Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADRB2	154	broad.mit.edu	37	5	148206584	148206584	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:148206584C>T	ENST00000305988.4	+	1	429	c.190C>T	c.(190-192)Ctg>Ttg	p.L64L		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	64					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GTTCGAGCGTCTGCAGACGGT	0.562000													15	28					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121825239	121825239	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:121825239G>A	ENST00000330540.2	+	4	711	c.595G>A	c.(595-597)Gtt>Att	p.V199I	CD86_ENST00000493101.1_Missense_Mutation_p.V87I|CD86_ENST00000264468.5_Intron|CD86_ENST00000469710.1_Missense_Mutation_p.V117I|CD86_ENST00000393627.2_Missense_Mutation_p.V193I	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	199	Ig-like C2-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	ACTGTACGACGTTTCCATCAG	0.393000													36	135					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115961190	115961190	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr9:115961190G>A	ENST00000238256.3	-	8	779	c.662C>T	c.(661-663)aCt>aTt	p.T221I		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	221	PPIase FKBP-type.				endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						TTTGTTAGCAGTGGAGTCGAA	0.353000													4	8					0	0	1	0	0
ANKRD23	200539	broad.mit.edu	37	2	97506529	97506529	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:97506529C>T	ENST00000318357.4	-	4	462	c.421G>A	c.(421-423)Gac>Aac	p.D141N	ANKRD23_ENST00000476975.1_Intron|ANKRD23_ENST00000331001.2_Intron|ANKRD23_ENST00000418232.1_Missense_Mutation_p.D141N	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	141						nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						GCTACCTTGTCATGGGCATTG	0.592000													39	138					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141545328	141545328	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:141545328C>A	ENST00000442267.2	-	20	3094	c.3020G>T	c.(3019-3021)tGg>tTg	p.W1007L		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1007						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTCTGGAGTCCACAGTCTCAA	0.353000													4	21					0.014758	0.0153006	1	1	0
PRMT3	10196	broad.mit.edu	37	11	20417373	20417373	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr11:20417373T>G	ENST00000331079.6	+	6	642	c.425T>G	c.(424-426)gTg>gGg	p.V142G	PRMT3_ENST00000437750.2_Missense_Mutation_p.V80G	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	142							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						TATGAACCGGTGTCAGTACCC	0.353000													15	58					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42680029	42680029	+	Silent	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:42680029C>A	ENST00000358131.5	+	4	730	c.522C>A	c.(520-522)gcC>gcA	p.A174A	TOX2_ENST00000435864.2_Silent_p.A43A|TOX2_ENST00000423191.1_Silent_p.A123A|TOX2_ENST00000372999.1_Silent_p.A123A|TOX2_ENST00000341197.3_Silent_p.A165A	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CAATGCTGGCCAGCCACATGA	0.662000													6	32					0.00448238	0.00471654	1	1	0
BPTF	2186	broad.mit.edu	37	17	65925581	65925581	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:65925581G>T	ENST00000321892.4	+	19	6567	c.6506G>T	c.(6505-6507)gGa>gTa	p.G2169V	BPTF_ENST00000335221.5_Missense_Mutation_p.G2169V|BPTF_ENST00000424123.3_Missense_Mutation_p.G2030V|BPTF_ENST00000306378.6_Missense_Mutation_p.G2043V			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2169					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TCAGGCTCTGGAGGAACCACA	0.408000													12	58					1.3612e-06	1.44308e-06	1	1	0
ZNF160	90338	broad.mit.edu	37	19	53572735	53572735	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:53572735C>G	ENST00000601421.1	-	3	1820	c.944G>C	c.(943-945)aGa>aCa	p.R315T	ZNF160_ENST00000429604.1_Missense_Mutation_p.R351T|ZNF160_ENST00000418871.1_Missense_Mutation_p.R351T|ZNF160_ENST00000599056.1_Missense_Mutation_p.R351T			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	351					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		TGAATGTCCTCTAAAGGCTTT	0.403000													25	54					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	988794	988794	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:988794C>T	ENST00000315939.6	+	11	3072	c.2429C>T	c.(2428-2430)gCg>gTg	p.A810V	WNK1_ENST00000530271.2_Missense_Mutation_p.A1308V|WNK1_ENST00000340908.4_Missense_Mutation_p.A403V|WNK1_ENST00000537687.1_Intron|WNK1_ENST00000535572.1_Intron	NM_018979.3	NP_061852.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	810					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ATCCCAGTTGCGACACAACCC	0.507000													28	90					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152499796	152499796	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:152499796C>T	ENST00000427231.2	-	58	8230	c.8028G>A	c.(8026-8028)gaG>gaA	p.E2676E	NEB_ENST00000409198.1_Silent_p.E2676E|NEB_ENST00000172853.10_Silent_p.E2676E|NEB_ENST00000397345.3_Silent_p.E2676E|NEB_ENST00000603639.1_Silent_p.E2676E|NEB_ENST00000604864.1_Silent_p.E2676E	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2676					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTTTATTTTTCTCATCCTCGA	0.413000													23	56					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173996886	173996886	+	Silent	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:173996886A>C	ENST00000457714.1	+	6	1524	c.1095A>C	c.(1093-1095)atA>atC	p.I365I	NLGN1_ENST00000401917.3_Silent_p.I405I|NLGN1_ENST00000361589.4_Silent_p.I365I|NLGN1_ENST00000545397.1_Silent_p.I365I|NLGN1_ENST00000466350.1_3'UTR	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	382					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTGATGTAATACCAGACGACC	0.403000													41	169					0	0	1	0	0
KREMEN2	79412	broad.mit.edu	37	16	3016183	3016183	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr16:3016183G>A	ENST00000572045.1	+	3	617	c.312G>A	c.(310-312)gaG>gaA	p.E104E	KREMEN2_ENST00000319500.6_Silent_p.E104E|KREMEN2_ENST00000303746.5_Silent_p.E104E|KREMEN2_ENST00000575769.1_Silent_p.E104E|KREMEN2_ENST00000571007.1_Silent_p.E104E|KREMEN2_ENST00000575885.1_Silent_p.E104E	NM_172229.2	NP_757384.1	Q8NCW0	KREM2_HUMAN	kringle containing transmembrane protein 2	104	Kringle.				Wnt receptor signaling pathway	integral to membrane				central_nervous_system(2)|endometrium(1)|large_intestine(1)	4						ACGTGGCTGAGACAGAGGAGG	0.637000													30	103					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104205098	104205098	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr14:104205098C>A	ENST00000202556.9	-	14	3064	c.2782G>T	c.(2782-2784)Gcc>Tcc	p.A928S	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_Missense_Mutation_p.A347S	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	928					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GCGCAGACGGCGTTGTGCAGT	0.607000													39	116					2.13384e-23	2.54976e-23	1	1	0
SBSN	374897	broad.mit.edu	37	19	36015641	36015641	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:36015641G>T	ENST00000452271.2	-	3	1749	c.1721C>A	c.(1720-1722)cCt>cAt	p.P574H	SBSN_ENST00000518157.1_Missense_Mutation_p.P231H	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	231						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GTTGATGAAAGGCGTGTTGAC	0.597000													18	52					6.33239e-15	7.20054e-15	1	1	0
TG	7038	broad.mit.edu	37	8	133895218	133895218	+	Missense_Mutation	SNP	G	G	A	rs113998044	by1000genomes	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr8:133895218G>A	ENST00000220616.4	+	8	1089	c.1049G>A	c.(1048-1050)cGg>cAg	p.R350Q	TG_ENST00000377869.1_Missense_Mutation_p.R350Q	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	350	Thyroglobulin type-1 4.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CATGGAACCCGGCAGCAAGGG	0.617000													3	23					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	12011	12011	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrM:12011T>C	ENST00000361381.2	+	1	1252	c.1252T>C	c.(1252-1254)Tca>Cca	p.418_418insP						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CACAATGGGGCTCACTCACCC	0.453000													22	11					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361160	70361160	+	Silent	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:70361160T>C	ENST00000305107.6	-	1	466	c.420A>G	c.(418-420)ctA>ctG	p.L140L	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Silent_p.L140L|UGT2B4_ENST00000381096.3_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	140					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TTGACTCCTGTAGTTTCTTCA	0.368000													5	16					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98080419	98080419	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:98080419T>G	ENST00000419175.1	+	4	722	c.552T>G	c.(550-552)aaT>aaG	p.N184K	DNTT_ENST00000371174.2_Missense_Mutation_p.N184K	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	184	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TTAGAGAAAATGAAGACTCCT	0.443000													22	72					0	0	1	0	0
