Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYVN1	84447	broad.mit.edu	37	11	64900484	64900484	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:64900484C>T	ENST00000526060.1	-	4	479	c.287G>A	c.(286-288)cGg>cAg	p.R96Q	SYVN1_ENST00000307289.6_Missense_Mutation_p.R96Q|SYVN1_ENST00000294256.8_Missense_Mutation_p.R96Q|SYVN1_ENST00000377190.3_Missense_Mutation_p.R96Q			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin	96					ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding	p.R96L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						GAAGTCATCCCGAAAAACGGT	0.522000													26	65					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104135132	104135132	+	Missense_Mutation	SNP	G	G	A	rs141665490		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr10:104135132G>A	ENST00000369983.3	+	30	3934	c.3674G>A	c.(3673-3675)cGc>cAc	p.R1225H		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1225					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTCTCCCTGCGCATTTTGCTA	0.577000													4	145					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134019889	134019889	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr9:134019889C>T	ENST00000359428.5	+	12	1661	c.1517C>T	c.(1516-1518)tCc>tTc	p.S506F	RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.S506F|RP11-544A12.4_ENST00000588378.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.S506F|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	506	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCCAGTGGCTCCGACAGCTCC	0.582000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								63	226					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310294	24310294	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:24310294T>G	ENST00000357002.4	+	4	1607	c.1492T>G	c.(1492-1494)Tct>Gct	p.S498A	ZNF254_ENST00000342944.6_Missense_Mutation_p.S413A	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	498					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408000													4	165					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175067639	175067639	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:175067639C>T	ENST00000239462.4	+	9	2140	c.2027C>T	c.(2026-2028)aCa>aTa	p.T676I		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	676	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACAGTCCTGACAGGCCTGAGA	0.622000													14	157					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578272	7578272	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:7578272G>T	ENST00000420246.2	-	6	709	c.577C>A	c.(577-579)Cat>Aat	p.H193N	TP53_ENST00000269305.4_Missense_Mutation_p.H193N|TP53_ENST00000359597.4_Missense_Mutation_p.H193N|TP53_ENST00000413465.2_Missense_Mutation_p.H193N|TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.H193N|TP53_ENST00000455263.2_Missense_Mutation_p.H193N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193Y(29)|p.H193D(13)|p.0?(8)|p.?(6)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.H61D(2)|p.H100D(2)|p.P191fs*15(1)|p.H61Y(1)|p.P191fs*6(1)|p.H100Y(1)|p.P98_E105>Q(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	57					3.6726e-16	4.25484e-16	1	1	0
MIR1261	100302228	broad.mit.edu	37	11	90602322	90602322	+	RNA	SNP	G	G	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:90602322G>T	ENST00000408659.1	-	0	48					NR_031663.1																						catctggatagaacagatcaa	0.408000													16	90					6.49762e-13	7.3485e-13	1	1	0
HSD17B7	51478	broad.mit.edu	37	1	162769603	162769603	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:162769603G>A	ENST00000367917.3	+	5	586	c.518G>A	c.(517-519)aGt>aAt	p.S173N	HSD17B7_ENST00000254521.3_Missense_Mutation_p.S173N|HSD17B7_ENST00000485405.1_3'UTR			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	173					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity	p.S173N(4)		endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TCATCTCGCAGTGCAAGGAAA	0.458000													4	96					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48641528	48641528	+	Silent	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr8:48641528G>A	ENST00000297423.4	+	18	2853	c.2469G>A	c.(2467-2469)gtG>gtA	p.V823V	SPIDR_ENST00000518074.1_Silent_p.V763V|SPIDR_ENST00000541342.1_Silent_p.V753V|SPIDR_ENST00000517693.1_Silent_p.V298V|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518060.1_Silent_p.V25V	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		GCTCCCGGGTGGTCACATCTC	0.587000													36	132					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158505188	158505188	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:158505188C>A	ENST00000355585.4	+	22	3265	c.3190C>A	c.(3190-3192)Cag>Aag	p.Q1064K	SYNJ2_ENST00000367121.3_Missense_Mutation_p.Q1064K|SYNJ2_ENST00000367112.1_Missense_Mutation_p.Q149K|SYNJ2_ENST00000367122.2_Missense_Mutation_p.Q1064K	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1064							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CAAAAAGAAGCAGCATCCAAC	0.557000													40	373					6.5261e-18	7.74975e-18	1	1	0
