0
FCRL5	83416	broad.mit.edu	37	1	157514290	157514290	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:157514290G>A	ENST00000361835.3	-	5	763	c.606C>T	c.(604-606)atC>atT	p.I202I	FCRL5_ENST00000368189.3_Silent_p.I202I|FCRL5_ENST00000356953.4_Silent_p.I202I|FCRL5_ENST00000368191.3_Silent_p.I117I|FCRL5_ENST00000368190.3_Silent_p.I202I	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	202	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GGTTCCCGCTGATGGGCTGGA	0.562000													5	117					0	0	0.021553	0	0
SCN7A	6332	broad.mit.edu	37	2	167262236	167262236	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:167262236C>A	ENST00000409855.1	-	25	5029	c.4903G>T	c.(4903-4905)Gct>Tct	p.A1635S		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1635					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTTTTATAAGCACGTTGAATG	0.378000													15	109					1.3612e-06	1.78723e-06	0.024245	1	0
ANKS1B	56899	broad.mit.edu	37	12	100048885	100048885	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:100048885C>A	ENST00000547776.2	-	9	1231	c.1232G>T	c.(1231-1233)tGt>tTt	p.C411F	ANKS1B_ENST00000329257.7_Missense_Mutation_p.C411F|ANKS1B_ENST00000547010.1_5'UTR	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	411						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ACATCCATTACACGGAGTTAA	0.403000													9	45					7.03913e-09	9.92401e-09	0.013537	1	0
ORAI3	93129	broad.mit.edu	37	16	30964750	30964750	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:30964750G>C	ENST00000318663.4	+	2	697	c.473G>C	c.(472-474)gGc>gCc	p.G158A	ORAI3_ENST00000566237.1_Missense_Mutation_p.G158A|AC135048.13_ENST00000566056.1_RNA|ORAI3_ENST00000562699.1_Intron	NM_152288.2	NP_689501.1	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator 3	158						integral to membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6						ACTGCCCTGGGCACCTTTCTC	0.597000											OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	140					0	0	0.008361	0	0
OTOL1	131149	broad.mit.edu	37	3	161221658	161221658	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:161221658C>A	ENST00000327928.4	+	4	1362	c.1362C>A	c.(1360-1362)gtC>gtA	p.V454V		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	454	C1q.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						GGGTGTATGTCAGTGCTGAGG	0.438000													5	61					0.014758	0.016168	0.014758	1	0
DES	1674	broad.mit.edu	37	2	220286087	220286087	+	Missense_Mutation	SNP	G	G	T	rs57965306		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:220286087G>T	ENST00000373960.3	+	6	1135	c.1049G>T	c.(1048-1050)cGg>cTg	p.R350L		NM_001927.3	NP_001918.3	P17661	DESM_HUMAN	desmin	350	Coil 2B.|Rod.		R -> P (in Kaeser syndrome and MFM1; incapable of de novo formation of a desmin intermediate filaments network; exerts a dominant negative effect on the ordered lateral arrangement of desmin subunits; dbSNP:rs57965306).		cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)	18		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGGCAGATGCGGGAATTGGAG	0.587000													7	64					3.09899e-07	4.13198e-07	0.004482	1	0
DSG3	1830	broad.mit.edu	37	18	29056100	29056100	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:29056100G>A	ENST00000257189.4	+	16	2960	c.2877G>A	c.(2875-2877)gtG>gtA	p.V959V		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	959					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CACAAAATGTGATAGTGACAG	0.498000													4	154					0	0	0.009096	0	0
IGLV3-16	28799	broad.mit.edu	37	22	23090380	23090380	+	RNA	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr22:23090380C>T	ENST00000390311.2	+	0	357																											CTATTACTGTCTATCAGCAGA	0.517000													15	49					0	0	0.008871	0	0
CALCR	799	broad.mit.edu	37	7	93055880	93055880	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:93055880G>A	ENST00000359558.2	-	16	1614	c.1315C>T	c.(1315-1317)Caa>Taa	p.Q439*	CALCR_ENST00000421592.1_Nonsense_Mutation_p.Q421*|CALCR_ENST00000360249.4_Nonsense_Mutation_p.Q421*|CALCR_ENST00000426151.1_Nonsense_Mutation_p.Q405*|CALCR_ENST00000394441.1_Nonsense_Mutation_p.Q405*	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	421					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGGGCCCATTGGCGCTTCACG	0.532000													11	32					0	0	0.008291	0	0
PBX4	80714	broad.mit.edu	37	19	19681537	19681537	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:19681537C>A	ENST00000251203.8	-	3	585	c.299G>T	c.(298-300)gGa>gTa	p.G100V		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	100							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						TCCTCCTCTTCCTCTCTTCTC	0.602000													9	53					1.12685e-05	1.40448e-05	0.004482	1	0
FAM47A	158724	broad.mit.edu	37	X	34148985	34148985	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:34148985G>T	ENST00000346193.3	-	1	1462	c.1411C>A	c.(1411-1413)Ccc>Acc	p.P471T		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	471										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TGAGTCTCGGGAGGCTGCAGG	0.602000													11	68					2.27111e-07	3.07583e-07	0.013537	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106856830	106856830	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:106856830T>A	ENST00000526355.1	-	2	799	c.331A>T	c.(331-333)Agg>Tgg	p.R111W	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.R111W|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.R111W	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	111					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TGCAGTGTCCTCTTGAGAGTC	0.343000													15	75					0	0	0.028581	0	0
INPP5D	3635	broad.mit.edu	37	2	233995347	233995347	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:233995347G>A	ENST00000359570.5	+	5	654	c.654G>A	c.(652-654)aaG>aaA	p.K218K	INPP5D_ENST00000474278.1_3'UTR|INPP5D_ENST00000538935.1_Silent_p.K218K			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	218					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TGCTCTGCAAGGAGCTCTATG	0.577000													3	38					0	0	0.021553	0	0
RYR2	6262	broad.mit.edu	37	1	237813214	237813214	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:237813214A>T	ENST00000366574.2	+	50	7867	c.7550A>T	c.(7549-7551)aAt>aTt	p.N2517I	RYR2_ENST00000542537.1_Missense_Mutation_p.N2501I|RYR2_ENST00000360064.6_Missense_Mutation_p.N2515I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2517	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGGCCCTCAATCGGTACCTT	0.463000													28	132					0	0	0.019004	0	0
CYP4F3	4051	broad.mit.edu	37	19	15769110	15769110	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:15769110C>T	ENST00000221307.7	+	10	1200	c.1152C>T	c.(1150-1152)tgC>tgT	p.C384C	CYP4F3_ENST00000585846.1_Silent_p.C384C|CYP4F3_ENST00000591058.1_Silent_p.C384C|CYP4F3_ENST00000586182.1_Silent_p.C384C|CYP4F3_ENST00000592424.1_3'UTR	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	384					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.C384*(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TGACCATGTGCATTAAGGAGA	0.592000													17	122					0	0	0.006122	0	0
