Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PNMA2	10687	broad.mit.edu	37	8	26365954	26365954	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr8:26365954C>G	ENST00000522362.2	-	3	1212	c.318G>C	c.(316-318)ttG>ttC	p.L106F		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	106					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		gaaacaggttcaatctttcaa	0.547000													5	64					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231036849	231036849	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:231036849G>A	ENST00000258381.6	-	16	1825	c.1748C>T	c.(1747-1749)tCa>tTa	p.S583L	AC009950.2_ENST00000595586.1_RNA|AC009950.2_ENST00000454058.1_RNA|AC009950.2_ENST00000594622.1_RNA|SP110_ENST00000358662.4_Missense_Mutation_p.S583L|AC009950.2_ENST00000600787.1_RNA	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	583	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TTGGCTTCCTGAAGACCTCTT	0.532000													8	98					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47376203	47376203	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:47376203C>A	ENST00000232766.5	+	6	812	c.792C>A	c.(790-792)caC>caA	p.H264Q	KLHL18_ENST00000455924.2_Missense_Mutation_p.H152Q	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	264										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		AGGACTACCACCTCATGCCAG	0.567000													5	42					0.248553	0.251393	1	1	0
TMED6	146456	broad.mit.edu	37	16	69385535	69385535	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:69385535C>G	ENST00000288025.3	-	1	177	c.122G>C	c.(121-123)cGa>cCa	p.R41P	RP11-343C2.9_ENST00000563634.1_Intron|RP11-343C2.7_ENST00000564737.1_Silent_p.S33S	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	41					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						AAAGTCATATCGATCAGCTCC	0.522000													6	115					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135309	27135309	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:27135309G>A	ENST00000343060.4	-	1	284	c.223C>T	c.(223-225)Ccc>Tcc	p.P75S	HOXA1_ENST00000355633.5_Missense_Mutation_p.P75S|HOTAIRM1_ENST00000495032.1_RNA	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	75						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCCGGCtgggggtggcgatgg	0.637000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	71					0	0	1	0	0
TERF1	7013	broad.mit.edu	37	8	73958199	73958199	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr8:73958199T>C	ENST00000276602.6	+	9	1110	c.1087T>C	c.(1087-1089)Tgg>Cgg	p.W363R	TERF1_ENST00000276603.5_Missense_Mutation_p.W383R	NM_003218.3	NP_003209.2	P54274	TERF1_HUMAN	telomeric repeat binding factor (NIMA-interacting) 1	383	Interaction with RLIM.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9	Breast(64;0.218)		Epithelial(68;0.0984)			TCAAAAGGCATGGCTTTGGGA	0.313000													4	64					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56271143	56271143	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:56271143G>A	ENST00000225371.5	+	4	525	c.415G>A	c.(415-417)Gag>Aag	p.E139K		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	139					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding	p.E139K(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						GGACCAGGCCGAGCGCTGCAG	0.657000													3	26					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50241757	50241757	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr20:50241757C>G	ENST00000338821.5	-	18	2254	c.1990G>C	c.(1990-1992)Gag>Cag	p.E664Q	ATP9A_ENST00000402822.1_Missense_Mutation_p.E543Q|ATP9A_ENST00000311637.5_Missense_Mutation_p.E528Q	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	664					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CTCAGGGTCTCCAGCGTGGGC	0.632000													5	39					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91843965	91843965	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:91843965C>G	ENST00000370425.3	-	10	1329	c.1231G>C	c.(1231-1233)Gat>Cat	p.D411H	HFM1_ENST00000370424.3_Missense_Mutation_p.D90H|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	411	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		ATTACCTCATCAATGAGAAAC	0.343000													7	77					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235918941	235918941	+	Missense_Mutation	SNP	C	C	G	rs80338661		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:235918941C>G	ENST00000389794.3	-	25	7240	c.7066G>C	c.(7066-7068)Gat>Cat	p.D2356H	LYST_ENST00000389793.2_Missense_Mutation_p.D2356H			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2356					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAATATGCATCTAATAGCTAA	0.279000													20	76					0	0	1	0	0
DNAJC18	202052	broad.mit.edu	37	5	138761964	138761964	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:138761964G>A	ENST00000302060.5	-	4	536	c.456C>T	c.(454-456)ttC>ttT	p.F152F		NM_152686.3	NP_689899.1	Q9H819	DJC18_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 18	152					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GAGGGGCAGTGAAAGTCACCT	0.438000													5	73					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554207	85554207	+	Silent	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:85554207A>G	ENST00000377386.3	-	2	1110	c.648T>C	c.(646-648)acT>acC	p.T216T	TGOLN2_ENST00000409232.3_Silent_p.T216T|TGOLN2_ENST00000409015.1_Silent_p.T216T|TGOLN2_ENST00000398263.2_Silent_p.T216T|TGOLN2_ENST00000282120.2_Silent_p.T118T|TGOLN2_ENST00000444342.2_Silent_p.T216T			O43493	TGON2_HUMAN	trans-golgi network protein 2	216	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CGTCTTTTGGAGTCTGCTTCT	0.607000													19	294					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21902374	21902374	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:21902374C>T	ENST00000374840.3	+	10	1396	c.1146C>T	c.(1144-1146)gtC>gtT	p.V382V	ALPL_ENST00000425315.2_Silent_p.V382V|ALPL_ENST00000374830.1_Silent_p.V28V|ALPL_ENST00000539907.1_Silent_p.V305V|ALPL_ENST00000374829.1_Silent_p.V28V|ALPL_ENST00000374832.1_Silent_p.V382V|ALPL_ENST00000540617.1_Silent_p.V327V	NM_000478.4	NP_000469.3	P05186	PPBT_HUMAN	alkaline phosphatase, liver/bone/kidney	382			V -> I (in HOPS).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	26		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	ATTCCCACGTCTTCACATTTG	0.607000													6	129					0	0	1	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	T	C	rs112064181	by1000genomes	TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:29061941T>C	ENST00000582557.1	+	0	861																											TAGATTTCTTTGAACTCGGAA	0.303000													5	63					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150471498	150471498	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:150471498C>A	ENST00000369064.3	+	12	1561	c.1527C>A	c.(1525-1527)gaC>gaA	p.D509E	TARS2_ENST00000438568.2_3'UTR|TARS2_ENST00000606933.1_Missense_Mutation_p.D427E|TARS2_ENST00000369054.2_Missense_Mutation_p.D379E|TARS2_ENST00000463555.1_3'UTR	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	509					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GCCTTTGGGACCAGGCCGAAC	0.547000													6	98					0.0215528	0.022573	1	1	0
IGLV2-28	28812	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	11					0.004672	0.00492229	1	1	0
UNC79	57578	broad.mit.edu	37	14	94120089	94120089	+	Splice_Site	SNP	A	A	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr14:94120089A>C	ENST00000553484.1	+	38	6422	c.6266_splice	c.e38-1	p.M2090_splice	UNC79_ENST00000393151.2_Splice_Site_p.M2068_splice|UNC79_ENST00000256339.4_Splice_Site_p.M1891_splice|UNC79_ENST00000555664.1_Splice_Site_p.M2029_splice			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2068						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CAACTCCAGCATGATGGTTCC	0.547000													71	283					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110574254	110574254	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:110574254T>C	ENST00000338081.3	-	5	1238	c.1067A>G	c.(1066-1068)aAg>aGg	p.K356R	DCX_ENST00000371993.2_Missense_Mutation_p.K275R|DCX_ENST00000356220.3_Missense_Mutation_p.K275R|DCX_ENST00000496551.1_5'UTR|DCX_ENST00000488120.1_Missense_Mutation_p.K275R|DCX_ENST00000356915.2_Missense_Mutation_p.K275R	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	356					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						TGGGTTTCCCTTCATGACTCG	0.527000													8	50					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71650870	71650870	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:71650870C>G	ENST00000409544.1	+	22	4856	c.4226C>G	c.(4225-4227)tCa>tGa	p.S1409*	ZNF638_ENST00000264447.4_Nonsense_Mutation_p.S1409*|ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000409407.1_Nonsense_Mutation_p.S349*	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1409					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GCTACAGTTTCAAAAACTGAA	0.368000													6	57					0	0	1	0	0