HIST1H3C	8352	broad.mit.edu	37	6	26045786	26045786	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:26045786C>T	ENST00000540144.1	+	1	148	c.148C>T	c.(148-150)Cgc>Tgc	p.R50C		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	50					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						CGTGGCCTTGCGCGAAATCCG	0.627000													4	205					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110765478	110765478	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:110765478C>A	ENST00000395494.2	+	7	1233	c.670C>A	c.(670-672)Caa>Aaa	p.Q224K	ATP2A2_ENST00000308664.6_Missense_Mutation_p.Q251K|ATP2A2_ENST00000539276.2_Missense_Mutation_p.Q251K			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	251					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						ACCCCTTCAGCAAAAACTAGA	0.453000													22	340					3.10358e-05	3.31281e-05	1	1	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:124857495A>C	ENST00000529051.1	+	8	1632	c.1373A>C	c.(1372-1374)cAc>cCc	p.H458P	CCDC15_ENST00000344762.5_Missense_Mutation_p.H458P			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418000													4	261					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49696554	49696554	+	Silent	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:49696554G>A	ENST00000433368.2	-	8	765	c.696C>T	c.(694-696)taC>taT	p.Y232Y	CRISP3_ENST00000263045.4_Silent_p.Y222Y|CRISP3_ENST00000423399.2_Silent_p.Y119Y|CRISP3_ENST00000393666.1_Silent_p.Y209Y|CRISP3_ENST00000371159.4_Silent_p.Y240Y	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	209					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AGAGATCTTCGTACTTGCAAC	0.358000													23	132					0	0	1	0	0
HPDL	84842	broad.mit.edu	37	1	45793481	45793481	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:45793481C>T	ENST00000334815.3	+	1	937	c.661C>T	c.(661-663)Ccg>Tcg	p.P221S		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	221					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					GCAGGCCCAGCCGGGCAGCAT	0.662000													4	168					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212431	26212431	+	Silent	SNP	G	G	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chrX:26212431G>T	ENST00000379034.1	+	2	617	c.468G>T	c.(466-468)tcG>tcT	p.S156S		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	156	Ser-rich.							p.S156S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CCACTGGCTCGCCTGATGCAG	0.507000													4	158					0.150653	0.153893	1	1	0
GCN1L1	10985	broad.mit.edu	37	12	120572490	120572490	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:120572490G>A	ENST00000300648.6	-	52	7061	c.7049C>T	c.(7048-7050)aCc>aTc	p.T2350I		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2350					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGAAAGTGGTCTGCAGCTG	0.582000													26	114					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785235	22785235	+	RNA	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:22785235C>A	ENST00000600260.1	+	0	1411					NR_033899.1																						CCAGAGGCAGCAGCCCCAGCC	0.677000													6	24					8.12818e-05	8.57975e-05	1	1	0
SMARCA4	6597	broad.mit.edu	37	19	11144113	11144113	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:11144113G>A	ENST00000358026.2	+	26	3978	c.3694G>A	c.(3694-3696)Ggc>Agc	p.G1232S	SMARCA4_ENST00000590574.1_Missense_Mutation_p.G1232S|SMARCA4_ENST00000429416.3_Missense_Mutation_p.G1232S|SMARCA4_ENST00000541122.2_Missense_Mutation_p.G1232S|SMARCA4_ENST00000589677.1_Missense_Mutation_p.G1232S|SMARCA4_ENST00000450717.3_Missense_Mutation_p.G1232S|SMARCA4_ENST00000413806.3_Missense_Mutation_p.G1232S|SMARCA4_ENST00000444061.3_Missense_Mutation_p.G1232S|SMARCA4_ENST00000344626.4_Missense_Mutation_p.G1232S	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1232	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.G1232S(5)|p.G1232C(1)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GATCCAGGCCGGCATGTTCGA	0.637000			"""F, N, Mis"""		NSCLC								55	347					0	0	1	0	0
TBRG4	9238	broad.mit.edu	37	7	45142000	45142000	+	Silent	SNP	G	G	T	rs143508956		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr7:45142000G>T	ENST00000258770.3	-	7	1388	c.1267C>A	c.(1267-1269)Cgg>Agg	p.R423R	TBRG4_ENST00000395655.4_Silent_p.R313R|TBRG4_ENST00000494076.1_Silent_p.R423R|TBRG4_ENST00000361278.3_Silent_p.R313R	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	423					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						TCTGCTTCCCGTGCCTGCTGC	0.612000													4	145					0.150653	0.153893	1	1	0