VAPA	9218	broad.mit.edu	37	18	9914270	9914270	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:9914270G>T	ENST00000400000.2	+	1	272	c.17G>T	c.(16-18)gGg>gTg	p.G6V	VAPA_ENST00000340541.4_Missense_Mutation_p.G6V	NM_003574.5|NM_194434.2	NP_003565.4|NP_919415.2	Q9P0L0	VAPA_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	6					cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						TCCGCCTCAGGGGCCATGGCG	0.721000													3	30					0.014758	0.016168	0.014758	1	0
BARX2	8538	broad.mit.edu	37	11	129246035	129246035	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:129246035C>A	ENST00000281437.4	+	1	201	c.105C>A	c.(103-105)acC>acA	p.T35T		NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	35										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CCAAGGAGACCTGCGATTACT	0.602000											OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	165					1.42033e-22	2.41878e-22	0.019004	1	0
FAT4	79633	broad.mit.edu	37	4	126372962	126372962	+	Silent	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:126372962A>T	ENST00000394329.3	+	9	10804	c.10791A>T	c.(10789-10791)acA>acT	p.T3597T	FAT4_ENST00000335110.5_Silent_p.T1895T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3597	Cadherin 34.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTCTTCCACAGGAACTGTGC	0.428000													20	106					0	0	0.021523	0	0
RYR1	6261	broad.mit.edu	37	19	39034259	39034259	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:39034259G>T	ENST00000355481.4	+	85	11982	c.11851G>T	c.(11851-11853)Gtg>Ttg	p.V3951L	RYR1_ENST00000360985.3_Missense_Mutation_p.V3951L|RYR1_ENST00000359596.3_Missense_Mutation_p.V3956L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3956					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCCATGTCGGTGGCTAAGCA	0.597000													17	105					5.3912e-06	6.92005e-06	0.006122	1	0
ASCC3	10973	broad.mit.edu	37	6	100965873	100965873	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:100965873A>G	ENST00000369162.2	-	38	6265	c.5921T>C	c.(5920-5922)cTt>cCt	p.L1974P		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTACTTGAAAAGGTGAAGATG	0.308000													3	79					0	0	0.004672	0	0
IL12A	3592	broad.mit.edu	37	3	159713204	159713204	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:159713204A>G	ENST00000305579.2	+	7	927	c.620A>G	c.(619-621)aAc>aGc	p.N207S	IL12A_ENST00000480787.1_Missense_Mutation_p.N169S|IL12A_ENST00000466512.1_Missense_Mutation_p.N193S|CTD-2049J23.2_ENST00000497452.1_RNA	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	173					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTGAATTTCAACAGTGAGACT	0.373000													8	74					0	0	0.004482	0	0
BEST2	54831	broad.mit.edu	37	19	12867072	12867072	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:12867072C>T	ENST00000549706.1	+	9	1390	c.1066C>T	c.(1066-1068)Cgg>Tgg	p.R356W	BEST2_ENST00000553030.1_Missense_Mutation_p.R356W|BEST2_ENST00000042931.1_Missense_Mutation_p.R356W			Q8NFU1	BEST2_HUMAN	bestrophin 2	356					membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	12						CTTCCAGCTGCGGCAGCCTTC	0.627000													10	199					0	0	0.010729	0	0
SSR4	6748	broad.mit.edu	37	X	153062934	153062934	+	Missense_Mutation	SNP	G	G	T	rs149873632		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:153062934G>T	ENST00000320857.3	+	4	1292	c.208G>T	c.(208-210)Gtc>Ttc	p.V70F	SSR4_ENST00000370085.3_Intron|SSR4_ENST00000460616.1_3'UTR|SSR4_ENST00000370087.1_Missense_Mutation_p.V70F|SSR4_ENST00000370086.3_Missense_Mutation_p.V70F	NM_001204526.1	NP_001191455.1	P51571	SSRD_HUMAN	signal sequence receptor, delta	70					intracellular protein transport	integral to membrane|Sec61 translocon complex	calcium ion binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(2)	4	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTATGCTGACGTCGGTGGAAA	0.617000													12	96					2.5808e-16	4.14857e-16	0.006122	1	0
ANKMY1	51281	broad.mit.edu	37	2	241465685	241465685	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:241465685C>A	ENST00000391987.1	-	6	1230	c.864G>T	c.(862-864)gtG>gtT	p.V288V	ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000272972.3_Silent_p.V288V|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000401804.1_Silent_p.V377V|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000405523.3_Intron			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	288							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTGCGTCCGCCACGTCAGCAC	0.552000													7	90					0.000274275	0.000314502	0.004482	1	0
MUC5B	727897	broad.mit.edu	37	11	1263477	1263477	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:1263477G>A	ENST00000447027.1	+	31	5434	c.5376G>A	c.(5374-5376)gaG>gaA	p.E1792E	MUC5B_ENST00000529681.1_Silent_p.E1789E			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1789	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGAAGTGTGAGTGGACAGAGT	0.587000													13	97					0	0	0.020292	0	0
MUC16	94025	broad.mit.edu	37	19	9087070	9087070	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:9087070G>T	ENST00000397910.4	-	1	4948	c.4745C>A	c.(4744-4746)tCc>tAc	p.S1582Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1582	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGGAAGGGGATGCTGAGGC	0.498000													23	209					2.27525e-19	3.76292e-19	0.021523	1	0
ZNF668	79759	broad.mit.edu	37	16	31073432	31073432	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:31073432T>A	ENST00000538906.1	-	3	1601	c.817A>T	c.(817-819)Acg>Tcg	p.T273S	ZNF668_ENST00000535577.1_Missense_Mutation_p.T273S|ZNF668_ENST00000300849.4_Missense_Mutation_p.T273S|ZNF668_ENST00000426488.2_Missense_Mutation_p.T296S|ZNF668_ENST00000417110.2_Missense_Mutation_p.V207E|ZNF668_ENST00000539836.3_Missense_Mutation_p.T296S|ZNF668_ENST00000394983.2_Missense_Mutation_p.T273S	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						CCCGAGTGCGTGCGCTCGTGG	0.692000													5	59					0	0	0.021553	0	0
EIF3C	8663	broad.mit.edu	37	16	28734627	28734627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:28734627G>T	ENST00000331666.6	+	9	1105	c.919G>T	c.(919-921)Gga>Tga	p.G307*	EIF3C_ENST00000566866.1_Nonsense_Mutation_p.G307*|EIF3C_ENST00000564243.1_Nonsense_Mutation_p.G297*|EIF3C_ENST00000395587.1_Nonsense_Mutation_p.G307*|EIF3C_ENST00000566501.1_Nonsense_Mutation_p.G307*			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	307						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity	p.G307*(2)		lung(5)|skin(1)	6						GGTCCGGGGCGGAGTGCCGTT	0.542000													39	534					1.38909e-20	2.3424e-20	0.014410	1	0
LINC00303	284573	broad.mit.edu	37	1	204009392	204009392	+	RNA	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:204009392C>A	ENST00000367207.3	-	0	304																											CATATCCACACCAGTGAGAGC	0.448000													5	18					0.00198382	0.00221569	0.001984	1	0
TRIM21	6737	broad.mit.edu	37	11	4409573	4409573	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:4409573T>A	ENST00000254436.7	-	4	804	c.692A>T	c.(691-693)gAg>gTg	p.E231V	TRIM21_ENST00000543625.1_Missense_Mutation_p.E231V	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	231			E -> K (in dbSNP:rs2554934).		cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		TCGATCTAGCTCTGAGATGAG	0.557000													10	67					0	0	0.010729	0	0
EPG5	57724	broad.mit.edu	37	18	43437840	43437840	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr18:43437840G>A	ENST00000282041.5	-	42	7454	c.7420C>T	c.(7420-7422)Cgg>Tgg	p.R2474W	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2474					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						GGCGACTTCCGGCCAAACCCA	0.488000													13	63					0	0	0.028581	0	0