C3orf35	339883	broad.mit.edu	37	3	37476507	37476507	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:37476507G>A	ENST00000328376.5	+	6	1378	c.399G>A	c.(397-399)ctG>ctA	p.L133L	C3orf35_ENST00000481400.1_3'UTR	NM_178339.2	NP_848029.2	Q8IVJ8	APRG1_HUMAN	chromosome 3 open reading frame 35	133						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	11						CAGCACACCTGGTGCGTGGGG	0.537000													3	30					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2231581	2231581	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:2231581C>T	ENST00000343516.6	-	18	1880	c.1788G>A	c.(1786-1788)atG>atA	p.M596I		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	596	SAM 2.				signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TCACAGCGAGCATCAGCTTCT	0.687000													3	8					0	0	1	0	0
IL3	3562	broad.mit.edu	37	5	131396515	131396515	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:131396515T>C	ENST00000296870.2	+	1	294	c.116T>C	c.(115-117)aTc>aCc	p.I39T		NM_000588.3	NP_000579.2	P08700	IL3_HUMAN	interleukin 3 (colony-stimulating factor, multiple)	39					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)	10		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	TCTAACATGATCGATGAAATT	0.537000													6	79					0	0	1	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	11					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35870031	35870031	+	Missense_Mutation	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:35870031T>G	ENST00000377981.2	-	1	430	c.368A>C	c.(367-369)tAc>tCc	p.Y123S		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GATGGCCAGGTAGCGGTCATA	0.617000													4	52					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30671931	30671931	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:30671931G>C	ENST00000376406.3	-	10	5676	c.5029C>G	c.(5029-5031)Cag>Gag	p.Q1677E	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Missense_Mutation_p.Q1413E	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1677					cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGACCACCCTGAGCTATGGCC	0.537000								Other conserved DNA damage response genes					9	111					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179312040	179312040	+	Silent	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:179312040A>G	ENST00000367619.3	+	9	1046	c.903A>G	c.(901-903)ttA>ttG	p.L301L	SOAT1_ENST00000540564.1_Silent_p.L243L|SOAT1_ENST00000535686.1_Silent_p.L37L|SOAT1_ENST00000539888.1_Silent_p.L236L	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	301					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	TGTACTTCTTATTTGCTCCTA	0.408000													16	94					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128890529	128890529	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:128890529C>T	ENST00000371106.3	+	14	1557	c.1365C>T	c.(1363-1365)taC>taT	p.Y455Y		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	455					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GGGGGCAGTACTGGTATGTAC	0.577000													6	24					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60689297	60689297	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:60689297C>G	ENST00000335712.6	-	4	977	c.750G>C	c.(748-750)gaG>gaC	p.E250D	BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000538214.1_Missense_Mutation_p.E216D|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.E216D|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.E250D	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	250					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GGCCGGAAGCCTCTCTCGATA	0.562000			T	IGH@	B-CLL								4	56					0	0	1	0	0
ZNF773	374928	broad.mit.edu	37	19	58017984	58017984	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:58017984C>T	ENST00000282292.4	+	4	661	c.521C>T	c.(520-522)tCa>tTa	p.S174L	ZNF773_ENST00000598770.1_Missense_Mutation_p.S173L|ZNF773_ENST00000593916.1_Intron|ZNF773_ENST00000599847.1_Intron	NM_198542.1	NP_940944.1	Q6PK81	ZN773_HUMAN	zinc finger protein 773	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		GGAGAGAAGTCACATAGGAGC	0.468000													4	41					0	0	1	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252142	26252142	+	Silent	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:26252142G>C	ENST00000356350.2	+	1	264	c.264G>C	c.(262-264)tcG>tcC	p.S88S		NM_003524.2	NP_003515.1	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	88					nucleosome assembly	nucleosome|nucleus	DNA binding	p.S88S(1)		NS(3)|breast(2)|large_intestine(1)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	17						ACAAGCGTTCGACCATCACCT	0.597000													17	122					0	0	1	0	0
C5orf55	116349	broad.mit.edu	37	5	442605	442605	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:442605C>T	ENST00000408966.2	-	1	653	c.333G>A	c.(331-333)ctG>ctA	p.L111L		NM_138464.2	NP_612473.1	Q8N2X6	CE055_HUMAN	chromosome 5 open reading frame 55	111						extracellular region				large_intestine(1)|lung(2)	3						CAGCGCGGCCCAGTGACCCAC	0.642000													18	81					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187628340	187628340	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr4:187628340C>T	ENST00000441802.2	-	2	2851	c.2642G>A	c.(2641-2643)cGc>cAc	p.R881H		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	881	Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ATCCAGAGGGCGTGCGATGTT	0.512000										HNSCC(5;0.00058)			5	81					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20939730	20939730	+	Silent	SNP	G	G	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:20939730G>T	ENST00000298925.5	+	7	843	c.690G>T	c.(688-690)ggG>ggT	p.G230G	NELL1_ENST00000357134.5_Silent_p.G202G|NELL1_ENST00000325319.5_Silent_p.G145G|NELL1_ENST00000532434.1_Silent_p.G202G			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	202	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TTATCAAGGGGATCATCCAAG	0.383000													11	95					1.58986e-06	1.76985e-06	1	1	0
TXNL1	9352	broad.mit.edu	37	18	54291579	54291579	+	Silent	SNP	G	G	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr18:54291579G>T	ENST00000217515.6	-	3	513	c.309C>A	c.(307-309)atC>atA	p.I103I	TXNL1_ENST00000590954.1_Silent_p.I103I|TXNL1_ENST00000540155.1_5'UTR	NM_004786.2	NP_004777.1	O43396	TXNL1_HUMAN	thioredoxin-like 1	103	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		AGTGCTGCTTGATTTTTTCTT	0.343000													8	125					0.0381472	0.0392562	1	1	0
WNK3	65267	broad.mit.edu	37	X	54275518	54275518	+	Missense_Mutation	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:54275518T>G	ENST00000354646.2	-	17	3701	c.3263A>C	c.(3262-3264)cAa>cCa	p.Q1088P	WNK3_ENST00000375169.3_Missense_Mutation_p.Q1088P|WNK3_ENST00000375159.2_Missense_Mutation_p.Q1088P	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1088					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						AGTAGTGGGTTGAAGGGTAGT	0.428000													8	32					0	0	1	0	0
TESK2	10420	broad.mit.edu	37	1	45811115	45811115	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:45811115G>C	ENST00000372086.3	-	11	1513	c.1113C>G	c.(1111-1113)atC>atG	p.I371M	TESK2_ENST00000372084.1_Missense_Mutation_p.I342M|TESK2_ENST00000341771.6_Missense_Mutation_p.I342M|TESK2_ENST00000486676.1_5'UTR|TESK2_ENST00000538496.1_Missense_Mutation_p.I288M	NM_007170.2	NP_009101.2	Q96S53	TESK2_HUMAN	testis-specific kinase 2	371					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.I355I(1)		breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	32	Acute lymphoblastic leukemia(166;0.155)					TACGGGAAAAGATATCTGACT	0.557000													5	60					0	0	1	0	0