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													6	469					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368296	74368296	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr15:74368296G>A	ENST00000290438.3	-	8	635	c.595C>T	c.(595-597)Cgg>Tgg	p.R199W		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	199										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						TGTAACCACCGCTGGAGGACC	0.572000													4	234					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													4	97					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13656035	13656035	+	Silent	SNP	A	A	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr10:13656035A>G	ENST00000378572.3	+	8	901	c.741A>G	c.(739-741)aaA>aaG	p.K247K		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	247					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						CTGATATTAAAGAATCAATAA	0.289000													12	62					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	424296	424296	+	Silent	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:424296C>T	ENST00000256509.2	+	18	2760	c.2118C>T	c.(2116-2118)aaC>aaT	p.N706N	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Silent_p.N690N	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	690					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TAGCCGTGAACGAAGTAGGGA	0.468000													5	149					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039088	11039088	+	RNA	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr21:11039088C>A	ENST00000470054.1	-	0	1115									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTTTCTGTTCCTTTTCTCCT	0.413000													32	984					6.00712e-18	7.22376e-18	1	1	0
EFCAB6	64800	broad.mit.edu	37	22	44083357	44083357	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr22:44083357C>T	ENST00000262726.7	-	11	1389	c.1136G>A	c.(1135-1137)aGa>aAa	p.R379K	EFCAB6_ENST00000396231.2_Missense_Mutation_p.R227K|EFCAB6_ENST00000358439.4_Intron	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				ATACCTATTTCTTTTTGTCAG	0.308000													13	48					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79353667	79353667	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr4:79353667G>A	ENST00000264895.6	+	38	5566	c.5126G>A	c.(5125-5127)cGa>cAa	p.R1709Q	FRAS1_ENST00000325942.6_Missense_Mutation_p.R1709Q	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1708					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCAGAAGACCGAGGGCCTCGA	0.532000													6	30					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2464182	2464182	+	Silent	SNP	A	A	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:2464182A>G	ENST00000278772.4	-	6	1912	c.1425T>C	c.(1423-1425)agT>agC	p.S475S	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S475S(2)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						GTGATTTCCGACTAAAGCCTC	0.527000													4	164					0	0	1	0	0
SUDS3	64426	broad.mit.edu	37	12	118828940	118828940	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:118828940G>T	ENST00000543473.1	+	6	682	c.370G>T	c.(370-372)Gtg>Ttg	p.V124L	SUDS3_ENST00000397564.2_Missense_Mutation_p.V125L	NM_022491.2	NP_071936.2	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3 homolog (S. cerevisiae)	124					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding			breast(1)|lung(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACTGAACAAGTGGAACGAAA	0.458000													23	88					4.72057e-08	5.15465e-08	1	1	0
FAM86JP	100125556	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:125647387G>A	ENST00000485843.1	+	0	532					NR_024251.1																						ACCAGAAACTGTTTCCCTATG	0.502000													5	259					0	0	1	0	0
CDC6	990	broad.mit.edu	37	17	38449836	38449836	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:38449836G>A	ENST00000209728.4	+	5	1260	c.789G>A	c.(787-789)atG>atA	p.M263I		NM_001254.3	NP_001245.1	Q99741	CDC6_HUMAN	cell division cycle 6	263					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	21						GGAAGGACATGATGAGGAAAT	0.473000													97	99					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56350977	56350977	+	Silent	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:56350977C>T	ENST00000340482.3	-	8	1691	c.1515G>A	c.(1513-1515)agG>agA	p.R505R	MPO_ENST00000225275.3_Silent_p.R473R			P05164	PERM_HUMAN	myeloperoxidase	473					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GCAGGTACTTCCTCATGGCCG	0.572000													71	312					0	0	1	0	0