PSMD3	5709	broad.mit.edu	37	17	38151727	38151727	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:38151727G>A	ENST00000264639.4	+	9	1441	c.1267G>A	c.(1267-1269)Gcc>Acc	p.A423T	PSMD3_ENST00000541736.1_Missense_Mutation_p.A285T	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	423	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					GGCTGACATCGCCCAGAAGCT	0.562000													29	91					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14378302	14378302	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:14378302A>G	ENST00000403951.2	-	23	2382	c.1963T>C	c.(1963-1965)Tct>Cct	p.S655P	DGKB_ENST00000444700.2_Missense_Mutation_p.S636P|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.S655P|DGKB_ENST00000406247.3_Missense_Mutation_p.S655P|DGKB_ENST00000399322.3_Missense_Mutation_p.S655P|DGKB_ENST00000402815.1_Missense_Mutation_p.S654P|DGKB_ENST00000407950.1_Missense_Mutation_p.S647P			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	655					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCTTCCAGAGAGATGTTTATT	0.353000													8	46					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128389852	128389852	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:128389852T>G	ENST00000389524.4	+	38	5259	c.5206T>G	c.(5206-5208)Tgg>Ggg	p.W1736G	MYO7B_ENST00000409090.1_Missense_Mutation_p.W588G|MYO7B_ENST00000428314.1_Missense_Mutation_p.W1735G|MYO7B_ENST00000409816.2_Missense_Mutation_p.W1735G			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1735	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCAGCTGCTGTGGCTGTGCAC	0.677000													6	23					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21842370	21842370	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:21842370T>A	ENST00000382254.1	-	8	1800	c.714A>T	c.(712-714)caA>caT	p.Q238H	CDH12_ENST00000504376.2_Missense_Mutation_p.Q238H|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Missense_Mutation_p.Q198H	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	238	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TATCCTTGGCTTGGATGAGTA	0.398000										HNSCC(59;0.17)			34	173					0	0	1	0	0
RPP21	79897	broad.mit.edu	37	6	30313016	30313016	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:30313016G>A	ENST00000428040.2	+	1	81	c.68G>A	c.(67-69)cGa>cAa	p.R23Q	RPP21_ENST00000442966.2_Intron|RPP21_ENST00000436442.2_Intron|RPP21_ENST00000433076.2_Intron|RPP21_ENST00000466327.1_Intron|TRIM39-RPP21_ENST00000513556.1_Intron					ribonuclease P/MRP 21kDa subunit											endometrium(2)|ovary(1)|prostate(1)	4						GTGAGTCTGCGACAAGGGCCC	0.706000													8	14					0	0	1	0	0
KCNAB2	8514	broad.mit.edu	37	1	6150513	6150513	+	Silent	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:6150513G>T	ENST00000164247.1	+	10	1044	c.480G>T	c.(478-480)ccG>ccT	p.P160P	KCNAB2_ENST00000378083.3_Silent_p.P193P|KCNAB2_ENST00000378097.1_Silent_p.P160P|KCNAB2_ENST00000352527.1_Silent_p.P146P|KCNAB2_ENST00000341524.1_Silent_p.P160P|KCNAB2_ENST00000602612.1_Silent_p.P160P|KCNAB2_ENST00000378087.3_Intron|KCNAB2_ENST00000378111.1_Intron|KCNAB2_ENST00000458166.2_Silent_p.P93P|KCNAB2_ENST00000378092.1_Silent_p.P146P	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	160						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		CCAACCGCCCGGACCCCAACA	0.662000													8	46					5.4927e-09	6.00365e-09	1	1	0
ACBD5	91452	broad.mit.edu	37	10	27520740	27520740	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:27520740C>A	ENST00000396271.3	-	4	438	c.312G>T	c.(310-312)tgG>tgT	p.W104C	ACBD5_ENST00000375901.1_5'UTR|ACBD5_ENST00000375905.4_Missense_Mutation_p.W69C|ACBD5_ENST00000375897.3_5'UTR|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375888.1_Missense_Mutation_p.W102C	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	102	ACB.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CCAGTGAACTCCAAGCATCCC	0.333000													24	67					2.61193e-14	2.94626e-14	1	1	0
UMPS	7372	broad.mit.edu	37	3	124449468	124449468	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:124449468G>A	ENST00000232607.2	+	1	256	c.150G>A	c.(148-150)ctG>ctA	p.L50L	UMPS_ENST00000413078.2_5'UTR|UMPS_ENST00000536109.1_5'UTR|UMPS_ENST00000538242.1_5'UTR	NM_000373.3	NP_000364.1	P11172	UMPS_HUMAN	uridine monophosphate synthetase	50	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(114;0.146)		CGCGTCTTCTGAGTCAGGTGC	0.587000													13	52					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186336883	186336883	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:186336883G>A	ENST00000264689.6	-	5	588	c.472C>T	c.(472-474)Cca>Tca	p.P158S		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	158						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GTTTCTTCTGGAGCAACAGAT	0.433000													25	94					0	0	1	0	0
DTD1	92675	broad.mit.edu	37	20	18574431	18574431	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:18574431T>A	ENST00000377452.3	+	2	280	c.100T>A	c.(100-102)Tcc>Acc	p.S34T	DTD1_ENST00000494921.1_3'UTR	NM_080820.4	NP_543010.3	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	34					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			large_intestine(4)|lung(1)|ovary(2)	7						GCTGGGTATTTCCCTGGAGGA	0.473000													11	54					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133175319	133175319	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:133175319T>G	ENST00000329321.3	+	1	1173	c.704T>G	c.(703-705)cTg>cGg	p.L235R		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	235						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTCGTGGTCCTGCTCTCCGTA	0.612000													15	73					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119603980	119603980	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:119603980G>A	ENST00000295206.6	-	1	1274	c.764C>T	c.(763-765)tCa>tTa	p.S255L		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	255					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GCCGTTGGCTGAGCCCATAAG	0.667000													4	21					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72520236	72520236	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:72520236C>A	ENST00000373208.1	+	22	3308	c.3308C>A	c.(3307-3309)cCc>cAc	p.P1103H	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.P1100H	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1100	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GCCTCGGGCcccaaccctggc	0.632000													18	59					1.40151e-16	1.61978e-16	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P|FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													7	204					0	0	1	0	0
STK24	8428	broad.mit.edu	37	13	99171719	99171719	+	Missense_Mutation	SNP	C	C	A	rs17855308		TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr13:99171719C>A	ENST00000397517.2	-	2	127	c.51G>T	c.(49-51)aaG>aaT	p.K17N	STK24_ENST00000376547.3_Missense_Mutation_p.K29N|STK24_ENST00000481288.1_5'UTR|STK24_ENST00000539966.1_Missense_Mutation_p.K17N	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	29					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTGGGTCTGCCTTTAGGTTCT	0.418000													22	61					1.28384e-07	1.39247e-07	1	1	0
PLK2	10769	broad.mit.edu	37	5	57751605	57751605	+	Splice_Site	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:57751605G>A	ENST00000274289.3	-	11	1686	c.1384_splice	c.e11-1	p.C462_splice	PLK2_ENST00000502671.1_Intron	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	462					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		TGTCTTCAAGGCCTGAAAAGT	0.423000													18	82					0	0	1	0	0