PDE6G	5148	broad.mit.edu	37	17	79620241	79620241	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:79620241T>C	ENST00000573076.1	-	2	720	c.245A>G	c.(244-246)cAg>cGg	p.Q82R	PDE6G_ENST00000571004.1_Missense_Mutation_p.Q32R|PDE6G_ENST00000574777.1_Intron|PDE6G_ENST00000331056.5_Missense_Mutation_p.Q32R|PDE6G_ENST00000571224.1_Missense_Mutation_p.Q32R			P18545	CNRG_HUMAN	phosphodiesterase 6G, cGMP-specific, rod, gamma	32					platelet activation|visual perception	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			lung(2)|urinary_tract(1)	3	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GGTCTGTCGCTGCTTAAATTT	0.617000													6	118					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76592407	76592407	+	Missense_Mutation	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:76592407T>G	ENST00000307431.8	+	25	4136	c.3751T>G	c.(3751-3753)Ttt>Gtt	p.F1251V	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.F1179V|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.F1203V|RP11-58C22.1_ENST00000563764.1_Intron|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.F1255V	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1252					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TGTTGTGATTTTTATCTTGCT	0.363000													5	43					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													5	30					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51769043	51769043	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:51769043T>C	ENST00000316401.7	+	4	698	c.317T>C	c.(316-318)tTg>tCg	p.L106S	SIGLECL1_ENST00000597824.1_Missense_Mutation_p.L12S|CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000593968.1_3'UTR	NM_173635.1	NP_775906.1			SIGLEC family like 1									p.L106S(1)									AAGAGTTCTTTGGCTGCCCAG	0.537000													15	239					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167182167	167182167	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:167182167C>G	ENST00000519204.1	+	1	227	c.109C>G	c.(109-111)Ctc>Gtc	p.L37V	TENM2_ENST00000518659.1_Intron|TENM2_ENST00000520394.1_Missense_Mutation_p.L37V|TENM2_ENST00000520393.1_Intron|TENM2_ENST00000545108.1_Intron					teneurin transmembrane protein 2																		TGTGAGTTTTCTCCATGGGAA	0.512000													16	234					0	0	1	0	0
PNMA3	29944	broad.mit.edu	37	X	152226294	152226294	+	Silent	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:152226294G>C	ENST00000447306.1	+	2	1218	c.882G>C	c.(880-882)ctG>ctC	p.L294L	PNMA3_ENST00000370264.4_Silent_p.L294L|PNMA3_ENST00000370265.4_Silent_p.L294L	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	294					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					agactcgcctgaaacgagtct	0.483000													4	37					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17985495	17985495	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:17985495G>A	ENST00000222248.3	+	4	845	c.498G>A	c.(496-498)gcG>gcA	p.A166A		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	166					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						ACATCTGGGCGTCGCTCCTGT	0.597000													4	41					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42057194	42057194	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr15:42057194G>A	ENST00000219905.7	+	23	8036	c.7855G>A	c.(7855-7857)Gtt>Att	p.V2619I	MGA_ENST00000545763.1_Missense_Mutation_p.V2410I|MGA_ENST00000389936.4_Missense_Mutation_p.V2580I|MGA_ENST00000570161.1_Missense_Mutation_p.V2619I|MGA_ENST00000566586.1_Missense_Mutation_p.V2410I	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2580						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGTGGTAGCTGTTTCTCCTGA	0.493000													9	123					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98275910	98275910	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:98275910G>C	ENST00000289228.5	-	4	436	c.220C>G	c.(220-222)Ccc>Gcc	p.P74A		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	74						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						TGCTCCATGGGGTAGCGGATG	0.647000													10	186					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64814267	64814267	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:64814267T>C	ENST00000332707.5	+	8	1338	c.809T>C	c.(808-810)gTa>gCa	p.V270A		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	270	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		TTGTGTCAAGTATTACAGTCT	0.343000													5	59					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8486187	8486187	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:8486187T>C	ENST00000381196.4	-	25	3173	c.2630A>G	c.(2629-2631)gAa>gGa	p.E877G	PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.E877G|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.E877G|PTPRD_ENST00000360074.4_Missense_Mutation_p.E864G|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.E855G|PTPRD_ENST00000471274.1_5'UTR	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	877	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AAAGTGATCTTCTTTTTCAGA	0.493000										TSP Lung(15;0.13)			6	63					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606742	142606742	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:142606742C>T	ENST00000265310.1	-	14	2157	c.1809G>A	c.(1807-1809)atG>atA	p.M603I		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	603					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TCCGCTCCAGCATCACTGTGG	0.602000													4	29					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62738106	62738106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr20:62738106G>A	ENST00000369768.1	-	1	418	c.79C>T	c.(79-81)Cag>Tag	p.Q27*		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	27						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CCATTGTCCTGAGAGACGTTG	0.632000													7	93					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91631979	91631979	+	Silent	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:91631979C>G	ENST00000359028.2	+	9	3009	c.2784C>G	c.(2782-2784)gtC>gtG	p.V928V	AKAP9_ENST00000358100.2_Silent_p.V928V|AKAP9_ENST00000356239.3_Silent_p.V916V			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	928	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGTTCTGTCTTTGATGAAG	0.328000			T	BRAF	papillary thyroid								4	58					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37168999	37168999	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:37168999G>A	ENST00000274258.7	-	34	7354	c.3767C>T	c.(3766-3768)tCa>tTa	p.S1256L	C5orf42_ENST00000425232.2_Missense_Mutation_p.S2376L|C5orf42_ENST00000508244.1_Missense_Mutation_p.S2376L			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2376										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AGATGCTCTTGAGGTTGATGG	0.413000													8	147					0	0	1	0	0
PSAP	5660	broad.mit.edu	37	10	73591664	73591664	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:73591664C>T	ENST00000394936.3	-	3	335	c.188G>A	c.(187-189)tGc>tAc	p.C63Y	PSAP_ENST00000394934.1_Missense_Mutation_p.C63Y			P07602	SAP_HUMAN	prosaposin	63	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						GCATATGTCGCAGGGAAGGGA	0.512000													10	82					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49881292	49881292	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:49881292G>A	ENST00000331456.2	-	5	463	c.350C>T	c.(349-351)aCt>aTt	p.T117I	TRAIP_ENST00000473863.1_5'UTR|TRAIP_ENST00000469027.1_Intron	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	117					cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGATACCACAGTAGCATTGCG	0.547000													7	128					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122247396	122247396	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:122247396T>C	ENST00000360356.2	-	11	2607	c.2380A>G	c.(2380-2382)Agt>Ggt	p.S794G	PARP9_ENST00000477522.2_Missense_Mutation_p.S759G|PARP9_ENST00000492382.1_Missense_Mutation_p.S339G|PARP9_ENST00000471785.1_Missense_Mutation_p.S759G	NM_001146102.1|NM_031458.2	NP_001139574.1|NP_113646.2	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	794	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		TCAACCACACTGTCATGACCA	0.463000													6	96					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134074000	134074000	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:134074000G>A	ENST00000534548.2	-	10	1220	c.1156C>T	c.(1156-1158)Cct>Tct	p.P386S		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	386					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TCCCCACAAGGAAGTTTACTG	0.428000													5	58					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13621205	13621205	+	Missense_Mutation	SNP	G	G	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr18:13621205G>T	ENST00000361205.4	+	5	939	c.271G>T	c.(271-273)Gtc>Ttc	p.V91F	LDLRAD4_ENST00000586765.1_Missense_Mutation_p.V54F|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.V91F|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.V54F|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.V14F|LDLRAD4_ENST00000399848.3_Missense_Mutation_p.V91F	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		CCACTACAAAGTCTCCACGCG	0.632000													6	96					0.00116845	0.00126107	1	1	0