AASS	10157	broad.mit.edu	37	7	121718036	121718036	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr7:121718036C>T	ENST00000393376.1	-	22	2613	c.2518G>A	c.(2518-2520)Gac>Aac	p.D840N	AASS_ENST00000473553.1_5'UTR|AASS_ENST00000417368.2_Missense_Mutation_p.D840N			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	840	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCAAAGCTGTCTCTCATCACA	0.353000													38	584					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134019890	134019890	+	Silent	SNP	C	C	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr9:134019890C>G	ENST00000359428.5	+	12	1662	c.1518C>G	c.(1516-1518)tcC>tcG	p.S506S	RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|NUP214_ENST00000451030.1_Silent_p.S506S|RP11-544A12.4_ENST00000588378.1_RNA|NUP214_ENST00000411637.2_Silent_p.S506S|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	506	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CCAGTGGCTCCGACAGCTCCA	0.582000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								52	225					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													5	95					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													5	195					0	0	1	0	0
KCNK6	9424	broad.mit.edu	37	19	38817290	38817290	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:38817290C>T	ENST00000263372.3	+	2	487	c.380C>T	c.(379-381)gCg>gTg	p.A127V		NM_004823.1	NP_004814.1	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	127						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)	17	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	ATCGCCTTTGCGCTCCTGGGC	0.572000													4	222					0	0	1	0	0
FAM86JP	100125556	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	T	C			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:125647396T>C	ENST00000485843.1	+	0	541					NR_024251.1																						TGTTTCCCTATGAAGAGCACT	0.502000													6	265					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878253	5878253	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:5878253A>G	ENST00000537935.1	-	1	711	c.680T>C	c.(679-681)cTg>cCg	p.L227P	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACAGCATACAGGATCCTGAC	0.453000													5	73					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073412	135073412	+	Silent	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr9:135073412G>A	ENST00000393229.3	+	3	1049	c.273G>A	c.(271-273)ccG>ccA	p.P91P	NTNG2_ENST00000393228.4_Silent_p.P91P|NTNG2_ENST00000360670.3_Silent_p.P91P|NTNG2_ENST00000372179.3_Silent_p.P91P	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	91	Laminin N-terminal.				axonogenesis	anchored to plasma membrane		p.P91P(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TGGCCCACCCGCCCAGGCTCA	0.647000													4	108					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156884528	156884528	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:156884528C>T	ENST00000338302.3	+	24	3277	c.3052C>T	c.(3052-3054)Cat>Tat	p.H1018Y	PEAR1_ENST00000292357.7_Missense_Mutation_p.H1018Y			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	1018	Pro-rich.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CATCCCTGGACATTATGACTT	0.622000													32	167					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Intron														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													6	367					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3945846	3945846	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:3945846T>A	ENST00000381638.2	-	39	6307	c.6183A>T	c.(6181-6183)gaA>gaT	p.E2061D		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2061							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GAGATGACACTTCTGAATCTT	0.448000													32	97					0	0	1	0	0
GORASP1	64689	broad.mit.edu	37	3	39142283	39142283	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:39142283C>T	ENST00000319283.3	-	5	1342	c.521G>A	c.(520-522)cGg>cAg	p.R174Q	GORASP1_ENST00000479927.1_Missense_Mutation_p.R79Q|GORASP1_ENST00000422110.2_Intron	NM_031899.2	NP_114105.1	Q9BQQ3	GORS1_HUMAN	golgi reassembly stacking protein 1, 65kDa	174					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(1)|ovary(3)|urinary_tract(1)	14				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		AGTCACCTCCCGGCAGGAGTC	0.587000											OREG0015486	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	341					0	0	1	0	0