ZNF302	55900	broad.mit.edu	37	19	35174132	35174132	+	Missense_Mutation	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:35174132A>C	ENST00000505365.2	+	4	539	c.203A>C	c.(202-204)aAa>aCa	p.K68T	ZNF302_ENST00000446502.2_Missense_Mutation_p.K112T|ZNF302_ENST00000423823.2_Missense_Mutation_p.K68T|ZNF302_ENST00000509528.1_Intron|ZNF302_ENST00000507959.1_Missense_Mutation_p.K69T|ZNF302_ENST00000505242.1_Missense_Mutation_p.K68T|ZNF302_ENST00000457781.2_Missense_Mutation_p.K68T			Q9NR11	ZN302_HUMAN	zinc finger protein 302	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ATGGAGAAAAAACTGTCAAAA	0.373000													3	93					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114254316	114254316	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:114254316G>C	ENST00000357077.4	+	29	3384	c.3331G>C	c.(3331-3333)Gac>Cac	p.D1111H	ANK2_ENST00000264366.6_Missense_Mutation_p.D1078H|ANK2_ENST00000509550.1_Missense_Mutation_p.D287H|ANK2_ENST00000506722.1_Missense_Mutation_p.D1102H|ANK2_ENST00000394537.3_Missense_Mutation_p.D1111H	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1078	Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCATTTCTGTGACTACACTGA	0.443000													22	87					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	52912933	52912933	+	Silent	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:52912933T>C	ENST00000373980.4	+	2	738	c.321T>C	c.(319-321)gaT>gaC	p.D107D	PRKG1_ENST00000373985.1_Silent_p.D80D|PRKG1_ENST00000401604.2_Silent_p.D92D	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	92					actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		GGTCCAAGGATCTTATAAAGG	0.458000													17	97					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208632531	208632531	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:208632531G>A	ENST00000295417.3	-	2	1486	c.933C>T	c.(931-933)ggC>ggT	p.G311G		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	311					angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		ACAGTGCAGGGCCCGTGGTCT	0.647000													3	17					0	0	1	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3857	3857	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrM:3857T>C	ENST00000361390.2	+	1	551	c.551T>C	c.(550-552)aTa>aCa	p.184_184insT						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						CTTGGCCATAATATGATTTAT	0.478000													14	6					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150531134	150531134	+	Silent	SNP	G	G	A	rs12049100	byFrequency	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:150531134G>A	ENST00000369041.5	+	15	2818	c.2568G>A	c.(2566-2568)ccG>ccA	p.P856P	ADAMTSL4_ENST00000369039.5_Intron|ADAMTSL4_ENST00000369038.2_Intron|ADAMTSL4_ENST00000271643.4_Intron	NM_025008.3	NP_079284.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	856	TSP type-1 4.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGGTGAGCCCGGAACCCCCAG	0.602000													3	36					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153038	5153038	+	Missense_Mutation	SNP	A	A	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr11:5153038A>T	ENST00000307388.1	-	1	834	c.835T>A	c.(835-837)Ttg>Atg	p.L279M		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGATTTGACAAGAGGATATGA	0.398000													20	78					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197707219	197707219	+	Missense_Mutation	SNP	G	G	A	rs138595233		TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:197707219G>A	ENST00000330198.4	+	6	594	c.572G>A	c.(571-573)gGt>gAt	p.G191D	LMLN_ENST00000420910.2_Missense_Mutation_p.G191D|LMLN_ENST00000482695.1_Missense_Mutation_p.G139D|LMLN_ENST00000332636.5_Missense_Mutation_p.G139D	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	191					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TACCGTGGGGGTAAGTGGCCT	0.512000													4	152					0	0	1	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138518	101138518	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrX:101138518C>A	ENST00000372782.3	-	7	1928	c.1881G>T	c.(1879-1881)gaG>gaT	p.E627D	ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000458570.1_Missense_Mutation_p.E456D|ZMAT1_ENST00000540921.1_Missense_Mutation_p.E627D	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	456						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						AAAGCATTTCCTCTTCTGTCC	0.338000													12	47					2.32078e-09	2.55649e-09	1	1	0
BCL2L1	598	broad.mit.edu	37	20	30309755	30309755	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:30309755C>T	ENST00000307677.4	-	2	677	c.267G>A	c.(265-267)gcG>gcA	p.A89A	BCL2L1_ENST00000420653.1_Silent_p.A89A|BCL2L1_ENST00000376062.2_Silent_p.A89A|BCL2L1_ENST00000376055.4_Silent_p.A89A	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	89					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CCTCCCTCAGCGCTTGCTTTA	0.622000													22	82					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327864	152327864	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:152327864C>A	ENST00000388718.5	-	3	2470	c.2398G>T	c.(2398-2400)Ggc>Tgc	p.G800C	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	800	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTTGAGCCTGACCCATGT	0.522000													27	341					5.8336e-16	6.6873e-16	1	1	0
OLFML1	283298	broad.mit.edu	37	11	7530992	7530992	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr11:7530992T>G	ENST00000329293.3	+	3	1176	c.782T>G	c.(781-783)gTt>gGt	p.V261G	OLFML1_ENST00000530135.1_Missense_Mutation_p.V261G|CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000528758.1_3'UTR	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	261	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CGAGCATTGGTTTACCAGCAC	0.517000													5	39					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186089	127186089	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrX:127186089G>A	ENST00000371124.3	-	1	293	c.97C>T	c.(97-99)Cat>Tat	p.H33Y		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	33						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CTGATGACATGGCGGGGTCCA	0.448000													29	36					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306626	54306626	+	Missense_Mutation	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr15:54306626A>C	ENST00000545554.1	+	1	1526	c.1526A>C	c.(1525-1527)aAa>aCa	p.K509T	UNC13C_ENST00000537900.1_Missense_Mutation_p.K509T|UNC13C_ENST00000260323.11_Missense_Mutation_p.K509T			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	509					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATTATGATAAAATCTCCTCA	0.388000													14	29					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82439275	82439275	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr8:82439275C>G	ENST00000360464.4	-	3	390	c.328G>C	c.(328-330)Gtg>Ctg	p.V110L	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	110							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						TTCCCATCCACCAGCTTTCTC	0.413000													3	25					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823271	10823271	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:10823271C>T	ENST00000250237.5	+	7	838	c.828C>T	c.(826-828)gaC>gaT	p.D276D		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	276					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TTGGATGTGACATGTTCGACT	0.642000													65	283					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													4	111					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13753262	13753262	+	Splice_Site	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:13753262C>G	ENST00000202816.1	-	5	1257		c.e5-1			NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						AAGGATATATCTAAACAGAAA	0.363000													23	62					0	0	1	0	0