CAPSL	133690	broad.mit.edu	37	5	35904743	35904743	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:35904743G>A	ENST00000397367.2	-	5	657	c.531C>T	c.(529-531)acC>acT	p.T177T	CAPSL_ENST00000397366.1_Silent_p.T177T	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	177	EF-hand 4.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ACTCCTCAGGGGTCACCTGCA	0.458000													8	69					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57269042	57269042	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr14:57269042C>T	ENST00000339475.5	-	5	581	c.305G>A	c.(304-306)cGc>cAc	p.R102H	OTX2_ENST00000554788.1_3'UTR|OTX2_ENST00000554559.1_3'UTR|OTX2_ENST00000408990.3_Missense_Mutation_p.R94H|OTX2_ENST00000555006.1_Missense_Mutation_p.R94H	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	94					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding	p.R102H(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CTGTTGTTGGCGGCACTTAGC	0.438000													21	119					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147012311	147012311	+	Silent	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:147012311A>G	ENST00000265272.5	-	13	2175	c.1708T>C	c.(1708-1710)Tta>Cta	p.L570L	JAKMIP2_ENST00000507386.1_Silent_p.L549L|JAKMIP2_ENST00000333010.6_Silent_p.L528L	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	570						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTGTTGTAACCGGTGATTT	0.373000													12	128					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54275485	54275485	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:54275485C>A	ENST00000354646.2	-	17	3734	c.3296G>T	c.(3295-3297)aGa>aTa	p.R1099I	WNK3_ENST00000375169.3_Missense_Mutation_p.R1099I|WNK3_ENST00000375159.2_Missense_Mutation_p.R1099I	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1099					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TTTTGGAGGTCTTTCTCCATC	0.453000													10	42					2.17888e-05	2.38063e-05	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190067540	190067540	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:190067540C>T	ENST00000367462.3	-	8	2140	c.1909G>A	c.(1909-1911)Ggt>Agt	p.G637S	FAM5C_ENST00000534846.1_Missense_Mutation_p.G535S|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		637						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CCATTGGGACCATTGGACTTG	0.418000													16	213					0	0	1	0	0
RRAGD	58528	broad.mit.edu	37	6	90097286	90097286	+	Missense_Mutation	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:90097286T>A	ENST00000369415.4	-	2	448	c.172A>T	c.(172-174)Agc>Tgc	p.S58C	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.2_Intron	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	58					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		ACTTCAGTGCTGAAGGGGTCA	0.463000													41	215					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43259218	43259218	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:43259218C>A	ENST00000404209.4	-	4	1006	c.910G>T	c.(910-912)Gaa>Taa	p.E304*	PSG8_ENST00000401467.2_Nonsense_Mutation_p.E211*|PSG8_ENST00000600709.1_Intron|PSG8_ENST00000406636.3_Nonsense_Mutation_p.E182*|PSG8_ENST00000306511.4_Nonsense_Mutation_p.E304*	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	304	Ig-like C2-type 2.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGTCCTGTTTCATTTCTCGTG	0.483000													23	201					5.45024e-15	6.22382e-15	1	1	0
CEP120	153241	broad.mit.edu	37	5	122748204	122748204	+	Missense_Mutation	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:122748204T>G	ENST00000306467.5	-	4	656	c.352A>C	c.(352-354)Aaa>Caa	p.K118Q	CEP120_ENST00000306481.6_Missense_Mutation_p.K92Q|CEP120_ENST00000328236.5_Missense_Mutation_p.K118Q|CEP120_ENST00000395431.2_Missense_Mutation_p.K118Q			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	118						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TTGGTGTATTTATTACTCAGC	0.373000													5	42					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99483971	99483971	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr13:99483971G>C	ENST00000376460.1	-	40	4395	c.4315C>G	c.(4315-4317)Ctt>Gtt	p.L1439V	DOCK9_ENST00000339416.2_Missense_Mutation_p.L1440V|DOCK9_ENST00000448493.2_3'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1440					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGTTTTTGAAGAAAACACAGG	0.388000													7	33					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229541	8229541	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr4:8229541C>T	ENST00000539824.1	+	12	2266	c.1892C>T	c.(1891-1893)tCa>tTa	p.S631L	SH3TC1_ENST00000245105.3_Missense_Mutation_p.S707L			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	707							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GCGTGGCTCTCAGACTGCTAC	0.652000													6	50					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97852232	97852232	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:97852232G>C	ENST00000354565.2	+	1	691	c.691G>C	c.(691-693)Gat>Cat	p.D231H	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						AAAGAAATCTGATAAAGGTGT	0.378000													6	63					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78685053	78685053	+	Silent	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:78685053T>C	ENST00000436010.2	-	21	4123	c.3126A>G	c.(3124-3126)tcA>tcG	p.S1042S	ROBO1_ENST00000495273.1_Silent_p.S1036S|ROBO1_ENST00000467549.1_Silent_p.S981S|ROBO1_ENST00000464233.1_Silent_p.S1081S			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1081					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGCTGAGGTTTGACTGGATGA	0.502000													14	106					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806417	54806417	+	Missense_Mutation	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:54806417A>G	ENST00000306858.7	+	5	2764	c.2648A>G	c.(2647-2649)gAt>gGt	p.D883G		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	883										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AGGGCAGGAGATGCCTCTGCC	0.438000													4	61					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129911746	129911746	+	Missense_Mutation	SNP	G	G	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:129911746G>T	ENST00000368654.3	-	8	1976	c.1601C>A	c.(1600-1602)aCc>aAc	p.T534N	MKI67_ENST00000368653.3_Missense_Mutation_p.T174N	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	534					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTTCTTTTGGTTGGGGCTTC	0.478000													9	132					1.76689e-08	2.00474e-08	1	1	0
KIAA1033	23325	broad.mit.edu	37	12	105534995	105534995	+	Missense_Mutation	SNP	A	A	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:105534995A>T	ENST00000332180.5	+	18	1845	c.1758A>T	c.(1756-1758)aaA>aaT	p.K586N		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	586					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TCATGAAAAAACTGGATCTTA	0.363000													5	92					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32836593	32836593	+	Missense_Mutation	SNP	A	A	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr13:32836593A>C	ENST00000380250.3	+	53	8256	c.7760A>C	c.(7759-7761)cAg>cCg	p.Q2587P		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2587					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATAATCTGCAGATTTCTGAG	0.398000													9	74					0	0	1	0	0
IL13RA2	3598	broad.mit.edu	37	X	114250332	114250332	+	Silent	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:114250332G>C	ENST00000371936.1	-	4	396	c.147C>G	c.(145-147)ctC>ctG	p.L49L	IL13RA2_ENST00000468224.1_5'UTR|IL13RA2_ENST00000243213.1_Silent_p.L49L			Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2	49	Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	23						ATTGCAAATAGAGATAACCTA	0.358000													4	23					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881247	26881247	+	Nonstop_Mutation	SNP	A	A	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:26881247A>T	ENST00000231021.4	-	12	2540	c.2368T>A	c.(2368-2370)Taa>Aaa	p.*790K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	0					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CAATCCTCTTAGTCTCGGTCA	0.403000													7	137					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160273969	160273969	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr4:160273969G>A	ENST00000264431.4	+	21	3934	c.3515G>A	c.(3514-3516)cGc>cAc	p.R1172H		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1172					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GATGAGAGGCGCCAGAGGCAT	0.478000													11	64					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200279	100200279	+	Missense_Mutation	SNP	T	T	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:100200279T>C	ENST00000547776.2	-	4	571	c.572A>G	c.(571-573)aAc>aGc	p.N191S	ANKS1B_ENST00000329257.7_Missense_Mutation_p.N191S|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	191						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CTTGCGAGTGTTGCAGCTCAT	0.522000													4	46					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46121673	46121673	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:46121673G>A	ENST00000374366.3	-	8	1841	c.1376C>T	c.