SUPT16H	11198	broad.mit.edu	37	14	21836475	21836475	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:21836475T>G	ENST00000216297.2	-	7	1246	c.908A>C	c.(907-909)aAc>aCc	p.N303T		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	303					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GAGCAAAAAGTTATAATTTTC	0.408000													10	67					0	0	0.010729	0	0
HTR3B	9177	broad.mit.edu	37	11	113803729	113803729	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:113803729G>A	ENST00000260191.2	+	6	867	c.610G>A	c.(610-612)Gac>Aac	p.D204N	HTR3B_ENST00000537778.1_Missense_Mutation_p.D193N	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	204					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GTTTTTGAATGACAGTGAGTG	0.453000													6	42					0	0	0.021553	0	0
ADSS	159	broad.mit.edu	37	1	244580948	244580948	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:244580948A>G	ENST00000366535.3	-	10	1368	c.1052T>C	c.(1051-1053)aTg>aCg	p.M351T		NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	351					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	TCCATTGATCATATGAGCATA	0.363000													9	65					0	0	0.010729	0	0
LPHN3	23284	broad.mit.edu	37	4	62800699	62800699	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:62800699C>G	ENST00000512091.1	+	13	2797	c.2050C>G	c.(2050-2052)Ctt>Gtt	p.L684V	LPHN3_ENST00000514157.1_Missense_Mutation_p.L684V|LPHN3_ENST00000508693.1_Missense_Mutation_p.L752V|LPHN3_ENST00000507625.1_Missense_Mutation_p.L752V|LPHN3_ENST00000504896.1_Missense_Mutation_p.L684V|LPHN3_ENST00000508946.1_Missense_Mutation_p.L684V|LPHN3_ENST00000509896.1_Missense_Mutation_p.L752V|LPHN3_ENST00000508078.1_3'UTR|LPHN3_ENST00000506720.1_Missense_Mutation_p.L752V|LPHN3_ENST00000507164.1_Missense_Mutation_p.L752V|LPHN3_ENST00000506746.1_Missense_Mutation_p.L752V|LPHN3_ENST00000514591.1_Missense_Mutation_p.L684V|LPHN3_ENST00000506700.1_Missense_Mutation_p.L684V|LPHN3_ENST00000511324.1_Missense_Mutation_p.L752V|LPHN3_ENST00000545650.1_Missense_Mutation_p.L684V|LPHN3_ENST00000514996.1_Missense_Mutation_p.L684V			Q9HAR2	LPHN3_HUMAN	latrophilin 3	671					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GGCTGATAACCTTTTGAAGAC	0.443000													5	60					0	0	0.021553	0	0
SLC9A3	6550	broad.mit.edu	37	5	491958	491958	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:491958G>A	ENST00000264938.3	-	2	449	c.440C>T	c.(439-441)gCc>gTc	p.A147V	SLC9A3_ENST00000514375.1_Missense_Mutation_p.A147V	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	147						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACCCACGACGGCGTACAACAG	0.642000													6	15					0	0	0.021553	0	0
LRP1	4035	broad.mit.edu	37	12	57587439	57587439	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:57587439G>T	ENST00000243077.3	+	47	8241	c.7775G>T	c.(7774-7776)gGg>gTg	p.G2592V		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2592	LDL-receptor class A 12.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGACTGTGGGGATGGCTCT	0.602000													25	78					2.61193e-14	4.08411e-14	0.009535	1	0
TNR	7143	broad.mit.edu	37	1	175335167	175335167	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:175335167T>G	ENST00000367674.1	-	11	2869	c.2161A>C	c.(2161-2163)Acc>Ccc	p.T721P	TNR_ENST00000263525.2_Missense_Mutation_p.T721P	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	721	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GAGGATGGGGTAAAGGTAATT	0.552000													7	95					0	0	0.004482	0	0
TRPM1	4308	broad.mit.edu	37	15	31294305	31294305	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:31294305A>T	ENST00000542188.1	-	27	4962	c.4649T>A	c.(4648-4650)gTc>gAc	p.V1550D	TRPM1_ENST00000256552.6_Missense_Mutation_p.V1533D|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000397795.2_Missense_Mutation_p.V1511D	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1511					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TGCTTCAGCGACATGGTGTTC	0.458000													12	311					0	0	0.016723	0	0
SLC6A8	6535	broad.mit.edu	37	X	152960251	152960251	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:152960251G>T	ENST00000253122.5	+	12	2150	c.1674G>T	c.(1672-1674)gaG>gaT	p.E558D	SLC6A8_ENST00000430077.2_Missense_Mutation_p.E443D|SLC6A8_ENST00000485324.1_3'UTR	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	558					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GGTGGGGTGAGGCCATGGGCT	0.617000													11	62					1.61879e-10	2.37976e-10	0.013537	1	0
PTPRK	5796	broad.mit.edu	37	6	128643394	128643394	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:128643394C>A	ENST00000368227.3	-	3	651	c.285G>T	c.(283-285)ctG>ctT	p.L95L	PTPRK_ENST00000368215.3_Silent_p.L95L|PTPRK_ENST00000532331.1_Silent_p.L95L|PTPRK_ENST00000525459.1_Silent_p.L95L|PTPRK_ENST00000368213.5_Silent_p.L95L|PTPRK_ENST00000368207.3_Silent_p.L95L|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368226.4_Silent_p.L95L|PTPRK_ENST00000368210.3_Silent_p.L95L			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	95	MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCATTGTAGGCAGCTGAAGTC	0.388000													11	128					4.36969e-10	6.36938e-10	0.016723	1	0
HIPK2	28996	broad.mit.edu	37	7	139416071	139416071	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:139416071C>A	ENST00000406875.3	-	2	857	c.763G>T	c.(763-765)Gcc>Tcc	p.A255S	HIPK2_ENST00000342645.6_Missense_Mutation_p.A255S|HIPK2_ENST00000428878.2_Missense_Mutation_p.A255S	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	255	Interaction with DAXX.|Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					TAGTCATCGGCACTCTCCGTG	0.517000													9	38					1.12685e-05	1.40448e-05	0.004482	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	33					0.000602214	0.000685966	0.014758	1	0
FAM47B	170062	broad.mit.edu	37	X	34961812	34961812	+	Silent	SNP	C	C	G	rs142684131		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:34961812C>G	ENST00000329357.5	+	1	900	c.864C>G	c.(862-864)ccC>ccG	p.P288P		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	288	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CGGAGCCTCCCGAGACTCGCG	0.627000													10	71					0	0	0.010729	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764800	109764800	+	RNA	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:109764800G>T	ENST00000602699.1	+	0	1261					NR_002718.2																						TTTCTACCCGGCTGTGATGGC	0.562000													11	73					1.08611e-07	1.48262e-07	0.010729	1	0
SIX6	4990	broad.mit.edu	37	14	60976318	60976318	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr14:60976318C>A	ENST00000327720.5	+	1	650	c.202C>A	c.(202-204)Cgc>Agc	p.R68S		NM_007374.2	NP_031400.2	O95475	SIX6_HUMAN	SIX homeobox 6	68					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R68S(1)		NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)	11				OV - Ovarian serous cystadenocarcinoma(108;0.088)		TGGCAACTACCGCGAGCTCTA	0.607000													6	22					3.59834e-05	4.35855e-05	0.021553	1	0