GPR18	2841	broad.mit.edu	37	13	99907375	99907375	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr13:99907375C>G	ENST00000340807.3	-	3	1308	c.752G>C	c.(751-753)tGt>tCt	p.C251S	GPR18_ENST00000397473.2_Missense_Mutation_p.C251S|GPR18_ENST00000397470.2_Missense_Mutation_p.C251S|UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	251						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	GAAAGCGAAACAGATGTGGAA	0.512000													24	87					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428867	48428867	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:48428867C>T	ENST00000224605.2	-	2	1284	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	340					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CTTCTTCCTGCGGTCTTTGCG	0.662000													12	59					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985611	6985611	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr18:6985611T>A	ENST00000389658.3	-	38	5504	c.5411A>T	c.(5410-5412)aAt>aTt	p.N1804I		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1804	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAGGTCAGATTTTGTTCTTC	0.428000													19	73					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88424068	88424068	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:88424068T>A	ENST00000297203.2	-	2	374	c.189A>T	c.(187-189)aaA>aaT	p.K63N	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	63										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						CAGCAACATCTTTTCTTTCTA	0.393000													19	39					0	0	1	0	0
SLC5A6	8884	broad.mit.edu	37	2	27426143	27426143	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:27426143C>T	ENST00000310574.3	-	11	1638	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K	SLC5A6_ENST00000461319.1_5'UTR|SLC5A6_ENST00000408041.1_Missense_Mutation_p.E389K	NM_021095.2	NP_066918.2	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	389					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(3)|prostate(1)|skin(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	TCAGAGAACTCAGGGAACCAA	0.478000													16	82					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108322068	108322068	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:108322068G>A	ENST00000370056.4	-	3	642	c.368C>T	c.(367-369)gCc>gTc	p.A123V	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000371846.4_Missense_Mutation_p.A58V|VAV3_ENST00000527011.1_Missense_Mutation_p.A123V	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	123					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GATTCCTGTGGCCAATGCTAT	0.338000													16	34					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488058	24488058	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:24488058G>A	ENST00000264463.4	-	12	2588	c.2081C>T	c.(2080-2082)aCg>aTg	p.T694M	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	694					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.T694M(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AATAAATAACGTTTCTGGAAT	0.498000										HNSCC(23;0.051)			7	67					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520910	52520910	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr14:52520910G>A	ENST00000216286.5	-	4	896	c.897C>T	c.(895-897)tcC>tcT	p.S299S	NID2_ENST00000541773.1_Silent_p.S246S	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	299						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CATGGCTGAAGGAACGTCCCA	0.522000													10	31					0	0	1	0	0
RPP30	10556	broad.mit.edu	37	10	92656112	92656112	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:92656112G>A	ENST00000413330.1	+	10	695	c.660G>A	c.(658-660)gcG>gcA	p.A220A	RPP30_ENST00000489806.1_3'UTR|RPP30_ENST00000371703.3_Silent_p.A220A	NM_001104546.1	NP_001098016.1	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit	220					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	8						CCAAGGCTGCGGTGTCCACCA	0.493000													10	64					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79441545	79441545	+	Silent	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr9:79441545T>G	ENST00000376718.3	-	5	735	c.612A>C	c.(610-612)ccA>ccC	p.P204P	PRUNE2_ENST00000428286.1_5'UTR|PRUNE2_ENST00000376713.3_Silent_p.P204P	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	204					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TGTCCTCTCTTGGAGGCAAGT	0.478000													33	49					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43008794	43008794	+	Missense_Mutation	SNP	C	C	T	rs141899283	by1000genomes	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:43008794C>T	ENST00000535468.1	-	20	4003	c.3917G>A	c.(3916-3918)cGg>cAg	p.R1306Q	CUL7_ENST00000265348.3_Missense_Mutation_p.R1222Q	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1222					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding	p.R1222Q(1)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTCAATGTGCCGGGCGAACTG	0.587000													8	48					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175140	143175140	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:143175140C>T	ENST00000408916.1	+	1	175	c.175C>T	c.(175-177)Cag>Tag	p.Q59*	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	59					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CTTCTGCCTGCAGTTGGTTGG	0.567000													21	112					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27844223	27844223	+	Missense_Mutation	SNP	A	A	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:27844223A>T	ENST00000355467.4	+	14	1682	c.1599A>T	c.(1597-1599)gaA>gaT	p.E533D	ZNF512_ENST00000379717.1_Missense_Mutation_p.E532D|ZNF512_ENST00000556601.1_Intron|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000416005.2_Missense_Mutation_p.E504D|ZNF512_ENST00000413371.2_Missense_Mutation_p.E456D			Q96ME7	ZN512_HUMAN	zinc finger protein 512	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					ATAATGAGGAACTGGTAGTGT	0.517000													9	37					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36351937	36351937	+	Splice_Site	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:36351937A>C	ENST00000360202.5	+	8	1253	c.1056_splice	c.e8+1	p.Q352_splice	KIRREL2_ENST00000347900.6_Splice_Site_p.Q302_splice|KIRREL2_ENST00000262625.7_Splice_Site_p.Q352_splice|KIRREL2_ENST00000586102.2_Splice_Site_p.Q332_splice|KIRREL2_ENST00000592409.1_Splice_Site_p.Q352_splice|NPHS1_ENST00000591817.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	352	Ig-like C2-type 4.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGTGGCGCGCAGGTACAGCCC	0.677000													4	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529628	179529628	+	Silent	SNP	A	A	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:179529628A>T	ENST00000589042.1	-	166	36293	c.36069T>A	c.(36067-36069)atT>atA	p.I12023I	TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10169	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGGCAGGAATAATTTCTT	0.383000													3	9					0	0	1	0	0
HOXC12	3228	broad.mit.edu	37	12	54348901	54348901	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:54348901G>T	ENST00000243103.3	+	1	284	c.188G>T	c.(187-189)gGc>gTc	p.G63V		NM_173860.1	NP_776272.1	P31275	HXC12_HUMAN	homeobox C12	63					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	12						CCGTGCAATGGCTACCCGCAG	0.711000													3	13					0.150653	0.152821	1	1	0
GLI1	2735	broad.mit.edu	37	12	57864972	57864972	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:57864972G>A	ENST00000228682.2	+	12	2540	c.2449G>A	c.(2449-2451)Gaa>Aaa	p.E817K	GLI1_ENST00000543426.1_Missense_Mutation_p.E689K|GLI1_ENST00000546141.1_Missense_Mutation_p.E776K	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	817			E -> Q (in a breast cancer sample; somatic mutation).		epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.E817Q(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			AGTCAAGCCAGAACAGGGGTG	0.602000													16	81					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65321675	65321675	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr11:65321675G>A	ENST00000301873.5	-	2	776	c.508C>T	c.(508-510)Ccg>Tcg	p.P170S	LTBP3_ENST00000536982.1_Intron|LTBP3_ENST00000322147.4_Missense_Mutation_p.P170S	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	170						extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						GCCAGGGGCGGCAGCGCCCCT	0.746000													3	25					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131546065	131546065	+	Silent	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:131546065T>A	ENST00000401867.1	-	7	1189	c.621A>T	c.(619-621)tcA>tcT	p.S207S	P4HA2_ENST00000360568.3_Silent_p.S207S|P4HA2_ENST00000379100.2_Silent_p.S207S|P4HA2_ENST00000379104.2_Silent_p.S207S|P4HA2_ENST00000166534.4_Silent_p.S207S|P4HA2_ENST00000379086.1_Silent_p.S207S			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	207						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CCAGCACCTGTGACTTGGTTG	0.572000													32	119					0	0	1	0	0