(1375-1377)tCa>tTa	p.S459L	ZFAND4_ENST00000344646.5_Missense_Mutation_p.S533L|ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Intron			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	533							zinc ion binding										TTTCCCAAGTGAATCAACTTT	0.393000													6	103					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33700335	33700335	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:33700335G>A	ENST00000253188.3	-	10	1466	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	440					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					AGATGAAGCTGAAGACCAGCA	0.567000													5	93					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101061540	101061540	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:101061540G>A	ENST00000259455.2	-	17	2967	c.2508C>T	c.(2506-2508)gaC>gaT	p.D836D		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	836					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GGTTGAGGATGTCATTGAGCT	0.493000													12	209					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6592129	6592129	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:6592129C>G	ENST00000254579.6	+	42	13951	c.13387C>G	c.(13387-13389)Caa>Gaa	p.Q4463E	DNHD1_ENST00000527990.2_Missense_Mutation_p.Q4463E	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	4463					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGTGATTCGCCAAGACGAGTC	0.627000													5	53					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204125	9204125	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:9204125G>A	ENST00000429566.3	+	1	271	c.205G>A	c.(205-207)Gtt>Att	p.V69I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V69I(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTGTCCCTGGTTGATTTCTG	0.557000													5	71					0	0	1	0	0
XPO1	7514	broad.mit.edu	37	2	61713034	61713034	+	Missense_Mutation	SNP	G	G	A	rs1802545		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:61713034G>A	ENST00000401558.2	-	20	3104	c.2377C>T	c.(2377-2379)Cca>Tca	p.P793S	XPO1_ENST00000406957.1_Missense_Mutation_p.P793S|XPO1_ENST00000404992.2_Missense_Mutation_p.P793S	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	793					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			CTAGCAGCTGGGACATTTCTC	0.388000			Mis		CLL								4	28					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482117	140482117	+	Missense_Mutation	SNP	G	G	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:140482117G>T	ENST00000231130.2	+	1	1884	c.1884G>T	c.(1882-1884)agG>agT	p.R628S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		628	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCGCCAGGCTGCTGAGCG	0.697000													6	93					0.27861	0.280193	1	1	0
RYR2	6262	broad.mit.edu	37	1	237659909	237659909	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:237659909C>T	ENST00000366574.2	+	20	2377	c.2060C>T	c.(2059-2061)aCa>aTa	p.T687I	RYR2_ENST00000360064.6_Missense_Mutation_p.T685I|RYR2_ENST00000542537.1_Missense_Mutation_p.T671I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	687	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCCTTTGTGACAGCTGAAGCA	0.507000													6	68					0	0	1	0	0
CALCOCO2	10241	broad.mit.edu	37	17	46919124	46919124	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:46919124C>G	ENST00000258947.3	+	2	156	c.55C>G	c.(55-57)Cat>Gat	p.H19D	CALCOCO2_ENST00000508679.1_Intron|CALCOCO2_ENST00000416445.2_Missense_Mutation_p.H19D|CALCOCO2_ENST00000448105.2_Missense_Mutation_p.H19D|CALCOCO2_ENST00000509507.1_Missense_Mutation_p.H19D	NM_001261390.1|NM_001261391.1|NM_001261393.1|NM_001261395.1|NM_005831.4	NP_001248319.1|NP_001248320.1|NP_001248322.1|NP_001248324.1|NP_005822.1	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	19					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	15						GGATCACTGTCATTTCTCTCA	0.483000													4	55					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151545625	151545625	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:151545625G>C	ENST00000232892.6	+	5	991	c.865G>C	c.(865-867)Gag>Cag	p.E289Q	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	289					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCTGCTCCCTGAGAGGTTTAT	0.408000													6	90					0	0	1	0	0
SLC30A10	55532	broad.mit.edu	37	1	220091750	220091750	+	Missense_Mutation	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:220091750T>A	ENST00000366926.3	-	3	966	c.805A>T	c.(805-807)Agt>Tgt	p.S269C	SLC30A10_ENST00000484079.1_5'UTR|SLC30A10_ENST00000536446.1_Missense_Mutation_p.S24C	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	269					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GGGTCCTCACTCTTCAGGGGA	0.512000													6	119					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109965820	109965820	+	Silent	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:109965820A>G	ENST00000424296.2	-	9	907	c.831T>C	c.(829-831)ttT>ttC	p.F277F	AK9_ENST00000341338.6_5'UTR|AK9_ENST00000285397.5_Silent_p.F277F|AK9_ENST00000368948.2_Silent_p.F277F	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		CACTCACCATAAAGAGCTCCT	0.333000													13	92					0	0	1	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197187	26197187	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:26197187C>T	ENST00000377831.5	-	2	745	c.292G>A	c.(292-294)Gag>Aag	p.E98K	HIST1H3D_ENST00000356476.2_Missense_Mutation_p.E98K	NM_003530.3	NP_003521.2	P68431	H31_HUMAN	histone cluster 1, H3d	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.E98*(1)		NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)	14		all_hematologic(11;0.196)				AGGTAGGCCTCGCAGGCCTCC	0.587000													6	71					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134278	119134278	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:119134278G>A	ENST00000264245.4	+	12	4034	c.3502G>A	c.(3502-3504)Gtt>Att	p.V1168I		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1168					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CCTGGACATTGTTGCTCATGC	0.567000													11	57					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150377891	150377891	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:150377891G>C	ENST00000295910.6	-	14	1832	c.1780C>G	c.(1780-1782)Ctt>Gtt	p.L594V	FAM194A_ENST00000491361.1_Missense_Mutation_p.L448V	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	594										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						AGCAGAAGAAGGTCATCTCCA	0.433000													12	128					0	0	1	0	0
EIF3E	3646	broad.mit.edu	37	8	109215343	109215343	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr8:109215343G>A	ENST00000220849.5	-	12	1230	c.1168C>T	c.(1168-1170)Cat>Tat	p.H390Y	EIF3E_ENST00000519030.1_Missense_Mutation_p.H297Y	NM_001568.2	NP_001559.1	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3, subunit E	390	PCI.|Sufficient for interaction with MCM7.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding		EIF3E/RSPO2(6)	NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			ATAACCACATGACCCTAAAAG	0.383000													10	73					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148596606	148596606	+	Missense_Mutation	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:148596606A>G	ENST00000506113.1	+	7	1236	c.754A>G	c.(754-756)Aca>Gca	p.T252A	ABLIM3_ENST00000508983.1_Missense_Mutation_p.T252A|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000326685.7_Missense_Mutation_p.T252A|ABLIM3_ENST00000309868.7_Missense_Mutation_p.T252A|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000356541.3_Missense_Mutation_p.T252A|ABLIM3_ENST00000504238.1_Missense_Mutation_p.T252A|AC012613.2_ENST00000523176.1_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	252	LIM zinc-binding 4.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGTACCTCACAGGTAAGTA	0.502000													10	40					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110256075	110256075	+	Silent	SNP	A	A	G	rs2479390	by1000genomes	TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:110256075A>G	ENST00000369813.1	+	2	929	c.24A>G	c.(22-24)caA>caG	p.Q8Q	GSTM5_ENST00000256593.3_Intron|GSTM5_ENST00000369812.5_Silent_p.Q68Q			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST N-terminal.|Glutathione binding (By similarity).				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TGGTGGCCCAACTGAGCTTCC	0.572000													5	96					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167863154	167863154	+	Silent	SNP	C	C	T	rs148864018		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:167863154C>T	ENST00000367848.1	-	8	986	c.489G>A	c.(487-489)ctG>ctA	p.L163L	ADCY10_ENST00000367851.4_Silent_p.L255L|ADCY10_ENST00000545172.1_Silent_p.L102L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	255	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						GATCAGGCTTCAGCGTGCATG	0.488000													4	33					0	0	1	0	0