GPA33	10223	broad.mit.edu	37	1	167032927	167032927	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:167032927C>A	ENST00000367868.3	-	4	806	c.463G>T	c.(463-465)Ggg>Tgg	p.G155W	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	155	Ig-like C2-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						ATGTTGTTCCCAATTATGGTC	0.547000													21	145					6.32553e-13	9.54378e-13	0.024334	1	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374412	95374412	+	RNA	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:95374412G>T	ENST00000494840.1	-	0	1449					NR_077228.1																						ATCCTTGTCTGGAGAAAAAGC	0.428000													14	71					1.05317e-09	1.50954e-09	0.020292	1	0
SLC25A38	54977	broad.mit.edu	37	3	39432934	39432934	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:39432934C>T	ENST00000273158.4	+	4	656	c.279C>T	c.(277-279)tcC>tcT	p.S93S		NM_017875.2	NP_060345.2	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	93					erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTCTGCAGTCCATTGTGAGAT	0.468000													79	543					0	0	0.014410	0	0
PPT2-EGFL8	100532746	broad.mit.edu	37	6	32122466	32122466	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:32122466A>G	ENST00000422437.1	+	2	286	c.95A>G	c.(94-96)cAc>cGc	p.H32R	PPT2_ENST00000324816.6_Missense_Mutation_p.H32R|PPT2_ENST00000375143.2_Missense_Mutation_p.H32R|PPT2-EGFL8_ENST00000453656.2_3'UTR|PPT2_ENST00000395523.1_Missense_Mutation_p.H32R|PPT2_ENST00000493548.1_3'UTR|PPT2_ENST00000375137.2_Missense_Mutation_p.H32R|PPT2_ENST00000437001.2_5'UTR|PPT2_ENST00000445576.2_Missense_Mutation_p.H32R|PPT2_ENST00000361568.2_Missense_Mutation_p.H38R																							CCCGCGCCCCACCGCGCGTCC	0.672000													7	66					0	0	0.001984	0	0
OR51V1	283111	broad.mit.edu	37	11	5221240	5221240	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:5221240G>A	ENST00000321255.1	-	1	690	c.691C>T	c.(691-693)Ctt>Ttt	p.L231F		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGACTTAAGAATCAGGATG	0.433000													8	53					0	0	0.003080	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948601	2948601	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:2948601G>A	ENST00000380520.1	-	6	3056	c.1062C>T	c.(1060-1062)ccC>ccT	p.P354P	SERPINB6_ENST00000380539.1_Silent_p.P354P|SERPINB6_ENST00000335686.5_Silent_p.P354P|SERPINB6_ENST00000380529.1_Silent_p.P354P|SERPINB6_ENST00000380546.3_Silent_p.P354P|SERPINB6_ENST00000380524.1_Silent_p.P354P			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	354					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGAAAAGGAAGGGGTGGTCGG	0.602000													3	38					0	0	0.004672	0	0
BICD1	636	broad.mit.edu	37	12	32458919	32458919	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr12:32458919C>T	ENST00000548411.1	+	4	1049	c.868C>T	c.(868-870)Cat>Tat	p.H290Y	BICD1_ENST00000281474.5_Missense_Mutation_p.H290Y	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	290					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CGGTCATATCCATGGGCCTCT	0.448000													5	51					0	0	0.021553	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926638	22926638	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:22926638C>A	ENST00000261374.3	+	2	1293	c.859C>A	c.(859-861)Cga>Aga	p.R287R		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	287						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		CGAGATGGGGCGAGTCCAGGA	0.532000													28	218					1.08312e-15	1.72497e-15	0.009535	1	0
KIAA1210	57481	broad.mit.edu	37	X	118238956	118238956	+	Splice_Site	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:118238956T>G	ENST00000402510.2	-	7	1066	c.1068_splice	c.e7+1	p.Q356_splice		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	356										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TATACTCACCTGAGTCGCTGT	0.428000													29	184					0	0	0.025465	0	0
MPRIP	23164	broad.mit.edu	37	17	17057722	17057722	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:17057722G>T	ENST00000395811.5	+	13	1557	c.1468G>T	c.(1468-1470)Gtg>Ttg	p.V490L	MPRIP_ENST00000444976.1_Missense_Mutation_p.V452L|MPRIP_ENST00000341712.4_Missense_Mutation_p.V490L|MPRIP_ENST00000395804.3_Missense_Mutation_p.V490L	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	490						cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						TGCCCCGGATGTGACCAGGTA	0.592000													12	60					6.31663e-08	8.69168e-08	0.024245	1	0
HYDIN	54768	broad.mit.edu	37	16	70889125	70889125	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:70889125C>G	ENST00000393567.2	-	73	12499	c.12349G>C	c.(12349-12351)Gat>Cat	p.D4117H		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4117										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AAGGAAAAATCGAACCCCTGC	0.547000													3	110					0	0	0.014758	0	0
TTC3	7267	broad.mit.edu	37	21	38459593	38459593	+	Silent	SNP	G	G	T	rs73201925	by1000genomes	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr21:38459593G>T	ENST00000399017.2	+	2	2783	c.36G>T	c.(34-36)gcG>gcT	p.A12A	TTC3_ENST00000540756.1_Intron|TTC3_ENST00000355666.1_Silent_p.A12A|TTC3_ENST00000354749.2_Silent_p.A12A|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000399010.1_Silent_p.A12A	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	12					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TCACTGTGGCGGATTATGCCT	0.403000													40	232					1.31962e-36	2.26974e-36	0.008740	1	0
IL16	3603	broad.mit.edu	37	15	81593853	81593853	+	Splice_Site	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr15:81593853G>T	ENST00000394660.2	+	15	3678	c.3318_splice	c.e15+1	p.K1106_splice	IL16_ENST00000302987.4_Splice_Site_p.K1106_splice|IL16_ENST00000394652.2_Splice_Site_p.K405_splice	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	1106	Interaction with HTLV-1 tax.|Interaction with PPP1R12A, PPP1R12B and PPP1R12C.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						CAACATTAAAGGTAGGTTTCC	0.473000													9	52					3.07112e-06	3.97167e-06	0.010729	1	0
OR8J3	81168	broad.mit.edu	37	11	55904714	55904714	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55904714G>T	ENST00000301529.1	-	1	480	c.481C>A	c.(481-483)Cct>Act	p.P161T		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AATATACAAGGTGAAACCACA	0.423000													13	74					0.00010058	0.000119309	0.013537	1	0
OR4C15	81309	broad.mit.edu	37	11	55321821	55321821	+	Silent	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:55321821A>T	ENST00000314644.2	+	1	39	c.39A>T	c.(37-39)gcA>gcT	p.A13A		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						ATAATTTTGCACTTGGATGTA	0.323000										HNSCC(20;0.049)			16	84					0	0	0.006122	0	0
FLI1	2313	broad.mit.edu	37	11	128680399	128680399	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:128680399C>T	ENST00000344954.6	+	9	1164	c.776C>T	c.(775-777)tCc>tTc	p.S259F	FLI1_ENST00000429175.2_Missense_Mutation_p.S292F|FLI1_ENST00000281428.8_Missense_Mutation_p.S226F|FLI1_ENST00000534087.1_Missense_Mutation_p.S259F|FLI1_ENST00000525560.1_Missense_Mutation_p.S99F			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	292					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GAGCTGCTCTCCGACAGCGCC	0.627000			T	EWSR1	Ewing sarcoma								5	11					0	0	0.014758	0	0