LDLRAD1	388633	broad.mit.edu	37	1	54483100	54483100	+	Splice_Site	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:54483100C>T	ENST00000371360.1	-	2	39	c.21_splice	c.e2-1	p.G8_splice	LDLRAD1_ENST00000371362.3_Splice_Site_p.G8_splice|LDLRAD1_ENST00000545928.1_Splice_Site_p.G8_splice|LDLRAD1_ENST00000420619.1_Intron	NM_001010978.2	NP_001010978.2	Q5T700	LRAD1_HUMAN	low density lipoprotein receptor class A domain containing 1	8						integral to membrane	receptor activity			large_intestine(3)|prostate(1)|skin(3)	7						CCATTCTCTCCCTGCCCAAGA	0.592000													3	10					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:49395482G>C	ENST00000419783.1	-	1	551	c.230C>G	c.(229-231)cCg>cGg	p.P77R	GPX1_ENST00000419349.1_Missense_Mutation_p.P77R|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.726000													3	16					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6241433	6241433	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr18:6241433T>A	ENST00000400104.3	-	8	676	c.476A>T	c.(475-477)aAa>aTa	p.K159I	L3MBTL4_ENST00000284898.6_Missense_Mutation_p.K159I|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.K159I|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.K159I			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	159					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				CCAAACAAATTTATCTTTTCT	0.313000													16	84					0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110587637	110587637	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr8:110587637G>C	ENST00000399066.3	-	6	2208	c.1481C>G	c.(1480-1482)cCa>cGa	p.P494R	SYBU_ENST00000433638.1_Missense_Mutation_p.P497R|SYBU_ENST00000422135.1_Missense_Mutation_p.P497R|SYBU_ENST00000533171.1_Missense_Mutation_p.P497R|SYBU_ENST00000529175.1_Missense_Mutation_p.P291R|SYBU_ENST00000529690.1_Missense_Mutation_p.P367R|SYBU_ENST00000528331.1_Missense_Mutation_p.P378R|SYBU_ENST00000533065.1_Missense_Mutation_p.P378R|SYBU_ENST00000528647.1_Missense_Mutation_p.P496R|SYBU_ENST00000276646.9_Missense_Mutation_p.P497R|SYBU_ENST00000532779.1_Missense_Mutation_p.P429R|SYBU_ENST00000419099.1_Missense_Mutation_p.P496R|SYBU_ENST00000446070.2_Missense_Mutation_p.P496R|SYBU_ENST00000440310.1_Missense_Mutation_p.P497R|SYBU_ENST00000408889.3_Missense_Mutation_p.P378R|SYBU_ENST00000424158.2_Missense_Mutation_p.P502R|SYBU_ENST00000408908.2_Missense_Mutation_p.P497R|SYBU_ENST00000533895.1_Missense_Mutation_p.P496R	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	497						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						TGAGATGGCTGGGCTGTAGGG	0.617000													10	55					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156280403	156280403	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:156280403C>T	ENST00000295688.3	-	13	1759	c.1479G>A	c.(1477-1479)ctG>ctA	p.L493L	CCT3_ENST00000368261.3_Silent_p.L448L|CCT3_ENST00000368259.2_Silent_p.L455L|CCT3_ENST00000472765.2_Silent_p.L448L	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	493					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CCCATATGCCCAGTTCCTTCA	0.458000													12	25					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51863545	51863545	+	Silent	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:51863545G>T	ENST00000453097.2	+	12	1714	c.1497G>T	c.(1495-1497)ctG>ctT	p.L499L	SLC4A8_ENST00000535225.2_Silent_p.L446L|SLC4A8_ENST00000394856.1_Silent_p.L446L|SLC4A8_ENST00000358657.3_Silent_p.L526L|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000514353.3_Silent_p.L446L	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	499					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTGGGGGACTGCTTGGAGAAG	0.498000													31	131					9.04072e-19	1.06228e-18	1	1	0
SNAPC4	6621	broad.mit.edu	37	9	139275266	139275266	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr9:139275266C>A	ENST00000298532.2	-	19	2793	c.2425G>T	c.(2425-2427)Gtc>Ttc	p.V809F		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	809					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.V809I(1)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CTCTCTCGGACGACCTCCAAG	0.622000													3	80					0.184627	0.185946	1	1	0
LMO7	4008	broad.mit.edu	37	13	76395684	76395684	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr13:76395684T>G	ENST00000357063.3	+	15	3995	c.2735T>G	c.(2734-2736)gTc>gGc	p.V912G	LMO7_ENST00000465261.2_Missense_Mutation_p.V627G|LMO7_ENST00000341547.4_Missense_Mutation_p.V578G|LMO7_ENST00000526202.1_Missense_Mutation_p.V477G|LMO7_ENST00000377534.3_Missense_Mutation_p.V912G|LMO7_ENST00000321797.8_Missense_Mutation_p.V627G			Q8WWI1	LMO7_HUMAN	LIM domain 7	912						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ACATCTGTGGTCACACCAAGA	0.458000													11	21					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13493	13493	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chrM:13493T>C	ENST00000361567.2	+	1	1157	c.1157T>C	c.(1156-1158)cTc>cCc	p.L386P				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	386					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	AATACCTTTCCTCACAGGTTT	0.448000													21	13					0	0	1	0	0
TAAR1	134864	broad.mit.edu	37	6	132967043	132967043	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:132967043T>C	ENST00000275216.1	-	1	99	c.100A>G	c.(100-102)Att>Gtt	p.I34V		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	34						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	GTGGTCAGAATTATGAGCACC	0.383000													7	267					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131306394	131306394	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:131306394C>A	ENST00000512055.1	-	12	2840	c.714G>T	c.(712-714)aaG>aaT	p.K238N	CPNE4_ENST00000511604.1_Missense_Mutation_p.K238N|CPNE4_ENST00000429747.1_Missense_Mutation_p.K238N|CPNE4_ENST00000502818.1_Missense_Mutation_p.K256N|CPNE4_ENST00000512332.1_Missense_Mutation_p.K256N			Q96A23	CPNE4_HUMAN	copine IV	238	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TGAAGTCATGCTTGCCATTGG	0.428000													4	103					0.0215528	0.022182	1	1	0
RECQL5	9400	broad.mit.edu	37	17	73627675	73627675	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:73627675G>T	ENST00000317905.5	-	9	1462	c.1303C>A	c.(1303-1305)Cag>Aag	p.Q435K	RECQL5_ENST00000423245.2_Missense_Mutation_p.Q408K|RECQL5_ENST00000443199.2_5'UTR	NM_004259.6	NP_004250.4	O94762	RECQ5_HUMAN	RecQ protein-like 5	435					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GTGGGGTTCTGGCAGTGGTCG	0.687000								Other identified genes with known or suspected DNA repair function					13	72					4.93089e-13	5.47445e-13	1	1	0
TCF7L1	83439	broad.mit.edu	37	2	85531118	85531118	+	Silent	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:85531118A>C	ENST00000282111.3	+	6	1034	c.759A>C	c.(757-759)ccA>ccC	p.P253P		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	253	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						GGCTCGTCCCACAGTAAGGAA	0.667000													26	81					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26392855	26392855	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:26392855C>T	ENST00000374272.3	-	2	374	c.236G>A	c.(235-237)cGc>cAc	p.R79H	TRIM63_ENST00000483052.1_5'UTR	NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	79	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CACCTCGTGGCGGCAGGTGGG	0.602000													13	45					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138635035	138635035	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:138635035A>G	ENST00000251691.4	+	26	4470	c.4304A>G	c.(4303-4305)gAt>gGt	p.D1435G		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1435					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGCAGTGAGGATGGAATTGAA	0.438000													8	30					0	0	1	0	0