NASP	4678	broad.mit.edu	37	1	46067955	46067955	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:46067955C>T	ENST00000350030.3	+	3	223	c.136C>T	c.(136-138)Cta>Tta	p.L46L	NASP_ENST00000537798.1_Intron|NASP_ENST00000351223.3_Silent_p.L46L|NASP_ENST00000372052.4_Silent_p.L46L|NASP_ENST00000402363.3_Silent_p.L48L	NM_002482.3	NP_002473.2	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein (histone-binding)	46					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	17	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AGCTAAGAAACTATTGGGTTT	0.358000													7	69					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75527635	75527635	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:75527635C>G	ENST00000339365.2	+	16	2213	c.2051C>G	c.(2050-2052)gCc>gGc	p.A684G	SEC24C_ENST00000345254.4_Missense_Mutation_p.A684G|SEC24C_ENST00000411652.2_Missense_Mutation_p.A565G|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000535742.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	684					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					CAGACCCTGGCCAAAGAGTGT	0.512000													9	132					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133311022	133311022	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:133311022G>C	ENST00000539605.1	-	9	8338	c.1654C>G	c.(1654-1656)Caa>Gaa	p.Q552E	ANKLE2_ENST00000357997.5_Missense_Mutation_p.Q614E|ANKLE2_ENST00000337516.5_Missense_Mutation_p.Q614E|ANKLE2_ENST00000542374.1_5'UTR			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	614						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CCTGTTTCTTGTTGAGCCTTT	0.537000													12	93					0	0	1	0	0
TYMS	7298	broad.mit.edu	37	18	662209	662209	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr18:662209C>G	ENST00000323274.10	+	3	482	c.343C>G	c.(343-345)Cga>Gga	p.R115G	TYMS_ENST00000323224.7_Missense_Mutation_p.R115G|TYMS_ENST00000323250.5_Intron	NM_001071.2	NP_001062.1	P04818	TYSY_HUMAN	thymidylate synthetase	115					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity			endometrium(1)|large_intestine(3)|lung(2)|urinary_tract(2)	8					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	CAATGGATCCCGAGACTTTTT	0.522000													15	362					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85954813	85954813	+	Silent	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:85954813C>G	ENST00000268638.5	+	9	1628	c.1206C>G	c.(1204-1206)gtC>gtG	p.V402V	IRF8_ENST00000562492.1_Silent_p.V198V	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	402					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				CAGACCAGGTCTTCCGGATGT	0.582000													5	87					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12905742	12905742	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:12905742C>A	ENST00000380659.3	+	3	2254	c.2115C>A	c.(2113-2115)gaC>gaA	p.D705E		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	705					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	AAACTTTGGACCTCAGCCACA	0.418000													9	55					7.48243e-07	8.4356e-07	1	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28302319	28302319	+	Missense_Mutation	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr21:28302319A>G	ENST00000284987.5	-	7	2232	c.2111T>C	c.(2110-2112)gTg>gCg	p.V704A	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	704	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GCCAGTTCTCACACACTTCCC	0.498000													16	165					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58048864	58048864	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:58048864G>C	ENST00000376233.3	+	4	673	c.492G>C	c.(490-492)gaG>gaC	p.E164D	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.E151D|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAAGGAGGAGAGCAGTGCCT	0.463000													5	69					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188574	140188574	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:140188574C>G	ENST00000530339.1	+	1	1802	c.1802C>G	c.(1801-1803)tCg>tGg	p.S601W	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.S601W|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.S601W	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGCTGACTCGGGCTACAAC	0.687000													6	82					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81157274	81157274	+	RNA	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:81157274G>A	ENST00000525539.1	-	0	6464				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CTGGTCTCTAGCGTCAGCGTG	0.597000													7	80					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99566019	99566019	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:99566019C>A	ENST00000411734.1	-	3	368	c.363G>T	c.(361-363)gaG>gaT	p.E121D	AZGP1_ENST00000292401.4_Missense_Mutation_p.E124D			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	124					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TATTCTCGATCTCACAACCAA	0.453000													15	270					0.0285812	0.0297581	1	1	0
PTH2R	5746	broad.mit.edu	37	2	209271779	209271779	+	Missense_Mutation	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:209271779T>A	ENST00000272847.2	+	1	224	c.11T>A	c.(10-12)cTg>cAg	p.L4Q	PTH2R_ENST00000413482.1_Intron	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	4						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		ATGGCCGGGCTGGGGGCGTCG	0.652000													15	88					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96752271	96752271	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr14:96752271C>G	ENST00000359933.4	-	42	6951	c.6058G>C	c.(6058-6060)Gag>Cag	p.E2020Q		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	2020										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CCTCTGCTCTCGTGTTCTCGA	0.562000													3	28					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151877213	151877213	+	Splice_Site	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:151877213T>G	ENST00000355193.2	-	37	7368		c.e37-2		KMT2C_ENST00000262189.6_Splice_Site					lysine (K)-specific methyltransferase 2C																		CTTCTGCCGCTAAATGGGAAG	0.433000													30	143					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79590500	79590500	+	Splice_Site	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:79590500G>A	ENST00000372391.2	-	10	1885	c.1881_splice	c.e10+1	p.T627_splice	DLG5_ENST00000372388.2_Splice_Site_p.T627_splice	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	627	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GCAGCTTACCGTCTCCCTCTC	0.557000													9	75					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861037	55861037	+	Missense_Mutation	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:55861037T>A	ENST00000302124.2	+	1	285	c.254T>A	c.(253-255)tTc>tAc	p.F85Y	OR8I2_ENST00000560768.1_Missense_Mutation_p.F85Y			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TTGGTGAATTTCCAATCCAAT	0.393000													13	191					0	0	1	0	0
RRAGD	58528	broad.mit.edu	37	6	90097287	90097287	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:90097287G>A	ENST00000369415.4	-	2	447	c.171C>T	c.(169-171)ttC>ttT	p.F57F	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.2_Intron	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	57					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CTTCAGTGCTGAAGGGGTCAC	0.458000													41	216					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52618487	52618487	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:52618487G>C	ENST00000600228.1	-	4	2191	c.1930C>G	c.(1930-1932)Cag>Gag	p.Q644E	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TGGACACGCTGACTAAAGGAA	0.428000													6	126					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58299774	58299774	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:58299774C>G	ENST00000300896.4	-	15	1939	c.1745G>C	c.(1744-1746)aGa>aCa	p.R582T	USP32_ENST00000592339.1_Missense_Mutation_p.R252T	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	582	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACTTACTGGTCTAGGTAAGGC	0.433000													32	350					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179736895	179736895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:179736895G>A	ENST00000420890.2	-	13	2161	c.2044C>T	c.(2044-2046)Cag>Tag	p.Q682*	CCDC141_ENST00000295723.5_Nonsense_Mutation_p.Q107*	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	107							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GCCCACTGCTGTTTTCCAGGC	0.483000													5	47					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6061619	6061619	+	Missense_Mutation	SNP	A	A	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:6061619A>T	ENST00000261405.5	-	49	8307	c.8053T>A	c.(8053-8055)Ttc>Atc	p.F2685I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2685					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TTCTCCCAGAAGTACTCTCCT	0.502000													7	45					0	0	1	0	0