C19orf44	84167	broad.mit.edu	37	19	16612013	16612013	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:16612013G>T	ENST00000221671.3	+	2	566	c.410G>T	c.(409-411)gGg>gTg	p.G137V	CTD-3222D19.2_ENST00000409035.1_Intron|C19orf44_ENST00000594035.1_Missense_Mutation_p.G137V	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	137										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						ATCCTCTCTGGGGGTGCACTC	0.507000													12	60					1.05317e-09	1.50954e-09	0.020292	1	0
ERN2	10595	broad.mit.edu	37	16	23702633	23702633	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:23702633C>T	ENST00000256797.4	-	20	2802	c.2634G>A	c.(2632-2634)ccG>ccA	p.P878P	ERN2_ENST00000457008.2_Silent_p.P778P	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	830	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGTCTGCAGCGGCATGGAGA	0.672000													3	51					0	0	0.009096	0	0
GOLGB1	2804	broad.mit.edu	37	3	121383793	121383793	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:121383793T>G	ENST00000393667.3	-	21	9765	c.9655A>C	c.(9655-9657)Aca>Cca	p.T3219P	GOLGB1_ENST00000340645.5_Missense_Mutation_p.T3209P	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	3209					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CTGTTGCTTGTAAGATCTATT	0.478000													8	66					0	0	0.006214	0	0
FAM71B	153745	broad.mit.edu	37	5	156589684	156589684	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:156589684G>T	ENST00000302938.4	-	2	1687	c.1592C>A	c.(1591-1593)gCc>gAc	p.A531D		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	531						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATCTTACTGGCTTTCTTTTG	0.473000													13	44					1.5842e-08	2.19744e-08	0.016723	1	0
PIPSL	266971	broad.mit.edu	37	10	95720433	95720433	+	RNA	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:95720433G>T	ENST00000480546.1	-	0	864					NR_002319.2																						TCCAAAAAAAGACCATCAGGG	0.488000													9	46					1.58986e-06	2.07164e-06	0.008291	1	0
MUS81	80198	broad.mit.edu	37	11	65631311	65631311	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:65631311A>T	ENST00000308110.4	+	10	1347	c.998A>T	c.(997-999)gAg>gTg	p.E333V	MUS81_ENST00000533035.1_Missense_Mutation_p.E258V	NM_025128.4	NP_079404.3	Q96NY9	MUS81_HUMAN	MUS81 structure-specific endonuclease subunit	333	ERCC4.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	13				READ - Rectum adenocarcinoma(159;0.166)		CACATTGTGGAGCGCAAGCGA	0.607000								Homologous recombination					24	92					0	0	0.009535	0	0
AIM1	202	broad.mit.edu	37	6	106967686	106967686	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:106967686C>T	ENST00000369066.3	+	2	1866	c.1379C>T	c.(1378-1380)tCa>tTa	p.S460L		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	460							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CCTGCTGAGTCATCTCCTGGG	0.512000													9	108					0	0	0.010729	0	0
ZNF534	147658	broad.mit.edu	37	19	52941209	52941209	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:52941209G>T	ENST00000332323.6	+	4	596	c.535G>T	c.(535-537)Gat>Tat	p.D179Y	ZNF534_ENST00000433050.1_Missense_Mutation_p.D166Y|ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CTACAGAAATGATTTTCTTTT	0.333000													7	52					1.12685e-05	1.40448e-05	0.004482	1	0
ANKMY1	51281	broad.mit.edu	37	2	241465684	241465684	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:241465684C>A	ENST00000391987.1	-	6	1231	c.865G>T	c.(865-867)Gcg>Tcg	p.A289S	ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.A289S|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000401804.1_Missense_Mutation_p.A378S|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000405523.3_Intron			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	289							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTTGCGTCCGCCACGTCAGCA	0.552000													7	90					0.000274275	0.000314502	0.004482	1	0
ANKRD13B	124930	broad.mit.edu	37	17	27939023	27939023	+	Splice_Site	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:27939023A>G	ENST00000394859.3	+	10	1253	c.1100_splice	c.e10+1	p.K367_splice	RP11-68I3.2_ENST00000581474.1_RNA	NM_152345.4	NP_689558.4	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	367										cervix(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	16						CAAGACACAGAAGTGAGGCCC	0.612000													7	45					0	0	0.004482	0	0
ZNF98	148198	broad.mit.edu	37	19	22585642	22585642	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:22585642C>A	ENST00000357774.5	-	3	323	c.202G>T	c.(202-204)Gga>Tga	p.G68*	ZNF98_ENST00000601553.1_Nonsense_Mutation_p.G68*	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGTTCTTTTCCTTGCTCCAGA	0.423000													18	99					3.32936e-07	4.405e-07	0.006122	1	0
ISPD	729920	broad.mit.edu	37	7	16348241	16348241	+	Silent	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:16348241A>G	ENST00000407010.2	-	4	695	c.696T>C	c.(694-696)taT>taC	p.Y232Y	ISPD_ENST00000399310.3_Silent_p.Y182Y	NM_001101426.3	NP_001094896.1	A4D126	ISPD_HUMAN	isoprenoid synthase domain containing	232					isoprenoid biosynthetic process		nucleotidyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9						ATTCCAAGTCATAGTCACTAC	0.373000										Multiple Myeloma(15;0.18)			4	15					0	0	0.009096	0	0
CDH8	1006	broad.mit.edu	37	16	61689518	61689518	+	Missense_Mutation	SNP	T	T	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:61689518T>A	ENST00000577390.1	-	11	2716	c.1762A>T	c.(1762-1764)Agc>Tgc	p.S588C	CDH8_ENST00000299345.6_Missense_Mutation_p.S588C|CDH8_ENST00000577730.1_Missense_Mutation_p.S588C	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	588	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTGCTAGTGCTGCTCAGTGGA	0.453000													14	77					0	0	0.006122	0	0
CACNG8	59283	broad.mit.edu	37	19	54483188	54483188	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:54483188C>A	ENST00000270458.2	+	3	538	c.435C>A	c.(433-435)tgC>tgA	p.C145*		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	145					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GGGGTGTGTGCGTGGCGGCCT	0.642000													11	28					0.00010058	0.000119309	0.013537	1	0
SHCBP1	79801	broad.mit.edu	37	16	46649880	46649880	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:46649880C>A	ENST00000303383.3	-	4	840	c.574G>T	c.(574-576)Gcc>Tcc	p.A192S		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	192										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				ATTGCAAGGGCTGTCTGGTCA	0.463000													27	180					8.4185e-14	1.29284e-13	0.012213	1	0
ASTN2	23245	broad.mit.edu	37	9	119567928	119567928	+	Silent	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:119567928G>T	ENST00000313400.4	-	13	2479	c.2379C>A	c.(2377-2379)gtC>gtA	p.V793V	ASTN2_ENST00000373996.3_Silent_p.V789V|ASTN2_ENST00000361209.2_Silent_p.V742V|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	793						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCATCTGGAAGACTTGGCCTT	0.488000													20	114					3.73988e-18	6.06849e-18	0.006320	1	0
GPR27	2850	broad.mit.edu	37	3	71804119	71804119	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:71804119C>T	ENST00000304411.2	+	1	919	c.919C>T	c.(919-921)Cgg>Tgg	p.R307W		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	307						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CAGCTACCTGCGGGTCCTGGT	0.662000													5	44					0	0	0.014758	0	0