FAM114A2	10827	broad.mit.edu	37	5	153382414	153382414	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:153382414G>A	ENST00000351797.4	-	10	1185	c.1109C>T	c.(1108-1110)tCa>tTa	p.S370L	FAM114A2_ENST00000520667.1_Missense_Mutation_p.S370L|FAM114A2_ENST00000520313.1_Missense_Mutation_p.S300L|FAM114A2_ENST00000522858.1_Missense_Mutation_p.S370L	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	370							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						TACCTCTATTGAATTTTTGTT	0.403000													29	184					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39127875	39127875	+	Nonsense_Mutation	SNP	A	A	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:39127875A>C	ENST00000351578.6	-	11	2065	c.1875T>G	c.(1873-1875)taT>taG	p.Y625*	FYB_ENST00000515010.1_Nonsense_Mutation_p.Y625*|FYB_ENST00000505428.1_Nonsense_Mutation_p.Y625*|FYB_ENST00000540520.1_Nonsense_Mutation_p.Y635*|FYB_ENST00000512982.1_Nonsense_Mutation_p.Y625*	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	625					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			CAATCCCATCATAAATGTCAT	0.338000													8	46					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113652451	113652451	+	Missense_Mutation	SNP	G	G	A	rs148051584	by1000genomes	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:113652451G>A	ENST00000358160.4	+	12	1795	c.1303G>A	c.(1303-1305)Gtg>Atg	p.V435M	GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000472026.1_Missense_Mutation_p.V268M|GRAMD1C_ENST00000452134.2_Missense_Mutation_p.V164M|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.V230M	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	435						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						CTTCTATACCGTGAACAGATA	0.408000													4	153					0	0	1	0	0
CCDC173	129881	broad.mit.edu	37	2	170531188	170531188	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:170531188T>C	ENST00000447353.1	-	4	665	c.560A>G	c.(559-561)gAa>gGa	p.E187G		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		TTTCAACTGTTCCTCCCATTT	0.358000													7	9					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701254	143701254	+	Silent	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:143701254G>T	ENST00000408922.2	+	1	233	c.165G>T	c.(163-165)ctG>ctT	p.L55L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					ATCGGCCACTGCACAAGCCTA	0.473000													18	35					5.35267e-07	5.71762e-07	1	1	0
PLEKHH3	79990	broad.mit.edu	37	17	40820225	40820225	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:40820225C>G	ENST00000293349.6	-	13	2723	c.2293G>C	c.(2293-2295)Gac>Cac	p.D765H	PLEKHH3_ENST00000412503.1_Missense_Mutation_p.D591H|PLEKHH3_ENST00000456950.2_5'UTR|PLEKHH3_ENST00000591022.1_Missense_Mutation_p.D768H			Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	768					signal transduction	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|skin(2)	13		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GGGGAGGTGTCTGGCAGGTCT	0.647000													8	19					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7586010	7586010	+	Silent	SNP	A	A	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:7586010A>G	ENST00000313599.3	-	3	462	c.405T>C	c.(403-405)caT>caC	p.H135H	CD163L1_ENST00000396630.1_Silent_p.H135H|CD163L1_ENST00000416109.2_Silent_p.H135H			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	135	SRCR 1.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GATAACAGTTATGGCTTCCCC	0.443000													33	126					0	0	1	0	0
DESI2	51029	broad.mit.edu	37	1	244852580	244852580	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:244852580T>C	ENST00000302550.11	+	3	524	c.145T>C	c.(145-147)Ttt>Ctt	p.F49L	DESI2_ENST00000263831.7_Intron	NM_016076.3	NP_057160.2	Q9BSY9	PPDE1_HUMAN	desumoylating isopeptidase 2	49	PPPDE peptidase.																TCCTTACCCCTTTTCTGGAAT	0.313000													4	188					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16900066	16900066	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:16900066C>T	ENST00000502640.1	-	1	191	c.43G>A	c.(43-45)Ggc>Agc	p.G15S	LDB2_ENST00000441778.2_Missense_Mutation_p.G15S|LDB2_ENST00000515064.1_Missense_Mutation_p.G15S|LDB2_ENST00000304523.5_Missense_Mutation_p.G15S			O43679	LDB2_HUMAN	LIM domain binding 2	15							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						TAAAATGGGCCGAAAGGAGAA	0.458000													14	48					0	0	1	0	0
MLX	6945	broad.mit.edu	37	17	40722187	40722187	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:40722187C>G	ENST00000246912.4	+	7	879	c.826C>G	c.(826-828)Cac>Gac	p.H276D	MLX_ENST00000435881.2_Missense_Mutation_p.H222D|MLX_ENST00000346833.4_Missense_Mutation_p.H192D	NM_170607.2	NP_733752.1	Q9UH92	MLX_HUMAN	MLX, MAX dimerization protein	276					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			kidney(3)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	10		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		GATCGAGGAGCACTGTAAGCC	0.532000													10	41					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602110	61602110	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr18:61602110G>C	ENST00000238508.3	+	8	887	c.828G>C	c.(826-828)tgG>tgC	p.W276C	AC009802.1_ENST00000599868.1_Intron	NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TGAATGAGTGGACCAGTGCAG	0.443000													15	64					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122873884	122873884	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:122873884G>A	ENST00000316218.7	+	15	1435	c.1340G>A	c.(1339-1341)cGa>cAa	p.R447Q	PDIA5_ENST00000467157.1_3'UTR	NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	447	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		AAAGATGACCGAAAGGTAAGG	0.512000													4	143					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57905595	57905595	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:57905595A>G	ENST00000262027.5	+	12	1617	c.1483A>G	c.(1483-1485)Ata>Gta	p.I495V	MARS_ENST00000447721.2_3'UTR|MARS_ENST00000315473.5_Missense_Mutation_p.I261V	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	495					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	GCCACGCTGCATAACCCGAGA	0.498000													9	30					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12541141	12541141	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:12541141C>T	ENST00000301547.5	-	4	2042	c.1845G>A	c.(1843-1845)ccG>ccA	p.P615P	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	615					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						TACATTCATACGGGTTCTCTC	0.403000													4	79					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169781240	169781240	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:169781240C>T	ENST00000263817.6	-	27	3816	c.3692G>A	c.(3691-3693)cGg>cAg	p.R1231Q		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1231	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TACAATGGCCCGAGCAATAGC	0.403000													22	68					0	0	1	0	0
MB21D2	151963	broad.mit.edu	37	3	192517350	192517350	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:192517350C>A	ENST00000392452.2	-	2	621	c.301G>T	c.(301-303)Gac>Tac	p.D101Y		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	101										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						TCATCTAAGTCCAGGTCCACC	0.502000													12	62					2.27111e-07	2.44448e-07	1	1	0
CCM2	83605	broad.mit.edu	37	7	45104153	45104153	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:45104153G>A	ENST00000381112.3	+	4	1122	c.443G>A	c.(442-444)gGg>gAg	p.G148E	CCM2_ENST00000461377.1_3'UTR|CCM2_ENST00000258781.6_Missense_Mutation_p.G127E|CCM2_ENST00000541586.1_Missense_Mutation_p.G69E|CCM2_ENST00000474617.1_Missense_Mutation_p.G121E|CCM2_ENST00000544363.1_Missense_Mutation_p.G127E|CCM2_ENST00000475551.1_Missense_Mutation_p.G121E	NM_001029835.2	NP_001025006.1	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	127	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						TGGAGGGACGGGGAGGATATC	0.597000													15	35					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190039	53190039	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr16:53190039A>G	ENST00000566029.1	+	2	247	c.38A>G	c.(37-39)aAt>aGt	p.N13S	CHD9_ENST00000398510.3_Missense_Mutation_p.N13S|CHD9_ENST00000564845.1_Missense_Mutation_p.N13S|CHD9_ENST00000447540.1_Missense_Mutation_p.N13S			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	13					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GATGATGCCAATCTTTTTGGT	0.378000													5	36					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32811893	32811893	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr13:32811893C>T	ENST00000380250.3	+	44	6684	c.6188C>T	c.(6187-6189)gCc>gTc	p.A2063V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2063					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TACTTAATGGCCTTAAGGCTG	0.502000													17	28					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344313	248344313	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:248344313G>C	ENST00000359682.2	+	1	1026	c.1026G>C	c.(1024-1026)ttG>ttC	p.L342F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	342					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACTAGCATTGATTATGTACA	0.274000													50	106					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115335696	115335696	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:115335696C>A	ENST00000351270.3	+	4	360	c.264C>A	c.(262-264)tgC>tgA	p.C88*	HABP2_ENST00000537906.1_Missense_Mutation_p.A77D|HABP2_ENST00000542051.1_Nonsense_Mutation_p.C62*|HABP2_ENST00000541666.1_Nonsense_Mutation_p.C88*	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	88	EGF-like 1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GTGGGGACTGCCTCGTCCATG	0.557000													75	230					1.40862e-40	1.69757e-40	1	1	0