KIAA0895	23366	broad.mit.edu	37	7	36397094	36397094	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:36397094C>G	ENST00000317020.6	-	2	431	c.131G>C	c.(130-132)gGa>gCa	p.G44A	KIAA0895_ENST00000297063.6_Missense_Mutation_p.G95A|KIAA0895_ENST00000453212.1_Intron|KIAA0895_ENST00000415803.2_Missense_Mutation_p.G82A|KIAA0895_ENST00000338533.5_Missense_Mutation_p.G82A|KIAA0895_ENST00000480192.1_Intron|KIAA0895_ENST00000436884.1_5'UTR|KIAA0895_ENST00000440378.1_Missense_Mutation_p.G44A	NM_015314.2	NP_056129.2	Q8NCT3	K0895_HUMAN	KIAA0895	95	Arg-rich.									breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TTTTAGCACTCCCGAGGACAA	0.388000													5	53					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40653348	40653348	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:40653348G>A	ENST00000298910.7	+	13	1543	c.1485G>A	c.(1483-1485)gaG>gaA	p.E495E	LRRK2_ENST00000343742.2_Silent_p.E495E	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	495					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AACGTCATGAGACATCATTAC	0.393000													9	76					0	0	1	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24511938	24511938	+	RNA	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr14:24511938G>A	ENST00000558293.1	+	0	437					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		TATCACTATCGATAACAAACT	0.453000													7	121					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105752861	105752861	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:105752861C>G	ENST00000369755.3	+	4	1029	c.484C>G	c.(484-486)Ctc>Gtc	p.L162V	SLK_ENST00000335753.4_Missense_Mutation_p.L162V	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	162	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGGCAACATTCTCTTTACCTT	0.323000													8	60					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65427052	65427052	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:65427052C>A	ENST00000519389.1	+	14	2648	c.2469C>A	c.(2467-2469)ttC>ttA	p.F823L	HEPH_ENST00000336279.5_Missense_Mutation_p.F502L|HEPH_ENST00000374727.3_Missense_Mutation_p.F772L|HEPH_ENST00000343002.2_Missense_Mutation_p.F769L|HEPH_ENST00000419594.1_Missense_Mutation_p.F580L|HEPH_ENST00000441993.2_Missense_Mutation_p.F772L			Q9BQS7	HEPH_HUMAN	hephaestin	769	Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GTTACATTTTCCTGAGCAACA	0.453000													6	15					2.0095e-06	2.22301e-06	1	1	0
SSX6	280657	broad.mit.edu	37	X	47972595	47972595	+	Silent	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:47972595T>A	ENST00000319275.3	+	5	372	c.6T>A	c.(4-6)acT>acA	p.T2T	SSX6_ENST00000376932.2_Silent_p.T100T																large_intestine(6)|lung(4)|skin(2)|stomach(1)	13						CTCAGATGACTTTTGGCAGGC	0.443000													14	59					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26598010	26598010	+	Missense_Mutation	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:26598010A>G	ENST00000260585.7	+	6	795	c.676A>G	c.(676-678)Att>Gtt	p.I226V		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	226					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										CACTGCAATGATTATTGGTAA	0.383000													6	110					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25332817	25332817	+	RNA	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr15:25332817G>A	ENST00000546682.1	+	0	586				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA|SNORD116-21_ENST00000384529.1_lincRNA	NR_003361.1																						GTGGATCGATGATGACTTCCA	0.428000													9	165					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114299660	114299660	+	Missense_Mutation	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:114299660C>T	ENST00000408937.3	+	14	2028	c.1654C>T	c.(1654-1656)Ctt>Ttt	p.L552F	FOXP2_ENST00000393500.3_3'UTR|FOXP2_ENST00000403559.4_Missense_Mutation_p.L544F|FOXP2_ENST00000393489.3_Missense_Mutation_p.L435F|FOXP2_ENST00000393491.3_Missense_Mutation_p.L342F|FOXP2_ENST00000393494.2_Missense_Mutation_p.L527F|FOXP2_ENST00000393498.2_Missense_Mutation_p.L506F|FOXP2_ENST00000350908.4_Missense_Mutation_p.L527F	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	527					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GCAGTTAACACTTAATGAAAT	0.378000													10	95					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127548237	127548237	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:127548237G>A	ENST00000284690.3	-	3	1274	c.784C>T	c.(784-786)Ctt>Ttt	p.L262F	DHX32_ENST00000284688.6_Missense_Mutation_p.L262F	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	262						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TCAAAGATAAGGCGTAAAATA	0.393000													11	65					0	0	1	0	0
TMEM30A	55754	broad.mit.edu	37	6	75994297	75994297	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr6:75994297C>G	ENST00000230461.6	-	1	387	c.58G>C	c.(58-60)Ggg>Cgg	p.G20R	TMEM30A_ENST00000475111.2_Missense_Mutation_p.G20R	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	20						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCGGTGCCCCCCGGAGCACAC	0.637000													10	125					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131504097	131504097	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:131504097C>T	ENST00000291900.2	-	10	2005	c.1599G>A	c.(1597-1599)aaG>aaA	p.K533K		NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	533					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						CCAGCAGCTTCTTCTGAATCA	0.587000													9	125					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182147	140182147	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr5:140182147C>A	ENST00000522353.2	+	1	1365	c.1365C>A	c.(1363-1365)ttC>ttA	p.F455L	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.F455L|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGCATTCTCGCAGTCCG	0.672000													9	134					1.12685e-05	1.23884e-05	1	1	0
CALCA	796	broad.mit.edu	37	11	14991612	14991612	+	Silent	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:14991612C>G	ENST00000361010.3	-	3	170	c.96G>C	c.(94-96)ctG>ctC	p.L32L	CALCA_ENST00000359642.3_Silent_p.L32L|CALCA_ENST00000331587.4_Silent_p.L32L|CALCA_ENST00000396372.2_Silent_p.L32L|CALCB_ENST00000523376.1_Intron|CALCA_ENST00000486207.1_Silent_p.L32L	NM_001033953.2	NP_001029125.1	P06881	CALCA_HUMAN	calcitonin-related polypeptide alpha	32					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	8					Phentolamine(DB00692)	GGCTGCTCTCCAGGGCAGACC	0.627000											OREG0020791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	29					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101731899	101731899	+	Missense_Mutation	SNP	A	A	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr12:101731899A>G	ENST00000261637.4	+	30	3886	c.3712A>G	c.(3712-3714)Att>Gtt	p.I1238V		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1238					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TGTTTTTGCAATTCTCTCAGC	0.408000													8	97					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62724085	62724085	+	Silent	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr20:62724085C>G	ENST00000349451.3	+	4	424	c.12C>G	c.(10-12)ctC>ctG	p.L4L	OPRL1_ENST00000355631.4_Silent_p.L4L|OPRL1_ENST00000336866.2_Silent_p.L4L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	4					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TGGAGCCCCTCTTCCCCGCGC	0.642000													5	68					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97174523	97174523	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr10:97174523G>A	ENST00000371247.2	-	9	727	c.538C>T	c.(538-540)Cca>Tca	p.P180S	SORBS1_ENST00000371239.1_Intron|SORBS1_ENST00000371227.4_Missense_Mutation_p.P180S|SORBS1_ENST00000277982.5_Missense_Mutation_p.P180S|SORBS1_ENST00000371241.1_Intron|SORBS1_ENST00000306402.6_Intron|SORBS1_ENST00000607232.1_Intron|SORBS1_ENST00000371246.2_Missense_Mutation_p.P180S|SORBS1_ENST00000347291.4_Intron|SORBS1_ENST00000371249.2_Missense_Mutation_p.P148S|SORBS1_ENST00000353505.5_Intron|SORBS1_ENST00000393949.1_Missense_Mutation_p.P171S|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000361941.3_Missense_Mutation_p.P180S|SORBS1_ENST00000371245.3_Intron|SORBS1_ENST00000354106.3_Missense_Mutation_p.P171S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	180					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AGAGGTGTTGGAGGTCTGGCA	0.582000													7	53					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095545	103095545	+	Silent	SNP	C	C	T			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:103095545C>T	ENST00000295269.4	+	2	961	c.504C>T	c.(502-504)atC>atT	p.I168I		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	168					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GGGCCCTGATCAACGCCTTGG	0.617000													4	49					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233898902	233898902	+	Missense_Mutation	SNP	C	C	T	rs140090973	byFrequency	TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:233898902C>T	ENST00000233840.3	+	2	278	c.278C>T	c.(277-279)gCg>gTg	p.A93V		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	93							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TTGTATGACGCGCAGACGGGG	0.612000													7	68					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51696547	51696547	+	Missense_Mutation	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr3:51696547G>A	ENST00000409535.1	+	22	3640	c.3515G>A	c.(3514-3516)aGc>aAc	p.S1172N	RAD54L2_ENST00000296477.3_Missense_Mutation_p.S866N	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1172						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TCTCCTGACAGCCCAGAGATC	0.637000													6	72					0	0	1	0	0