TTC31	64427	broad.mit.edu	37	2	74710528	74710528	+	Silent	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr2:74710528C>T	ENST00000410003.1	+	2	129	c.120C>T	c.(118-120)taC>taT	p.Y40Y	TTC31_ENST00000233623.5_Silent_p.Y40Y|TTC31_ENST00000442235.2_5'UTR|TTC31_ENST00000463189.1_3'UTR			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	40							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CAGAGGATTACGGCGAAGAGG	0.577000											OREG0014719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	117					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77618829	77618829	+	Silent	SNP	T	T	C	rs143324770		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:77618829T>C	ENST00000534064.1	-	16	1984	c.1950A>G	c.(1948-1950)caA>caG	p.Q650Q	AAMDC_ENST00000532481.1_Intron|INTS4_ENST00000535943.1_Silent_p.Q25Q	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	650					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CCAATTCAGATTGAAGTTCTC	0.403000													39	160					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17413184	17413184	+	Missense_Mutation	SNP	G	G	A	rs141669259		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:17413184G>A	ENST00000444885.2	-	5	503	c.422C>T	c.(421-423)tCg>tTg	p.S141L	PADI2_ENST00000375481.1_Silent_p.F222F|PADI2_ENST00000375486.4_Silent_p.F222F			Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	0					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity	p.F222F(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	AGCGTTGGCCGAAGAACGGGT	0.592000													5	174					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56356990	56356990	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:56356990G>A	ENST00000340482.3	-	4	618	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	MPO_ENST00000225275.3_Nonsense_Mutation_p.Q148*			P05164	PERM_HUMAN	myeloperoxidase	148					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	ACATTCAGCTGGGCGGGCGTC	0.617000													11	54					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803493	142803493	+	RNA	SNP	T	T	C	rs80149641	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:142803493T>C	ENST00000423385.1	-	0	1472																											TGTACATTTATTATTGATTTA	0.323000													23	184					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55955644	55955644	+	Silent	SNP	T	T	C			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr10:55955644T>C	ENST00000373965.2	-	11	1498	c.1104A>G	c.(1102-1104)gaA>gaG	p.E368E	PCDH15_ENST00000395433.1_Silent_p.E346E|PCDH15_ENST00000373955.1_Silent_p.E368E|PCDH15_ENST00000373957.3_Silent_p.E346E|PCDH15_ENST00000437009.1_Silent_p.E368E|PCDH15_ENST00000395432.2_Silent_p.E331E|PCDH15_ENST00000395440.1_Silent_p.E368E|PCDH15_ENST00000414778.1_Silent_p.E373E|PCDH15_ENST00000320301.6_Silent_p.E368E|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Silent_p.E368E|PCDH15_ENST00000395446.1_Silent_p.E368E|PCDH15_ENST00000395438.1_Silent_p.E368E|PCDH15_ENST00000395430.1_Silent_p.E368E|PCDH15_ENST00000409834.1_5'UTR|PCDH15_ENST00000361849.3_Silent_p.E368E	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	368	Cadherin 3.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CATTGTCTTGTTCAGCCTAAA	0.338000										HNSCC(58;0.16)			7	80					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902301	1902301	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:1902301G>A	ENST00000358771.4	+	3	849	c.697G>A	c.(697-699)Gtc>Atc	p.V233I	SIRPA_ENST00000400068.3_Missense_Mutation_p.V233I|SIRPA_ENST00000356025.3_Missense_Mutation_p.V233I	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	233	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V233I(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGTGGCCCACGTCACCTTGCA	0.617000													5	173					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902292	1902292	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:1902292G>A	ENST00000358771.4	+	3	840	c.688G>A	c.(688-690)Gtg>Atg	p.V230M	SIRPA_ENST00000400068.3_Missense_Mutation_p.V230M|SIRPA_ENST00000356025.3_Missense_Mutation_p.V230M	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	230	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding	p.V230M(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CATCTGCGAGGTGGCCCACGT	0.612000													4	159					0	0	1	0	0
RGPD2	729857	broad.mit.edu	37	2	88082471	88082471	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr2:88082471T>A	ENST00000398146.3	-	20	4294	c.4072A>T	c.(4072-4074)Aga>Tga	p.R1358*	RGPD2_ENST00000327544.6_Nonsense_Mutation_p.R615*|RGPD2_ENST00000420840.2_Nonsense_Mutation_p.R1350*			Q68DN6	RGPD1_HUMAN	RANBP2-like and GRIP domain containing 2	1350	RanBD1 2.				intracellular transport		binding			breast(1)|pancreas(1)	2						TTATCATATCTGTAGAGTTCT	0.353000													137	421					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43006189	43006189	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:43006189C>T	ENST00000535468.1	-	25	4927	c.4841G>A	c.