LRP1B	53353	broad.mit.edu	37	2	141299476	141299476	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:141299476C>T	ENST00000389484.3	-	44	8230	c.7259G>A	c.(7258-7260)tGg>tAg	p.W2420*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2420					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAGTCCGACCAGAATATATA	0.388000										TSP Lung(27;0.18)			13	62					0	0	0.020292	0	0
FAM65A	79567	broad.mit.edu	37	16	67579635	67579635	+	Missense_Mutation	SNP	G	G	A	rs139937481		TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:67579635G>A	ENST00000540839.3	+	20	3536	c.3316G>A	c.(3316-3318)Gag>Aag	p.E1106K	FAM65A_ENST00000428437.2_Missense_Mutation_p.E1101K|FAM65A_ENST00000042381.4_Missense_Mutation_p.E1087K|FAM65A_ENST00000422602.2_Missense_Mutation_p.E1107K|FAM65A_ENST00000379312.3_Missense_Mutation_p.E1091K			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	1091						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		ATTGGCGCCCGAGGGGCGTCT	0.622000													8	95					0	0	0.003080	0	0
ATOH8	84913	broad.mit.edu	37	2	85981354	85981354	+	Silent	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:85981354C>T	ENST00000306279.3	+	1	338	c.42C>T	c.(40-42)acC>acT	p.T14T		NM_032827.6	NP_116216.2	Q96SQ7	ATOH8_HUMAN	atonal homolog 8 (Drosophila)	14					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CGTGGAAGACCGTGTGCGTGA	0.692000													4	16					0	0	0.021553	0	0
RPL36A	6173	broad.mit.edu	37	X	100646034	100646034	+	Splice_Site	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:100646034G>A	ENST00000427805.2	+	1	223	c.111_splice	c.e1+1	p.M37_splice	RPL36A_ENST00000553110.3_Splice_Site_p.M1_splice|RPL36A-HNRNPH2_ENST00000409170.3_Splice_Site_p.W12_splice	NM_021029.5	NP_066357.2			ribosomal protein L36a											liver(4)|lung(1)|prostate(1)	6						ACGCAAGCATGGTAGGACTTG	0.582000											OREG0019892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	112					0	0	0.013537	0	0
PLB1	151056	broad.mit.edu	37	2	28840597	28840597	+	Missense_Mutation	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:28840597T>G	ENST00000422425.2	+	44	3210	c.3166T>G	c.(3166-3168)Tgg>Ggg	p.W1056G	PLB1_ENST00000541605.1_Missense_Mutation_p.W32G|PLB1_ENST00000327757.5_Missense_Mutation_p.W1067G	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1067	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GATTTAGAACTGGGGCAGTGA	0.463000													25	99					0	0	0.012213	0	0
AFF2	2334	broad.mit.edu	37	X	148037640	148037640	+	Missense_Mutation	SNP	C	C	A	rs140525796	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:148037640C>A	ENST00000370460.2	+	11	2544	c.2065C>A	c.(2065-2067)Cct>Act	p.P689T	AFF2_ENST00000370457.5_Missense_Mutation_p.P656T|AFF2_ENST00000342251.3_Missense_Mutation_p.P656T|AFF2_ENST00000286437.5_Missense_Mutation_p.P330T	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	689					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTAACATCCCTTTGGCTCC	0.488000													15	101					8.60227e-14	1.30937e-13	0.028581	1	0
PTPN5	84867	broad.mit.edu	37	11	18755170	18755170	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:18755170C>G	ENST00000396170.1	-	10	2181	c.917G>C	c.(916-918)aGa>aCa	p.R306T	PTPN5_ENST00000396168.1_Missense_Mutation_p.R314T|PTPN5_ENST00000358540.2_Missense_Mutation_p.R338T|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000396167.2_Missense_Mutation_p.R306T|PTPN5_ENST00000477854.1_Missense_Mutation_p.R142T|PTPN5_ENST00000396171.4_Missense_Mutation_p.R338T	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	338	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						CAGACACACTCTGCTGTGAGG	0.572000													5	116					0	0	0.014758	0	0
CDH23	64072	broad.mit.edu	37	10	73406352	73406352	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:73406352G>T	ENST00000224721.6	+	13	1447	c.1442G>T	c.(1441-1443)gGg>gTg	p.G481V	CDH23_ENST00000299366.7_Missense_Mutation_p.G521V|CDH23_ENST00000461841.3_Missense_Mutation_p.G521V|CDH23_ENST00000398842.3_Missense_Mutation_p.G476V|CDH23_ENST00000398809.4_Missense_Mutation_p.G476V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	476	Cadherin 5.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTCACCGTGGGGACCTCTGTG	0.562000													24	167					1.99505e-19	3.33154e-19	0.012213	1	0
SP4	6671	broad.mit.edu	37	7	21469643	21469643	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:21469643C>T	ENST00000222584.3	+	3	1078	c.860C>T	c.(859-861)gCt>gTt	p.A287V		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	287					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GGCCAGCCTGCTGCTACTGCT	0.517000													6	87					0	0	0.001984	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799060	57799060	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr11:57799060G>A	ENST00000302622.3	+	1	659	c.636G>A	c.(634-636)ctG>ctA	p.L212L	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				CTGTGCTACTGGCCTCCTCTA	0.547000													16	73					0	0	0.006122	0	0
ITPR1	3708	broad.mit.edu	37	3	4558210	4558210	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr3:4558210G>T	ENST00000302640.8	+	3	385	c.35G>T	c.(34-36)gGa>gTa	p.G12V	ITPR1_ENST00000544951.1_Missense_Mutation_p.G12V|ITPR1_ENST00000443694.2_Missense_Mutation_p.G12V|ITPR1_ENST00000357086.4_Missense_Mutation_p.G12V|ITPR1_ENST00000354582.6_Missense_Mutation_p.G12V|ITPR1_ENST00000456211.2_Missense_Mutation_p.G12V|ITPR1_ENST00000423119.2_Missense_Mutation_p.G12V	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	12					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTACATATTGGAGACATTTGT	0.383000													10	117					2.80697e-09	3.99008e-09	0.010729	1	0
PSENEN	55851	broad.mit.edu	37	19	36237385	36237385	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:36237385C>G	ENST00000587708.2	+	3	810	c.127C>G	c.(127-129)Ctt>Gtt	p.L43V	PSENEN_ENST00000222266.2_Missense_Mutation_p.L43V|PSENEN_ENST00000591949.1_Missense_Mutation_p.L43V|AC002398.9_ENST00000591613.2_Missense_Mutation_p.L43V			Q9NZ42	PEN2_HUMAN	presenilin enhancer gamma secretase subunit	43					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	aspartic-type endopeptidase activity|protein binding			central_nervous_system(1)|kidney(1)|liver(1)|lung(2)|ovary(2)|prostate(1)	8	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAGGCCTTCCTTGTCCCAGC	0.527000													15	128					0	0	0.008871	0	0
CDC25C	995	broad.mit.edu	37	5	137622942	137622942	+	Silent	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:137622942C>A	ENST00000323760.6	-	11	1220	c.942G>T	c.(940-942)ctG>ctT	p.L314L	CDC25C_ENST00000348983.3_Silent_p.L241L|CDC25C_ENST00000415130.2_Silent_p.L241L|CDC25C_ENST00000513970.1_Silent_p.L314L|CDC25C_ENST00000514555.1_Silent_p.L284L|CDC25C_ENST00000357274.3_Silent_p.L271L|CDC25C_ENST00000356505.3_Silent_p.L284L	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	314					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTTCCCCGACAGTAAGGCAG	0.468000													7	78					5.68852e-11	8.43471e-11	0.004482	1	0
AFP	174	broad.mit.edu	37	4	74306346	74306346	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr4:74306346C>A	ENST00000395792.2	+	4	398	c.298C>A	c.(298-300)Cat>Aat	p.H100N	AFP_ENST00000226359.2_Missense_Mutation_p.H100N	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	100	Albumin 1.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGAACTTTGCCATGAGAAAGA	0.373000									Alpha-Fetoprotein, Hereditary Persistence of				5	58					0.00116845	0.00132219	0.021553	1	0