IL13RA2	3598	broad.mit.edu	37	X	114250373	114250373	+	Missense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:114250373G>C	ENST00000371936.1	-	4	355	c.106C>G	c.(106-108)Cag>Gag	p.Q36E	IL13RA2_ENST00000468224.1_5'UTR|IL13RA2_ENST00000243213.1_Missense_Mutation_p.Q36E			Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2	36	Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	23						TCAAAATCCTGAGGAGGGTTA	0.353000													4	21					0	0	1	0	0
SDAD1	55153	broad.mit.edu	37	4	76877194	76877194	+	Silent	SNP	G	G	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr4:76877194G>A	ENST00000356260.5	-	21	2068	c.1950C>T	c.(1948-1950)aaC>aaT	p.N650N	AC110615.1_ENST00000599764.1_Silent_p.K46K|SDAD1_ENST00000395711.4_Silent_p.N613N	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	650					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCATCATAAAGTTCTTCTGTT	0.403000													16	95					0	0	1	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128946763	128946763	+	Silent	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chrX:128946763G>C	ENST00000357166.6	-	8	1099	c.708C>G	c.(706-708)ctC>ctG	p.L236L	ZDHHC9_ENST00000371064.3_Silent_p.L236L	NM_016032.3	NP_057116.2	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC-type containing 9	236						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	19						CGACGGACCAGAGTGTAAAGA	0.463000													7	51					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45173597	45173597	+	Silent	SNP	C	C	G	rs138572525		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr21:45173597C>G	ENST00000291565.4	+	9	939	c.756C>G	c.(754-756)ctC>ctG	p.L252L	PDXK_ENST00000467908.1_Silent_p.L212L|PDXK_ENST00000468090.1_Silent_p.L224L	NM_003681.4	NP_003672.1	O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	252					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding	p.L252L(2)		endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCAATAACCTCAAGGTCAGCC	0.622000													6	68					0	0	1	0	0
OR1B1	347169	broad.mit.edu	37	9	125391113	125391113	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:125391113C>G	ENST00000304833.3	-	1	739	c.702G>C	c.(700-702)ttG>ttC	p.L234F	RP11-64P14.7_ENST00000431442.1_RNA|RP11-64P14.7_ENST00000419604.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						CAGCTGAAGGCAAACGTAGAA	0.547000													6	70					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111387323	111387323	+	Splice_Site	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr7:111387323C>A	ENST00000428084.1	-	43	4865	c.4593_splice	c.e43+1	p.E1531_splice	DOCK4_ENST00000494651.2_Splice_Site_p.E405_splice|DOCK4_ENST00000437633.1_Splice_Site_p.E1522_splice			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1522	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TAATCCTTACCTCTTGATACC	0.393000													4	29					0.150653	0.154137	1	1	0
S100A11	6282	broad.mit.edu	37	1	152006272	152006272	+	Missense_Mutation	SNP	T	T	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:152006272T>G	ENST00000271638.2	-	2	127	c.8A>C	c.(7-9)aAa>aCa	p.K3T	NBPF18P_ENST00000432386.1_RNA|S100A11_ENST00000478109.1_5'UTR	NM_005620.1	NP_005611.1	P31949	S10AB_HUMAN	S100 calcium binding protein A11	3					negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding			large_intestine(1)|lung(1)|prostate(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTGGAGATTTTTGCCTTTGG	0.468000													8	76					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844831	128844831	+	Missense_Mutation	SNP	T	T	C	rs149902728		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:128844831T>C	ENST00000310343.9	-	20	2218	c.2219A>G	c.(2218-2220)aAt>aGt	p.N740S	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.N666S|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.N391S|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.N391S	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	740					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CATTTCTCCATTAAAAGAGGC	0.458000													8	57					0	0	1	0	0
RNH1	6050	broad.mit.edu	37	11	498910	498910	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr11:498910G>C	ENST00000534797.1	-	5	2045	c.638C>G	c.(637-639)tCa>tGa	p.S213*	RNH1_ENST00000397614.1_Nonsense_Mutation_p.S213*|RNH1_ENST00000533410.1_Nonsense_Mutation_p.S213*|RNH1_ENST00000397604.3_Nonsense_Mutation_p.S213*|RNH1_ENST00000438658.2_Nonsense_Mutation_p.S213*|RNH1_ENST00000397615.2_Nonsense_Mutation_p.S213*|RNH1_ENST00000356187.5_Nonsense_Mutation_p.S213*|RNH1_ENST00000354420.2_Nonsense_Mutation_p.S213*			P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor 1	213					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGTTGTCTGATGTCACACC	0.692000													3	23					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33468556	33468556	+	Missense_Mutation	SNP	C	C	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr9:33468556C>A	ENST00000379471.2	-	9	1243	c.1156G>T	c.(1156-1158)Gac>Tac	p.D386Y	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Missense_Mutation_p.D326Y			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	386					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		ACTGTCAGGTCTGTAGTGGCT	0.522000													7	97					0.0293803	0.0304112	1	1	0
PSG8	440533	broad.mit.edu	37	19	43259217	43259217	+	Missense_Mutation	SNP	T	T	A			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr19:43259217T>A	ENST00000404209.4	-	4	1007	c.911A>T	c.(910-912)gAa>gTa	p.E304V	PSG8_ENST00000401467.2_Missense_Mutation_p.E211V|PSG8_ENST00000600709.1_Intron|PSG8_ENST00000406636.3_Missense_Mutation_p.E182V|PSG8_ENST00000306511.4_Missense_Mutation_p.E304V	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	304	Ig-like C2-type 2.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGGTCCTGTTTCATTTCTCGT	0.478000													23	201					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230266	21230266	+	Missense_Mutation	SNP	C	C	G			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr2:21230266C>G	ENST00000233242.1	-	26	9601	c.9474G>C	c.(9472-9474)ttG>ttC	p.L3158F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3158					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGAATTCCTTCAAGCCTGTTT	0.353000													5	89					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109312	145109313	+	RNA	INS	-	-	A	rs148903206		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr1:145109312_145109313insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										aaaccaaaaacaaaAAAAAAAG	0.416													2	4	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81213789	81213794	+	RNA	DEL	CACACA	CACACA	-	rs71266069		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr8:81213789_81213794delCACACA	ENST00000522044.1	+	0	404																											CCCCCACCACcacacacacacacaca	0.544													3	3	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74378976	74378977	+	RNA	DEL	TT	TT	-	rs35591542		TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr16:74378976_74378977delTT	ENST00000429810.2	-	0	1086																											ACCTCTTGAAtttttttttttt	0.421													2	4	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7812610	7812610	+	Frame_Shift_Del	DEL	G	G	-			TCGA-93-A4JQ-01A-11D-A24P-08	TCGA-93-A4JQ-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b0151f6-1b38-484f-a4fc-6543e8c355f2	ec83babf-e878-4b15-b502-68b719a78795	g.chr17:7812610delG	ENST00000380358.4	+	37	5722	c.5721delG	c.(5719-5721)aafs	p.K1907fs	CHD3_ENST00000358181.4_Frame_Shift_Del_p.K1814fs|CHD3_ENST00000330494.7_Frame_Shift_Del_p.K1848fs	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1848	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				ACCTCTCCAAGGAGTCGCTGG	0.726													2	4	---	---	---	---					