(4840-4842)gGc>gAc	p.G1614D	CUL7_ENST00000265348.3_Missense_Mutation_p.G1530D	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1530					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TTCCTTGCTGCCATCTCGAAT	0.577000													27	120					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51465702	51465702	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr8:51465702C>A	ENST00000522124.1	+	12	1434	c.773C>A	c.(772-774)gCa>gAa	p.A258E	SNTG1_ENST00000518864.1_Missense_Mutation_p.A258E|SNTG1_ENST00000276467.5_Missense_Mutation_p.A258E|SNTG1_ENST00000517473.1_Missense_Mutation_p.A258E	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	258					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding	p.A258V(2)		NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGGCTACAAGCAATAGCAACT	0.428000													9	88					7.48243e-07	8.07762e-07	1	1	0
BCRP7	100133163	broad.mit.edu	37	22	18845962	18845962	+	RNA	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr22:18845962G>A	ENST00000412938.1	+	0	3320																											AGATCTCATCGCGGACACCAC	0.517000													10	67					0	0	1	0	0
ZNF461	92283	broad.mit.edu	37	19	37149318	37149318	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:37149318T>G	ENST00000588268.1	-	3	246	c.19A>C	c.(19-21)Atg>Ctg	p.M7L	ZNF461_ENST00000360357.4_Missense_Mutation_p.M7L	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCTCTGAACATCACCAACTCC	0.363000													13	28					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82321803	82321803	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr9:82321803G>C	ENST00000376520.4	+	11	1753	c.925G>C	c.(925-927)Gaa>Caa	p.E309Q	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000265284.6_Missense_Mutation_p.E284Q|TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376552.2_Missense_Mutation_p.E309Q|TLE4_ENST00000376537.4_Missense_Mutation_p.E309Q			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CAAATCCAAAGAACTTAGCCT	0.433000													7	354					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104157408	104157408	+	Silent	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr10:104157408G>A	ENST00000369966.3	+	8	877	c.627G>A	c.(625-627)ctG>ctA	p.L209L	NFKB2_ENST00000189444.6_Silent_p.L209L|NFKB2_ENST00000428099.1_Silent_p.L209L	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	209	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CCCTGCCCCTGAAGCCAGTCA	0.572000			T	IGH@	B-NHL								7	334					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38044780	38044780	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:38044780G>A	ENST00000283713.6	+	15	2047	c.1781G>A	c.(1780-1782)cGg>cAg	p.R594Q	VILL_ENST00000465644.1_Missense_Mutation_p.R312Q|VILL_ENST00000383759.2_Missense_Mutation_p.R594Q			O15195	VILL_HUMAN	villin-like	594					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTGGGAGGCCGGGCCCCCTAC	0.607000											OREG0015475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	25					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													9	141					0	0	1	0	0
NCAPH	23397	broad.mit.edu	37	2	97024843	97024843	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr2:97024843G>A	ENST00000455200.1	+	10	1531	c.1236G>A	c.(1234-1236)atG>atA	p.M412I	NCAPH_ENST00000427946.1_Missense_Mutation_p.M287I|NCAPH_ENST00000240423.4_Missense_Mutation_p.M423I			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	423					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				TTCTGTCTATGAAACCTGGAG	0.453000													23	123					0	0	1	0	0
NUP37	79023	broad.mit.edu	37	12	102512193	102512193	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:102512193A>G	ENST00000552283.1	-	2	243	c.104T>C	c.(103-105)cTa>cCa	p.L35P	NUP37_ENST00000251074.1_Missense_Mutation_p.L35P|NUP37_ENST00000543021.1_5'UTR			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	35					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						ATATGCAATTAGGTTTCCTGA	0.403000													44	218					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													5	247					0.184627	0.186591	1	1	0