RELN	5649	broad.mit.edu	37	7	103202036	103202036	+	Missense_Mutation	SNP	C	C	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:103202036C>G	ENST00000424685.2	-	36	5631	c.5472G>C	c.(5470-5472)gaG>gaC	p.E1824D	RELN_ENST00000428762.1_Missense_Mutation_p.E1824D|RELN_ENST00000343529.5_Missense_Mutation_p.E1824D			P78509	RELN_HUMAN	reelin	1824					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GATTCCCCCTCTCTGCACCAT	0.418000													21	152					0	0	0.006320	0	0
XIST	7503	broad.mit.edu	37	X	73062976	73062976	+	RNA	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:73062976C>A	ENST00000429829.1	-	0	9612					NR_001564.2																						TGATAACTGCCATTGTGCCTA	0.463000													7	41					0.000274275	0.000314502	0.004482	1	0
DNASE2B	58511	broad.mit.edu	37	1	84867698	84867698	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:84867698G>A	ENST00000370665.3	+	2	273	c.240G>A	c.(238-240)atG>atA	p.M80I		NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	80					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		AGCAACTAATGAATGACACCA	0.373000													5	50					0	0	0.001984	0	0
STK10	6793	broad.mit.edu	37	5	171520788	171520788	+	Silent	SNP	T	T	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:171520788T>G	ENST00000176763.5	-	9	1525	c.1182A>C	c.(1180-1182)ccA>ccC	p.P394P		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	394							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGGCCACGACTGGGGGACTGG	0.632000													10	75					0	0	0.010729	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963690	148963690	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr7:148963690G>T	ENST00000434415.1	+	2	452	c.289G>T	c.(289-291)Gcc>Tcc	p.A97S		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	97					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GGGCAAGTGGGCCGTGCTGGG	0.627000													14	99					2.31682e-05	2.84638e-05	0.024245	1	0
CSMD2	114784	broad.mit.edu	37	1	34003151	34003151	+	Silent	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:34003151G>A	ENST00000373381.4	-	61	9866	c.9690C>T	c.(9688-9690)ttC>ttT	p.F3230F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3209	Sushi 26.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCTGTAGGAGAAGCCTCGGT	0.602000													4	65					0	0	0.009096	0	0
SH3YL1	26751	broad.mit.edu	37	2	233146	233146	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:233146G>C	ENST00000403657.1	-	9	2395	c.200C>G	c.(199-201)tCt>tGt	p.S67C	SH3YL1_ENST00000468321.1_5'UTR|SH3YL1_ENST00000415006.2_Missense_Mutation_p.S67C|SH3YL1_ENST00000405430.1_Missense_Mutation_p.S163C|SH3YL1_ENST00000403712.2_Missense_Mutation_p.S163C|SH3YL1_ENST00000403658.1_Missense_Mutation_p.S67C|SH3YL1_ENST00000356150.5_Missense_Mutation_p.S163C			Q96HL8	SH3Y1_HUMAN	SH3 and SYLF domain containing 1	163										large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	7	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		CCCTTCTAAAGACACGCCTGC	0.423000													6	38					0	0	0.006214	0	0
NES	10763	broad.mit.edu	37	1	156641024	156641024	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:156641024C>T	ENST00000368223.3	-	4	3088	c.2956G>A	c.(2956-2958)Gat>Aat	p.D986N		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	986	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGAAGCCATCCTGCTCCCTC	0.592000													11	525					0	0	0.028581	0	0
NALCN	259232	broad.mit.edu	37	13	101712256	101712256	+	Missense_Mutation	SNP	G	G	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr13:101712256G>A	ENST00000251127.6	-	42	4900	c.4819C>T	c.(4819-4821)Cgg>Tgg	p.R1607W		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1607						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTCAGAAACCGGCTCAGCTCT	0.532000													8	133					0	0	0.004482	0	0
RGN	9104	broad.mit.edu	37	X	46951083	46951083	+	Missense_Mutation	SNP	G	G	A	rs147490967	byFrequency	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:46951083G>A	ENST00000397180.1	+	6	1538	c.569G>A	c.(568-570)cGc>cAc	p.R190H	RGN_ENST00000352078.4_Missense_Mutation_p.R190H|RGN_ENST00000457380.1_Missense_Mutation_p.R118H|RGN_ENST00000336169.3_Missense_Mutation_p.R190H	NM_152869.2	NP_690608.1	Q15493	RGN_HUMAN	regucalcin	190					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	9						ATAGCCAACCGCAGAAGTGTT	0.428000													11	64					0	0	0.028581	0	0
PIK3R6	146850	broad.mit.edu	37	17	8731998	8731998	+	Missense_Mutation	SNP	G	G	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:8731998G>T	ENST00000311434.9	-	11	1438	c.1199C>A	c.(1198-1200)cCc>cAc	p.P400H	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	400					platelet activation	cytosol											ATCCCCACTGGGCCGGCCTGT	0.692000													5	20					0.0215528	0.0231692	0.021553	1	0
PLEC	5339	broad.mit.edu	37	8	144993590	144993590	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr8:144993590C>A	ENST00000322810.4	-	32	10979	c.10810G>T	c.(10810-10812)Gcc>Tcc	p.A3604S	PLEC_ENST00000354589.3_Missense_Mutation_p.A3467S|PLEC_ENST00000354958.2_Missense_Mutation_p.A3445S|PLEC_ENST00000436759.2_Missense_Mutation_p.A3494S|PLEC_ENST00000398774.2_Missense_Mutation_p.A3435S|PLEC_ENST00000345136.3_Missense_Mutation_p.A3467S|PLEC_ENST00000527096.1_Missense_Mutation_p.A3490S|PLEC_ENST00000357649.2_Missense_Mutation_p.A3471S|PLEC_ENST00000356346.3_Missense_Mutation_p.A3453S	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3604	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCGATCTGGGCCTCCAGCAGG	0.667000													9	60					3.09899e-07	4.13198e-07	0.004482	1	0
AP1B1	162	broad.mit.edu	37	22	29754807	29754807	+	Missense_Mutation	SNP	C	C	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr22:29754807C>A	ENST00000357586.2	-	5	619	c.433G>T	c.(433-435)Gtg>Ttg	p.V145L	AP1B1_ENST00000317368.7_Missense_Mutation_p.V145L|AP1B1_ENST00000405198.1_Missense_Mutation_p.V145L|AP1B1_ENST00000402502.1_Missense_Mutation_p.V145L|AP1B1_ENST00000356015.2_Missense_Mutation_p.V145L|AP1B1_ENST00000415447.1_Missense_Mutation_p.V145L|AP1B1_ENST00000432560.2_Missense_Mutation_p.V145L	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	145					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						AGCTTGGCCACGCACACAGCT	0.577000													7	48					2.17888e-05	2.69616e-05	0.006214	1	0
MDH1B	130752	broad.mit.edu	37	2	207621963	207621963	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:207621963G>C	ENST00000374412.3	-	3	543	c.268C>G	c.(268-270)Cag>Gag	p.Q90E	MDH1B_ENST00000392214.2_Missense_Mutation_p.Q90E|MDH1B_ENST00000449792.1_5'UTR|MDH1B_ENST00000454776.2_Missense_Mutation_p.Q90E	NM_001039845.1	NP_001034934.1	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	90					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(14)|ovary(4)|stomach(1)	34				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTATATACCTGAGCATGCTCC	0.368000													20	87					0	0	0.016522	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999372	27999372	+	Missense_Mutation	SNP	G	G	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chrX:27999372G>C	ENST00000441525.1	-	1	194	c.80C>G	c.(79-81)tCt>tGt	p.S27C		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	27										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TGCTACTCCAGACTGCTCCTC	0.567000													10	45					0	0	0.013537	0	0