SNRPG	6637	broad.mit.edu	37	2	70516505	70516505	+	Splice_Site	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:70516505C>G	ENST00000482975.2	-	2	764		c.e2-1		SNRPG_ENST00000272348.2_Splice_Site|SNRPG_ENST00000449935.2_Splice_Site|SNRPG_ENST00000438261.1_Splice_Site|SNRPG_ENST00000413456.2_Splice_Site|SNRPG_ENST00000454893.1_Splice_Site|SNRPG_ENST00000429728.1_Intron			P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G						histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			endometrium(1)	1						GTCCATAAATCTGAAAAAGGA	0.244000													2	5					0	0	1	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273310	145273310	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:145273310C>T	ENST00000369340.3	+	4	608	c.164C>T	c.(163-165)tCa>tTa	p.S55L	NOTCH2NL_ENST00000344859.3_Missense_Mutation_p.S55L|NOTCH2NL_ENST00000362074.6_Missense_Mutation_p.S55L|RP11-458D21.5_ENST00000468030.1_Missense_Mutation_p.S55L			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	55	EGF-like 2.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						CGATGTGCCTCAGGGTTTACA	0.562000													27	493					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863200	85863200	+	Missense_Mutation	SNP	T	T	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr9:85863200T>C	ENST00000304195.3	-	14	1633	c.1427A>G	c.(1426-1428)gAa>gGa	p.E476G	FRMD3_ENST00000328788.1_Missense_Mutation_p.E133G|FRMD3_ENST00000376434.1_Missense_Mutation_p.E282G|FRMD3_ENST00000376438.1_Missense_Mutation_p.E476G|FRMD3_ENST00000465485.1_5'UTR	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	476						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						GTCTTCTCTTTCCAACTCAAG	0.493000													51	113					0	0	1	0	0
PTX3	5806	broad.mit.edu	37	3	157155312	157155312	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr3:157155312C>T	ENST00000295927.3	+	2	286	c.141C>T	c.(139-141)tgC>tgT	p.C47C	VEPH1_ENST00000362010.2_Intron|VEPH1_ENST00000392833.2_Intron|VEPH1_ENST00000392832.2_Intron|VEPH1_ENST00000543418.1_Intron	NM_002852.3	NP_002843.2	P26022	PTX3_HUMAN	pentraxin 3, long	47					inflammatory response	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)	10			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CCACGCCGTGCGCCTGCGGTC	0.602000													3	29					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170178	32170178	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:32170178C>G	ENST00000375023.3	-	21	3568	c.3430G>C	c.(3430-3432)Ggc>Cgc	p.G1144R		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1144	EGF-like 29.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GAGCAGCTGCCATTGTATAGG	0.657000													4	19					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140300008	140300008	+	Splice_Site	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:140300008G>C	ENST00000296543.5	+	17	2478	c.2155_splice	c.e17+1	p.A719_splice	NAA15_ENST00000398947.1_Splice_Site_p.V719_splice	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	719					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						CTTTAATACTGGTATGTTTTT	0.333000													14	61					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140300009	140300009	+	Splice_Site	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:140300009G>T	ENST00000296543.5	+	17	2478		c.e17+1		NAA15_ENST00000398947.1_Splice_Site	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTTAATACTGGTATGTTTTTG	0.338000													14	60					2.37509e-13	2.65784e-13	1	1	0
LYST	1130	broad.mit.edu	37	1	235840796	235840796	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:235840796T>G	ENST00000389794.3	-	49	11098	c.10924A>C	c.(10924-10926)Ata>Cta	p.I3642L	LYST_ENST00000473037.1_5'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.I3642L			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3642					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAATCCCATATGATGCAGGTT	0.328000													13	136					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34514436	34514436	+	Silent	SNP	C	C	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr9:34514436C>A	ENST00000242317.4	+	17	1785	c.1614C>A	c.(1612-1614)gcC>gcA	p.A538A		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	538					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		CCTATGACGCCCACAACATGT	0.552000									Kartagener syndrome				43	123					3.19069e-20	3.78056e-20	1	1	0
PPP1R14C	81706	broad.mit.edu	37	6	150569944	150569944	+	Silent	SNP	G	G	A			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:150569944G>A	ENST00000361131.4	+	4	603	c.486G>A	c.(484-486)aaG>aaA	p.K162K		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	162					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		CTCCGCAGAAGAAGAGTGTAT	0.423000													9	36					0	0	1	0	0
SPPL2A	84888	broad.mit.edu	37	15	51041856	51041856	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr15:51041856G>C	ENST00000261854.5	-	2	428	c.154C>G	c.(154-156)Ctt>Gtt	p.L52V	RP11-507J18.2_ENST00000558317.1_RNA	NM_032802.3	NP_116191.2	Q8TCT8	PSL2_HUMAN	signal peptide peptidase like 2A	52						integral to membrane	aspartic-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		GTACTTGGAAGAGCTGTCCAA	0.443000													41	137					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579373	7579373	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr17:7579373C>T	ENST00000420246.2	-	4	446	c.314G>A	c.(313-315)gGc>gAc	p.G105D	TP53_ENST00000455263.2_Missense_Mutation_p.G105D|TP53_ENST00000269305.4_Missense_Mutation_p.G105D|TP53_ENST00000413465.2_Missense_Mutation_p.G105D|TP53_ENST00000445888.2_Missense_Mutation_p.G105D|TP53_ENST00000359597.4_Missense_Mutation_p.G105D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	105	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in a sporadic cancer; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G105D(4)|p.Q100fs*37(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G105A(1)|p.G105V(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCGTAGCTGCCCTGGTAGGT	0.622000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	45					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45188667	45188667	+	Silent	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr20:45188667G>T	ENST00000279027.4	-	13	1821	c.1803C>A	c.(1801-1803)acC>acA	p.T601T	SLC13A3_ENST00000472148.1_Silent_p.T519T|SLC13A3_ENST00000495082.1_Silent_p.T554T|SLC13A3_ENST00000435032.1_Silent_p.T186T|SLC13A3_ENST00000413164.2_Silent_p.T551T|SLC13A3_ENST00000290317.5_Silent_p.T554T|SLC13A3_ENST00000396360.1_Silent_p.T519T	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	601						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GGACTCAGAGGGTCCGAAATG	0.527000													20	84					6.21321e-17	7.24019e-17	1	1	0