PI4KAP2	375133	broad.mit.edu	37	22	21829507	21829507	+	RNA	SNP	G	G	A	rs140118179	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr22:21829507G>A	ENST00000450651.1	-	0	1831																				endometrium(3)|urinary_tract(1)	4						TACTTCAAGAGCTTGATTGTC	0.542000													7	44					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4415016	4415016	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr16:4415016C>G	ENST00000251166.4	-	11	1031	c.886G>C	c.(886-888)Gcg>Ccg	p.A296P	CORO7_ENST00000539968.1_Missense_Mutation_p.A76P|CORO7_ENST00000423908.2_Missense_Mutation_p.A128P|CORO7-PAM16_ENST00000572467.1_Missense_Mutation_p.A296P|CORO7_ENST00000574025.1_Missense_Mutation_p.A211P|CORO7_ENST00000537233.2_Missense_Mutation_p.A278P	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						GGGCTCAGCGCCGGCTGCTGC	0.642000													3	26					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39284197	39284197	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:39284197T>C	ENST00000373229.5	-	5	696	c.683A>G	c.(682-684)tAt>tGt	p.Y228C	KCNK16_ENST00000437525.2_Missense_Mutation_p.Y228C|KCNK16_ENST00000507712.1_Intron|KCNK16_ENST00000425054.2_Intron|KCNK16_ENST00000373227.4_Intron	NM_032115.3	NP_115491.1	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	228						integral to membrane	potassium channel activity|voltage-gated ion channel activity			large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)	13						CACTGAGATATAATGCTTGCT	0.612000													10	41					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100493868	100493868	+	Silent	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr8:100493868C>A	ENST00000395996.1	+	25	3819	c.3708C>A	c.(3706-3708)gtC>gtA	p.V1236V	VPS13B_ENST00000358544.2_Silent_p.V1236V|VPS13B_ENST00000357162.2_Silent_p.V1236V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1236					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGAATAAGGTCTGGAACAAGA	0.418000													23	335					2.21704e-12	2.47786e-12	1	1	0
SVIL	6840	broad.mit.edu	37	10	29821003	29821003	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr10:29821003C>A	ENST00000375398.2	-	11	2386	c.1937G>T	c.(1936-1938)gGt>gTt	p.G646V	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.G646V			O95425	SVIL_HUMAN	supervillin	646					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TCTACTTTCACCAGGAGAAAA	0.512000													29	156					1.30897e-18	1.59426e-18	1	1	0
IGIP	492311	broad.mit.edu	37	5	139508162	139508162	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr5:139508162G>T	ENST00000333305.3	+	1	2642	c.101G>T	c.(100-102)tGt>tTt	p.C34F		NM_001007189.1	NP_001007190.1	A6NJ69	IGIP_HUMAN	IgA-inducing protein	34						extracellular region											AAATCACCATGTGGAAACCAA	0.428000													23	143					1.85244e-09	2.0463e-09	1	1	0
ARID1A	8289	broad.mit.edu	37	1	27100182	27100184	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:27100182_27100184delGCA	ENST00000324856.7	+	16	4349_4351	c.3978_3980delGCA	c.(3976-3981)ccg>cc	p.PQ1326del	ARID1A_ENST00000457599.2_In_Frame_Del_p.PQ1326del|ARID1A_ENST00000374152.2_In_Frame_Del_p.PQ943del|ARID1A_ENST00000540690.1_5'UTR	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1326					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q1327*(1)|p.Q1334delQ(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCTACCCCCCgcagcagcagcag	0.591			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	232	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2892)aaafs	p.K964fs	SYCP1_ENST00000477590.1_3'UTR|SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.K964fs	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													9	122	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	RNA	INS	-	-	AGTT	rs10656368	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr3:14555758_14555759insAGTT	ENST00000273083.3	-	0	1558							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAGTTTCTCTCAGAGAGTGGCA	0.579													3	3	---	---	---	---					
IGF2R	3482	broad.mit.edu	37	6	160485488	160485488	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr6:160485488delG	ENST00000356956.1	+	28	4090	c.3942delG	c.(3940-3942)acfs	p.T1314fs		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1314					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TGAACTTCACGGGGGGGGACA	0.502													8	397	---	---	---	---					
TRBV7-4	28594	broad.mit.edu	37	7	142176678	142176679	+	RNA	DEL	CA	CA	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr7:142176678_142176679delCA	ENST00000390369.2	-	0	49																											GTAGTCATCGCACACACACACA	0.460													7	135	---	---	---	---					
TSPAN4	7106	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)del	p.L92del	TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													10	315	---	---	---	---					
NUP98	4928	broad.mit.edu	37	11	3720389	3720389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:3720389delT	ENST00000324932.7	-	25	4352	c.3932delA	c.(3931-3933)acfs	p.N1311fs	NUP98_ENST00000359171.4_Frame_Shift_Del_p.N1311fs|NUP98_ENST00000355260.3_Frame_Shift_Del_p.N1311fs	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1328					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CACAGGGCTGTTTTTTTGGGT	0.512			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								8	623	---	---	---	---					