CELF3	11189	broad.mit.edu	37	1	151681551	151681551	+	Missense_Mutation	SNP	A	A	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:151681551A>T	ENST00000290583.4	-	5	1202	c.409T>A	c.(409-411)Tgc>Agc	p.C137S	CELF3_ENST00000470688.1_5'UTR|CELF3_ENST00000290585.4_Missense_Mutation_p.C137S	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	137	RRM 2.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						ACGAAGGCGCAGCCTGGAGAG	0.667000													17	115					0	0	0.014323	0	0
SLC13A2	9058	broad.mit.edu	37	17	26822805	26822805	+	Missense_Mutation	SNP	A	A	G			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:26822805A>G	ENST00000444914.3	+	10	2008	c.1588A>G	c.(1588-1590)Acg>Gcg	p.T530A	SLC13A2_ENST00000537681.1_Missense_Mutation_p.T410A|SLC13A2_ENST00000545060.1_Missense_Mutation_p.T438A|SLC13A2_ENST00000314669.5_Missense_Mutation_p.T481A	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	481						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GGCCACCACTACGATCTTCCT	0.637000													29	185					0	0	0.021022	0	0
VNN2	8875	broad.mit.edu	37	6	133078815	133078815	+	Missense_Mutation	SNP	C	C	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr6:133078815C>T	ENST00000326499.6	-	1	332	c.208G>A	c.(208-210)Gag>Aag	p.E70K	VNN2_ENST00000526192.1_5'UTR|VNN2_ENST00000525289.1_Missense_Mutation_p.E70K|VNN2_ENST00000525270.1_Missense_Mutation_p.E17K	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	70	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		AATACCTGCTCAGCTGCCTGC	0.433000													4	78					0	0	0.009096	0	0
RSPO1	284654	broad.mit.edu	37	1	38078467	38078469	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:38078467_38078469delTGC	ENST00000356545.2	-	8	1537_1539	c.750_752delGCA	c.(748-753)caa>ca	p.QQ250del	RSPO1_ENST00000401070.1_In_Frame_Del_p.QQ187del|RSPO1_ENST00000373059.1_In_Frame_Del_p.QQ223del|RSPO1_ENST00000401068.1_In_Frame_Del_p.QQ250del|RSPO1_ENST00000401069.1_In_Frame_Del_p.QQ250del|RSPO1_ENST00000401071.2_In_Frame_Del_p.QQ187del	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	250					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACTGTCCCTTGCTGCTGCTGCT	0.621													7	243	---	---	---	---					
SLAMF6	114836	broad.mit.edu	37	1	160458940	160458940	+	Frame_Shift_Del	DEL	C	C	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr1:160458940delC	ENST00000368059.3	-	6	883	c.814delG	c.(814-816)agfs	p.E272fs	SLAMF6_ENST00000368057.3_Frame_Shift_Del_p.E273fs|SLAMF6_ENST00000368055.1_Frame_Shift_Del_p.E162fs	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	273						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			GAAACATACTCTAGGTTCCTT	0.473													19	167	---	---	---	---					
LOC728730	728730	broad.mit.edu	37	2	39791858	39791860	+	RNA	DEL	TGC	TGC	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr2:39791858_39791860delTGC	ENST00000449569.1	+	0	538				AC007246.3_ENST00000451547.1_RNA|AC007246.3_ENST00000446698.1_RNA|AC007246.3_ENST00000415640.1_RNA|AC007246.3_ENST00000438649.1_RNA|AC007246.3_ENST00000425775.1_RNA|AC007246.3_ENST00000426083.1_RNA|AC007246.3_ENST00000422128.1_RNA	NR_037875.1																						tatagaagggtgctgctgctgct	0.601													2	4	---	---	---	---					
RICTOR	253260	broad.mit.edu	37	5	38942422	38942423	+	Frame_Shift_Ins	INS	-	-	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:38942422_38942423insT	ENST00000357387.3	-	38	5140_5141	c.5110_5111insA	c.(5110-5112)atcfs	p.I1704fs	RICTOR_ENST00000296782.5_Frame_Shift_Ins_p.I1728fs	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1704					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TTCAGCAGATGTATCAACTATA	0.347													14	209	---	---	---	---					
C6	729	broad.mit.edu	37	5	41201800	41201801	+	Frame_Shift_Ins	INS	-	-	A			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr5:41201800_41201801insA	ENST00000263413.3	-	3	423_424	c.159_160insT	c.(157-162)gaagtafs	p.EV53fs	C6_ENST00000337836.5_Frame_Shift_Ins_p.EV53fs	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	53	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGGTAGTACTTATCTACTACTA	0.391													41	94	---	---	---	---					
MTAP	4507	broad.mit.edu	37	9	21816764	21816765	+	Frame_Shift_Ins	INS	-	-	T			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr9:21816764_21816765insT	ENST00000380172.4	+	3	378_379	c.172_173insT	c.(172-174)tgcfs	p.C58fs	RP11-145E5.5_ENST00000404796.2_Frame_Shift_Ins_p.C58fs|MTAP_ENST00000427788.2_3'UTR|MTAP_ENST00000580900.1_Frame_Shift_Ins_p.C58fs|MTAP_ENST00000460874.2_Frame_Shift_Ins_p.C75fs	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	58					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TTGCGTCCTCCTTGCAAGGTAT	0.322													57	218	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396277	+	RNA	DEL	G	G	-	rs148140777	by1000genomes	TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:118396277delG	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTT	0.423													3	5	---	---	---	---					
DHX32	55760	broad.mit.edu	37	10	127548457	127548461	+	Frame_Shift_Del	DEL	ATGAA	ATGAA	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr10:127548457_127548461delATGAA	ENST00000284690.3	-	3	1050_1054	c.560_564delTTCAT	c.(559-564)afs	p.IH187fs	DHX32_ENST00000284688.6_Frame_Shift_Del_p.IH187fs	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	187	Helicase ATP-binding.					mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGCTTCTTTCATGAATATCATCTAA	0.366													9	65	---	---	---	---					
HSF4	3299	broad.mit.edu	37	16	67201666	67201666	+	Frame_Shift_Del	DEL	G	G	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr16:67201666delG	ENST00000264009.8	+	11	1863	c.898delG	c.(898-900)ggfs	p.G301fs	HSF4_ENST00000584272.1_Intron|HSF4_ENST00000521374.1_Frame_Shift_Del_p.G301fs|HSF4_ENST00000421453.1_Intron	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4	301	Interactions with DUSP26, MAPK1 and MAPK2.				response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.D302fs*14(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGCCAGTCCAGGGGGGGATGG	0.647													2	4	---	---	---	---					
MSL1	339287	broad.mit.edu	37	17	38290535	38290535	+	Frame_Shift_Del	DEL	T	T	-			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr17:38290535delT	ENST00000398532.3	+	9	2073	c.1758delT	c.(1756-1758)aafs	p.N586fs	MSL1_ENST00000579565.1_Frame_Shift_Del_p.N323fs|MSL1_ENST00000578648.1_Frame_Shift_Del_p.N570fs			Q68DK7	MSL1_HUMAN	male-specific lethal 1 homolog (Drosophila)	586					histone H4-K16 acetylation	MSL complex				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	7						TTGCCAGGAATTTTGAGCTAC	0.463													2	4	---	---	---	---					
PRR12	57479	broad.mit.edu	37	19	50098807	50098808	+	Frame_Shift_Ins	INS	-	-	C			TCGA-93-7347-01A-11D-2184-08	TCGA-93-7347-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98ed5f8c-bc0b-47ac-aee7-456fda144cb2	4b1d71f3-ddc2-47c7-9b49-4c92b6cfb713	g.chr19:50098807_50098808insC	ENST00000418929.2	+	4	1227_1228	c.1215_1216insC	c.(1213-1218)agccccfs	p.SP405fs		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	145	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GTGCCACCAGGCCCCCCCCACC	0.688													2	4	---	---	---	---					