RUNX1T1	862	broad.mit.edu	37	8	92988173	92988173	+	Silent	SNP	A	A	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr8:92988173A>T	ENST00000523629.1	-	10	1762	c.1308T>A	c.(1306-1308)ccT>ccA	p.P436P	RUNX1T1_ENST00000422361.2_Silent_p.P399P|RUNX1T1_ENST00000265814.3_Silent_p.P436P|RUNX1T1_ENST00000518844.1_Silent_p.P409P|RUNX1T1_ENST00000360348.2_Silent_p.P399P|RUNX1T1_ENST00000436581.2_Silent_p.P447P|RUNX1T1_ENST00000396218.1_Silent_p.P409P|RUNX1T1_ENST00000520724.1_Silent_p.P399P|GS1-5L10.1_ENST00000522980.1_RNA	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	436					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ATCCAGACGCAGGCCTGTGAA	0.488000													32	155					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	175995996	175995996	+	Silent	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:175995996C>T	ENST00000510636.1	+	5	574	c.300C>T	c.(298-300)agC>agT	p.S100S	CDHR2_ENST00000261944.5_Silent_p.S100S|CDHR2_ENST00000506348.1_Silent_p.S100S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	100	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TCTCCGTGAGCGACCCCTACA	0.632000													15	127					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51217526	51217526	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr19:51217526C>T	ENST00000293441.1	-	4	571	c.553G>A	c.(553-555)Gag>Aag	p.E185K	SHANK1_ENST00000391814.1_Missense_Mutation_p.E185K|SHANK1_ENST00000359082.3_Missense_Mutation_p.E185K	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	185					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGCACATACTCCAGGAACTTC	0.592000													12	43					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186680101	186680101	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr2:186680101G>T	ENST00000343098.5	+	19	20596	c.20596G>T	c.(20596-20598)Gaa>Taa	p.E6866*	FSIP2_ENST00000424728.1_Nonsense_Mutation_p.E6777*	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TTTCCAGAAAGAAGAAAAGAA	0.318000													8	37					0.0477658	0.0488041	1	1	0
RPTN	126638	broad.mit.edu	37	1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr1:152127881_152127884delTGTC	ENST00000316073.3	-	3	1755_1758	c.1691_1694delGACA	c.(1690-1695)aafs	p.RQ564fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	564	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GCTCTGGCCTTGTCTGTCTGTCTG	0.485													7	1247	---	---	---	---					
C4orf21	55345	broad.mit.edu	37	4	113527178	113527178	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr4:113527178delT	ENST00000505019.1	-	9	2913	c.2788delA	c.(2788-2790)ccfs	p.T930fs	C4orf21_ENST00000309071.5_Frame_Shift_Del_p.T930fs	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	930										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GGGTCACAGGTTTTTCTCTCT	0.299													39	110	---	---	---	---					
PAPD7	11044	broad.mit.edu	37	5	6755013	6755014	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr5:6755013_6755014delAC	ENST00000230859.6	+	13	1713_1714	c.1584_1585delAC	c.(1582-1587)aaacfs	p.KH528fs		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	528					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGAGGAAAAAACACACACACAC	0.653													9	175	---	---	---	---					
FYN	2534	broad.mit.edu	37	6	111983042	111983042	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr6:111983042delT	ENST00000354650.3	-	14	2120	c.1514delA	c.(1513-1515)agfs	p.K505fs	FYN_ENST00000229471.4_Frame_Shift_Del_p.K450fs|FYN_ENST00000368678.4_Frame_Shift_Del_p.K502fs|FYN_ENST00000229470.5_Frame_Shift_Del_p.K453fs|FYN_ENST00000356013.2_Frame_Shift_Del_p.K450fs|FYN_ENST00000368667.2_Frame_Shift_Del_p.K505fs|FYN_ENST00000368682.3_Frame_Shift_Del_p.K502fs|FYN_ENST00000538466.1_Frame_Shift_Del_p.K502fs	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	505	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAGGGTCCTTTTTCCAGCA	0.562													8	298	---	---	---	---					
LRRC17	10234	broad.mit.edu	37	7	102585036	102585036	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:102585036delA	ENST00000339431.4	+	4	1603	c.1308delA	c.(1306-1308)atfs	p.I437fs	FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000456695.1_Intron|LRRC17_ENST00000249377.4_3'UTR|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000379305.3_Intron|LRRC17_ENST00000485478.1_3'UTR	NM_001031692.2	NP_001026862.1	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	437					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						AAAGCGTAATAATTACTATAG	0.318													13	35	---	---	---	---					
OR9A4	130075	broad.mit.edu	37	7	141619203	141619203	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr7:141619203delT	ENST00000548136.1	+	1	587	c.528delT	c.(526-528)aafs	p.N176fs	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TGGTGAACAATTTTTTTTGTG	0.383													8	259	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1197216	1197217	+	RNA	INS	-	-	G	rs66848317	by1000genomes	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr8:1197216_1197217insG	ENST00000517950.1	-	0	278																											GAGATCAGTGTGGAGTGATGGT	0.584													2	4	---	---	---	---					
ZNF365	22891	broad.mit.edu	37	10	64136459	64136464	+	In_Frame_Del	DEL	TGAGGC	TGAGGC	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr10:64136459_64136464delTGAGGC	ENST00000395254.3	+	2	787_792	c.507_512delTGAGGC	c.(505-513)gtt>gt	p.VEA169del	ZNF365_ENST00000410046.3_In_Frame_Del_p.VEA169del|ZNF365_ENST00000395255.3_In_Frame_Del_p.VEA169del|ZNF365_ENST00000466727.1_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					ATCGAATGGTTGAGGCTGTGGATAGG	0.505													30	135	---	---	---	---					
IGHMBP2	3508	broad.mit.edu	37	11	68703838	68703851	+	Frame_Shift_Del	DEL	CACACAGCATGGGG	CACACAGCATGGGG	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr11:68703838_68703851delCACACAGCATGGGG	ENST00000255078.3	+	13	2001_2014	c.1890_1903delCACACAGCATGGGG	c.(1888-1905)ttaafs	p.FTQHGE630fs		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	630					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding	p.G634V(2)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGGAGTATTTCACACAGCATGGGGAAGTACGCAC	0.551													27	353	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711145	6711147	+	In_Frame_Del	DEL	TCC	TCC	-	rs71584865	byFrequency	TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr12:6711145_6711147delTCC	ENST00000309577.6	-	4	580_582	c.417_419delGGA	c.(415-420)gat>ga	p.ED139del	CHD4_ENST00000544484.1_In_Frame_Del_p.ED136del|CHD4_ENST00000357008.2_In_Frame_Del_p.ED139del|CHD4_ENST00000544040.1_In_Frame_Del_p.ED132del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	139	Poly-Asp.		E -> D (in dbSNP:rs1639122).		chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCATCATCAtcctcctcctcct	0.453													8	60	---	---	---	---					
GPR18	2841	broad.mit.edu	37	13	99907848	99907848	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr13:99907848delG	ENST00000340807.3	-	3	835	c.279delC	c.(277-279)ttfs	p.F93fs	GPR18_ENST00000397470.2_Frame_Shift_Del_p.F93fs|GPR18_ENST00000397473.2_Frame_Shift_Del_p.F93fs|UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	93						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	GAATCTGGCAGAAGTACTCTC	0.388													20	52	---	---	---	---					
ZNF106	64397	broad.mit.edu	37	15	42731878	42731878	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr15:42731878delT	ENST00000263805.4	-	8	4154	c.3828delA	c.(3826-3828)agfs	p.R1276fs	ZNF106_ENST00000565611.1_Frame_Shift_Del_p.R461fs|ZNF106_ENST00000565380.1_Frame_Shift_Del_p.R504fs	NM_022473.1	NP_071918.1			zinc finger protein 106																		GAGAGTTTTCTCTGTTTCTGG	0.438													34	72	---	---	---	---					
CMTM1	113540	broad.mit.edu	37	16	66603930	66603930	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr16:66603930delT	ENST00000379500.2	+	2	591	c.524delT	c.(523-525)gtfs	p.V175fs	CMTM1_ENST00000332695.7_Intron|CMTM1_ENST00000533953.1_Intron|CKLF-CMTM1_ENST00000527729.1_Intron|CMTM1_ENST00000533666.1_Intron|CMTM1_ENST00000457188.2_Frame_Shift_Del_p.V58fs|CMTM1_ENST00000531885.1_Intron|CMTM1_ENST00000336328.6_Intron|CMTM1_ENST00000528324.1_Frame_Shift_Del_p.V58fs|CMTM1_ENST00000328020.6_Frame_Shift_Del_p.V175fs|CMTM1_ENST00000535705.1_Intron	NM_052999.3|NM_181268.2	NP_443725.3|NP_851785.2	Q8IZ96	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain containing 1	58					chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		TGCATTGTCGTTTTTTTTATT	0.348													7	213	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112402	112405	+	RNA	DEL	AACC	AACC	-	rs113232824		TCGA-95-8039-01A-11D-2238-08	TCGA-95-8039-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d08a0721-236a-4176-9ae3-86cc5135f20a	3bf683f1-e3ba-443a-9dbf-43718d4fca4e	g.chr18:112402_112405delAACC	ENST00000576266.1	+	0	36_39																											CCCTGCCCCGAACCACCCGACCCC	0.711													2	4	---	---	---	---					