FAM111B	374393	broad.mit.edu	37	11	58892377	58892377	+	Frame_Shift_Del	DEL	A	A	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:58892377delA	ENST00000343597.3	+	4	998	c.807delA	c.(805-807)tcfs	p.S269fs	FAM111B_ENST00000529618.1_Frame_Shift_Del_p.S239fs|FAM111B_ENST00000411426.1_Frame_Shift_Del_p.S239fs	NM_198947.3	NP_945185.1	Q6SJ93	F111B_HUMAN	family with sequence similarity 111, member B	269							catalytic activity	p.A273fs*9(1)|p.K272delK(1)|p.A273fs*26(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(12)|ovary(3)|pancreas(1)|skin(1)	40						TGGACATTTCAAAAAAAAAAG	0.313													9	104	---	---	---	---					
FAU	2197	broad.mit.edu	37	11	64888248	64888250	+	In_Frame_Del	DEL	TCT	TCT	-	rs1065065		TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr11:64888248_64888250delTCT	ENST00000529639.1	-	5	696_698	c.305_307delAGA	c.(304-309)aca>a	p.KT102del	FAU_ENST00000279259.3_In_Frame_Del_p.ED83del|FAU_ENST00000525297.1_In_Frame_Del_p.KT67del|FAU_ENST00000529259.1_3'UTR|FAU_ENST00000527548.1_In_Frame_Del_p.KT102del|FAU_ENST00000531743.1_In_Frame_Del_p.KT102del	NM_001997.4	NP_001988.1	P35544	UBIM_HUMAN	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	0										NS(3)|kidney(1)|large_intestine(2)	6						GCCCGACCTGTCTTCTTCTTCTT	0.542													8	250	---	---	---	---					
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr12:122812690_122812691insT	ENST00000358808.2	-	16	3173_3174	c.3019_3020insA	c.(3019-3021)ccafs	p.P1007fs	CLIP1_ENST00000540338.1_Frame_Shift_Ins_p.P1018fs|CLIP1_ENST00000537178.1_Frame_Shift_Ins_p.P972fs|CLIP1_ENST00000361654.4_Frame_Shift_Ins_p.P896fs|CLIP1_ENST00000302528.7_Frame_Shift_Ins_p.P1007fs|CLIP1_ENST00000545889.1_Frame_Shift_Ins_p.P593fs	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1018					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505													7	323	---	---	---	---					
LOC102723841	102723841	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													4	5	---	---	---	---					
FLCN	201163	broad.mit.edu	37	17	17131423	17131423	+	Frame_Shift_Del	DEL	A	A	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr17:17131423delA	ENST00000285071.4	-	4	483	c.29delT	c.(28-30)tcfs	p.F10fs	RP11-45M22.4_ENST00000427497.3_Frame_Shift_Del_p.F10fs|FLCN_ENST00000389169.5_Frame_Shift_Del_p.F10fs	NM_144997.5	NP_659434.2	Q8NFG4	FLCN_HUMAN	folliculin	10					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|stomach(1)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GAGCTCGCAGAAGTGGCAGAG	0.612									Familial Non-VHL Clear Cell Renal Cancer;Birt-Hogg-Dub syndrome				25	51	---	---	---	---					
CHERP	10523	broad.mit.edu	37	19	16640581	16640583	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:16640581_16640583delTGC	ENST00000546361.2	-	8	1156_1158	c.1005_1007delGCA	c.(1003-1008)caa>ca	p.QQ339del	CTD-3222D19.2_ENST00000409035.1_Intron|CHERP_ENST00000198939.6_In_Frame_Del_p.QQ350del	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	339	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						ctgctgctgttgctgctgctgct	0.670													8	93	---	---	---	---					
TEAD2	8463	broad.mit.edu	37	19	49850472	49850473	+	Frame_Shift_Ins	INS	-	-	G			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:49850472_49850473insG	ENST00000377214.4	-	8	1254_1255	c.892_893insC	c.(892-894)tgcfs	p.C298fs	TEAD2_ENST00000311227.2_Frame_Shift_Ins_p.C295fs|TEAD2_ENST00000593945.1_Frame_Shift_Ins_p.C299fs|TEAD2_ENST00000601519.1_Frame_Shift_Ins_p.C298fs|TEAD2_ENST00000598810.1_Frame_Shift_Ins_p.C299fs|TEAD2_ENST00000539846.1_Frame_Shift_Ins_p.C167fs			Q15562	TEAD2_HUMAN	TEA domain family member 2	295	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.H295fs*12(1)		central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GAAGAAGGCATGGGGGGGGCCA	0.564													9	561	---	---	---	---					
USP29	57663	broad.mit.edu	37	19	57640238	57640239	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr19:57640238_57640239insA	ENST00000254181.4	+	4	649_650	c.195_196insA	c.(193-198)tgaaaafs	p.*K65fs	USP29_ENST00000598197.1_Frame_Shift_Ins_p.*K65fs	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	65					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.R68fs*7(1)		breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTAGACATTGTAAAAAAAGACA	0.327													22	57	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628226	29628226	+	Splice_Site	DEL	G	G	-	rs78710112	by1000genomes	TCGA-97-8175-01A-11D-2284-08	TCGA-97-8175-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e9bb6b-c9e8-4961-bc38-a6225237c3da	1459d76e-a2f2-4413-b44e-03a2e67ea76b	g.chr20:29628226delG	ENST00000278882.3	+	6	608		c.e6-1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTTCACTTAGGGGAAAATGG	0.358													8	363	---	---	---	---					
